CN114767603A - Acne-removing cosmetic composition containing red ginseng extract - Google Patents

Abstract

The invention relates to an acne-removing cosmetic composition containing red ginseng extract. The acne-removing cosmetic composition comprises the following components in parts by mass: 0.1-20 parts of red ginseng extract, 0.1-20 parts of natural plant extract, 0.0001-1 part of ammonium salt-73, 0.1-3 parts of salicylic acid, 0.1-30 parts of poloxamer 407, and the natural plant extract is a mixture composed of Radix Curcumae Rhizoma Guangxi extract and Wenyujin extract in a mass ratio of 1:1.

Description

An acne-removing cosmetic composition containing red ginseng extract

technical field

The invention relates to the field of daily cosmetics, in particular to an acne-removing cosmetic composition containing red ginseng extract.

Background technique

Acne, scientifically known as acne, is the most common chronic inflammatory disease of the hair follicles and sebaceous glands in dermatology. The skin lesions usually occur on the cheeks, forehead and jaw, and can also involve the trunk, such as the front chest, back and scapula, with acne and papules. It is characterized by pustules, nodules, cysts and scars, often accompanied by seborrhea, which occurs in adolescent men and women, and is often called "acne". The pathogenesis of acne is mainly related to androgen levels, increased sebum secretion, abnormal keratinization of cells around the hair follicle, excessive proliferation of P. acnes and inflammatory response. Young men and women have strong androgen secretion due to their physical development, and androgens cause the sebaceous glands to produce more sebum. The sebum mixes with the exfoliated epidermal tissue to form a sediment-like substance that blocks pores and causes acne. At present, the anti-acne products on the market mainly remove the keratinized hair follicle epithelium through salicylic acid and fruit acid, and achieve the effect of removing acne through the anti-inflammatory effect of the anti-acne products. However, the existing anti-acne products are more irritating to the skin.

SUMMARY OF THE INVENTION

In view of the technical problems existing in the prior art, the present invention provides an anti-acne cosmetic composition containing red ginseng extract, which can be coated on the surface of the skin to eliminate obstruction and inflammation of the hair follicles and sebaceous glands. Effect.

The ingredients in the acne-removing cosmetic composition provided by the present invention are mainly salicylic acid, quaternary ammonium salt-73 and various natural plant extracts. Therefore, the acne-removing cosmetic composition provided by the present invention can stimulate the skin. Less sexual, and more gentle to use.

In one aspect, the present invention provides an acne-removing cosmetic composition containing red ginseng extract, the acne-removing cosmetic composition comprising the following components in parts by mass: 0.1-20 parts of red ginseng extract, 0.1-20 parts of natural plant extract 20 parts, quaternary ammonium salt-730.0001-1 part, salicylic acid 0.1-3 parts, Poloxamer 407 0.1-30 parts.

The natural plant extract described in the present invention is a mixture of Curcuma radix radix extract and Curcuma radix extract in a mass ratio of 1:1.

In one embodiment, in the acne-removing cosmetic composition, the mass ratio of red ginseng extract, natural plant extract, quaternary ammonium salt-73, poloxamer 407, and salicylic acid is (0.1-20 ): (0.1-20): (0.0001-0.1): (1-10): 1, when the mass parts of red ginseng extract, natural plant extract, quaternary ammonium salt-73, poloxamer 407, salicylic acid When the number ratio is within the above range, the acne-removing cosmetic composition has the most significant acne-removing effect. Preferably, the ratio of red ginseng extract, natural plant extract, quaternary ammonium salt-73, poloxamer 407, and salicylic acid is (0.2-10): (0.1-20): (0.0005-0.01 ):(1-8):1.

The acne-removing cosmetic composition further includes the following components in parts by mass: 1-30 parts of polyols, 1-10 parts of thickeners, 0.2-3 parts of preservatives, and 0.1-3 parts of pH regulators.

The polyol is selected from any one or a combination of at least two of glycerol, butanediol, propylene glycol, 1,2-pentanediol, dipropylene glycol, methylpropanediol, and 1,3-propanediol.

The preservative is selected from phenoxyethanol, p-hydroxyacetophenone, 1,2-hexanediol, caprylyl glycol, capryloylhydroxamic acid, chlorphenesin, o-cymene-5-ol, hydroxybenzene Any one or a combination of at least two of methyl ester, benzoic acid and salts thereof.

The thickening agent is selected from carbomer, xanthan gum, polyacrylamide, ammonium acryloyldimethyltaurate/VP copolymer, hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer, Any one or a combination of at least two of polyacrylate cross-linked polymer-6, hydroxyethyl cellulose, sodium alginate, cellulose gum, and sodium polyacryloyldimethyltaurate.

The pH adjusting agent is selected from any one or a combination of at least two of potassium hydroxide, sodium hydroxide, aminomethyl propanol, triethanolamine, and arginine.

In one embodiment, the anti-acne cosmetic composition is a stock solution, essence or gel.

Compared with the prior art, the technical solution provided by the present invention has at least the following beneficial effects:

1. The present invention provides an acne-removing cosmetic composition containing red ginseng extract, which is synergistically synergized by the rational compounding of red ginseng extract and other components, and achieves good acne-removing, The anti-inflammatory and bacteriostatic effects can significantly reduce the irritation to the skin, and the acne-removing cosmetic composition can prevent acne, eliminate acne, and reduce inflammation caused by acne.

2. The acne-removing cosmetic composition provided by the present invention has low irritation, and the salicylic acid is slowly released through the slow-release material poloxamer 407, thereby reducing the irritation brought by the salicylic acid to the skin.

3. The acne-removing cosmetic composition provided by the present invention starts from various causes of acne, and solves the skin problems caused by acne. Specifically:

(1) By exfoliating the keratin to let the acne break out. The anti-acne mechanism of salicylic acid is to release the keratin plugs in the hair follicles, and it has mild anti-inflammatory and antibacterial effects at the same time;

(2) Kill or inhibit fat-affinity microorganisms through sterilization, and at the same time whiten and lighten newly generated acne marks. Quaternary ammonium salt-73, also known as Piao Ning, has the effect of inhibiting Propionibacterium acnes and can quickly eliminate acne. At the same time, it can inhibit the formation of melanin, which can lighten acne marks while removing acne;

(3) By regulating sebum secretion to reduce skin oil, thereby reducing the blockage of sebum in hair follicles and preventing the formation of acne. Natural plant extracts can effectively reduce sebum;

(4) Reduce skin inflammation caused by acne through anti-inflammatory and anti-allergy. The active ingredients in red ginseng extract, such as ginsenosides, acidic polysaccharides, etc., can effectively prevent acne, improve the degree of keratinization of hair follicles, and slow down skin inflammation;

4. The acne-removing cosmetic composition provided by the present invention kills or inhibits the growth of fat-affinity microorganisms through quaternary ammonium salt-73, and at the same time whitens and lightens acne marks; regulates sebum secretion through natural plant extracts to reduce oily skin and reduce The blockage of sebum at the hair follicles can prevent the formation of acne; the red ginseng extract is used to reduce inflammation and anti-allergy to reduce skin inflammation caused by acne; and the ingredients are safe, mild and low in irritation, with a good use experience and a long shelf life.

Detailed ways

It should be understood that the specific embodiments described herein are only used to explain the present invention, but not to limit the present invention.

The raw materials and equipment used in the acne-removing cosmetic composition provided by the present invention, unless otherwise specified, are commonly used raw materials and equipment in the field, and all come from commercially available products.

The composition ratios of the acne-removing cosmetic compositions provided in Examples 1-6 are shown in Table 1, the compositional ratios of the acne-removing cosmetic compositions provided in Examples 7-10 are shown in Table 2, and the composition ratios of the acne-removing cosmetic compositions provided in Comparative Examples 1-5 are shown in Table 2. The composition ratio of the acne cosmetic composition is shown in Table 3, and the composition ratio of the acne treatment cosmetic composition provided by Comparative Examples 6-7 is shown in Table 4.

The preparation method of the acne-removing cosmetic composition provided by embodiment 1-10 comprises the following steps:

Step 1, premix quaternary ammonium salt-73 and butanediol, then heat to 60-75°C until the powder is completely dissolved, for use, and denoted as phase C;

Step 2, pre-mixing p-hydroxyacetophenone and 1,2-hexanediol, then heating to 60-75°C until the powder is completely dissolved, for use, denoted as E phase, E phase is a preservative;

Step 3: Premix polyacrylate cross-linked polymer-6 (thickener) with glycerin and water, then heat to 80-85°C, dissolve until particle-free, denoted as phase A;

Step 4: Add phase B into phase A, and stir at a constant temperature of 80-85°C until the mixture is uniform and free of particles;

Step 5: Add phase C, phase D and phase E to phase A in turn, then add phase F (phase F is a pH regulator) to adjust pH to 4.0-6.0, stir at a constant temperature of 80-85°C until the mixture is uniform and No particulate matter, and then discharged after cooling to room temperature.

Table 1

Table 2

The preparation methods of the acne-removing cosmetic compositions provided in Comparative Examples 1-5 are the same as the preparation methods of the acne-removing cosmetic compositions provided in Example 4.

The only difference between the acne-removing cosmetic composition provided in Comparative Example 1 and the acne-removing cosmetic composition provided in Example 4 is that it does not contain salicylic acid, poloxamer 407, quaternary ammonium salt-73, red ginseng extract, natural plants Extract.

The only difference between the acne-removing cosmetic composition provided in Comparative Example 2 and the acne-removing cosmetic composition provided in Example 4 is that it does not contain quaternary ammonium salt-73, red ginseng extract, or natural plant extract.

The only difference between the acne-removing cosmetic composition provided in Comparative Example 3 and the acne-removing cosmetic composition provided in Example 4 is that it does not contain salicylic acid, poloxamer 407, red ginseng extract, or natural plant extract.

The only difference between the acne-removing cosmetic composition provided in Comparative Example 4 and the acne-removing cosmetic composition provided in Example 4 is that it does not contain salicylic acid, poloxamer 407, quaternary ammonium salt-73, and natural plant extracts.

The only difference between the acne-removing cosmetic composition provided in Comparative Example 5 and the acne-removing cosmetic composition provided in Example 4 is that it does not contain salicylic acid, poloxamer 407, quaternary ammonium salt-73, and red ginseng extract.

The acne-removing cosmetic composition provided in Comparative Example 6 is a common acne-removing product, and salicylic acid, polysorbate-20, and bisabolol are selected as the acne-removing composition.

The acne-removing cosmetic composition provided in Comparative Example 7 is a common acne-removing product, and salicylic acid, polysorbate-20, purslane extract, and tea extract are selected as the acne-removing composition.

table 3

Table 4

Test comparison

1. Red zone feature count

Test samples: The acne-removing cosmetic composition provided in Example 4 and the acne-removing cosmetic composition provided in Comparative Example 6 were used as test samples

HC1023Q多功能3D皮肤成像分析仪Test instrument: Antera

HC1023Q Multifunctional 3D Skin Imaging Analyzer

Test subjects: 30 subjects in each group, aged between 18 and 50 years old, healthy male or female; face with grade I and grade II acne (it is recommended to select grade II acne as much as possible), and the acne area can meet the blank control requirements ;

testing method:

1. Use the test sample on the acne area (dip the test sample lightly on the corresponding acne), twice a day, morning and evening after cleansing the face, use it for 14 days;

2. Use Antera 3D to measure before use, 3d, 7d and 14d after use.

3. Using Antera 3D skin imaging to analyze the average value of the red zone characteristics of the acne area, redness subsides means facial redness or reduced inflammation.

The changes in the red zone feature counts of subjects at different time points after use are shown in Table 5. The difference analysis of the red zone feature counts of subjects after use is shown in Table 6.

It can be seen from the test results that the acne-removing cosmetic composition provided in Example 4 has a better acne-removing effect than the acne-removing cosmetic composition provided in Comparative Example 6.

table 5

Table 6

2. Antibacterial test

Test samples: The acne-removing cosmetic compositions provided in Examples 1-10 and the acne-removing cosmetic compositions provided in Comparative Examples 6-7 were used as test samples

Test strain: Select the skin resident bacteria that causes acne -- Propionibacterium acnes ATCC11827 (Guangdong Provincial Microbial Culture Preservation Center)

Test method: refer to the K-B agar method and Oxford cup method recommended by the American Committee for Clinical Standards (NCCLS). Propionibacterium acnes, which is a skin resident bacterium that causes acne, was propagated and cultured in a fortified Clostridium medium and used. On the fortified Clostridium medium plate medium, evenly inoculate the prepared P. acnes solution with a sterile cotton swab. The transparent area, which is a range in which acne bacteria cannot grow, was measured, and the effects of the respective samples were compared.

The bacteriostatic effect is shown in Table 7. The anti-acne cosmetic compositions provided in Examples 1-10 have excellent antibacterial effects.

Table 7

serial number sample code Inhibition zone size/mm Result judgment (whether there is antibacterial effect) 1 Comparative Example 6 0 No bacteriostatic effect 2 Comparative Example 7 0 No bacteriostatic effect 3 Example 1 16.21 Has obvious antibacterial effect 4 Example 2 15.85 Has obvious antibacterial effect 5 Example 3 16.37 Has obvious antibacterial effect 6 Example 4 19.45 Has obvious antibacterial effect 7 Example 5 19.89 Has obvious antibacterial effect 8 Example 6 20.04 Has obvious antibacterial effect 9 Example 7 20.28 Has obvious antibacterial effect 10 Example 8 32.17 Has obvious antibacterial effect 11 Example 9 31.68 Has obvious antibacterial effect 12 Example 10 33.42 Has obvious antibacterial effect

3. Subjects' self-evaluation after using the product

Test sample: select the acne-removing cosmetic composition provided in Example 4 as the test sample

Test method: During the use of the test samples, subjects made subjective evaluations according to the individual's usage after the 3rd, 7th, and 14th days of the test cycle. The specific evaluation results are shown in Table 8. According to the data in Table 8, it can be seen that after using the test sample for 14 days, the subjects who felt most of the acne disappeared increased from 1 to 20 subjects, that is, from 3.33% to 66.7%, as high as 96.7% of the subjects Symptoms were relieved, partially disappeared, mostly disappeared, and completely disappeared, and there were no other side effects during use.

Table 8

The inventor has further studied and found that the quaternary ammonium salt-73 in the acne-removing cosmetic composition provided by the present invention can be replaced by o-cymene-5-ol, but o-cymene-5-ol is used to replace the quaternary ammonium salt-73 Afterwards, it was found that the anti-acne effect of the anti-acne cosmetic composition showed a weakening trend.

The inventors further researched and found that the poloxamer 407 in the acne-removing cosmetic composition provided by the present invention can use polysorbate-80, polysorbate-20, polysorbate-60, PEG-40 hydrogenated castor At least one of sesame oil and PEG-60 hydrogenated castor oil is replaced, but after the replacement, it is found that the skin irritation of the acne-removing cosmetic composition tends to increase.

There are also various other implementable technical solutions in this application, which are not listed here one by one, and the technical solutions claimed in the claims of this application are all implementable.

Contents not described in detail in the specification of the present application belong to the common knowledge of those skilled in the art.

As mentioned in the entire specification and claims, "comprising" is an open-ended term, so it should be interpreted as "including but not limited to". "Approximately" means that within an acceptable error range, those skilled in the art can solve the technical problem within a certain error range, and basically achieve the technical effect.

It should also be noted that the terms "comprising", "comprising" or any other variation thereof are intended to encompass non-exclusive inclusion, such that a commodity or system comprising a list of elements includes not only those elements, but also includes not explicitly listed other elements, or elements inherent to the commodity or system. Without further limitation, an element defined by the phrase "comprising a..." does not preclude the presence of additional identical elements in the article or system that includes the element.

The above description shows and describes several preferred embodiments of the present application, but as mentioned above, it should be understood that the present application is not limited to the form disclosed herein, and should not be regarded as excluding other embodiments, but can be used in various and other combinations, modifications and environments, and can be modified within the scope of the inventive concepts described herein, from the above teachings or from skill or knowledge in the relevant art. However, modifications and changes made by those skilled in the art do not depart from the spirit and scope of the present application, and should all fall within the protection scope of the appended claims of the present application.

Claims (8)

1. The acne-removing cosmetic composition containing the red ginseng extract is characterized by comprising the following components in parts by mass: 0.1-20 parts of red ginseng extract, 0.1-20 parts of natural plant extract, 0.1-730.0001-1 parts of quaternary ammonium salt, 0.1-3 parts of salicylic acid and 4070.1-30 parts of poloxamer, wherein the natural plant extract is prepared from curcuma kwangsiensis extract and curcuma wenyujin extract according to the mass ratio of 1: 1, in a mixture of the components.

2. The anti-acne cosmetic composition according to claim 1, wherein the mass part ratio of the red ginseng extract, the natural plant extract, the quaternary ammonium salt-73, the poloxamer 407 and the salicylic acid is (0.1-20): (0.1-20): (0.0001-0.1): (1-10): 1.

3. the anti-acne cosmetic composition according to claim 2, wherein the mass part ratio of the red ginseng extract, the natural plant extract, the quaternary ammonium salt-73, the poloxamer 407 and the salicylic acid is (0.2-10): (0.1-20): (0.0005-0.01): (1-8): 1.

4. the anti-acne cosmetic composition of claim 1, further comprising the following components in parts by weight: 1-30 parts of polyhydric alcohol, 1-10 parts of thickening agent, 0.2-3 parts of preservative and 0.1-3 parts of pH regulator.

5. The anti-acne cosmetic composition of claim 4, wherein the polyhydric alcohol is any one or a combination of at least two of glycerol, butylene glycol, propylene glycol, 1, 2-pentanediol, dipropylene glycol, methyl propanediol, 1, 3-propanediol.

6. The anti-acne cosmetic composition of claim 4, wherein the preservative is selected from any one or a combination of at least two of phenoxyethanol, p-hydroxyacetophenone, 1, 2-hexanediol, caprylyl glycol, caprylyl hydroxamic acid, chlorphenesin, o-cymen-5-ol, methylparaben, benzoic acid, and salts thereof.

7. The anti-acne cosmetic composition of claim 4 wherein the thickener is selected from the group consisting of carbomers, xanthan gum, polyacrylamide, ammonium acryloyldimethyltaurate/VP copolymer, hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer, polyacrylate crosspolymer-6, hydroxyethylcellulose, sodium alginate, cellulose gum, sodium polyacrylyldimethyltaurate, and combinations of at least two thereof.

8. The anti-acne cosmetic composition of claim 4, wherein: the pH regulator is selected from any one of potassium hydroxide, sodium hydroxide, aminomethyl propanol, triethanolamine and arginine or the combination of at least two of the potassium hydroxide, the sodium hydroxide, the aminomethyl propanol, the triethanolamine and the arginine.