CN114712618A - A dual-chamber syringe and a charging method - Google Patents

Abstract

The invention belongs to the field of medicines and medical instruments, and relates to a double-chamber syringe and a charging method. Specifically, include injection head (21), syringe (10), plug (16) and push rod (32), wherein: the injection cylinder (10) comprises a front chamber cylinder (11) and a rear chamber cylinder (13), wherein the front chamber cylinder (11) is detachable. The invention reduces the preparation process flow of the solid powder after the freeze-drying of the medicine, realizes that the solid medicine and the injection are pre-filled in the same injector, can realize the one-time completion of the medicine dispensing and the injection, has simple and convenient operation, avoids the pollution of the medicine packaging and the medicine dispensing process, and obviously reduces the preparation and use cost.

Description

A dual-chamber syringe and a charging method

technical field

The invention belongs to the field of medicine and medical equipment, and relates to a double-chamber syringe and a charging method. Specifically, the present invention relates to a dual-chamber syringe prefilled with lyophilized medicine. The present invention also relates to a charging method for the dual-chamber syringe.

Background technique

For powder injection drugs that are chemically unstable and heat-sensitive, vials are usually used as containers to hold the drugs, and they can be sealed by crimping after lyophilization, which can be stored for a long time. When in use, the hospital nurses usually dissolve the medicine with the injection in proportion to complete the configuration of the injection medicine. This method requires professional and skilled operators (such as nurses) and a clean environment, and the configuration process takes a certain amount of time, which is not suitable for self-use by patients outside the hospital or in emergency situations.

At present, some solid-liquid dual-chamber syringes on the market can solve the above problems, and can quickly mix the injection liquid and the drug powder during use, so that the dispensing and injection can be completed at one time. Although the operation process of this type of syringe is simple, the process of drug production and preparation and the process of sub-packaging into the syringe is relatively complicated, the environmental requirements are relatively high, and the quality control is relatively difficult. The commonly used method of drug distribution in this type of syringe is to pre-fill the injection solution, then sterilize it at high temperature, and finally manually fill the drug powder. Due to high temperature sterilization in this method, some water will remain in the seals such as rubber stoppers, which will easily penetrate into the drug powder and affect the stability of the drug. Moreover, the operation of manual accurate quantitative filling is relatively complicated, and the operability of the syringe for drug dispensing is poor. In addition, the preparation process of drug powder is relatively complicated. On the basis of drug freeze-drying, drugs need to be pulverized and collected. On the one hand, a strict clean environment is required to ensure the sterility of the drug preparation process; It needs to be exposed to the air for a long time, and the environment needs to be dried to avoid exposure of the drug to the humid air, which will affect the stability of the drug. Therefore, although the existing solid-liquid dual-chamber syringe is simple to operate, the process of drug filling is complicated and the operability is poor.

Currently, new dual-chamber syringes need to be developed.

SUMMARY OF THE INVENTION

Through in-depth research and creative work, the inventor has produced a pre-filled drug dual-chamber syringe with a front and rear chamber barrel structure, wherein the front chamber barrel is a container for drugs, freeze-dried together with liquid drugs, and directly after the freeze-drying is completed. Assembled into a syringe; the rear chamber barrel is loaded with a dose of vehicle for injection. When not in use, the front chamber barrel and the rear chamber barrel are separated from each other, and the medicine in the front chamber remains dry and solid; when in use, the front chamber barrel and the rear chamber barrel are connected, and the injection enters the front chamber barrel to mix with the solid drug. Thereby the following invention is provided:

One aspect of the present invention relates to a syringe, comprising an injection head (21), a syringe barrel (10), a push plug (16) and a push rod (32), wherein:

The injection barrel (10) includes a front chamber barrel (11) and a rear chamber barrel (13), wherein the front chamber barrel (11) is detachable;

Preferably, the antechamber (11) can be used to contain liquids and for lyophilization.

In some embodiments of the present invention, in the syringe, there is a rubber stopper (14) in the front chamber barrel (11).

In some embodiments of the present invention, the syringe, wherein the rear chamber barrel (13) has a blocking plug (15) close to the proximal end (13a) of the rear chamber barrel (13) for use in the front chamber barrel (11). ) and the partition of the rear chamber barrel (13); and a push plug (16) located at the distal end (13b) of the rear chamber barrel (13).

In some embodiments of the present invention, in the syringe, the vertical distance from the rubber stopper (14) to the proximal end (11a) of the anterior chamber barrel (11) is represented as L, where L is 1-3 of the thickness of the blocking plug 15 times;

Preferably, L is 1.2-1.8 times the thickness of the partition plug 15 (eg 1.2 times, 1.3 times, 1.4 times, 1.5 times, 1.6 times, 1.7 times or 1.8 times);

More preferably, L is 1.4-1.6 times the thickness of the blocking plug 15 .

In some embodiments of the present invention, in the syringe, the front chamber barrel (11) and the rear chamber barrel (13) have the same diameter and are both independent tubes.

In some embodiments of the present invention, in the syringe, the distal end (11b) of the front chamber barrel (11) and the proximal end (13a) of the rear chamber barrel (13) are connected through a connecting barrel (12), and the connection is The diameter of the barrel (12) is the same as that of the front chamber barrel (11) and the rear chamber barrel (13).

In some embodiments of the present invention, in the syringe, the length of the middle part of the connecting barrel (12) is represented as H, and H is 1.2-1.8 times (eg 1.2 times, 1.3 times, 1.4 times the thickness of the blocking plug 15) , 1.5 times, 1.6 times, 1.7 times or 1.8 times), preferably 1.4-1.6 times, more preferably 1.5 times;

Preferably, H is less than the sum of the thicknesses of the blocking plug 15 and the push plug 16 .

In some embodiments of the present invention, in the syringe, one or more communication grooves (12a) are provided in the middle part of the connecting cylinder (12); the communication grooves (12a) are used to communicate with the front chamber cylinder (11) and the the rear chamber barrel (13), when the blocking plug (15) slides to the middle part of the connecting barrel (12), the front chamber barrel (11) and the rear chamber barrel (13) are communicated;

Preferably, the number of communication grooves (12a) is 1-6, more preferably 2, 3 or 4.

In some embodiments of the present invention, in the syringe, one or more damping ribs (12b) are provided in the middle part of the connecting cylinder (12);

Preferably, the number of damping ribs (12b) is 1-6, more preferably 2, 3 or 4.

In some embodiments of the present invention, in the syringe, the vertical distance from the blocking plug (15) to the proximal end (13a) of the rear chamber barrel (13) is represented as M, where M is 0.5 of the thickness of the blocking plug (15). to 1 times.

In some embodiments of the present invention, the syringe, wherein the proximal end (10a) of the syringe barrel (10) is connected with the injection head (21).

In some embodiments of the present invention, the syringe, wherein,

The inner diameter D of the inner cavity of the injection head (21) is 5% to 10% larger than the outer diameter of the rubber stopper (14); and

The inner cavity height N of the injection head (21) is greater than the thickness of the rubber stopper (14), preferably N is 1.2-1.4 times the thickness of the rubber stopper (14).

In some embodiments of the present invention, the syringe, wherein,

There are grooves (21a) around and at the bottom of the inner cavity of the injection head (21), and the grooves (21a) communicate with the needle nozzle (21c),

Preferably, there are 1-6 grooves (21a), preferably 2, 3 or 4;

In some embodiments of the present invention, in the syringe, there are at least two ribs (21b) around the inner cavity of the injection head (21), the ribs are circumferentially arranged at equal intervals, and the inner circle surrounded by all the ribs The diameter is equal to the diameter of the rubber stopper (14);

Preferably, the number of ribs is 3-12, preferably 3-6.

In some embodiments of the present invention, in the syringe, the injection head (21) is connected with the injection needle seat (22); the injection needle seat (22) fixes the injection needle (23);

Preferably, the injection head (21) and the injection needle seat (22) are connected in the form of threads;

Preferably, the injection needle seat (22) is also connected to the injection needle cover (24).

In some embodiments of the present invention, in the syringe, wherein the push plug (16) in the rear chamber barrel (13) is connected to the push rod (32);

Preferably, the push rod (32) and the push plug (16) are connected in the form of threads;

Preferably, the distal end (10b) of the syringe (10) is connected with a finger handle (31);

Preferably, the finger handle (31 and the push rod (32) constitute the structure of the syringe for one-handed injection operation;

Preferably, there is a water suction ring (33) on the side of the push rod (32) close to the push plug (16), and the push rod (32) is connected to the water suction ring (33) and the push plug (16) through the finger handle (31). ;

Preferably, the diameter of the middle opening of the finger handle (31) is smaller than the diameters of the water suction ring (33) and the push plug (16).

In some embodiments of the present invention, in the syringe, the container (101) formed by the front chamber barrel (11) and the rubber stopper (14) can be used to hold liquid medicines and freeze-dried;

Preferably, the solid drug obtained after lyophilization can be directly used for packaging of the syringe.

In some embodiments of the present invention, the syringe, wherein the back chamber barrel (13) and the container (102) formed by the blocking plug (15) and the push plug (16) can be used for pre-filling the injection solution.

Another aspect of the present invention relates to a method for charging a syringe according to any one of the present invention, comprising the steps of:

① The sterilized front chamber barrel (11) or the container (101) formed by the sterilized front chamber barrel (11) and the rubber stopper (14) is filled with solid medicine or liquid medicine; Freeze-dried in a clean environment to obtain solid drug after freeze-drying;

② Assemble the sterilized rear chamber cylinder (13), push plug (16), optional finger handle (31), push rod (32) and optional water suction ring (33) to form a container (102) ;

③ In a sterile and clean environment, sub-fill the injection solution into the container (102), and then install the partition plug (15) after pipetting.

In some embodiments of the invention, the syringe is a medical syringe.

In some embodiments of the present invention, the drug in the front chamber is a solid drug or a liquid drug, preferably a liquid drug suitable for lyophilization or a solid drug obtained after lyophilization, such as a lyophilized preparation, preferably a lyophilized powder for injection.

In some embodiments of the invention, the anterior chamber cartridge is an injection fluid.

In the present invention, unless otherwise specified, the term "proximal end" refers to the end close to the injection head or the injection needle; the term "distal end" refers to the end away from the injection head or the injection needle.

In the present invention, unless otherwise specified, the term "diameter" refers to the diameter that can pass through, and is equal to the inner diameter in most cases. For 11 and 13, it is the inner diameter of the cylinder; 12 has grooves and ribs inside, and its diameter is equal to the diameter of the inner main circle (or the inner diameter). The size of the diameter is not particularly limited, and can be designed according to needs. In some embodiments of the present invention, each of the diameters is independently 3-30mm, preferably 5-20mm, more preferably 5-15mm, particularly preferably 8-12mm, such as 8mm, 9mm, 10mm, 11mm or 12mm.

In some embodiments of the present invention, in order to facilitate lyophilization and contain a certain amount of medicine, the length of the antechamber barrel is 1-10 cm, preferably 2-8 cm, more preferably 3-6 cm.

In some embodiments of the present invention, the approximate length of the rear chamber barrel is 1-6 cm, preferably 2-5 cm, more preferably 3-4 cm in order to accommodate the injection vehicle for dissolving the drug.

In the present invention, unless otherwise specified, the term "injection" may contain an active ingredient, or may be an injection vehicle without an active ingredient; preferably an injection vehicle without an active ingredient.

The syringe used for prefilled medicament consists of a front chamber barrel, a connecting barrel and a back chamber barrel, wherein the front chamber barrel is used to load the lyophilized solid drug, and the back chamber barrel is loaded with the injection vehicle for dissolving or dispersing the solid drug. ; The front chamber barrel and the rear chamber barrel are connected by a connecting barrel, and there are multiple rubber plugs in the middle for the partition of the front chamber barrel and the rear chamber barrel. These can slide in the entire injection barrel and ensure the airtightness of the front and rear chambers; the front chamber The other end of the barrel is connected to the injection needle kit, and the other end of the rear chamber barrel is connected to the syringe push rod and the finger handle; the connecting barrel has multiple side channels, when the push rod pushes the injection forward and the middle rubber plug reaches the connecting sleeve, the front chamber barrel and the The rear chamber barrel is connected, and the injection liquid enters the front chamber barrel from the rear chamber barrel to be mixed with the solid drug, thereby completing the drug preparation before injection. As a container for liquid medicine, the anterior chamber cylinder can be directly put into the freeze-drying machine, and after the freeze-drying is completed, it can be directly assembled with other components to form a syringe. The invention reduces the preparation process of the solid powder after the freeze-drying of the medicine, realizes that the solid medicine and the injection liquid are pre-packed in the same syringe, and can realize the one-time completion of medicine dispensing and injection. It is easy to operate, avoids the pollution of medicine packaging and dispensing process, and has low preparation and use costs.

Beneficial Effects of Invention

The dual-chamber syringe of the present invention can mix the injection liquid with the freeze-dried drug during use, so that the dispensing and injection can be completed at one time, and at the same time, the difficulty in drug sub-packaging of the solid-liquid dual-chamber syringe is solved.

Description of drawings

In the following accompanying drawings 1 to 7E, unless otherwise specified, the meanings of the reference numerals are as follows:

1, medicine; 1a, liquid medicine; 1b, solid medicine;

2. Injection;

10, the syringe; 10a, the proximal end of the syringe; 10b, the distal end of the syringe;

11, anterior chamber barrel; 11a, proximal end of anterior chamber barrel (same as 10a); 11b, distal end of anterior chamber barrel;

12, connecting cylinder; 12a, communicating groove; 12b, damping rib;

13, the rear chamber barrel; 13a, the proximal end of the rear chamber barrel; 13b, the distal end of the rear chamber barrel (same as 10b);

14, rubber plug; 15, partition plug; 16, push plug;

21, injection head; 21a, groove; 21b, rib; 21c, needle mouth;

22, injection needle seat; 23, injection needle; 24, injection needle cover;

31, finger handle; 32, push rod; 33, suction ring;

101, the space used to hold the medicine in the front chamber barrel; 102, the space used to hold the injection in the rear chamber barrel;

L, the distance between the rubber stopper 14 and the proximal end 11a of the front chamber barrel 11;

M, the length of the blocking plug 15 from the port of the rear chamber barrel 13;

N, the height of the inner cavity of the injection head 21;

D: The inner diameter of the inner cavity of the injection head 21 .

Figure 1: A schematic longitudinal cross-sectional view of a dual-chamber syringe in one embodiment of the present invention.

Figure 2A: Schematic diagram of the longitudinal section of the antechamber barrel before the drug is lyophilized (containing the liquid drug). Front chamber tube 11 and rear chamber tube 13 .

Figure 2B: Schematic diagram of the longitudinal section of the front chamber barrel after the drug is lyophilized (containing solid drug).

Figure 3A: A schematic longitudinal cross-sectional view of the connecting cylinder.

Figure 3B: Schematic cross-sectional view of the connecting barrel.

Figure 4: Schematic longitudinal section of the back chamber barrel loaded with injection fluid.

Figure 5A: Schematic longitudinal section of the injection head.

Figure 5B: A partial enlarged view of Figure 5A.

Figure 5C: Schematic cross-sectional view of the injection head.

Figure 6: Schematic longitudinal section of the connecting cylinder connecting the front and rear chambers.

Fig. 7A: The state of the syringe before use (schematic longitudinal section).

FIG. 7B : a state in which the front chamber barrel 11 and the rear chamber barrel 13 of the syringe communicate with each other (a schematic longitudinal cross-sectional view).

FIG. 7C : a state in which the injection solution 2 of the rear chamber barrel 13 has all entered the front chamber barrel 11 (a schematic diagram of a longitudinal section).

Fig. 7D: A state in which the syringe is being evacuated (schematic longitudinal cross-section).

Figure 7E: Syringe ready for injection (schematic longitudinal section).

Detailed ways

The embodiments of the present invention will be described in detail below with reference to the examples, but those skilled in the art will understand that the following specific embodiments are only used to illustrate the present invention, and should not be regarded as limiting the scope of the present invention.

(1) About the structure of the syringe

As shown in FIG. 1, the syringe 10 for prefilled medicine is composed of a front chamber barrel 11, a connecting barrel 12 and a rear chamber barrel 13; the distal end 11b of the front chamber barrel 11 and the proximal end 13a of the rear chamber barrel 13 pass through the connecting barrel 12 is connected; there is a rubber plug 14 in the front chamber barrel 11, and the distance from the proximal end 11a of the front chamber barrel 11 is L; there are two rubber plugs in the rear chamber barrel 13, one is a blocking plug close to the proximal end 13a of the rear chamber barrel 13 15, for the partition of the front chamber barrel 11 and the rear chamber barrel 13; the other is the push plug 16 located at the distal end 13b of the rear chamber barrel 13; the front chamber barrel 11, the connecting barrel 12 and the rear chamber barrel 13 have the same diameter, The rubber plug 14 , the blocking plug 15 and the push plug 16 can all slide in the front chamber barrel 11 , the connecting barrel 12 and the rear chamber barrel 13 , and can maintain air tightness.

The proximal end 10a of the syringe barrel 10 (also the proximal end 11a of the front chamber barrel 11) is connected with the injection head 21; the injection head 21 is connected with the injection needle seat 22, and the two are connected in the form of threads; the injection needle seat 22 fixes the injection needle 23 , and also connected to the injection needle cover 24 for protecting the injection needle 23 .

The distal end 10b of the syringe barrel 10 (also the distal end 13b of the rear chamber barrel 13) is connected to the finger handle 31; the push plug 16 in the rear chamber barrel 13 is connected to the push rod 32, and the finger handle 31 and the push rod 32 constitute a one-handed injection operation of the syringe The push rod 32 is connected with the push plug 16 through threads, etc.; there is a water suction ring 33 on the side of the push rod 32 close to the push plug 16.

A more detailed structural scheme is described as follows:

As shown in Figures 2A and 2B, the container 101 formed by the front chamber barrel 11 and the rubber stopper 14 can be used to hold the liquid medicine 1a and freeze-dried; the freeze-dried solid medicine 1b can be directly used for the packaging of the syringe; The distance from the proximal end 11a of the chamber barrel 11 is L; preferably, L is 1-3 times the thickness of the blocking plug 15, more preferably, L is 1.2-1.8 times the thickness of the blocking plug 15, such as 1.2, 1.3, 1.4, 1.5, 1.6, 1.7 or 1.8 times; particularly preferably 1.5 times.

Without being bound by theoretical limitations, when the partition plug 15 moves forward, the rubber plug 14 also moves forward. It is necessary to ensure that when the partition plug 15 just fully enters the connecting cylinder 12, all or part of the rubber plug 14 is still in the front chamber cylinder 11 to avoid. During the mixing process of the front and rear chambers, the front chamber barrel 11 communicates with the injection head 21 . If L is too short, the rubber stopper 14 will enter the injection head 21, and the front chamber barrel 11 is communicated with the injection head 21; if L is too long, although it does not affect the realization of the function, it also increases the useless length of the front chamber barrel, and the syringe as a whole becomes long.

In some embodiments of the present invention, L satisfies that when the blocking plug 15 just fully enters the connecting cylinder 12 , all or part of the rubber plug 14 is still in the front chamber cylinder 11 .

In some embodiments of the present invention, L satisfies that when the blocking plug 15 just fully enters the connecting barrel 12 , the front chamber barrel 11 is not in communication with the injection head 21 .

3A and 3B, the connecting cylinder 12 is used to connect the front chamber cylinder 11 and the rear chamber cylinder 13, and the length H of the middle part of the connecting cylinder 12 is greater than the thickness of the blocking plug 15 (for example, the length H is 1.2-1. 1.8 times, preferably 1.5 times); preferably, the length H is less than the sum of the thicknesses of the blocking plug 15 and the push plug 16 . A communication groove 12a and a damping rib 12b are provided in the middle part of the connecting cylinder 12; the communication groove 12a is used to communicate the front chamber cylinder 11 and the rear chamber cylinder 13. When the blocking plug 15 slides to the middle part of the connecting cylinder 12, the front chamber cylinder 11 and the rear chamber cylinder The chamber tube 13 is connected; the number of the communication grooves 12a is 2 to 4, which should not be too much or too little. Operation; the damping rib 12b is used to increase the resistance of the blocking plug 15 passing through the connecting cylinder 12, to avoid excessive force during operation, and the blocking plug 15 directly rushes through the connecting cylinder 12, and cannot achieve the function of connecting the front chamber cylinder and the rear chamber cylinder; damping The number of ribs 12b is preferably four.

Without being bound by theoretical limitations, the diameter of the inner ring circled by the damping rib 12b of the connecting cylinder 12 is smaller than the outer diameter of the blocking plug 15 .

As shown in FIG. 4 , the container 102 composed of the rear chamber barrel 13, the blocking plug 15 and the push plug 16 can be used for pre-filling the injection 2; The length is M; preferably, the M length is 0.5 to 1 times the thickness of the blocking plug 15 .

Without being bound by the limitation of theory, in the process of assembling the syringe, M should not be 0, otherwise the blocking plug 15 will easily fall out due to accidental touch, or the blocking plug 15 will enter the connecting cylinder 12 due to accidental touch, resulting in the communication between the front and rear chambers; M should not be too long. , otherwise the overall length of the syringe will be too long. Therefore, the M length is preferably 0.5 to 1 times the thickness of the blocking plug 15 .

As shown in FIG. 1 , the push rod 32 is connected to the water suction ring 33 and the push plug 16 through the finger handle 31, and the diameter of the middle opening of the finger handle 31 is smaller than the diameter of the water suction ring 33 and the push plug 16, which can prevent the push rod 32 from being pulled out by mistake; When the push plug 16 passes through the middle part of the connecting cylinder 12, the water suction ring 33 can absorb the residual liquid in the communication groove 12a, so as to prevent the residual liquid from flowing out of the syringe.

As shown in FIGS. 5A, 5B and 5C, the inner diameter D of the inner cavity of the injection head 21 is 5% to 10% larger than the outer diameter of the rubber stopper 14, which can not only ensure that the syringe is easy to operate during injection, but also can reduce the amount of liquid to inject drugs. Residues in the syringe; the height N of the inner cavity of the injection head 21 is greater than the thickness of the rubber plug 14, which is about 1.2-1.4 times; the circumference and bottom of the inner cavity of the injection head 21 have grooves 21a, and the grooves 21a communicate with the needle nozzle 21c , its function is to ensure that the liquid can bypass the rubber stopper 14 and enter the injection needle 23, the number of grooves 21a is 2-4; there are ribs 21b around the inner cavity of the injection head 21, the number is 3-6, these ribs are equally spaced around the circumference Arranged, the diameter of the enclosed inner circle is equal to the diameter of the rubber stopper 14, and its function is to ensure that the rubber stopper 14 remains coaxial in the inner cavity of the injection head 21 (the rubber stopper 14 does not deflect in the injection head 21), so as to prevent the rubber stopper 14 from deflecting This results in excess injection fluid remaining in the cavity.

(2) About the charging method of the syringe

The sterilized front chamber barrel 11 and the rubber stopper 14 constitute a container 101. As shown in FIG. 2A, the container 101 contains a liquid medicine 1a, which is freeze-dried in a sterile and clean environment, and a solid block medicine is formed after freeze-drying, as shown in FIG. 2B. The state of the front chamber for loading lyophilized materials.

The sterilized rear chamber tube 13, the push plug 16, the finger handle 31, the push rod 32, and the water suction ring 33 are assembled to form a container 102, as shown in FIG. The liquid device dispenses the injection solution 2 into the container 102, and installs the blocking plug 15 after pipetting. Fig. 4 shows the state of the rear chamber for loading the injection solution.

Fig. 6 (the entire Fig. 6 is the syringe 10) is the state in which the front and rear chambers are connected through the connecting barrel 12, that is, the filling of the medicine and the injection liquid in the syringe 10 is completed; in a sterile and clean environment, continue to assemble the needle part assembly, Finally complete the assembly of the syringe.

(3) How to use the syringe/injection method

Fig. 7A shows the state of the syringe before use. When in use, the needle of the syringe is vertically upward, and the injection needle cover 24 is removed; the push rod 32 is pushed, and the rubber plug 14, the partition plug 15, the push plug 16 and the injection solution 2 in the syringe 10 move forward When the blocking plug 15 moves to the middle part of the connecting cylinder 12, as shown in FIG. 7B, the front chamber cylinder 11 and the rear chamber cylinder 13 are communicated through the communication groove 12a of the connecting cylinder 12; the push rod 32 continues to push, and the rubber plug 14 and The push plug 16 moves forward, the injection liquid 2 enters the front chamber barrel 11, the rubber plug 14 enters the inner cavity of the injection head 21, and the gas in the syringe barrel 10 is discharged through the injection needle 23, as shown in FIG. 7C; when the push plug 16 reaches the partition When plug 15, all the injection liquid 2 enters the front chamber barrel 11, and the freeze-dried drug 1b is mixed and dissolved with the injection liquid 2 to form the injection liquid 3, as shown in FIG. 7D; The air is expelled, resulting in a syringe ready for injection, as shown in Figure 7E.

Although specific embodiments of the present invention have been described in detail, those skilled in the art will understand. Various modifications and substitutions of those details may be made within the scope of the present invention in light of all the teachings disclosed. The full scope of the invention is given by the appended claims and any equivalents thereof.

Claims (19)

1. A syringe comprising an injection head (21), a syringe barrel (10), a push plug (16) and a push rod (32), wherein: The injection barrel (10) includes a front chamber barrel (11) and a rear chamber barrel (13), wherein the front chamber barrel (11) is detachable; Preferably, the antechamber (11) can be used to contain liquids and for lyophilization. 2. The syringe according to claim 1, wherein a rubber stopper (14) is provided in the front chamber barrel (11). 3. The syringe according to any one of claims 1 to 2, wherein the rear chamber barrel (13) has a blocking plug (15) close to the proximal end (13a) of the rear chamber barrel (13) for the front A partition between the chamber barrel (11) and the rear chamber barrel (13); and a push plug (16) located at the distal end (13b) of the rear chamber barrel (13). 4. The syringe according to claim 3, wherein the vertical distance from the rubber stopper (14) to the anterior chamber barrel (11) proximal end (11a) is represented as L, and L is 1-3 times of the thickness of the blocking plug 15; Preferably, L is 1.2-1.8 times the thickness of the partition plug 15; More preferably, L is 1.4-1.6 times the thickness of the blocking plug 15 . 5. The syringe according to any one of claims 1 to 4, wherein the front chamber barrel (11) and the rear chamber barrel (13) have the same diameter and are both independent tubes. 6. The syringe according to any one of claims 1 to 5, wherein the distal end (11b) of the anterior chamber barrel (11) and the proximal end (13a) of the posterior chamber barrel (13) are connected by a connecting barrel (12) ) connection, the diameter of the connecting cylinder (12) is the same as that of the front chamber cylinder (11) and the rear chamber cylinder (13). 7. The syringe according to claim 6, wherein the length of the middle part of the connecting cylinder (12) is represented as H, and H is 1.2-1.8 times the thickness of the blocking plug 15, preferably 1.4-1.6 times; Preferably, H is less than the sum of the thicknesses of the blocking plug 15 and the push plug 16 . 8. The syringe according to any one of claims 6 to 7, wherein one or more communication grooves (12a) are provided in the middle part of the connecting cylinder (12); the communication grooves (12a) are used to communicate with the front chamber cylinder (11) and the rear chamber cylinder (13), when the blocking plug (15) slides to the middle part of the connecting cylinder (12), the front chamber cylinder (11) and the rear chamber cylinder (13) are communicated; Preferably, the number of communication grooves (12a) is 1-6, more preferably 2, 3 or 4. 9. The syringe according to any one of claims 6 to 8, wherein one or more damping ribs (12b) are provided in the middle part of the connecting barrel (12); Preferably, the number of damping ribs (12b) is 1-6, more preferably 2, 3 or 4. 10. The syringe according to any one of claims 3 to 9, wherein the vertical distance from the blocking plug (15) to the proximal end (13a) of the rear chamber barrel (13) is represented as M, where M is the blocking plug (15) ) 0.5 to 1 times the thickness. 11. Syringe according to any one of claims 1 to 10, wherein the proximal end (10a) of the syringe barrel (10) is connected to the injection head (21). 12. The syringe of claim 11, wherein, The inner diameter D of the inner cavity of the injection head (21) is 5% to 10% larger than the outer diameter of the rubber stopper (14); and The inner cavity height N of the injection head (21) is greater than the thickness of the rubber stopper (14), preferably N is 1.2-1.4 times the thickness of the rubber stopper (14). 13. The syringe of any one of claims 11 to 12, wherein, There are grooves (21a) around and at the bottom of the inner cavity of the injection head (21), and the grooves (21a) communicate with the needle nozzle (21c), Preferably, there are 1-6 grooves (21a), preferably 2, 3 or 4 grooves. 14. The syringe according to any one of claims 11 to 13, wherein at least 2 ribs (21b) are arranged around the inner cavity of the injection head (21), the ribs are circumferentially arranged at equal intervals, and all the ribs surround The diameter of the inner circle is equal to the diameter of the rubber stopper (14); Preferably, the number of ribs is 3-12, preferably 3-6. 15. The syringe according to any one of claims 11 to 14, wherein the injection head (21) is connected to the injection needle seat (22); the injection needle seat (22) fixes the injection needle (23); Preferably, the injection head (21) and the injection needle seat (22) are connected in the form of threads; Preferably, the injection needle seat (22) is also connected to the injection needle cover (24). 16. Syringe according to any one of claims 1 to 15, wherein a push plug (16) in the rear chamber barrel (13) is connected to the push rod (32); Preferably, the push rod (32) and the push plug (16) are connected in the form of threads; Preferably, the distal end (10b) of the syringe (10) is connected with a finger handle (31); Preferably, the finger handle (31 and the push rod (32) constitute the structure of the syringe for one-handed injection operation; Preferably, there is a water suction ring (33) on the side of the push rod (32) close to the push plug (16), and the push rod (32) is connected to the water suction ring (33) and the push plug (16) through the finger handle (31). ; Preferably, the diameter of the middle opening of the finger handle (31) is smaller than the diameters of the water suction ring (33) and the push plug (16). 17. The syringe according to any one of claims 1 to 16, wherein the container (101) formed by the front chamber barrel (11) and the rubber stopper (14) can be used to hold liquid medicines and freeze-dried; Preferably, the solid drug obtained after lyophilization can be directly used for packaging of the syringe. 18. Syringe according to any one of claims 1 to 17, wherein the rear chamber barrel (13) and the blocking plug (15) and the push plug (16) constitute a container (102) that can be used for prefilled injections liquid. 19. The charging method of the syringe according to any one of claims 1 to 18, comprising the steps of: ① The sterilized front chamber barrel (11) or the container (101) formed by the sterilized front chamber barrel (11) and the rubber stopper (14) is filled with solid medicine or liquid medicine; Freeze-dried in a clean environment to obtain solid drug after freeze-drying; ② Assemble the sterilized rear chamber cylinder (13), push plug (16), optional finger handle (31), push rod (32) and optional water suction ring (33) to form a container (102) ; ③ In a sterile and clean environment, sub-fill the injection solution into the container (102), and then install the partition plug (15) after pipetting.

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