CN113198105A - Random bionic micro-texture brain deep stimulation sleeve electrode with roughened surface - Google Patents
Random bionic micro-texture brain deep stimulation sleeve electrode with roughened surface Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/02—Details
- A61N1/04—Electrodes
- A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
- A61N1/0526—Head electrodes
- A61N1/0529—Electrodes for brain stimulation
- A61N1/0534—Electrodes for deep brain stimulation
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Abstract
本发明公开了一种表面毛化的随机仿生微织构脑深部刺激套管电极，其圆柱外表面具有仿生微织构，所述仿生微织构由一系列凹坑组成，所述凹坑的形状大小随机生成，所述凹坑的位于套管电极上的位置随机产生，所述凹坑为形状不规则的盲孔，凹坑之间随机的相互叠加，相互叠加的凹坑连通形成毛细管。本发明的有益效果：套管电极具有表面毛化的随机仿生微织构，不但不影响其原有的导向功能，还能储存脑脊液、减小套管电极与脑组织的有效摩擦面积，减小穿刺摩擦力，并且可减小穿刺过程中脑组织的变形程度；表面毛化形成的凹坑微结构随机相互重叠连通形成毛细管，利用毛细管作用更易于捕捉润滑剂，降低套管电极对脑组织的穿刺损伤。
The invention discloses a surface-textured random biomimetic micro-textured deep brain stimulation sleeve electrode. Its cylindrical outer surface has a biomimetic micro-texture, and the bio-mimetic micro-texture is composed of a series of pits. The shape and size are randomly generated, the positions of the pits on the sleeve electrode are randomly generated, the pits are blind holes with irregular shapes, the pits are randomly superimposed on each other, and the superimposed pits are connected to form capillaries. Beneficial effects of the invention: the cannula electrode has a random bionic micro-texture textured on the surface, which not only does not affect its original guiding function, but can also store cerebrospinal fluid, reduce the effective friction area between the cannula electrode and the brain tissue, and reduce the The puncture friction force can reduce the degree of deformation of the brain tissue during the puncture process; the microstructures of the pits formed by the surface texture are randomly overlapped and connected to each other to form capillaries, and the capillary action is used to capture the lubricant more easily, reducing the effect of the cannula electrode on the brain tissue. Puncture injury.
Description
Technical Field
The invention belongs to the technical field of deep brain stimulation and puncture intervention, and particularly relates to a random bionic microtextured deep brain stimulation sleeve electrode with a roughened surface.
Background
With the aggravation of the aging problem of the population and the increase of the living and working pressure of human beings, more and more patients present deep brain diseases, which cause dysfunction of some nerve nuclei in the deep brain, and the diseases are manifested as a series of mental activity disorders such as behavior, will, cognition, emotion and the like, and seriously affect the physical and mental health of human beings.
Deep brain stimulation is an effective way to treat such disorders. In the operation process, the sleeve electrode punctures brain tissue in a longer path so as to realize the positioning of the needle point of the stimulating electrode to a target point, and the length of the puncture path is generally more than 50 mm. When the sleeve electrode pierces the cerebral cortex and enters the brain tissue, the cylindrical surface of the sleeve electrode and the brain tissue will generate puncture friction force due to relative movement. The puncture friction force can be increased along with the increase of the puncture depth, and the brain tissue can be continuously sheared, dragged and pulled in the puncture path besides being deformed and displaced, so that the brain tissue in the puncture path can be injured by edema, scars, glia, apoptosis and the like. In addition, the frontal cerebral cortex is the most important nervous tissue area in the brain, and during the needle insertion and needle withdrawal of the cannula electrode, the frontal cerebral cortex always has friction with the cylindrical surface of the cannula electrode. The frictional damage to the frontal lobe is greatest relative to other locations.
Therefore, the friction force between the cylindrical surface of the sleeve electrode and the brain tissue is reduced, the puncture injury of the sleeve electrode to the brain tissue is effectively reduced, and the satisfactory treatment effect and fewer complications of deep brain stimulation can be further obtained.
The applicant is dedicated to the research of the sleeve electrode, and previously filed an invention patent with application number 202010065753.6 and named as a linear staggered array bionic microtextured brain deep stimulation sleeve electrode. This patent has announced that the surface has the sleeve electrode of bionical little texture, and little texture slot can store the cerebrospinal fluid, has lubricated effect, the certain frictional force that has reduced between sleeve electrode cylindrical surface and the brain tissue. Because the microtexture is regularly distributed in a staggered array, the slender edge of the microtexture groove has a continuous cutting effect on the brain tissue, and the brain tissue can be damaged in severe cases.
Disclosure of Invention
Aiming at the problems that in the prior art, the friction force between the sleeve electrode and the brain tissue is large, and the brain tissue can be damaged in the puncture process, the random bionic microtexture brain deep stimulation sleeve electrode with the roughened surface is provided.
A random bionic micro-texture brain deep stimulation sleeve electrode with a roughened surface is characterized in that the outer cylindrical surface of the sleeve electrode is provided with a bionic micro-texture, and the bionic micro-texture is composed of a series of pits.
Wherein the shape and size of the pits are randomly generated.
Wherein the location of the pits on the casing electrode is randomly generated.
Wherein the diameter of the pits is randomly distributed between 10 and 20 mu m.
Wherein the depth of the pits is randomly distributed between 10 and 20 mu m.
The bionic micro-texture is distributed at the front end position on the outer cylindrical surface of the sleeve electrode within the length range of 60 mm.
Wherein, the pit is a blind hole with an irregular shape.
Wherein, the pits are mutually overlapped at random, and the mutually overlapped pits are communicated to form a capillary tube.
Wherein the pits are distributed on the cylindrical surface of the sleeve electrode in a positive offset state.
The invention has the beneficial effects that:
1. the sleeve electrode has a roughened random bionic microtexture, so that the original guiding function of the sleeve electrode is not influenced, cerebrospinal fluid can be stored, the effective friction area between the sleeve electrode and brain tissue is reduced, the puncture friction force is reduced, and the deformation degree of the brain tissue in the puncture process can be reduced;
2. the pit microstructures formed by surface texturing are overlapped and communicated with each other randomly to form capillaries, so that a lubricant can be captured easily by utilizing the capillary action, the puncture friction force is reduced by utilizing the characteristic of dynamic pressure lubrication, the puncture damage of the cannula electrode to brain tissue is reduced, and the deformation degree of the brain tissue in the puncture process can be reduced;
3. the method for processing the bionic microtexture on the cylindrical surface of the sleeve electrode is utilized, other materials are not doped, and the biocompatibility of the sleeve electrode can be ensured.
Drawings
FIG. 1 is a topographical view of a sleeve electrode in accordance with an embodiment of the present invention;
FIG. 2 is a distribution diagram of random bionic microtexture of surface texturing on a deep brain stimulation sleeve electrode according to an embodiment of the invention;
FIG. 3 is a schematic diagram of the processing of the random biomimetic microtextured deep brain stimulating sleeve electrode with roughened surface according to the embodiment of the present invention;
FIG. 4 shows the translational position of the sleeve electrode relative to the tool electrode during the micro electric discharge surface texturing process according to the embodiment of the present invention.
Detailed Description
In order to make the technical problems solved, the technical solutions adopted and the technical effects achieved by the present invention clearer, the technical solutions of the present invention are further described below by way of specific embodiments with reference to the accompanying drawings. It is to be understood that the specific embodiments described herein are merely illustrative of the invention and are not limiting of the invention. It should be further noted that, for the convenience of description, only some but not all of the elements associated with the present invention are shown in the drawings.
Referring to fig. 1-4, this example provides a random biomimetic microtextured deep brain stimulation sleeve electrode with a textured surface.
As shown in fig. 1 and 2, the parameters of the sleeve electrode, such as material, length, outer circle and inner hole diameter, are the same as those of the sleeve electrode with a smooth surface clinically. The sleeve electrode is a stainless steel hollow cylinder of phi 1.5mm, with a wall thickness of about 150 μm and a length of about 130 mm. Wherein the total length of the microtextured area is about 60mm and the distance from the front end face of the electrode is 0.5mm, so as to prevent the microtexture from having an inserting effect on brain tissue when puncture is started.
The casing electrode is prepared by utilizing the principle of random superposition of pit microstructures obtained after the surface of the electrode is subjected to texturing treatment by utilizing a micro electric spark discharge grinding technology. The shape of the bionic microtexture on the cylindrical surface of the sleeve electrode is a single pit microstructure or a shape formed by randomly superposing a plurality of pit microstructures after micro electric spark discharge texturing; microscopically, the positions of the single bionic microtexture on the cylindrical surface of the sleeve electrode are randomly distributed, the depth, the shape and the size are random, and the mutual intervals are random. Macroscopically, the total length of the micro-texture area on the cylindrical surface of the sleeve electrode is 60mm, and the distance from the front end face of the electrode is 0.5mm, so that the micro-texture can be prevented from having an inserting effect on brain tissues when puncture is started; the whole microtextured area is full of pit microstructures after micro electric spark discharge, and the microtexture has the characteristic of isotropic distribution.
The microtexture composition comprises a plurality of rows of pits with different sizes, and the pits are blind holes. The pits have a diameter of 10 to 20 μm and a depth of 10 to 20 μm. The size of the pits is randomly generated, and the diameter and the depth of the pits are randomly distributed in the range.
The pits are irregular in shape, are not regular round blind holes, and the openings of the pits are not necessarily regular round. Its diameter is the largest dimension of the opening and its depth is the distance of the deepest point.
The pits are mutually overlapped, and are distributed on the surface of the sleeve electrode in a positive offset state.
The concave pit can store cerebrospinal fluid, reduce the effective friction area of the sleeve electrode and brain tissue, and reduce the puncture injury of the sleeve electrode to the brain tissue.
The pits are mutually overlapped and communicated to form capillaries with different shapes and randomly distributed. The lubricant is easier to capture through the capillary action, the puncture friction force is reduced by utilizing the characteristic of dynamic pressure lubrication, and the puncture damage of the sleeve electrode to brain tissue is reduced.
Because the capillary has different shapes and randomly distributed length positions, the cutting effect on brain tissues in the puncture process can be effectively avoided.
The sleeve electrode is a stainless steel hollow cylinder of phi 1.5mm and has a wall thickness of about 150 μm. Therefore, the bionic microtexture with the depth of tens of microns or less does not influence the puncture guiding performance of the cannula. The brain nerve cells are not distributed in discrete particles and are tightly connected with each other, so that the diameter of the bionic microtexture is equal to or less than the size level (10-20 mu m) of the brain nerve cells, and the brain nerve cells can be prevented from entering the bionic microtexture.
Researches show that the non-smooth biological surface with a certain shape has obvious antifriction effect, such as: a mosquito blood sucking nose device with bristles and an ovipositor with unsmooth parasites, which can obviously reduce the puncture resistance.
As shown in figures 3 and 4, according to the preparation method of the sleeve electrode, the random bionic microtexture on the cylindrical surface of the brain deep stimulation sleeve electrode can be subjected to texturing processing by a micro electric spark discharge grinding technology.
Step 1, placing the sleeve electrode with a smooth surface in alcohol to perform ultrasonic cleaning twice, wherein each cleaning is performed for 10min to remove impurities on the surface. After the cleaning is finished, placing the paper on clean paper absorption paper, and naturally drying the paper in the air;
step 2, clamping the sleeve electrode with a smooth surface by a three-jaw chuck of a hollow rotary clamp holder, and installing the sleeve electrode on a micro electric spark machining machine tool, wherein the external elongation is more than 65 mm;
step 4, mounting the cuboid metal block with a smooth surface on a workbench of a micro electric discharge machine tool as a tool electrode, and adjusting the position and the spatial posture of the cuboid metal block to enable the plane of the cuboid metal block to be parallel to the axis of the sleeve electrode with a smooth surface and the distance to be not more than 2 mm;
step 6, adjusting the axial positions of the sleeve electrode and the cuboid metal block to enable the overlapping length to be equal to the length of an expected micro-textured area;
step 7, setting electrical parameters of micro electric spark machining texturing, the rotating speed of the hollow rotary clamper and the spraying speed of cooling liquid;
step 8, adjusting the distance between the sleeve electrode and the cuboid metal block to enable the sleeve electrode to reach a reasonable discharge gap;
and 9, slowly moving the position of the sleeve electrode relative to the cuboid metal block along the direction vertical to the axis in the discharge plane to compensate the discharge consumption of the tool electrode.
And step 10, randomly superposing the pit microstructures obtained after the surface of the sleeve electrode is subjected to the texturing treatment along with the micro electric spark discharge grinding process to finish the preparation of the random bionic microtexture for stimulating the surface of the sleeve electrode to be textured in the deep part of the brain.
As shown in fig. 3, the rotating spindle head 2 is provided with three-grip chucks for holding the sleeve electrode 1. The rotary spindle head 2 can be rotated rapidly. And the lifting device 5 can move up and down while rotating. The lifting device 5 may be a ball screw mechanism driven by a servo motor and cooperating with a rail slider mechanism.
As shown in fig. 3, the tool electrode 3 is provided on the table 4. The tool electrode 3 is a rectangular parallelepiped metal block. The workbench 4 can drive the tool electrode 3 to translate along two directions of an x axis and a y axis so as to control the distance between the tool electrode 3 and the sleeve electrode 1, and can also translate during the electric spark machining.
The material surface is subjected to micro electric spark discharge texturing treatment, so that micron-sized high-frequency melting and gasification can be generated on the material in a texturing area, and a large number of positive polarization pit microstructures which are randomly distributed and mutually overlapped can be formed on the texturing treatment surface.
The tool electrode is a cuboid metal block with a flat surface in the micro electric spark discharge grinding process, the plane of the cuboid metal block is parallel to the axis of the sleeve electrode, and the height of the cuboid metal block is less than or equal to the total length of the micro-textured area; the tool electrode is charged negatively (positively), and the sleeve electrode is charged positively (negatively). The gap between the two is adjustable, so that an ideal surface texturing discharge gap is obtained; the sleeve electrode rotates at a constant speed to meet the random discharge texturing treatment in the circumferential direction; the sleeve electrode is axially translatable relative to the tool electrode to satisfy random discharge texturing across the microtextured areas in the axial direction.
In the description of the present invention, it should be noted that the terms "upper", "lower", "left", "right", "clockwise" and "counterclockwise" and the like indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus, should not be construed as limiting the present invention.
The foregoing embodiments are merely illustrative of the principles and features of this invention, which is not limited to the above-described embodiments, but rather is susceptible to various changes and modifications without departing from the spirit and scope of the invention, which changes and modifications are within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (9)
1. A random bionic micro-texture brain deep stimulation sleeve electrode with a roughened surface is characterized in that the outer surface of a cylinder of the random bionic micro-texture brain deep stimulation sleeve electrode is provided with a bionic micro-texture, and the bionic micro-texture is composed of a series of pits.
2. The surface-textured random biomimetic microtextured deep brain stimulation sleeve electrode according to claim 1, wherein the shape and size of the pits are randomly generated.
3. The surface-textured random biomimetic microtextured deep brain stimulation sleeve electrode according to claim 1, wherein the locations of the pits on the sleeve electrode are randomly generated.
4. The surface-textured random biomimetic microtextured deep brain stimulation sleeve electrode according to claim 1, wherein the diameter of the pits is randomly distributed between 10 μm and 20 μm.
5. The surface-textured random biomimetic microtextured deep brain stimulation sleeve electrode according to claim 1, wherein the depths of the pits are randomly distributed between 10 μ ι η and 20 μ ι η.
6. The surface-roughened random biomimetic microtextured deep brain stimulation cannula electrode according to claim 1, wherein the biomimetic microtexture is distributed at a front position on an outer cylindrical surface of the cannula electrode, within a length range of 60mm in total.
7. The surface-roughened random biomimetic microtextured deep brain stimulation sleeve electrode according to claim 1, wherein the dimples are irregularly shaped blind holes.
8. The surface-roughened random biomimetic microtextured brain deep stimulating sleeve electrode according to claim 1, wherein the pits are randomly stacked one on top of another, the stacked pits being communicated to form a capillary.
9. The surface-textured random biomimetic microtextured deep brain stimulation sleeve electrode according to claim 1, wherein the dimples are distributed in a positive polarization on the cylindrical surface of the sleeve electrode.
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| CN202110620544.8A CN113198105A (en) | 2021-06-03 | 2021-06-03 | Random bionic micro-texture brain deep stimulation sleeve electrode with roughened surface |
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| CN202110620544.8A CN113198105A (en) | 2021-06-03 | 2021-06-03 | Random bionic micro-texture brain deep stimulation sleeve electrode with roughened surface |
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| CN104783842A (en) * | 2015-04-10 | 2015-07-22 | 山东大学 | Novel anti-drag surface texture biopsy needle |
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2021
- 2021-06-03 CN CN202110620544.8A patent/CN113198105A/en active Pending
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105194796A (en) * | 2009-06-09 | 2015-12-30 | 神经毫微股份公司 | Microelectrode and multiple microelectrodes comprising means for releasing drugs into the tissue |
| US20120053645A1 (en) * | 2010-08-31 | 2012-03-01 | Boston Scientific Neuromodulation Corporation | Systems and methods for making and using enhanced electrodes for electrical stimulation systems |
| CN102988100A (en) * | 2012-11-09 | 2013-03-27 | 大连理工大学 | Low-resistance acupuncture method |
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| CN106110447A (en) * | 2016-07-19 | 2016-11-16 | 西安培华学院 | A kind of new medical painless syringe syringe needle |
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