CN113304060B - No-clean type slow-release hydrogen peroxide sterilization hand sanitizer and preparation method thereof - Google Patents
No-clean type slow-release hydrogen peroxide sterilization hand sanitizer and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of antibacterial and bacteriostatic daily chemical articles, and particularly relates to a no-clean slow-release hydrogen peroxide sterilization hand sanitizer and a preparation method thereof. The hand sanitizer is matched with emulsifying wax, alginic acid and hydroxyl chitosan, and the film forming property and the adsorbability of the alginic acid and the hydroxyl chitosan are utilized, so that a film is easily formed after the hand sanitizer is used, hydrogen peroxide is adsorbed in the film and is slowly released, more hydrogen peroxide is prevented from contacting hands, and the sterilization durability is also ensured; the emulsified wax is used for the hand sanitizer, so that the skin is well protected, and the hand sanitizer is spread, smooth and filmed in an auxiliary way, so that an antibacterial protective oil film is formed on the skin after the hand sanitizer is used. The hand sanitizer has the advantages of simple formula materials, no need of adding a surfactant, no need of adding high-cost colloidal silver ions, environmental friendliness, no toxicity, low cost and suitability for large-scale mass production.
Description
Technical Field
The invention belongs to the technical field of antibacterial and bacteriostatic daily chemical articles, and particularly relates to a no-clean slow-release hydrogen peroxide sterilization hand sanitizer and a preparation method thereof.
Background
Along with the demand of people for health and hygiene, antibacterial and bacteriostatic products are in great demand. The hand is the most likely to be exposed to germs as a part frequently exposed to the outside. People often touch door handles, elevator buttons and the like in daily trips, and bacteria are very easy to carry. Therefore, people are required to take care of washing hands in places where the hands can be washed after shopping, riding in vehicles, going to toilets and going out, and as long as the people are in public places, a lot of bacteria exist on the hands, and if the people rub eyes, touch noses and touch faces with hands, the bacteria can quickly enter the bodies. After the person goes home, the hand is thoroughly washed clean for the first thing. The antibacterial hand sanitizer becomes a necessary daily chemical product for families.
The conventional household hand sanitizer mainly removes bacteria and dirt on hands by using water under the cleaning action of a surfactant. The hand sanitizer also contains a small amount of sterilization and antibacterial agents, but only has the function of assisting in bacteriostasis, and a large amount of bacteria are removed by cleaning and washing.
Along with the attention of people to health and the requirement of safety protection under the normal state of an epidemic situation, medical personnel, protective personnel, bus drivers and the like under the condition of outdoor work are difficult to have sufficient water to clean hands in time, so that the no-clean hand sanitizer is released. The use of the no-clean hand sanitizer lacks the step of water washing, so that bacteria need to be killed in time. Obviously, the purpose of no-clean sterilization is difficult to realize by the conventional hand sanitizer regardless of the type and the content of the bactericide.
The currently common sterilization no-clean hand sanitizer on the market is medical alcohol which has a good bacteria killing effect, the content of the common alcohol is 60-70%, the alcohol can sterilize and disinfect by matching with 2% of glycerin and propylene glycol, and the glycerin and the propylene glycol can play a role in moisturizing and skin care. However, the ethanol in the alcohol no-clean hand sanitizer is easy to volatilize, and the lasting sterilization effect is good. If the washing-free hand sanitizer needs to be sprayed again after the articles are contacted each time, great troubles are caused.
The hydrogen peroxide (hydrogen peroxide) has extremely strong killing effect on various viruses (including coronavirus, influenza virus, norovirus and the like) and has quick and efficient killing effect on various bacteria. Therefore, the sterilization and disinfection device has great significance for sterilization and disinfection in special key occasions. At present, the hydrogen peroxide has application in the aspects of cleaning, disinfection and sterilization.
Chinese invention patent CN109312265A discloses a foamable liquid cleaning composition comprising: 1 to 20 wt% of an alkoxylated C alkyl ether sulfate surfactant having 1 to 30 moles of alkylene oxide; 0.1 to 3 wt% of an amphoteric surfactant; 2 to 12 weight percent hydrogen peroxide; d) at least 65% by weight of water. Is particularly effective in removing stains from fabrics.
Chinese patent CN106214573A discloses a medical hand-free skin-care disinfectant and a preparation method thereof. The medical hand-free skin-care disinfectant takes hydrogen peroxide, tea tree oil, hyaluronic acid, mannitol, stearic acid, glycerol, triethanolamine, kasonne, p-hydroxybenzoate, medical alcohol, traditional Chinese medicine extract and the like as active ingredients, can quickly and effectively kill various bacteria and viruses between palms and finger joints, has obvious sterilization effect, is convenient to use and carry and can clean hands anytime and anywhere.
In addition, the existing no-clean hand sanitizer prepared from hydrogen peroxide and active colloidal silver ions has the sterilization rate of over 98 percent on various bacteria such as escherichia coli, staphylococcus aureus, candida albicans and the like. Most importantly, compared with alcohol, the hydrogen peroxide is stable and is not easy to volatilize, so that the bacteriostasis durability is good, and the hand can be sprayed for one time to be bacteriostatic permanently. However, the no-clean hand sanitizer prepared from hydrogen peroxide is liquid, so that the liquid is easy to run off and has influence on antibacterial persistence; on the other hand, hydrogen peroxide has strong oxidizing property and can burn after being contacted with skin for a long time.
Disclosure of Invention
The invention provides a no-clean slow-release hydrogen peroxide sterilization hand sanitizer, aiming at the problems that the no-clean hand sanitizer prepared by hydrogen peroxide is easy to run off and generates scorching heat after being in direct contact with skin for a long time, and the technical effect is that the no-clean hand sanitizer prepared by hydrogen peroxide forms a film after being coated on hands by using a film forming material and an adsorbing material, and the film has adsorbability, so that on one hand, hydrogen peroxide is adsorbed, the release of the hydrogen peroxide is slowed down, and the lasting antibacterial and bacteriostatic properties are generated; on the other hand, the formed film prevents the hydrogen peroxide from directly contacting the hands for a long time, reduces the burning feeling caused by the strong oxidation of the hydrogen peroxide and is beneficial to protecting the skin. Further provides a preparation method of the no-clean slow-release hydrogen peroxide sterilization hand sanitizer.
In order to realize the technical effects, the invention firstly provides a preparation method of a no-clean type slow-release hydrogen peroxide sterilization hand sanitizer, and the specific scheme is as follows:
(1) adding alginic acid, hydroxypropyl chitosan, citric acid and emulsifying wax into deionized water, stirring at high speed at 50-60 deg.C for dispersion, feeding into a storage tank, and naturally cooling to room temperature to obtain dispersion; the mass ratio of the alginic acid, the hydroxypropyl chitosan, the citric acid, the emulsifying wax and the deionized water is as follows: 0.1-0.2: 0.3-0.5:0.2-0.5: 0.5-0.8: 100, respectively;
(2) mixing hydrogen peroxide solution, lanolin, glycerin, propylene glycol, sorbitol, essence and the dispersion liquid obtained in the step (1) according to a mass ratio of 3-5: 0.05-0.1: 0.1-0.2: 0.05-0.1:0.05-0.1:0-0.02:100, and filling to obtain the non-washing type slow-release hydrogen peroxide sterilization hand sanitizer.
The emulsifying wax is olive oil emulsifying wax, in particular to import emulsifying wax with Olivem 1000. Emulsifying waxes have been used in cosmetic skin care products. According to the invention, the emulsifying wax is creatively used in the hand sanitizer, on one hand, the olive oil has good affinity with the skin, and can better protect the skin; on the other hand, the emulsified wax is used for assisting spreading, smoothing and film forming of the hand sanitizer so as to ensure that an antibacterial protective oil film is formed on the skin after the hand sanitizer is used.
The citric acid has weak acidity, the hand sanitizer can be maintained in a weak acid environment by using the citric acid, the stability of hydrogen peroxide in the weak acid environment is better, and the hydrogen peroxide is stable and is not easy to decompose and volatilize no matter whether the hydrogen peroxide is stored or used.
The hydrogen peroxide can be mixed with water in any proportion, the water solution of the hydrogen peroxide is weakly acidic, the hydrogen peroxide is a good broad-spectrum sterilization disinfectant, the decomposition products are water and oxygen, the environment is not polluted, and the hydrogen peroxide is a clean, environment-friendly and nontoxic sterilization disinfectant. However, when applied to a hand sanitizer, the skin may feel burning when exposed to high concentrations for extended periods of time. Therefore, on one hand, the concentration is proper when the hand sanitizer is prepared, and a hydrogen peroxide solution with the volume concentration of 27% is selected when the hand sanitizer is prepared; on the other hand, alginic acid and hydroxypropyl chitosan are used in the hand sanitizer, can adsorb and hold hydrogen peroxide, forms a film on hands, reduces the long-time high-concentration contact of the hydrogen peroxide and the hands, avoids hand burns, and has a lasting sterilization effect due to the slow release of the hydrogen peroxide.
The deionized water is distilled water obtained by boiling and sterilizing.
Preferably, the high-speed stirring dispersion process in step (1) is high-speed stirring at the rotation speed of 1200-1500rpm for 15-25 min. Aims to disperse alginic acid, hydroxyl chitosan and emulsifying wax to form dispersion liquid.
In order to improve the use comfort of the hand sanitizer, essence can be optionally added, and the essence is edible essence, such as one of lavender essential oil, rose essential oil and tea tree essential oil.
The invention further provides the no-clean slow-release hydrogen peroxide sterilization hand sanitizer prepared by the method. Aiming at the problems that the existing prepared hydrogen peroxide hand sanitizer is easy to run off to influence the antibacterial durability and is in contact with skin at high concentration for a long time to generate burning discomfort, in order to further improve the using effect of the hydrogen peroxide hand sanitizer, the invention uses emulsifying wax, alginic acid and hydroxyl chitosan in the hand sanitizer in a matching way, and makes the hand sanitizer form a film after being used easily by utilizing the film forming property and the adsorbability of the alginic acid and the hydroxyl chitosan, so that hydrogen peroxide is adsorbed in the film and released in a sustained-release manner, so that the contact of much hydrogen peroxide with hands is prevented, and the sterilization durability is also ensured; the emulsified wax is used for the hand sanitizer, so that the skin is well protected, and the hand sanitizer is spread, smooth and filmed in an auxiliary way, so that an antibacterial protective oil film is formed on the skin after the hand sanitizer is used. The hand sanitizer has the advantages of simple formula materials, no need of adding a surfactant, no need of adding high-cost colloidal silver ions, environmental friendliness, no toxicity, low cost and suitability for large-scale mass production.
The no-clean slow-release hydrogen peroxide sterilization hand sanitizer has the beneficial effects that:
1. the slow-release long-acting antibacterial and bacteriostatic effect of the hydrogen peroxide is realized by a simpler method and raw material matching, and the uncomfortable feeling of the hydrogen peroxide on hand burning is overcome.
2. The emulsified wax is used in the absorption liquid to ensure that an antibacterial protective oil film is formed on the skin after the hand sanitizer is used.
3. The no-clean hand sanitizer does not need to add a surfactant or high-cost colloidal silver ions, and is environment-friendly, non-toxic and low in cost.
Detailed Description
In order to make the technical solution of the present invention better understood, the technical solution of the present invention will be clearly and completely described below with reference to the embodiments, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments obtained by a person skilled in the art without any inventive step based on the technical idea of the present invention shall fall within the scope of protection of the present invention.
Preparation of experimental raw materials:
emulsifying wax: an italian imported emulsifying wax under the designation Olivem 1000.
Hydroxypropyl chitosan: shaanxi Saen Biotech Co., Ltd.
Hydrogen peroxide solution: a 27% strength by volume hydrogen peroxide solution.
Deionized water: sterilizing and disinfecting distilled water.
Example 1
A no-clean slow-release hydrogen peroxide sterilization hand sanitizer uses the raw material formula as shown in the table 1:
TABLE 1
(1) Adding alginic acid, hydroxypropyl chitosan, citric acid and emulsifying wax into deionized water, stirring at high speed of 1200rpm at 60 deg.C for 15min, feeding into a storage tank, and naturally cooling to room temperature to obtain dispersion;
(2) uniformly dispersing the hydrogen peroxide solution, lanolin, glycerin, propylene glycol, sorbitol, essence and the dispersion liquid obtained in the step (1), filling, installing a press type spray cap, and sealing and packaging with a plastic film to obtain the no-wash slow-release hydrogen peroxide sterilization hand sanitizer.
Example 2
A no-clean type slow-release hydrogen peroxide sterilization hand sanitizer is prepared from the following raw materials in a formula shown in a table 2:
TABLE 2
| Name of raw materials | Weight (kg) | Remarks for note |
| Alginic acid | 0.2 | Light yellow powder |
| Hydroxypropyl chitosan | 0.5 | White powder |
| Citric acid | 0.5 | Light yellow crystal powder |
| Emulsifying wax | 0.8 | White flake |
| Deionized water | 100 | |
| Hydrogen peroxide solution | 5 | |
| Lanolin | 0.1 | Paste form |
| Glycerol | 0.2 | Viscous liquid |
| Propylene glycol | 0.1 | Viscous liquid |
| Sorbitol | 0.05 | Viscous liquid |
| Rose essential oil | 0.02 |
(1) Adding alginic acid, hydroxypropyl chitosan, citric acid and emulsifying wax into deionized water, stirring at 55 deg.C and 1500rpm for 20min, feeding into a storage tank, and naturally cooling to room temperature to obtain dispersion;
(2) uniformly dispersing the hydrogen peroxide solution, lanolin, glycerin, propylene glycol, sorbitol, essence and the dispersion liquid obtained in the step (1), filling, installing a press type spray cap, and sealing and packaging with a plastic film to obtain the no-wash slow-release hydrogen peroxide sterilization hand sanitizer.
Example 3
A no-clean type slow-release hydrogen peroxide sterilization hand sanitizer is prepared from the following raw materials in a formula shown in a table 3:
TABLE 3
| Name of raw materials | Weight (kg) | Remarks for note |
| Alginic acid | 0.1 | Light yellow powder |
| Hydroxypropyl chitosan | 0.4 | White powder |
| Citric acid | 0.3 | Light yellow crystal powder |
| Emulsifying wax | 0.6 | White flake |
| Deionized water | 100 | |
| Hydrogen peroxide solution | 4 | |
| Lanolin | 0.05 | Paste form |
| Glycerol | 0.2 | Viscous liquid |
| Propylene glycol | 0.1 | Viscous liquid |
| Sorbitol | 0.05 | Viscous liquid |
| Tea tree essential oil | 0.02 |
(1) Adding alginic acid, hydroxypropyl chitosan, citric acid and emulsifying wax into deionized water, stirring at high speed of 1200rpm at 50 deg.C for 15min, feeding into a storage tank, and naturally cooling to room temperature to obtain dispersion;
(2) uniformly dispersing the hydrogen peroxide solution, lanolin, glycerin, propylene glycol, sorbitol, essence and the dispersion liquid obtained in the step (1), filling, installing a press type spray cap, and sealing and packaging with a plastic film to obtain the no-wash slow-release hydrogen peroxide sterilization hand sanitizer.
Comparative example 1
A no-clean type slow-release hydrogen peroxide sterilization hand sanitizer is prepared from the following raw materials in a formula shown in a table 4:
TABLE 4
| Name of raw materials | Weight (kg) | Remarks for note |
| Alginic acid | 0.1 | Light yellow powder |
| Hydroxypropyl chitosan | 0.3 | White powder |
| Citric acid | 0.5 | Light yellow crystal powder |
| Deionized water | 100 | |
| Hydrogen peroxide solution | 4 | |
| Lanolin | 0.08 | Paste form |
| Glycerol | 0.1 | Viscous liquid |
| Propylene glycol | 0.05 | Viscous liquid |
| Sorbitol | 0.1 | Viscous liquid |
| Rose essential oil | 0.02 |
(1) Adding alginic acid, hydroxypropyl chitosan and citric acid into deionized water, stirring at high speed of 1200rpm at 60 deg.C for 15min, feeding into a storage tank, and naturally cooling to room temperature to obtain dispersion;
(2) uniformly dispersing the hydrogen peroxide solution, lanolin, glycerin, propylene glycol, sorbitol, essence and the dispersion liquid obtained in the step (1), filling, installing a press type spray cap, and sealing and packaging with a plastic film to obtain the no-wash slow-release hydrogen peroxide sterilization hand sanitizer.
Comparative example 1 no emulsifying wax was added during the formulation of the hand sanitizer, the resulting hand sanitizer did not form an oil film well, lacked protection of the oil film, and there was some skin burn with long-term use of hydrogen peroxide.
Comparative example 2
A no-clean type slow-release hydrogen peroxide sterilization hand sanitizer is prepared from the following raw materials in a formula shown in a table 5:
TABLE 5
(1) Adding alginic acid, citric acid and emulsifying wax into deionized water, stirring at high speed of 1200rpm at 60 deg.C for 15min, feeding into a storage tank, and naturally cooling to room temperature to obtain dispersion;
(2) uniformly dispersing the hydrogen peroxide solution, lanolin, glycerin, propylene glycol, sorbitol, essence and the dispersion liquid obtained in the step (1), filling, installing a press type spray cap, and sealing and packaging with a plastic film to obtain the no-wash slow-release hydrogen peroxide sterilization hand sanitizer.
Comparative example 2 hydroxypropyl chitosan was not added when preparing the hand sanitizer, the obtained hand sanitizer had poor film-forming phase when used, had reduced holdability for hydrogen peroxide, had poor long-acting antibacterial and bacteriostatic effects of slow-release hydrogen peroxide, and had burning sensation on hands.
Comparative example 3
A no-clean type slow-release hydrogen peroxide sterilization hand sanitizer is prepared from the following raw materials in a formula shown in a table 6:
TABLE 6
(1) Adding alginic acid, hydroxypropyl chitosan, citric acid and emulsifying wax into deionized water, stirring at high speed of 1200rpm at 60 deg.C for 15min, feeding into a storage tank, and naturally cooling to room temperature to obtain dispersion;
(2) uniformly dispersing the hydrogen peroxide solution, lanolin, glycerin, propylene glycol, sorbitol, essence and the dispersion liquid obtained in the step (1), filling, installing a press type spray cap, and sealing and packaging with a plastic film to obtain the no-wash slow-release hydrogen peroxide sterilization hand sanitizer.
Comparative example 3 citric acid was not added when the hand sanitizer was formulated, the pH of the resulting hand sanitizer was high, and hydrogen peroxide in the formulated hand sanitizer was easily decomposed during storage and use, resulting in a certain reduction in the bactericidal effect.
And (3) relevant experimental tests:
basic service performance test:
testing the pH value by using an acidity pen; kinematic viscosity was measured using a rotational viscometer as shown in table 7.
TABLE 7
Through tests, the hand sanitizer obtained by the invention is weakly acidic, has certain viscosity, cannot block materials during pressing type spraying, is uniformly sprayed, and meets the use requirements. Comparative example 1 no emulsifying wax was added when preparing the hand sanitizer, and the resulting hand sanitizer had a certain burning sensation on the skin after use depending on the user's reaction due to the lack of protection of the oil film and the inability to form an oil film well. Comparative example 2 hydroxypropyl chitosan was not added when preparing the hand sanitizer, the resulting hand sanitizer had poor film-forming phase properties when used, had reduced holdability for hydrogen peroxide, and had burning sensation on the hands.
(2) And (3) testing the sterilizing effect:
cultivating Escherichia coli (ATCC8099) bacterial liquid with the concentration of 1000 cfu/ml; soaking No. 1-7 filter paper in the Escherichia coli solution for 30s, taking out, and naturally drying for 1 h; then, the hand sanitizer obtained in examples 1-3 and comparative examples 1-3 is sprayed on the filter paper with bacteria, wherein No. 7 is not sprayed with the hand sanitizer and is used as a comparison sample; and testing the sterilization effect 10min after spraying. The number of cells in 7# was large, and the sterilization efficiency was determined as a control, and the sterilization efficiency (V) of the hand cleanser in example 1 was (number of cells in 7# minus 1# cells)/number of cells in 7# cells. The test results are shown in Table 8.
The concentration of the culture liquid of staphylococcus aureus (ATCC6538) is 200 cfu/ml; soaking 8-14# filter paper in the golden yellow grape bacterial liquid for 30s, and naturally drying for 1h after taking out; then, the hand sanitizer obtained in examples 1-3 and comparative examples 1-3 is sprayed on the filter paper with bacteria, wherein No. 14 is not sprayed with the hand sanitizer and is used as a comparison sample; and testing the sterilization effect 10min after spraying. The test results are shown in Table 8.
TABLE 8
(3) And (3) testing the continuous antibacterial effect:
the filter paper 1-14# sample sprayed with the hand sanitizer tested above was left to stand for 6 hours naturally, and the sterilization efficiency was tested again. As shown in table 9.
TABLE 9
Through tests on the sterilizing effect and the lasting sterilization of the hand sanitizer, the obtained hand sanitizer has excellent sterilizing effect in the initial use stage, and can continuously inhibit the propagation of bacteria and kill the bacteria continuously with the passage of time. The sterilization method is based on the reason that hydrogen peroxide in the hand sanitizer is adsorbed by soldiers and chitosan to form a film and gradually and slowly sterilize. Comparative example 1 no emulsifying wax was added when the hand sanitizer was formulated, the slow release of hydrogen peroxide was slightly poor, but bacteria were inhibited due to the hydroxypropyl chitosan holding and releasing hydrogen peroxide; comparative example 2 hydroxypropyl chitosan is not added when the hand sanitizer is prepared, the obtained hand sanitizer has poor film-forming phase property when in use, the holdability to hydrogen peroxide is reduced, and the long-acting antibacterial and bacteriostatic effect of the slow-release hydrogen peroxide is poor; comparative example 3 citric acid was not added when the hand sanitizer was formulated, the pH of the resulting hand sanitizer was high, and hydrogen peroxide in the formulated hand sanitizer decomposed during storage, resulting in a reduction in initial bactericidal effect.
Claims (4)
1. A no-clean type slow-release hydrogen peroxide sterilization hand sanitizer is prepared by the following method:
(1) adding alginic acid, hydroxypropyl chitosan, citric acid and emulsifying wax into deionized water, stirring at high speed at 50-60 deg.C for dispersion, feeding into a storage tank, and naturally cooling to room temperature to obtain dispersion; the mass ratio of the alginic acid to the hydroxypropyl chitosan to the citric acid to the emulsifying wax to the deionized water is as follows: 0.1-0.2: 0.3-0.5:0.2-0.5: 0.5-0.8: 100, respectively;
(2) mixing hydrogen peroxide solution, lanolin, glycerin, propylene glycol, sorbitol and essence with the dispersion liquid obtained in the step (1) according to a mass ratio of 3-5: 0.05-0.1: 0.1-0.2: 0.05-0.1:0.05-0.1:0-0.02:100, uniformly dispersing and filling to obtain the no-clean slow-release hydrogen peroxide sterilization hand sanitizer; the hydrogen peroxide solution is 27% by volume.
2. The no-clean slow-release hydrogen peroxide sterilization hand sanitizer according to claim 1, characterized in that: the emulsifying wax is olive oil emulsifying wax.
3. The no-clean slow-release hydrogen peroxide sterilization hand sanitizer according to claim 1, characterized in that: the deionized water is distilled water obtained by boiling and sterilizing.
4. The no-clean slow-release hydrogen peroxide sterilization hand sanitizer according to claim 1, characterized in that: the preferred high speed stirring and dispersing process is high speed stirring at the rotation speed of 1200-1500rpm for 15-25 min.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105581930A (en) * | 2014-10-24 | 2016-05-18 | 邵杰 | A green efficient sterilizing disinfectant |
| CN105832581A (en) * | 2016-05-13 | 2016-08-10 | 马鞍山纽盟知识产权管理服务有限公司 | Novel no-wash hand sanitizer for children |
| CN111228304A (en) * | 2020-03-11 | 2020-06-05 | 山东名德医疗科技有限公司 | Virus-killing hand-washing-free disinfectant and preparation method thereof |
| CN111529550A (en) * | 2020-04-29 | 2020-08-14 | 江苏斯微特医药科技有限公司 | Preparation method of polysaccharide quick-drying hand disinfectant |
| CN111742925A (en) * | 2020-07-03 | 2020-10-09 | 湖南凯斯利新材料有限公司 | Environment-friendly long-acting washing-free sterilizing disinfectant and preparation and use methods thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| BRPI0920914A8 (en) * | 2008-11-20 | 2017-10-03 | Chata Biosystems Inc | ALPHA-KETO PERACIDS AND METHODS FOR PRODUCING AND USING THEM. |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105581930A (en) * | 2014-10-24 | 2016-05-18 | 邵杰 | A green efficient sterilizing disinfectant |
| CN105832581A (en) * | 2016-05-13 | 2016-08-10 | 马鞍山纽盟知识产权管理服务有限公司 | Novel no-wash hand sanitizer for children |
| CN111228304A (en) * | 2020-03-11 | 2020-06-05 | 山东名德医疗科技有限公司 | Virus-killing hand-washing-free disinfectant and preparation method thereof |
| CN111529550A (en) * | 2020-04-29 | 2020-08-14 | 江苏斯微特医药科技有限公司 | Preparation method of polysaccharide quick-drying hand disinfectant |
| CN111742925A (en) * | 2020-07-03 | 2020-10-09 | 湖南凯斯利新材料有限公司 | Environment-friendly long-acting washing-free sterilizing disinfectant and preparation and use methods thereof |
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