CN114113648A - Multifunctional reaction intelligent monitoring system - Google Patents
Multifunctional reaction intelligent monitoring system Download PDFInfo
- Publication number
- CN114113648A CN114113648A CN202111359647.XA CN202111359647A CN114113648A CN 114113648 A CN114113648 A CN 114113648A CN 202111359647 A CN202111359647 A CN 202111359647A CN 114113648 A CN114113648 A CN 114113648A
- Authority
- CN
- China
- Prior art keywords
- needle
- reaction
- bottle
- cylinder
- dilution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000006243 chemical reaction Methods 0.000 title claims abstract description 238
- 238000012544 monitoring process Methods 0.000 title claims abstract description 36
- 238000005070 sampling Methods 0.000 claims abstract description 127
- 239000012895 dilution Substances 0.000 claims abstract description 105
- 238000010790 dilution Methods 0.000 claims abstract description 105
- 239000012295 chemical reaction liquid Substances 0.000 claims abstract description 35
- 238000010438 heat treatment Methods 0.000 claims abstract description 21
- 238000003756 stirring Methods 0.000 claims abstract description 16
- 238000004140 cleaning Methods 0.000 claims abstract description 11
- 230000009471 action Effects 0.000 claims abstract description 7
- 238000002474 experimental method Methods 0.000 claims abstract description 6
- 239000007788 liquid Substances 0.000 claims description 111
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 78
- 239000007787 solid Substances 0.000 claims description 54
- 238000003860 storage Methods 0.000 claims description 30
- 239000002699 waste material Substances 0.000 claims description 24
- 238000005406 washing Methods 0.000 claims description 23
- 238000007865 diluting Methods 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 10
- 230000003993 interaction Effects 0.000 claims description 9
- 238000004458 analytical method Methods 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000011068 loading method Methods 0.000 claims description 4
- 230000035484 reaction time Effects 0.000 claims description 4
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000002572 peristaltic effect Effects 0.000 description 36
- 125000003963 dichloro group Chemical group Cl* 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 238000012546 transfer Methods 0.000 description 8
- 230000003111 delayed effect Effects 0.000 description 7
- 238000003786 synthesis reaction Methods 0.000 description 7
- 230000000875 corresponding effect Effects 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 238000001514 detection method Methods 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000007872 degassing Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- -1 instruments Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000012898 sample dilution Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00346—Heating or cooling arrangements
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P90/00—Enabling technologies with a potential contribution to greenhouse gas [GHG] emissions mitigation
- Y02P90/02—Total factory control, e.g. smart factories, flexible manufacturing systems [FMS] or integrated manufacturing systems [IMS]
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Hydrology & Water Resources (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The invention discloses a multifunctional intelligent reaction monitoring system which comprises an operating platform, a central control system, a robot and a ground rail device thereof, a reaction heating and stirring device, a sampling and pipetting dilution device, an electric control device and an operating device, wherein the central control system is used for reaction registration of a laboratory technician, the central control system is respectively in electric signal connection with the robot and the ground rail device thereof as well as the electric control device, the robot and the ground rail device thereof are used for position movement and action execution of the robot, the electric control device is used for receiving instructions and controlling the sampling and pipetting dilution device, the sampling and pipetting dilution device is used for executing sampling, dilution, pipetting, Shimadzu assembly and needle cleaning tasks, and the reaction heating and stirring device is used for stirring reaction liquid and controlling the temperature of the reaction liquid. The invention can intelligently monitor and realize the reaction of all temperatures above-78 ℃, and the automatic operation replaces the manual operation, thereby reducing the labor cost, improving the stability of the experiment and improving the production efficiency.
Description
Technical Field
The invention relates to the technical field of automatic organic synthesis chemical equipment, in particular to a multifunctional reaction intelligent monitoring system.
Background
With the development of automation technology in the fields of biology, chemistry, medical treatment, etc., automation or semi-automation operation has been gradually replacing manual operation, and becomes one of the indispensable means for efficient production. The application of automation in the field of organic chemical synthesis mainly refers to operations of automatically sampling, pipetting, completing dilution of experimental reagents, assembling experimental supplies and the like, and the operations are based on monitoring of experimental reactions.
Traditional reaction monitoring is that the laboratory technician carries out manual sample censorship to the reaction liquid according to own experience and time arrangement, and the laboratory technician oneself makes the judgement again according to the experimental result afterwards and needs the extension time or directly judge that the reaction is ended, and whole monitoring process is very big to laboratory technician's dependence, therefore the cost of labor is higher, and sampling time, judgement foundation also can have individual difference moreover. At present, the chinese patent publication No. CN107402273A discloses an automatic sampling assembly and a three-dimensional automatic sampling system, the automatic sampling assembly can quickly and reasonably press a sample bottle to realize sampling, and a sampling needle can quickly separate from the sample bottle; the Chinese utility model patent with publication number CN207119614U discloses an automatic liquid transferring and cleaning system, which has the advantages that the links of liquid transferring, cleaning, waste liquid discharging and cleaning liquid filling work in parallel in the liquid preparation process, and the waiting time of each link is eliminated or shortened; however, the above prior art can only realize single automatic functions, such as automatic sampling or automatic pipetting and cleaning, and the functions are single, and cannot comprehensively realize the functions of rapid sampling, sample dilution, reaction solution removal, shimadzu bottle assembly and the like of various reactions at different temperatures and on different scales.
Therefore, in this field, need to develop a reaction intelligent detection system, can simulate the experimenter and judge the reaction process to assign appointed instruction to the machine, after the machine received the signal, can in time, accurately operate, guarantee that equipment is under the unmanned circumstances of participating in, monitor and accomplish the experiment, reduced the cost of labor, also make chemical synthesis intelligent, automatic, promote industrial production efficiency.
Disclosure of Invention
In order to solve the technical problems, the invention provides a multifunctional intelligent reaction monitoring system, which comprises an operation table, a central control system, a robot and a ground rail device thereof, a reaction heating and stirring device, a sampling liquid-transferring and diluting device, an electric control device and an operation device, wherein the central control system, the robot and the ground rail device thereof, the reaction heating and stirring device, the sampling liquid-transferring and diluting device, the electric control device and the operation device are all arranged on the operation table, the central control system is used for reaction registration of a laboratory worker, the central control system is respectively in electrical signal connection with the robot and the ground rail device thereof as well as the electric control device, the robot and the ground rail device thereof are used for position movement and action execution of the robot, the operation device is used for sending instructions to the electric control device according to experimental tasks, the electric control device is used for receiving the instructions and controlling the sampling liquid-transferring and diluting device, the sample pipetting and diluting device is used for executing the tasks of sampling, diluting, pipetting, assembling the Shimadzu bottle and cleaning the needle, and the reaction heating and stirring device is used for stirring the reaction liquid and controlling the temperature of the reaction liquid.
Specifically, the sampling pipetting dilution device comprises an X-axis support frame, an X-axis servo motor, an X-axis servo guide rail, an L-shaped connecting block, a Z-axis servo motor, a Z-axis servo guide rail, a large connecting plate, a first small connecting plate, a second small connecting plate, an island jin bottle shell placing block, a centrifugal bottle placing block, a reaction bottle positioning device, a methanol tank, a needle washing tank, a waste discharge tank, an island jin bottle assembling device, an island jin bottle sample loading device, a reaction bottle cap screwing device and a reaction bottle centrifugal bottle interaction device, wherein the X-axis servo guide rail and the X-axis servo guide rail are fixedly arranged at the top end of the X-axis support frame, the L-shaped connecting block is used for connecting the X-axis servo guide rail with the Z-axis servo guide rail, a support block is arranged at the middle position of the L-shaped connecting block, the Z-axis servo motor is fixedly connected with the Z-axis servo guide rail, and the large connecting plate is connected with the Z-axis servo guide rail, the island jin bottle shell is placed the piece and is used for the sample time island jin bottle shell place and when diluting island jin bottle place, the centrifugal flask place the piece and be used for moving the placing of liquid time centrifugal flask, the methyl alcohol groove is used for depositing methyl alcohol, the needle washing groove is used for the washing of sample needle, dilution needle, liquid transfer needle, the groove of wasting discharge is used for carrying out the processing of wasting discharge after the needle washs, island jin bottle sample loading device is used for holding up island jin bottle shell and island jin bottle inner core, reaction flask centrifugal flask interaction device for the reaction liquid removes the completion back, the placing of reaction flask and centrifugal flask and the placing of clean centrifugal flask.
Specifically, be provided with sample needle cylinder, sample needle cylinder connecting block, sample needle fixed block, sample needle slider, sample needle slide rail, sample needle and sample needle guide block on the big connecting plate, sample needle cylinder connecting block fixed mounting is on the sample needle slider, sample needle fixed block fixed mounting is in the bottom of sample needle cylinder connecting block, sample needle guide block fixed mounting is in the bottom of sample needle slide rail, sample needle fixed mounting is in sample needle fixed block and sample needle guide block, the sample needle cylinder can make sample needle cylinder connecting block reciprocate for the sample needle slide rail, the sample needle slide rail is used for making the sample needle reciprocate.
Specifically, still be provided with diluter cylinder, diluter cylinder connecting block, diluter fixed block, diluter slider, diluter slide rail, diluter and diluter guide block on the big connecting plate, diluter cylinder connecting block fixed mounting is on the diluter slider, diluter fixed block fixed mounting is in the bottom of diluter cylinder connecting block, diluter guide block fixed mounting is in the bottom of diluter slide rail, diluter fixed mounting is in diluter fixed block and diluter guide block, the diluter cylinder can make diluter cylinder connecting block reciprocate for the diluter slide rail, the diluter slide rail is used for making the diluter reciprocate.
Specifically, still be provided with on the big connecting plate and move liquid needle cylinder, liquid needle cylinder connecting block, liquid needle slider, liquid needle slide rail, liquid needle fixed block, liquid needle guide block and stock solution storehouse, liquid needle cylinder connecting block fixed mounting is on liquid needle slider, liquid needle fixed block fixed mounting is in the bottom of moving liquid needle cylinder connecting block, liquid needle guide block fixed mounting is in the bottom of liquid needle slide rail, liquid needle fixed mounting is in liquid needle fixed block and liquid needle guide block, liquid needle cylinder can make liquid needle cylinder connecting block reciprocate for liquid needle slide rail, liquid needle slide rail is used for making the liquid needle reciprocate, stock solution storehouse fixed mounting is in one side of moving liquid needle cylinder, just the inside intercommunication of hose and stock solution storehouse is passed through to the inside of liquid needle.
Specifically, still be provided with solid gondola water faucet cylinder, solid gondola water faucet cylinder connecting block, solid gondola water faucet slider, solid gondola water faucet slide rail, solid gondola water faucet guide block and solid gondola water faucet on the big connecting plate, solid gondola water faucet cylinder connecting block fixed mounting is on the solid gondola water faucet slide rail, solid gondola water faucet cylinder fixed mounting is at the top of solid gondola water faucet cylinder connecting block, the solid gondola water faucet cylinder is used for driving solid gondola water faucet and reciprocates, solid gondola water faucet guide block fixed mounting is in the bottom of solid gondola water faucet cylinder connecting block, solid gondola water faucet fixed mounting is in the solid gondola water faucet guide block, the solid gondola water faucet slider can make solid gondola water faucet reciprocate for the solid gondola water faucet slide rail.
Specifically, still be provided with gassing needle cylinder, gassing needle cylinder connecting block, gassing needle slider, gassing needle slide rail and gassing needle guide block on the big connecting plate, gassing needle cylinder connecting block fixed mounting is on the gassing needle slide rail, gassing needle cylinder fixed mounting is at the top of gassing needle cylinder connecting block, gassing needle guide block fixed mounting is in the bottom of gassing needle cylinder connecting block, gassing needle fixed mounting is in the gassing needle guide block, the gassing needle slider can make the gassing needle reciprocate for the gassing needle slide rail.
Specifically, first small connecting plate fixed mounting is on sample needle cylinder connecting block, fixed mounting has the sample rifle cylinder on the first small connecting plate, the bottom fixed mounting of sample rifle cylinder has the sample rifle, the inside intercommunication of hose and sample needle is passed through to the inside of sample rifle.
Specifically, second small connecting plate fixed mounting dilutes on rifle cylinder connecting block, fixed mounting dilutes the rifle cylinder on the second small connecting plate, the bottom fixed mounting who dilutes the rifle cylinder dilutes the rifle, the inside intercommunication of hose and dilution needle is passed through to the inside of diluting the rifle.
Specifically, reaction flask positioner is used for placing the reaction flask, takes a sample and moves the liquid task, reaction flask positioner includes magnetic stirrers, reaction flask constant head tank, reaction flask locator thick stick and rodless cylinder, rodless cylinder fixed mounting is at the top of operation panel, rodless cylinder carries outward and is provided with first straight board, be provided with magnetic stirrers on the first straight board, be provided with the spliced pole on the first straight board, the one end that first straight board was kept away from to the spliced pole is provided with the straight board of second, the through-hole has been seted up to the intermediate position of the straight board of second, the reaction flask constant head tank sets up on the straight board of second, just the reaction flask constant head tank is located the through-hole top, reaction flask location cylinder fixed mounting is in the both sides of the straight board of second.
The reaction bottle cap screwing device is used for unscrewing and screwing back a bottle cap of a reaction bottle, and comprises a cap screwing system cylinder, a cap screwing stepping motor, a cap screwing sliding ring and a cap screwing three-jaw cylinder, wherein the cap screwing stepping motor is fixedly installed on an operation table, the cap screwing system cylinder is fixedly installed at the top end of the cap screwing stepping motor, the cap screwing sliding ring is fixedly installed at the bottom end of the cap screwing stepping motor, and the cap screwing three-jaw cylinder is fixedly installed at the bottom of the cap screwing sliding ring.
Specifically, island jin bottle assembly device is used for equipment island jin bottle shell and island jin bottle inner core, island jin bottle assembly device embraces cylinder and island jin bottle assembly cylinder tightly including island jin bottle assembly setpoint, island jin bottle assembly embraces cylinder fixed mounting on the operation panel, the bottom that cylinder was embraced tightly to island jin bottle assembly is provided with island jin bottle assembly setpoint, island jin bottle assembly cylinder fixed mounting is on the operation panel, just there is the interval between island jin bottle assembly cylinder and the island jin bottle assembly armful cylinder.
Specifically, the reaction heating and stirring device comprises eight heating magnetic stirrers, seven nine-hole reaction trays and four-hole low-temperature tanks, and one four-hole low-temperature tank is arranged.
Specifically, the central control system is further provided with an information recording module, and the information recording module is used for recording time and spectrogram information under each time node.
The invention also provides a monitoring method based on the multifunctional reaction intelligent monitoring system, which comprises the following steps:
according to the reaction temperature registered by the experimenter, the central control system distributes the corresponding reaction tray position for the reaction, the experimenter places the reaction bottle filled with the reaction liquid on the corresponding reaction tray position, and according to the reaction time registered by the experimenter, the central control system performs logic analysis and judgment on the reaction and sends out an instruction to command the robot, the ground rail device and the sampling pipetting dilution device to act;
after the central control system judges that the reaction is started, the robot puts the reaction bottle into the reaction bottle positioning device, the reaction bottle clasping cylinder clasps the reaction bottle for sampling, after the sampling is finished, the reaction bottle clasping cylinder loosens, and the central control system instructs the robot to put the reaction bottle back to the original position;
after the central control system judges that the reaction is finished, the robot clamps the reaction bottle to the reaction bottle positioning device, clamps the centrifugal bottle to the centrifugal bottle placing block, unscrews the reaction bottle cap by the reaction bottle cap screwing device, moves all reaction liquid into the centrifugal bottle, washes the reaction bottle for 2 times, moves the washing liquid into the centrifugal bottle together, screws the reaction bottle cap after completing the liquid transfer, and places the centrifugal bottle and the empty reaction bottle into the reaction bottle centrifugal bottle interaction area;
when the central control system judges that the concentration of the reaction liquid is larger, the robot places the Shimadzu bottle on the Shimadzu bottle shell placing block, the Shimadzu bottle tightly holds the Shimadzu bottle by the cylinder, the sampling needle takes out part of the original reaction liquid, then equal amount of diluent is added, the sample bottle is placed back to the designated position, and the diluting action is repeated until the central control system judges that the concentration of the reaction liquid reaches the proper range.
Compared with the prior art, the invention has the beneficial effects that:
1. the multifunctional intelligent reaction detection system provided by the invention can realize the reaction of all temperatures above-78 ℃, through the setting of the central control system, the central control system can allocate the positions of reaction bottles and judge the reaction logic according to the registration condition of an experimenter, thereby controlling a running sequence to transmit task instructions to a robot and an electric control device, the central control system can automatically allocate a reaction disc with proper temperature according to the registered reaction temperature, the central control system can send sampling instructions at specified time according to the registered reaction duration, and can only judge whether automatic next sampling is needed or not according to the detection result, whether automatic dilution is needed or not, after the reaction is judged to be completed, the central control system can send liquid-moving instructions to complete liquid-moving, and can further set sampling frequency, dilution frequency, liquid-moving frequency, needle-washing frequency and the running flow rate and time of a peristaltic pump, in the whole reaction monitoring process, no experimenter is required to participate, and the system can timely and accurately carry out automatic judgment, automatic task generation and automatic corresponding action, so that the dependence of chemical synthesis on people is reduced, the reaction judgment logic is that the experiential experimenter is simulated to carry out judgment, the difference of the self chemical level irregularity of the experimenter is eliminated, and the accuracy of the reaction judgment is improved;
2. the reaction heating and stirring device and the sampling and pipetting dilution device replace the manual operation of an experimenter, can automatically complete the operations of sampling of reaction liquid, diluting a sample, removing the reaction liquid, assembling an Shimadzu bottle, cleaning a needle and the like, and can realize the functions of quick sampling, pipetting, removing the reaction liquid and assembling the Shimadzu bottle of different temperatures and different scales of reaction by combining the intelligent monitoring of the reaction, so that the chemical synthesis process is automated and intelligent, the labor cost is also reduced, and the accuracy and the stability of the experiment are also improved;
3. the multifunctional intelligent reaction monitoring system provided by the invention occupies a small space, can effectively improve the space utilization rate, and solves the problem of large space occupied by the traditional reaction;
4. the multifunctional intelligent reaction monitoring system provided by the invention can continuously run for 24 hours, and the central control system, the robot, the ground rail device of the robot and the electric control device can ensure that each action node has accurate time record, thereby being beneficial to improving the production efficiency.
Drawings
FIG. 1 is a schematic view of the structure of a reaction heating stirring apparatus of the present invention;
FIG. 2 is a schematic view of the construction of the sample pipetting dilution apparatus of the present invention;
FIG. 3 is a top view of the sample pipetting dilution device of the present invention;
FIG. 4 is a schematic structural view of a reaction flask capping device according to the present invention;
FIG. 5 is a schematic view of the structure of the Shimadzu bottle assembly of the present invention;
in the figure, 101, a magnetic stirrer is heated; 102. a nine-well reaction tray; 103. a four-hole low-temperature tank; 201. a Shimadzu housing placement block; 202. the island jin bottle clasps the cylinder; 203. a centrifuge bottle placement block; 204. a reaction flask positioning device; 205. the reaction bottle tightly holds the air cylinder; 206. a methanol tank; 207. a needle washing groove; 208. a waste discharge tank; 209. a sampling needle cylinder; 210. a sampling gun cylinder; 211. a sampling gun; 212. a sampling needle; 213. a dilution needle cylinder; 214. a dilution gun cylinder; 215. a dilution gun; 216. a dilution needle; 217. a pipetting needle cylinder; 218. a liquid transferring needle; 219. a solid shower cylinder; 220. a solid shower head; 221. an air release needle cylinder; 222. a gas releasing needle; 223. a liquid storage bin; 224. a magnetic stirrer; 225. a rodless cylinder; 301. a cap screwing system cylinder; 302. a screw cap stepper motor; 303. a cover-screwing slip ring; 304. a cap screwing three-jaw cylinder; 401. assembling and positioning points of the Shimadzu bottles; 402. assembling the Shimadzu bottle and holding the cylinder tightly; 403. island jin bottle equipment cylinder.
Detailed Description
The technical solutions of the present invention will be described clearly and completely below, and it should be apparent that the described embodiments are some, but not all, embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Materials, instruments, reagents and the like used in the following examples are commercially available unless otherwise specified. The technical means used in the examples are conventional means well known to those skilled in the art, unless otherwise specified.
The structures, proportions, sizes, and other dimensions shown in the drawings attached to the present specification are intended to be only illustrative of the principles of the invention, it will be understood and appreciated by those skilled in the art that variations and modifications in the structure, modification and other arrangements may be made without departing from the spirit and scope of the invention as defined in the appended claims, the scope of the present invention should not be limited by the scope of the present invention, which is defined by the claims, meanwhile, the terms such as "upper", "lower", "left", "right", "middle" and "a" used in the present specification are for clarity only and are not intended to limit the scope of the present invention, changes and modifications in the relative relationship to each other without substantial technical change should also be considered as the scope of the present invention.
Example one
As shown in fig. 1, the reaction heating and stirring apparatus includes a heating magnetic stirrer 101, a nine-hole reaction tray 102 and a four-hole low-temperature tank 103, the number of the heating magnetic stirrer 101 is 8, the heating magnetic stirrer is fixed on an operation table through a positioning block, and different reaction temperatures are set according to experiment requirements; a 9-hole reaction disc 102 is fixed on the heating magnetic stirrer 101 and used for placing reaction bottles for reaction at normal temperature and above; the four-hole low-temperature tank 103 is fixedly arranged on the heating magnetic stirrer 101 and used for placing a reaction bottle for low-temperature reaction, each hole site of the nine-hole reaction disc 102 can be well stirred, each hole site can reach the same temperature, each hole site of the four-hole low-temperature tank 103 can be well stirred, each hole site can reach the same temperature, and the four-hole low-temperature tank 103 can keep the temperature for 3-5 hours within the range of-78-0 ℃.
As shown in fig. 2-5, the sampling pipetting dilution device comprises an Shimadzu housing placing block 201, an Shimadzu bottle clasping cylinder 202, a centrifuge bottle placing block 203, a reaction bottle positioning device 204, a reaction bottle clasping cylinder 205, a methanol tank 206, a needle washing tank 207, a waste discharge tank 208, a sampling needle cylinder 209, a sampling gun cylinder 210, a sampling gun 211, a sampling needle 212, a diluting needle cylinder 213, a diluting gun cylinder 214, a diluting gun 215, a diluting needle 216, a pipetting needle cylinder 217, a pipetting needle 218, a solid shower cylinder 219, a solid shower 220, a gas needle cylinder 221, a gas release needle 222, a liquid storage tank 223, a magnetic stirrer 224, a transfer mechanism 225, a screw cap system cylinder 301, a screw cap stepping motor 302, a screw cap sliding ring 303, a screw cap three-jaw cylinder 304, an island bottle assembly positioning point 401, an Shimadzu bottle assembly clasping cylinder 402 and an Shimadzu bottle assembly cylinder 403, wherein the range of the sampling gun 211 is set to be 20-200 μ L, the range of the dilution gun is set to be 100-.
The invention provides a monitoring method based on a multifunctional reaction intelligent monitoring system, which comprises the following steps:
according to the reaction temperature registered by the experimenter, the central control system distributes the corresponding reaction tray position for the reaction, the experimenter places the reaction bottle filled with the reaction liquid on the corresponding reaction tray position, and according to the reaction time registered by the experimenter, the central control system performs logic analysis and judgment on the reaction and sends out an instruction to command the robot, the ground rail device and the sampling pipetting dilution device to act;
after the central control system judges that the reaction starts, the robot puts the reaction bottle into the reaction bottle positioning device 204, the reaction bottle holding cylinder 205 holds the reaction bottle tightly for sampling, after the sampling is finished, the reaction bottle holding cylinder 205 is released, and the central control system instructs the robot to put the reaction bottle back to the original position;
after the central control system judges that the reaction is finished, the robot clamps the reaction bottle to the reaction bottle positioning device 204, clamps the centrifugal bottle to the centrifugal bottle placing block, unscrews the bottle cap of the reaction bottle by the reaction bottle cap screwing device, completely moves the reaction liquid into the centrifugal bottle, washes the reaction bottle for 2 times, moves the washing liquid to the centrifugal bottle together, screws the bottle cap of the reaction bottle after completing the liquid transfer, and places the centrifugal bottle and the empty reaction bottle in the reaction bottle centrifugal bottle interaction area by the robot;
when the central control system judges that the concentration of the reaction liquid is larger, the robot places the Shimadzu bottle on the Shimadzu bottle shell placing block, the Shimadzu bottle holding cylinder 202 holds the Shimadzu bottle tightly, the sampling needle 212 takes out part of the original reaction liquid, then equal amount of diluent is added, the sample bottle is placed back to the designated position, and the diluting action is repeated until the central control system judges that the concentration of the reaction liquid reaches the appropriate range.
In one specific embodiment, the steps of operation are as follows:
(I) taking reaction liquid:
step A1: after the set reaction time is reached, the central control system sends an instruction to instruct the robot to grab the reaction bottle to the reaction bottle positioning device 204 and grab the Shimadzu shell to the Shimadzu shell placing block 201.
Step A2: the central control system sends out a sampling instruction. The island jin bottle holding cylinder 202 holds the shell of the island jin bottle tightly, and the reaction bottle holding cylinder 205 holds the reaction bottle tightly; the methanol peristaltic pump is started according to a set flow rate, methanol is flushed into the methanol tank 206, and the methanol peristaltic pump is stopped after a set time is reached.
Step A3: the X-axis servo movement moves the sampling needle 212 over the methanol tank 206; the Z-axis servo lowers the sampling needle cylinder 209 to drive the sampling needle 212 to descend into the methanol tank 206; the sampling gun cylinder 210 descends and rises in a delayed manner to drive the sampling gun 211 to absorb methanol; the Z-axis servo motor ascends to return to the original position, and the sampling needle cylinder 209 ascends to drive the sampling needle 212 to ascend; x-axis servo movement moves the sampling needle 212 over the shimadzu housing placement block 201; the Z-axis servo descends, and the sampling needle cylinder 209 descends to drive the sampling needle 212 to descend into the Shimadzu shell; the sampling gun cylinder 210 descends to drive the sampling gun 211 to input methanol into the Shimadzu; the Z axis servo rises to the original position, and the sampling needle cylinder 209 rises to drive the sampling needle 212 to rise; the sampling gun cylinder 210 is raised; repeat step A3 as the set frequency of methanol pick-up.
Step A4: the dichloro peristaltic pump is started according to the set flow rate, dichloro is flushed into the needle washing groove 207, and the dichloro peristaltic pump is stopped after the set time is reached. The X-axis servo movement moves the sampling needle 212 over the needle wash tank 207; the Z-axis servo descends, and the sampling needle cylinder 209 descends to drive the sampling needle 212 to descend into the needle washing groove 207; the sampling gun cylinder 210 descends and rises in a delayed manner to drive the sampling gun 211 to absorb dichloro; the Z axis servo rises to the original position, and the sampling needle cylinder 209 rises to drive the sampling needle 212 to rise; the X-axis servo movement moves the sampling pin 212 over the waste chute 208; the Z-axis servo descends, and the sampling needle cylinder 209 descends to drive the sampling needle 212 to descend into the waste discharge groove 208; the sampling gun cylinder 210 descends to drive the sampling gun 211 to input the sucked dichloro into the waste discharge groove 208; the Z axis servo rises to the original position, the sampling needle cylinder 209 rises to drive the sampling needle 212 to rise, and the sampling gun cylinder 210 rises; repeat step A4 according to the set frequency of needle washing.
Step A5: the X-axis servo movement moves the degassing needle 222 above the reaction vial positioning device 204; the Z-axis servo descends, the air release needle cylinder 221 descends to drive the air release needle 222 to descend, and holes are punctured and air is exhausted on a gasket of the reaction bottle; the Z axis servo rises to the original position, the air release needle cylinder 221 rises to drive the air release needle 222 to rise.
Step A6: x-axis servo movement moves the sampling needle 212 over the vial positioning device 204; the Z-axis servo descends, and the sampling needle cylinder 209 descends to drive the sampling needle 212 to descend into the reaction bottle; the sampling gun cylinder 210 descends and rises in a delayed manner to drive the sampling gun 211 to suck the reaction liquid; the Z axis servo rises to the original position, and the sampling needle cylinder 209 rises to drive the sampling needle 212 to rise; the X-axis servo moves to move the sampling needle 212 above the Shimadzu housing placing block 201; the Z-axis servo descends, and the sampling needle cylinder 209 descends to drive the sampling needle 212 to descend into the Shimadzu shell; the sampling gun cylinder 210 descends to drive the sampling gun 211 to input the reaction liquid into the Shimadzu; the Z axis servo rises to the original position, and the sampling needle cylinder 209 rises to drive the sampling needle 212 to rise; the sampling gun cylinder 210 is raised; the reaction solution was taken as set and the procedure A6 was repeated.
Step A7: as in step a 4. After the motion is completed, the X-axis servo movement moves the sampling needle 212 to the origin position.
Step A8: and step A7, releasing the island jin bottle holding cylinder 202 and the reaction bottle holding cylinder 205. Allowing the robot to grab the sampled Shimadzu shell to the Shimadzu assembling positioning point 401; the central control system sends a holding instruction to hold the Shimadzu shell tightly by the holding cylinder 402 so as to hold the Shimadzu shell tightly; the central control system sends out an Shimadzu inner core fetching instruction to instruct the robot to grab the Shimadzu inner core to the Shimadzu assembling positioning point 401 from the Shimadzu feeding device; the central control system sends out an Shimadzu bottle assembly instruction to enable the Shimadzu bottle assembly cylinder 403 to descend for assembling the Shimadzu bottles; after time delay, the Shimadzu bottle assembling holding cylinder 402 is loosened, and the Shimadzu bottle assembling cylinder 403 rises; after the assembly is completed, the central control system sends out an instruction to instruct the robot to grab the assembled Shimadzu bottle onto an analysis device for analysis.
Step A9: the central control system sends out an instruction to instruct the robot to grab the reaction bottle from the reaction bottle positioning device 204 and send the reaction bottle back to the original reaction disk position.
(II) reaction liquid dilution:
step B1: after the central control system judges that the sample is too thick through the analysis equipment, the central control system sends an instruction to instruct the robot to place the Shimadzu bottle to be diluted into the Shimadzu bottle shell placing block 201.
Step B2: the central control system sends out dilution frequency, needle washing frequency, flow rate and running time commands of various pumps and dilution starting commands. The island jin bottle holding cylinder 202 holds the island jin bottle to be diluted tightly, the methanol peristaltic pump is started according to the given flow rate and time, the methanol is flushed into the methanol tank 206, and the methanol peristaltic pump is stopped after the time is up.
Step B3: the X-axis servo moves to move the dilution needle 216 above the Shimadzu housing placement block 201; the dilution gun cylinder 214 descends to drive the dilution gun 215 to be in a pressing state; the Z-axis servo descends, and the dilution needle cylinder 213 descends to drive the dilution needle 216 to descend into the Shimadzu; the dilution gun cylinder 214 ascends to drive the dilution gun 215 to absorb the sample; the Z axis servo rises to the original position, and the dilution needle cylinder 213 rises to drive the dilution needle 216 to rise; the X-axis servo moves to move the diluent pin 216 above the waste discharge tank 208; the Z-axis servo descends, and the dilution needle cylinder 213 descends to drive the dilution needle 216 to descend into the waste discharge groove 208; the dilution gun cylinder 214 descends and rises in a delayed manner to drive the dilution gun 215 to input the sucked sample into the waste discharge groove; the Z axis servo rises to the original position, and the dilution needle cylinder 213 rises to drive the dilution needle 216 to rise; repeat step B3 according to the set frequency of sample aspiration.
Step B4: the peristaltic pump of dichloro starts according to given flow rate and time, gush dichlorine into the needle washing groove 207, after the time is reached, the peristaltic pump of dichloro stops. The X-axis servo moves to move the dilution needle 216 above the needle washing groove 207; the Z-axis servo descends, and the dilution needle cylinder 213 descends to drive the dilution needle 216 to descend into the needle washing groove 207 and immerse the dichloro; the air cylinder 214 of the dilution gun descends and rises in a delayed manner to drive the dilution gun 215 to absorb liquid; the Z axis servo rises to the original position, and the dilution needle cylinder 213 rises to drive the dilution needle 216 to rise; the X-axis servo moves to move the diluent pin 216 above the waste discharge tank 208; the Z-axis servo descends, and the dilution needle cylinder 213 descends to drive the dilution needle 216 to descend into the waste discharge groove 208; the dilution gun cylinder 214 descends to drive the dilution gun 215 to input the sucked dichloro into the waste discharge tank 208; the Z axis rises to the original position by servo, the dilution needle cylinder 213 rises to drive the dilution needle 216 to rise, and the dilution gun cylinder 214 rises; repeat step B4 according to the set frequency of needle washing.
Step B5: the X-axis servo moves to move the dilution pin 216 above the methanol tank 206; the Z-axis servo descends, and the dilution needle cylinder 213 descends to drive the dilution needle 216 to descend into the methanol tank 206 and submerge into methanol; the air cylinder 214 of the dilution gun descends and rises in a delayed manner to drive the dilution gun 215 to absorb liquid; the Z axis servo rises to the original position, and the dilution needle cylinder 213 rises to drive the dilution needle 216 to rise; the X-axis servo moves to move the dilution needle 216 above the Shimadzu housing placement block 201; the Z-axis servo descends, and the dilution needle cylinder 213 descends to drive the dilution needle 216 to descend into the Shimadzu; the dilution gun cylinder 214 descends to drive the dilution gun 215 to input the methanol into the Shimadzu bottle; the Z axis servo rises to the original position, and the dilution needle cylinder 213 rises to drive the dilution needle 216 to rise; the dilution gun cylinder 214 is raised; repeat step B5 as the set frequency of methanol pick-up.
Step B6: as in step B4. After the completion of the operation, the X-axis servo moves to move the dilution needle 216 to the origin position. The Shimadzu holding cylinder 202 releases the diluted Shimadzu.
Step B7: after the reaction liquid is diluted, the central control system sends out an instruction to instruct the robot to take the diluted Shimadzu bottle away for further analysis and test.
(III) reaction liquid removing step:
step C1: after the reaction is analyzed, the experimenter confirms that the reaction is completed in the central control system. The central control system sends out an instruction to instruct the robot to grab the reaction bottles needing to be removed from the 9-hole reaction tray 102 or the low-temperature tank reaction tray 103 to the reaction bottle positioning device 204; the robot is instructed to grab a clean centrifuge bottle from the centrifuge bottle reaction bottle interaction area to the centrifuge bottle placement block 203.
Step C2: the central control system sends out the reaction liquid removing and rinsing liquid storage bin frequency, flow speed and operation time instructions of various pumps and a reaction liquid removing starting instruction.
Step C3: the peristaltic pump of the liquid storage bin starts small-flow liquid suction.
Step C4: a reaction bottle holding cylinder 205 on the reaction bottle positioning device 204 holds the reaction bottle tightly; the rodless cylinder 225 extends out to drive the reaction bottle positioning device 204 to move to the lower part of the reaction bottle cap screwing device; the cap screwing system cylinder 301 descends to drive the cap screwing stepping motor 302, the cap screwing slip ring 303 and the cap screwing three-jaw cylinder 304 to descend; the cap screwing three-jaw cylinder 304 tightly holds the cap of the reaction bottle; the stepping motor 302 is started to rotate reversely to drive the cap screwing slip ring to rotate reversely, so that the cap screwing three-jaw cylinder 304 is driven to unscrew the bottle cap of the reaction bottle; the cover screwing system cylinder 301 ascends to drive the cover screwing stepping motor 302, the cover screwing slip ring 303 and the cover screwing three-jaw cylinder 304 (which holds the bottle cover of the reaction bottle tightly) to ascend; the rodless cylinder 225 retracts to drive the reaction flask positioning device 204 to move back.
Step C5: the X-axis servo moves to move the pipetting needle 218 over the vial positioning device 204; stopping small-flow-rate liquid suction by the liquid storage bin peristaltic pump; the Z-axis servo descends, and the liquid transferring needle cylinder 217 descends to drive the liquid transferring needle 218 to descend to the bottom of the reaction bottle; the liquid storage bin peristaltic pump starts liquid suction according to a set flow rate, reaction liquid is sucked into the liquid storage bin 223, the set time is reached, and the Z-axis servo rises to return to the original position; the liquid-transferring needle cylinder 217 ascends to drive the liquid-transferring needle 218 to ascend; the X-axis servo moves to move the pipetting needle 218 above the centrifuge bottle placing block 203; the Z-axis servo descends, and the liquid transferring needle cylinder 217 descends to drive the liquid transferring needle 218 to descend to the bottle mouth of the centrifugal bottle; the liquid storage bin peristaltic pump starts to discharge liquid according to a set flow rate, all reaction liquid in the liquid storage bin 223 is discharged to the centrifuge bottles in the centrifuge bottle placing block 203, after the set time is reached, the Z-axis servo rises to return to the original position, and the liquid transferring needle cylinder 217 rises to drive the liquid transferring needle 218 to rise; stopping spitting liquid by a peristaltic pump of the liquid storage bin, and starting small-flow liquid suction;
step C6: the X-axis servo moves to move the solid shower 220 above the waste discharge groove 208; the Z-axis servo descends, the solid shower cylinder 219 descends, and the solid shower 220 is driven to descend into the waste discharge groove 208; the dichloro peristaltic pump is started according to a set flow rate, gas in the solid shower 220 is discharged into the waste discharge groove 208, and the dichloro peristaltic pump stops running after the set time is reached; the Z axis rises to the original position by servo, and the solid shower cylinder 219 rises to drive the solid shower 220 to rise;
step C7: the X-axis servo moves to move the solid shower 220 above the reaction bottle positioning device 204; the Z-axis servo descends, and the solid shower cylinder 219 descends to drive the solid shower 220 to descend to the bottle mouth of the reaction bottle on the reaction bottle positioning device 204; the dichloro peristaltic pump is started according to a set flow rate, dichloro is sprayed on the inner wall of the reaction bottle through the solid shower 220 and used for washing the reaction bottle, and the dichloro peristaltic pump stops running after the set time is reached; the Z axis rises to the original position by servo, and the solid shower cylinder 219 rises to drive the solid shower 220 to rise;
step C8: the X-axis servo moves to move the pipetting needle 218 over the vial positioning device 204; stopping small-flow-rate liquid suction by the liquid storage bin peristaltic pump; the Z-axis servo descends to drive the liquid transferring needle 218 to descend to the bottleneck of the reaction bottle; the peristaltic pump of the liquid storage bin spits liquid according to a set flow rate; the dichloro peristaltic pump discharges liquid according to a set flow rate, and dichloro enters the reaction bottle through the liquid storage bin 223 and is used for washing reaction liquid on the inner wall of the liquid storage bin 223; after the set time is reached, the peristaltic pump of the dichloro and liquid storage bins stops discharging liquid; the Z axis is servo-lifted to a designated position, and the liquid transferring needle cylinder 217 descends to drive the liquid transferring needle 218 to descend to the bottom of the reaction bottle; the liquid storage bin peristaltic pump starts liquid suction according to a set flow rate, the rinsing liquid of the reaction bottle is sucked into the liquid storage bin 223, the set time is reached, and the Z-axis servo rises to return to the original point position; the liquid-transferring needle cylinder 217 ascends to drive the liquid-transferring needle 218 to ascend; the X-axis servo moves to move the pipetting needle 218 above the centrifuge bottle placing block 203; the Z-axis servo descends, and the liquid transferring needle cylinder 217 descends to drive the liquid transferring needle 218 to descend to the bottle mouth of the centrifugal bottle; the liquid storage bin peristaltic pump starts to discharge liquid according to a set flow rate, all reaction liquid in the liquid storage bin 223 is discharged to the centrifuge bottles in the centrifuge bottle placing block 203, after the set time is reached, the Z-axis servo rises to return to the original position, and the liquid transferring needle cylinder 217 rises to drive the liquid transferring needle 218 to rise; stopping spitting liquid by a peristaltic pump of the liquid storage bin, and starting small-flow liquid suction; step C8 is repeated according to the set frequency.
Step C9: the rodless cylinder 225 extends out to drive the reaction bottle positioning device 204 to move to the lower part of the reaction bottle cap screwing device; the cap screwing system cylinder 301 descends to drive the cap screwing stepping motor 302, the cap screwing sliding ring 303 and the cap screwing three-jaw cylinder 304 (which holds the reaction bottle cap tightly) to descend, and meanwhile, the stepping motor 302 starts to rotate in the forward direction to drive the cap screwing sliding ring to rotate in the forward direction, so that the cap screwing three-jaw cylinder 304 is driven to screw the reaction bottle cap tightly; the cap screwing three-jaw cylinder 304 loosens the cap of the reaction bottle; the cover screwing system cylinder 301 rises to drive the cover stepping motor 302, the cover screwing slip ring 303 and the cover screwing three-jaw cylinder 304 to rise; the rodless cylinder 225 retracts to drive the reaction flask positioning device 204 to move back; the reaction bottle holding cylinder 205 on the rodless cylinder 225 is loosened, and the held reaction bottle is loosened;
step C10: the X-axis servo moves to move the pipetting needle 218 above the needle washing groove 207; stopping the liquid suction of the liquid storage bin peristaltic pump; starting a dichloro peristaltic pump to spit liquid according to a set flow rate, and filling dichloro into the needle washing groove 207; the Z-axis servo descends, and the liquid transferring needle cylinder 217 descends to drive the liquid transferring needle 218 to descend into the needle washing groove 207; stopping spitting the liquid after the operation of the dichloro peristaltic pump reaches the set time; the Z axis rises to the original position by servo, the liquid transferring needle cylinder 217 rises to drive the liquid transferring needle 218 to rise; the X-axis servo moves the pipette needle 218 over the waste tank 208; the Z-axis servo descends, and the liquid transferring needle cylinder 217 descends to drive the liquid transferring needle 218 to descend into the waste discharge groove 208; the liquid storage bin peristaltic pump blows air out of the liquid storage bin 223 according to a set flow rate; the water peristaltic pump is started according to the set flow rate, the inner wall of the liquid storage bin 223 is uniformly washed through the shower head and is discharged into the waste discharge tank 208 from the liquid transfer needle 218, and the water peristaltic pump stops running after the set time is reached; the acetone peristaltic pump is started according to the set flow rate, the inner wall of the liquid storage bin 223 is uniformly washed through the shower head and is discharged into the waste discharge tank 208 from the liquid transfer needle 218, and the operation of the acetone peristaltic pump is stopped after the set time is reached; the dichloro peristaltic pump is started according to the set flow rate, the inner wall of the liquid storage bin 223 is uniformly washed through the shower head and is discharged into the waste discharge tank 208 from the liquid transfer needle 218, and the operation of the dichloro peristaltic pump is stopped after the set time is reached; the peristaltic pump of the liquid storage bin is closed in a delayed mode; the Z axis rises to the original position by servo, the liquid transferring needle cylinder 217 rises to drive the liquid transferring needle 218 to rise; the X-axis servo moves back to the origin position.
Step C11: after the reaction liquid is removed, the central control system sends out an instruction to instruct the robot to grab the reaction bottle and the centrifuge bottle which are removed from the reaction liquid onto the reaction bottle and centrifuge bottle interaction device.
In conclusion, the multifunctional intelligent reaction monitoring system provided by the invention can realize multifunctional reaction and intelligent reaction monitoring, and simultaneously automatically complete a plurality of manual operations such as reaction liquid sampling, dilution, liquid transfer, Shimadzu bottle assembly, needle cleaning and the like based on the intelligent reaction monitoring, thereby solving the problem of high labor cost, enabling the reaction process to be more stable, greatly improving the production efficiency, in addition, time and spectrogram information recording can be carried out at each time node of the reaction, so that an experimenter can check the specific reaction process of the whole reaction in the system, the reaction and monitoring processes do not need the participation of the experimenter, the system can timely and accurately carry out automatic judgment, automatic generation tasks and corresponding actions, the dependence of chemical synthesis on people is reduced, and the difference of the chemical synthesis level irregularity of the experimenter is eliminated, the accuracy of reaction judgment is improved. In summary, the above embodiments are merely preferred embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalents, improvements, etc. made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (15)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111359647.XA CN114113648B (en) | 2021-11-17 | 2021-11-17 | A multifunctional reaction intelligent monitoring system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111359647.XA CN114113648B (en) | 2021-11-17 | 2021-11-17 | A multifunctional reaction intelligent monitoring system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114113648A true CN114113648A (en) | 2022-03-01 |
| CN114113648B CN114113648B (en) | 2024-11-26 |
Family
ID=80396988
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111359647.XA Active CN114113648B (en) | 2021-11-17 | 2021-11-17 | A multifunctional reaction intelligent monitoring system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114113648B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114636588A (en) * | 2022-03-15 | 2022-06-17 | 上海已铼生物科技有限公司 | Sampling and sample matching device used in synthesis process and working method thereof |
| CN114755058A (en) * | 2022-04-07 | 2022-07-15 | 上海已铼生物科技有限公司 | Automatic liquid taking and sample moving system |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105424949A (en) * | 2015-10-15 | 2016-03-23 | 杭州傲敏生物科技有限公司 | Automatic fast analyzer for food safety and application method thereof |
| CN205731220U (en) * | 2016-02-03 | 2016-11-30 | 吉林省谱尼测试科技有限公司 | A kind of can the automatic liquid-feeding experimental provision of heated for controlling temperature |
| CN106841647A (en) * | 2017-01-25 | 2017-06-13 | 江苏柯伦迪医疗技术有限公司 | Automatic clinical chemistry analyzer and method |
| US20180362916A1 (en) * | 2017-06-15 | 2018-12-20 | Timothy Ray Ho | Automated Bioreactor Sampling and Glucose monitoring System |
| CN112665920A (en) * | 2020-12-19 | 2021-04-16 | 北京大学 | Automatic monitoring system for liquid phase synthesis |
-
2021
- 2021-11-17 CN CN202111359647.XA patent/CN114113648B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105424949A (en) * | 2015-10-15 | 2016-03-23 | 杭州傲敏生物科技有限公司 | Automatic fast analyzer for food safety and application method thereof |
| CN205731220U (en) * | 2016-02-03 | 2016-11-30 | 吉林省谱尼测试科技有限公司 | A kind of can the automatic liquid-feeding experimental provision of heated for controlling temperature |
| CN106841647A (en) * | 2017-01-25 | 2017-06-13 | 江苏柯伦迪医疗技术有限公司 | Automatic clinical chemistry analyzer and method |
| US20180362916A1 (en) * | 2017-06-15 | 2018-12-20 | Timothy Ray Ho | Automated Bioreactor Sampling and Glucose monitoring System |
| CN112665920A (en) * | 2020-12-19 | 2021-04-16 | 北京大学 | Automatic monitoring system for liquid phase synthesis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114636588A (en) * | 2022-03-15 | 2022-06-17 | 上海已铼生物科技有限公司 | Sampling and sample matching device used in synthesis process and working method thereof |
| CN114755058A (en) * | 2022-04-07 | 2022-07-15 | 上海已铼生物科技有限公司 | Automatic liquid taking and sample moving system |
| CN114755058B (en) * | 2022-04-07 | 2025-07-11 | 武汉智化科技有限公司 | Automatic liquid sampling system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114113648B (en) | 2024-11-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10254302B2 (en) | Method for clinical examinations and cleaning method therefor | |
| CN114113648A (en) | Multifunctional reaction intelligent monitoring system | |
| JP4254994B2 (en) | Analytical equipment using a disposable reaction vessel | |
| US20030091473A1 (en) | Automated centrifuge and method of using same | |
| US20120134896A1 (en) | Specimen processing system | |
| EP2025418A1 (en) | Automatic analyzer with pipette cleaning | |
| WO2015192331A1 (en) | Nucleic acid extraction apparatus and method of operation thereof | |
| JPH08211068A (en) | Method for operating analysis unit used for different immunological test | |
| EP2273274A1 (en) | Spotting and Picking Processes and Apparatuses | |
| CN109939758A (en) | An automatic blood pretreatment and pipetting platform for blood rheology detection | |
| CN113406346A (en) | Blood sample analyzer | |
| EP3131651A1 (en) | Reaction vessel handling apparatus, testing apparatus, and methods using same | |
| CN114019178A (en) | A kind of automatic immune-biochemical integrated analyzer and using method | |
| WO2025086519A1 (en) | Nucleic acid extraction and conversion integrated machine and use method therefor | |
| CN201974434U (en) | Automation device for fast cleaning sample needles | |
| CN214918846U (en) | Simple plate washing device for enzyme-linked immunosorbent assay | |
| WO2022176556A1 (en) | Automatic analysis device and method for suctioning sample in automatic analysis device | |
| JPH04256857A (en) | Automatic titration apparatus in analyzer and the like | |
| JP4175916B2 (en) | Automatic analyzer | |
| CN112904032A (en) | Small-sized full-automatic chemiluminescence analysis system | |
| CN216696352U (en) | Full-automatic immune biochemical integrated analyzer | |
| CN115932304A (en) | Proteomics sample pretreatment system and treatment method | |
| CN215910503U (en) | Blood sample analyzer | |
| CN113567422B (en) | Portable chemiluminescent detector and control method thereof | |
| CN214310119U (en) | Sample analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |