CN113015716A - 用作增香剂的乙酸酯化合物 - Google Patents
用作增香剂的乙酸酯化合物 Download PDFInfo
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- CN113015716A CN113015716A CN201880099475.7A CN201880099475A CN113015716A CN 113015716 A CN113015716 A CN 113015716A CN 201880099475 A CN201880099475 A CN 201880099475A CN 113015716 A CN113015716 A CN 113015716A
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- China
- Prior art keywords
- methyl
- cyclopropyl
- compound
- trimethylbicyclo
- carbon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001242 acetic acid derivatives Chemical class 0.000 title abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 28
- 150000001875 compounds Chemical class 0.000 claims description 30
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 21
- -1 1-methyl-2-((1,2,2-trimethylbicyclo[3.1.0]hex-3-yl)methyl)cyclopropane acetic acid Chemical compound 0.000 claims description 14
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 14
- 239000004615 ingredient Substances 0.000 claims description 14
- 150000001721 carbon Chemical group 0.000 claims description 9
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 239000001257 hydrogen Substances 0.000 claims description 6
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- OAKFACUIGQLOCA-SEOXFTARSA-N [1-methyl-2-[[(1s,3r,5r)-1,2,2-trimethyl-3-bicyclo[3.1.0]hexanyl]methyl]cyclopropyl]methanol Chemical compound OCC1(C)CC1C[C@@H]1C(C)(C)[C@@]2(C)C[C@H]2C1 OAKFACUIGQLOCA-SEOXFTARSA-N 0.000 claims description 4
- OAKFACUIGQLOCA-UHFFFAOYSA-N [1-methyl-2-[(1,2,2-trimethyl-3-bicyclo[3.1.0]hexanyl)methyl]cyclopropyl]methanol Chemical compound OCC1(C)CC1CC1C(C)(C)C2(C)CC2C1 OAKFACUIGQLOCA-UHFFFAOYSA-N 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
- C11B9/0042—Essential oils; Perfumes compounds containing condensed hydrocarbon rings
- C11B9/0046—Essential oils; Perfumes compounds containing condensed hydrocarbon rings containing only two condensed rings
- C11B9/0049—Essential oils; Perfumes compounds containing condensed hydrocarbon rings containing only two condensed rings the condensed rings sharing two common C atoms
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- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/12—Acetic acid esters
- C07C69/14—Acetic acid esters of monohydroxylic compounds
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- C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
- C11B9/00—Essential oils; Perfumes
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- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/18—All rings being cycloaliphatic the ring system containing six carbon atoms
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Abstract
本发明涉及具有木香乳脂样檀香气味特性的乙酸酯。本发明还涉及包含它们的香料组合物和消费品。
Description
本发明涉及具有木香乳脂样檀香嗅觉特性的新型增香剂。本发明还涉及它们的生产方法，以及包含它们的香料组合物。
在香料和香精工业中，香料制造商和调香师持续寻求新的化合物。
令人惊奇地，我们目前已经发现一类新的乙酸酯，其具有木香乳脂样檀香气味特征。
在第一个实施方案中，提供了式(I)的化合物
其中
R1和R2与它们所连接的碳原子一起形成环丙基或双键，或R1和R2为氢；且
R3和R4与它们所连接的碳原子一起形成环丙基或双键，且虚线与碳-碳键一起形成单键；或
R3和R4为氢，且虚线与碳-碳键一起形成双键。
式(I)的化合物包含一个或多个手性中心，且照此可以以立体异构体的混合物形式存在，或者可以将它们拆分为异构体纯形式。
拆分立体异构体增加了这些化合物的制备和纯化的复杂性，因此单纯出于经济原因，优选将化合物作为其立体异构体的混合物使用。然而，如果期望制备单独的立体异构体，则可以根据本领域已知的方法，例如通过制备型HPLC和GC、结晶或立体选择性合成来实现这一目的。
作为式(I)的化合物的具体实例，可以举出乙酸(1-甲基-2-((1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲酯作为非限制性实例，其具有温和的木香乳脂样檀香香质与温和的果香花香香调(紫罗兰/鸢尾方向(direction))。该化合物的所有四种非对映异构体均有助于其总体气味特征，但仅发现一种非对映异构体构成主要的气味载体(rel-(1S,2S)-(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)-环丙基)甲醇)。
此外，非限制性实例为式(I)的化合物，其选自：
乙酸(E)-2-甲基-4-(1,2,2-三甲基二环[3.1.0]己-3-基)丁-2-烯-1-基酯；
乙酸(E)-2-甲基-4-(1,2,2-三甲基二环[3.1.0]己-3-基)丁-3-烯-1-基酯，
乙酸(E)-2-甲基-4-(2,2,3-三甲基环戊基)丁-3-烯-1-基酯；
乙酸(E)-2-甲基-4-(2,2,3-三甲基环戊基)丁-2-烯-1-基酯；
乙酸(E)-2-甲基-4-(2,2,3-三甲基环戊-3-烯-1-基)丁-3-烯-1-基酯；
乙酸(E)-2-甲基-4-(2,2,3-三甲基环戊-3-烯-1-基)丁-2-烯-1-基酯；
乙酸(1-甲基-2-((2,2,3-三甲基环戊-3-烯-1-基)甲基)环丙基)甲酯；和
乙酸(1-甲基-2-((2,2,3-三甲基环戊基)甲基)环丙基)甲酯。
式(I)的化合物可以单独使用，或可以作为立体异构体混合物使用，或可以与已知的增香剂分子联用，所述增香剂分子选自广泛范围的天然产物和目前可利用的合成分子，例如精油，醇类，醛类和酮类，醚类和缩醛类，酯类和内酯类，大环类和杂环类，和/或与通常与香料组合物中的增香剂一起使用的一种或多种成分或赋形剂的混合物，例如，载体材料和本领域常用的其他助剂。
如本文所用，“载体材料”是指从增香剂的观点来看实际上是中性的材料，即不会显著改变增香剂感官特性的材料。
术语“助剂”是指出于与所述组合物的嗅觉性能没有特别关系的原因而可用于香料组合物中的成分，例如，助剂可以为用作加工香料成分或多种成分的助剂的成分，或含有所述成分的组合物，或它可以改善香料成分或含有该成分的组合物的处理或储存，它也可以是提供额外益处(例如赋予颜色或质地)的成分。也可以为对包含在香料组合物中的一种或多种成分赋予耐光性或化学稳定性的成分。在包含香料的香料组合物中常用的助剂的性质和类型的详细描述不能穷尽，但必须提及的是，所述成分对于本领域技术人员而言是众所周知的。
如本文所用，“香料组合物”是指包含式(I)的化合物和基质材料的任何组合物，所述基质材料例如为通常与增香剂结合使用的稀释剂，例如邻苯二甲酸二乙酯(DEP)，一缩二丙二醇(DPG)，肉豆蔻酸异丙酯(IPM)，戊-1,2-二醇，柠檬酸三乙酯(TEC)和醇(例如乙醇)。任选地，该组合物可以包含抗氧化剂助剂。所述抗氧化剂可以选自
TT(BASF)、
Q(BASF)、生育酚(包括其异构体，CAS 59-02-9；364-49-8；18920-62-2；121854-78-2)、2,6-双(1,1-二甲基乙基)-4-甲基苯酚(BHT，CAS 128-37-0)和相关的酚类，氢醌类(CAS 121-31-9)。
下列清单包含已知增香剂分子的实例，其可以与式(I)的化合物合并：
-精油和提取物，例如，海狸，木香根油，橡苔净油，香叶油，树苔净油，罗勒油，果油如香柠檬油和橘子油，香桃木油，玫瑰草油，广藿香油，橙叶油，茉莉油，玫瑰油，檀香油，苦艾油，熏衣草油和/或依兰-依兰油；
-醇类，例如肉桂醇((E)-3-苯基丙-2-烯-1-醇)；顺式-3-己烯醇((Z)-己-3-烯-1-醇)；香茅醇(3,7-二甲基辛-6-烯-1-醇)；二氢月桂烯醇(2,6-二甲基辛-7-烯-2-醇)；EbanolTM((E)-3-甲基-5-(2,2,3-三甲基环戊-3-烯-1-基)戊-4-烯-2-醇)；丁香酚(4-烯丙基-2-甲氧基苯酚)；乙基芳樟醇((E)-3,7-二甲基壬-1,6-二烯-3-醇)；金合欢醇((2E,6Z)-3,7,11-三甲基十二碳-2,6,10-三烯-1-醇)；香叶醇((E)-3,7-二甲基辛-2,6-二烯-1-醇)；Super MuguetTM((E)-6-乙基-3-甲基辛-6-烯-1-醇)；芳樟醇(3,7-二甲基辛-1,6-二烯-3-醇)；薄荷醇(2-异丙基-5-甲基环己醇)；橙花醇(3,7-二甲基-2,6-辛二烯-1-醇)；苯乙醇(2-苯乙醇)；RhodinolTM(3,7-二甲基辛-6-烯-1-醇)；SandaloreTM(3-甲基-5-(2,2,3-三甲基环戊-3-烯-1-基)戊-2-醇)；松油醇(2-(4-甲基环己-3-烯-1-基)丙-2-醇)；或TimberolTM(1-(2,2,6-三甲基环己基)己-3-醇)；2,4,7-三甲基辛-2,6-二烯-1-醇；和/或[1-甲基-2(5-甲基己-4-烯-2-基)环丙基]-甲醇；
-醛类和酮类，例如茴香醛(4-甲氧基苯甲醛)；α戊基肉桂醛(2-亚苄基庚醛)；GeorgywoodTM(1-(1,2,8,8-四甲基-1,2,3,4,5,6,7,8-八氢萘-2-基)乙酮)；羟基香茅醛(7-羟基-3,7-二甲基辛醛)；Iso E 
(1-(2,3,8,8-四甲基-1,2,3,4,5,6,7,8-八氢萘-2-基)乙酮)；
((E)-3-甲基-4-(2,6,6-三甲基环己-2-烯-1-基)丁-3-烯-2-酮)；
(3-氧代-2-戊基环戊烷乙酸甲酯)；3-(4-异丁基-2-甲基苯基)丙醛；麦芽酚；甲基柏木基酮；甲基紫罗兰酮；马鞭草烯酮；和/或香草醛；
-醚类和缩醛类，例如
(3a,6,6,9a-四甲基-2,4,5,5a,7,8,9,9b-八氢-1H-苯并[e][1]苯并呋喃)；香叶基甲基醚((2E)-1-甲氧基-3,7-二甲基辛-2,6-二烯)；玫瑰醚(4-甲基-2-(2-甲基丙-1-烯-1-基)四氢-2H-吡喃)；和/或
(2',2',3,7,7-五甲基螺[二环[4.1.0]庚烷-2,5'-[1,3]二噁烷])；
-酯类和内酯类，例如乙酸苄酯；乙酸柏木酯(乙酸(1S,6R,8aR)-1,4,4,6-四甲基八氢-1H-5,8a-亚甲基甘菊环-6-基酯)；γ-癸内酯(6-戊基四氢-2H-吡喃-2-酮)；
(丙酸2-(1-(3,3-二甲基环己基)乙氧基)-2-甲基丙酯)；γ-十一烷酸内酯(5-庚基氧杂戊环-2-酮)；和/或乙酸岩兰草酯(乙酸(4,8-二甲基-2-丙-2-亚基-3,3a,4,5,6,8a-六氢-1H-甘菊环-6-基)酯)；
-大环内酯类，例如黄葵内酯((Z)-氧杂环十七碳-10-烯-2-酮)；十三烷二酸亚乙基酯(1,4-二氧杂环十七烷-5,17-二酮)；和/或
(16-氧杂环十六烷-1-酮)；和
-杂环类，例如异丁基喹啉(2-异丁基喹啉)。
在一个具体的实施方案中，式(I)的化合物可以与其他已知的木香增香剂例如JavanolTM(1-甲基-2-[[(1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基]甲基]环丙烷甲醇)、EbanolTM((E)-3-甲基-5-(2,2,3-三甲基-3-环戊烯-1-基)-4-戊烯-2-醇、RadjanolTM(2-乙基-4-(2,2,3-三甲基-3-环戊烯-1-基)-2-丁烯-1-醇)、PolysantolTM(3,3-二甲基-5-(2,2,3-三甲基-3-环戊烯-1-基)-4-戊烯-2-醇、OsyrolTM(3,7-二甲基-7-甲氧基-2-辛醇)、SandaloreTM(3-甲基-5-(2,2,3-三甲基环戊-3-烯-1-基)戊-2-醇)、SandelaTM(3-(5,5,6-三甲基二环[2.2.1]庚-2-基)环己-1-醇)、PolysantTM(3,3-二甲基-5-(2,2,3-三甲基-3-环戊烯-1-基)-4-戊烯-2-醇)等合并以增强天然木香特性。
在某些实施方案中，式(I)的化合物可以与其他木香增香剂合并，其范围为0.05:99.95至99.95:0.05(例如其范围为0.5:99.5至5:95(式(I)的化合物或其混合物:木香增香剂))。
在一个具体的实施方案中，式(I)的化合物为乙酸(1-甲基-2-((1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)甲酯，而其他的木香增香剂为(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)-环丙基)甲醇，其组合范围为0.05:99.95至99.95:0.05(例如其范围为0.1:99.5至5:95(包括0.2:99.8；0.3:99.7；0.4:99.6)。
在另一个具体的实施方案中，式(I)的化合物为乙酸(1-甲基-2-(1S,3R,5R)-((1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)甲酯，而其他的木香增香剂为(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)-环丙基)甲醇，其组合范围为0.05:99.95至99.95:0.05(例如其范围为0.1:99.5至5:95(包括0.2:99.8；0.3:99.7；0.4:99.6；0.5:99.5；0.6:99.4；0.7:99.3；0.8:99.2；0.9:99.1；1:99；1.5:98.5)。
式(I)的化合物可以通过在本领域技术人员众所周知的条件下使相应的醇乙酰化来制备。相应醇的制备描述在例如EP0801049中。
任选地，式(I)的化合物，其中R1和R2与它们所连接的碳原子一起形成环丙基和/或R3和R4与它们所连接的碳原子一起形成环丙基，环丙烷化和乙酰化二者可以在单罐法中在锌和例如乙酰氯存在下进行。醇与乙酸酯之比由所用的试剂的量和适当选择的粗产物的蒸馏级分控制。
现在参考下文的非限制性实施例进一步描述本发明。这些实施例仅出于示例目的，并且应当理解，本领域的技术人员可以做出变化和变型。
实施例1：乙酸(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)甲酯
在氮气气氛中向带有回流冷凝器的反应器中加入1-甲基-2-[[(1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基]甲基]环丙烷甲醇)(非对映异构体的混合物；异构体1：40.9％；异构体2：53.4％；50g；纯度：94.3％；212mmol)、吡啶(20g；253mmol)和甲苯(200g)。在0℃向搅拌的该混合物中滴加乙酰氯(18g；229mmol)，历时15分钟。使得到的反应混合物升至20℃，再搅拌2小时。加入水。分离有机层，洗涤(水)，通过旋转蒸馏浓缩(60℃；10mbar)，得到58g淡黄色油状物，其包含90％的乙酸(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲酯。再通过使用15cm Vigreux柱在0.08托下蒸馏进一步纯化，得到48g(纯度：93.9％；异构体1：41.4％；异构体2：52.5％；170mmol)的乙酸(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲酯。再从8.7g弃去的级分(82％纯)中回收产物。基于(1-甲基-2-(1,2,2-三甲基双环(3.1.0)己-3-基甲基)环丙基)甲醇的乙酸(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)-基于环丙基)甲酯摩尔收率为约80％，未考虑弃去的级分。将第二次蒸馏后得到的48g进一步使用Sulzer柱(20cm)蒸馏，得到40g的98％(异构体1：43.2％；异构体2：54.8％)的嗅觉纯的产物(乙酸(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)甲酯)。
气味描述：温和的，木香乳脂样檀香香质，带有温和的果香花香香调(紫罗兰/鸢尾方向)。
异构体1(rel-乙酸(1R,2R)-(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)甲酯)：1H NMR(C6D6，600MHz)：
3.83(d，J＝11.3，1H)，3.77(d，J＝10.9，1H)，1.95(dd，J＝12.4，6.4，1H)，1.73(s，3H)，1.37(td，J＝11.7，4.1，1H)，1.22-1.16(m，2H)，1.04(s，3H)，1.03(s，3H)，1.01-0.93(m，2H)，0.92(s，3H)，0.74(s，3H)，0.55-0.47(m，3H)，0.08(dd，J＝7.5，4.5，1H)，-0.13(brt，J＝4.5，1H)。
13C NMR(C6D6，150MHz)：170.0，73.2，45.1，41.1，32.4，31.2，29.5，22.8，22.75，21.4，20.3，19.5，18.7，17.4，17.3，15.3，14.0。
异构体2(rel-乙酸(1S,2S)-(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)甲酯)：1H NMR(C6D6，600MHz)：3.84(d，J＝11.3，1H)，3.79(d，J＝10.9，1H)，1.88(dd，J＝12.1，6.8，1H)，1.72(s，3H)，1.37(td，J＝11.7，4.1，1H)，1.22-1.13(m，2H)，1.09-1.06(m，1H)，1.04(s，3H)，1.04(s，3H)，1.00-0.97(m，1H)，0.93(s，3H)，0.74(s，3H)，0.54-0.47(m，3H)，0.06(dd，J＝7.9，4.9，1H)，-0.18(br t，J＝4.5，1H)。
13C NMR(C6D6，150MHz)：170.0，73.2，44.8，41.1，32.2，31.3，28.8，22.8，22.6，21.9，20.2，19.6，19.6，17.2，16.8，15.9，13.9。
实施例2：木香，东方香料谐香
用乙酸(1-甲基-2-((1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲酯(即式(I)的化合物)替代4份上述谐香的DPG可以使所述谐香在新鲜和干燥后均温和，且特别是可以给干燥后的香型带来温和的乳脂样鸢尾紫罗兰香味。
用乙酸(1-甲基-2-((1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲酯和(1-甲基-2-((1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲醇的混合物(2:98之比)替代20份上述谐香的DPG，醇递送了性能和整体檀香香质，与乙酸酯组合可使其温和，具有一般的檀香香质，其显得更自然，更接近檀香精油的效果和香质，具有温和的果香花香的鸢尾方面(facet)。
Claims (10)
1.式(I)的化合物，为其立体异构体的任意一种或其混合物的形式，
其中
R1和R2与它们所连接的碳原子一起形成环丙基或双键，或R1和R2为氢；且
R3和R4与它们所连接的碳原子一起形成环丙基或双键，且虚线与碳-碳键一起形成单键；或
R3和R4为氢，且虚线之一与所连接的碳-碳键形成双键。
2.权利要求1的化合物，其中R1和R2和/或R3和R4与它们所连接的碳原子一起形成环丙基。
3.权利要求2的化合物，其中该化合物为乙酸(1-甲基-2-((1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲酯，为其立体异构体的任意一种或其混合物的形式。
4.权利要求3的化合物，其中该化合物为乙酸(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲酯。
5.香料组合物，包含下列成分或由下列成分组成：
a)至少一种如权利要求1或2中所定义的式(I)的化合物，和
b)[1-甲基2-[(1,2,2-三甲基二环[3.1.0]己-3-基)甲基]环丙基]甲醇，为其立体异构体的任意一种或其混合物的形式。
6.权利要求5的香料组合物，其中式(I)的化合物为乙酸(1-甲基-2-(((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基)环丙基)-甲酯(成分a))，且成分b)为[1-甲基2-[((1S,3R,5R)-1,2,2-三甲基二环[3.1.0]己-3-基)甲基]环丙基]甲醇。
7.权利要求5或权利要求6的香料组合物，其特征在于成分a)与b)的重量比在0.05:99.95至5:95(a:b)的范围。
8.消费品，包含如权利要求1中所定义的式(I)的化合物或如权利要求5、权利要求6或权利要求7中所定义的香料组合物和消费品基质。
9.式(I)的化合物作为香料的用途，
其中
R1和R2与它们所连接的碳原子一起形成环丙基或双键，或R1和R2为氢；且
R3和R4与它们所连接的碳原子一起形成环丙基或双键，且虚线与碳-碳键一起形成单键；或
R3和R4为氢，且虚线之一与所连接的碳-碳键形成双键。
10.改善、增强或改变消费品基质的方法，通过向其中添加嗅觉可接受量的如权利要求1所定义的式(I)的化合物或如权利要求3-5之一中所定义的香料组合物来进行。
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