CN114099579B - Traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof, and preparation method and application thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof, and a preparation method and application thereof.

Description

Traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof, and preparation method and application thereof

Technical Field

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof, and a preparation method and application thereof. Relates to a fumigation liquid which is acceptable for patients and prepared by traditional Chinese medicines of hairyvein agrimonia herb and bud, clematis root, dahurian angelica root, Chinese mugwort leaf, rosemary, centipeda minima, tangerine peel and mint, and is used for treating adenoidal hypertrophy and complications thereof.

Background

Adenoids are also called pharyngeal tonsils and proliferators, and are located in the key areas between the posterior part of the nasal cavity and the pharyngeal portion. Is a part of the pharyngeal lymph ring, belongs to the immune organs of the human body, contains lymphocytes at various developmental stages, has the humoral immunity function and the cellular immunity function, and is the natural defense barrier of the human body. The adenoid body gradually enlarges after birth, physiologically hypertrophy appears in 2-10 years old, the adenoid body is maximum in 6 years old, gradually shrinks after 8 years old, and gradually disappears before puberty. Pathological hypertrophy of adenoids is often seen in children and adolescents, but also in some adults, often combined with chronic tonsillitis.

The children are susceptible to acute rhinitis, allergic rhinitis, influenza and the like in the period of time, repeated chronic infection of adenoids caused by various pathogens is a main pathogenic factor of adenoid hypertrophy, and the detected main pathogenic bacteria are staphylococcus aureus, streptococcus pneumoniae and klebsiella pneumoniae which are fewer than normal flora. If the nose is repeatedly attacked, then the pathologic reproduction of adenoids occurs, the nasal obstruction is aggravated, the nasal cavity drainage is blocked, and the secretion of nasosinusitis of rhinitis stimulates the adenoids to continuously proliferate, so as to form a causal vicious circle.

Adenoids are frequently clinically complicated with various diseases. Such as rhinitis and nasosinusitis, nasal obstruction, watery nasal discharge, mouth opening breathing, salivation, obstructive nasal noise during speaking, snoring in sleep and other symptoms of the patient; the auditory tube is blocked at the pharynx mouth, which can be accompanied by secretory otitis media, resulting in hearing loss and tinnitus, and can cause suppurative or non-suppurative secretory otitis media; can cause children with high fever, vague pain of nasopharynx, headache, general discomfort, and serious nasal obstruction, and snore when breathing with mouth, and the serious patient can cause children obstructive sleep apnea hypopnea syndrome (children OSAHS). Secretions stimulate respiratory mucosa, often cause paroxysmal cough, breathe for a long time, influence facial bone development, grow the maxilla, arch the palatine, and irregular dentition, and are added with listlessness, dull facial expression and insipid appearance, namely 'adenoid appearance and face appearance'.

CN2018112303380 discloses a traditional Chinese medicine composition for treating adenoid hypertrophy and complications thereof, which is mainly prepared from the following traditional Chinese medicines in parts by weight: 0.5-2.0 parts of hairyvein agrimony, 0.5-2.0 parts of clematis root, 0.5-2.0 parts of angelica dahurica, 1-4 parts of folium artemisiae argyi, 1-4 parts of rosemary, 1-5 parts of centipeda minima and 0.1-0.5 part of cucurbitacin. The preparation of the composition also comprises the following traditional Chinese medicines in parts by weight: 0.5-3 parts of dried orange peel and 0.5-3 parts of mint. The preparation of the composition also comprises the following traditional Chinese medicines in parts by weight: 1-1.5 parts of hairyvein agrimony, 1-1.5 parts of radix clematidis, 1-1.5 parts of radix angelicae, 2-3 parts of folium artemisiae argyi, 2-3 parts of rosemary, 2-4 parts of centipeda minima, 0.2-0.4 part of cucurbitacin, 1.5-2.5 parts of pericarpium citri reticulatae and 1.5-2.5 parts of mint. For convenience in use and carrying, the traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof is prepared into an inhalation preparation, and the inhalation preparation comprises but is not limited to a spray, a powder spray or a solution for atomization inhalation, and the inhalation preparation is obtained by a conventional preparation method of the spray, the powder spray or the solution for atomization inhalation.

The fumigation therapy is to act on the affected part with drug effect and heat to generate certain stimulation, so as to open pores of skin and dilate capillary, and the effective components of the medicine can penetrate into skin to reach deep part of muscle, or can be absorbed and circulated to whole body through capillary; or absorbed into lung via oral or nasal administration, and diffused into blood via mucosa; or act on channels and collaterals to stimulate the regulation of nerves and channels and collaterals systems; thereby achieving the purposes of relieving pain and treating diseases. The fumigation therapy integrates heat, humidity and medicine properties, and is popular and advocated for doctors and patients of all ages due to the characteristics of simple and cheap medicines, safety, reliability, remarkable curative effect, wide application range and the like.

Traditional Chinese medicine fumigation has a long history; the earliest fumigating treatise was used as the prescription for fifty two diseases, which is native to silk book of Han tomb of Changsha Mawangdui No. three, and the book was written in the warring period, and the treatment of diseases by steam fumigation of the hot herbs decocted by the Chinese herbs is specifically proposed, such as: hemorrhoid, burn, and insect bite. Until the Qin-Han period, the Fumigation treatment scope was further expanded by the Huangdi's Canon, the Jinkui Yao L ü e of Zhang Zhongjing, the postHan Shu, and so on, and many more additional and perfect Fumigation treatments were proposed to the later ' elbow backup acute prescription ', the ' Xiaopin Fang ', the ' Yuyao Fang ', the ' Xiang Men ' and so on, and the medicine is related to various classified diseases of internal medicine, surgery, orthopedics, gynecology, pediatrics, dermatology, and so on.

Compared with the simple absorption into the lung during atomization and inhalation, the medicament-containing steam with the temperature of about 40 ℃ can be generated during fumigation and acts on the skin and the meridians of the mouth, the nose, the eyes and the face, so that the absorption and permeation are promoted, the meridians of the face can be effectively stimulated, the immune response of the organism is generated, the treatment effect is improved, the secretion of tears and sweat can be promoted, the toxin is eliminated, and the treatment effect is cooperatively exerted.

Disclosure of Invention

In order to solve the technical problems, the invention provides the fumigation solution which has obvious treatment effect on adenoidal hypertrophy and complications thereof and small side effect. The prescription in CN2018112303380 shows that side effects such as skin allergy, erythema and eczema appear during fumigation, the applicability is poor, and the clinical application is not facilitated.

For this reason, the specific technical scheme of the invention is developed again as follows:

the invention provides a composition for treating adenoidal hypertrophy and complications thereof, which is prepared from the following traditional Chinese medicines in parts by weight:

1-1.5 parts of hairyvein agrimony, 1-1.5 parts of clematis root, 1-1.5 parts of angelica dahurica, 1-1.5 parts of folium artemisiae argyi, 1-1.5 parts of rosemary, 1-1.5 parts of centipeda minima, 1-1.5 parts of dried orange peel and 0.1-0.5 parts of mint.

As a preferred scheme of the technology, the raw material medicines for preparing the composition comprise the following components in parts by weight:

1 part of hairyvein agrimony, 1.5 parts of clematis root, 1.5 parts of angelica dahurica, 1.5 parts of folium artemisiae argyi, 1 part of rosemary, 1.5 parts of centipeda minima, 1 part of dried orange peel and 0.5 part of mint.

Preferably, the Chinese medicinal composition is a fumigating liquid.

The fumigation liquid provided by the invention has good curative effect on adenoid hypertrophy and complications thereof, and has the advantages of less side effect and low cost.

On the other hand, the invention provides a preparation method of the traditional Chinese medicine fumigation liquid,

adding water in a volume ratio of 1: 5-1: 10 into the raw materials in parts by weight, soaking for 0.1-2 hours, heating, refluxing, changing into distillation after refluxing for 5-20 minutes, receiving distillate, adding water in a volume ratio of 1: 3-1: 8, continuing to distill, receiving distillate, and mixing the distillate for 2 times.

In another aspect, the invention also provides the application of the composition and the preparation thereof, and the application of the composition and the preparation thereof in medicines for treating adenoid hypertrophy and complications.

The raw material medicaments of the invention are as follows:

agrimony: the product is dried aerial part of Agrimonia polosa ledeb of Rosaceae. Harvesting stems and leaves in summer and autumn when they are flourishing, removing impurities, and drying.

Clematis root: the product is dried root and rhizome of Clematis chinensis Osbeck, Clematis hexapetala pall or Clematis manshurica Pupr of Ranunculaceae. Collected in autumn, removed silt and dried in the sun.

Radix angelicae: the product is dried root of Angelica dahurica (Fisch. ex Hoffm.) Benth.et hook.f. or Angelica dahurica (Fisch. ex Hoffm.) Benth.et hook.f. var.fortusana (Boiss.) Shann et Yuan of Umbelliferae. Collected in summer and autumn when the leaves are yellow, removed fibrous root and silt, and dried in the sun or at low temperature.

Folium artemisiae argyi: the product is dried leaf of Artemisia argyi l v. Picking in summer when blooming, removing impurities, and drying in the sun.

Rosemary: the product is dried leaf of Rosmarinus officinalis of Labiatae. Collecting all the year round, removing impurities, drying in the shade, and drying in the shade.

Centipeda minima: the product is dried whole plant of Centipeda minima (L.) A.Br.et Aschers. Collected in summer and autumn when blooming, washed off silt and dried in the sun.

Dried orange peel: the product is dry mature pericarp of Rutaceae plant Citrus reticulata Blanco and its cultivar. The medicinal materials are classified into pericarpium citri reticulatae and pericarpium citri reticulatae. Picking mature fruit, peeling peel, and drying in the sun or at low temperature.

Mint: the product is dried aerial parts of Mentha haplocalyx Brig. When stems and leaves flourish or flowers bloom to three rounds in summer and autumn, the plants are harvested and cut in parts on a sunny day, and dried in the sun or in the shade.

The traditional Chinese medicine fumigation solution for treating adenoid hypertrophy and complications is obtained by combining clinical experience and repeated test verification on the basis of a collected prescription by the inventor, has the effects of tonifying qi and spleen, and reducing phlegm and resolving masses, and has a good curative effect on adenoid hypertrophy and complications; has quick response, short curative effect, small side effect, few varieties of the used traditional Chinese medicines and cost saving.

Drawings

FIG. 1: comparative example 2 pictures of the face of a patient with adverse events after fumigation treatment.

Detailed Description

Comparative example 1

Raw materials: 20g of hairyvein agrimony, 30g of clematis root, 30g of angelica dahurica, 40g of folium artemisiae argyi, 40g of rosemary, 80g of centipeda minima, 8g of cucurbitacin, 30g of dried orange peel and 50g of mint.

The preparation method comprises the following steps:

adding water with the volume ratio of 1:5 into the raw materials in parts by weight, soaking for 1 hour, heating, refluxing, changing into distillation after refluxing for 15 minutes, receiving distillate, adding water with the volume ratio of 1:5, continuing to distill, receiving distillate, and mixing the distillate for 2 times to obtain the composition.

Comparative example 2

Raw materials: 20g of hairyvein agrimony, 20g of clematis root, 20g of angelica dahurica, 10g of folium artemisiae argyi, 10g of rosemary, 10g of centipeda minima, 1.5g of cucurbitacin, 30g of dried orange peel and 5g of mint.

The preparation method comprises the following steps:

adding water with the volume ratio of 1:5 into the raw materials in parts by weight, soaking for 1 hour, heating, refluxing, changing into distillation after refluxing for 15 minutes, receiving distillate, adding water with the volume ratio of 1:5, continuing to distill, receiving distillate, and mixing the distillate for 2 times to obtain the composition.

Example 1

Raw materials: 30g of hairyvein agrimony, 30g of clematis root, 30g of angelica dahurica, 30g of folium artemisiae argyi, 30g of rosemary, 30g of centipeda minima, 30g of dried orange peel and 3g of mint.

The preparation method comprises the following steps:

adding water with the volume ratio of 1:5 into the raw materials in parts by weight, soaking for 1 hour, heating, refluxing, changing into distillation after refluxing for 15 minutes, receiving distillate, adding water with the volume ratio of 1:5, continuing to distill, receiving distillate, and mixing the distillate for 2 times to obtain the composition.

Example 2

Raw materials: 30g of hairyvein agrimony, 45g of clematis root, 45g of angelica dahurica, 45g of folium artemisiae argyi, 30g of rosemary, 45g of centipeda minima, 30g of dried orange peel and 15g of mint.

The preparation method comprises the following steps:

taking the raw materials in parts by weight, adding water in a volume ratio of 1:5, soaking for 1 hour, heating, refluxing, changing into distillation after refluxing for 15 minutes, receiving distillate, adding water in a volume ratio of 1:5, continuing to distill, receiving distillate, and mixing the distillate for 2 times to obtain the composition.

The following describes the application effect of the product:

clinical observation of traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof

1. Data and method

1.1 clinical data

The patients with adenoids hypertrophy and complications thereof diagnosed from 1 month to 2020 and 5 months in 2019 are all patients in the group, the age is 6-12 years, 200 patients are randomly divided into 80 cases in a treatment group and 120 cases in a control group. Group 5 had no statistical significance in gender, age, course and disease distribution (P > 0.05).

1.2 diagnostic criteria

The clinical manifestations are as follows: intermittent or persistent upper airway obstruction symptoms, including repeated attacks of nasal obstruction, snoring during sleep, mouth opening breathing and even dyspnea. Frequently complicated chronic rhinosinusitis, secretory otitis media, obstructive sleep apnea hypopnea syndrome in children and adenoid face appearance visible in children.

Auxiliary inspection:

(1) nasal endoscopy evaluation:

(2) the imaging examination comprises the following steps of (1) examination of a lateral X-ray film of the nasopharynx part: taking the vertical distance from the most prominent point of the adenoid to the skull base bone surface as the thickness A of the adenoid, and the distance from the rear end of the hard palate to the intersection point of the wing plate and the skull base as the width N of the nasopharynx part, if A/N is less than or equal to 0.60, the range is a normal range, the range is moderate hypertrophy between 0.610 and 0.70, and the range is more than or equal to 0.71, namely the pathologic hypertrophy; secondly, nasopharyngeal CT examination: axial images show that the nasopharyngeal cavity is deformed and narrowed, the posterior naris is blocked to different degrees, and the soft tissue of the posterior wall is thickened. And (3) measuring axial phase, wherein the adenoid index is more than or equal to 0.70.

Infants with nasal endoscopy and imaging support, with partial clinical manifestations, can be diagnosed with adenoid hypertrophy and complications.

1.3 methods of treatment

Control 1 to comparative example 1, control 2 to comparative example 2, treatment 1 to example 1, and treatment 2 to example 2; control group 3 was given water.

Mixing 15ml of fumigation solution and 15ml of water each time by using a fumigation instrument, and fumigating for 25 minutes once in the morning and at night, wherein seven days are a treatment course. The operation method comprises the following steps: mixing 15ml of fumigation solution with 15ml of water, pouring into a liquid tank of a fumigator, and installing a steaming nose mask; turning on a switch, and adjusting the gear to a 1 gear; the distance between the nasal cavity of the patient and the steaming nose cover is about 5 cm, and the fumigating gas is absorbed by the nose, the mouth, the eyes, the facial skin and the like and is fumigated for 25 minutes.

1.4 evaluation method of therapeutic Effect

The clinical symptoms, signs and changes in efficacy index were recorded before treatment, at the end of treatment and 15 days after drug withdrawal, respectively. The relevant index scores are answered by parents of the sick children and recorded by the same physician.

1.4.1 Observation indicators:

1.4.1.1 clinical symptoms: the method comprises the steps of nasal obstruction symptoms, postnasal drip syndrome, cough, snoring, secretory otitis media or obstructive sleep apnea hypopnea syndrome, grading the severity of symptoms by using a grading table, and adding the grades of all symptoms to obtain the final total grade of clinical symptoms. The total score was: 0, the symptom disappears or basically disappears; 1-9 hours, the improvement is obvious; when the temperature is 10-18 hours, the improvement is achieved; when the temperature is 19-27 ℃, the effect is not obviously improved or even increased.

1.4.1.1.1 clinical chief complaint score criteria:

TABLE 1 Primary symptom score grading Scale

1.4.1.1.2 clinical secondary symptoms scoring criteria:

TABLE 2 grading and scoring criteria for degree of illness

1.4.1.2 physical sign (fiber nasopharyngoscope examination physical sign)

TABLE 3 grading and scoring criteria for physical symptoms

And (4) scoring the severity of the physical symptoms of each case by using a scoring table, and adding scores of all the physical symptoms to obtain a final total score of the physical symptoms. The total score was: 0, the symptom disappears or basically disappears; 1-6 hours, the improvement is obvious; when the temperature is 7-12 hours, the improvement is achieved; 13-18 hours, no obvious improvement or even weight increase.

1.4.1.3 curative effect index (representing the change before and after treatment by quality of life assessment (OSA-18 scale))

TABLE 4OSA-18 Scale

The score before and after treatment was integrated for each case using the scoring table, and then the score was counted, and the degree of change in the score was compared between 15 days after treatment and before treatment (nimodipine method: therapeutic efficacy index ═ integration before treatment-integration after treatment)/integration before treatment × 100%) after treatment.

1.4.2 treatment efficacy assessment criteria:

the observed clinical symptoms, physical signs and the change condition of the curative effect index are calculated according to the following treatment effect evaluation standard, and the curative effect is evaluated.

And (3) healing: clinical symptoms and physical signs disappear or basically disappear, and the curative effect index is more than or equal to 95 percent;

the effect is shown: the clinical symptoms and physical signs are obviously improved, and the curative effect index is more than or equal to 70 percent and less than 95 percent;

the method has the following advantages: the clinical symptoms and physical signs are improved, and the curative effect index is more than or equal to 30 percent and less than 70 percent;

and (4) invalidation: the clinical symptoms and physical signs are not obviously improved or even aggravated, and the curative effect index is less than 30 percent.

The total effective rate (%) - (cure + significant effect + effective) cases/group number × 100%.

Statistical methods the data counted are expressed in terms of rate (%) and statistical analysis of the data was performed using SPSS 19.0 software, with Chi for comparisons between groups ² Inspection, P<0.05 tests that the difference is statistically significant.

1.5 results

In the process of carrying out fumigation treatment by using formula comparative examples 1-2 in CN2018112303380, the skin surface of a patient is found to have erythema or eczema after 2-7 days of fumigation, and the treatment cannot be carried out. In FIG. 1, the patient in this example, male, was treated for 6 years of age. Comparative example 2 after fumigation treatment, skin allergic reaction occurred with formation of erythema accompanied by swelling and itching at 3 days of fumigation.

See table 5 for details.

TABLE 5 statistics of adverse events for control 1-2

The medicinal materials in the formula are singly extracted, and after the extracting solutions are respectively fumigated, the cucurbitacin extracting solution is found to cause adverse events such as skin erythema or eczema, and similar adverse events do not occur in the other extracting solutions.

To prepare a fumigant solution without skin side effects, the formulation was adjusted to obtain preparation examples of examples 1-2.

The results are shown in Table 6 and the adverse events are shown in Table 7.

TABLE 6 comparison of clinical efficacy of each group

The difference was statistically significant (P < 0.05).

TABLE 7 treatment group 1-2 adverse event statistics

1.6 conclusion

The traditional Chinese medicine composition and the fumigation liquid thereof provided by the invention have obvious curative effects on adenoidal hypertrophy and complications thereof, and no relapse of patients in a treatment group is observed in the follow-up process; and in the process of verifying the curative effect, no adverse reaction and toxic or side effect are found.

Claims (5)

1. A traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof is characterized by being prepared from the following traditional Chinese medicines in parts by weight:

1-1.5 parts of hairyvein agrimony, 1-1.5 parts of clematis root, 1-1.5 parts of angelica dahurica, 1-1.5 parts of folium artemisiae argyi, 1-1.5 parts of rosemary, 1-1.5 parts of centipeda minima, 1-1.5 parts of dried orange peel and 0.1-0.5 parts of mint;

the traditional Chinese medicine composition is fumigation liquid.

2. The traditional Chinese medicine composition for treating adenoidal hypertrophy and complications thereof as claimed in claim 1, wherein the traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight:

1 part of hairyvein agrimony, 1.5 parts of clematis root, 1.5 parts of angelica dahurica, 1.5 parts of folium artemisiae argyi, 1 part of rosemary, 1.5 parts of centipeda minima, 1 part of dried orange peel and 0.5 part of mint.

3. The Chinese medicinal composition for treating adenoidal hypertrophy and complications thereof as claimed in claim 1 or 2, wherein the Chinese medicinal composition is obtained by extracting the medicaments in parts by weight with water.

4. The method for preparing the Chinese medicinal composition for treating adenoid hypertrophy and complications thereof as claimed in claim 1 or 2, wherein the method comprises the steps of:

adding water in a volume ratio of 1: 5-1: 10 into the raw materials in parts by weight, soaking for 0.1-2 hours, heating, refluxing, changing into distillation after refluxing for 5-20 minutes, receiving distillate, adding water in a volume ratio of 1: 3-1: 8, continuing to distill, receiving distillate, and mixing the distillate for 2 times.

5. The use of the Chinese medicinal composition for treating adenoidal hypertrophy and complications thereof as claimed in claim 1 or 2 in the preparation of a medicament for adenoidal hypertrophy and complications thereof.

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