CN114344210A - Biomass disinfection wet tissue containing traditional Chinese medicine components and preparation method thereof - Google Patents
Biomass disinfection wet tissue containing traditional Chinese medicine components and preparation method thereof Download PDFInfo
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Abstract
The invention relates to the technical field of wet tissues and discloses a biomass disinfection wet tissue containing traditional Chinese medicine components, which is extracted once by alcohol extraction and CO2The method comprises the steps of performing supercritical secondary extraction treatment, extracting sophora flavescens, efficiently extracting active substances such as flavone and matrine in the sophora flavescens to obtain sophora flavescens extracts, then extracting Chinese herbal medicines with antibacterial and anti-inflammatory effects such as rheum officinale and oriental wormwood to obtain traditional Chinese medicine disinfection extracts, mixing the sophora flavescens extracts and the traditional Chinese medicine disinfection extracts, adding a biomass antibacterial agent chitosan quaternary ammonium salt with good biocompatibility, compounding to prepare disinfection extract mother liquor, soaking wet tissues, soaking antibacterial and disinfection active ingredients into the wet tissues, and has good inhibition effect on bacteria such as pseudomonas aeruginosa and the like, and no toxic or side effect and irritation on skin.
Description
Technical Field
The invention relates to the technical field of wet tissues, in particular to a biomass disinfection wet tissue containing traditional Chinese medicine components and a preparation method thereof.
Background
The wet tissue can be divided into wet tissue for skin moistening and maintenance and disinfection wet tissue, wherein the disinfection wet tissue has good disinfection and bacteriostasis effects, can be used for disinfecting skin wounds, disinfecting medical instruments and the like, and the nonirritant Chinese herbal medicine extract is applied to the wet tissue to endow the disinfection function of the wet tissue with the development trend of the disinfection wet tissue in recent years, such as the extracts of rhubarb, wormwood and the like, have good bacteriostatic activity.
The sophora flavescens is used as a Chinese herbal medicine, has the effects of clearing heat, drying dampness and killing insects, has important application in the aspects of eczema, skin itch, wound inflammation and the like, contains rich active substances such as sophocarpidine, flavone and the like, has good antibacterial and disinfectant effects, and has no irritation to human bodies and skin, so that the active substances such as sophocarpidine, flavone and the like are efficiently extracted from the sophora flavescens, and then the active substances are applied to wet tissues to endow the wet tissues with good antibacterial and disinfectant properties
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides the biomass disinfectant wet tissue containing the traditional Chinese medicine components and the preparation method thereof, and the biomass disinfectant wet tissue has the advantages of good bacteriostatic effect, strong disinfecting effect and no irritation.
(II) technical scheme
In order to achieve the purpose, the invention provides the following technical scheme: a preparation method of a biomass disinfectant wet tissue containing traditional Chinese medicine components comprises the following steps:
(1) preparing a primary extract of radix sophorae flavescentis: grinding radix Sophorae Flavescentis into powder, adding into ethanol solvent, heating and refluxing, extracting with ethanol, filtering, washing radix Sophorae Flavescentis residue with ethanol, collecting filtrate to obtain radix Sophorae Flavescentis extractive solution, and distilling under reduced pressure to remove solvent to obtain radix Sophorae Flavescentis primary extract.
(2) Preparing a sophora flavescens secondary extract: placing radix Sophorae Flavescentis residue in supercritical extraction kettle, and performing CO extraction2In the supercritical extraction process, the entrainer is ethanol, and then the extraction product is taken out from the extraction kettle to obtain the sophora flavescens secondary extract.
(3) Preparing a sophora flavescens extract: mixing the first extract and the second extract, and aging to obtain the final product.
(4) Preparing a traditional Chinese medicine disinfection extract: grinding radix et rhizoma Rhei, herba Artemisiae Scopariae, cortex Phellodendri, flos Caryophylli and Glycyrrhrizae radix into powder, adding into distilled water and ethanol solvent, heating and refluxing, performing alcohol-water extraction, centrifuging, collecting upper layer liquid, adding ethanol solvent to centrifugally wash lower layer solid, collecting supernatant, and distilling the separated solution under reduced pressure to obtain Chinese medicinal disinfectant extract.
(5) Preparing a disinfectant extract mother liquor: adding radix Sophorae Flavescentis extract, Chinese medicinal antibacterial extract, chitosan quaternary ammonium salt, and aromatic oil into distilled water and ethanol solvent, and dispersing uniformly to obtain disinfectant extract mother liquor.
(6) Preparing the biomass disinfectant wet tissue containing the traditional Chinese medicine components: sterilizing the wet tissue by radiation, and soaking the wet tissue in the mother solution of the sterilization extract for soaking treatment to obtain the biomass sterilization wet tissue containing the traditional Chinese medicine components.
Preferably, the liquid-to-material ratio (g/mL) of the radix sophorae flavescentis and the ethanol in the step (1) is 0.5-20: 150-3000.
Preferably, the alcohol extraction process in the step (1) is carried out at 60-85 ℃ for 2-8 h.
Preferably, the supercritical extraction of CO in the step (2)2The flow is 4-12kg/h, the extraction pressure is 18-25MPa, and the extraction temperature is 40-55 ℃.
Preferably, the liquid-to-material ratio (g/mL) of the rhubarb, the oriental wormwood, the phellodendron bark, the clove, the liquorice, the distilled water and the ethanol in the step (4) is 0.5-5:0.2-1.5:0.4-3:0.15-4:0.1-2: 200-.
Preferably, the alcohol water extraction process in the step (4) is carried out at 85-120 ℃ for 10-20 h.
Preferably, the liquid-material ratio (mL/g) of the distilled water, the ethanol, the sophora flavescens extract, the traditional Chinese medicine antibacterial extract, the chitosan quaternary ammonium salt and the aromatic oil in the step (5) is 500-10000:25-600:0.1-3:0.05-2:4-120: 0.02-0.5.
Preferably, the temperature of the dipping treatment in the step (6) is 20-50 ℃, and the dipping time is 2-6 h.
(III) advantageous technical effects
Compared with the prior art, the invention has the following beneficial technical effects:
the biomass disinfectant wet tissue containing the traditional Chinese medicine components is extracted once by alcohol extraction and CO2Supercritical secondary extraction treatment, namely extracting the radix sophorae flavescentis, efficiently extracting active substances such as flavone, matrine and the like in the radix sophorae flavescentis to obtain a radix sophorae flavescentis extract, then extracting Chinese herbal medicines with antibacterial and anti-inflammatory effects such as rheum officinale, oriental wormwood and the like to obtain a traditional Chinese medicine disinfection extract, mixing the radix sophorae flavescentis extract and the traditional Chinese medicine disinfection extract, adding a biomass antibacterial agent chitosan quaternary ammonium salt with good biocompatibility, compounding to prepare a disinfection extract mother solution, dipping wet tissues, dipping the antibacterial and disinfection active ingredients into the wet tissues, having good inhibition effect on bacteria such as pseudomonas aeruginosa and the like, and having no toxic or side effect and irritation on skin, thereby playing a role in skin wound,and the medical instruments have the functions of sterilization, inflammation diminishing and disinfection.
Detailed Description
To achieve the above object, the present invention provides the following embodiments and examples: a preparation method of a biomass disinfectant wet tissue containing traditional Chinese medicine components comprises the following steps:
(1) preparing a primary extract of radix sophorae flavescentis: grinding radix Sophorae Flavescentis into powder, adding into ethanol solvent at a liquid-to-material ratio (g/mL) of 0.5-20: 150-.
(2) Preparing a sophora flavescens secondary extract: placing radix Sophorae Flavescentis residue in supercritical extraction kettle, and performing CO extraction2Supercritical extraction process, CO2The flow rate is 4-12kg/h, the extraction pressure is 18-25MPa, the extraction temperature is 40-55 ℃, the entrainer is ethanol, and then the extraction product is taken out from the extraction kettle to obtain the sophora flavescens secondary extract.
(3) Preparing a sophora flavescens extract: mixing the first extract and the second extract, and aging to obtain the final product.
(4) Preparing a traditional Chinese medicine disinfection extract: grinding rhubarb, oriental wormwood, golden cypress, clove and liquorice into powder, adding the powder into distilled water and an ethanol solvent, wherein the liquid-material ratio (g/mL) is 0.5-5:0.2-1.5:0.4-3:0.15-4:0.1-2:200 and 5000:35-600 in sequence, heating and refluxing, carrying out an ethanol water extraction process at 85-120 ℃ for 10-20h, carrying out centrifugal separation, taking the upper layer liquid, adding the ethanol solvent to centrifugally wash the lower layer solid, taking the upper layer clear liquid, and distilling the separated solution under reduced pressure to obtain the traditional Chinese medicine disinfection extract.
(5) Preparing a disinfectant extract mother liquor: adding radix Sophorae Flavescentis extract, Chinese medicinal antibacterial extract, chitosan quaternary ammonium salt, and aromatic oil into distilled water and ethanol solvent at a liquid-to-material ratio (mL/g) of 500-10000:25-600:0.1-3:0.05-2:4-120:0.02-0.5, and dispersing uniformly to obtain disinfectant extract mother liquor.
(6) Preparing the biomass disinfectant wet tissue containing the traditional Chinese medicine components: sterilizing the wet tissue by radiation, soaking in the mother solution of the sterilization extract, and soaking at 20-50 deg.C for 2-6h to obtain the biomass sterilization wet tissue containing Chinese medicinal components.
Example 1
(1) Preparing a primary extract of radix sophorae flavescentis: grinding 0.5g radix Sophorae Flavescentis into powder, adding into 150mL ethanol solvent, heating and refluxing, extracting with ethanol at 60 deg.C for 2 hr, filtering, washing radix Sophorae Flavescentis residue with ethanol, collecting filtrate to obtain radix Sophorae Flavescentis extract, and distilling under reduced pressure to remove solvent to obtain radix Sophorae Flavescentis primary extract.
(2) Preparing a sophora flavescens secondary extract: placing radix Sophorae Flavescentis residue in supercritical extraction kettle, and performing CO extraction2Supercritical extraction process, CO2The flow rate is 4kg/h, the extraction pressure is 18MPa, the extraction temperature is 40 ℃, the entrainer is ethanol, and then the extraction product is taken out from the extraction kettle to obtain the sophora flavescens secondary extract.
(3) Preparing a sophora flavescens extract: mixing the first extract and the second extract, and aging to obtain the final product.
(4) Preparing a traditional Chinese medicine disinfection extract: grinding 0.5g of rhubarb, 0.2g of oriental wormwood, 0.4g of phellodendron, 0.15g of clove and 0.1g of liquorice into powder, adding the powder into 200mL of distilled water and 35mL of ethanol solvent, heating and refluxing, carrying out an alcohol-water extraction process at 85 ℃ for 10h, carrying out centrifugal separation, taking the upper layer liquid, adding the ethanol solvent to centrifugally wash the lower layer solid, taking the upper layer clear liquid, and carrying out reduced pressure distillation on the separated solution to obtain the traditional Chinese medicine disinfection extract.
(5) Preparing a disinfectant extract mother liquor: adding 0.1g of radix Sophorae Flavescentis extract, 0.05g of Chinese medicinal antibacterial extract, 4g of chitosan quaternary ammonium salt and 0.02g of aromatic oil into 500mL of distilled water and 25mL of ethanol solvent, and uniformly dispersing to obtain the mother liquor of the disinfectant extract.
(6) Preparing the biomass disinfectant wet tissue containing the traditional Chinese medicine components: sterilizing the wet tissue by radiation, soaking in the mother solution of the sterilization extract, and performing soaking treatment at 20 deg.C for 2h to obtain the biomass sterilization wet tissue containing Chinese medicinal components.
Example 2
(1) Preparing a primary extract of radix sophorae flavescentis: grinding 5g of radix sophorae flavescentis into powder, adding the powder into 1000mL of ethanol solvent, heating and refluxing, performing an alcohol extraction process at 75 ℃ for 4h, filtering, washing radix sophorae flavescentis filter residues by using ethanol, collecting filtrate to obtain radix sophorae flavescentis extract, and then removing the solvent by reduced pressure distillation to obtain the primary radix sophorae flavescentis extract.
(2) Preparing a sophora flavescens secondary extract: placing radix Sophorae Flavescentis residue in supercritical extraction kettle, and performing CO extraction2Supercritical extraction process, CO2The flow rate is 6kg/h, the extraction pressure is 18MPa, the extraction temperature is 50 ℃, the entrainer is ethanol, and then the extraction product is taken out from the extraction kettle to obtain the sophora flavescens secondary extract.
(3) Preparing a sophora flavescens extract: mixing the first extract and the second extract, and aging to obtain the final product.
(4) Preparing a traditional Chinese medicine disinfection extract: grinding 1.5g of rhubarb, 0.6g of oriental wormwood, 1g of golden cypress, 1.5g of clove and 0.5g of liquorice into powder, adding the powder into 1000mL of distilled water and 200mL of ethanol solvent, heating and refluxing, carrying out an alcohol-water extraction process at 100 ℃ for 15h, carrying out centrifugal separation, taking the upper layer liquid, adding the ethanol solvent to carry out centrifugal washing on the lower layer solid, taking the upper layer clear liquid, and carrying out reduced pressure distillation on the separated solution to obtain the traditional Chinese medicine disinfection extract.
(5) Preparing a disinfectant extract mother liquor: adding 0.8g of radix Sophorae Flavescentis extract, 0.1g of Chinese medicinal antibacterial extract, 25g of chitosan quaternary ammonium salt and 0.15g of aromatic oil into 3000mL of distilled water and 200mL of ethanol solvent, and uniformly dispersing to obtain the mother liquor of the disinfectant extract.
(6) Preparing the biomass disinfectant wet tissue containing the traditional Chinese medicine components: sterilizing the wet tissue by radiation, soaking in the mother solution of the sterilization extract, and performing soaking treatment at 30 deg.C for 2h to obtain the biomass sterilization wet tissue containing Chinese medicinal components.
Example 3
(1) Preparing a primary extract of radix sophorae flavescentis: grinding 14g of radix sophorae flavescentis into powder, adding the powder into 2000mL of ethanol solvent, heating and refluxing, performing an alcohol extraction process at 75 ℃ for 6h, filtering, washing radix sophorae flavescentis filter residues with ethanol, collecting filtrate to obtain radix sophorae flavescentis extract, and then removing the solvent through reduced pressure distillation to obtain the primary radix sophorae flavescentis extract.
(2) Preparing a sophora flavescens secondary extract: placing radix Sophorae Flavescentis residue in supercritical extraction kettle, and performing CO extraction2Supercritical extraction process, CO2The flow rate is 8kg/h, the extraction pressure is 20MPa, the extraction temperature is 50 ℃, the entrainer is ethanol, and then the extraction product is taken out from the extraction kettle to obtain the sophora flavescens secondary extract.
(3) Preparing a sophora flavescens extract: mixing the first extract and the second extract, and aging to obtain the final product.
(4) Preparing a traditional Chinese medicine disinfection extract: grinding 3.5g of rhubarb, 1.2g of oriental wormwood, 2g of golden cypress, 3g of clove and 1.5g of liquorice into powder, adding the powder into 3500mL of distilled water and 400mL of ethanol solvent, heating and refluxing, carrying out an alcohol-water extraction process at 100 ℃ for 12h, carrying out centrifugal separation, taking the upper layer liquid, adding the ethanol solvent into the upper layer liquid to carry out centrifugal washing on the lower layer solid, taking the upper layer clear liquid, and carrying out reduced pressure distillation on the separated solution to obtain the traditional Chinese medicine disinfection extract.
(5) Preparing a disinfectant extract mother liquor: adding 2g of radix Sophorae Flavescentis extract, 1.5g of traditional Chinese medicine antibacterial extract, 80g of chitosan quaternary ammonium salt and 0.35g of aromatic oil into 6000mL of distilled water and 350mL of ethanol solvent, and uniformly dispersing to obtain the disinfectant extract mother liquor.
(6) Preparing the biomass disinfectant wet tissue containing the traditional Chinese medicine components: sterilizing the wet tissue by radiation, soaking in the mother solution of the sterilization extract, and performing soaking treatment at 30 deg.C for 4h to obtain the biomass sterilization wet tissue containing Chinese medicinal components.
Example 4
(1) Preparing a primary extract of radix sophorae flavescentis: grinding 20g of radix sophorae flavescentis into powder, adding the powder into 3000mL of ethanol solvent, heating and refluxing, performing an alcohol extraction process at 85 ℃ for 8h, filtering, washing radix sophorae flavescentis filter residues with ethanol, collecting filtrate to obtain radix sophorae flavescentis extract, and then removing the solvent through reduced pressure distillation to obtain the primary radix sophorae flavescentis extract.
(2) Preparing a sophora flavescens secondary extract: placing radix Sophorae Flavescentis residue in supercritical extraction kettle, and performing CO extraction2Supercritical extraction process, CO2The flow is 12kg/h, the extraction pressure is 25MPa, the extraction temperature is 55 ℃, the entrainer is ethanol, and then the extraction product is taken out from the extraction kettleExtracting to obtain radix Sophorae Flavescentis secondary extract.
(3) Preparing a sophora flavescens extract: mixing the first extract and the second extract, and aging to obtain the final product.
(4) Preparing a traditional Chinese medicine disinfection extract: grinding 5g of rheum officinale, 1.5g of oriental wormwood, 3g of golden cypress, 4g of clove and 2g of liquorice into powder, adding the powder into 5000mL of distilled water and 600mL of ethanol solvent, heating and refluxing, carrying out an alcohol-water extraction process at 100 ℃ for 20h, carrying out centrifugal separation, taking upper-layer liquid, adding the ethanol solvent to carry out centrifugal washing on lower-layer solid, taking upper-layer clear liquid, and distilling the separated obtained solution under reduced pressure to obtain the traditional Chinese medicine disinfection extract.
(5) Preparing a disinfectant extract mother liquor: adding 3g of radix Sophorae Flavescentis extract, 2g of traditional Chinese medicine antibacterial extract, 120g of chitosan quaternary ammonium salt and 0.5g of aromatic oil into 10000mL of distilled water and 600mL of ethanol solvent, and uniformly dispersing to obtain the disinfectant extract mother liquor.
(6) Preparing the biomass disinfectant wet tissue containing the traditional Chinese medicine components: sterilizing the wet tissue by radiation, soaking in the mother solution of the sterilization extract, and performing soaking treatment at 50 deg.C for 6h to obtain the biomass sterilization wet tissue containing Chinese medicinal components.
Comparative example 1
(1) Preparation: grinding 2g of rhubarb, 0.6g of oriental wormwood, 2g of golden cypress, 2.5g of clove and 1.2g of liquorice into powder, adding the powder into 3000mL of distilled water and 250mL of ethanol solvent, heating and refluxing, carrying out an alcohol-water extraction process at 100 ℃ for 20h, carrying out centrifugal separation, taking the upper layer liquid, adding the ethanol solvent into the upper layer liquid to carry out centrifugal washing on the lower layer solid, taking the upper layer clear liquid, and carrying out reduced pressure distillation on the separated solution to obtain the traditional Chinese medicine disinfection extract.
(2) Preparing a disinfectant extract mother liquor: adding 1.5g of traditional Chinese medicine antibacterial extract, 80g of chitosan quaternary ammonium salt and 0.3g of aromatic oil into 6000mL of distilled water and 400mL of ethanol solvent, and uniformly dispersing to obtain the disinfectant extract mother liquor.
(3) Preparing the biomass disinfectant wet tissue containing the traditional Chinese medicine components: sterilizing the wet tissue by radiation, soaking in the mother solution of the sterilization extract, and performing soaking treatment at 40 deg.C for 5h to obtain the biomass sterilization wet tissue containing Chinese medicinal components.
And (2) dropwise adding a starch culture medium into a sterile culture dish, dropwise adding pseudomonas aeruginosa suspension liquid, then adding a biomass disinfection wet tissue sheet containing traditional Chinese medicine components as an experimental group, and adding a culture dish without the disinfection wet tissue sheet as a blank group, putting the culture dish of the experimental group and the blank group into a constant-temperature constant-humidity culture box, culturing for 12 hours at the culture temperature of 37 ℃, and testing the antibacterial rate of the disinfection wet tissue by a plate counting method.
Claims (8)
1. A biomass disinfection wet tissue containing traditional Chinese medicine components is characterized in that: the preparation method of the biomass disinfectant wet tissue containing the traditional Chinese medicine components comprises the following steps:
(1) preparing a primary extract of radix sophorae flavescentis: grinding radix Sophorae Flavescentis into powder, adding into ethanol solvent, heating and refluxing, performing ethanol extraction, filtering, washing radix Sophorae Flavescentis residue with ethanol, collecting filtrate to obtain radix Sophorae Flavescentis extractive solution, and distilling under reduced pressure to remove solvent to obtain radix Sophorae Flavescentis primary extract;
(2) preparing a sophora flavescens secondary extract: placing radix Sophorae Flavescentis residue in supercritical extraction kettle, and performing CO extraction2Performing supercritical extraction with ethanol as entrainer, and taking out the extract from the extraction kettle to obtain radix Sophorae Flavescentis secondary extract;
(3) preparing a sophora flavescens extract: mixing radix Sophorae Flavescentis primary extract and radix Sophorae Flavescentis secondary extract, and aging to obtain radix Sophorae Flavescentis extract;
(4) preparing a traditional Chinese medicine disinfection extract: grinding radix et rhizoma Rhei, herba Artemisiae Scopariae, cortex Phellodendri, flos Caryophylli and Glycyrrhrizae radix into powder, adding into distilled water and ethanol solvent, heating and refluxing, performing alcohol-water extraction, centrifuging, collecting upper layer liquid, adding ethanol solvent to centrifugally wash lower layer solid, collecting supernatant, and distilling the separated solution under reduced pressure to obtain Chinese medicinal disinfectant extract;
(5) preparing a disinfectant extract mother liquor: adding radix Sophorae Flavescentis extract, Chinese medicinal antibacterial extract, chitosan quaternary ammonium salt, and aromatic oil into distilled water and ethanol solvent, and dispersing uniformly to obtain disinfectant extract mother liquor;
(6) preparing the biomass disinfectant wet tissue containing the traditional Chinese medicine components: sterilizing the wet tissue by radiation, and soaking the wet tissue in the mother solution of the sterilization extract for soaking treatment to obtain the biomass sterilization wet tissue containing the traditional Chinese medicine components.
2. The biomass disinfectant wet wipe containing traditional Chinese medicine components as claimed in claim 1, is characterized in that: the liquid-material ratio (g/mL) of the radix sophorae flavescentis and the ethanol in the step (1) is 0.5-20: 150-3000.
3. The biomass disinfectant wet wipe containing traditional Chinese medicine components as claimed in claim 1, is characterized in that: the alcohol extraction process in the step (1) is carried out at 60-85 ℃ for 2-8 h.
4. The biomass disinfectant wet wipe containing traditional Chinese medicine components as claimed in claim 1, is characterized in that: the supercritical extraction of CO in the step (2)2The flow is 4-12kg/h, the extraction pressure is 18-25MPa, and the extraction temperature is 40-55 ℃.
5. The biomass disinfectant wet wipe containing traditional Chinese medicine components as claimed in claim 1, is characterized in that: the liquid-material ratio (g/mL) of the rhubarb, the oriental wormwood, the golden cypress, the clove, the liquorice, the distilled water and the ethanol in the step (4) is 0.5-5:0.2-1.5:0.4-3:0.15-4:0.1-2: 200-.
6. The biomass disinfectant wet wipe containing traditional Chinese medicine components as claimed in claim 1, is characterized in that: the alcohol-water extraction process in the step (4) is carried out at 85-120 ℃ for 10-20 h.
7. The biomass disinfectant wet wipe containing traditional Chinese medicine components as claimed in claim 1, is characterized in that: the liquid-material ratio (mL/g) of the distilled water, the ethanol, the sophora flavescens extract, the traditional Chinese medicine antibacterial extract, the chitosan quaternary ammonium salt and the aromatic oil in the step (5) is 500-10000:25-600:0.1-3:0.05-2:4-120: 0.02-0.5.
8. The biomass disinfectant wet wipe containing traditional Chinese medicine components as claimed in claim 1, is characterized in that: the temperature of the dipping treatment in the step (6) is 20-50 ℃, and the dipping time is 2-6 h.
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Citations (5)
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|---|---|---|---|---|
| CN101084989A (en) * | 2007-07-11 | 2007-12-12 | 石任兵 | Method for preparing general flavone and total alkaloid of sophora flavescens simultaneously |
| CN104490674A (en) * | 2014-12-08 | 2015-04-08 | 成都顺发消洗科技有限公司 | Disinfectant wet wipe |
| CN110302302A (en) * | 2019-08-06 | 2019-10-08 | 阿谷巴科技（唐山）有限公司 | A kind of antibacterial liquid formulations |
| CN112842959A (en) * | 2021-01-30 | 2021-05-28 | 亿茂环境科技股份有限公司 | Formula and manufacturing process of traditional Chinese medicine and western medicine synthesized disinfection wet tissue |
| CN113679648A (en) * | 2021-09-02 | 2021-11-23 | 衢州市衢江区廿里镇养和残疾人之家 | Wet tissue with sterilization and inflammation diminishing functions and preparation method thereof |
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2021
- 2021-12-25 CN CN202111603564.0A patent/CN114344210A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101084989A (en) * | 2007-07-11 | 2007-12-12 | 石任兵 | Method for preparing general flavone and total alkaloid of sophora flavescens simultaneously |
| CN104490674A (en) * | 2014-12-08 | 2015-04-08 | 成都顺发消洗科技有限公司 | Disinfectant wet wipe |
| CN110302302A (en) * | 2019-08-06 | 2019-10-08 | 阿谷巴科技（唐山）有限公司 | A kind of antibacterial liquid formulations |
| CN112842959A (en) * | 2021-01-30 | 2021-05-28 | 亿茂环境科技股份有限公司 | Formula and manufacturing process of traditional Chinese medicine and western medicine synthesized disinfection wet tissue |
| CN113679648A (en) * | 2021-09-02 | 2021-11-23 | 衢州市衢江区廿里镇养和残疾人之家 | Wet tissue with sterilization and inflammation diminishing functions and preparation method thereof |
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