CN102940583A - Thermosensitive hydrogel capable of being used as nutrition mask and preparation method of thermosensitive hydrogel - Google Patents
Thermosensitive hydrogel capable of being used as nutrition mask and preparation method of thermosensitive hydrogel Download PDFInfo
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- CN102940583A CN102940583A CN2012104858046A CN201210485804A CN102940583A CN 102940583 A CN102940583 A CN 102940583A CN 2012104858046 A CN2012104858046 A CN 2012104858046A CN 201210485804 A CN201210485804 A CN 201210485804A CN 102940583 A CN102940583 A CN 102940583A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 235000016709 nutrition Nutrition 0.000 title abstract description 6
- 230000035764 nutrition Effects 0.000 title abstract description 4
- 239000000463 material Substances 0.000 claims abstract description 24
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 19
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 18
- 229920001661 Chitosan Polymers 0.000 claims abstract description 18
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- 108010035532 Collagen Proteins 0.000 claims abstract description 8
- 108010010803 Gelatin Proteins 0.000 claims abstract description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 8
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- 229920000159 gelatin Polymers 0.000 claims abstract description 8
- 235000019322 gelatine Nutrition 0.000 claims abstract description 8
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 8
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 8
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 8
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- 235000010419 agar Nutrition 0.000 claims abstract description 7
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- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 7
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 6
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 3
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Abstract
The invention provides a thermosensitive hydrogel capable of being used as a nutrition mask and a preparation method of the thermosensitive hydrogel and belongs to the field of natural polymer material biological application. According to the thermosensitive hydrogel, good-biocompatibility natural polymer materials of agar, gelatin, sodium carboxymethylcellulose, chitosan, derivatives of the chitosan, alginic acid, derivatives of the aloginic acid, collagen, hyaluronic acid, derivatives of the hyaluronic acid, glycerol and the like are used as hydrogel raw materials, proportionally dissolved in water, stirred to form a uniform solution or an emulsion, poured into a mask mold, and then placed in a 60Co-gamma industrial irradiation device to be irradiated with the adsorbed dose of 5kGy-60kGy to synthesize the thermosensitive hydrogel. The preparation method is simple, heating is not required, and the raw materials are not required to be specially treated before irradiation. The thermosensitive hydrogel is good in biocompatibility, water-soluble skin nutrition materials can be accordingly released, and good skin care effects are achieved.
Description
Technical field
The present invention relates to a kind of temperature-sensitive hydrogel that can be used as nourishing pack and preparation method thereof, for the synthetic hydrogel of natural macromolecular material, belong to natural macromolecular material cosmetic applications field.
Background technology
At present, the beauty mask of market popularity mainly is as base material take non-woven fabrics, paper, cotton, dipping facial mask liquid and forming can directly be used, and direct docile is in health a part during use, osmosis along with facial mask liquid, contained facial mask liquid acts on Person's skin, promotes cutaneous circulation, strengthens the epidermis cell vigor, moisten and skin nutrition, reach the effect that improves skin quality.But be face mask substrate material with non-woven fabrics, paper, cotton etc., except playing carrier function, do not possess beauty functions.Because the base material adsorptivities such as non-woven fabrics, paper, cotton are not strong, liquid content is not high in the facial film.Simultaneously, contained facial mask liquid is easily fixed by base material, can't all act on skin surface, and these base materials also exist and contact skin not docile, the problem such as uncomfortable, and it is not high to cause this class facial film to be worth.
Hydrogel is that some high polymers or copolymer absorb the semisolid that large quantity of moisture, swell cross form, and has good physicochemical property and biological property.Hydrogel has good hydrophilic, and very strong swelling ability is arranged in water, but water insoluble.Hydrogel is in use located solvent swelling state, and is quite soft, and has caoutchouc elasticity, the machinery that can reduce peripheral cell and tissue collides and stimulation, simultaneously to skin without adhesion, tear off without sense of discomfort, can be used as the raw material of desirable human body skin nursing.
Existing hydrogel preparation method mostly is chemical synthesis, and needing to add under higher temperature cross-linking agent could the synthetic water gel.But there is toxicity in a lot of cross-linking agent commonly used to human body and environment.On the hydrogel material choice, natural macromolecular material because of its good biocompatibility, wide material sources, can regenerate in a large number, can be by bacterial degradation, be difficult for causing the good characteristics such as white pollution to become study hotspot, but the chemical crosslinkings such as most natural macromolecular materials such as polysaccharide, protide are difficult, are difficult to the synthetic stable cosmetic water gel of character.Synthetic polymer is strong because of activity, is easy to the synthetic water gel under the cross-linking agent effect, so the multiselect synthetic polymer is the hydrogel raw material, but synthetic polymer is toxic to human body and environment greatly, easily to human body and environment and injury.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of temperature-sensitive hydrogel that can be used as nourishing pack.
[0006] the technical problem to be solved in the present invention provides a kind of preparation method that can be used as the temperature-sensitive hydrogel of nourishing pack.
A kind of temperature-sensitive hydrogel that can be used as nourishing pack of the present invention is characterized in that said composition is composed of the following components by weight percentage:
Agar 0%～15%
Gelatin 2%～20%
Sodium carboxymethyl cellulose 1%～15%
Chitosan and derivant 0.1%～5% thereof
Alginic acid and derivant 0%～20% thereof
Collagen protein 0.01%～10%
Hyaluronic acid and derivant 0.01%～5% thereof
Other natural macromolecular materials 0%～6%
Glycerol 0%～4%
All the other are water.
Described chitosan and derivant thereof are chitosan or using carboxyl chitosan.
Described alginic acid and derivant thereof are alginic acid, potassium alginate or sodium alginate.
Described alginic acid and derivant thereof are sodium alginate.
Described hyaluronic acid and derivant thereof are hyaluronic acid, hyaluronate sodium, Curiosin or calcium hyauronate.
Described hyaluronic acid and derivant thereof are hyaluronic acid or hyaluronate sodium.
Described other natural macromolecular materials are carrageenan, cyclodextrin or Rhizoma amorphophalli powder.
A kind of preparation method that can be used as the temperature-sensitive hydrogel of nourishing pack of the present invention may further comprise the steps successively:
(a) form according to raw material and ratio agar, gelatin, sodium carboxymethyl cellulose and derivant thereof, chitosan and derivant thereof, alginic acid and derivant thereof, collagen protein, hyaluronic acid and derivant thereof, glycerol, other natural macromolecular materials are soluble in water, stir, make homogeneous solution or emulsion;
(b) homogeneous solution or the emulsion with preparation is filled with in the cosmetics mould encapsulated moulding; Put into
60In the Co-γ industrial irradiation device, be to carry out irradiation, crosslinked synthetic water gel under 5kGy～60kGy in absorbed dose.
Above-mentioned hydrogel feedstock composition, each component requires good water solubility.
In above-mentioned hydrogel feedstock composition, preferred chitosan and derivant thereof are selected from chitosan or using carboxyl chitosan.
In above-mentioned hydrogel feedstock composition, preferred alginic acid and derivant thereof are selected from alginic acid, potassium alginate or sodium alginate, wherein sodium alginate most preferably.
In above-mentioned hydrogel feedstock composition, hyaluronic acid and derivant thereof are selected from hyaluronic acid, hyaluronate sodium, Curiosin and calcium hyauronate.Wherein most preferably hyaluronic acid or hyaluronate sodium.
In above-mentioned hydrogel feedstock composition, preferably other natural macromolecular materials are carrageenan, cyclodextrin or Rhizoma amorphophalli powder.
A kind of temperature-sensitive hydrogel that can be used as nourishing pack of the present invention, with nontoxic, harmless, good biocompatibility, natural macromolecular material natural macromolecular material agar, gelatin, sodium carboxymethyl cellulose, chitosan and derivant, alginic acid and derivant thereof with certain health care, skin-protecting function, collagen protein, hyaluronate sodium, glycerol, other natural macromolecular materials etc. as the hydrogel raw material, irradiation synthetic water gel.This class hydrogel not only itself possesses good skin nursing effect, also has strong absorbability, can absorb moisture and load the more beautifying nourishing factor, and then be prepared into the multiclass product of the comprehensive restoration care of human body skin.Hydrogel provided by the invention is temperature-sensitive hydrogel, and in 10 ℃～50 ℃ temperature ranges, such hydrogel is along with temperature raises, and its suction saturation reduces, and moisture disengages from gel inside.Like this, the nutritional labeling in the film acts on the skin except the osmosis by film itself, can also disengage along with disengaging of moisture, and then act on skin, has improved greatly the utilization rate of nutritional labeling, has played good skin care effect.
Preparation method utilization of the present invention
60Co-gamma-rays effect synthetic water gel, synthesis and preparation process is simple, is easy to suitability for industrialized production.
60The Co-gamma-rays has strong penetrance, and preparative capacibility is strong,, can to the hydrogel sterilization that carries out disinfection, be the hydrogel synthetic method of a kind of safety, environmental protection in the time of crosslinked synthetic water gel.
Beneficial effect of the present invention has:
(a) such hydrogel synthesis technique is simple, strong operability, and energy consumption is low.Predose, raw material only need stir at normal temperatures, do not need extra other processing, and irradiation process need not made heat treated.
(b) synthetic hydrogel stable performance, the environmental changes such as the temperature in the building-up process, humidity are minimum to the performance impact of hydrogel, also can not affect its combined coefficient and properties of product when temperature is low.
(c) radiation sterilization and crosslinked synthesizing finish together in the preparation process.Because
60Co-γ irradiation sterilization method is to have sterilizing methods very ripe, safety non-pollution now, in the synthetic water gel, has also finished the sterilization of hydrogel.
(d) hydrogel building-up process
60It is crosslinked that the Co-gamma-rays causes the hydrogel raw material, need not add any cross-linking agent, further reduced the impact of poisonous and harmful chemical compound.
(e) raw material of selecting and synthesis technique are not introduced poisonous and harmful substance, and synthetic hydrogel good biocompatibility is beneficial to environment sustainable development.
Description of drawings
Fig. 1 is the photo of application examples of the present invention;
Fig. 2 is the photo of further application of the invention example.
The specific embodiment
Embodiment 1
Under room temperature and normal pressure, each component that clicks respectively appointment in the table 1 is soluble in water with gelatin, sodium carboxymethyl cellulose, using carboxyl chitosan, collagen protein, stirs and forms homogeneous solution or emulsion, according to needing the mould of preparation difformity, different-thickness.Material solution is poured in the mould, and encapsulated moulding is put into radiation chamber irradiation 15 kGy～60 kGy, the synthetic water gel.
Fig. 1 is the photo of application examples of the present invention, and a kind of temperature-sensitive hydrogel that can be used as nourishing pack of the present invention's preparation sticks on photo on hand, and it is round that this hydrogel is made mould, and thickness is 3mm.
Fig. 2 is the photo of further application of the invention example.A kind of temperature-sensitive hydrogel that can be used as nourishing pack of the present invention's preparation sticks on photo on hand.
Embodiment 2
Each constituent content of pressing the appointment in the following table 1 repeats the method for embodiment 1, but selected component and weight content thereof are different.
Embodiment 3
Each constituent content of pressing the appointment in the following table 1 repeats the method for embodiment 1, but selected component and weight content thereof are different.
Embodiment 4
Each constituent content of pressing the appointment in the following table 1 repeats the method for embodiment 1, but selected component and weight content thereof are different.
Embodiment 5
Each constituent content of pressing the appointment in the following table 1 repeats the method for embodiment 1, but selected component and weight content thereof are different.
Embodiment 6
Each constituent content of pressing the appointment in the following table 1 repeats the method for embodiment 1, but selected component and weight content thereof are different.
Embodiment 7
Each constituent content of pressing the appointment in the following table 1 repeats the method for embodiment 1, but selected component and weight content thereof are different.
Embodiment 8
Each constituent content of pressing the appointment in the following table 1 repeats the method for embodiment 1, but selected component and weight content thereof are different.
Table 1
| Each constituent content (weight portion) and heavy metal adsorption | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 |
| Agar | ? | ? | 1% | 2% | ? | 0.3% | ? | 0.3% |
| Gelatin | 3% | 3.5% | 6% | 4% | 10% | 15% | 8% | 11% |
| Sodium carboxymethyl cellulose | 1.5% | ? | 0.3% | 10% | 3% | 2% | 4% | 1% |
| Chitosan and derivant thereof | 1% | ? | 0.2% | ? | ? | 4% | 3% | 1% |
| Alginic acid and derivant thereof | ? | 0.6% | ? | 0.1% | ? | 1% | 2% | 6% |
| Collagen protein | 0.1% | 0.1% | 0.2% | 0.2% | ? | 0.2% | ? | 2% |
| Hyaluronic acid and derivant thereof | ? | ? | ? | 1% | 4% | 3% | 1% | 2% |
| Other natural macromolecular materials | ? | 1% | ? | ? | ? | ? | 0.2% | 1% |
| Glycerol | ? | ? | ? | 0.1% | ? | 0.2% | ? | 0.01% |
Claims (8)
1. temperature-sensitive hydrogel that can be used as nourishing pack is characterized in that said composition is composed of the following components by weight percentage:
Agar 0%～15%
Gelatin 2%～20%
Sodium carboxymethyl cellulose 1%～15%
Chitosan and derivant 0.1%～5% thereof
Alginic acid and derivant 0%～20% thereof
Collagen protein 0.01%～10%
Hyaluronic acid and derivant 0.01%～5% thereof
Other natural macromolecular materials 0%～6%
Glycerol 0%～4%
All the other are water.
2. the temperature-sensitive hydrogel that can be used as nourishing pack according to claim 1, it is characterized in that: described chitosan and derivant thereof are chitosan or using carboxyl chitosan.
3. the temperature-sensitive hydrogel that can be used as nourishing pack according to claim 1, it is characterized in that: described alginic acid and derivant thereof are alginic acid, potassium alginate or sodium alginate.
4. the temperature-sensitive hydrogel that can be used as nourishing pack according to claim 1, it is characterized in that: described alginic acid and derivant thereof are sodium alginate.
5. the temperature-sensitive hydrogel that can be used as nourishing pack according to claim 1, it is characterized in that: described hyaluronic acid and derivant thereof are hyaluronic acid, hyaluronate sodium, Curiosin or calcium hyauronate.
6. the temperature-sensitive hydrogel that can be used as nourishing pack according to claim 1, it is characterized in that: described hyaluronic acid and derivant thereof are hyaluronic acid or hyaluronate sodium.
7. the temperature-sensitive hydrogel that can be used as nourishing pack according to claim 1, it is characterized in that: described other natural macromolecular materials are carrageenan, cyclodextrin or Rhizoma amorphophalli powder.
8. preparation method that can be used as the temperature-sensitive hydrogel of nourishing pack is characterized in that may further comprise the steps successively:
(a) form according to raw material and ratio agar, gelatin, sodium carboxymethyl cellulose and derivant thereof, chitosan and derivant thereof, alginic acid and derivant thereof, collagen protein, hyaluronic acid and derivant thereof, glycerol, other natural macromolecular materials are soluble in water, stir, make homogeneous solution or emulsion;
(b) homogeneous solution or the emulsion with preparation is filled with in the cosmetics mould encapsulated moulding; Put into
60In the Co-γ industrial irradiation device, be to carry out irradiation, crosslinked synthetic water gel under 5kGy～60kGy in absorbed dose.
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| CN201210485804.6A CN102940583B (en) | 2012-11-26 | 2012-11-26 | Thermosensitive hydrogel capable of being used as nutrition mask and preparation method of thermosensitive hydrogel |
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| CN103751033A (en) * | 2014-01-15 | 2014-04-30 | 青岛海蓝生物制品有限公司 | Preparation method of makeup removal hydrating mask capable of removing heavy metal |
| CN104027293A (en) * | 2014-06-27 | 2014-09-10 | 王忠良 | Whitening cosmetic and preparation method thereof |
| CN104107147A (en) * | 2013-04-17 | 2014-10-22 | 北京中天神舟航天食品技术研究院 | High-safety edible beauty mask and preparation method thereof |
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| CN105288700A (en) * | 2015-11-26 | 2016-02-03 | 西南大学 | Medical thermo-sensitive hydrogel dressing and preparation method thereof |
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Inventor after: Yang Guixia Inventor after: Li Xiaoyan Inventor after: Wu Xiaoli Inventor after: An You Inventor after: Liu Xuqiang Inventor after: Yu Xiangzhong Inventor after: Zeng Fansong Inventor after: Pang Yuanlong Inventor after: Huang Wei Inventor after: Li Zongjun Inventor after: Jiang Shubin Inventor before: Yang Guixia Inventor before: Li Xiaoyan Inventor before: Wu Xiaoli Inventor before: An You Inventor before: Liu Xuqiang Inventor before: Yu Xiangzhong Inventor before: Zeng Fansong Inventor before: Pang Yuanlong Inventor before: Huang Wei Inventor before: Li Zongjun Inventor before: Jiang Shubin |
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