CN114287434B - Insecticidal composition containing fluchcordinilipole - Google Patents
Insecticidal composition containing fluchcordinilipole Download PDFInfo
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- CN114287434B CN114287434B CN202210040024.4A CN202210040024A CN114287434B CN 114287434 B CN114287434 B CN 114287434B CN 202210040024 A CN202210040024 A CN 202210040024A CN 114287434 B CN114287434 B CN 114287434B
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention belongs to the technical field of pesticide compounding, and in particular relates to an insecticidal composition containing flushcordifolia and application thereof, and the insecticidal composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is flushcordifolia, the active ingredient B is a compound shown as a formula (I), and the mass ratio of the active ingredient A to the active ingredient B is 1:40-36:1. The composition and the preparation thereof can effectively prevent and treat various phytophagous pests, delay the generation of drug resistance of the pests and reduce the use amount of chemical pesticides.
Description
Technical Field
The invention belongs to the technical field of pesticides, and particularly relates to an insecticidal composition containing fluchcordinilipole and application of the insecticidal composition in controlling phytophagous pests in agriculture, forestry and gardening.
Background
Fluchlordinipro is an independently developed compound from my company and the patent for the compound (CN 106977494B) was granted on month 4 and 30 of 2021. Fluchloridinitrilole belongs to benzamide pesticides, and can efficiently activate insect ryanodine receptors so as to excessively release calcium ions in calcium libraries in cells, thereby leading to death of insect paralysis. The chemical name is as follows: 3-bromo-1- (3-chloropyridin-2-yl) -N- [4, 6-dichloro-3-fluoro-2- (methylcarbamoyl) phenyl]-1H-pyrazole-5-carboxamide of formula: c (C) 17 H 10 BrCl 3 FN 5 O 2 Relative molecular mass (by 2009 international relative atomic mass): 521.56, melting point: the solubility in water is 0.711mg/L at 238-240 ℃, and the chemical structural formula is as follows:
the chemical name of the compound shown in the formula (I) is N- (1-methylcyclopropyl) -2- (3-pyridyl) -2H-indazole-4-carboxamide, the English chemical name is N- (1-methylyclopropyl) -2- (3-pyridinyl) -2H-indazole-4-carboxamide, and the chemical structural formula is:
in the actual process of agricultural production, single administration easily leads to drug resistance of pests. The composition of different varieties is compounded, which is a common method for preventing and controlling resistant pests, and the composition of different varieties is compounded to judge whether a certain compounding has synergistic, additive or antagonistic effect according to the actual application effect. In most cases, the compounding effect of the pesticide is additive effect, the actual synergistic effect is less, and especially the compounding with obvious synergistic effect and high co-toxicity coefficient is less. Through the compounding research of the inventor, the fluchcord inilipole and the compound shown in the formula (I) can generate good synergism, and the related report about the compounding of the fluchcord inilipole and the compound shown in the formula (I) is not disclosed.
Disclosure of Invention
The invention aims to provide the insecticidal composition containing fluchcordinilipole, which has the advantages of synergistic effect, low use cost and good control effect.
An insecticidal composition containing fluclodinitrilmide comprises an active ingredient A and an active ingredient B, wherein the active ingredient A is fluclodinitrilmide, and the active ingredient B is a compound shown in a formula (I); the structural formula is as follows:
the mass ratio of the active component A to the active component B is 1:40-36:1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:40, 1:36, 1:28, 1:24, 1:20, 1:16, 2:25, 1:8, 1:4, 2:7, 3:8, 2:3, 3:1, 4:1, 8:1, 20:1, 25:1, 30:1, 36:1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:36-20:1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:28-4:1;
further, the mass ratio of the active ingredient A to the active ingredient B is 1:24-3:8;
further, based on 100 weight percent of the total weight of the insecticidal composition, the sum of the contents of the active ingredient A and the active ingredient B in the insecticidal composition is 1 to 80 weight percent;
in embodiments, the sum of the contents of the active ingredient A and the active ingredient B in the insecticidal composition is 10 to 30wt%, for example, the sum of the contents of the active ingredient A and the active ingredient B in the insecticidal composition is 18wt%, 26wt%, 32wt%, 33wt%, 34wt%, 40wt%.
The insecticidal composition of the invention can be prepared by a common processing method known to those skilled in the art, namely, after the active ingredient is mixed with a liquid solvent or a solid carrier, one or more surfactants such as wetting agents, dispersing agents, emulsifying agents, thickening agents, disintegrating agents, antifreezing agents, antifoaming agents, solvents, stabilizing agents, penetrating agents, carriers and the like are added;
further, the wetting agent is selected from one or a mixture of more of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, nekal BX, wetting penetrating agent F, chinese honeylocust fruit powder, silkworm excrement or soapberry powder;
further, the dispersing agent is selected from one or more of polycarboxylate, lignosulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, calcium alkylbenzenesulfonate, naphthalene sulfonic formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether phosphate, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ether or glycerin fatty acid ester polyoxyethylene ether;
further, the emulsifier is selected from one or more of nonylphenol 500# (calcium alkylbenzenesulfonate), OP series phosphate (nonylphenol polyoxyethylene ether phosphate), 600# phosphate (phenylphenol polyoxyethylene ether phosphate), styrene polyoxyethylene ether ammonium sulfate, magnesium alkyldiphenyl ether disulfonate, triethanolamine salt, nonylphenol 400# (benzyl dimethyl phenol polyoxyethylene ether), nonylphenol 700# (alkylphenol formaldehyde resin polyoxyethylene ether), nonylphenol 36# (phenethyl phenol formaldehyde resin polyoxyethylene ether), nonylphenol 1600# (phenethyl phenol polyoxyethylene polypropylene ether), ethylene oxide-propylene oxide block copolymer, OP series (nonylphenol polyoxyethylene ether), BY series (castor oil polyoxyethylene ether), nonylphenol 33# (alkylaryl polyoxyethylene polyoxypropylene ether), span series (sorbitan monostearate) polyoxyethylene ether), tween series (sorbitan polyoxyethylene ether) or AEO series (fatty alcohol polyoxyethylene ether);
further, the thickener is selected from one or more of xanthan gum, polyvinyl alcohol, bentonite, carboxymethyl cellulose or magnesium aluminum silicate;
further, the disintegrating agent is selected from one or a mixture of more of bentonite, urea, ammonium sulfate, aluminum chloride, low-substituted hydroxypropyl cellulose, lactose, citric acid, succinic acid or sodium bicarbonate;
further, the antifreezing agent is selected from a mixture consisting of one or more of ethylene glycol, propylene glycol, glycerol or urea;
further, the defoamer is selected from one or a mixture of more of silicone oil, silicone compounds, C10-C20 saturated fatty acid compounds or C8-C10 fatty alcohol compounds;
further, the solvent is selected from the group consisting of N, N-dimethylformamide, cyclohexanone, toluene, xylene, dimethyl sulfoxide, methanol, ethanol, trimethylcyclohexanone, N-octyl pyrrolidone, ethanolamine, triethanolamine, isopropylamine. N-methylpyrrolidone, propanol, butanol, ethylene glycol, diethylene glycol, ethylene glycol methyl ether, butyl ether, ethanolamine, isopropylamine, ethyl acetate or acetonitrile;
further, the stabilizer is selected from one or a mixture of more of epoxidized soybean oil, epichlorohydrin, BHT, ethyl acetate and triphenyl phosphate;
further, the penetrating agent is selected from one or a mixture of more of penetrating agent JFC (fatty alcohol polyoxyethylene ether), penetrating agent T (diisooctyl maleate sulfonate), azone or organic silicon;
further, the carrier is one, two or three of a solvent or a filler, and water is preferably deionized water;
further, the filler is selected from one or a mixture of more of kaolin, diatomite, bentonite, attapulgite, white carbon black, starch or light calcium carbonate;
all of the above materials are commercially available.
The insecticidal composition can be processed into any agriculturally acceptable dosage form, and the dosage form of the insecticidal composition comprises wettable powder, suspending agent, dispersible oil suspending agent, microemulsion and aqueous emulsion.
The invention also provides application of the insecticidal composition containing fluchcordinilipole in preventing and controlling agricultural, forestry and gardening phytophagous pests;
further, the phytophagous insect is chewing, piercing and sucking type and rasping type mouth parts insect.
The chewing mouthpart pest includes: pseudophaga species (adonites spp.), strongylodes (adonites orana), geotrichum species (Agrotis spp.) (rootworm), geotrichum candidum (Agrotis ipsilon) (black rootworm), armyworm (Alabama argillacea), cotton leaf looper (cotton leaf worm), amoeba curena, amyelosis transitella (navel orange borer), anacamptodes defectaria, peach stripe moth (Anarsia lineatella) (peach branch moth), jute spodoptera (Anomis sabulifera) (jote looper), dawsonia mukul moth (An tica rsia g emma ta lis), fruit tree looper (Archi ps argyrospila) (fruittree leafroller) rose leaf rollers (armyworm), armyworm species (Argyrotaenia spp.) (tortricid moths), orange leaf rollers (Argyrotaenia citrana) (orange tortriax), autophaga gamma, bonagota cranaodes, indica butterfly (boro cinnara) (rice leaf rollers), bucculatrix thurberiella (cotton leaf perforator), leptosphaera species (caloglycea spp.) (leaf worms), ca pua reticulana, peach moths (Carposina niponensis) (peach fructi) species (Chilo spp.)), mango spodoptera (Chlumetia transversa) (mango shoot borer), rose leaf rollers (Choristoneura rosaceana) (rose oblique leaf rollers (obliquebanded leafroller))), mango spodoptera (Chlumetia transversa) (mango shoot borer), rose leaf rollers (Choristoneura rosaceana), noctuid species (chrysodexis spp.), rice leaf roller She Yeming (Cnaphalocerus medinalis), bean flour butterfly species (Colias spp.), lychee line moth (Conpomorpha cramerella), amomum armyworm (Cossus) (carpenter moth) species (Crambus spp.), meadow moth (Sod webworm), plum fruit borer (cydiabrona) (Mei Guoe (plus fructi moth)), pear fruit moth (Cydia molesta) (oriental fruit moth), cydia nilla (pea moth), apple fruit moth (Cydia pomonella) (codling moth)), apple fruit moth (codling moth) Darnea diabata, diaphania spp (stem borers)), orthosiphon (diaphraea spp), orthosiphon (Diatraea saccharalis) (sugarcane borer), southwestern corn borer (Diatraea graniosella) (southwestern corn borer (southwester corn borer)), orthosiphon (earia spp)), earthwest diamond (earia insolata) (Egyptian cotton bollworm), emerald diamond (earia virella) (rough northern bollworm), ecdytopopha aurantianum, orthosiphon (Elasmopalpus lignosellus) (corn borer (lesser cornstalk borer)), epiphysias postruttana (apple brown leaf roller (light brown apple moth)) Pink moth (Ephesia spp.) (floor moths), pink moth (Ephestia cautella) (almond moth), nicotiana tabacum (Ephestia elutella) (tobacco moth (tobbaco moth)), mediterranean powder borer (Ephestia kuehniella) (Mediterranean moth (Mediterranean flour moth)), epimedes spp.), fabricius noctiluca (Epinotia apoma), musa butterfly (Erionota thiax) (banna skip), ligustrum japonicum (Eupoecilia ambiguella) (grape leaf roller), euxoa augustis (primordica (armyworm) and Feltia spp.) (cut beetles), gortynia spp.) (stem borers)) the species of the genus Heliothis (Heliothis armyworms) (Grapholita molesta) (Heliothis armyworms (oriental fruit moth)), heliothis armyworms (Hedylepta indicate) (bean leaf webber), the species of the genus Cephalotaria (Heliothis armyworms p.) (noctuid), the species of the genus Heliothis (Helicover paarmigera), the species of the genus Heliothis (Heliothis zea), the species of the genus Heliothis (Heliothis spp.); the plant species include Spodoptera frugiperda (Heliothis virescens), spodoptera frugiperda (Hellula undalis), indabella species (Indabella spp.), solanum lycopersicum (Keiferia lycopersicella), solanum lycopodii (Leucinodes orbonalis), apocynum venetum (Leucoptera malifoliella), apocynum species (Lithocarpus spp.), and Trigonella species (Lithocarpus spp.), the plant species include, for example, a grape leaf moth (grape fruit moth), a Loxagrotis species (Loxagrotis spp.), a Loxagrotis albicosta (western bean rootworm (western bean cutworm)), a Lymantria dispar (Jeep moth), a peach moth (Lyonetia clerkella) (apple leaf moth), a Mahasena corbetti (oil palm bag moth), a sky moth (tent caterpillars), a cabbage looper (Mamestra brassicae), a bean pod borer (Maruca testulalis), a bag moth (metisana), a plant Mythimna unipuncta (true armyworm), neoleucinodes elegantalis, three-point water moth (Nymphula depunctalis), winter inchworm (Operophthera brumata), corn borer (Ostrinia nubilalis) (European corn borer (European corn borer)), oxydia velutia, pandemis cerasana (Plutella xylostella (common currant tortrix)), apple brown moth (Pandemis heparana) (brown apple tortrix), african red butterfly (Papilio demodocus), red bell moth (Pectinophora gossypiella) (pink bollworm), peridroma species (Peridroma spp.) (rootworm), black cutworm (Peridroma saucia) (omnix variegata) (variegated cutworm)), coffee leaf miner (Perileucoptera coffeella) (white coffee leaf miner (white coffee leafminer)) Tuber moth (Phthorimaea operculella) (potato tuber moth), citrus leaf miner (Phyllocnisitis citrella), plutella species (Phyllonorycter spp.), cabbage butterfly (Pieris rapae), alfalfa green night moth (Plathypena scabra), indian Gu Bane (Plodia interpunctella), plutella xylostella (Plutella xylostella) (plutella xylostella (diamondback moth)), polychrosis viteana (grape leaf moth) and fruit nest moth (Prays endocar pa), olive nest moth (Prays oleiferae) (olea europa), pseudolites species (pseudolites spp) (noctuid), pseudaletia unipunctata (plutella xylostella (armyworm), soybean looper (Pseudoplusia includes) (stem borer (Rachipleusia nula), three-point moth (Scirpophaga incertulas), moth species (sea spp) (plutella xylostella), diamond back moth (sepia semens (sepa), sepia semens (sepa) and stem borers (48), olive moth (Prays) and other than (17), pseudolites (Prays), pseudolites (sepa), pseudolites (17), pseudolites (17), pseudaletia unipunctata (pseudolites), 32 (pseudolites (armyworm), 32) and (plutella xylostella) stem borer) and (35 Clothes moth (Tineola bisselliella) (negative bag moth (webbing clothes moth)), spodoptera litura (trichlorsia ni) (cabbage caterpillar), tomato spotted fly (Tuta absorber);
the piercing-sucking mouthpart pest comprises: stinkbug (Acrosternum hilare) (green stinkbug), american Gu Changchun (Blissus leucopterus) (green bug), potato plant bug (Calocoris norvegicus), lygus lucorum (Acrosternum hilare) (green stinkbug), american Gu Changchun (Blissus leucopterus) (green bug), potato plant bug (Calocoris norvegicus), (aphids), scale, whiteflies (white flies), leafhoppers (leaf hoppers)), pea aphids (Acrythosiphon pisum) (pea aphids), sphagnum species (Adelges spp), cabbage bemises (Aleurodes proletella), spiral Bemisia (Aleurodicus disperses), silk white fly (Aleurothrixus floccosus) (cotton fly) the species of the genus Lecanis (Aluacaspis spp.), the species of the genus Lecanis (Aonidiella aurantii) aphid (Aphis spp.), aphis gossypii (Aphis gossypii), aphis pomi (Aphis pomi), aphis long-hair aphid (Aulacorthum solani) (foxglove aphid), the species of the genus Lepidium (Bemisia spp.) (white fly), silver leaf white fly (Bemisia argentifolii), sweet potato white fly (Bemisia tabaci) (sweet potato white fly), myzus bipartita (Brachycolus noxius), asparagus cochinchinensis (Brachycorynella asparagi) (aphid (asparagus aphi)), brevennia rehi, brassica oleracea (Brevicoryne brassicae), the species of the genus Lepidium (Cerrens spp.) The plant species may be selected from the group consisting of Ericerus pela (Ceroplastes rubens) (Ericerus pela), ericerus species (Chionasepis spp.), ericerus species (Choysomphalus spp.), plantago (Dysaphis plantaginea) (Red apple Aphis) and Endocarpium species (Empaca spp.), aphis apple (Eriosoma lanigerum), erica (Icerus pela) and Purcha (Purpura) (Purpura (cottony cushion scale)), ericerus mangifer and leaf hoppers (Idioscopus nitidulus) (mango leaf hoppers), bemisia (Laodelphax striatellus), lepidus species (Lepidopaps spp.), aphis species (Macrosi spp.), euphorbia (Macrosiphum euphorbiae), myzu (Macrosiphum granarium), myzu (Macrosiphum rosae) (Rose), macrosteles quadrilineatus (asplague), myzu (3884), tataria (32), pythium (48), pycis (35) (leaf hoppers (35), pycis (45) and (45) of the plant species (leaf hoppers (Laodelphax striatellus), lepidus (yellow leaf hoppers (35), lepida (yellow leaf hoppers (35), and Pypo (yellow rice hoppers (yellow leaf hoppers) and other than the plant species (yellow rice (yellow leaf hoppers) of the plant species (yellow rice) and other than Pypo) of the plant species (yellow rice) of the plant species) The genus mealybugs (plagiocrocus spp.) (mealybugs), the genus mealybugs (Pseudococcus spp.) (mealybugs), the genus mealybugs (Pseudococcus brevipes) (mealybugs (pine apple mealybug)), the species mealybugs (Quadraspidiotus perniciosus) (mealybugs (San Jose scale)), the genus of pipe aphids (rhopalosihum spp.)), the species corn aphids (Rhopalosiphum maida) (corn She Ya (corn leaf aphid)), the species corn pipe aphids (Rhapalosiphum padi) (oat bird-cherry aphid), the species pearl mealybugs (Saisseria spp.)), the species olive mealybugs (Saissiti oleae), the species wheat aphids (Schizaphis graminum) (green aphids (green parts)), the species wheat aphids (Sitobia English grain aphid)), the species white planthoppers (Sogatella furcifera), the species corn mealybugs (yellow tube), the species mealybugs (yellow smoke lid.) (yellow meal spring.);
the rasp sucking mouthpart pest comprises: thrips tabaci (Frankliniella fusca) (tabaci Thrips), frankliniella medicago (Frankliniella occidentalis) (western flower Thrips (western flower Thrips)), frankliniella shultzei, frankliniella williamsi (corn Thrips), thrips (Heliothrips haemorrhaidalis) (greenhouse Thrips (greenhouse Thrips)), syruping abdominal (Riphiphorothrips cruentatus), thrips sp, thrips citri (Scirtothrips citri) (citrus Thrips), thrips thearubiginis (Scirtothrips dorsalis) (Thrips thearubiginis (yellow tea Thrips)), taeniothrips rhopalantennalis, and Thrips sp;
further, the chewing pests include plutella xylostella, asparagus caterpillar, prodenia litura, spodoptera frugiperda, chilo suppressalis, cotton bollworm and cabbage caterpillar;
further, the piercing-sucking mouthparts pests comprise aphids, whiteflies and rice planthoppers;
further, the rasping type mouth parts pests comprise thrips tabaci, thrips palmi, thrips florida, thrips frankincense, thrips theae;
the present invention also provides an insecticidal composition comprising fluchloredinitrilole as described above in an effective amount to be applied to the pest to be controlled or to the medium in which it is growing.
The invention has the advantages that:
(1) After being compounded with a compound shown in a formula (I), the fluchcordinilipole has obvious synergy and lasting effect;
(2) The pesticide composition has higher prevention effect on chewing type, piercing-sucking type and rasping type mouthpart pests of crops;
(3) The dosage of the pesticide is reduced, the residual quantity of the pesticide on crops is reduced, and the environmental pollution is lightened;
(4) Is safe to people and livestock and environment-friendly.
Description of the preferred embodiments
Preparation example 1:
18% fluchcordinilipole, compound suspension of formula (I) (1:8)
The formula comprises the following components: fluchloridinitrilole 2%, compound 16% of formula (I), polyether 3.5%, phenethyl phenol polyether phosphate 2.5%, guerbet alcohol polyoxyethylene ether 1.5%, magnesium aluminum silicate 1%, xanthan gum 0.2%, propylene glycol 5%, benzisothiazolinone 0.02%, organosilicon defoamer 0.4%, and deionized water for the rest;
the preparation method comprises the following steps: according to the formula proportion, the active ingredients, the surfactant and other functional auxiliary agents are sequentially placed in a reaction kettle, water is added and mixed uniformly, high-speed shearing and wet sanding are carried out, and finally, the suspending agent is obtained by homogenizing and filtering.
Preparation example 2:
34% fluchcordinilipole, compound suspension of formula (I) (2:15)
The formula comprises the following components: fluchcordinilipole 4%, compound of formula (I) 30%, polyether 2%, polycarboxylate 1.5%, naphthalene sulfonate amol NN 89063%, iso-tridecanol polyoxyethylene ether 2%, magnesium aluminum silicate 1%, xanthan gum 0.2%, propylene glycol 5%, benzoic acid 0.1%, organosilicon defoamer 0.4%, and deionized water for the rest;
the preparation method comprises the following steps: the same as in preparation example 1.
Preparation example 3:
32% fluchcordinilipole, compound suspension of formula (I) (1:7)
The formula comprises the following components: fluchloridinitrilole 4%, compound of formula (I) 28%, lignosulfonate 2%, polycarboxylate 2.5%, alkylphenol polyoxyethylene phosphate 3%, magnesium aluminum silicate 1%, xanthan gum 0.3%, glycerol 4.5%, benzoic acid 0.1%, silicone defoamer 0.4%, and deionized water for the rest;
the preparation method comprises the following steps: the same as in preparation example 1.
Preparation example 4:
33% fluchcordinilipole, compound Water dispersible granule of formula (I) (1:10)
The formula comprises the following components: fluchcordinilipole 3%, compound 30% of formula (I), sodium lignin sulfonate 8%, alkylaryl polyoxyethylene polyoxypropylene ether 8%, sodium dodecyl benzene sulfonate 4.5%, white carbon black 4.5%, starch 24% and kaolin for the rest;
the preparation method comprises the following steps: according to the formula proportion of the embodiment, the active ingredients are added into a carrier, and the surfactant and other functional additives are added into the carrier, mixed, crushed by air flow, added with 10 to 25 percent of water, and then kneaded, granulated, dried and screened to prepare the water dispersible granule product.
Preparation example 5:
40% fluchcordinilipole, compound Water dispersible granule of formula (I) (1:9)
The formula comprises the following components: fluchcordinilipole 4%, compound 36% of formula (I), sodium lignin sulfonate 4%, alkylphenol polyoxyethylene formaldehyde condensate sulfate 3%, sodium dodecyl benzene sulfonate 5%, sodium dodecyl sulfate 2.5%, white sugar 3%, starch 15%, and kaolin to make up the balance;
the preparation method is the same as in preparation example 4.
Preparation example 6:
26% fluchcordinilipole, dispersible oil suspending agent of formula (I) (1:12)
The formula comprises the following components: fluchlordinilipole 2%, compound of formula (I) 24%,2.5% lignosulfonate, 12% alkylaryl polyoxyethylene polyoxypropylene ether, 3% fatty alcohol polyoxyethylene ether, 2% calcium dodecyl benzene sulfonate, 1% silicon dioxide, 1% organic bentonite, 20%200# solvent oil, methyl oleate make up the balance;
the preparation method comprises the following steps: according to the formula proportion, sequentially placing the active ingredients, the surfactant and other functional additives into a reaction kettle, adding solvent oil, uniformly mixing, shearing at high speed, performing wet sanding, and finally homogenizing and filtering to obtain the dispersible oil suspending agent product.
Comparative example 1
18% fluchcordinilipole N- (1-methylethyl) -2- (3-pyridyl) -2H-indazole-4-carboxamide suspending agent (1:8)
The formula comprises the following components: fluchcordinilipole 2%, N- (1-methylethyl) -2- (3-pyridyl) -2H-indazole-4-formamide 16%, polyether 3.5%, phenethyl phenol polyether phosphate 2.5%, guerbet alcohol polyoxyethylene ether 1.5%, magnesium aluminum silicate 1%, xanthan gum 0.2%, propylene glycol 5%, benzisothiazolinone 0.02%, organosilicon defoamer 0.4%, and deionized water for the balance;
the preparation method is the same as that of preparation example 1.
Test agent: 90% of a compound original drug shown in a formula (I), 89% of an N- (1-methylethyl) -2- (3-pyridyl) -2H-indazole-4-carboxamide original drug and 90% of a fluchlodinitrilole original drug are provided by a group development center.
Indoor activity test cases:
the test method comprises the following steps:
adults of the order thysanoptera: a glass tube rolling method;
test insect age: the sensitive population of indoor breeding for multiple generations is adopted, and healthy and consistent thysanoptera female adults are selected.
After the glass tube is uniformly rolled with 250ul of liquid medicine, the cabbage leaves are punched into round pieces with the diameter of 1.5cm by a puncher, fresh cabbage leaves are soaked in the liquid medicine by forceps for 10 seconds and then taken out, the cabbage leaves are placed in the glass tube after the liquid medicine is naturally dried, 15 thysanoptera female adults are sucked into the glass tube by a fluke device, and the glass tube is sealed by a 200-mesh gauze.
Each treatment was repeated 4 times with blank treatment as a control. The treated test insects are placed in an artificial intelligent culture room with the temperature of 26+/-1 ℃ and the illumination time of L, D=16h and 8h, and the relative humidity of the artificial intelligent culture room is 60 percent for feeding.
Lepidopteran larvae: a method for combining leaf soaking and insect soaking;
test insect age: and selecting healthy and consistent lepidoptera second-age larvae by adopting a sensitive population which is fed indoors for multiple generations.
Soaking fresh cabbage slices in the liquid medicine for 10s with forceps, taking out, naturally airing the liquid medicine, placing the cabbage slices in a culture dish filled with moisturizing filter paper, placing 20 lepidoptera second-instar larvae in the liquid medicine for 5s, sucking the excessive liquid medicine with the filter paper, and placing test insects in the culture dish immersed with the leaf at corresponding concentration.
Each treatment was repeated 4 times with blank treatment as a control. The treated test insects are placed in an artificial intelligent culture room with the temperature of 26+/-1 ℃ and the illumination time of L, D=16h and 8h, and the relative humidity of the artificial intelligent culture room is 60 percent for feeding.
And (5) after the medicament treatment, investigating the death condition of the test insects for 48 hours, judging that the death standard of the test insects is that the insects shrink obviously or the needling cannot climb normally, and recording the death number.
Data statistics and analysis: the mortality rate of the blank control is less than 5% without correction; the death rate of the blank control is 5-10%, and the death rate needs to be corrected; the mortality rate of the blank control is more than 10%, and the test is needed to be carried out again.
The calculation formula is as follows:
in LC form 50 The agent having a relatively small value is a standard agent, and its toxicity index TI is 100.
Theoretical toxicity index of the mixture tti=ti A ×P A +TI B ×P B
Wherein: p (P) A 、P B The weight ratio of the active ingredients A, B in the composition is respectively.
Statistical analysis of the data was performed with IBM Spss statistics software.
Indoor example 1
Toxicity measurement results of Fluchldinitrilmide on frankliniella occidentalis compounded with compound of formula (I)
Table 1 fluchlordiniliprole toxicity determination results analysis Table for Frankliniella occidentalis compounded with Compound of formula (I)
As shown in Table 1, when the compound of formula (I) and flushlioprole are mixed in the range of 1:40-36:1, the co-toxicity coefficient is greater than 80, which indicates that the two compounds are mixed in the range of 1:40-36:1 to show additive or synergistic effect and no antagonism is generated.
When the mixing weight ratio of fluchsporinilipole to the compound shown in the formula (I) is 1:36-20:1, the co-toxicity coefficients are all larger than 120, which indicates that the mixing of the fluchsporinilipole and the compound shows a synergistic effect in the weight ratio range; when the mixing weight ratio of fluchcordinilipole to the compound of the formula (I) is 1:28-4:1, the co-toxicity coefficients are all greater than 130, which indicates that the fluchcordinilipole and the compound of the formula (I) show obvious synergy in the mixing weight ratio range.
Indoor example 2
Toxicity measurement results of Fluchloridinitrilole in combination with Compound of formula (I) on Spodoptera frugiperda
Table 2 fluchlordiniliprole toxicity measurement results analysis Table of Spodoptera frugiperda compounded with the Compound of formula (I)
As shown in Table 2, the cotoxicity coefficients of flushcordinipro and the compound of formula (I) are greater than 120 when the ratio of the compound to spodoptera frugiperda is 1:28-20:1, which indicates that the synergistic effect is shown by the combination of the flushcordinipro and the compound of formula (I).
When the mixing weight ratio of fluchcordinilipole to the compound of the formula (I) is 2:25-2:7, the co-toxicity coefficients are both greater than 150, which indicates that the fluchcordinilipole and the compound of the formula (I) show obvious synergy in the mixing weight ratio range.
Indoor example 3
Toxicity determination results of flushcordinilipole and Compound of formula (I) on Bemisia tabaci
Table 3 fluchlordiniliprole toxicity test results analysis Table for Bemisia tabaci compounded with Compound of formula (I)
As shown in Table 3, when the flushcordinilipole and the compound shown in the formula (I) are used for treating bemisia tabaci in the range of 1:24-8:1, the co-toxicity coefficient is greater than 120, which indicates that the flushcordinilipole and the compound shown in the formula (I) are mixed in the range of 1:24-8:1 to show additive or synergistic effect, and no antagonism is generated.
When the mixing weight ratio of fluchcordinilipole and the compound shown as the formula (I) is 1:24-3:8, the co-toxicity coefficients are all more than 130, which indicates that the mixing of the fluchcordinilipole and the compound shows synergistic effect in the weight ratio range.
Example 1 in the field
Field test for controlling whiteflies
Test crop: the preparation method comprises the steps of (1) preparing tomato,
test object: bemisia tabaci (Gennadius) ];
the test is carried out on a greenhouse planting base in Li Gezhuang village of Qingdao city of Shandong province, the test Tian Feili is moderate, and the cultivation conditions are consistent.
The test is provided with 5 mixing treatments, 2 control treatments, 4 times of repetition, random arrangement and 40m cell area 2 . Test of administration in the Bemisia tabaci onset full period, 1 administration, and water consumption of 675kg/hm 2 。
When the medicine is applied, the control is sprayed firstly, and the spraying is sequentially carried out from low concentration to high concentration, and a constant spraying method is adopted, so that uniform spraying is carried out at a constant speed according to the calculated pace. When different medicaments are replaced, the sprayer is cleaned for three times, and water in the spray rod is sprayed out completely.
The test period is good in weather, the daily average air temperature is 25 ℃, the highest air temperature is 32 ℃, the lowest air temperature is 22 ℃ and the relative humidity is 70% on the same day of drug application.
The investigation method comprises the following steps:
investigating the number of insect population base before pesticide application, setting and hanging 5 plants in each cell, and fixedly investigating 3 leaves of each plant; the number of living insects was investigated 3d and 7d after the administration.
And the growth and development conditions and the generation of phytotoxicity of tomatoes are respectively investigated in 3d and 7d after the application.
The drug effect calculation method comprises the following steps:
TABLE 4 control effect of different agents in field on tomato whiteflies
Note that: the control (%) in the above table is the average value of each repetition. Lower case letters represent a significant difference in 5% levels.
From the analysis of the experimental results in table 4, it can be seen that the combination of fluchcordinilipole and the compound of formula (i) has a better control effect on whiteflies, and shows better quick-acting performance and lasting performance. The control effects of 3d,18% fluclodinitrilpro-formula (I) compound suspending agent (1:8), 32% fluclodinitrilpro-formula (I) compound suspending agent (1:7) and 40% fluclodinitrilpro-formula (I) compound water dispersible granule (1:9) are 89.53%, 81.45% and 82.81% respectively; the control effect is increased after the medicine is 7d, the control effects of 18 percent of flushcordinipro le compound suspending agent (1:8), 32 percent of flushcordinipro le compound suspending agent (1:7) and 40 percent of flushcordinipro le compound water dispersible granule (1:9) are respectively 95.37 percent, 92.08 percent and 92.16 percent, and the control effect shows a gradually increasing trend.
Drug safety: in the test process, tomatoes grow normally, and all treatment agents do not cause phytotoxicity to tomato plants at the tested concentration.
Example 2 in the field
Field test for preventing and treating thrips
Test crop: the green Chinese onion is of a Chinese phoenix tree variety;
test object: spring onion thrips (Thrips alliorum Priesner)
The test is carried out on a green Chinese onion base in Peng Guzhuang village of the Jinan City of Shandong province, the soil fertility is moderate, and the field management is consistent.
The test is provided with 5 treatments, 2 control treatments, 4 times of repetition and random arrangement, and the cell area is 50m 2 。
The test is carried out in the full-time period of the green Chinese onion thrips.
The test and the test are carried out on the 6 th and 20 th year of 2020, the application device is an WS-16D guard electric sprayer, the spray head is a single fan-shaped spray head, the working pressure is 0.15-0.4Mpa, and the medicine amount is accurately taken according to the area of a district according to the medicine amount requirement. The day of test application is sunny, and the temperature is 21-33 ℃.
The investigation method comprises the following steps: before the application, a five-point sampling method is adopted in each cell, 6 normally grown onion tubes are selected in each point, the number of the living thrips is counted, and a marking plate is hung; and (3) after the pesticide is applied, investigating the number of living insects in each cell at the position of the hanging tag plate, and calculating the rate of reduction of insect population and the prevention and control effect.
And the growth and development conditions and the occurrence of phytotoxicity of the green Chinese onions are respectively investigated in 3d and 7d after the application.
The drug effect calculation method comprises the following steps:
TABLE 5 prevention and treatment effects of different agents in fields on scallion thrips
Note that: the control (%) in the above table is the average value of each repetition. Lower case letters represent a significant difference in 5% levels.
From the analysis of the experimental results in table 5, it can be seen that the combination of fluchcordinilipole and the compound shown in the formula (I) has better control effect on thrips, and shows better quick-acting property and lasting effect. The control effects of 3d,18% of flushoridinitrilmide-compound suspending agent (1:8) of formula (I), 32% of flushoridinitrilmide-compound suspending agent (1:7) of formula (I) and 40% of flushoridinitrilmide-compound water dispersible granule (1:9) of formula (I) are 90.02%, 82.16% and 83.76% respectively; the control effect is increased after the medicine is 7d, the control effects of 18 percent of flushradilliprol-compound suspending agent of formula (I) (1:8), 32 percent of flushradilliprol-compound suspending agent of formula (I) (1:7) and 40 percent of flushradilliprol-compound water dispersible granule of formula (I) (1:9) are respectively 96.43 percent, 92.07 percent and 92.95 percent, and the control effect shows a gradual increasing trend.
Drug safety: in the test process, the green Chinese onion grows normally, and all treatment medicaments do not cause phytotoxicity to green Chinese onion plants under the tested concentration.
Although the present application describes particular embodiments in detail by way of example, the disclosure of the present application may take various modifications and alternative forms. It should be understood, however, that the disclosure of the present application is not intended to be limited to the particular forms disclosed. On the contrary, the intention is to cover all modifications, equivalents, and alternatives falling within the scope of the disclosure as defined by the appended claims and their legal equivalents.
Claims (10)
1. An insecticidal composition containing fluclodinitrilmide is characterized by comprising an active ingredient A and an active ingredient B, wherein the active ingredient A is fluclodinitrilmide, and the active ingredient B is a compound shown as a formula (I) and has the following structural formula:
the mass ratio of the active ingredient A to the active ingredient B is 1:36-20:1.
2. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient a to the active ingredient B is 1:28 to 4:1.
3. The insecticidal composition according to claim 1, wherein the mass ratio of the active ingredient a to the active ingredient B is 1:24-2:3.
4. A pesticidal composition according to claim 1, wherein the sum of the contents of the active ingredient a and the active ingredient B in the pesticidal composition is 1 to 80% by weight, based on 100% by weight of the total pesticidal composition.
5. The insecticidal composition of claim 4, further comprising an adjuvant selected from one or more of wetting agents, dispersants, emulsifiers, thickeners, disintegrants, freezing point depressants, defoamers, solvents, stabilizers, penetrants, and carriers.
6. The insecticidal composition of claim 5, wherein said insecticidal composition is formulated in any agriculturally acceptable formulation, said formulation comprising wettable powders, suspensions, dispersible oil suspensions, microemulsions, emulsions in water.
7. Use of the insecticidal composition according to any one of claims 1 to 6 for controlling phytophagous pests in agriculture, forestry or horticulture.
8. The use of claim 7, wherein the phytophagous pest is a chewing, piercing or rasping type mouth gag pest.
9. The use of claim 8, wherein said chewing pests include plutella xylostella, spodoptera exigua, spodoptera litura, spodoptera frugiperda, chilo suppressalis, cotton bollworm or cabbage caterpillar;
the piercing-sucking mouthparts pests comprise aphids, whiteflies or rice planthoppers;
the rasping type mouth organ pests comprise thrips tabaci, thrips palmi, thrips florida or thrips theae.
10. The use according to claim 7, wherein the pesticidal composition is applied in an effective amount to the pest to be controlled or to the medium in which it is growing.
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