CN114569526B - Anti-wrinkle whitening essence and preparation method thereof - Google Patents
Anti-wrinkle whitening essence and preparation method thereof Download PDFInfo
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- CN114569526B CN114569526B CN202210201325.0A CN202210201325A CN114569526B CN 114569526 B CN114569526 B CN 114569526B CN 202210201325 A CN202210201325 A CN 202210201325A CN 114569526 B CN114569526 B CN 114569526B
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- 230000001153 anti-wrinkle effect Effects 0.000 title claims abstract description 27
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 57
- 229920001661 Chitosan Polymers 0.000 claims abstract description 55
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 54
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- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims abstract description 27
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 23
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- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/29—Titanium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/733—Alginic acid; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/736—Chitin; Chitosan; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Inorganic Chemistry (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
Abstract
The application discloses anti-wrinkle whitening essence and a preparation method thereof; the anti-wrinkle whitening essence comprises the following materials in percentage by mass: 5-10% of composite angelica extract, 0.1-0.5% of ginseng extract, 0.1-0.5% of coix seed extract, 0.1-0.5% of safflower extract, 1-3% of polypeptide, 1-5% of chitosan microsphere, 0.1-0.5% of honeysuckle leaf extract, 0.02-0.05% of citric acid, 0.4-1% of hydroxyethyl cellulose and 2-5% of 1, 2-propylene glycol, and adding deionized water to 100%; the compound radix Angelicae sinensis extract is a mixture of radix Paeoniae alba, radix Angelicae sinensis, aloe and Glycyrrhrizae radix extracts. The components of the application are mostly Chinese medicines, the skin allergy phenomenon can not occur when the vitamin E is added into the Chinese medicine, the vitamin E is coated by the composite wall material, the effect of the vitamin E can not be influenced, and the vitamin E can be placed for a long time. The essence prepared by the application has the effects of resisting wrinkles, whitening, moisturizing, resisting oxidation and preventing sunburn, and the adopted components cannot cause damage to skin, so that the essence is nontoxic and harmless.
Description
Technical Field
The application relates to the technical field of essence preparation, in particular to anti-wrinkle whitening essence and a preparation method thereof.
Background
The material life of the current society is becoming more and more abundant, and women have higher and higher requirements on appearance, and the appearance of the women is usually improved by a skin care mode. In skin care products, most women have high requirements on essence, and the essence with various properties is often the first choice of women.
With the age of women, the problem of skin aging is more serious, and usually accompanied by the generation of wrinkles and spots, whitening and moisturizing essence is purchased for women under 25 years old, and spot-lightening and anti-wrinkle essence is selected for women over 25 years old.
The existing essence on the market has few essences and has the effects, and in order to enhance the effects, a large amount of chemical synthetic products are often selected to be added, and the chemical synthetic products can bring side effects to skin, such as allergic dermatitis, photo anaphylactic reaction and the like, so that the production of the essence meeting the requirements is an urgent problem to be solved.
Disclosure of Invention
The application aims to provide anti-wrinkle whitening essence and a preparation method thereof, which aim to solve the problems in the background technology.
In order to solve the technical problems, the application provides the following technical scheme:
the anti-wrinkle whitening essence comprises the following materials in percentage by mass: 5-10% of composite angelica extract, 0.1-0.5% of ginseng extract, 0.1-0.5% of coix seed extract, 0.1-0.5% of safflower extract, 1-3% of polypeptide, 1-5% of chitosan microsphere, 0.1-0.5% of honeysuckle leaf extract, 0.02-0.05% of citric acid, 0.4-1% of hydroxyethyl cellulose and 2-5% of 1, 2-propylene glycol, and deionized water is added to 100%.
In a further optimized scheme, the compound angelica extract is a mixture of white peony root, angelica, aloe and licorice extracts.
According to a further optimized scheme, the preparation method of the anti-wrinkle whitening essence comprises the following steps of:
s1: extracting radix Paeoniae alba with 80% ethanol under microwave for 5-10min; extracting radix Angelicae sinensis and Glycyrrhrizae radix with deionized water under microwave for 5-10min, cleaning folium Aloe, cutting, grinding, soaking in diethyl ether solution for 4-6 hr, vacuum filtering, adding absolute ethanol, soaking for 22-25 hr, vacuum distilling, adsorbing to remove bitter components, concentrating, and mixing with the extracted radix Paeoniae alba, radix Angelicae sinensis and Glycyrrhrizae radix to obtain compound radix Angelicae sinensis extract;
s2: sieving flos Lonicerae leaf with 200-800 mesh sieve, adding absolute ethanol, performing water bath reaction, and vacuum filtering to obtain solution as flos Lonicerae leaf extract;
s3: dissolving sodium alginate in deionized water, adding vitamin E and nano calcium carbonate, uniformly mixing, performing ultrasonic reaction for 0.5-2h, adding a mixture of liquid paraffin and tween 80, uniformly mixing, slowly adding a mixed solution of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding an aqueous solution of modified chitosan, uniformly mixing, reacting for 30-60min, washing, centrifuging, freeze-drying, dissolving in deionized water, adding organic montmorillonite and titanium dioxide, performing microwave radiation reaction for 2h, dialyzing and freeze-drying to obtain chitosan microspheres;
s4: uniformly mixing 1, 2-propylene glycol, citric acid, ginseng extract, coix seed extract, safflower extract, chitosan microsphere, honeysuckle leaf extract and deionized water, adding hydroxyethyl cellulose, heating to 60-80 ℃, reacting for 1-2h, cooling to room temperature, adding the compound angelica extract and polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
In a further optimized scheme, in the step S2, the content of absolute ethyl alcohol is 60%, the mass ratio of honeysuckle leaves to absolute ethyl alcohol is 1:12, the reaction temperature is 60-70 ℃, and the reaction time is 4-5h.
In a further optimized scheme, in the step S3, the preparation method of the modified chitosan comprises the following steps: dissolving chitosan in acetic acid solution, adding succinic anhydride, mixing uniformly, regulating the pH value of the solution to 7-8, reacting for 6-8h, adding absolute ethyl alcohol, filtering, extracting for 20-25h, and drying to obtain the modified chitosan.
In a further optimized scheme, in the step S1, the microwave extraction power of the white paeony root is 400W; the microwave extraction power of the angelica and the liquorice is 800W.
In a further optimized scheme, the microwave radiation power is 800W and the radiation temperature is 85 ℃.
The alcohol extract of the honeysuckle leaves is used as the honeysuckle leaf extract, has the reactions of no toxicity, no harm, no allergy, no stimulation and the like, can avoid the safety problem existing in the synthesis of the honeysuckle leaf extract, contains a large amount of flavonoid substances, has the functions of antioxidation, antibiosis, antiphlogosis and the like, utilizes absolute ethyl alcohol to extract the flavonoid substances in the honeysuckle leaves, has high inhibition rate of the flavonoid substances on bacteria, has stronger antibiosis, adopts the absolute ethyl alcohol as the extract, and can avoid the influence of impurities such as starch or inorganic salt and the like in the extract when deionized water is used as the extract. In addition, the application limits the content of the absolute ethyl alcohol to 60%, the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol to 1:12, the reaction temperature to 60-70 ℃ and the reaction time to 4-5h, and can improve the extraction quantity of flavonoid substances, thereby improving the bacteriostasis of essence. The flavonoid has strong antioxidant property, can consume free radicals generated by long-time placement of essence, and can prolong whitening and anti-wrinkle effects of the essence.
The extracts of the white paeony root, the Chinese angelica, the aloe and the liquorice are compounded to prepare the compound Chinese angelica extract, and the compound Chinese angelica extract is added into the essence, so that the effects of whitening and spot-lightening of the essence can be endowed. Radix Paeoniae alba has antiinflammatory effect, can be used for treating acne and comedo of face, and radix Angelicae sinensis contains abundant amino acids and inorganic salts, and has effects of promoting skin metabolism and keeping skin clean, aloe contains abundant vitamins and amino acids, has effects of spot fading, antiinflammatory and nourishing skin, and Glycyrrhrizae radix can remove melanin, has whitening effect, and has moisture keeping effect. Extracts of ginseng, coix seed and safflower are added as natural moisturizer, and when the natural moisturizer is used, the extracts can increase moisture of horny layer and repair barrier. The polypeptide has anti-wrinkle effect.
The chitosan reacts with the succinic anhydride, and the amino group reacts with the carboxyl group to generate succinyl chitosan, so that the solubility of the chitosan is improved, then the chitosan reacts with titanium dioxide, the titanium dioxide can be fixed on the surface of the chitosan and is not easy to fall off, the chitosan can absorb ultraviolet rays under various wave bands, and the sun-proof performance of the essence is improved.
The sodium alginate is used for coating the vitamin E, the vitamin E has the effects of resisting oxidation and delaying skin aging, but the vitamin E makes oil-soluble substances insoluble in water and exposed in air, is easily damaged by ultraviolet rays and loses the performance of the vitamin E, so that the sodium alginate is coated with the vitamin E, the dissolubility of the microorganism E is improved, the damage by the ultraviolet rays is avoided, the slow release effect is achieved, the modified chitosan and the sodium alginate are compounded into a composite wall material for preventing the vitamin E from being leaked when the sodium alginate is independently coated with the vitamin E, the vitamin E is coated, the excellent dissolubility and biocompatibility of the modified chitosan are utilized, the coating rate of the vitamin E is improved, the leakage of the vitamin E is avoided, the modified chitosan and the sodium alginate are crosslinked with calcium carbonate, a network structure is formed, and the chitosan can fill micropores on the surface of the sodium alginate microsphere and strengthen the wall material. When the vitamin E is coated on the composite wall material, the effect of the vitamin E is not affected because of physical coating, so that the composite microsphere still has the effects of antioxidation, whitening and sun protection. Finally, the composite microspheres are intercalated between montmorillonite sheets, and the montmorillonite is added into the fine flower by utilizing the adsorption of montmorillonite, so that the face grease and toxin can be adsorbed when the face cream is used, and meanwhile, the moisture retention of essence can be improved by the montmorillonite.
Compared with the prior art, the application has the following beneficial effects: the essence prepared by the application has the effects of resisting wrinkles, whitening, moisturizing, resisting oxidation and preventing sunburn, and the adopted components cannot cause damage to skin, so that the essence is nontoxic and harmless.
Detailed Description
The following description of the technical solutions in the embodiments of the present application will be clear and complete, and it is obvious that the described embodiments are only some embodiments of the present application, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the application without making any inventive effort, are intended to be within the scope of the application.
Example 1: a preparation method of anti-wrinkle whitening essence comprises the following steps:
s1: setting the microwave extraction power to 400W, and extracting 10 parts of white paeony root for 5min by using 60 parts of 80% ethanol microwave; setting the microwave extraction power to be 800W, carrying out microwave extraction on 10 parts of angelica and 10 parts of liquorice for 5min by using 120 parts of deionized water, washing, chopping and grinding aloe leaves, soaking in 100 parts of diethyl ether solution for 4h, carrying out suction filtration, adding 300 parts of 95% absolute ethyl alcohol, continuously soaking for 22h, carrying out reduced pressure distillation, adsorbing to remove bitter components, concentrating at low temperature, and uniformly mixing with the extracted white paeony root, angelica and liquorice to obtain the composite angelica extract; the mass ratio of the aloe to the white paeony root, the angelica and the liquorice after extraction is 1:1:1:1;
s2: soaking Ginseng radix in 70% absolute ethanol solution, reacting for 0.5 hr, refluxing for 2 hr, filtering, and concentrating the filtrate to obtain Ginseng radix extractive solution; soaking Carthami flos in deionized water, performing ultrasonic reaction for 0.5 hr, filtering, retaining residue, adding deionized water, performing ultrasonic reaction for 0.5 hr, filtering, and collecting filtrate of mobile phone to obtain Carthami flos extract; soaking semen Persicae in deionized water, boiling, reacting for 0.5 hr, and filtering to obtain semen Persicae extract;
s3: sieving flos Lonicerae leaf with 800 mesh sieve, adding 60% absolute ethanol, reacting in water bath at 60deg.C for 4 hr, and vacuum filtering to obtain solution as flos Lonicerae leaf extract; the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1:12;
s4: dissolving 1 part of chitosan in 50 parts of 1% acetic acid solution, reacting for 1h, adding 2 parts of succinic anhydride, uniformly mixing, adjusting the pH value of the solution to 7, reacting for 6h, adding 100 parts of absolute ethyl alcohol, filtering, extracting for 20h, and drying to obtain modified chitosan;
s5: dissolving 15 parts of sodium alginate in 20 parts of deionized water, adding 7 parts of vitamin E and 5 parts of nano calcium carbonate, uniformly mixing, performing ultrasonic reaction for 0.5h, adding a mixture of 5 parts of liquid paraffin and 3 parts of tween 80, uniformly mixing, slowly adding a mixed solution of 10 parts of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding 100 parts of modified chitosan aqueous solution, uniformly mixing, reacting for 30min, washing with deionized water, centrifuging, freeze-drying, adding 150 parts of deionized water, reacting with 10 parts of 0.1% swelled organic montmorillonite and 0.2 part of titanium dioxide, performing microwave radiation reaction for 2h at a microwave power of 800W at a temperature of 85 ℃, dialyzing, and freeze-drying at a temperature of minus 50 ℃ to obtain the chitosan microspheres;
s6: uniformly mixing 2% of 1, 2-propylene glycol, 0.02% of citric acid, 0.1% of ginseng extract, 0.1% of coix seed extract, 0.1% of safflower extract, 1% of chitosan microsphere, 0.1% of honeysuckle leaf extract and 90.18% of deionized water, adding 0.4% of hydroxyethyl cellulose, heating to 60 ℃, reacting for 1h, cooling to room temperature, adding 5% of compound angelica extract and 1% of polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
Example 2: a preparation method of anti-wrinkle whitening essence comprises the following steps:
s1: setting the microwave extraction power to 400W, and extracting 11 parts of white paeony root for 6min by using 70 parts of 80% ethanol microwave; setting the microwave extraction power to be 800W, carrying out microwave extraction on 10 parts of angelica and 10 parts of liquorice for 6min by using 120 parts of deionized water, washing, chopping and grinding aloe leaves, soaking in 105 parts of diethyl ether solution for 4.5h, carrying out suction filtration, adding 350 parts of 95% absolute ethyl alcohol, continuously soaking for 23h, carrying out reduced pressure distillation, adsorbing to remove bitter components, concentrating at low temperature, and uniformly mixing with the extracted white paeony root, angelica and liquorice to obtain the composite angelica extract; the mass ratio of the aloe to the white paeony root, the angelica and the liquorice after extraction is 1:1:1:1;
s2: soaking Ginseng radix in 70% absolute ethanol solution, reacting for 0.5 hr, refluxing for 2 hr, filtering, and concentrating the filtrate to obtain Ginseng radix extractive solution; soaking Carthami flos in deionized water, performing ultrasonic reaction for 0.5 hr, filtering, retaining residue, adding deionized water, performing ultrasonic reaction for 0.5 hr, filtering, and collecting filtrate of mobile phone to obtain Carthami flos extract; soaking semen Persicae in deionized water, boiling, reacting for 0.5 hr, and filtering to obtain semen Persicae extract;
s3: sieving flos Lonicerae leaf with 800 mesh sieve, adding 60% absolute ethanol, reacting in water bath at 62deg.C for 4.2 hr, and vacuum filtering to obtain solution as flos Lonicerae leaf extract; the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1:12;
s4: 2 parts of chitosan is dissolved in 55 parts of 1% acetic acid solution to react for 1.5 hours, 3 parts of succinic anhydride is added, the mixture is uniformly mixed, the pH value of the solution is regulated to 7.2 to react for 6.5 hours, 110 parts of absolute ethyl alcohol is added, and the modified chitosan is obtained after filtration, extraction for 21 hours and drying;
s5: dissolving 16 parts of sodium alginate in 22 parts of deionized water, adding 8 parts of vitamin E and 6 parts of nano calcium carbonate, uniformly mixing, performing ultrasonic reaction for 1h, adding a mixture of 6 parts of liquid paraffin and 3.5 parts of Tween 80, uniformly mixing, slowly adding a mixed solution of 11 parts of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding 110 parts of modified chitosan aqueous solution, uniformly mixing, reacting for 40min, washing with deionized water, centrifuging, freeze-drying, adding 160 parts of deionized water, reacting with 11 parts of 0.1% swelled organic montmorillonite and 0.3 part of titanium dioxide, performing microwave radiation reaction for 2h at a microwave power of 800W at a temperature of 85 ℃, dialyzing, and freeze-drying at a temperature of minus 50 ℃ to obtain the chitosan microspheres;
s6: mixing 3% of 1, 2-propylene glycol, 0.03% of citric acid, 0.2% of ginseng extract, 0.1% of coix seed extract, 0.2% of safflower extract, 2% of chitosan microsphere, 0.2% of honeysuckle leaf extract and 85.78% of deionized water uniformly, adding 0.5% of hydroxyethyl cellulose, heating to 70 ℃, reacting for 1.5h, cooling to room temperature, adding 6% of compound angelica extract and 2% of polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
Example 3: a preparation method of anti-wrinkle whitening essence comprises the following steps:
s1: setting the microwave extraction power to 400W, and extracting 15 parts of white paeony root by using 80 parts of 80% ethanol for 5-10min; setting the microwave extraction power to be 800W, carrying out microwave extraction on 11 parts of angelica and 11 parts of liquorice for 8min by using 200 parts of deionized water, washing, chopping and grinding aloe leaves, soaking in 115 parts of diethyl ether solution for 5.5h, carrying out suction filtration, adding 400 parts of 95% absolute ethyl alcohol, continuously soaking for 24h, carrying out reduced pressure distillation, adsorbing to remove bitter components, concentrating at low temperature, and uniformly mixing with the extracted white paeony root, angelica and liquorice to obtain the composite angelica extract; the mass ratio of the aloe to the white paeony root, the angelica and the liquorice after extraction is 1:1:1:1;
s2: soaking Ginseng radix in 70% absolute ethanol solution, reacting for 0.5 hr, refluxing for 2 hr, filtering, and concentrating the filtrate to obtain Ginseng radix extractive solution; soaking Carthami flos in deionized water, performing ultrasonic reaction for 0.5 hr, filtering, retaining residue, adding deionized water, performing ultrasonic reaction for 0.5 hr, filtering, and collecting filtrate of mobile phone to obtain Carthami flos extract; soaking semen Persicae in deionized water, boiling, reacting for 0.5 hr, and filtering to obtain semen Persicae extract;
s3: screening the honeysuckle leaves by a 500-mesh sieve, adding 60% absolute ethyl alcohol, carrying out water bath reaction at 65 ℃ for 4.8 hours, and carrying out suction filtration to obtain a reserved solution, namely the honeysuckle leaf extract; the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1:12;
s4: dissolving 4 parts of chitosan in 75 parts of 1% acetic acid solution, reacting for 2.5 hours, adding 5 parts of succinic anhydride, uniformly mixing, adjusting the pH value of the solution to 7.5, reacting for 7.5 hours, adding 150 parts of absolute ethyl alcohol, filtering, extracting for 24 hours, and drying to obtain modified chitosan;
s5: dissolving 18 parts of sodium alginate in 28 parts of deionized water, adding 8 parts of vitamin E and 11 parts of nano calcium carbonate, uniformly mixing, performing ultrasonic reaction for 1.5 hours, adding a mixture of 7 parts of liquid paraffin and 4.5 parts of tween 80, uniformly mixing, slowly adding a mixed solution of 16 parts of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding 130 parts of modified chitosan aqueous solution, uniformly mixing, reacting for 50 minutes, washing with deionized water, centrifuging, freeze-drying, adding 170 parts of deionized water, reacting with 18 parts of 0.1% swelling organic montmorillonite and 0.4 part of titanium dioxide, performing microwave radiation reaction for 2 hours at a microwave power of 800W and a microwave radiation temperature of 85 ℃, dialyzing, and freeze-drying at-50 ℃ to obtain chitosan microspheres;
s5: uniformly mixing 4% of 1, 2-propylene glycol, 0.04% of citric acid, 0.2% of ginseng extract, 0.2% of coix seed extract, 0.2% of safflower extract, 4% of chitosan microsphere, 0.4% of honeysuckle leaf extract and 80.36% of deionized water, adding 0.6% of hydroxyethyl cellulose, heating to 75 ℃, reacting for 1.6 hours, cooling to room temperature, adding 8% of compound angelica extract and 2% of polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
Example 4: a preparation method of anti-wrinkle whitening essence comprises the following steps:
s1: setting the microwave extraction power to 400W, and extracting 20 parts of white paeony root for 10min by using 120 parts of 80% ethanol microwave; setting the microwave extraction power to be 800W, carrying out microwave extraction on 12 parts of angelica and 12 parts of liquorice for 10min by using 240 parts of deionized water, washing, chopping and grinding aloe leaves, soaking in 120 parts of diethyl ether solution for 6h, carrying out suction filtration, adding 500 parts of 95% absolute ethyl alcohol, continuously soaking for 25h, carrying out reduced pressure distillation, adsorbing to remove bitter components, concentrating at low temperature, and uniformly mixing with the extracted white paeony root, angelica and liquorice to obtain the composite angelica extract; the mass ratio of the aloe to the white paeony root, the angelica and the liquorice after extraction is 1:1:1:1;
s2: soaking Ginseng radix in 70% absolute ethanol solution, reacting for 0.5 hr, refluxing for 2 hr, filtering, and concentrating the filtrate to obtain Ginseng radix extractive solution; soaking Carthami flos in deionized water, performing ultrasonic reaction for 0.5 hr, filtering, retaining residue, adding deionized water, performing ultrasonic reaction for 0.5 hr, filtering, and collecting filtrate of mobile phone to obtain Carthami flos extract; soaking semen Persicae in deionized water, boiling, reacting for 0.5 hr, and filtering to obtain semen Persicae extract;
s3: sieving flos Lonicerae leaf with-800 mesh sieve, adding 60% absolute ethanol, reacting in water bath at 70deg.C for 5 hr, and vacuum filtering to obtain solution as flos Lonicerae leaf extract; the mass ratio of the honeysuckle leaves to the absolute ethyl alcohol is 1:12;
s4: dissolving 5 parts of chitosan in 80 parts of 1% acetic acid solution, reacting for 3 hours, adding 10 parts of succinic anhydride, uniformly mixing, adjusting the pH value of the solution to 8, reacting for 8 hours, adding 200 parts of absolute ethyl alcohol, filtering, extracting for 25 hours, and drying to obtain modified chitosan;
s5: dissolving 20 parts of sodium alginate in 30 parts of deionized water, adding 10 parts of vitamin E and 12 parts of nano calcium carbonate, uniformly mixing, performing ultrasonic reaction for 2 hours, adding a mixture of 8 parts of liquid paraffin and 5 parts of tween 80, uniformly mixing, slowly adding a mixed solution of 20 parts of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding 150 parts of modified chitosan aqueous solution, uniformly mixing, reacting for 60 minutes, washing with deionized water, centrifuging, freeze-drying, adding 180 parts of deionized water, reacting with 20 parts of 0.1% swelled organic montmorillonite and 0.6 part of titanium dioxide, performing microwave radiation reaction for 2 hours at a microwave power of 800W at a temperature of 85 ℃, dialyzing, and freeze-drying at a temperature of minus 50 ℃ to obtain chitosan microspheres;
s6: uniformly mixing 5% of 1, 2-propylene glycol, 0.05% of citric acid, 0.3% of ginseng extract, 0.3% of coix seed extract, 0.1% of safflower extract, 5% of chitosan microsphere, 0.5% of honeysuckle leaf extract and 74.75% of deionized water, adding 1% of hydroxyethyl cellulose, heating to 80 ℃, reacting for 2 hours, cooling to room temperature, adding 10% of compound angelica extract and 3% of polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
Comparative example
Comparative example 1: in contrast to example 1, vitamin E was coated with sodium alginate alone and prepared in the same manner as in example 1.
Comparative example 2: in contrast to example 1, the same procedure as in example 1 was followed without modification of the chitosan and without addition of titanium dioxide.
Experimental data
Experiment 1:
hydroxyl radical clearance: uniformly mixing 0.5mL of phenanthroline ethanol solution, 1.0mL of PBS with pH of 7.4, 0.5mL of deionized water, 0.5mL of ferric sulfate and 0.5mL of hydrogen peroxide, reacting for 1h in a water bath at 37 ℃, measuring absorbance at 536nm, and marking as A 1 Repeating the operation, replacing hydrogen peroxide with deionized water, measuring absorbance at 536nm, and recording as A 2 Calculating the clearance rate, repeating the operation, replacing deionized water with a sample, and recording the absorbance as A 3 。
After the sample was left for 6 months, it was tested again.
Superoxide anion radical scavenging rate: adding 2.8mL of Tris-HCl buffer solution into the sample, reacting for 0.5h at 25 ℃, continuously adding 0.1mL of pyrogallol at 25 ℃, measuring absorbance at 320nm every 30s, measuring for 5min, plotting, and marking the slope as A 1 The procedure was repeated and the sample was replaced with 0.1mL Tris-HCl buffer with a slope denoted A 2 . After the sample was left for 6 months, it was tested again.
TABLE 1 radical scavenging rates for example 1-example 4, comparative example 1-comparative example 2
Experiment 2:
80 volunteers aged 25-55 years were selected, randomly grouped, and 5 volunteers were each group, and after face washing, the essence was smeared, and after continuous use for 1 month, a melanin measuring instrument was used, at which time the skin melanin content before and after the use of the essence was calculated as an average value.
TABLE 2 melanin detection in examples 1-4, comparative example 1-comparative example 2
| Melanin value before use | Melanin value after use | Difference value | |
| Example 1 | 156 | 95 | 58 |
| Example 2 | 197 | 135 | 62 |
| Example 3 | 162 | 97 | 65 |
| Example 4 | 209 | 154 | 55 |
| Comparative example 1 | 173 | 125 | 48 |
| Comparative example 2 | 198 | 172 | 26 |
Experiment 3: selecting 80 volunteers aged 25-55 years, randomly grouping 5 volunteers in each group, washing face in the morning and evening every day, smearing essence, continuously using for 1 month, evaluating skin feel, and grading speckle fading and wrinkle resisting effects; 5, the method comprises the following steps: the effect is obvious; 4, the following steps: the effect is good; 3, the method comprises the following steps: the effect is general; 2, the method comprises the following steps: the effect is not obvious.
TABLE 3 evaluation of skin feel from example 1 to example 4, comparative example 1 to comparative example 2
| Speckle-reducing agent | Crease-resistant | Evaluation of skin feel | |
| Example 1 | 5 | 4 | Good moisturizing effect and no sensitization |
| Example 2 | 5 | 4 | Good moisturizing effect and no sensitization |
| Example 3 | 5 | 5 | Good moisturizing effect and no sensitization |
| Example 4 | 4 | 4 | Good moisturizing effect and no sensitization |
| Comparative example 1 | 4 | 4 | Good moisturizing effect and no sensitization |
| Comparative example 2 | 4 | 4 | Good moisturizing effect and no sensitization |
Conclusion:
1. the essence prepared by the application has the effects of spot lightening, wrinkle resistance, whitening and oxidation resistance, does not contain irritant substances, can be used by any skin and age group, and does not generate anaphylaxis.
2. Examples 1-4 are compared with comparative example 1, in comparative example 1, only sodium alginate is used for coating vitamin E, so that the scavenging rate of essence to free radicals is better in the early stage, and when the essence is placed for a long time, the scavenging rate of free radicals is reduced, which indicates that leakage occurs when sodium alginate is used for coating vitamin E alone, and the oxidation resistance is reduced.
3. Examples 1-4 are compared with comparative example 2, comparative example 2 did not modify chitosan, nor did titanium dioxide be added, resulting in a small decrease in free radical scavenging rate at the later stage, and the decrease in melanin values was small after use by volunteers, indicating that modification of chitosan, and uv absorption was achieved after titanium dioxide addition, avoiding melanin elevation. The chitosan is modified, so that the solubility of chitosan in aqueous solution can be improved, the coating rate of chitosan microspheres can be improved, and the outflow of vitamin E can be avoided.
Finally, it should be noted that: the foregoing description is only a preferred embodiment of the present application, and the present application is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present application has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application should be included in the protection scope of the present application.
Claims (5)
1. An anti-wrinkle whitening essence is characterized in that: the anti-wrinkle whitening essence comprises the following materials in percentage by mass: 5-10% of composite angelica extract, 0.1-0.5% of ginseng extract, 0.1-0.5% of coix seed extract, 0.1-0.5% of safflower extract, 1-3% of polypeptide, 1-5% of chitosan microsphere, 0.1-0.5% of honeysuckle leaf extract, 0.02-0.05% of citric acid, 0.4-1% of hydroxyethyl cellulose and 2-5% of 1, 2-propylene glycol, and adding deionized water to 100%;
the compound angelica extract is a mixture of white paeony root, angelica, aloe and liquorice extracts; the mass ratio of aloe, white peony root, angelica and liquorice is 1:1:1:1, a step of;
the preparation method of the chitosan microsphere comprises the following steps: dissolving sodium alginate in deionized water, adding vitamin E and nano calcium carbonate, uniformly mixing, performing ultrasonic reaction for 0.5-2h, adding a mixture of liquid paraffin and tween 80, uniformly mixing, slowly adding a mixed solution of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding an aqueous solution of modified chitosan, uniformly mixing, reacting for 30-60min, washing, centrifuging, freeze-drying, dissolving in deionized water, adding organic montmorillonite and titanium dioxide, performing microwave radiation reaction for 2h, dialyzing and freeze-drying to obtain chitosan microspheres;
the preparation method of the modified chitosan comprises the following steps: dissolving chitosan in acetic acid solution, adding succinic anhydride, mixing uniformly, regulating the pH value of the solution to 7-8, reacting for 6-8h, adding absolute ethyl alcohol, filtering, extracting for 20-25h, and drying to obtain the modified chitosan.
2. The method for preparing anti-wrinkle whitening essence according to claim 1, characterized in that: the method comprises the following steps:
s1: extracting radix Paeoniae alba with 80% ethanol under microwave for 5-10min; extracting radix Angelicae sinensis and Glycyrrhrizae radix with deionized water under microwave for 5-10min, cleaning folium Aloe, cutting, grinding, soaking in diethyl ether solution for 4-6 hr, vacuum filtering, adding absolute ethanol, soaking for 22-25 hr, vacuum distilling, adsorbing to remove bitter components, concentrating, and mixing with the extracted radix Paeoniae alba, radix Angelicae sinensis and Glycyrrhrizae radix to obtain compound radix Angelicae sinensis extract;
s2: sieving flos Lonicerae leaf with 200-800 mesh sieve, adding absolute ethanol, performing water bath reaction, and vacuum filtering to obtain solution as flos Lonicerae leaf extract;
s3: the preparation method of the chitosan microsphere comprises the following steps: dissolving sodium alginate in deionized water, adding vitamin E and nano calcium carbonate, uniformly mixing, performing ultrasonic reaction for 0.5-2h, adding a mixture of liquid paraffin and tween 80, uniformly mixing, slowly adding a mixed solution of glacial acetic acid and liquid paraffin, washing, separating and drying to obtain sodium alginate microspheres, adding an aqueous solution of modified chitosan, uniformly mixing, reacting for 30-60min, washing, centrifuging, freeze-drying, dissolving in deionized water, adding organic montmorillonite and titanium dioxide, performing microwave radiation reaction for 2h, dialyzing and freeze-drying to obtain chitosan microspheres;
s4: uniformly mixing 1, 2-propylene glycol, citric acid, ginseng extract, coix seed extract, safflower extract, chitosan microsphere, honeysuckle leaf extract and deionized water, adding hydroxyethyl cellulose, heating to 60-80 ℃, reacting for 1-2h, cooling to room temperature, adding the compound angelica extract and polypeptide, and uniformly mixing to obtain the anti-wrinkle whitening essence.
3. The method for preparing anti-wrinkle whitening essence according to claim 2, which is characterized in that: in the step S2, the content of absolute ethyl alcohol is 60%, the mass ratio of honeysuckle leaves to absolute ethyl alcohol is 1:12, the reaction temperature is 60-70 ℃, and the reaction time is 4-5h.
4. The method for preparing anti-wrinkle whitening essence according to claim 2, which is characterized in that: in the step S1, the microwave extraction power of the white paeony root is 400W; the microwave extraction power of the angelica and the liquorice is 800W.
5. The method for preparing anti-wrinkle whitening essence according to claim 2, which is characterized in that: in step S3, the microwave radiation power was 800W and the radiation temperature was 85 ℃.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103571496A (en) * | 2012-07-18 | 2014-02-12 | 华东理工大学 | Chitosan microsphere with high oxidation resistance and its preparation method |
| CN106265391A (en) * | 2016-11-04 | 2017-01-04 | 王少琼 | A kind of sun-proof moisturizer and preparation method and application |
| CN111297788A (en) * | 2020-04-24 | 2020-06-19 | 广州名门闺秀生物科技有限责任公司 | Whitening and spot-fading essence and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103571496A (en) * | 2012-07-18 | 2014-02-12 | 华东理工大学 | Chitosan microsphere with high oxidation resistance and its preparation method |
| CN106265391A (en) * | 2016-11-04 | 2017-01-04 | 王少琼 | A kind of sun-proof moisturizer and preparation method and application |
| CN111297788A (en) * | 2020-04-24 | 2020-06-19 | 广州名门闺秀生物科技有限责任公司 | Whitening and spot-fading essence and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 壳聚糖微球的制备及其对脂肪酶的固定化研究;刘静娜;黄印强;钱垚;曾永志;;中国酿造(第08期);第109-112页 * |
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