CN114306200B - Anti-aging repairing composition and application thereof - Google Patents

Abstract

The invention relates to IPC A61K 8/00, in particular to an anti-aging repair composition and application thereof. The raw materials comprise, by weight: 0.5-4 parts of active liposome, 0.05-1 part of phytoglycogen, 0.5-3 parts of synbiotics and 0.1-5 parts of plantago longifolia extract. The vitamin A derivatives and lecithin in two forms form a transporter, dehydrated glycogen and synbiotics are combined, and the plantago longifolia extract with pleasant sense organ anti-aging special effects is combined, so that an anti-aging synergistic effect is provided for skin, a microbial barrier is enhanced, the skin regeneration and repair capability is optimized, the skin micro-fluctuation state is improved, and the skin is smooth and fine. The cream is applied to repairing milk, effectively improves the sensitive state of skin, relieves the skin problems such as acne, redness, inflammation and the like, and meanwhile, the product is light in texture, has good uniformity and spreadability, and has good sensory experience.

Description

Anti-aging repairing composition and application thereof

Technical Field

The invention relates to IPC A61K 8/00, in particular to an anti-aging repair composition and application thereof.

Background

Aging is a necessary trend of the change of organism functions with age; the deterioration of the ecological environment and the acceleration of the life rhythm at the present stage are also silently accelerating the process; tightening, anti-aging, energizing, activating and brightening skin color becomes the efficacy enhancing direction of the skin care product. Retinol can promote the normal differentiation of skin keratinocytes, but the retinol has the problems of large irritation, poor stability and poor formula compatibility in the actual application process; to increase the bioavailability of retinol, liposome encapsulation techniques are commonly used to process retinol. However, the traditional liposome has the problems of poor stability, limited loading capacity, poor transmission capacity, difficult use and the like. Meanwhile, the microecological balance of the skin gradually appears on the importance of the skin, but the stable regulation and control of the microecological balance of the skin still cannot be realized. Based on the method, the defects of the traditional coating technology are overcome, the bioavailability of active substances is improved, a skin microorganism barrier is constructed, and the skin feel of the skin care product is optimized; the skin care product has the advantages of being strong in anti-aging and repairing effects, capable of effectively improving the sensitive state of skin, smoothing and refining the skin, reducing textures, relieving the comprehensive problems of acnes, acne marks and other skin, green and environment-friendly in raw materials, simple and convenient in process, fresh and light in skin feel, and the like, and is a research direction in the field.

Disclosure of Invention

The invention solves the problems of low bioavailability, poor stability and the like of active ingredients of skin care products in the prior art by providing the anti-aging repairing composition. The invention provides a composition for solving facial anti-aging at multiple angles by combining a microecological efficacy raw material and a Lipolink wrapping double A technology, which overcomes the irritation of vitamin A and derivatives thereof, combines the microecological efficacy raw material and a novel pleasant anti-aging mechanism, and realizes the establishment of a microbial barrier of skin, thereby endowing a skin care product with multiple effects of fine and smooth skin, improving skin sensitivity, reducing skin inflammation, reducing skin texture and the like.

The invention provides an anti-aging repair composition, which comprises the following raw materials in parts by weight: 0.5-4 parts of active liposome, 0.05-1 part of phytoglycogen, 0.5-3 parts of synbiotics and 0.5-5.0 parts of plantago longifolia extract.

In some preferred embodiments, the weight ratio of active liposome, phytoglycogen, synbiotic, plantago longifolia extract in the anti-aging composition is (1-2): (0.1-0.4): (0.5-1.5): (2-4).

In some preferred embodiments, the active liposome is a lecithin encapsulated vitamin and derivatives thereof using LipoLink technology.

In some preferred embodiments, the vitamins and derivatives thereof include one or more combinations of retinoic acid, retinaldehyde, retinol palmitate, retinol acetate.

In order to accelerate the production of new collagen by skin cells and to promote the autonomous repair and protection of the skin barrier, in some preferred embodiments the vitamins and their derivatives are retinol and retinol palmitate, the weight ratio of retinol to retinol palmitate being (1-5): (2-14).

The retinol has the problems of large irritation, poor stability and poor formula compatibility in the actual application process; to increase the bioavailability of retinol, liposome encapsulation techniques are commonly used to process retinol. However, the traditional liposome has the problems of poor stability, limited loading capacity, poor transmission capacity, difficult use and the like. The invention adopts the lipoLink technology to carry out brand new processing on the retinol, so that the active ingredients are effectively bound on the phospholipid membrane of the double-layer liposome, the formed compound can penetrate the skin at the highest speed, and the multi-layer system has the following advantages: (1) Food-grade phospholipids are adopted to simultaneously wrap 3.08 percent of retinol and 9.80 percent of retinol palmitate, so that the skin and eyes are not irritated; (2) The stability is high, so that the active substances and the double-layer liposome phospholipid membrane are tightly combined through Van der Waals force to form a multilayer stable transporter, and the wrapped retinol can resist oxidation and high temperature; (3) The preparation method is easy to use, the LipoLink technology forms a dehydrated product, liposome microcapsules are formed spontaneously immediately after water is added, the compatibility with a formula is strong, and the penetration and transmission capacity of retinol and derivatives thereof on the surface layer of skin are greatly improved; (4) Double wrapping provides multiple effects for skin, on one hand, can effectively regulate the auxiliary factors of epithelial cell differentiation and growth, promote the skin elastin level, promote the formation of elastic fiber network on the skin surface layer, and optimize the structural integrity and barrier effect of epithelial tissues; on the other hand, the skin-care composition can repair damaged cells, help skin resist free radical action and repair skin photodamage.

Preferably, the active liposome is lecithin-coated retinol and retinol palmitate, and the weight ratio of the retinol to the retinol palmitate is 3.08:9.80; the active liposome has the commodity name of active retinol, the specification of 1kg and the performance of wrinkle reduction and aging resistance; the active retinol is sourced from the company manting (Guangzhou) trade limited.

In some preferred embodiments, the phytoglycogen is extracted from at least one of corn, barley, oat, buckwheat, sorghum, rye, fava bean, mung bean, pea, banana, gingko, chestnut, sea buckthorn.

Further preferably, the phytoglycogen is extracted from corn; still more preferably, the corn is a non-transgenic sweet corn.

In some preferred embodiments, the extraction method is specifically milling, stirring, centrifuging, water extraction, filtering, sterilizing the filtrate, and drying to obtain high purity phytoglycogen.

The invention combines sustainable raw materials with a green water extraction process, and can obtain nanoscale glycogen particles with uniform size, unchanged glycogen molecules and extremely low impurity content without the help of chemicals, enzymes or harsh conditions. The large molecular branched glycogen is taken as an energy storage unit, so that the growth of cells under metabolic pressure can be promoted, the particle size of the obtained phytoglycogen is smaller than that of skin cell pores, the phytoglycogen can be quickly absorbed by skin and smoothly permeate into the deep of skin dermis cells, on one hand, the phytoglycogen is metabolized to provide energy for the growth of the cells for monosaccharide, on the other hand, a water-retaining structure is provided to provide a long-acting moisturizing effect, so that the smoothness of the skin is effectively improved, the speckles are reduced, and the skin relaxation is inhibited. Meanwhile, the glycogen dendritic structure can efficiently adsorb and load active ingredients, and carry the active ingredients to deep tissues of skin, so that the skin state is fundamentally improved, physiological effects in the skin aging process are inhibited, and the skin tolerance is improved. Meanwhile, the phytoglycogen disclosed by the invention is added into the composition, so that the raw material system can be endowed with better uniformity, comfortable sensory experience can be provided for the skin, the product is endowed with higher spreadability when in use, the phytoglycogen is rapidly absorbed by the skin, the skin surface after absorption is smooth and soft, and the residual feeling is low and is not greasy.

In some preferred embodiments, the centrifugation is preferably performed sequentially through a decanter centrifuge and a disk centrifuge.

Preferably, the phytoglycogen has the commodity name of sugar beauty, the English name of GLYCOPURE, the specification of 1kg, and the performance of film forming and moisture retention, energy supply for skin cells, whitening and antioxidation; the sugar beauty is derived from manting trade limited company.

In some preferred embodiments, the synbiotics include prebiotics and probiotics; the prebiotics are alpha-glucan oligosaccharides and/or beta-fructooligosaccharides.

Further preferably, the prebiotics are α -glucan oligosaccharides and β -fructooligosaccharides; the weight ratio of the alpha-glucan oligosaccharide to the beta-fructooligosaccharide is (2-6): 1, most preferably 3.5:1.

preferably, the source of the alpha-glucan oligosaccharides is obtained by performing enzyme-catalyzed synthesis on a plant substrate.

Preferably, the beta-fructooligosaccharides are preferably obtained from cold-pressed juice of the root of saussurea involucrata.

In some preferred embodiments, the probiotic comprises lactobacillus and/or bifidobacterium.

In some preferred embodiments, the lactobacillus comprises at least one of lactobacillus casei, lactobacillus acidophilus, lactobacillus rhamnosus, lactobacillus gasseri.

In order to balance the ecological flora inside the skin and strengthen the microbial defense barrier, preferably the synbiotics are a mixture of alpha-glucan oligosaccharides, beta-fructooligosaccharides, lactobacillus casei and lactobacillus acidophilus. The beta-fructo-oligosaccharide is derived from the root juice of the purple sweet potato (POLYMNIA SONCHIFOLIA).

The addition of probiotics can balance the microbial flora of the skin, increase bacterial diversity and strengthen the microbial barrier; the prebiotics are derived from natural carbohydrates, which allow the host microorganism to selectively utilize healthy substrates, stimulating the growth and metabolic activity of non-pathogenic bacteria. The invention combines the advantages of prebiotics and probiotics, and adopts skin probiotics to create a solution which has positive effects on skin microbiota, and rebalance the microbial ecosystem of sensitive muscles. Research data indicate that synbiotics have the following advantages: (1) The bacterial diversity can be increased, and the bacterial biodiversity is obviously increased on the scale of 15 days; (2) Promoting the biological assimilation of saprophytic bacteria, supplying carbon source for skin symbiotic microorganisms, and keeping the balance of skin microorganism flora; (3) Activating the expression of beta-defensin 2 in human body, remarkably enhancing the expression of hBD3 and enhancing the natural defensin ability of skin; (4) The skin micro-relief is improved, the skin tissue structure is optimized, the skin uniformity is improved, the skin texture with disordered texture gradually tends to be regular and compact, the average depth of the micro-relief is reduced, the effect of improving the skin micro-relief state and reducing the surface complexity is achieved, and the skin tends to be smooth and stretched and is smooth and glossy.

Preferably, the synbiotics are named as skin probiotics, the English name is ECOSKIN, the specification is 5kg, the performance is to strengthen the microbial barrier, improve the skin micro-fluctuation and improve the skin luster; skin probiotics originate from the company manting trade limited (guangzhou).

In some preferred embodiments, the plantain extract is specifically a plant polysaccharide extracted from plantain seed. The plantain seeds are rich in mucus, and the structure of the plantain seeds contains polysaccharide with strong water retention capacity, so that a large amount of water is retained, and the plantain seeds are conveniently immersed into skin through bionic action; the multi-branched carbohydrate in the polysaccharide is in a reticular structure, so that the polysaccharide forms hydrophilic colloid, has the characteristics of relieving and calming, has unique texture when in use, and protects the structural integrity of skin. The invention discovers in the research process that the addition of the plantain extract into the anti-aging repair composition has the following advantages: (1) Recombinant and plump skin, enhancing repair of deep skin structures and expression of decorin; (2) The plantago longifolia extract can not only regenerate the natural soothing ability of the skin and keep the skin in a more sedative and calm state, but also activate the release of dopamine and stimulate a happy mechanism; (3) Providing a unique sensory experience to the skin, imparting excellent spreadability and envelope effect to the composition, enhancing the soft feel of the formulation; (4) The skin is young, the generation of wrinkles is reduced, the facial outline can be remodeled after the skin is adhered to the skin, the harmony and the plumpness of the face are restored, and the premature senility of the skin is effectively prevented.

Preferably, the plantago longifolia extract is a three-dimensional skin-care agent, the English name is 3DERMILYN, the specification is 5kg, the performance is active anti-aging based on biological sense direction, and anti-aging care for providing prevention and curative effects for skin is provided; three-dimensional skin-soothing agents are derived from the company manting (Guangzhou) trade limited.

The second aspect of the invention provides the application of the anti-aging repairing composition to the essence milk, wherein the anti-aging repairing composition accounts for 0.1-16% of the total mass of the essence milk.

In some preferred embodiments, the raw materials of the essence milk comprise, by weight:

phase A: water is added for the rest, chelating agent is 0.01-0.1%, humectant is 1-10%, solvent is 1-10%, thickening stabilizer is 0.2-5%, and first emulsifier is 0.1-5%;

and B phase: 0.1-4% of a second emulsifier, 3-12% of a first emollient;

and C phase: 5.2% of anti-aging repair composition, 1-5% of second emollient, 0.1-2% of antioxidant, 0.1-4% of solvent, 0.01-1% of biological sugar gum, 0.1-3% of ecological nutrient solution and 0.1-1% of preservative.

In some preferred embodiments, the C phase is specifically divided into C1, C2, C3 components.

The C1 component is an active liposome in an emollient, an antioxidant and an anti-aging repair composition.

The C2 component is solvent, biological sugar gum, ecological nutrient solution, phytoglycogen in the anti-aging repairing composition, synbiotics and herba plantaginis extract.

The C3 component is a preservative.

In some preferred embodiments, the first emollient comprises one or more of white pool flower seed oil, squalane, ethylhexyl hydrogenated olive oleate, hydrogenated olive oil unsaponifiables, olive oil, safflower seed oil, leaf soybean oil, jojoba oil, almond oil, shea butter, rose hip oil, carmine oil, polydimethylsiloxane, cyclodimethicone, trisiloxane, caprylic capric triglyceride, isononyl isononanoate, hydrogenated polydecene, isododecane, pentaerythritol tetra (ethylhexanoate), hydrogenated lecithin.

In some preferred embodiments, the humectant comprises one or more combinations of lactobacillus/soybean fermentation product extract, polyols, allantoin, hydrolyzed hyaluronic acid, glycogen, glyceroglycosides, ginkgo mistletoe leaf extract, biogel-1, sodium hyaluronate, lactobacillus/soybean milk fermentation product filtrate, lalang grass rhizome extract, trehalose.

The polyols include, but are not limited to, glycerol, methylpropanediol, propanediol, butanediol, pentanediol, hexanediol, and the like.

In some preferred embodiments, the thickening stabilizer may be selected from synthetic polymeric thickening stabilizers such as carbomers (polyacrylic acid) and sodium salts, acrylate/C10-30 alkyl acrylate cross-linked polymers, ammonium acryloyldimethyl taurate/VP copolymers, hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymers, and the like; natural gums and modifications thereof may be selected, such as xanthan gum, guar gum, hydroxypropyl guar gum, sclerotium gum, and the like; cellulose, such as cellulose, ethylcellulose, hydroxyethylcellulose, cellulose gum, methylcellulose, hydroxypropyl methylcellulose, carboxymethyl cellulose, and the like, may be selected.

In some preferred embodiments, the first and second emulsifiers each comprise one or more of polyglycerol-6 tristearate, inulin lauryl carbamate, isotridecyl isononanoate, glycerol stearate, polyglycerol-3 methyl glucose distearate, C12-18 alkyl glucoside, polyacrylate, C18-21 alkane, hydrogenated polydecene, ethylhexyl stearate, cetostearyl alcohol, C13-14 isoparaffin, mineral oil, hydrogenated lecithin, dioctyl carbonate, trideceth-6, sorbitan stearate, polyglycerol-10 stearate, ammonium acryloyldimethyl taurate/VP copolymer, stearic acid.

In some preferred embodiments, the process for preparing the essence emulsion comprises the following steps:

s1, adding the phase A raw materials (except water) into water one by one, stirring and mixing uniformly, and heating to 85 ℃ for standby;

s2, mixing the raw materials of the phase B, and heating to 85 ℃ for standby;

s3, uniformly mixing the C1 and C2 phase raw materials respectively for standby;

s4, adding the B phase raw material into the A phase raw material for emulsification, and homogenizing for 2-5 minutes under the condition of 8000-10000 RPM;

s5, stirring and cooling to 35-42 ℃, adding a C1 phase, and homogenizing for 0.5-2.0 minutes at 6000-8000 RPM;

s6, adding the C2 phase and the C3 phase, and uniformly stirring to obtain a finished product.

The beneficial effects are that:

the anti-aging repair composition and the application thereof provided by the invention have the following advantages:

(1) The vitamin A derivatives with two forms and lecithin are adopted to act to form a transporter, and the transporter is combined with dehydrated glycogen extracted from non-transgenic sweet corn and specific synbiotics composed of prebiotics and probiotics, and is matched with the plantago longifolia extract with a pleasant sensory anti-aging special effect, so that the problems that the existing vitamin A derivatives are poor in stability, large in irritation, low in liposome encapsulation degree, difficult to use as active ingredients for skin and the like are solved, synergism is provided for the skin, microbial barriers are enhanced, metabolic activity of skin fibroblasts is improved, skin regeneration and repair capability is optimized, skin is protected against ultraviolet injury, skin permeability and elastin level are improved, skin micro-fluctuation state is improved, facial contours are remodeled, facial harmony and plumpness are restored, and the skin is smooth and compact and is full of gloss.

(2) The anti-aging repairing composition is applied to skin care products such as essence emulsion, effectively resists aging through the synergistic effect of raw materials, effectively improves the sensitive state of skin, relieves the skin problems such as acne, redness, inflammation and the like, meanwhile, the product is light in texture, has good uniformity and spreadability, is mild and has no stimulation, the skin feel is obviously improved, and excellent sensory experience is created while the anti-aging repairing effect is optimized.

Drawings

Fig. 1. ANTERA3D imaging of volunteers after use of example 2;

FIG. 2. Variation of heme concentration in volunteers after use of example 2;

fig. 3. Changes in facial depression volume after volunteers use example 2;

FIG. 4. Skin feel test results after skin feel panelists used examples 2 and 6;

FIG. 5 is a graph showing the results of the sample at 48℃on day 30 (examples 2,3,4,5,6, in order from left to right);

FIG. 6 is a graph of the results of the samples on day 30 when left under UV conditions (examples 2,3,4,5,6, in order from left to right);

FIG. 7 is a graph of the results of the samples on day 30 when placed at 25 ℃ (examples 2,3,4,5,6, in order from left to right);

FIG. 8 is a graph showing the results of the sample at 5℃on day 30 (examples 2,3,4,5,6, in order from left to right).

Detailed Description

Example 1.

The embodiment provides an anti-aging repair composition, which comprises the following raw materials in parts by weight:

raw materials	Parts by weight (parts)
		Active liposome	1.5
Phytoglycogen	0.2
		Synbiotic element	1.0
Plantago longifolia extract	3.0

The active liposome is lecithin-coated vitamin and derivatives thereof.

The vitamins and the derivatives thereof are retinol palmitate, and the weight ratio of the retinol palmitate to the retinol palmitate is 3.08:9.80.

the active liposome has the commodity name of active retinol, the specification of 1kg and the performance of wrinkle reduction and aging resistance; the active retinol is sourced from the company manting (Guangzhou) trade limited.

The phytoglycogen is extracted from non-transgenic sweet corn.

The extraction method comprises the steps of grinding non-transgenic sweet corn, stirring, centrifuging, extracting with water, filtering, sterilizing the filtrate, and drying to obtain high-purity phytoglycogen.

The centrifugation is preferably performed sequentially through a decanter centrifuge and a disk centrifuge.

The phytoglycogen has the commodity name of sugar beauty, the English name of GLYCOPURE, the specification of 1kg, and the performance of film forming and moisture preservation, energy supply for skin cells, whitening and antioxidation; the sugar beauty is derived from manting trade limited company.

The synbiotics comprise prebiotics and probiotics;

the prebiotics are alpha-glucan oligosaccharides and beta-fructooligosaccharides; the weight ratio of the alpha-glucan oligosaccharide to the beta-fructooligosaccharide is 3.5:1.

the source of the alpha-glucan oligosaccharide is obtained by performing enzyme catalysis synthesis on a plant matrix.

The beta-fructo-oligosaccharide is preferably obtained by cold-pressing juice of yacon root of saussurea involucrata.

The probiotics are lactobacillus, and the lactobacillus is lactobacillus casei and lactobacillus acidophilus.

The synbiotics are named as skin probiotics, the English name is ECOSKIN, the specification is 5kg, the performance is to strengthen the microbial barrier, improve the skin micro-fluctuation and improve the skin luster; skin probiotics originate from the company manting trade limited (guangzhou).

The product name of the plantago longifolia extract is three-dimensional skin-happing agent, the English name is 3DERMILYN, the specification is 5kg, the performance is active anti-aging based on biological sense orientation, and anti-aging nursing for providing prevention and curative effects for skin is provided; three-dimensional skin-soothing agents are derived from the company manting (Guangzhou) trade limited.

Example 2.

This example provides the use of the anti-aging treatment composition of example 1, applied to an essence emulsion comprising:

the chelating agent is disodium EDTA and is derived from BASF (Basoff).

The humectant is methyl propylene glycol and sodium hyaluronate, and the weight ratio of the methyl propylene glycol to the sodium hyaluronate is 3:0.05.

the average molecular weight of the sodium hyaluronate is 20-30 ten thousand, and the sodium hyaluronate is derived from bloom (Hua Xi organisms).

The first emulsifier is a mixture of glycerin and inulin lauryl carbamate, and is derived from SETHIC (mantel), and is commercially available under the trade name of emulsifier SL1.

The second emulsifier is mixture of cetostearyl alcohol, glyceryl stearate, stearic acid, hydrogenated lecithin, and polyglyceryl-3 methyl glucose distearate, and is commercially available from Xianting trade company, guangzhou.

The thickening stabilizer is an ammonium acryloyldimethyl taurate/VP copolymer, and is derived from CLARIANT (Craien), and the product name is Aristoflex AVC.

The emollient comprises white pool (LIMNANTHES ALBA) seed oil, hydrogenated olive oil derivative, squalane; the weight ratio of the white pool flower (LIMNANTHES ALBA) seed oil to the hydrogenated olive oil derivative to the squalane is 3:3:2.

the white pond flower (LIMNANTHES ALBA) seed oil is derived from SETHIC (manting), and is commercially available under the name of pond flower seed oil.

The hydrogenated olive oil derivative is derived from the company of the trade limited of manting (Guangzhou), and has the trade name of excellent elemene.

The squalane is derived from the company of Xianting trade, guangzhou, and has the trade name of green olive squalane.

The emollient is caprylic/capric triglyceride, derived from Sasol (Sha Suo), under the trade name 812N-GTCC.

The antioxidant comprises tocopheryl acetate and diethyl hexyl butylidenyl malonate, and the weight ratio of the tocopheryl acetate to the diethyl hexyl butylidenyl malonate is 5:3.

the diethylhexyl butylidenimate is derived from Merck under the trade name OXYNEX ST LIQUID.

The solvent is methyl propylene glycol, which is derived from the company OF manting trade, guangzhou, and has the trade name riddle OF.

The biological gum is specifically maltodextrin loaded biological gum-1, and is derived from manting trade company, guangzhou, and the commercial name is biological polysaccharide gum powder.

The ecological nutrient solution is specifically a mixture of inulin, water and alpha-glucan oligosaccharides, and is derived from Axialys (European patent Li Si) and has the trade name of ecological nutrient solution.

The preservative is specifically 1, 2-hexanediol, which is derived from SYMRISE (De. TM.) and is commercially available under the name Hydrolite 6.

The preparation method of the essence milk comprises the following steps:

s1, adding the phase A raw materials (except water) into water one by one, stirring and mixing uniformly, and heating to 85 ℃ for standby;

s2, mixing the raw materials of the phase B, and heating to 85 ℃ for standby;

s3, uniformly mixing the C1 and C2 phase raw materials respectively for standby;

s4, adding the B-phase raw material into the A-phase raw material for emulsification, and homogenizing for 3 minutes under 9000RPM (revolutions per minute);

s5, stirring and cooling to 40 ℃, adding the C1 phase, and homogenizing for 1 minute at 7000 RPM;

s6, adding the C2 phase and the C3 phase, and uniformly stirring to obtain a finished product.

Example 3.

The present example provides an application of an anti-aging composition, wherein the anti-aging composition provided in example 1 is applied to essence emulsion, and the specific embodiment is the same as example 2; the difference is that the raw materials of the essence milk comprise:

example 4.

The present example provides an application of an anti-aging composition, wherein the anti-aging composition provided in example 1 is applied to essence emulsion, and the specific embodiment is the same as example 2; the difference is that the raw materials of the anti-aging repair composition comprise:

raw materials	Parts by weight (parts)
		Active liposome	5
Phytoglycogen	0.2
		Synbiotic element	1
Plantago longifolia extract	3

And the addition amount of the active liposome in the essence emulsion is 5%.

Example 5.

The present example provides an application of an anti-aging composition, wherein the anti-aging composition provided in example 1 is applied to essence emulsion, and the specific embodiment is the same as example 2; the difference is that,

raw materials	Parts by weight (parts)
		Active liposome	1.5
Phytoglycogen	0.2
		Synbiotic element	5
Plantago longifolia extract	3

And the addition amount of the synbiotics in the essence emulsion is 5%.

Example 6.

The present example provides an application of an anti-aging composition, wherein the anti-aging composition provided in example 1 is applied to essence emulsion, and the specific embodiment is the same as example 2; the difference is that the first emulsifier is not added into the essence milk.

Experimental variables for the specific embodiments of the examples are shown in the following table:

performance testing

1. Skin repair effect:

efficacy test: 7 volunteers with sensitive skin condition, repeated acne growth on the face for 1-2 months and rough skin were screened. Volunteers used the cream concentrate provided in example 2 continuously for 28 days, with a frequency of 1 each of the morning and evening daily. The facial status was tested on days 0,7, 21, 28, with a graphical representation of the effect of one female volunteer test as shown in fig. 1 and the results of the 7 volunteers test as shown in fig. 2-3.

Preparation: cleaning the face before each measurement, gently wiping the face with a face towel, and testing the skin of the face by adopting ANTRA 3D;

the using method comprises the following steps: test tracking is to take a proper amount of essence emulsion provided in example 2 at night daily, gently apply the essence emulsion to the eyes and face, massage the eyes and face until absorption, and test the essence emulsion before use (D0), on day 7 (D7), on day 21 (D21) and on day 28 (D28) respectively.

The testing method comprises the following steps: using an ANTERA3D imaging method, measuring the facial area of the test subject by using D0, D7, D21 and D28, and particularly measuring the heme concentration and the volume of a facial depression area of the facial pop area; the change in heme concentration and the volume of the recessed area were compared. The results of the ANTERA3D imaging of one of the volunteers with significant changes are shown in fig. 1. As can be seen from fig. 1 to 3, the effects of acne removal and relief on the faces of volunteers are obvious after 7 days, the skin pits are obviously improved after 21 days, and the skin heme concentration and the facial skin pit volume are obviously reduced after 28 days.

2. Testing stability;

the essence milk provided in example 2,3,3,5,6 was tested for stability under the following conditions, and the results are recorded in table 1.

Test conditions: the sample is put into constant temperature equipment with the temperature of 48 ℃, 25 ℃,5 ℃ and 18 ℃ below zero and UV irradiation for stability test, and the sample is taken out at days 0, 1,7, 14, 21 and 30 respectively to observe whether the appearance of the product has obvious abnormal change phenomena such as color change, layering, precipitation and precipitation.

3. Skin feel test:

the cream provided in example 2 and example 6 was used for skin feel testing. Specifically, 5 professional skin sensing panelists are invited to carry out skin feeling pairwise comparison on the samples of the example 2 and the example 6, index scoring evaluation is carried out, 5-minute system is adopted, the unit score of the evaluation is 0.5, and the larger the score is, the more obvious the index feature is; the experimental evaluation environment temperature is: 20-22 ℃; the relative humidity of the environment is 40% -60%; the scoring results are recorded in table 2.

4. Performance test results:

TABLE 1 stability test results

Based on the stability tracking table and sample appearance results described above:

appearance stability shows: examples 2,3,6 showed little difference in color change for 3 days at each temperature condition; whereas examples 4 and 5 are more color-differentiated;

emulsion stability: examples 2,3,4 and 5 were normal in emulsion stability, example 6 showed a phenomenon of oil-bleaching when the material was observed, and a phenomenon of micro-layering was observed at 48℃for 30 days, and the emulsion stability was greatly different from example 2.

TABLE 2 skin feel test results

TABLE 3 sensory evaluation skin feel index description

Summarizing: example 6 comparative example 2, the skin feel of the essence product after the addition of the first emulsifier reduced the oily feel upon application and the heavy feel after application; the sample of example 6 has better glossiness, faster absorption when being smeared, and fresh and tender skin after being smeared.

Claims (3)

1. The anti-aging repair essence emulsion is characterized by comprising the following raw materials in percentage by weight:

phase A: water is added for the rest, chelating agent is 0.01-0.1%, humectant is 1-10%, water is 1-10%, thickening stabilizer is 0.2-5%, and first emulsifier is 0.1-5%;

and B phase: 0.1-4% of a second emulsifier, 3-12% of a first emollient;

and C phase: 5.2% of anti-aging repair composition, 1-5% of second emollient, 0.1-2% of antioxidant, 0.1-4% of methyl propylene glycol, 0.01-1% of biological sugar gum, 0.1-3% of ecological nutrient solution and 0.1-1% of polyalcohol preservative;

the anti-aging repairing composition comprises the following raw materials in parts by weight: 0.5-4 parts of active liposome, 0.05-1 part of phytoglycogen, 0.5-3 parts of synbiotics and 0.5-5.0 parts of plantago longifolia extract; the active liposome is lecithin-coated vitamin and derivatives thereof; the vitamins and their derivatives include one or more of retinoic acid, retinaldehyde, retinol palmitate, retinol acetate; the synbiotics comprise prebiotics and probiotics; the prebiotics are alpha-glucan oligosaccharides and/or beta-fructooligosaccharides; the probiotics comprise lactobacillus and/or bifidobacterium;

the first emulsifier is a mixture of glycerin and inulin lauryl carbamate; the second emulsifier is a mixture of cetostearyl alcohol, glyceryl stearate, stearic acid, hydrogenated lecithin, polyglycerol-3 methyl glucose distearate; the thickening stabilizer is an ammonium acryloyldimethyl taurate/VP copolymer;

the first emollient comprises white pool seed oil, hydrogenated olive oil derivative, squalane; the second emollient is caprylic/capric triglyceride; the hydrogenated olive oil derivative is a combination of hydrogenated olive oil ethylhexyl oleate and hydrogenated olive oil unsaponifiables;

the ecological nutrient solution is specifically a mixture of inulin, water and alpha-glucan oligosaccharides.

2. An anti-aging repair essence emulsion according to claim 1, wherein the vitamins and their derivatives are retinol and retinol palmitate, the weight ratio of retinol to retinol palmitate is (1-5): (2-14).

3. The anti-aging repair essence emulsion of claim 1, wherein the phytoglycogen is extracted from at least one of corn, barley, oat, buckwheat, sorghum, rye, broad bean, mung bean, pea, banana, gingko, chestnut, and sea buckthorn.