CN113194908B

CN113194908B - Kit for caring skin

Info

Publication number: CN113194908B
Application number: CN201880100560.0A
Authority: CN
Inventors: 许令玮; 冶玉花; 于鲲; 闫志鹏
Original assignee: LOreal SA
Current assignee: LOreal SA
Priority date: 2018-12-29
Filing date: 2018-12-29
Publication date: 2024-01-16
Anticipated expiration: 2038-12-29
Also published as: CN113194908A; CN115192473A; WO2020133361A1; CN115192473B

Abstract

A kit, comprising: (1) A first composition comprising at least one water-insoluble multivalent metal salt and at least one water-soluble polyhydroxy polymer, and (2) a second composition comprising at least one aqueous phase, and a) optionally, at least one water-soluble multivalent metal ion chelating agent, and b) at least one water-soluble gelling agent that forms a gel with multivalent metal ions. The kit can be used for caring keratin materials, in particular skin, for managing skin wounds, for preventing post-operative adhesion formation or for filling or repairing osteochondral defects.

Description

Kit for caring skin

Technical Field

The present invention relates to an alginic system, in particular to an alginic suit for caring skin. The invention also relates to the use thereof, in particular as a mask for caring for keratin materials, in particular the skin.

Background

The ultimate goal in the cosmetic field has always been to provide consumers with efficient products with skin benefits such as hydration, moisturization, whitening, cleansing, etc.

Among all compositions for caring for keratin materials, in particular the skin, masks are known to have a high osmotic efficacy for keratin materials. Therefore, two-digit market growth of facial mask cosmetics is seen in China.

There are generally four types of masks, namely, cream-type, peel-off type, gel-type, and wet wipe-type masks. Among them, the cream type and the peel-off type facial films are mainly used for cleansing keratin materials, and the gel type and the wet towel type facial films are more commonly used for skin care. It is known that gel type masks have good adhesion to the skin and can provide good freshness, but may not sufficiently deliver moisturizing or hydrating effects to the skin, whereas wet tissue type masks are good at delivering moisturizing and hydrating effects, but can be withdrawn if applied for a long period of time. Furthermore, the adhesion to the skin may not be as good as the gel profile.

Meanwhile, for a mask, particularly a facial tissue type mask, it is desirable that the mask applied to the face is soft to bring about better touch feeling and better skin fit.

Based on the foregoing, there is a need for a new mask that combines two or more of the advantages exhibited by known mask types, but that does not have one or more of the problems associated therewith.

Object of the Invention

Thus, in one aspect, it is desirable to provide a facial mask that is capable of undergoing a texture transition, such as from a tissue to a gel, to provide a pleasant consumer experience.

In another aspect, it is desirable to provide a facial mask that has at least comparable or even greater moisture or active delivery capacity than that observed with wet wipe facial masks.

In another aspect, it is necessary to provide a mask which has good adhesion to the skin and can provide a fresh feeling just like a gel-type mask.

In another aspect, it is desirable to provide a facial mask that can deliver a moisturizing effect or active to keratin materials for a long period of time and that does not retract the effect, thereby exhibiting further improvements such as hydration effects compared to wet wipe facial masks.

In another aspect, it is desirable to provide a mask that is significantly effective in improving fine wrinkles.

In another aspect, it is necessary to provide a mask that combines all of the benefits described in the above aspects.

In another aspect, the inventors have found that the concepts or principles of the present invention are applicable not only to the cosmetic field, but also to other fields, such as the medical field, and thus the mask of the above aspect may be broadened to suit (kits), which also exhibit the benefits described herein with respect to these masks.

DISCLOSURE OF THE INVENTION

The inventors have found that one particular combination may meet one or more of the above requirements, said combination comprising: 1) A first composition comprising at least one water-insoluble multivalent metal salt as an ion donor for multivalent metal, and at least one water-soluble polyhydroxy polymer; and 2) a second composition comprising at least one aqueous phase, and a) optionally, at least one water-soluble multivalent metal ion chelating agent, and b) at least one water-soluble gelling agent that forms a gel with multivalent metal ions.

One subject of the present invention is thus a kit comprising a first composition and a second composition placed separately from each other.

Another subject of the invention is a mask pack 1 comprising: 1) A first composition comprising at least one water insoluble multivalent metal salt, at least one hydroxyl-rich fiber and at least one water soluble polyhydroxy polymer, and 2) a fourth composition comprising at least one aqueous phase, and b) at least one water soluble gelling agent that forms a gel with multivalent metal ions; wherein the first composition and the fourth composition are placed apart from each other.

Another subject of the invention is the use of a second composition as a juice (tool) or part of a juice of a mask product comprising, separately from the second composition, a fabric (or towel) comprising at least one water-insoluble multivalent metal salt according to the invention.

A further subject of the invention is the use of the kit according to the invention for caring for keratin materials, in particular the skin. Such use may be represented by a method of caring for keratin materials, in particular the skin, comprising the step of compounding, in a predetermined weight ratio, the first composition and the second composition of the kit, and then applying the mixture thus obtained to the keratin materials.

A further subject of the invention is the use of a kit according to the invention for managing skin wounds, for preventing post-operative adhesion formation or for filling or repairing osteochondral defects and the like. Such use may be manifested as a method of managing skin wounds, preventing post-operative adhesion formation or filling or repairing osteochondral defects, comprising the steps of compounding the first and second compositions of the kit in a predetermined weight ratio, and then applying to a site where the mixture thus obtained is desired.

Other features and advantages of the present invention will become more apparent upon reading the following specification and examples.

Detailed Description

Except in the operating examples, or where otherwise indicated, all numbers expressing amounts of ingredients and/or reaction conditions are to be understood as being modified in all instances by the term "about", meaning within 10% of the indicated number (e.g., "about 10%" means 9% -11%, and about "2%" means 1.8% -2.2%).

The articles "a" and "an" as used herein mean one or more when applied to any feature in embodiments of the invention described in the specification and claims. The use of "a" and "an" does not limit the meaning to a single feature unless such a limit is specifically indicated. The article "the" preceding singular or plural nouns or noun phrases refers to a particular specified feature or features and may have singular or plural connotations depending upon the context in which it is used. The adjective "any" means one, some, or all, with no distinction between amounts.

The term "comprising" (and grammatical variants thereof) as used herein is used in the inclusive sense of "having" or "comprising," and not in the exclusive sense of "consisting only of …. Nevertheless, the skilled artisan will certainly appreciate that for embodiments capable of being implemented in the form of "comprising," forms "consisting essentially of …" and "consisting of …" are naturally modifications of this embodiment and are also within the scope of the invention.

All percentages and ratios are by weight unless otherwise indicated. All percentages are based on the total weight of the composition, unless otherwise indicated. The content of all components or compositions refers to the active content of the component or composition and excludes impurities, such as residual solvents or byproducts, which may be present in commercial sources.

Preferably, the "keratin material" according to the invention is skin. "skin" means whole body skin. Still preferably, the keratin material is the face or neck, especially the face.

By "topical application" is meant that the composition is applied or spread onto a surface of a keratin material, such as at least one region of the skin.

By "rinse-off" is meant a composition that is rinsed from the skin after a predetermined period of time has elapsed, such as the removal of water from the skin.

"alkali metal" means an element located in group IA of the periodic table, such as sodium, potassium, lithium, or a combination thereof, preferably sodium, potassium, or a combination thereof.

The term "water-soluble or water-dispersible" refers to a compound which, when introduced into water at 25 ℃ at a mass concentration equal to 1%, gives a macroscopically homogeneous and transparent solution, i.e. a solution having a maximum light transmission through a 1 cm thick sample of at least 60%, preferably at least 70%, at a wavelength equal to 500 nm.

In this application, unless explicitly mentioned otherwise, the amounts, parts and percentages are by weight.

According to the invention, the kit comprises a first composition and a second composition.

First composition

First, the first composition according to the present invention comprises at least one water-insoluble multivalent metal salt and at least one water-soluble polyhydroxy polymer.

Water insoluble multivalent metal salts

The term "water insoluble" means that the salt is insoluble in water, e.g. has a solubility of less than 0.01g/100g water, or only slightly soluble in water, e.g. has a solubility of less than 0.5g/100g water, and does not disintegrate into a bulk state when immersed in water.

In particular, the at least one water-insoluble multivalent metal salt may be present in the form of a powder, a microparticle, a fiber or a bulk state.

For the purposes of the present invention, the term "particulate" when used with respect to a water insoluble multivalent metal salt means that the salt is in particulate form.

In particular, the water insoluble multivalent metal salt may be formed from an acid anion and a multivalent metal cation, especially calcium, strontium, zinc, copper, manganese, aluminum, or mixtures thereof. The metal that can be used is preferably calcium, copper or a mixture thereof, more preferably calcium.

The acid providing the acid anion according to the present invention may be any known acid that can be used in cosmetics, as long as the salt formed by the acid and the polyvalent metal is water-insoluble or slightly soluble. Typical acids that may be used include various inorganic acids such as sulfuric acid, carbonic acid, phosphoric acid, metaaluminate, silicic acid, and various organic acids, especially highly saturated or unsaturated fatty acids, especially those having 18 or more carbon atoms, such as stearic acid and oleic acid, or polycarboxylic acids, especially such as alginic acid, oxalic acid, as long as the salts formed are water insoluble or sparingly soluble.

More specifically, the at least one water-insoluble multivalent metal salt may be a sulfate or alginate, preferably selected from calcium sulfate/calcium alginate, strontium sulfate/strontium alginate, zinc sulfate/zinc alginate, copper sulfate/copper alginate, manganese sulfate/manganese alginate or mixtures thereof, preferably calcium sulfate/calcium alginate or copper sulfate/copper alginate, in particular calcium sulfate/calcium alginate.

The term "alginate" particularly refers to salts of alginic acid. Alginic acid-a natural substance obtained from brown algae or from certain bacteria, is composed of two uronic acids linked together via a 1, 4-glycosidic bond: a polyuronic acid comprising beta-D-mannuronic acid (M) and alpha-L-glucuronic acid (G).

Wherein the primary cationWater-insoluble alginates containing calcium are found especially in Phaeophyceae @Phaeophyceae) In the leaf and stem of seaweed, an example of this seaweed is Fucus vesiculosus @Fucus vesiculosus) Spiral Fucus vesiculosusFucus spiralis) Algae with leaf soaking functionAscophyllum nodosum) Giant kelpMacrocystis pyrifera) Algae with wingAlaria esculenta）、Eclonia maximaThe light black giant seaweedLessonia nigrescens）、Lessonia trabeculataSea-tangleLaminaria japonica) Radix seu herba Heterophyllae AnnuaeDurvillea antarctica) Kelp in northLaminaria hyperborea) Brown algae with long-stranded algaeLaminaria longicruris) Kelp in palm shapeLaminaria digitata) Sea tangle with sugarLaminaria saccharina) Kelp of Ke's diseaseLaminaria cloustoni) AndSaragassum sp.。

suitable water insoluble alginates have a weight average molecular weight of from about 20,000 daltons to about 500,000 daltons. As in Martinsen et al, "Comparison of Different Methods for Determination of Molecular Weights and Molecular Weight Distribution of Alginates" (carbohydrate. Polym., 15, 171-193, 1991), the intrinsic viscosity is first determined and then the weight average molecular weight is calculated using the Mark-Houwink Sakurada equation.

Water-soluble polyhydroxy polymers

The term "polyhydroxy polymer" refers to a hydroxyl-containing nonionic polysaccharide.

The inventors have surprisingly found that hydroxyl-rich polymers can soften fibers, especially when the fibers are also hydroxyl-rich. By hydroxyl-rich fibers is meant herein fibers having at least 2 hydroxyl groups, preferably at least 3 hydroxyl groups, per repeat unit of the polymer of the fiber and having at least one hydroxyl-containing side chain, wherein less than 60%, preferably less than 30% or preferably less than 15% of the hydroxyl groups in the side chain are substituted.

Useful water-soluble polyhydroxy polymers include polyhydroxy carboxylic acids, acid esters; polyhydroxy cellulose; etc.

Some celluloses are known to be useful in promoting gelling behavior. Accordingly, polyhydroxy cellulose is preferably available.

In particular, nonionic polyhydroxycellulose ethers are particularly preferred, among which hydroxyalkyl celluloses, such as hydroxymethyl cellulose, hydroxyethyl cellulose (HEC) and hydroxypropyl cellulose (HPC), can be mentioned; and mixed hydroxyalkyl alkyl celluloses such as hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose, and hydroxybutyl methylcellulose.

According to one embodiment, the first composition of the invention may comprise the at least one water-soluble polyhydroxy polymer in an amount of from 0.001% to 1% by weight, in particular from 0.01% to 0.1% by weight, such as from 0.01% to 0.06% by weight, relative to the total weight of the first composition.

Super absorbent material (Superabsorbent material)

According to one embodiment of the invention, the first composition may comprise at least one superabsorbent material.

In particular, the at least one superabsorbent material may be present in the form of powder, particles, fibres or in bulk state.

Superabsorbent materials advantageously exhibit a very high capacity to absorb liquids, in particular water. In particular, it may exhibit a capacity to absorb 15 times, or even 20 to 50 times, such as about 25 to 30 times, the weight of its own water.

The liquid absorption capacity of a superabsorbent material can be determined by performing the following method.

Samples of superabsorbent material in powder, fibrous or bulk state or arranged as films or sheets are weighed in the dry state (M _D ). For example, square nonwoven webs having sides of about 1 centimeter (cm) can be used. In the context of the present process, the superabsorbent material is obtained in the "dry" state by treatment in a drying oven at about 50 ℃ for about 4 hours (h).

Water (or any other liquid to be absorbed by the material) is brought into contact with the material. This can be done by immersing the material in a liquid or by pouring a liquid onto the material. For example, the material may be soaked for a duration of about 1 minute (min).

Excess water (or liquid) is used, for example, to completely saturate the material. Excess water (or liquid) is then removed, for example by dripping for about 2 minutes, and the liquid-saturated material is weighed (M _L ）。

The difference delta between the weight of the material when saturated with liquid and the weight of the material when dry represents the amount of liquid that the material has absorbed, which weight is compared to the dry weight of the material. The value C obtained indicates the capacity of the superabsorbent material to absorb liquid, for example expressed in grams of liquid absorbed per gram of dry material:

。

the superabsorbent material may be selected from cellulose derivatives, alginates (excluding water-insoluble alginates and alkali metal alginic acid compounds described herein as water-soluble gelling agents) and derivatives thereof, in particular derivatives such as propylene glycol alginate or salts thereof, derivatives of polyacrylic or polymethacrylic acid, derivatives of poly (meth) acrylamide, derivatives of polyvinylpyrrolidone, derivatives of polyvinyl ether, mixtures thereof and the like.

In particular, the superabsorbent material may be selected from derivatives of chemically modified cellulose. For example, it may be selected from carboxymethyl cellulose, sodium carboxymethyl cellulose, carboxymethyl hydroxyethyl cellulose, carboxyethyl cellulose, hydroxyethyl ethyl cellulose, hydroxypropyl methyl cellulose, sodium methyl cellulose, microcrystalline cellulose, sodium cellulose sulfate, and mixtures thereof.

It may also be selected from alkyl celluloses. These polymers are obtained by grafting alkyl residues onto one or more hydroxyl groups of a cellulose polymer to form a hydroxyalkyl derivative. These alkyl residues may be selected from the following groups: stearyl, isostearyl, lauryl, myristyl, cetyl, isocetyl, cocoyl, palmityl, oleyl, linonyl, ricinoleyl (ricinolyl), behenyl, and mixtures thereof. These hydroxyalkyl cellulose derivatives may also be chemically modified, for example using carboxylic acid residues (carboxylic residue).

The superabsorbent materials may also be selected from natural polymer derivatives, such as gellan gum and glucomannan and galactomannan polysaccharides extracted from seeds, plant fibers, fruits, seaweed, starch, plant resins or even microbial sources. For example, it may be selected from agar gum (agar gum), guar gum, tragacanth gum, carrageenan, konjac gum, locust bean gum, gellan gum, xanthan gum and mixtures thereof.

In particular, the first composition of the invention may comprise said at least one superabsorbent material in a content of from 0% to 80% by weight, in particular from 50% to 80% by weight, or even the remaining amount (the rest), relative to the total weight of the first composition.

According to one embodiment of the invention, especially for facial mask applications, the first composition further comprises further fibers in addition to the fibers formed from the at least one water insoluble multivalent metal salt, wherein the at least one water insoluble multivalent metal salt and the at least one water soluble polyhydroxy polymer are loaded onto the further fibers.

For example, according to embodiment 1, the water-insoluble multivalent metal salt may be present in the form of fibers. The fibers of the at least one water-insoluble multivalent metal salt may then be formed into a water-insoluble substrate, either alone or with one or more other fibers. The water-soluble polyhydroxy polymer was loaded onto the substrate.

Alternatively, according to embodiment 2, the water-insoluble multivalent metal salt and the water-soluble polyhydroxy polymer may each be uniformly distributed in the water-insoluble substrate.

Water insoluble substrate

For the purposes of the present invention, the term "water-insoluble" means that the substrate is insoluble in water and does not disintegrate when immersed in water.

Embodiment 1:

generally, in this embodiment 1, the substrate may be a woven fabric or a nonwoven fabric made of fibers of the at least one water-insoluble polyvalent metal salt (hereinafter also referred to as water-insoluble polyvalent metal salt fibers) together with at least one other fiber selected from natural fibers such as cotton, pulp, bamboo and cellulose fibers, semi-natural fibers such as viscose rayon fibers, synthetic fibers such as polyester fibers, polyethylene terephthalate fibers, polyethylene fibers and polypropylene fibers. Two or more selected from other fibers may be used in combination.

The inventors have surprisingly found that hydroxyl-rich fibers can be easily softened with water-soluble polyhydroxy polymers. Thus, hydroxyl-rich fibers are preferably used according to the present invention. Such fibers may be regenerated cellulose or cotton fibers. Examples of hydroxyl-rich fibers include Viscose (Viscose), modal (Modal), lyocell (Lyocell), cupro (Cupro), cotton (Cotton), and the like.

The substrate may be formed in a wide variety of shapes and forms, such as flat pads, thick pads, sheets of irregular thickness, depending on the desired use and characteristics of the kit. By way of example only, in the case of a mask, the substrate is typically designed to conform to the area of skin where topical application is desired. For this purpose, the substrate is designed to correspond to the shape of the face, optionally avoiding the eyes, nostrils and mouth areas, when the mask is applied to the face. Non-limiting examples of substrates that can be used in the present invention are described, for example, in patent application WO 02/062132 or EP 2489286A.

According to embodiment 1, the water-insoluble multivalent metal salt is preferably formed from organic acids, especially highly saturated or unsaturated fatty acids, especially those having 18 or more carbon atoms, such as stearic acid and oleic acid, or polycarboxylic acids, such as alginic acid, oxalic acid, among others.

In particular, the water-insoluble substrate or fabric may comprise water-insoluble multivalent metal salt fibers, especially calcium alginate fibers, in an amount of 10 to 80 wt.%, especially 10 to 40 wt.%, relative to the total weight of the water-insoluble substrate or fabric. Accordingly, the water-insoluble substrate or fabric may comprise the at least one other fiber in an amount of 10 to 80 wt%, especially 50 to 80 wt%, relative to the total weight of the water-insoluble substrate or fabric.

More particularly, suitable nonwoven fabrics comprising calcium alginate fibers are commercially available from Sanjiang corporation under the name M762R-40 CN.

Embodiment 2:

alternatively, according to embodiment 2, the substrate may comprise a woven or nonwoven fabric consisting essentially of fibers selected from the group consisting of natural fibers, such as cotton, pulp, bamboo, and cellulose fibers; semi-natural fibers such as viscose rayon fibers; synthetic fibers such as at least one of polyester fibers, polyethylene terephthalate fibers, polyethylene fibers and polypropylene fibers. For such substrates, the at least one water-insoluble multivalent metal salt is distributed as uniformly as possible in the substrate.

Accordingly, water-insoluble multivalent metal salts are prepared as aqueous dispersions, for example for water-insoluble calcium salts. The dispersion is then applied to the substrate, for example, by coating, spraying, or the like, whereby the calcium salt is uniformly distributed in the substrate in an amount sufficient to form a gel with the alginate on the substrate. The wet substrate loaded with aqueous salt (aquous salt) is then dried. The method of drying the tissue is not particularly limited. For industrial applications, the wet substrate is dried in a cost effective manner.

According to another embodiment, the water-insoluble multivalent metal salt, such as a calcium salt, in solid form, e.g. as a water-insoluble salt, is crushed into a powder or particles, e.g. by milling, grinding or the like. The powder or particles are then applied uniformly to the substrate. The diameter of the powder or particles is not particularly limited as long as the water-insoluble multivalent metal salt can be uniformly distributed in the substrate in an amount sufficient to form a gel with the alginate on the substrate.

According to embodiment 2, the water-insoluble multivalent metal salt is preferably formed from an inorganic acid, for example one selected from sulfonic acid, carbonic acid, phosphoric acid, metaaluminate, silicic acid, preferably sulfonic acid.

According to embodiment 2, the water-insoluble substrate or fabric may comprise water-insoluble multivalent metal salts, in particular calcium salts, in an amount of 0.01 to 5 wt%, preferably 0.02 to 1 wt% or preferably 0.04 to 0.5 wt%, relative to the total weight of the water-insoluble substrate or fabric.

Method for bonding polyhydroxy polymers to substrates

In order to provide a softened substrate, the water soluble polyhydroxy polymer is preferably combined with a water insoluble substrate. The method of bonding the water-soluble polyhydroxy polymer to the water-insoluble substrate is not particularly limited, as long as the water-soluble polyhydroxy polymer can be uniformly distributed in the substrate in an amount sufficient to soften the substrate to a desired degree.

According to one embodiment, the water-soluble polyhydroxy polymer is prepared as an aqueous solution. The water-soluble polyhydroxy polymer was then loaded onto a substrate, such as facial tissue.

According to another embodiment, the water-soluble polyhydroxy polymer is prepared as a suspension or paste, for example, the water-soluble polyhydroxy polymer is suspended in or mixed with a non-aqueous medium to form a suspension or paste thereof. The suspension or paste is then applied to the substrate, such as by coating, spraying, or the like, so that the water-soluble polyhydroxy polymer is uniformly distributed in the substrate in an amount sufficient to form a gel with the alginate on the substrate.

In the case of applying the water-soluble polyhydroxy polymer using an aqueous solution, suspension or paste, the wet substrate loaded with the aqueous salt (aquous salt) is then dried. The method of drying the tissue is not particularly limited. For industrial applications, the wet substrate is dried in a cost effective manner.

According to yet another embodiment, the water-soluble polyhydroxy polymer in solid form is crushed into a powder or particle, such as by milling, grinding, or the like. The powder or particles are then applied uniformly to the substrate. The diameter of the powder or particles is not particularly limited as long as the water-soluble polyhydroxy polymer can be uniformly distributed in the substrate in an amount sufficient to soften the substrate.

According to the invention, the water-insoluble substrate or fabric may comprise the water-soluble polyhydroxy polymer, such as HEC or HPC, in an amount of from 0.001% to 1% by weight, especially from 0.01% to 0.1% by weight, such as from 0.01% to 0.06% by weight, relative to the total weight of the water-insoluble substrate or fabric.

The kit according to the invention comprises a second composition separate and apart from the first composition (e.g. the water insoluble substrate). The second composition is impregnated, coated or otherwise contacted with the first composition as desired to change the texture of the first composition, for example from a tissue to a gel.

Preferably, the weight ratio of the first composition (e.g., water insoluble substrate or fabric) to the second composition is from 1:3 to 1:20, preferably from 1:8 to 1:15, in order for a sufficient texture transition to occur.

Second composition

The second composition of the present invention comprises at least a) optionally, at least one water-soluble multivalent metal ion chelating agent and b) at least one water-soluble gelling agent which forms a gel with multivalent metal ions.

According to the present invention, when the first composition is mixed with the second composition, the water-insoluble multivalent metal ion donor reacts with the salt in the solution and releases multivalent metal ions. When the second composition does not comprise component a), the at least one water-soluble multivalent metal ion chelating agent, the multivalent metal ions released into the solution react directly with component b), the at least one water-soluble gelling agent. When the second composition comprises component a), the multivalent metal ions released into the solution will be largely captured by the water soluble chelating agent. A few free multivalent metal ions react in solution with the water soluble gelling agent and begin to form a gel on the towel surface. As the concentration of free multivalent metal ions decreases over time, the sequestered multivalent metal ions will gradually release, and then form a gel on the towel surface. After a short time, a transition of the tissue texture and a uniform gel on the tissue surface was observed.

Multivalent metal ion chelating agents

The second composition according to the invention comprises an optional component a), i.e. at least one water-soluble multivalent metal ion chelating agent, to promote texture transformation, in particular at least to enhance moisture or active delivery capacity. The water-soluble multivalent metal ion chelating agent is water-soluble.

According to the invention, the water-insoluble multivalent metal ion donor releases more or less multivalent metal ions into solution when the first composition is mixed with the second composition comprising component a). Both the chelating agent for the multivalent metal ion and the water-soluble gelling agent are capable of binding the multivalent metal ion.

Surprisingly, the specific chelating agents according to the invention overcome the gelling agent in competition for binding to the multivalent metal ions, such that the released multivalent metal ions are mostly captured by the water-soluble chelating agent. There are still a few free multivalent metal ions in solution that react with the water soluble gelling agent and begin to form a gel on the towel surface. As the concentration of free multivalent metal ions decreases over time, the sequestered multivalent metal ions will gradually release, and then form a gel on the towel surface. That is, the specific chelator according to the invention acts as a reservoir (reservoir) of multivalent metal ions for gel formation on the tissue surface.

Useful multivalent metal ion chelators according to the invention include aminocarboxylic acids such as ethylenediamine tetraacetic acid (EDTA), aminotriacetic acid, diethylenetriamine pentaacetic acid, in particular their alkali metal salts such as N, N-bis (carboxymethyl) glutamic acid, tetrasodium EDTA, the tetrasodium salt of N, N-bis (carboxymethyl) glutamic acid (glutamic diacetic acid, GLDA); hydroxycarboxylic acids, such as citric acid, tartaric acid, glucuronic acid, succinic acid, ethylenediamine disuccinic acid (EDDS), in particular their alkali metal salts; hydroxy amino carboxylic acids, such as hydroxyethyl ethylenediamine triacetic acid (HEDTA), dihydroxyethyl glycine (DEG), in particular their alkali metal salts; polyphosphonic acids, in particular alkali metal salts thereof; other organic acids containing phosphorus (phosphorus), such as phytic acid, in particular alkali metal salts thereof, such as sodium phytate, potassium phytate; polycarboxylic acids, such as polyacrylic acid, polymethacrylic acid, in particular their alkali metal salts.

In one embodiment, the at least one water-soluble multivalent metal ion chelating agent is an alkali metal hydroxy polycarboxylate represented by an alkane containing 1 to 4 carbon atoms, preferably containing 2 or 3 carbon atoms, substituted with 1, 2 or 3 hydroxy groups (-OH), preferably with one (1) hydroxy group, and further with 2, 3, 4 or 5 carboxylic acid/carboxylate groups (-COOM), preferably with 2 or 3 carboxylic acid/carboxylate groups (-COOM), wherein a plurality of groups M independently represent H or an alkali metal, provided that at least one group M represents an alkali metal, such as Na, K or Li, preferably all groups M represent an alkali metal, such as Na, K or Li, preferably Na. More specifically, the at least one alkali metal hydroxypolycarboxylate may be selected from sodium tartrate, sodium citrate, potassium tartrate, potassium citrate and hydrates thereof, preferably sodium citrate, in particular trisodium citrate. Sodium citrate is used herein to refer to monosodium citrate, disodium citrate, and trisodium citrate, and other alkali metal hydroxy polycarboxylates may be understood in a similar manner.

The alkali metals mentioned above are particularly preferably sodium or potassium, in particular sodium. Accordingly, preferred chelating agents may include sodium citrate, tetrasodium EDTA, tetrasodium GLDA, trisodium EDDS, sodium phytate, or mixtures thereof.

In particular, the second composition of the invention may comprise the at least one water-soluble multivalent metal ion chelating agent in an amount of 0.1 to 1 wt. -%, in particular 0.2 to 0.4 wt. -%, relative to the total weight of the second composition.

Water-soluble gelling agent

The second composition according to the invention comprises at least one water-soluble gelling agent which can form a gel with multivalent metal ions to induce a texture transition.

In the present application, the term "water-soluble gelling agent" particularly refers to a gelling agent that can form a gel with the multivalent metal ions from the first composition.

According to the invention, the water-insoluble multivalent metal ion donor releases more or less multivalent metal ions into the solution when the first composition is mixed with the second composition.

In accordance with the principles of the present invention, the gelling agent may thus be any gelling agent that can form a gel with multivalent metal ions. Examples of gelling agents may include gelatin proteins, pectins, gellan gum, carrageenan, agar, alginic acid compounds, in particular alkali metal salts of alginic acid, such as sodium alginate, and mixtures thereof. When the second composition comprises component a), i.e. the chelating agent, the gelling agent and the chelating agent are specifically selected, wherein the gelling agent has a lower capacity to bind to multivalent metal ions than the chelating agent does to bind to multivalent metal ions, such that the gelling agent does not bind to free multivalent metal ions released directly from the first composition, but to multivalent metal ions released subsequently from the reservoir (reservoir), i.e. the chelated multivalent metal ions. Accordingly, a gel may be formed on the surface of the first composition.

Pectin is a linear polymer of alpha-D-galacturonic acid (at least 65%) linked in the 1-and 4-positions to a proportion of carboxylic acid groups esterified with methanol groups. About 20% of the sugars constituting the pectin molecule are neutral sugars (L-rhamnose, D-glucose, D-galactose, L-arabinose, D-xylose). L-rhamnose residues are found in all pectins and are incorporated in the backbone in the 1,2 position.

The uronic acid molecule carries a carboxyl function. When they are COO ^- In its form, this functionality imparts ion exchange capacity to pectin. Divalent ions, in particular calcium, have the ability to form an ionic bridge between two carboxyl groups of two different pectin molecules.

In the natural state, a proportion of the carboxyl groups are esterified with methanol groups. The natural degree of esterification of pectin can be between 70% (apple, lemon) and 10% (strawberry), depending on the source used. With pectin having a high degree of esterification, it is possible to hydrolyze-COOCH ₃ Groups to obtain weakly esterified pectin. Depending on the proportion of methylated or unmethylated monomers, the chains are therefore more or less acidic. HM (high methoxy) pectin is thus defined as having a degree of esterification of more than 50% and LM (low methoxy) pectin is defined as having a degree of esterification of less than 50%.

In the case of amidated pectins, -OCH ₃ The radical being-NH ₂ And (3) group substitution.

Pectin is sold by, inter alia, cargill under the name Uninectine ™, CP-Kelco under the name Genu and Danisco under the name Grinsted Pectin.

Carrageenan is an anionic polysaccharide that constitutes the cell wall of various red algae (Rhodophyceae) belonging to the families of the huperziaceae (gigartinaceae), sha Caike (hypneceae), furseliaceae (furselariaceae) and polysaccharidaceae (polysaccharidae). They are typically obtained by hot water extraction from natural strains of the algae. These linear polymers formed from disaccharide units consist of two D-galactopyranose units, which are alternately linked by alpha (1, 3) and beta (1, 4) linkages. They are highly sulfated polysaccharides (20-50%) and the α -D-galactopyranosyl residues may be in 3, 6-anhydro form. Several types of carrageenans are distinguished by the number and position of sulfate groups on the repeating disaccharide of the molecule, namely: kappa carrageenan with one sulfate group, iota carrageenan with two sulfate groups and lambda carrageenan with three sulfate groups.

Carrageenan consists essentially of the potassium, sodium, magnesium, triethanolamine and/or calcium salts of the polysaccharide sulfate.

Carrageenan is especially available from SEPPIC company as Solagum ^® Named, by Gelymar company under Carragel ^® 、Carralact ^® And Carrasol ^® Named by Cargill under the names Satiagel ™ and Satiagel ™, and by CP-Kelco under the name Genulocta ^® 、Genugel ^® And Genuvisco ^® Is sold for the name.

Agar is a galactose polysaccharide contained in the cell walls of some of the red algae (rhodophyceae) of these species. They are formed from polymeric groups whose basic backbone is beta (1, 3) D-galactopyranose and alpha (1, 4) L3-6 anhydrogalactose chains, these units being repeated regularly and alternately. Differences within the agar family are attributed to the presence or absence of solvated methyl or carboxyethyl groups. These hybrid structures are typically present in variable percentages, depending on the species of algae and the harvest season.

Agar is present at 40,000 to 300,000 g.mol ^-1 A mixture of high molecular mass polysaccharides (agarose and sepharose). By preparing an algae extract, typically by autoclaving, and by treating an extract containing approximately 2% agarThese liquids are obtained by extracting agar.

Agar is for example produced by B & V Agar generators groups under the name Gold Agar, by Hispar company under the names Agarite and Grand Agar, and by Setexam company under the names Agar-Agar, QSA (Quick Soluble Agar) and Puragar.

Gellan gum is an anionic linear heteropolyglycoside based on an oligoglycoside (oligoside) unit consisting of 4 sugars. D-glucose, L-rhamnose and D-glucuronic acid in a ratio of 2:1:1 are present in the gellan gum in the form of monomer units (monomer elements).

For example sold by CP Kelco under the name Kelcogel CG LA.

In one embodiment of the invention, the gelling agent is preferably selected from alkali metal alginic acid compounds. Particularly preferred gelling agents are alginates, such as sodium or potassium alginate, especially sodium alginate.

According to one embodiment, the at least one water-soluble gelling agent is present in the second composition in 0.1 to 0.5 wt%, preferably 0.1 to 0.3 wt%, relative to the total weight of the second composition.

According to the invention, the amounts of chelating agent and gelling agent are selected such that the molar ratio of the portion of chelating agent that is sequesterable with multivalent cations to the portion of gelling agent that is releasable with multivalent cations to form a gel is from about 10:1 to about 1:1, preferably from about 5:1 to about 2:1.

Alkali metal alginic acid compound

The term "alkali metal alginate compound" refers in particular to alkali metal alginate (alginate) or alkali metal salts of alginic acid derivatives. The alkali metal alginic compound is water soluble.

Alginic acid-a natural substance obtained from brown algae or from certain bacteria, is composed of two uronic acids linked together via a 1, 4-glycosidic bond: a polyuronic acid comprising beta-D-mannuronic acid (M) and alpha-L-glucuronic acid (G).

Alginic acid can form water-soluble salts (alginates) with alkali metals such as sodium, potassium or lithium. These alginates are water soluble in aqueous media at pH 4, but dissociate into alginic acid at a pH below 4.

Methods for recovering these water-soluble salts, particularly sodium alginate, from natural sources are well known and are described, for example, in Green, U.S. patent No. 2,036,934 and Le Gloahec, U.S. patent No. 2,128,551.

Alginic acid or alginate may be chemically modified, especially with urea or urethane groups, or by hydrolysis, oxidation, esterification, etherification, sulfation (sulfation), phosphorylation (phosphorylation), amination, amidation or alkylation reactions, or by several of these modifications, to form alginic acid derivatives, including salts.

These derivatives may be anionic, cationic, amphoteric or nonionic and are capable of forming water soluble salts with alkali metals, such as sodium, potassium or lithium, to form alkali metal salts of alginic acid derivatives.

More specifically, the alginate may be reacted with an alkylene oxide, such as ethylene oxide or propylene oxide, to form a polyglycol alginate (polyglycol alginates). The polyglycol segment is bonded to the alginate via one or more carboxyl groups. Typically, alginate reacts with propylene oxide to form polypropylene glycol alginate (PPG alginate), and ethylene oxide to form polyethylene glycol alginate (PEG alginate). The preparation of polyglycol alginate is disclosed in Strong, U.S. Pat. No. 3,948,881, pettitt, U.S. Pat. No. 3,772,266 and Steiner, U.S. Pat. No. 2,426,125.

Preferably, the polyglycol alginate has a degree of esterification of from about 40% to about 95%, more preferably from about 70% to 95%.

Suitable alginates have a weight average molecular weight of from about 20,000 daltons to about 500,000 daltons. As in Martinsen et al, "Comparison of Different Methods for Determination of Molecular Weights and Molecular Weight Distribution of Alginates" (carbohydrate. Polym., 15, 171-193, 1991), the intrinsic viscosity is first determined and then the weight average molecular weight is calculated using the Mark-Houwink Sakurada equation.

The weight average molecular weights indicated above also apply to the alkali metal salts of alginic acid derivatives.

A list of various commercially available alginates, their nature and their sources can be found in Shapiro, U.S. Pat. No. 6,334,968, table 1, column 16, line 49 through column 17, line 18, incorporated herein by reference.

According to one embodiment of the present invention, the alkali metal alginic compound may be selected from sodium alginate and potassium alginate, preferably sodium alginate.

Representative of alkali metal alginic acid compounds suitable for use in the present invention may be, for example, cargill Products company under the name Kelcosol, satialgine ™, cecalgum ™ or Alogel ™, FMC biopolymers company under the name Protanal ™, danisco company under the name Grindsed ^® Alginate is named, kimica Algin is named and ISP is Manucol ^® And Manugel ^® Products sold for the name.

Aqueous phase

The second composition according to the invention comprises at least one aqueous phase.

The at least one aqueous phase comprises water.

The aqueous phase may also comprise water-miscible organic solvents (at room temperature: 25 ℃) such as monoalcohols containing from 2 to 6 carbon atoms, for example ethanol or isopropanol; in particular polyols having 2 to 20 carbon atoms, preferably having 2 to 10 carbon atoms, preferably having 2 to 6 carbon atoms, such as glycerol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol or diethylene glycol; glycol ethers (especially containing 3 to 16 carbon atoms), such as mono-, di-or tri-propylene glycol (C) ₁ -C ₄ ) Alkyl ethers, mono-, di-or tri-ethylene glycol (C) ₁ -C ₄ ) Alkyl ethers, and mixtures thereof.

The aqueous phase may also comprise any water-soluble or water-dispersible compound compatible with the aqueous phase, such as hydrophilic gelling agents, preservatives or surfactants, and mixtures thereof.

In particular, the second composition of the invention may comprise said at least one aqueous phase in a content of from 10% to 99% by weight, in particular from 50% to 99% by weight, more in particular from 70% to 99% by weight, relative to the total weight of the second composition.

Hydrophilic gelling agents

The second composition according to the invention may optionally comprise at least one additional hydrophilic gelling agent.

For the purposes of the present invention, the term "hydrophilic gelling agent" refers to a compound that is capable of gelling the aqueous phase without binding to the multivalent metal ions from the first composition.

The gelling agent may be water-soluble or water-dispersible.

More specifically, the hydrophilic gelling agent may be selected from synthetic polymeric gelling agents, polymeric gelling agents of natural or natural origin, or mixtures thereof.

Synthetic polymeric gellants

For the purposes of the present invention, the term "synthetic" means that the polymer is not a derivative of a naturally occurring or not naturally derived polymer.

The synthetic polymeric gellants contemplated according to the present invention may or may not be microparticles.

For the purposes of the present invention, the term "microparticle" when used in the synthesis of a polymeric gellant means that the polymer is in the form of particles, preferably spherical particles.

More specifically, these polymers may be chosen, inter alia, from:

modified or unmodified carboxyvinyl polymers, e.g. Carbopol from Goodrich ^® (CTFA name: carbomer) products sold under the name; polyacrylates, polymethacrylates, e.g. from Guardian under the name Lubrajel ™ and Norgel or from Hispo Chimica under the name Hispagel ^® Products sold for name; polyacrylamide; optionally crosslinked and/or neutralized 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers, e.g. from Clariant company as Hostacein AMPS ^® Poly (2-acrylamido-2-methylpropanesulfonic acid) (CTFA name: ammonium polyacryl dimethyl taurate (ammonium polyacryldimethyltauramide)) sold by name; acrylamide and AMPS ^® In the form of a W/O emulsion, such as that sold by the company SEPPIC under the name Sepigel ™ 305 (CTFA name: poly)acrylamide/C _13-14 Isoparaffin/laureth-7) and under the name Simulgel ™ 600 (CTFA name: acrylamide/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate 80); and mixtures thereof.

Preferably, these polymers may be selected from acrylates/acrylic acid C _10-30 Alkyl ester crosslinked polymers, e.g. Carbopol ^® ultrez 20、Carbopol ^® ultrez 21、Permulen™ TR-1、Permulen™ TR-2、Carbopol ^® 1382、Carbopol ^® ETD 2020, carbomers, e.g. Synthalen ^® K、Carbopol ^® 980. Ammonium acryloyldimethyl taurate/steareth-8 methacrylate copolymers, e.g. Aristoflex ^® SNC, acrylate copolymers, e.g. Carbopol ^® Aqua SF-1, ammonium acryloyldimethyl taurate/steareth-25 methacrylate cross-linked polymers, e.g. Aristoflex ^® HMS, ammonium acryloyldimethyl taurates, e.g. Aristoflex ^® AVC。

Preferably, these polymers may be selected from carboxyvinyl polymers, such as Carbopol ^® Products (carbomers), e.g. Carbopol sold by Lubrizol ^® Ultrez 20 Polymer, and Pemulen product (acrylate/acrylic acid C _10-30 Alkyl ester copolymers); polyacrylamide, e.g. SEPPIC under the trademark Sepigel ™ 305 (CTFA name: polyacrylamide/C) _13-14 Isoparaffin/laureth-7) or Simulgel ™ 600 (CTFA name: acrylamide/sodium acryloyldimethyl taurate copolymer/isohexadecane/polysorbate 80); optionally crosslinked and/or neutralized 2-acrylamido-2-methylpropanesulfonic acid polymers and copolymers, e.g. Hoechst under the trademark Hostacein AMPS ^® (CTFA name: ammonium polyacryl dimethyltaurate) sold as poly (2-acrylamido-2-methylpropanesulfonic acid) or Simulgel ™ sold as SEPPIC (CTFA name: sodium polyacryl dimethyltaurate/polysorbate 80/sorbitan oleate); copolymers of 2-acrylamido-2-methylpropanesulfonic acid and hydroxyethyl acrylate, such as Simulgel ™ NS and Sepinov EMT 10 sold by SEPPIC; and mixtures thereof.

Preferably, these polymers may be selected from the group of glyceride/acrylic acid copolymers available from ISP Technologies, inc (United guard inc.) under the trade name Lubrajel ™, in particular in the form of what is known as Lubrajel ™ oil, which contains from about 1.0% to 1.3% of the glyceride/acrylic acid copolymer in an aqueous solution of glycerol (about 40% glycerol). Lubrajel ™ oil also included about 0.6% PVM/MA copolymer (also known as methoxyethylene/maleic anhydride copolymer).

Polymeric gellants of natural or natural origin

For the purposes of the present invention, the term "naturally derived" is intended to mean a polymeric gellant obtained by modification of a natural polymeric gellant.

These gelling agents may be particulate or non-particulate.

More specifically, these gelling agents belong to the class of polysaccharides.

In general, the polysaccharides suitable for use in the present invention may be homopolysaccharides, if polysaccharides, glucans, galactans and mannans, or heteropolysaccharides, such as hemicellulose.

Similarly, they may be linear polysaccharides, such as pullulan, or branched polysaccharides, such as gum arabic and pullulan, or mixed polysaccharides, such as starch.

In general, the polysaccharide may be selected from polysaccharides produced by microorganisms; polysaccharides isolated from algae, and higher plant polysaccharides, such as homogeneous polysaccharides, in particular cellulose and its derivatives or levans, heterogeneous polysaccharides, such as gum arabinles, galactomannans, glucomannans and its derivatives; and mixtures thereof.

In particular, the polysaccharide may be selected from the group consisting of fructans, gellans, glucans, amylose, amylopectin, glycogen, pullulan, dextran, cellulose and derivatives thereof, in particular methylcellulose, hydroxyalkyl cellulose, ethylhydroxyethyl cellulose and carboxymethyl cellulose, mannans, xylans, lignin, arabinans, galactans, polygalacturonic acid (galacturonans), chitin, chitosan, glucuronoxylans (glucoronans), arabinoxylans, xyloglucans, glucomannans, arabinogalactans, glycosaminoglycans (glycosaminoglucans), gum arable, tragacanth, ghatti gum, locust bean gum, galactomannans, such as guar gum and nonionic derivatives thereof, in particular hydroxypropyl guar gum and ionic derivatives thereof, biopolysaccharide gums of microbial origin (biopoly saccharide gums), in particular scleroglucan or xanthan gum, mucopolysaccharides, in particular chondroitin sulfate, and mixtures thereof. These polysaccharides may be chemically modified, in particular with urea or urethane groups, or by hydrolysis, oxidation, esterification, etherification, sulfation (sulfation), phosphorylation (phosphonation), amination, amidation or alkylation reactions, or by several of these modifications.

The resulting derivatives may be anionic, cationic, amphoteric or nonionic.

Advantageously, the polysaccharide may be selected from xanthan gum, scleroglucan gum, guar gum, inulin and pullulan, and mixtures thereof.

In general, such compounds useful in the present invention are selected from those described in particular in the following documents: kirk-Othmer's Encyclopedia of Chemical Technology, third edition, 1982, volume 3, pages 896-900 and volume 15, pages 439-458; polymers in Nature by E.A. MacGregor and C.T. Greenwood, published by John Wiley & Sons, chapter 6, pages 240-328, 1980; books entitled Handbook of Water-Soluble Gums and Resins by Robert L.Davidson, published by McGraw Hill Book Company (1980) and by Industrial gumms-Polysaccharides and their Derivatives, roy L.Whistler, second edition, academic Press Inc.

Rather, these polysaccharides suitable for use in the present invention can be distinguished according to whether they are derived from microorganisms, from algae or from higher plants, and are described in detail below.

Polysaccharides produced by microorganisms

Xanthan gum

Xanthan gum isOn an industrial scale by the bacterium Xanthomonas campestris Xanthomonas campestris) Is produced by aerobic fermentation. Like cellulose, its structure consists of a backbone of beta (1, 4) -linked beta-D-glucose. One of the two glucose molecules carries a trisaccharide side chain consisting of α -D-mannose, β -D-glucuronic acid and terminal β -D-mannose. The internal mannose residues are typically acetylated at carbon 6. About 30% of the terminal mannose residues bear pyruvate groups attached in chelate form between carbon 4 and carbon 6. Charged pyruvic acid and glucuronic acid are ionizable and therefore responsible for the anionic nature of xanthan (negative charge down to a pH equal to 1). The content of pyruvate and acetate residues varies depending on the strain, fermentation process, conditions after fermentation and purification steps. These groups are useful in commercial products as Na ⁺ 、K ⁺ Or Ca ²⁺ Ion neutralization (Satia, inc., 1986). The neutralized form can be converted to the acid form by ion exchange or by dialysis from an acidic solution.

Xanthan gum has a molecular weight between 1 000 000 and 50 000 000 and a viscosity between 0.6 and 1.65 pa.s for an aqueous composition containing 1% xanthan gum (measured at 25 ℃ on a LVT-type brookfield viscometer at 60 rpm).

Representative of xanthan gum are, for example, rhodia Chimie under the name Rhodicare, cargill Texturizing Solutions under the name Satiaxane ™ (for the food, cosmetic and pharmaceutical industries), ADM under the name Novaxan ™ and CP-Kelco under the name Kelzan ^® And Keltrol ^® Products sold for the name.

Pullulan polysaccharide

Pullulan is a polysaccharide composed of maltotriose units, known by the name α (1, 4) - α (1, 6) -glucan. Three glucose units in maltotriose are linked via an alpha (1, 4) glycosidic bond, while successive maltotriose units are linked to each other via an alpha (1, 6) glycosidic bond.

Pullulan is produced, for example, by the Hayashibara group of japan under the designation Pullulan PF 20.

Dextran and dextrorotationDextran sulfate

Dextran is a neutral polysaccharide without any charged groups, which is biologically inert, prepared by fermentation of sugar beet sugar containing only hydroxyl groups. Dextran fractions of different molecular weights can be obtained from natural dextran by hydrolysis and purification. Dextran may be in particular in the form of dextran sulfate.

Dextran is represented by, for example, the products sold by the company Phacosmos under the names Dextran or Dextran T, or by the company Meito Sangyo Co., under the names Dextran 40 Powder or Dextran 70 Powder. Dextran sulfate is sold by PK Chemical A/S under the name Dextran sulfate.

Succinoglycan

Succinoglycan is a high molecular weight extracellular polymer produced by bacterial fermentation, consisting of eight sugar repeating units (8 sugar repeats). Succinoglycans are sold, for example, by Rhodia under the name Rheozan.

Scleroglucan

Scleroglucan is a nonionic branched homopolysaccharide consisting of β -D-glucan units. The molecule consists of a linear backbone formed of D-glucose units linked via β (1, 3) linkages, and wherein one third is linked to a pendant D-glucose unit via β (1, 6) linkages.

A more complete description of scleroglucan and its preparation can be found in patent US 3 301 848.

Scleroglucan is sold, for example, by Alban Miiller under the name Amigel or by Cargill under the name Actigum ™ CS.

Polysaccharide isolated from algae

Alternaria alternata (L.) Gaertn

Furcellaran is commercially available from red algae furcellaran (Furcellaria fasztigiata). Furcellaran is produced, for example, by Est-Agar corporation.

Polysaccharides of higher plants

Polysaccharides of this class can be divided into homogeneous polysaccharides (only one saccharide) and heterogeneous polysaccharides consisting of several types of saccharides.

a) Homogeneous polysaccharide and derivatives thereof

The polysaccharide according to the invention may be selected from cellulose and derivatives or levan.

Cellulose and derivatives

The polysaccharide according to the invention may also be cellulose or a derivative thereof, in particular a cellulose ether or ester (e.g. methylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxymethylpropylcellulose, cellulose acetate, nitrocellulose).

The present invention may also contain a cellulose-based associative polymer.

According to the present invention, the term "cellulose-based compound" refers to any polysaccharide compound having in its structure a linear sequence of anhydroglucopyranose residues (AGU) linked together via β (1, 4) bonds. The repeating units are cellobiose dimers. AGU is in a chair conformation and bears 3 hydroxyl functions: 2 secondary alcohols (at positions 2 and 3) and one primary alcohol (at position 6). The polymers thus formed are bound together via intermolecular bonds of the hydrogen bonding type, thus providing the cellulose with a fibrous structure (about 1500 molecules per fiber).

Depending on the source of the cellulose, the degree of polymerization varies greatly; the value thereof may be several hundred to several tens of thousands.

The hydroxyl groups of cellulose may be partially or fully reacted with various chemical reagents to produce cellulose derivatives having inherent properties. The cellulose derivative may be anionic, cationic, amphoteric or nonionic. Among these derivatives, cellulose ethers, cellulose esters and cellulose ester ethers are distinguished.

Among the nonionic cellulose ethers, alkyl celluloses, such as methyl cellulose and ethyl cellulose, can be mentioned; hydroxyalkyl celluloses such as hydroxymethyl cellulose, hydroxyethyl cellulose and hydroxypropyl cellulose; and mixed hydroxyalkyl alkyl celluloses such as hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose, and hydroxybutyl methylcellulose.

According to the invention, hydroxyalkyl cellulose belongs to the class of nonionic polysaccharides as nonionic cellulose ethers, so that it can be used as a water-soluble polyhydroxy polymer to soften hydroxyl-rich fibers. Thus, according to one embodiment of the invention, the first composition comprises hydroxyl-rich fibers and the second composition comprises hydroxyalkyl cellulose.

Among the anionic cellulose ethers, mention may be made of carboxyalkyl celluloses and salts thereof. For example, carboxymethyl cellulose, carboxymethyl methylcellulose and carboxymethyl hydroxyethyl cellulose and sodium salts thereof may be mentioned.

Among the cationic cellulose ethers, mention may be made of crosslinked or uncrosslinked quaternized hydroxyethyl cellulose.

The quaternizing agent can be, in particular, glycidyl trimethylammonium chloride or fatty amines, such as laurylamine or stearylamine. Another cationic cellulose ether that may be mentioned is hydroxyethyl cellulose hydroxypropyl trimethylammonium.

Quaternized cellulose derivatives are in particular:

quaternized cellulose modified with groups containing at least one fatty chain, such as alkyl, arylalkyl or alkylaryl groups containing at least 8 carbon atoms, or mixtures thereof,

quaternized hydroxyethylcellulose modified with groups comprising at least one fatty chain, such as alkyl, arylalkyl or alkylaryl groups comprising at least 8 carbon atoms, or mixtures thereof.

The alkyl groups carried by the quaternized cellulose or hydroxyethyl cellulose described above preferably contain 8 to 30 carbon atoms. Aryl preferably means phenyl, benzyl, naphthyl or anthracyl.

Pointed out to contain C _8-30 Examples of quaternized alkyl hydroxyethyl cellulose of the fatty chain include the products Quattrisoft LM 200, quattrisoft LM-X529-18-A, quattrisoft LM-X529-18B (C) ₁₂ Alkyl) and Quattrisoft LM-X529-8 (C) ₁₈ Alkyl), and products sold by Croda company Crodacel QM, crodacel QL (C) ₁₂ Alkyl) and Crodacel QS (C ₁₈ Alkyl).

Among the cellulose derivatives, mention may also be made of:

cellulose modified with groups comprising at least one fatty chain, for example with groups comprising at least one fatty chain, such as alkyl groups, in particular C _8-22 Alkyl, arylalkyl and alkylaryl modified hydroxyethylcellulose, e.g. Natrosol Plus Grade 330 CS (C ₁₆ Alkyl), and

cellulose modified with polyalkylene glycol alkylphenyl ether groups, such as product Amercell Polymer HM-1500 (nonylphenyl polyethylene glycol (15) ether) sold by Amerchol.

Cellulose esters include inorganic cellulose esters (cellulose nitrate, sulfate, phosphate, etc.), organic cellulose esters (cellulose monoacetate, triacetate, amidopropionate, acetate butyrate, acetate propionate, acetate trimellitate, etc.), and mixed organic/inorganic cellulose esters such as cellulose acetate butyrate and cellulose acetate propionate. Among the cellulose ester ethers, hydroxypropyl methylcellulose phthalate and ethylcellulose sulfate may be mentioned.

The cellulose-based compounds of the present invention may be selected from unsubstituted cellulose and substituted cellulose. Representative of cellulose and derivatives are, for example, FMC Biopolymers Inc. Avicel ^® (microcrystalline cellulose, MCC) under the name Noviant (CP-Kelco) under the name Cekol (carboxymethyl cellulose), akzo Nobel under the name Akucell AF (sodium carboxymethyl cellulose), dow under the name Methocel ™ (cellulose ether) and Ethocel ™ (ethyl cellulose), and Hercules Aqualon under the name Aqualon ^® (carboxymethyl cellulose and sodium carboxymethyl cellulose), benicel ^® (methyl cellulose), blance ™ (carboxymethyl cellulose), culminal ^® (methylcellulose, hydroxypropyl methylcellulose), klucel ^® (hydroxypropyl cellulose), polysurf ^® (cetyl hydroxyethylcellulose) and Natrosol ^® CS (hydroxyethyl cellulose) is a product sold under the name.

Levan

The polysaccharides according to the invention may in particular be fructans selected from inulin and derivatives thereof (in particular dicarboxylic inulin and carboxymethyl inulin).

Fructans or fructans are oligosaccharides or polysaccharides comprising a sequence of anhydrofructose units optionally in combination with several sugar residues other than fructose. Levan may be linear or branched. Levan may be a product obtained directly from plant or microbial sources, or a product whose chain length has been modified (increased or decreased) by fractionation, synthesis or hydrolysis, in particular by enzymatic means. Levan generally has a degree of polymerization of 2 to about 1000, preferably 2 to about 60.

Three classes of levan are distinguished. The first corresponds to products whose fructose units are mostly linked via a β (2, 1) linkage. These are essentially linear fructans, such as inulin.

The second class also corresponds to linear fructose, but the fructose units are essentially linked via β (2, 6) linkages. These products are levans (levans).

The third class corresponds to mixed levans, i.e., containing β (2, 6) and β (2, 1) sequences. These are essentially branched fructans, such as rye polyfructose (graminans).

The preferred levan in the composition according to the invention is inulin. Inulin may be obtained, for example, from chicory, dahlia or Jerusalem artichoke (Jerusalem artichoke), preferably from chicory.

In particular, polysaccharides, in particular inulin, have a degree of polymerization of 2 to about 1000, preferably 2 to about 60, and a degree of substitution of less than 2 on the basis of one fructose unit.

Representative of inulin for use in the present invention are, for example, orafti under the name Beneo ™ inulin, and Sensus under the name Frutafit ^® Products sold for the name.

b) Heterogeneous polysaccharide and derivatives thereof

The polysaccharide which may be used according to the invention may be a gum such as cassia, karaya, konjac, tragacanth, tara, acacia or acacia.

Gum arabic

Gum arabic is a highly branched acidic polysaccharide in the form of a mixture of potassium, magnesium and calcium salts. The monomeric units of the free acid (Arabic acid) are D-galactose, L-arabinose, L-rhamnose and D-glucuronic acid.

Galactomannans (guar gum, locust bean gum, fenugreek gum, tara gum) and derivatives (guar phosphate esters, hydroxypropyl guar, etc.)

Galactomannans are nonionic polyglycosides extracted from the endosperm of leguminous seeds, which constitute the storage carbohydrate of leguminous seeds.

Galactomannans are macromolecules composed of a backbone of β (1, 4) -linked D-mannopyranose units with side branches composed of a single D-galactopyranose unit, which is α (1, 6) linked to the backbone. The various galactomannans differ firstly in the proportion of alpha-D-galactopyranose units present in the polymer and secondly in the significant differences in the distribution of galactose units along the mannose chains.

Guar gum has a mannose/galactose (M/G) ratio of about 2, tara gum has a mannose/galactose (M/G) ratio of 3, and locust bean gum has a mannose/galactose (M/G) ratio of 4.

Guar gum

Guar gum is characterized by a mannose/galactose ratio of about 2/1. Galactose groups are regularly distributed along the mannose chains.

Guar gum which can be used according to the invention can be nonionic, cationic or anionic. According to the present invention, chemically modified or unmodified nonionic guar can be used.

Unmodified nonionic guar gum is, for example, unipecine under the name Vidogum GH, vidogum G and Vidocrem and Rhodia under the name Jaguar, danisco under the name Meypro ^® Guar is named, cargill is named Viscogma ™ and Aqualon is named Supercol ^® Guar gum is a product sold under the name guar gum.

Representative of hydrolyzed nonionic guar gum which can be used according to the present invention are, for example, the company Danisco with Meypror ^® Products sold for the name.

Modified nonionic guar usable according to the invention is preferably C ₁ -C ₆ Hydroxyalkyl modifications, among which mention may be made of, for example, hydroxymethyl, hydroxyethyl, hydroxypropyl and hydroxybutyl.

Such nonionic guar optionally modified with hydroxyalkyl groups are known, for example, from Rhodia under the trade names Jaguar HP 60, jaguar HP 105 and Jaguar HP 120 (hydroxypropyl guar) or Aqualon under the N-Hance ^® HP (hydroxypropyl guar) is sold under the name.

The cationic galactomannan gum preferably has a cationic charge density of less than or equal to 1.5 meq/g, more particularly between 0.1 and 1 meq/g. The charge density can be determined by the Kjeldahl method. Which generally corresponds to a pH of about 3 to 9.

Generally, for the purposes of the present invention, the term "cationic galactomannan gum" refers to any galactomannan gum containing cationic groups and/or groups ionizable into cationic groups.

Preferred cationic groups are selected from those comprising primary, secondary, tertiary and/or quaternary amine groups.

The cationic galactomannan gum used typically has a molecular weight of between about 500 and 5 x 10 ⁶ Between, preferably about 10 ³ Up to 3X 10 ⁶ Weight average molecular mass in between.

Cationic galactomannan gums which can be used according to the present invention are, for example, those comprising tri (C) _1-4 ) Gums of alkylammonium cationic groups. Preferably, 2% to 30% of the hydroxyl functional number of these gums bears trialkylammonium cationic groups.

Among these trialkylammonium groups, mention may most particularly be made of trimethylammonium and triethylammonium groups.

More preferably, these groups represent 5 to 20% by weight relative to the total weight of the modified galactomannan gum.

According to the invention, the cationic galactomannan gum is preferably guar gum comprising hydroxypropyl trimethylammonium groups, i.e. guar gum modified with 2, 3-epoxypropyl trimethylammonium chloride, for example.

These galactomannan gums, in particular guar gums modified with cationic groups, are products known per se and are described, for example, in the patents US 3 589 578 and US 4 031 307. Furthermore, these products are known in particular from Rhodia under the trade names Jaguar EXCEL, jaguar C13S, jaguar C15, jaguar C17 and Jaguar CI 62 (guar hydroxypropyl trimethylammonium chloride), from Degussa under the Amilan name ^® Guar (Guar hydroxypropyl trimethyl ammonium chloride) is named and is available from Aqualon corporation as N-Hance ^® 3000 (guar hydroxypropyl trimethylammonium chloride) is sold under the name.

Anionic guar useful according to the present invention is a polymer comprising groups derived from carboxylic, sulfonic, sulfenamic, phosphoric, phosphonic or pyruvic acids. The anionic groups are preferably carboxylic acid groups. The anionic groups may also be in the form of acid salts, in particular sodium, calcium, lithium or potassium salts.

The anionic guar which can be used according to the invention is preferably a carboxymethyl guar derivative (carboxymethyl guar or carboxymethyl hydroxypropyl guar).

Locust bean gum

Locust bean gum is extracted from the seeds of locust bean tree carob (Ceratonia siliqua).

Unmodified locust bean gum which can be used in the present invention is for example named Viscogn ™ by Cargill company, vidogum L by Unipektin company and Grisco by Grinsted by Danisco company ^® LBG is sold under the name.

Representative of chemically modified locust bean gum useful in the present invention may be, for example, cationic locust bean gum sold by the company Toho under the name of Catinal CLB (locust bean gum hydroxypropyl trimethylammonium chloride).

Tara adhesive

Tara gums useful in the context of the present invention are sold, for example, by Unipektin under the name Vidougum SP.

Glucomannan (konjak gum)

Glucomannans are polysaccharides of high molecular weight (500 000 < M glucomannans < 2 000 000) consisting of D-mannose and D-glucose units, with about one branch per 50 or 60 units. It is present in wood but is also the main component of konjac glucomannan. Konjak (Amorphophallus konjac) is a plant of the Araceae family.

The products which can be used according to the invention are, for example, those available from Shimizu corporation under the Propol name ^® And Rheolex ^® Is sold for the name.

Other polysaccharides

Among the other polysaccharides which can be used according to the invention, mention may also be made of chitin (poly-N-acetyl-D-glucosamine, beta (1, 4) -2-acetamido-2-deoxy-D-glucose), chitosan and derivatives (chitosan-beta-glycerophosphate, carboxymethyl chitin, etc.), such as those sold by franke-chitosan company; glycosaminoglycans (GAGs) such as hyaluronic acid, chondroitin sulfate, dermatan sulfate, keratan sulfate, preferably hyaluronic acid; xylan (or arabinoxylan) and derivatives.

Arabinoxylans are polymers of xylose and arabinose, both classified under the pentosan name. Xylan consists of a backbone of β (1, 4) -linked D-xylose units, and three substituents are present thereon (Rouau & Thibault, 1987): the acid unit, α -L-arabinofuranose unit, may contain side chains of arabinose, xylose, galactose and glucuronic acid.

According to this variant, the polysaccharide is preferably hyaluronic acid or a salt thereof.

The at least one hydrophilic gelling agent may be present in an amount of, for example, 0.001 wt% to 10 wt%, preferably 0.01 wt% to 5 wt%, more preferably 0.05 wt% to 3 wt%, relative to the total weight of the second composition.

Active agent

According to one embodiment of the invention, the first composition may comprise at least one active agent.

According to one embodiment of the invention, the second composition may comprise at least one active agent.

When the first composition comprises the at least one active agent, it may be incorporated into the first composition, in particular by means of an alternating electric field. The one or more active agents may be incorporated, in particular, in the powder state.

Among all the active agents which can be used in the present invention, mention may be made in particular of: alpha-or beta-hydroxy acids, such as lactic acid, glycolic acid, citric acid, 5-octanoylsalicylic acid, alpha-hydroxydecanoic acid, alpha-hydroxy lauric acid, tartaric acid, glucuronic acid, galacturonic acid, acrylic acid, alpha-hydroxybutyric acid, alpha-hydroxyisobutyric acid, malic acid, mandelic acid, phosphoric acid, pyruvic acid, lactobionic acid and salicylic acid.

Anti-acne agents such as salicylic acid or benzoyl peroxide, octopirox, dextro-and levo-sulfur-containing amino acids, their salts and their N-acetyl derivatives such as N-acetylcysteine, or agents which attempt to prevent skin aging and/or improve its condition, such as the alpha-and beta-hydroxy acids mentioned above, retinoids such as retinoic acid, retinol and its esters, e.g. retinol propionate and retinol acetate, or retinol palmitate, nicotinamide, allantoin, aloe vera extract, azelaic acid, bisabolol, phytic acid, collagen, or agents which stimulate collagen formation, vitamins such as vitamin C or derivatives thereof, such as ascorbyl glucoside, vitamin E or derivatives thereof, vitamin a or derivatives thereof, vitamin F or derivatives thereof, dextro-and levo-sulfur-containing amino acids and derivatives thereof as mentioned above, elastin, N-acetyl D-glucosamine, luteolin or antioxidants, such as green tea or active fractions thereof, glycerol, laponite, caffeine, aromatic essential oils (essential aromatic oils), colorants, radical scavengers, humectants, depigmenting agents (depigmenting agents), agents for improving skin color, such as artificial tanning agents of the dihydroxyacetone or tyrosine ester type, sebum regulators (lipo-regulators), softeners, anti-wrinkle agents, keratolytic agents, refreshing agents (freshenes), deodorants, anesthetics, nutritional agents and mixtures thereof. Bleaching agents (bleaching agents) such as kojic acid, ascorbyl phosphate, ascorbyl glucoside, ascorbic acid and mixtures thereof may also be used.

In the case of facial masks, active agents for improving skin conditions, such as moisturizers or agents that help improve the natural lipid barrier, such as ceramides, cholesterol sulfates and/or fatty acids and mixtures thereof, may also be used. Enzymes active on the skin, such as proteases, lipases, cerebrosidase and/or melanases and mixtures thereof may also be used.

As other examples of active agents that may be suitable for use in the practice of the present invention, there are pharmaceutical agents (agents for drugs), peptides, proteins, detectable labels (detectable labels), contrast agents, analgesics, anesthetics, antibacterial agents, antiyeast agents, antifungal agents, antiviral agents, anti-dermatitis agents, antipruritics, antiemetics, vascular protectants, antihalation agents, anti-irritants, anti-inflammatory agents, immunomodulators, anti-hyperkeratosis agents (anti-hyperkeratolytic agents), dry skin treatments, antiperspirants, antipsoriatic agents, anti-dandruff agents, anti-aging agents, anti-asthma agents and bronchodilators, sunscreens, antihistamines, healing agents, corticosteroids, tanning agents, and mixtures thereof.

The amount of the at least one active agent in the first composition and/or the second composition may be adjusted according to the intended use of the kit.

Alkali metal hyaluronate compound

Hyaluronic acid compounds may also be used as active agents according to the invention. The hyaluronic acid compound is preferably an alkali metal hyaluronic acid compound.

The term "alkali metal hyaluronate compound" refers in particular to an alkali metal salt of hyaluronic acid (hyaluronate) or a derivative thereof. The alkali metal hyaluronate compound is water soluble.

In the context of the present invention, the term "hyaluronic acid or derivative thereof" specifically covers the basic units of hyaluronic acid of the formula:

。

it is the smallest fraction (fraction) of hyaluronic acid comprising disaccharide dimers, D-glucuronic acid and N-acetamido glucose.

The term "hyaluronic acid or derivative thereof" also comprises in the context of the present invention linear polymers comprising the above-mentioned polymeric units linked together in the chain via alternating β (1, 4) and β (1, 3) glycosidic linkages, the molecular weight (Mw) of which may be between 380 and 13 000 000 daltons. Such molecular weight depends to a large extent on the source of the hyaluronic acid obtained and/or the method of preparation.

In the natural state, hyaluronic acid is present in pericellular gels (pericellular gels), in the matrix of connective tissue of vertebrate organs, such as dermis and epithelial tissue, and in particular in the epidermis, in synovial fluid of joints, in vitreous humor, in human umbilical cord and in cockscomb (crista galli apophysis).

Thus, the term "hyaluronic acid or derivative thereof" comprises all fractions or subunits (sub-units) of hyaluronic acid having a molecular weight in particular within the molecular weight ranges highlighted above.

As an illustration of the various hyaluronic acid fractions, reference may be made to the "Hyaluronan fragments: an information-rich system", R.Stern et al European Journal of Cell Biology (2006) 699-715, which reviews the listed biological activities of hyaluronic acid according to molecular weight.

According to a preferred embodiment of the invention, the hyaluronic acid fraction suitable for the uses covered by the invention has a molecular weight of between 50 and 5 000 Da, in particular between 100 000 and 5 000 Da, especially between 400 000 and 5 000 Da. In this case, the term used is high molecular weight hyaluronic acid.

Alternatively, the hyaluronic acid fraction, which is also suitable for the uses covered by the invention, has a molecular weight between 50 000 and 400 000 Da. In this case, the term used is medium molecular weight hyaluronic acid.

Still alternatively, the hyaluronic acid fraction applicable for the uses covered by the invention has a molecular weight of less than 50 000 Da. In this case, the term used is low molecular weight hyaluronic acid.

Finally, the term "hyaluronic acid or derivative thereof" also comprises hyaluronic acid esters, in particular those in which all or part of the carboxylic groups of the acid function are esterified with an oxyethylenated alkyl group or alcohol containing from 1 to 20 carbon atoms, in particular having a degree of substitution at the D-glucuronic acid level of hyaluronic acid of from 0.5 to 50%.

More specifically, hyaluronic acid or hyaluronate may be reacted with an alkylene oxide, such as ethylene oxide or propylene oxide, to form a polyglycol hyaluronate (polyglycol hyaluronates). The polyglycol segment is bonded to the hyaluronic acid via a carboxyl group. Typically, hyaluronic acid or hyaluronate is reacted with propylene oxide to form polypropylene glycol hyaluronate, and ethylene oxide to form polyethylene glycol hyaluronate.

Mention may also be made of the methyl, ethyl, n-propyl, n-pentyl, benzyl and dodecyl esters of hyaluronic acid. These esters are described in particular in D. Campoccia et al, "Semisynthetic resorbable materials from hyaluronan esterification", biomaterials 19 (1998) 2101-2127.

The molecular weights indicated above also apply to the hyaluronate.

Auxiliary agent

In a known manner, the second composition according to the invention may also contain adjuvants usual in cosmetics and/or dermatology, such as preservatives, antioxidants, pH regulators (acidic or basic), fragrances, fillers, bactericides, odor absorbers, colorants (pigments and dyes), emulsifiers and lipid vesicles.

Needless to say, the person skilled in the art will take care to choose this or these optional further compounds and/or their amounts such that the addition considered does not or substantially does not adversely affect the benefit of the second composition according to the invention.

Galenic form (Galenic form)

The second composition according to the invention may be in various forms, in particular in the form of an aqueous solution, dispersion or emulsion, such as in particular a water/oil or oil/water emulsion or multiple emulsion.

The emulsion may have an oily or aqueous continuous phase. Such emulsions may be, for example, reverse phase (W/O) emulsions or direct (O/W) emulsions, or multiple emulsions (W/O/W or O/W/O).

In the case of emulsions, direct (O/W) emulsions are preferred.

In particular, the second composition according to the invention may be in the form of an oil-in-water (O/W) emulsion, a water-in-oil (W/O) emulsion or a multiple emulsion, preferably an oil-in-water (O/W) emulsion.

The second composition of the present invention is preferably an aqueous solution.

According to a preferred embodiment of the invention, the kit is presented as a mask comprising:

1) A nonwoven fabric (or towel) made of hydroxyl-rich fibers comprising 0.01 to 5 wt%, preferably 0.02 to 1 wt%, or preferably 0.04 to 0.5 wt%, and 0.001 to 1 wt%, especially 0.01 to 0.1 wt%, such as 0.01 to 0.06 wt%, HEC or HPC, relative to the total weight of the nonwoven fabric, and

2) A composition comprising, relative to the total weight of the composition, from 10% to 99% by weight, preferably from 50% to 99% by weight, of at least one aqueous phase, from 0.1% to 0.5% by weight, preferably from 0.1% to 0.3% by weight of sodium alginate and from 0.1% to 0.5% by weight, preferably from 0.2% to 0.4% by weight of sodium citrate,

wherein the weight ratio of the nonwoven fabric to the composition is from 1:3 to 1:20, preferably from 1:8 to 1:15.

Different embodiments of the kit

Based on a discussion of a kit according to the present invention comprising a first composition and a second composition, it is to be understood that the following embodiments are also within the spirit of the present invention.

Specifically, according to the present invention, there is provided a mask pack 1 comprising:

1) A first composition comprising at least one water-insoluble multivalent metal salt and at least one water-soluble polyhydroxy polymer, and

2) A fourth composition that is free of water comprising:

a) At least one water-soluble multivalent metal ion chelating agent, and

b) At least one water-soluble gelling agent capable of forming a gel with the polyvalent metal ion,

wherein the first composition and the fourth composition are placed apart from each other.

For such a mask pack 1, the first composition and its components, including the water insoluble salt and the water soluble polyhydroxy polymer, and the fourth composition, including the water soluble chelating agent, the water soluble gelling agent, etc., may be substantially identical to the kit of the present invention, wherein the fourth composition substantially corresponds to the second composition except that no water is present. The mask pack 1 may also be constructed substantially the same as the kit of the present invention. In addition, the amounts of the composition of the mask pack 1, the components of the composition and the ratio therebetween may be referred to the kit of the present invention.

To apply the mask pack 1, the fourth composition may be mixed with water to form an aqueous solution of the fourth composition. Obviously, such an aqueous solution substantially corresponds to the second composition of the kit according to the invention. The aqueous solution is then mixed with the first composition, for example with reference to the way in which the first composition and the second composition of the kit according to the invention are mixed.

In particular, the mask pack 1 according to the present invention comprises:

1) A nonwoven fabric (or towel) comprising 0.01 to 5 wt%, preferably 0.02 to 1 wt%, or preferably 0.04 to 0.5 wt% of calcium sulphate or calcium carbonate and 0.001 to 1 wt%, especially 0.01 to 0.1 wt%, such as 0.01 to 0.06 wt% of HEC or HPC, relative to the total weight of the nonwoven fabric, and

2) A fourth composition which is free of water and comprises, relative to the total weight of the composition, from 0.1% to 0.5% by weight, preferably from 0.1% to 0.3% by weight, of a water-soluble chelating agent and from 0.1% to 0.5% by weight, preferably from 0.2% to 0.4% by weight, of a water-soluble gelling agent,

wherein the weight ratio of nonwoven to the fourth composition is from 1:3 to 1:20, preferably from 1:8 to 1:15.

Method and use

The first composition and the second/fourth composition according to the present invention may be generally prepared according to common general knowledge of a person skilled in the art. However, it is to be understood that the skilled person may choose a preparation method based on his general knowledge, taking into account the nature of the ingredients used, e.g. their solubility in the vehicle and the envisaged use for the composition or kit.

According to one embodiment, the kit according to the invention can be used for caring for keratin materials, in particular the face. Such use may be represented by a method of caring for keratin materials, in particular the face, comprising the step of compounding the first and second compositions of the kit in a predetermined weight ratio, and then applying the mixture thus obtained as a mask to the keratin materials.

According to one embodiment, the kit according to the invention may be used for managing skin wounds, for preventing post-operative adhesion formation or for filling or repairing osteochondral defects, etc. Such use may be manifested as a method of managing skin wounds, preventing post-operative adhesion formation or filling or repairing osteochondral defects, comprising the steps of compounding the first and second compositions of the kit in a predetermined weight ratio, and then applying as a coating (mask) or a pad (stuffer) to the site where the mixture thus obtained is desired.

Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements. The following examples are intended to illustrate the invention and are not thereby limiting its scope.

Examples

The amounts/concentrations of ingredients in the following compositions/formulations are expressed in weight percent relative to the total weight of each composition/formulation.

Example 1

I. Preparation

As a second composition, inventive formulations a and B and comparative formulation a were prepared.

TABLE 1

In table 1, comparative a does not contain trisodium citrate as compared to formulation a of the present invention.

Procedure for preparing the second composition using the formulation in table 1: all ingredients were placed in a beaker, heated to 60 ℃ and homogenized until uniform, cooled to room temperature.

The preparation procedure of the mask comprises the following steps: each of 0.75 g of formulations A to B and comparative A was put together with a nonwoven fabric of weight 1.3 g made of 20% by weight calcium alginate fibers and 80% by weight lyocell fibers, sold by Sanjiang under the name M762R-40CN, respectively.

II. Evaluation of the mask and comparative mask of the invention

The mask of the present invention and the comparative mask were evaluated using the following procedure.

Texture transition evaluation method

Five panelists visually rated the gel area on the towel and rated from poor to excellent, with the average based on the rating being divided into the following four categories: "excellent" (> 50%), "good" (30-50%), "general" (10-30%) or "poor" (< 10%).

Freshness evaluation method

Five panelists evaluated the skin for greasiness by tactile means as the face gently moved the finger abdomen.

The evaluation method is that the mask is applied to the face for 15 minutes, and then the skin is removed and massaged. The greasy feel of the skin is perceived by moving the abdomen of the finger over the face. Each panel then gave a score of 0 to 15. The lower the greasy feel, the higher the score given.

Evaluation index: we classified from poor to excellent classification into the following four classes based on scores: "excellent" (> 12), "good" (8-12), "general" (4-8), "bad" (0-4).

Skin adhesion evaluation method

Five panelists visually evaluated the degree of facial mask adhesion to the face with a mirror under standardized illumination, and the amount of air bubbles around the eyes, nose and mouth.

The evaluation method is to apply a mask to the face and observe the amount of bubbles around the eyes, nose and mouth. Each panel then gave a score of 0 to 15. The fewer bubbles, the higher the score given.

Hydration effect evaluation method

Five panelists evaluated the hydration of the mask based on the fullness (plumpy), fine line improvement, and soft skin provided by the formulation.

The evaluation method is that the mask is applied to the face for 15 minutes, and then the skin is removed and massaged. The extent of wrinkles on the forehead and nasolabial folds was observed, the cheeks were touched with the index and middle fingers and the skin softness was perceived by tactile means, and the extent of fine lines on the cheeks was observed. Each panel gave a score of 0 to 15. The more skin is full, the higher the score is given.

Method for evaluating moisture delivery ability

Five panelists visually evaluated the amount of juice left on the skin after removal of the mask with a mirror under standardized illumination.

The evaluation method is that the mask is applied to the face for 15 minutes and then removed. The amount of juice left on the skin was visually observed. Each panel then gave a score of 0 to 15. The more juice that remains on the skin, the higher the score given.

The results obtained are detailed in the following table:

TABLE 2

	Formulation A	Formulation B	Comparative formulation A
				Texture transition	Good quality	Excellent in	Difference of difference
Skin adhesion	Excellent in	Excellent in	In general
				Fresh feeling	Excellent in	In general	Good quality
Hydration effect	Good quality	Excellent in	In general
				Moisture delivery capability	Excellent in	In general	Difference of difference

Conclusion (III)

The mask of the present invention is superior to the comparative mask in beneficial properties such as texture transition, hydration effect and moisture delivery ability.

Example 2:

as a first composition, inventive formulation C and comparative formulations B-D were prepared.

TABLE 3 Table 3

The preparation procedure of the mask comprises the following steps: 0.75 grams of formulation A was placed with a 1.3 gram nonwoven made from formulation C and comparative formulations B-D, respectively, to provide mask C and comparative masks B-D, respectively.

II. Evaluation of the mask and comparative mask of the invention

Softness evaluation method

(1) Five panelists manually rated the gel area on the towel by touch and rated from poor to excellent, with the average based on the rating being classified into the following 3 categories: "excellent" (uniform softening), "general" (softening but non-uniform) or "poor" (non-softening).

TABLE 4 Table 4

	Mask C	Contrast mask B	Contrast mask C	Contrast mask D
					Evaluation	Excellent in	In general	In general	Difference of difference

(2) The softening effect is evaluated indirectly by measuring the deformation of the mask, as the softened mask will result in deformation.

Deformation (%) = ((value measured after fresh mixing) - (initial value))/(initial value).

TABLE 5

	Mask C	Contrast mask B
			Deformation of	13.80%	8.42%

Conclusion (III)

The mask of the invention is superior to the comparative mask in softness.

The foregoing description illustrates and describes the present disclosure. In addition, the disclosure shows and describes only the preferred embodiments of the disclosure, but as mentioned above, it is to be understood that variations or modifications can be made within the scope of the concepts as expressed herein commensurate with the above teachings and/or the skill or knowledge of the relevant art. The above description is further intended to explain the best modes known for practicing the disclosure and to enable others skilled in the art to utilize the disclosure in such, or other, embodiments and with the various modifications required by the particular applications or uses disclosed herein. Accordingly, this description is not intended to limit the disclosure to the form disclosed herein. It is also intended that the appended claims be construed to include alternative embodiments.

All publications, patents, and patent applications cited in this specification are herein incorporated by reference for any and all purposes as if each individual publication, patent, or patent application were specifically and individually indicated to be incorporated by reference. In the event of inconsistencies, the present disclosure controls.

Claims

1. A kit, comprising:

1) A first composition comprising at least one water insoluble multivalent metal salt and at least one water soluble polyhydroxy polymer, wherein the water insoluble multivalent metal salt is selected from water insoluble salts of calcium, strontium, zinc, copper, manganese, or mixtures thereof, and wherein the water soluble polyhydroxy polymer comprises polyhydroxy cellulose, and

2) A second composition comprising at least one aqueous phase, and

a) At least one water-soluble multivalent metal ion chelator, wherein the at least one water-soluble multivalent metal ion chelator is selected from the group consisting of sodium citrate, disodium EDTA, tetrasodium GLDA, trisodium EDDS, sodium phytate, potassium phytate, and mixtures thereof, and

b) At least one water-soluble gelling agent capable of forming a gel with multivalent metal ions, wherein the water-soluble gelling agent is selected from the group consisting of alkali metal alginic acid compounds;

wherein the weight ratio of the first composition to the second composition is from 1:3 to 1:20,

wherein the first composition and the second composition are placed apart from each other.

2. The kit according to claim 1, wherein the gelling agent is specifically selected to have a lower capacity to bind multivalent metal ions than the chelating agent.

3. Kit according to claim 1 or 2, wherein the at least one water-insoluble multivalent metal salt is a water-insoluble calcium salt selected from calcium alginate, calcium sulfate and calcium carbonate or mixtures thereof.

4. The kit according to claim 1 or 2, wherein the first composition comprises the at least one water-soluble polyhydroxy polymer in a content of from 0.001% to 1% by weight, relative to the total weight of the first composition.

5. The kit according to claim 1 or 2, wherein the first composition further comprises additional hydroxyl-enriched fibers, wherein the at least one water-insoluble multivalent metal salt and the at least one water-soluble polyhydroxy polymer are loaded onto the additional fibers.

6. The kit of claim 5, wherein the water-insoluble multivalent metal salt is in the form of fibers that are formed with additional fibers into a water-insoluble substrate onto which the water-soluble polyhydroxy polymer is loaded.

7. The kit of claim 6, wherein the water-insoluble substrate comprises water-insoluble multivalent metal salt fibers in an amount of 10 to 80 wt% relative to the total weight of the water-insoluble substrate, and comprises the additional fibers in an amount of 10 to 80 wt%.

8. The kit of claim 5, wherein the additional fibers are formed into a water insoluble substrate onto which both the water insoluble multivalent metal salt and the water soluble polyhydroxy polymer are loaded.

9. The kit of claim 8, wherein the water-insoluble substrate comprises water-insoluble multivalent metal salt fibers in an amount of 0.01 wt% to 5 wt% relative to the total weight of the water-insoluble substrate.

10. The kit according to claim 1 or 2, wherein the multivalent metal ion chelating agent comprises an aminocarboxylic acid, a hydroxycarboxylic acid, a hydroxyaminocarboxylic acid, a polyphosphonic acid, other phosphorus-containing organic acids or mixtures thereof.

11. The kit according to claim 1 or 2, wherein the at least one water-soluble multivalent metal ion chelating agent is present in the second composition at 0.1 to 1 wt% relative to the total weight of the second composition.

12. The kit according to claim 1, wherein the alkali metal alginic compound is selected from alkali metal alginates, alkali metal salts of alginic acid derivatives or mixtures thereof.

13. The kit according to claim 12, wherein the alkali metal alginic compound is selected from sodium alginate and potassium alginate.

14. Kit according to claim 1 or 2, wherein the at least one water-soluble gelling agent is present in the second composition in a range of 0.1 to 0.5% by weight relative to the total weight of the second composition.

15. Kit according to claim 1 or 2, wherein the at least one aqueous phase is present in the second composition in a range of from 10% to 99% by weight relative to the total weight of the second composition.

16. Kit according to claim 1 or 2, wherein the second composition comprises at least one hydrophilic gelling agent and/or at least one active agent.

17. The kit according to claim 1 or 2, wherein the second composition comprises the water-soluble polyhydroxy polymer.

18. Kit according to claim 1 or 2, in the form of a mask comprising:

1) A nonwoven fabric made from hydroxyl-rich fibers comprising 0.01 to 5 wt% of calcium sulfate or calcium carbonate, and 0.001 to 1 wt% of HEC or HPC, relative to the total weight of the nonwoven fabric, and

2) A composition comprising, relative to the total weight of the composition, from 10% to 99% by weight of at least one aqueous phase, from 0.1% to 0.5% by weight of a water-soluble chelating agent and from 0.1% to 0.5% by weight of a water-soluble gelling agent,

Wherein the weight ratio of the nonwoven fabric to the composition is from 1:3 to 1:20.

19. Kit according to claim 1 or 2, wherein the amounts of the chelating agent and the gelling agent are selected such that the molar ratio of the part to be released from the chelating agent that is chelated with multivalent cations to the part to be released from the gelling agent that is gellable with multivalent cations is from 10:1 to 1:1.

20. The kit of claim 1, wherein the water-soluble polyhydroxy polymer comprises hydroxyethyl cellulose, hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose, or hydroxybutyl methylcellulose.

21. The kit of claim 5, wherein the first composition further comprises regenerated cellulose or cotton fibers.

22. The kit of claim 12, wherein the alkali metal alginic compound is selected from the group consisting of sodium alginate, potassium alginate, lithium alginate, sodium alginate polyglycolate, potassium alginate polyglycolate, lithium alginate polyglycolate, or mixtures thereof.

23. The kit of claim 1, wherein the weight ratio of the first composition to the second composition is from 1:8 to 1:15.

24. The kit of claim 19, wherein the amounts of the chelating agent and the gelling agent are selected such that the molar ratio of the portion to be released from the chelating agent that is chelated with multivalent cations to the portion to be released from the gelling agent that is gellable with multivalent cations is from 5:1 to 2:1.

25. Non-therapeutic use of the kit according to any one of the preceding claims for caring for keratin materials.

26. A non-therapeutic method for caring for keratin materials, comprising the step of compounding the first and second compositions of the kit according to any one of the preceding claims 1 to 24 in a weight ratio of the first composition to the second composition ranging from 1:3 to 1:20, and then applying to the location where the mixture thus obtained is desired.

27. Use of a second composition as claimed in any one of the preceding claims 1-24 as a juice or part of a juice of a mask product, wherein the mask product comprises, separate from the second composition, a fabric or towel comprising the at least one water-insoluble multivalent metal salt.

28. A mask pack 1 comprising:

1) A first composition comprising at least one water insoluble multivalent metal salt, at least one hydroxyl-rich fiber, and at least one water soluble polyhydroxy polymer, wherein the at least one water soluble polyhydroxy polymer is homogeneously loaded onto the hydroxyl-rich fiber, wherein the water insoluble multivalent metal salt is selected from water insoluble salts of calcium, strontium, zinc, copper, manganese, or mixtures thereof, and wherein the water soluble polyhydroxy polymer comprises polyhydroxy cellulose, and

2) A fourth composition comprising at least one aqueous phase, and

b) At least one water-soluble gelling agent capable of forming a gel with multivalent metal ions, wherein the at least one water-soluble gelling agent comprises an alkali metal salt of alginic acid,

29. The mask pack 1 of claim 28, wherein the water-insoluble multivalent metal salt is calcium alginate, calcium sulfate, or calcium carbonate.

30. The mask pack 1 of claim 28 or 29, wherein the at least one hydroxyl-rich fiber is selected from the group consisting of viscose, modal, lyocell, cuprammonium, cotton, and mixtures thereof.

31. The mask pack 1 of claim 28 or 29, wherein the water-soluble polyhydroxy polymer is hydroxyethyl cellulose or hydroxypropyl cellulose or a mixture thereof, and the at least one hydroxyl-rich fiber is selected from the group consisting of viscose, modal, lyocell, cuprammonium, cotton, and mixtures thereof.