CN112956601A - 25-hydroxy vitamin D3Application in improving piglet quality - Google Patents
25-hydroxy vitamin D3Application in improving piglet quality Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/30—Feeding-stuffs specially adapted for particular animals for swines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/60—Feeding-stuffs specially adapted for particular animals for weanlings
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Birds (AREA)
- Fodder In General (AREA)
Abstract
本发明提供一种25‑羟基维生素D3在提高仔猪品质中的应用，该应用在以下至少一方面：1)提高仔猪生长性能，2)提高仔猪机体免疫水平，3)提高仔猪机体抗氧化能力，4)提高仔猪骨品质，5)制备仔猪饲料，所述25‑羟基维生素D3的应用对象为断奶仔猪。本发明将25‑羟基维生素D3应用于断奶仔猪，能够显著提高断奶仔猪生长后期和全期平均日增重，增加仔猪血清免疫球蛋白含量、过氧化氢酶活性、骨特异性碱性磷酸酶和骨钙素含量。The invention provides an application of 25-hydroxyvitamin D 3 in improving piglet quality. The application is at least one of the following aspects: 1) improving the growth performance of piglets, 2) improving the immune level of piglets, and 3) improving the antioxidant capacity of piglets , 4) improve piglet bone quality, 5) prepare piglet feed, and the application object of described 25-hydroxyvitamin D 3 is weaned piglets. The invention applies 25-hydroxyvitamin D 3 to weaned piglets, which can significantly improve the average daily weight gain of the weaned piglets in the late growth stage and the whole period, and increase the serum immunoglobulin content, catalase activity and bone-specific alkaline phosphatase of piglets. and osteocalcin content.
Description
Technical Field
The invention relates to the field of feed additives, in particular to 25-hydroxy vitamin D3Application in improving piglet quality.
Background
Under modern intensive culture conditions, the growth speed of piglets is high, the development and mineralization of bones are closely related to the storage of calcium and phosphorus, and are directly influenced by the daily ration level of the piglets, for example, the formation of the bones is hindered by insufficient content of calcium and phosphorus or improper proportion of the calcium and the phosphorus in the feed, so that the bone quality is reduced. And the pigs are in the environment with poor illumination condition for a long time to influence self vitamin D3Production of, vitamin D3The deficiency can cause the absorption and metabolism disorder of calcium and phosphorus, influence the normal growth and development of bones, and cause rickets in severe cases, thereby reducing the growth speed of pigs and improving the feeding cost. Piglets can become oxidatively stressed after weaning. Study ofThe calcium deficiency can cause the content of antioxidant enzymes such as superoxide dismutase to be obviously reduced, the phosphorus deficiency can reduce the level of reduced glutathione and inhibit the activity of antioxidant enzyme and the expression of related gene mRNA level, so that the oxidative stress reaction of weaned piglets is aggravated by the deficiency of calcium and phosphorus of the daily ration. In addition, the higher calcium phosphorus ration will lower the expression level of proinflammatory factors of pig small intestinal mucosa, such as interleukin-1 beta mRNA, compared with the low calcium phosphorus ration, suggesting that the calcium phosphorus level of the ration is related to the immune function of the organism. Vitamin D3Can regulate the absorption of calcium and phosphorus by small intestine, maintain the optimal serum calcium and phosphorus steady state required by bone mineralization and bone remodeling, and is also related to animal reproductive performance, intestinal mucosa cell differentiation, organism immunity and oxidation resistance, and in vivo virus infection inhibition. In addition, vitamin D3The utilization rate of phytate phosphorus is considered to be improved by increasing the activity of phytase in animal intestinal tracts, and the proposal is that the use amount of exogenous inorganic phosphorus in daily ration can be properly reduced, so that the production cost of the feed is reduced, and the negative environmental influence caused by excessive phosphorus discharge is relieved. Lean-type piglets recommended in pig nutritional requirements (2021) and having 8-25 kg of vitamin D in weight stage3The required amount of 220IU/kg is the minimum nutritional standard for ensuring that deficiency does not occur, and the standard cannot meet the optimal growth, bone strength and special physiological functions of animals such as immunity and the like. In addition, vitamin D is commonly used in production3The biological utilization rate is low, and the requirement of the piglet on quick growth is difficult to meet. Therefore, it is important to find vitamin D additives with higher bioavailability. 25-hydroxy vitamin D3Due to addition of a hydrophilic hydroxyl group, with vitamin D3Has less dependence on fat than vitamin D3More preferably, 1 alpha, 25-dihydroxyvitamin D is used3And is safer. The daily diet is supplemented with 25-hydroxyvitamin D directly, in view of the fact that the liver function of young animals has not yet reached the adult metabolic function level3Hydroxylation reaction bypassing liver to vitamin D3Can be directly utilized by animals in a ready-to-use active form, is more efficiently utilized biologically, and therefore 25-hydroxyvitamin D3May be considered a preferred source of vitamin D for young animals.At present, 25-hydroxyvitamin D is used at home and abroad3The application research is relatively less under the condition that the daily ration calcium and phosphorus content of the weaned pigs is reduced. Therefore, the addition of 25-hydroxy vitamin D to low-calcium and low-phosphorus daily ration is explored3The application mode of the novel feed additive which is a main effective component and can effectively improve the growth performance, the serum immunity level, the oxidation resistance and the bone quality of the pigs has wide market prospect.
Disclosure of Invention
The embodiment of the invention provides 25-hydroxy vitamin D3Application in improving piglet quality. The invention relates to 25-hydroxy vitamin D3The compound premix can be applied to weaned pigs, can obviously improve the average daily gain of the weaned pigs in the later growth period and the whole growth period, and can increase the serum immunoglobulin content, the catalase activity, the bone-specific alkaline phosphatase and the osteocalcin content of the piglets.
The embodiment of the invention provides 25-hydroxy vitamin D3Use in improving piglet quality, said use in at least one aspect of:
1) the growth performance of the piglets is improved;
2) improving the body immunity level of the piglets
3) Improving the oxidation resistance of the piglet organism;
4) the piglet bone quality is improved;
5) preparing a piglet feed;
the 25-hydroxy vitamin D3The application object of (2) is weaned piglets.
In the present invention, the 25-hydroxyvitamin D3The structure of (A) is as follows:
according to the invention, 25-hydroxy vitamin D is added to the low-calcium and low-phosphorus ration after the pigs are weaned3Can obviously improve the average daily gain of the weaned piglets in the later growth period and the whole growth period, and increase the serum immunoglobulin content, the catalase activity, the bone-specific alkaline phosphatase and the osteocalcin content of the piglets, thereby effectively realizingImproves the growth speed, the immunologic function, the oxidation resistance and the bone performance of the pig.
25-hydroxy vitamin D provided according to embodiments of the invention3Application of 25-hydroxy vitamin D in improving piglet quality3The feed for the weaned piglets is added with 45-55 mug of feed in a proportion of 1 kg.
25-hydroxy vitamin D provided according to embodiments of the invention3Application of 25-hydroxy vitamin D in improving piglet quality3Adding the feed additive in the early growth stage and/or the late growth stage of the weaned piglets; preferably, the feed is continuously added in the early growth stage and the later growth stage of the weaned pigs, wherein the weight of the weaned pigs in the early growth stage is 6-9 kg, and the weight of the weaned pigs in the later growth stage is 9-14 kg.
25-hydroxy vitamin D provided according to embodiments of the invention3Application of 25-hydroxy vitamin D in improving piglet quality3The application of the compound feed additive in improving the growth performance, the organism immunity level, the organism oxidation resistance and the bone quality of weaned pigs.
25-hydroxy vitamin D provided according to embodiments of the invention3Use in improving piglet quality, said growth performance comprising increasing average daily gain later in growth and/or throughout; the body immunity level and body antioxidant capacity include increasing serum immunoglobulin content and/or catalase activity; the bone quality comprises increasing serum calcium, bone specific alkaline phosphatase and/or osteocalcin content.
The embodiment of the invention also provides a feed for weaned pigs, which contains low-calcium and low-phosphorus daily ration and 25-hydroxy vitamin D3(ii) a Said low calcium and phosphorus ration and said 25-hydroxy vitamin D3The weight ratio of (A) to (B) is 1kg: 45-55 mug, preferably 1kg:50 mug. In the invention, the low-calcium low-phosphorus daily ration and 25-hydroxy vitamin D are selected3The weight ratio of the vitamin D to the vitamin D is 1kg to 50 mu g, so that the growth performance can be improved, particularly under the preferable weight ratio, the technical problems of piglet oxidative stress aggravation and bone quality low under the condition of low calcium and phosphorus can be better solved, and the low calcium and phosphorus daily ration and the 25-hydroxy vitamin D are used3Can improve the piglet machineImmunity and oxidation resistance in vivo and bone quality, thereby obtaining better feed conversion efficiency and improving growth performance.
According to the feed for weaned pigs provided by the embodiment of the invention, in order to further improve the application effect, the 25-hydroxy vitamin D3Mixing with said low calcium and phosphorus ration in the form of an additive in which 25-hydroxyvitamin D is present3The content of (b) is 0.1-0.2% by mass, preferably 0.125%.
According to the invention, the 25-hydroxyvitamin D3The additive is white fine powder, spray-dried, 25-hydroxy vitamin D3Uniformly distributed in the starch and dextrin.
According to the feed for the weaned piglets provided by the embodiment of the invention, the low-calcium and low-phosphorus daily ration is an early-stage daily ration and/or a later-stage daily ration; preferably, the early-stage daily ration contains 0.55-0.57% of calcium, 0.47-0.49% of total phosphorus and 0.26-0.28% of available phosphorus in percentage by weight; and/or the later-period daily ration contains 0.45-0.47% of calcium, 0.41-0.43% of total phosphorus and 0.20-0.22% of available phosphorus.
According to the feed for the weaned piglets provided by the embodiment of the invention, the early-stage daily ration contains 0.56% of calcium, 0.48% of total phosphorus and 0.27% of available phosphorus in percentage by weight; and/or the later-period daily ration contains 0.46 percent of calcium, 0.42 percent of total phosphorus and 0.21 percent of available phosphorus.
According to the present invention, to more advantageously develop 25-hydroxyvitamin D3The application effect of the invention is that the formula of the low-calcium and low-phosphorus daily ration in different stages is screened, and the following more preferable scheme is obtained: the early-stage daily ration comprises 57.11% of corn, 16.00% of soybean meal, 14.00% of expanded full-fat soybean, 4.00% of fish meal, 4.00% of whey powder, 1.81% of corn starch, 0.72% of soybean oil, 0.26% of calcium hydrophosphate, 0.58% of stone powder, 0.30% of salt, 0.45% of L-lysine hydrochloride, 0.09% of DL-methionine, 0.15% of L-threonine, 0.03% of L-tryptophan and 0.50% of premix according to weight percentage; the late stage daily ration comprises 63.78% of semen Maydis, 18.00%Soybean meal, 10.00 percent of puffed full-fat soybean, 2.00 percent of fish meal, 2.00 percent of whey powder, 1.77 percent of corn starch, 0.11 percent of soybean oil, 0.16 percent of calcium hydrophosphate, 0.65 percent of stone powder, 0.30 percent of salt, 0.45 percent of L-lysine hydrochloride, 0.10 percent of DL-methionine, 0.15 percent of L-threonine, 0.03 percent of L-tryptophan and 0.50 percent of premix.
The embodiment of the invention also provides a method for improving the growth performance, the body immunity level, the body oxidation resistance and the bone quality of piglets, which comprises the following steps: after the piglets are weaned, feeding the piglet feed.
The invention has the beneficial effects that: the invention relates to a para-25-hydroxy vitamin D3The application method of the piglet growth promoter is optimized to improve the growth performance, the immune level, the antioxidant capacity and the bone quality of piglets. Use of 25-hydroxy vitamin D in low calcium and phosphorus ration3Obviously improve the average daily gain of the weaned pigs in the later growth period and the whole growth period, and increase the serum immunoglobulin content, the catalase activity, the bone-specific alkaline phosphatase and the osteocalcin content of the piglets.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described clearly and completely below, and it is obvious that the described embodiments are some, not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The instruments and the like are conventional products which are purchased by normal distributors and are not indicated by manufacturers. The process is conventional unless otherwise specified, and the starting materials are commercially available from the open literature. The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications.
Example 1
The embodiment provides a feed additive for weaned piglets and a using method and application thereof. The additive is 25-hydroxy vitamin D3White homogeneous powder. The low-calcium low-phosphorus daily feed and 25-hydroxy vitamin D3The weight ratio of the 25-hydroxy vitamin D is 1kg to 50 mu g3Mixing with said low calcium and phosphorus ration in the form of an additive in which 25-hydroxyvitamin D is present3The mass percentage of the starch is 0.125 percent, and the rest is starch and dextrin. The additive is 25-hydroxy vitamin D3Continuously adding the feed from the early growth stage (6-9 kg) and the later growth stage (9-14 kg) of the weaned piglets. Compared with low-calcium and low-phosphorus daily ration, 25-hydroxy vitamin D is added3The average daily gain of the weaned piglets in the later growth period and the whole growth period is obviously improved, the serum complement 3 content of the piglets on the 14 th day is reduced, and simultaneously, the serum immunoglobulin IgG, IgA and IgM contents and the catalase activity of the piglets on the 28 th day are improved. In addition, compared with low calcium and phosphorus daily ration, the daily ration is added with 25-hydroxy vitamin D3Obviously improves the serum calcium and bone-specific alkaline phosphatase content of the piglets at the 14 th day and the serum calcium, bone-specific alkaline phosphatase and osteocalcin content at the 28 th day. In conclusion, the low-calcium and low-phosphorus daily ration is added with 25-hydroxy vitamin D3Can improve the growth performance, serum immunity level, oxidation resistance and bone quality of weaned pigs.
The specific method comprises the following steps:
144 healthy three-hybrid (Du X long X big) weaned piglets are selected, the initial weight is 6.33 +/-0.79 kg, the treatment is divided into 3 treatments according to the complete random block test design of the weight and the sex, each treatment comprises 6 repetitions (circles), each repetition comprises 8 pigs, and each half of the male and female pigs. The three treatment groups were: 1) positive Control (PC): normal calcium and phosphorus ration; 2) negative Control (NC): low calcium and phosphorus daily ration; 3) adding 25-hydroxy vitamin D50 mug/kg into low-calcium low-phosphorus daily ration3(NC + 25-D). The 25-D group diets were different from the NC group in that they contained 25-hydroxyvitamin D3。
The PC group is a corn bean pulp type basic ration with normal calcium and phosphorus level, and the early-stage ration comprises 0.80% of calcium, 0.61% of total phosphorus and 0.40% of available phosphorus; the late ration comprises 0.70% calcium, 0.54% total phosphorus and 0.33% available phosphorus. The NC group is a corn bean pulp type basic ration with low calcium and phosphorus levels, and the early-stage ration comprises 0.56% of calcium, 0.48% of total phosphorus and 0.27% of available phosphorus; the late ration comprises 0.46% calcium, 0.42% total phosphorus and 0.21% available phosphorus.
The above test diets were formulated with reference to NRC (2012). The PC group early-stage daily ration formula is as follows: 57.11% of corn, 16.00% of soybean meal, 14.00% of puffed full-fat soybean, 4.00% of fish meal, 4.00% of whey powder, 1.55% of soybean oil, 1.00% of calcium hydrophosphate, 0.82% of stone powder, 0.30% of salt, 0.45% of L-lysine hydrochloride, 0.09% of DL-methionine, 0.15% of L-threonine, 0.03% of L-tryptophan and 0.50% of premix according to weight percentage; the later-period daily ration formula is as follows: 63.78% of corn, 18.00% of soybean meal, 10.00% of puffed full-fat soybean, 2.00% of fish meal, 2.00% of whey powder, 0.92% of soybean oil, 0.87% of calcium hydrophosphate, 0.90% of stone powder, 0.30% of salt, 0.45% of L-lysine hydrochloride, 0.10% of DL-methionine, 0.15% of L-threonine, 0.03% of L-tryptophan and 0.50% of premix. The early-stage daily ration formula of the NC group is as follows: 57.11% of corn, 16.00% of soybean meal, 14.00% of puffed full-fat soybean, 4.00% of fish meal, 4.00% of whey powder, 1.81% of corn starch, 0.72% of soybean oil, 0.26% of calcium hydrophosphate, 0.58% of stone powder, 0.30% of salt, 0.45% of L-lysine hydrochloride, 0.09% of DL-methionine, 0.15% of L-threonine, 0.03% of L-tryptophan and 0.50% of premix; the later-period daily ration formula is as follows: 63.78% of corn, 18.00% of soybean meal, 10.00% of puffed full-fat soybean, 2.00% of fish meal, 2.00% of whey powder, 1.77% of corn starch, 0.11% of soybean oil, 0.16% of calcium hydrophosphate, 0.65% of stone powder, 0.30% of salt, 0.45% of L-lysine hydrochloride, 0.10% of DL-methionine, 0.15% of L-threonine, 0.03% of L-tryptophan and 0.50% of premix.
The piglet premix comprises the following specific formula: each kg of premix contains: vitamin a, 12000 IU; vitamin D3，2500IU；Vitamin E, 30 IU; vitamin K33 mg; vitamin B1212 μ g; riboflavin, 4 mg; 15mg of D-pantothenic acid; nicotinic acid, 30 mg; choline chloride, 400 mg; folic acid, 0.7 mg; vitamin B11.5 mg; vitamin B63 mg; iron, 75 mg; copper, 100 mg; manganese, 40 mg; zinc, 75 mg; iodine, 0.3 mg; selenium, 0.3 mg.
The whole test period is 28d, and the test period is divided into two stages: early stage (d 0 to 14) and late stage (d15 to 28). The powder is used for feeding, and the food is taken and drunk freely.
The results are as follows:
1. 25-hydroxy vitamin D3Influence on growth Performance of weaned piglets
Adding 25-hydroxy vitamin D into daily ration3The effect on growth performance of weaned piglets is shown in table 1. The results show that the average daily gain, the average daily feed intake and the feed conversion rate of the piglets in the PC group and the NC +25-D group have no significant difference. Compared with NC group, the daily ration is added with 25-hydroxy vitamin D3The weight of the piglets at the 28 th day and the average daily gain of the piglets in the later growth period and the whole growth period are obviously improved (P is less than 0.05), and the weight is not obviously different from that of the PC group. In addition, compared with NC group, the daily ration is added with 25-hydroxy vitamin D3Tends to improve the feed conversion ratio in the late growth phase (P0.05) and the full growth phase (P0.06).
TABLE 1 daily ration with 25-hydroxy vitamin D3Influence on growth Performance of weaned piglets
Note: PC: normal calcium phosphorus group; NC: low calcium phosphorus group; NC + 25-D: the low calcium and phosphorus group contains 25-hydroxy vitamin D3P < 0.05 indicates significant differences between treatments, as shown in the table below.
2. 25-hydroxy vitamin D3Influence on serum immune function of weaned piglets
Adding 25-hydroxy vitamin D into daily ration3The effect on serum immune function of weaned piglets is shown in table 2. The results show that the daily ration is added with 25-hydroxy vitamin D3Increase of piglets on day 14 and day IIISerum 25-hydroxy vitamin D for 28 days3And (4) content. Compared with PC group and NC group, the daily ration is added with 25-hydroxy vitamin D3The serum complement 3 content of piglets at day 14 is obviously reduced (P < 0.05), but the serum immunoglobulin and inflammatory factors are not obviously influenced. Compared with NC group, the daily ration is added with 25-hydroxy vitamin D3Obviously improves the serum immunoglobulin IgG, IgA and IgM contents (P is less than 0.05) of the piglets at the 28 th day, but has no obvious influence on the serum inflammatory factors.
TABLE 2 daily ration with 25-hydroxyvitamin D3Influence on serum immune function of weaned piglets
3. 25-hydroxy vitamin D3Influence on the antioxidant capacity of the serum of weaned pigs
Adding 25-hydroxy vitamin D into daily ration3The effect on the antioxidant capacity of the serum of weaned piglets is shown in table 3. The result shows that the oxidation resistance of the piglet serum of the PC group is equivalent to that of the piglet serum of the NC +25-D group. Compared with NC group, the daily ration is added with 25-hydroxy vitamin D3Obviously improves (P is less than 0.05) piglet serum catalase activity at day 28.
TABLE 3 daily ration with 25-hydroxy vitamin D3Influence on the antioxidant capacity of the serum of weaned pigs
4. 25-hydroxy vitamin D3Influence on biochemical indexes of serum bone of weaned pig
Adding 25-hydroxy vitamin D into daily ration3The effect on biochemical indicators of serum bone of weaned piglets is shown in table 4. The results show that compared with NC group, the daily ration is added with 25-hydroxy vitamin D3Remarkably improves (P is less than 0.05)) Serum calcium levels of piglets at day 14, but had no significant effect on bone-specific alkaline phosphatase levels. Compared with NC group, the daily ration is added with 25-hydroxy vitamin D3Remarkably improves (P is less than 0.05) the 28 th-day serum calcium, bone-specific alkaline phosphatase and osteocalcin levels of the piglets, and simultaneously tends to improve the 28 th-day serum phosphorus level of the piglets, but has no remarkable difference compared with the PC group.
TABLE 4 daily ration with 25-hydroxy vitamin D3Influence on biochemical indexes of serum bone of weaned pig
Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. 25-hydroxy vitamin D3Use in improving piglet quality, characterized in that the use is in at least one of the following aspects:
1) the growth performance of the piglets is improved;
2) improving the body immunity level of the piglets
3) Improving the oxidation resistance of the piglet organism;
4) the piglet bone quality is improved;
5) preparing a piglet feed;
the 25-hydroxy vitamin D3The application object of (2) is weaned piglets.
2. 25-hydroxy vitamin D according to claim 13Use of 25-hydroxyvitamin D for improving piglet quality3The feed for the weaned piglets is added with 45-55 mug of feed in a proportion of 1 kg.
3. 25-hydroxy vitamin D according to claim 23Use of 25-hydroxyvitamin D for improving piglet quality3Adding the feed additive in the early growth stage and/or the late growth stage of the weaned piglets; preferably, the feed is continuously added in the early growth stage and the later growth stage of the weaned pigs, wherein the weight of the weaned pigs in the early growth stage is 6-9 kg, and the weight of the weaned pigs in the later growth stage is 9-14 kg.
4. 25-hydroxy vitamin D according to claim 13Use of 25-hydroxyvitamin D for improving piglet quality3The application of the compound feed additive in improving the growth performance, the organism immunity level, the organism oxidation resistance and the bone quality of weaned pigs.
5. 25-hydroxy vitamin D according to any one of claims 1 to 43Use in improving piglet quality, wherein the growth performance comprises improving average daily gain at later and/or full stages of growth; the body immunity level and body antioxidant capacity include increasing serum immunoglobulin content and/or catalase activity; the bone quality comprises increasing serum calcium, bone specific alkaline phosphatase and/or osteocalcin content.
6. A feed for weaned piglets, characterized by containing a low-calcium phosphorus ration and 25-hydroxyvitamin D3(ii) a Said low calcium and phosphorus ration and said 25-hydroxy vitamin D3The weight ratio of (A) to (B) is 1kg: 45-55 mug, preferably 1kg:50 mug.
7. The piglet feed of claim 6, wherein the 25-hydroxyvitamin D is3Mixing with said low calcium and phosphorus ration in the form of an additive in which 25-hydroxyvitamin D is present3The content of (b) is 0.1-0.2% by mass, preferably 0.125%.
8. The piglet feed according to claim 6 or 7, wherein the low calcium and phosphorus ration is an early stage ration and/or a late stage ration; preferably, the early-stage daily ration contains 0.55-0.57% of calcium, 0.47-0.49% of total phosphorus and 0.26-0.28% of available phosphorus in percentage by weight; and/or the later-period daily ration contains 0.45-0.47% of calcium, 0.41-0.43% of total phosphorus and 0.20-0.22% of available phosphorus.
9. The piglet feed according to claim 8, wherein the early ration comprises, in weight percent, 0.56% calcium, 0.48% total phosphorus and 0.27% available phosphorus; and/or the later-period daily ration contains 0.46 percent of calcium, 0.42 percent of total phosphorus and 0.21 percent of available phosphorus.
10. A method for improving the growth performance, the body immunity level, the body oxidation resistance and the bone quality of piglets is characterized by comprising the following steps: feeding the piglet feed of any one of claims 6-9 after weaning the piglet.
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