CN102894001A - Antiseptic and mildew inhibitor composition for wet tissues and production method thereof - Google Patents

Abstract

The invention relates to an antiseptic and antifungal agent composition for wet wipes and a production method thereof. The composition is composed of water solvent of antiseptic, antifungal agent, quick bactericide, solvent and auxiliary agent. The preparation method is to dissolve the preservative and deionized water to prepare the water solvent of the preservative, dissolve the antifungal agent in the solvent, add the rapid bactericide, stir and dissolve, then add the auxiliary agent, and finally add the antiseptic The water solvent of the agent is stirred, mixed and filtered to obtain the antiseptic and antifungal agent composition for wet wipes. The invention has the advantages of reasonable formula, advanced technology, simple operation and easy realization of large-scale production, and the product has good anti-corrosion and anti-mildew effects when applied to wet wipes.

Description

A kind of anticorrosion and antifungal agent composition for wet wipes and production method thereof

technical field

The invention belongs to the technical field of preparation of chemical antiseptic and antifungal agents, and relates to an antiseptic and antifungal agent composition for wet wipes and a production method thereof.

Background technique

With the continuous improvement of people's living standards, people's consumption of wet wipes is also increasing, and there are more and more varieties of wet wipes. From hotel wet towels, car wipes, makeup remover wipes, mask wipes to children's hygiene wipes, etc., the production scale of wet wipes has also expanded from manual workshops to automatic production lines. As far as the many occasions and functions of wet wipes are concerned, wet wipe manufacturers are all required to strictly disinfect wet wipes during the manufacturing process of wet wipes, and at the same time have a good anti-corrosion and anti-mold effect during storage. .

According to the current materials, the types of wet wipes are usually divided into four types: one is chemical fiber non-woven fabric, the second is pure cotton cloth, the third is chemical fiber/cotton blended fabric, and the fourth is all wood pulp paper cloth. Chemical fiber non-woven wet wipes are relatively easy to breed bacteria and not easy to grow mold. Pure cotton wet wipes are more likely to breed bacteria and mold. Chemical fiber/cotton blended or wood pulp paper wet wipes are basically the same as pure The same happens with cotton.

According to the national "Hygienic Standards for Disposable Hygienic Products" (GB15979-2002) on the hygienic indicators of wet wipes, the appearance of disposable wet wipes (wet towels) should be neat and tidy, and the products must not have abnormal odors and foreign objects. Produce adverse irritation, allergic reactions and other damage to the skin and mucous membranes; its microbiological indicators are: the total number of bacterial colonies in disposable wet towels ≤ 200cfu/g, coliforms and pathogenic suppurative bacteria cannot be detected, and the total number of fungal colonies ≤100cfu/g; the total bacterial colony of disposable sanitary wipes ≤20cfu/g, coliforms, pathogenic suppurative bacteria and fungi shall not be detected.

This standard is very demanding, and it is difficult to achieve without a good production environment and a good anti-corrosion and anti-mildew system. Although wet wipes are disinfection products, their process does not include disinfection. Once they are contaminated during production, storage, and transportation, many harmful microorganisms will be attached to the wet wipes. After consumers use contaminated wet towels, it can cause diarrhea and skin diseases in mild cases, and may cause other diseases in severe cases.

The current production process of wet wipes is basically divided into five steps, namely, 1) preparation: preservatives, essences, water, skin care agents, etc. are prepared in proportion, and if it is a hygienic wet towel, disinfectants need to be added; 2) stirring: Mix the prepared liquid evenly; 3) Soaking: soak the dry towel or dry towel in the liquid for a certain period of time; 4) Drain: Drain the wet towel to the specified weight; 5) Packing: fold the wet towel into it The bag is sealed. If it is continuous production, the prepared liquid is sprayed on the towel body, and then packaged.

If the wet wipes are placed in a humid, stuffy, and unventilated warehouse for a long time, especially during the rainy season, the appropriate temperature and humidity will cause a large number of fungi to multiply. When you open the packaging bag, you can see black or dark green or purple stains on the white wet wipes. Or yellow mold stains with an unpleasant musty smell.

Due to the difficulty in anti-corrosion and anti-mildew of wet wipes, in the past, many domestic wet wipe manufacturers have suffered a lot of losses due to the serious exceeding of microorganisms in wet wipes, odor and mildew. In order to prevent the reproduction of microorganisms on wet wipes, many companies use the method of adding preservatives to the preparation solution to ensure that the products meet the national hygiene standards during the shelf life. However, since our country currently does not specify the type and amount of preservatives added to wet wipes, some companies often use various preservatives arbitrarily or increase the concentration of preservatives in order to ensure that the microbial indicators of wet wipes meet the requirements. Although it has been controlled, the hidden hazards are a great threat to the health of consumers, especially some preservatives that are highly toxic and irritating to the skin often cause skin allergies or other discomforts on the user's face. For example, the antiseptic glutaraldehyde used by many enterprises, as a high-efficiency disinfectant, can achieve the sterilization effect at a concentration of 2% glutaraldehyde, but glutaraldehyde has strong irritation to the skin and mucous membranes, and it can Absorbed by the body through the skin, long-term exposure can cause cancer. In cosmetics and skin and mucous membrane disinfectants, the state clearly stipulates that the concentration of glutaraldehyde should not exceed 0.1%, and when the concentration of glutaraldehyde in cosmetics exceeds 0.05%, glutaraldehyde must be marked on the label, but the survey found that no The glutaraldehyde added by wet wipe manufacturers to their products is far more than 0.1%. In daily behavior, most people will not wash their hands after using wet wipes, so chemical components such as preservatives will remain on their faces and hands. If you use wet wipes containing more glutaraldehyde to wipe your face, it may cause skin allergies and contact dermatitis, and if it directly contacts the eyes, it may even cause serious consequences of cornea and vision damage.

In addition to glutaraldehyde, the preservative system currently used by wet wipe manufacturers also includes Kathon (Kathon, Kathon). This preservative has a broad spectrum of sterilization and has a bactericidal effect on bacteria and molds. It has no effect on bacterial spores, poor killing effect on pseudomonas, poor stability, strong skin irritation, and easy to cause antiseptic failure when used alone.

In addition, some domestic wet wipe manufacturers use biguanide and quaternary ammonium salt preservatives. Strictly speaking, cations are fungicides that are quick to sterilize but have no long-lasting antiseptic function. They can be stored for a short time when used alone in chemical fiber wet wipes, but they cannot have the proper antiseptic effect on cotton or cotton-containing wet wipes.

In the Chinese patent text whose publication number is CN101416843A, a kind of production method of smoke-proof and dust-proof wet towel has been disclosed. , Polyhexamethylene biguanide, distilled water and mint liquid are mixed to form a solution; 2. High-temperature disinfection of selected towels; 3. Soak the sterilized towels in a well-proportioned solvent and take them out; 4. Put the removed towels into aluminized film packaging bags for sterile sealing. In this patent, bis-imidazolidinyl urea is used as one of the antiseptic components, which will release formaldehyde. At the same time, several preservatives need to be added separately, which is very inconvenient to use. It is difficult to dissolve iodopropynyl butyl carbamate even in propylene glycol. , It takes a long time for stirring and dissolving. At the same time, the pre-treatment of towels requires high-temperature disinfection, which consumes energy and increases the production process. In the Chinese patent text whose publication number is CN102613935A, a kind of aromatic disinfectant wet tissue and its preparation method are once disclosed. Sodium borate and essence are made into a disinfectant mixed solution, and then the disinfected mixed solution is dripped and wetted on the carrier paper towel, and the dripping amount is 1.5 milliliters per gram of paper towel, and the paper towel is wet to obtain an aromatic disinfectant wet wipe; the method uses tetrahydrate Sodium octaborate is used as a preservative component. This is a commonly used wood preservative, but it cannot be used in wet wipe products that come into contact with the human body. There is no sodium octaborate tetrahydrate in the 56 preservatives specified in the "2007 Cosmetic Technical Specifications" , and various antiseptic ingredients are added separately, which is extremely inconvenient. In addition, the publication number is CN102177901A Chinese patent text once announced a kind of bactericidal preservative composition containing benzethonium chloride and its application, it consists of benzethonium chloride accounting for 1-50% of the total composition, 0.5-10 % antifungal agent, 5-30% synergist, and 10-80% solvent, the composition contains a large amount of expensive phenoxyethanol, ethylhexylglycerin, etc., poor economic feasibility, and cations are limited Strong, it will interact with anions and lose its bactericidal function.

Contents of the invention

The object of the present invention is to solve the problems existing in the prior art, and to provide an antiseptic and antifungal agent composition for wet wipes with reasonable formula, advanced technology and good antiseptic and antimold effect and its production method.

In order to achieve the purpose of the above invention, on the basis of a large number of formula tests, combined with extensive microbial challenge tests, synergistic research on anti-corrosion and anti-mold components and long-term production and application practices, an original wet Antiseptic and antifungal agent composition for towels, the active ingredients of the antiseptic and antifungal agent composition for wet wipes are prepared from the following material raw materials in percentage by weight:

Wherein, said preservative is 2-methylisothiazolinone (MIT) and/or 5-chloro-2-methylisothiazolinone (CMIT) and/or bronopol (Bropol), It is fused with deionized water at a ratio of 10% to 50%: 50% to 90% to form a water solvent for preservatives. The antifungal agent is 3-iodo-2 propargyl butyl carbamate ( IPBC) and/or parabens, said rapid bactericide is p-chlorodimethylphenol (PCMX) and/or 2,4-dichloro-3,5-dimethylphenol (DCMX), said The solvent is 1,2 propylene glycol and/or glycerin and/or ethylene glycol and/or dipropylene glycol, and the auxiliary agent is hydrogenated castor oil and/or nonylphenol polyoxyethylene ether (TX-10) and/or fat Alcohol polyoxyethylene ether (AEO-9) and/or sodium lauryl ether sulfate and/or alkyl glycoside (APG), said stabilizer is sodium nitrate and/or lithium nitrate and/or potassium nitrate and/or Or benzoyl peroxide.

The preferred weight percent scope of the material raw material that makes wet tissue of the present invention is used antisepsis and antifungal agent composition is:

The technical solution of the present invention also is: said preservative is 2-methylisothiazolinone (MIT) and/or 5-chloro-2-methylisothiazolinone (CMIT), and it and deionized water According to the ratio of 10% to 50%: 50% to 90%, the water solvent that constitutes the preservative is dissolved. The antifungal agent is 3-iodo-2 propargyl butyl carbamate (IPBC). The rapid bactericide is p-chlorodimethylphenol (PCMX), said solvent is dipropylene glycol, and said auxiliary agent is fatty alcohol polyoxyethylene ether (AEO-9) and/or alkyl glycoside (APG), More preferred auxiliary agent is alkyl glycoside (APG), and said stabilizer is sodium nitrate and benzoyl peroxide.

The method for preparing the antiseptic and antifungal agent composition for wet wipes comprises the following processing steps:

1. Dissolve the preservative in deionized water, quickly neutralize it with alkali until the pH is 2-4, adjust the weight content of the preservative in the water solvent to 10%-50% to obtain the water solvent of the preservative, and add a stabilizer Stir well, filter and set aside;

2. Dissolve the antifungal agent in the solvent, then add the rapid bactericide and stir to dissolve, then add the auxiliary agent and stir well to obtain the antifungal and bactericidal solution;

3. Add the preservative water solvent obtained in step 1 under the condition of stirring the anti-mold and sterilizing solution after step 2, stir and mix evenly, and then filter.

The technical solution of the production method of the present invention is also: said preservative is 2-methylisothiazolinone (MIT) and 5-chloro-2-methylisothiazolinone (CMIT), the weight of both The mixing ratio is 1:2~4.

The technical solution of the production method of the present invention is also: said stabilizing agent is sodium nitrate and benzoyl peroxide, and said fungicide is 3-iodo-2 propargyl butyl carbamate, so Said solvent is dipropylene glycol, said rapid bactericide is p-chlorodimethylphenol, and said auxiliary agent is alkyl glycoside.

The beneficial effects of the present invention are as follows.

1. In view of the defects of high toxicity of preservatives in the prior art, high cost of use, and cumbersome addition operations, the present invention selects the antiseptic and antifungal agent components that can be used as stipulated in the national "2007 Cosmetics Technical Specifications" to form a broad-spectrum antiseptic and antifungal agent Composition, using 5-chloro-2-methyl-4-isothiazolin-3-one, 2-methyl-4-isothiazolin-3-one, bronopol, etc., which are cost-effective and highly effective in sterilization and antiseptic At the same time, it is combined with the most excellent high-efficiency fungicide IPBC (3-iodo-2 propargyl butyl carbamate), paraben, etc. in the daily chemical industry at the same time, and it is assisted to quickly kill the harmful Microbial p-chlorodimethylphenol (PCMX), scientifically combines the effects of sterilization, antiseptic and anti-mold through the above compatibility, and adding it alone can protect the wet wipes from being contaminated by microorganisms, thus making the product more powerful Anti-corrosion and anti-mildew effect, forming the best composition against microbial hazards, can exert the best anti-corrosion, anti-mold, skin protection and skin care effects, and also bring great convenience to wet wipe manufacturers.

2. The antiseptic system of the present invention contains moisturizing ingredients, which improves the use efficiency of wet wipes.

3. The anti-corrosion and anti-mold components used in the present invention have low toxicity and are all within the listed range of preservatives for cosmetics. They have high safety and can be added at one time alone to effectively prevent the drug resistance of microorganisms to preservatives.

4. The antiseptic and antifungal agent composition for wet wipes of the present invention has good stability, and the normal temperature storage period is greater than 12 months.

5. The present invention uses composite anti-corrosion and anti-mold components. According to the antibacterial spectrum of the relevant preservatives, the synergistic effect of complementary advantages between various components takes into account both rapid sterilization and long-term antibacterial efficacy, and at the same time relatively reduces the amount of preservatives in wet wipes. The dosage reduces toxicity and irritation.

6. The production method of the antiseptic and antifungal agent composition for wet wipes of the present invention is simple in operation and easy to realize large-scale production.

The anti-corrosion and anti-mildew agent composition for wet wipes of the present invention has good stability. After the product was stored at room temperature for one year, the anti-corrosion and anti-mold test effect test for wet wipes was carried out, and the situation is as follows.

The anti-corrosion and anti-mildew agent composition for wet wipes of the present invention has very good anti-corrosion and anti-mold effects when applied to wet wipes. In the actual test, 0.2 parts of antiseptic and antifungal agent compositions for wet wipes of the present invention, 0.5 parts of aloe extract, 0.1 parts of essence and 99.2 parts of deionized water were stirred and mixed, and the dry towels were continuously soaked in the liquid for a certain period of time (15 ~30 minutes), drained to the specified weight, folded wet towels, put them into packaging bags and sealed them, and kept them at a constant temperature of 28°C for 28 days. During this period, the number of colonies on the wet wipes was regularly checked. The test results are shown in Table 1. The results show that: the antiseptic and anti-mold agent composition for wet wipes of the present invention has excellent anti-corrosion and anti-mold effects, while the blank wet towels have peculiar smell after 3 days, and then mildew spots appear on the surface of the wet towels.

Table 1 Anticorrosion and mildew prevention effect of antiseptic and antimold agent composition for wet wipes of the present invention

The antiseptic and antifungal agent composition for wet wipes of the present invention has also been used in nutrient-enriched wet wipe soaking liquid to pass the microbial challenge test. The formula (mass fraction) of the soaking solution is as follows: 1.0 of the aloe extract, 1.2 of proline, 0.2 of hyaluronic acid, and 97.5 of deionized water; Mix the above materials evenly, add mixed bacteria and mixed fungi (Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Aspergillus niger, Candida albicans), culture at a constant temperature of 37°C for 28 days, and regularly test the microbial content. The results are shown in Table 2.

Table 2 Microbiological challenge test results of nutrient-rich wet wipes

Detailed ways

Example 1

Weigh the 5-chloro-2-methyl-4-isothiazoline-3-ketone/2-methyl-4-isothiazoline-3-ketone/2-methyl-4-isothiazoline-3-one obtained after cyclization of thiopropionamide (with halogen or sulfuryl chloride as cyclization agent). 20 kilograms of 3-ketone (CMIT/MIT) hydrochloride, the weight ratio of CMIT/MIT is 3/1, dissolves in 70 kilograms of deionized water, neutralizes the solution to pH 2～4 with sodium bicarbonate, uses Deionized water is replenished to a total amount of 100 kilograms to obtain 5-chloro-2-methyl-4-isothiazolin-3-one/2-methyl-4-isothiazolin-3-one preservative without divalent ion protection Add 4 kilograms of stabilizers consisting of sodium nitrate and benzoyl peroxide (sodium nitrate and benzoyl peroxide are 3.5 kilograms and 0.5 kilograms respectively) and stir evenly, standby; Get 75 kilograms of dipropylene glycol, add IPBC5 1 kg to dissolve; then add 3 kg of PCMX to dissolve, and finally add 2 kg of non-ionic surfactant APG and stir evenly; add 5-chloro-2-methyl-4-isothiazolin-3-one/ 15 kg of water solvent of 2-methyl-4-isothiazolin-3-one preservative, dispersed and stirred for 30 minutes, filtered with 100-mesh stainless steel mesh to obtain the inventive product.

Example 2

Weigh 20 kg of CMIT/MIT hydrochloride, the weight ratio of CMIT/MIT is 4/1, dissolve in 70 kg of deionized water, neutralize the solution to pH 2-4 with sodium bicarbonate, replenish with deionized water To a total amount of 100 kg, the water solvent of 5-chloro-2-methyl-4-isothiazolin-3-one/2-methyl-4-isothiazolin-3-one preservative without divalent ion protection , add 3 kg of stabilizer (sodium nitrate and benzoyl peroxide are 2.5 kg and 0.5 kg respectively), and set aside; take 75 kg of dipropylene glycol, add 4 kg of IPBC to dissolve; add 4 kg of PCMX to dissolve, and finally add 2 kg of non Stir the ionic surfactant APG; add 5-chloro-2-methyl-4-isothiazolin-3-one/2-methyl-4-isothiazolin-3-one preservative without divalent ion protection under stirring 15 kilograms of water solvents, dispersed and stirred for 30 minutes, filtered with 100 mesh stainless steel mesh to obtain the invention product.

Example 3

Weigh 6 kg of 2-methyl-4-isothiazolin-3-one (MIT) hydrochloride preservative and dissolve it in 5 kg of deionized water, neutralize the solution to pH 2 to 4 with sodium bicarbonate, and use Make up the total amount of ionized water to 12 kg for later use; take 75 kg of 1,2 propylene glycol, add 5 kg of IPBC to dissolve; then add 5 kg of PCMX to dissolve, and finally add 3 kg of non-ionic surfactant APG and stir well. Under stirring, add 12 kilograms of water solvents of the above-mentioned standby preservatives, disperse and stir for 30 minutes, and filter with 100 mesh stainless steel mesh to obtain the inventive product.

Example 4

Weigh 7 kg of MIT hydrochloride preservative and dissolve it in 4 kg of deionized water, neutralize the solution with sodium bicarbonate to a pH of 2 to 4, make up to 12 kg with deionized water, and then add 3 kg of bromine Nitrol, dissolved to obtain 15 kg of preservative water solvent, set aside; take 75 kg of 1,2 propylene glycol, add 5 kg of IPBC to dissolve; add 3 kg of PCMX to dissolve, and finally add 2 kg of non-ionic surfactant APG and stir well. Under stirring, add 15 kilograms of the above-mentioned water solvent of standby preservative, disperse and stir for 30 minutes, and filter with 100 mesh stainless steel mesh to obtain the inventive product.

Claims (7)

1. wet tissue Antisepticize and mildew preventive composition, the active ingredient that it is characterized in that said composition is prepared from by the raw material of substance of following weight percentage:

Said preservative is 2-methylisothiazolinone and/or 5-chloro-2-methyl isothiazolinone and/or bronopol, itself and deionized water are in 10%～50%: the fused aqueous solvent that consists of preservative of 50%～90% ratio, said mould inhibitor is 3-iodo-2 propargyl butyl carbamates and/or nipagin esters, said quick sterilization agent is to Chlorodimethyl phenol and/or 2,4-two chloro-3, the 5-xylenol, said solvent is 1,2 propane diols and/or glycerine and/or ethylene glycol and/or dipropylene glycol, said auxiliary agent is rilanit special and/or polyoxyethylene nonylphenol ether and/or fatty alcohol-polyoxyethylene ether and/or sodium lauryl tri(oxyethyl) sulfate and/or alkyl glycoside, and said stabilizing agent is sodium nitrate and/or lithium nitrate and/or potassium nitrate and/or benzoyl peroxide.

2. wet tissue according to claim 1 Antisepticize and mildew preventive composition, the active ingredient that it is characterized in that said composition is prepared from by the raw material of substance of following weight percentage:

3. wet tissue according to claim 1 Antisepticize and mildew preventive composition, it is characterized in that said preservative is 2-methylisothiazolinone and/or 5-chloro-2-methyl isothiazolinone, itself and deionized water are in 10%～50%: the fused aqueous solvent that consists of preservative of 50%～90% ratio, said mould inhibitor is 3-iodo-2 propargyl butyl carbamates, said quick sterilization agent is to Chlorodimethyl phenol, said solvent is dipropylene glycol, said auxiliary agent is fatty alcohol-polyoxyethylene ether and/or alkyl glycoside, and said stabilizing agent is sodium nitrate and benzoyl peroxide.

4. according to claim 1 or 3 described wet tissue Antisepticize and mildew preventive compositions, it is characterized in that said auxiliary agent is alkyl glycoside.

One kind for the production of claim 1 or 2 described wet tissues with the method for Antisepticize and mildew preventive compositions, it is characterized in that comprising following processing step:

5.1 preservative is dissolved in the deionized water, be 2～4 with the alkali pH that neutralizes rapidly, adjusting preservative weight content in aqueous solvent is 10%～50%, gets the aqueous solvent of preservative, adds stabilizing agent and stirs, and filters stand-by;

5.2 mould inhibitor is dissolved in the solvent, then add quick sterilization agent stirring and dissolving, add again auxiliary agent and stir evenly, obtain antimycotic antiseptic solution;

5.3 in the aqueous solvent of the preservative that adding step 5.1 obtains under the condition that the antimycotic antiseptic solution after the step 5.2 is stirred, mix, filtration gets final product.

6. production method according to claim 5 is characterized in that said preservative is 2-methylisothiazolinone and 5-chloro-2-methyl isothiazolinone, and the weight mixing ratio of the two is 1: 2～4.

7. production method according to claim 5, it is characterized in that said stabilizing agent is sodium nitrate and benzoyl peroxide, said mould inhibitor is 3-iodo-2 propargyl butyl carbamates, said solvent is dipropylene glycol, said quick sterilization agent is to Chlorodimethyl phenol, and said auxiliary agent is alkyl glycoside.