CN114651819A - Organic disinfectant based on marine resources - Google Patents
Organic disinfectant based on marine resources Download PDFInfo
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- CN114651819A CN114651819A CN202210234045.XA CN202210234045A CN114651819A CN 114651819 A CN114651819 A CN 114651819A CN 202210234045 A CN202210234045 A CN 202210234045A CN 114651819 A CN114651819 A CN 114651819A
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- disinfectant
- marine resources
- organic
- quaternary ammonium
- organic disinfectant
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- 239000000645 desinfectant Substances 0.000 title claims abstract description 60
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 17
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 14
- 125000002091 cationic group Chemical group 0.000 claims abstract description 14
- 229920001661 Chitosan Polymers 0.000 claims abstract description 11
- 102000016943 Muramidase Human genes 0.000 claims abstract description 10
- 108010014251 Muramidase Proteins 0.000 claims abstract description 10
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 10
- 229960000274 lysozyme Drugs 0.000 claims abstract description 10
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 10
- 239000004325 lysozyme Substances 0.000 claims abstract description 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 8
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 7
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 7
- 239000011718 vitamin C Substances 0.000 claims abstract description 7
- 241000239366 Euphausiacea Species 0.000 claims abstract description 6
- 102000007327 Protamines Human genes 0.000 claims abstract description 6
- 108010007568 Protamines Proteins 0.000 claims abstract description 6
- -1 alkyl dimethyl ammonium chloride Chemical compound 0.000 claims abstract description 6
- 229960001950 benzethonium chloride Drugs 0.000 claims abstract description 6
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 claims abstract description 6
- 229940048914 protamine Drugs 0.000 claims abstract description 6
- 229960000686 benzalkonium chloride Drugs 0.000 claims abstract description 4
- XIWFQDBQMCDYJT-UHFFFAOYSA-M benzyl-dimethyl-tridecylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 XIWFQDBQMCDYJT-UHFFFAOYSA-M 0.000 claims abstract description 4
- WLCFKPHMRNPAFZ-UHFFFAOYSA-M didodecyl(dimethyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCC WLCFKPHMRNPAFZ-UHFFFAOYSA-M 0.000 claims abstract description 4
- 238000003756 stirring Methods 0.000 claims description 12
- 238000006243 chemical reaction Methods 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- 230000001502 supplementing effect Effects 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 241000894006 Bacteria Species 0.000 abstract description 12
- 241000700605 Viruses Species 0.000 abstract description 8
- 241000233866 Fungi Species 0.000 abstract description 5
- 150000001768 cations Chemical class 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 43
- 238000012360 testing method Methods 0.000 description 11
- 239000002131 composite material Substances 0.000 description 9
- 241000588724 Escherichia coli Species 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 230000003472 neutralizing effect Effects 0.000 description 8
- 239000011550 stock solution Substances 0.000 description 8
- 241000222122 Candida albicans Species 0.000 description 7
- 241000191967 Staphylococcus aureus Species 0.000 description 7
- 229940095731 candida albicans Drugs 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 5
- 239000003085 diluting agent Substances 0.000 description 5
- 239000000047 product Substances 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 244000005700 microbiome Species 0.000 description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- KFSLWBXXFJQRDL-UHFFFAOYSA-N Peracetic acid Chemical compound CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 2
- 230000000249 desinfective effect Effects 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 238000013095 identification testing Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000989 no adverse effect Toxicity 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 description 1
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 239000005708 Sodium hypochlorite Substances 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- KCXMKQUNVWSEMD-UHFFFAOYSA-N benzyl chloride Chemical compound ClCC1=CC=CC=C1 KCXMKQUNVWSEMD-UHFFFAOYSA-N 0.000 description 1
- 229940073608 benzyl chloride Drugs 0.000 description 1
- 230000008033 biological extinction Effects 0.000 description 1
- 230000005540 biological transmission Effects 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
Images
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/46—N-acyl derivatives
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/14—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings
- A01N43/16—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom six-membered rings with oxygen as the ring hetero atom
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N61/00—Biocides, pest repellants or attractants, or plant growth regulators containing substances of unknown or undetermined composition, e.g. substances characterised only by the mode of action
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N63/00—Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
- A01N63/10—Animals; Substances produced thereby or obtained therefrom
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
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Abstract
The invention discloses an organic disinfectant based on ocean resources, and relates to the technical field of disinfectants; each 1L of the disinfectant comprises the following components in percentage by weight: cationic peptide: 0.05 g to 0.2 g, lysozyme: 0.5 g-2 g, quaternary ammonium salt: 20-120 g, vitamin C: 0.2 g-20 g, low molecular chitosan: 0.1-10 g, water: and (3) complementing the balance, wherein the cationic peptides comprise but are not limited to protamine and antarctic krill cationic peptides, the molecular weight of the low-molecular chitosan is less than 3000D, and the quaternary ammonium salts are 5-10 g of benzethonium chloride, 5-30 g of alkyl dimethyl ammonium chloride, 5-30 g of didodecyl dimethyl ammonium chloride and 10-50 g of benzalkonium chloride. One or two single-chain or double-chain quaternary ammonium salts of the cation membrane-penetrating peptide, the lysozyme and the quaternary ammonium salt have short time for killing viruses, bacteria and fungi, quick response, nonflammability and lower potential safety hazard.
Description
Technical Field
The invention relates to the technical field of disinfectants, in particular to an organic disinfectant based on ocean resources.
Background
In the daily life of human beings, various microorganisms and viruses are inevitably exposed, and the microorganisms and viruses can directly or indirectly cause harm to the human body, so that disinfection and sterilization are recognized as necessary measures for cutting off the transmission path of infectious diseases.
The existing disinfection products are mainly divided into environmental disinfection, conventional hand and foot disinfection liquid and wound disinfection liquid; the environment disinfection type disinfectant is mainly applied to conventional disinfection and sterilization in epidemic prevention and disaster areas, and disinfection of public places such as swimming pools, hotels, restaurants, families, schools, hospitals and the like, and comprises alcohol, 84 disinfectant, peracetic acid, and sodium bicarbonate, and the like, the traditional chemical disinfection products are not ideal in the aspects of sterilization effect, virulence factors and the like, and the disinfectant has weak quick killing capability, poor killing capability on viruses, spores and mixed bacteria, and poor anti-interference performance on organic matters.
Alcohol is inflammable and explosive, easily causes accidents such as fire disasters and the like, and is not suitable for large-area disinfection, and chlorine-containing disinfectants such as sodium hypochlorite have strong irritation and corrosivity, and are easy to generate toxic and harmful substances such as chlorine and the like if being diluted or used improperly, so that personnel are damaged, and the environmental safety and the object corrosion are influenced.
The effect of the compound formula of biological disinfector such as enzyme and peptide compound quaternary ammonium salt is better.
Therefore, the invention provides an organic disinfectant based on marine resources.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides an organic disinfectant based on marine resources.
In order to achieve the purpose, the invention adopts the following technical scheme:
an organic disinfectant based on marine resources, wherein each 1L of disinfectant comprises the following components in parts by weight: cationic peptide: 0.05 g to 0.2 g, lysozyme: 0.5 g-2 g, quaternary ammonium salt: 20-120 g, vitamin C: 0.2 g-20 g, low molecular chitosan: 0.1 g to 10 g, water: and (5) complementing the balance.
Preferably: the cationic peptides include, but are not limited to, protamine and antarctic krill cationic peptides.
Preferably: the molecular weight of the low molecular chitosan is less than 3000D.
Preferably: the quaternary ammonium salt is one or a mixture of 5-10 g of benzethonium chloride, 5-30 g of alkyl dimethyl ammonium chloride, 5-30 g of didodecyl dimethyl ammonium chloride and 10-50 g of benzalkonium chloride.
Preferably: the preparation method of the organic disinfectant comprises the following steps:
s1: weighing the materials according to the proportion and putting the materials into a reaction kettle;
s2: adding clear water 70-80% of the total amount;
s3: stirring under normal pressure, and heating the reaction kettle;
s4: keeping the temperature and standing for 0.2-1h, and fully dissolving and reacting the disinfectant components;
s5: and (5) supplementing the residual water amount, and stirring to obtain the compound disinfectant.
Preferably: in S3, the temperature is increased at a rate of 3-5 ℃/min.
Preferably: in the S3, the highest heating temperature is 70-80 ℃.
Preferably: in the S3, the stirring speed is 1000-1500 rpm.
Preferably: in the S5, the stirring speed is 300-500 rpm.
The invention has the beneficial effects that:
1. the invention uses one or two single-chain or double-chain quaternary ammonium salts of cation membrane-penetrating peptide (less than 30 amino acids), lysozyme and quaternary ammonium salt, has short time for killing virus, bacteria and fungi, takes effect quickly, is not flammable and has lower potential safety hazard.
2. The invention can effectively kill enveloped virus, bacteria (represented by staphylococcus aureus and escherichia coli), fungi (represented by candida albicans) and the like. The surface air and object disinfecting and killing device can meet the large-scale air and object surface disinfecting and killing requirements of public places such as airports, stations, subways and the like, and is also suitable for households, offices, vehicles, pets and the like.
3. The invention adopts a common mixing form, but in the aspect of proportioning, a secondary water adding mode is adopted, the primary water is used as a solvent to dissolve various components, and the secondary water is used as a supplement, so that the influence of the dissolution of various components and the total volume of the disinfectant in the reaction process is reduced, and the conformity and the accuracy of various proportioning and the designed proportioning are improved.
Drawings
FIG. 1 is a schematic flow chart of a preparation method of an organic disinfectant based on marine resources, which is provided by the invention;
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
In the description of this patent, it is noted that unless otherwise specifically stated or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly and can include, for example, fixedly connected, disposed, detachably connected, disposed, or integrally connected and disposed. The specific meaning of the above terms in this patent may be understood by those of ordinary skill in the art as appropriate.
An organic disinfectant based on marine resources, wherein each 1L of disinfectant comprises the following components in parts by weight: cationic peptide: 0.05 g to 0.2 g, lysozyme: 0.5 g-2 g, quaternary ammonium salt: 20-120 g, vitamin C: 0.2 g-20 g, low molecular chitosan: 0.1 g to 10 g, water: and (5) complementing the balance.
The cationic peptides include, but are not limited to, protamine and antarctic krill cationic peptides.
The molecular weight of the low molecular chitosan is less than 3000D.
The quaternary ammonium salt is one or a mixture of 5-10 g of benzethonium chloride, 5-30 g of alkyl dimethyl ammonium chloride, 5-30 g of didodecyl dimethyl ammonium chloride and 10-50 g of benzalkonium chloride.
The preparation method of the organic disinfectant comprises the following steps:
s1: weighing the materials according to the proportion and putting the materials into a reaction kettle;
s2: adding clear water 70-80% of the total amount;
s3: stirring under normal pressure, and heating the reaction kettle;
s4: keeping the temperature and standing for 0.2-1h, and fully dissolving and reacting the disinfectant components;
s5: and (5) supplementing the residual water amount, and stirring to obtain the compound disinfectant.
In the step S3, heating is carried out at a speed of 3-5 ℃/min, and the highest temperature is controlled to be 70-80 ℃.
In the S3, the stirring speed is 1000-1500rpm, and in the S5, the stirring speed is 300-500 rpm.
According to the invention, one or two single-chain or double-chain quaternary ammonium salts of the cation cell-penetrating peptide (less than 30 amino acids), lysozyme and quaternary ammonium salt are used, so that the time for killing viruses, bacteria and fungi is short, the effect is fast, the material is non-flammable, and the potential safety hazard is low; the invention can effectively kill enveloped virus, bacteria (represented by staphylococcus aureus and escherichia coli), fungi (represented by candida albicans) and the like. The disinfectant can meet the large-scale air and object surface disinfection requirements of public places such as airports, stations, subways and the like, is also suitable for households, offices, vehicles, pets and the like, adopts a common mixing mode in the preparation method, but adopts a secondary water adding mode in the aspect of proportioning, the primary water is used as a solvent to dissolve various components, and the secondary water is used as a supplement, so that the influence of the dissolution and reaction processes of the components on the total volume of the disinfectant is reduced, and the degree of agreeing with and the accuracy of the proportioning and the design proportioning are improved.
Example 1:
an organic disinfectant based on marine resources, wherein each 1L of disinfectant comprises the following components in parts by weight: protamine: 0.05 g, lysozyme: 0.5 g, quaternary ammonium salt: 5g, vitamin C: 0.2 g, low molecular chitosan: 0.1 g, water: and (5) complementing the balance.
The quaternary ammonium salt is benzethonium chloride.
Example 2:
an organic disinfectant based on marine resources, wherein each 1L of disinfectant comprises the following components in parts by weight: 0.05 g of cationic peptide of Antarctic krill, lysozyme: 0.5 g, quaternary ammonium salt: 5g, vitamin C: 0.2 g, low molecular chitosan: 0.1 g, water: and (5) complementing the balance.
The quaternary ammonium salt is benzethonium chloride.
Example 3:
an organic disinfectant based on marine resources, wherein each 1L of disinfectant comprises the following components in parts by weight: protamine 0.05 g, antarctic krill cationic peptide 0.05 g, lysozyme: 1 g, quaternary ammonium salt: 10 g, vitamin C: 5g, low molecular chitosan: 2 g, water: and (5) complementing the balance.
The quaternary ammonium salt is 5g of benzyl chloride and 5g of alkyl dimethyl ammonium chloride.
And (3) disinfection effect experiment:
selecting and using the following sterilization bacteria: escherichia coli (8099) is obtained by taking the 8 th generation fresh slant culture, staphylococcus aureus (ATCC 6538), the 8 th generation fresh slant culture and pseudomonas aeruginosa (ATCC 15442) and the 8 th generation fresh slant culture, wherein the strains are provided by food microorganism safety engineering research and development center of Guangdong province.
Basis of examination
GB 27951-plus 2011 appendix A of skin disinfectant sanitary requirements
Disinfection Specification (2002 edition) 2.1.1.5.5
Disinfection technical Specification (2002 edition) 2.1.1.7
Disinfection technical Specification (2002 edition) 2.1.1.9
Disinfection Specification (2002 edition) 2.1.2.6
Disinfection Specification (2002 edition) 2.1.2.8
Disinfection Specification (2002 edition) 2.1.2.10
Disinfection Specification (2002 edition) 2.1.3.4
Disinfection Specification (2002 edition) 2.1.3.5
Basis of evaluation
GB 27951-
Disinfection technical Specification (2002 year edition)
Test conclusion
1. The total colony number of the composite disinfectant stock solution is less than 10CFU/mL, the mould and the microzyme are less than 10CFU/mL, and beta hemolytic streptococcus, pseudomonas aeruginosa and staphylococcus aureus are not detected, thereby meeting the standard requirements of GB 27951 plus 2011 sanitary requirements for skin disinfectants.
2. The identification test of the neutralizing agent shows that the D/E neutralizing broth can effectively neutralize the bactericidal effect of the composite disinfectant stock solution on the escherichia coli (8099), and the neutralizing agent and the neutralization product have no adverse effect on the escherichia coli (8099) and a culture medium, which shows that the neutralizing agent is suitable for quantitative killing tests of the escherichia coli (8099), the staphylococcus aureus (ATCC 6538) and the pseudomonas aeruginosa (ATCC 15442).
3. According to the technical specification for disinfection (2002 edition), under experimental conditions, the average killing logarithm value of the composite disinfectant stock solution on escherichia coli (8099), staphylococcus aureus (ATCC 6538) and pseudomonas aeruginosa (ATCC 15442) is more than 5.00 after 1min of action; the disinfectant diluent (diluted by 10 times) acts for 10min, and the average killing log values of escherichia coli (8099), staphylococcus aureus (ATCC 6538) and pseudomonas aeruginosa (ATCC 15442) are all greater than 5.00, thereby meeting the standard requirements of the disinfection technical specification (2002 edition).
4. The identification test of the neutralizing agent shows that the D/E neutralizing broth can effectively neutralize the bactericidal effect of the composite disinfectant stock solution on the Candida albicans (ATCC 10231), and the neutralizing agent and the neutralized product have no adverse effect on the Candida albicans (ATCC 10231) and a culture medium, which shows that the neutralizing agent is suitable for the quantitative killing test of the Candida albicans (ATCC 10231).
5. According to the technical specification for disinfection (2002 edition), under experimental conditions, the average killing logarithm value of the composite disinfectant stock solution on candida albicans (ATCC 10231) is more than 4.00 after 1min of action; the average log kill value of the compound disinfectant diluent (diluted 10 times) on candida albicans (ATCC 10231) for 10min is > 4.00. Meets the standard requirements of disinfection technical specification (2002 edition).
6. The hand disinfection field test shows that under the experimental condition, the composite disinfectant stock solution acts for 1min
The average killing logarithm value of the natural bacteria on the surfaces of the hands (sanitary hands) of 30 testees is more than 1.00, and the standard requirement of disinfection technical specification (2002 edition) is met.
7. A hand disinfection field test shows that under the experimental conditions, the average killing logarithm value of the natural bacteria on the surfaces of the hands (surgical hands) of 30 testees is more than 1.00 after the compound disinfectant stock solution acts for 3min, and the standard requirement of disinfection technical specification (2002 edition) is met.
8. The skin disinfection field test shows that under the experimental condition, the average killing logarithm value of the natural bacteria on the skin surface of 30 subjects under the action of the composite disinfectant stock solution for 1min is more than 1.00, and the standard requirement of disinfection technical specification (2002 edition) is met.
9. The field test of the disinfection of the surface of the wooden object shows that under the experimental condition, the composite disinfectant diluent (diluted by 10 times) acts for 10min, the average killing logarithm value of the natural bacteria on the surface of the wooden object is more than 1.00, and the standard requirement of the disinfection technical specification (2002 edition) is met.
10. The result of an air disinfection effect simulation field test shows that in a closed space of 20m3, under the experimental conditions, the compound disinfectant diluent (diluted by 10 times) is sprayed in the closed space at the concentration of 10mL/m3 for 60min, the killing rate of the white staphylococcus is more than 99.90 percent after 3 times of test results, and the requirements of disinfection technical specification (2002 edition) on qualified disinfection are met.
11. The field test result of the air disinfection effect shows that in a room of 30m3, under the experimental condition, the composite diluent (diluted by 10 times) is atomized into the air at the concentration of 10mL/m3, the 3 times of test results of the air natural bacteria extinction rate after 60min are all more than 90%, and the air disinfection effect meets the standard requirement of disinfection technical specification (2002 edition).
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. An organic disinfectant based on marine resources is characterized in that each 1L of disinfectant comprises the following components in parts by weight: cationic peptide: 0.05 g to 0.2 g, lysozyme: 0.5 g-2 g, quaternary ammonium salt: 20-120 g, vitamin C: 0.2-20 g, low molecular chitosan: 0.1 g to 10 g, water: and (5) complementing the balance.
2. The organic disinfectant based on marine resources as claimed in claim 1, wherein said cationic peptides include, but are not limited to protamine and antarctic krill cationic peptides.
3. The organic disinfectant based on marine resources as recited in claim 1, wherein said low molecular chitosan has a molecular weight of less than 3000D.
4. The marine resource-based organic disinfectant as recited in claim 1, wherein said quaternary ammonium salt is one or more of benzethonium chloride 5-10 g, alkyl dimethyl ammonium chloride 5-30 g, didodecyl dimethyl ammonium chloride 5-30 g, benzalkonium chloride 10-50 g.
5. The organic disinfectant based on marine resources as claimed in any one of claims 1 to 4, wherein the preparation method of the organic disinfectant comprises the following steps:
s1: weighing the materials in proportion and putting the materials into a reaction kettle;
s2: adding clear water 70-80% of the total amount;
s3: stirring under normal pressure, and heating the reaction kettle;
s4: keeping the temperature and standing for 0.2-1h, and fully dissolving and reacting the disinfectant components;
s5: and (5) supplementing the residual water amount, and stirring to obtain the compound disinfectant.
6. The organic disinfectant based on marine resources as set forth in claim 5, wherein in said S3, heating is performed at a rate of 3-5 ℃/min.
7. The organic disinfectant based on marine resources as set forth in claim 6, wherein said S3 is heated at a maximum temperature of 70-80 ℃.
8. The organic disinfectant based on marine resources as claimed in claim 5, wherein in said S3, the stirring speed is 1000-1500 rpm.
9. The organic disinfectant based on marine resources as claimed in claim 8, wherein in said S5, the stirring speed is 300-500 rpm.
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