CN112924137A - In-vitro simulation experiment device and method for portal vein internal pressure detection - Google Patents
In-vitro simulation experiment device and method for portal vein internal pressure detection Download PDFInfo
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- 210000003240 portal vein Anatomy 0.000 title claims abstract description 122
- 238000004088 simulation Methods 0.000 title claims abstract description 30
- 238000000338 in vitro Methods 0.000 title claims abstract description 26
- 238000000034 method Methods 0.000 title claims abstract description 14
- 238000001514 detection method Methods 0.000 title claims description 27
- 238000002474 experimental method Methods 0.000 claims abstract description 42
- 229920001296 polysiloxane Polymers 0.000 claims abstract description 33
- 230000017531 blood circulation Effects 0.000 claims abstract description 25
- 230000002572 peristaltic effect Effects 0.000 claims abstract description 19
- 239000002473 artificial blood Substances 0.000 claims abstract description 9
- 238000005259 measurement Methods 0.000 claims abstract description 7
- 239000011521 glass Substances 0.000 claims description 18
- 239000008280 blood Substances 0.000 claims description 16
- 210000004369 blood Anatomy 0.000 claims description 16
- 241001465754 Metazoa Species 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- 238000005056 compaction Methods 0.000 claims description 5
- 239000012153 distilled water Substances 0.000 claims description 3
- 238000004519 manufacturing process Methods 0.000 claims description 3
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 238000013178 mathematical model Methods 0.000 abstract description 6
- 238000003745 diagnosis Methods 0.000 abstract description 2
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- 230000002440 hepatic effect Effects 0.000 description 2
- 206010019695 Hepatic neoplasm Diseases 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009530 blood pressure measurement Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
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- 238000010276 construction Methods 0.000 description 1
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- G—PHYSICS
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- G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
- G01M10/00—Hydrodynamic testing; Arrangements in or on ship-testing tanks or water tunnels
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01D—MEASURING NOT SPECIALLY ADAPTED FOR A SPECIFIC VARIABLE; ARRANGEMENTS FOR MEASURING TWO OR MORE VARIABLES NOT COVERED IN A SINGLE OTHER SUBCLASS; TARIFF METERING APPARATUS; MEASURING OR TESTING NOT OTHERWISE PROVIDED FOR
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- G01D21/02—Measuring two or more variables by means not covered by a single other subclass
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract
本发明属于无创性诊断技术领域，具体涉及一种门静脉内压检测的体外模拟实验装置及实验方法，实验装置包括实验用门静脉，实验用门静脉的两端分别连接硅胶管Ⅰ段和硅胶管Ⅱ段，硅胶管Ⅰ段和硅胶管Ⅱ段分别连接第一量杯和第二量杯，硅胶管Ⅰ段上设有蠕动泵，用于将第一量杯中的人造血液经由实验用门静脉送至第二量杯中，实验用门静脉和第二量杯处分别设置第一测量组件和第二测量组件，实验方法采用上述实验装置通过血流情况正常实验和人为制造门静脉内压实验能够测得基于流体力学建立数学模型所需的关键影响因子以及门静脉的内压。本发明开创了一种全新的模拟实验方法和思路，具有无创伤、无接触、效果好、成本低、易于实现，可大规模推广等优点。
The invention belongs to the technical field of non-invasive diagnosis, and in particular relates to an in vitro simulated experimental device and an experimental method for detecting the internal pressure of the portal vein. , the first section of the silicone tube and the second section of the silicone tube are connected to the first measuring cup and the second measuring cup, respectively. The first section of the silicone tube is provided with a peristaltic pump, which is used to send the artificial blood in the first measuring cup to the second measuring cup through the experimental portal vein. The experimental portal vein and the second measuring cup are respectively provided with a first measurement component and a second measurement component. The experimental method adopts the above-mentioned experimental device. Through the normal blood flow experiment and the artificially manufactured portal vein internal pressure experiment, the results obtained by establishing a mathematical model based on fluid mechanics can be measured. key influencing factors and the internal pressure of the portal vein. The invention creates a brand-new simulation experiment method and idea, and has the advantages of non-invasiveness, non-contact, good effect, low cost, easy realization, and large-scale promotion.
Description
Technical Field
The invention belongs to the technical field of noninvasive diagnosis, and particularly relates to an in-vitro simulation experiment device and an in-vitro simulation experiment method for portal vein internal pressure detection.
Background
Before the liver tumor operation, the internal pressure detection of the hepatic portal vein is usually needed, and the operation under the condition of excessively high internal pressure causes the problem that the blood volume of a patient is excessively large during the operation, so that the surgical operation is not recommended when the internal pressure of the hepatic portal vein is excessively high.
The existing portal vein internal pressure detection means comprise two categories, namely invasive and non-invasive, the invasive detection technology can cause certain damage to the body health of a patient, and meanwhile, the portal vein internal pressure detection has certain difficulty for surgeons; the conventional noninvasive portal vein internal pressure detection technology mostly adopts the technology of imaging, and the difference rate is large; therefore, it is important to develop a noninvasive detection technique for portal vein pressure.
Disclosure of Invention
The invention aims to solve the problem that invasive and noninvasive portal vein internal pressure detection means in the prior art have certain defects, and provides an in-vitro simulation experiment device and an in-vitro simulation experiment method for portal vein internal pressure detection.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: the utility model provides an external simulation experiment device that portal vein internal pressure detected, includes the portal vein for the experiment, I section of silicone tube and II sections of silicone tube are connected respectively to the both ends of portal vein for the experiment, first graduated flask and second graduated flask are connected respectively to the one end that portal vein for the experiment was kept away from to I section of silicone tube and II sections of silicone tube, be equipped with the peristaltic pump on the I section of silicone tube for artificial blood in the first graduated flask is delivered to the second graduated flask through portal vein for the experiment, portal vein and second graduated flask department set up first measuring component and second measuring component respectively for the experiment.
Preferably, the first measuring component comprises a glass tube vertically arranged above the portal vein for experiment, a needle tube is connected below the glass tube through a movable hose, the needle tube penetrates into the portal vein for experiment, and the direction of the needle tube is consistent with the direction of blood flow.
Preferably, the glass tube is connected to a fixing support through a clamp, the fixing support is arranged on a first support frame, and two ends of the first support frame are respectively supported below the first section of the silicone tube and the second section of the silicone tube.
Preferably, the second measuring assembly comprises a high-density electronic scale arranged below the second measuring cup and a camera arranged on one side of the second measuring cup, and the camera is mounted on the second support frame through a steering gear.
Preferably, the peristaltic pump is arranged on the cushion table, and an inlet and an outlet of the peristaltic pump are arranged on the same horizontal line with an inlet and an outlet of the portal vein for the experiment.
Preferably, the experimental portal vein is selected from the portal veins of animals.
An experimental method of the in-vitro simulation experimental device for detecting the internal pressure of the portal vein comprises the following steps:
(a) setting up an experimental device at the room temperature of 27 +/-0.5 ℃, and dividing the experimental device into a normal blood flow condition experiment and an artificial portal vein internal compaction experiment;
(b) and blood flow condition normal experiment: respectively reading the volume V of the blood and the mass M of the blood once every 10 seconds by a second measuring cup and a high-density electronic scale for n times, and then calculating the blood density rho and the blood flow Q; when the height of the water column in the glass tube is not changed, measuring the distance between the upper section of the water column and the needle tube, and calculating portal vein pressure P; measuring the inner diameter and the outer diameter of the portal vein before and after the peristaltic pump is started to obtain portal vein section measurement data; regulating the flow velocity and the flow rate of blood by a peristaltic pump for m times in total, thereby measuring m groups of blood flow Q, portal vein internal pressure P, portal vein vertical outer diameter L3 and portal vein horizontal outer diameter L4;
(c) artificial manufacturing of portal vein internal compaction test: and (c) clamping and extruding the outlet of the second section of the silicone tube by using a pipeline, and repeating the experimental process in the step (b) to obtain m ' groups of blood flow Q ', portal vein internal pressure P ', the outer diameter L3 ' in the vertical direction of the portal vein and the outer diameter L4 ' in the horizontal direction of the portal vein.
Preferably, the experimental device set up in the step (a) further comprises the steps of injecting distilled water into the glass tube, pouring artificial blood into the first measuring cup, resetting the high-density electronic scale after the second measuring cup is placed, and adjusting the angle of the camera.
Preferably, the experimental data obtained by the experimental method is suitable for mathematical modeling of in vitro portal vein internal pressure noninvasive detection.
After the technical scheme is adopted, the in-vitro simulation experiment device and the in-vitro simulation experiment method for portal vein internal pressure detection provided by the invention have the following beneficial effects:
the invention can measure key influence factors required by establishing a mathematical model based on hydrodynamics and the internal pressure of the portal vein under the condition of no wound, opens a brand new simulation experiment method and thought, can save public resources of hospitals and accelerate the establishment of a portal vein internal pressure non-invasive detection mathematical model based on hydrodynamics; in addition, the invention adopts in vitro simulation, can be used for simulation experiments before clinic and classroom teaching of medical colleges, and has stronger scientificity and practicability; in conclusion, the invention has the advantages of no wound, no contact, good effect, low cost, easy realization, contribution to scale-up popularization and the like.
Drawings
FIG. 1 is a schematic structural diagram of an in-vitro simulation experiment device for portal vein internal pressure detection according to the present invention;
fig. 2 is an enlarged schematic view of a part of the structure of an in-vitro simulation experiment device for portal vein internal pressure detection.
Wherein: the device comprises a peristaltic pump 1, a cushion table 2, a first section 3-1 of a silicone tube, a second section 3-2 of the silicone tube, a portal vein 4 for experiments, a fixed support 5, a first support frame 6, a clamp 7, a glass tube 8, a high-density electronic scale 9, artificial blood 10, a first measuring cup 11, a second measuring cup 12, a needle tube 13-1, a movable hose 13-2, a camera 14, a steering gear 15 and a second support frame 16.
Detailed Description
The present invention now will be described more fully hereinafter with reference to the accompanying drawings and detailed description, in which it is to be understood that the embodiments described are merely illustrative of some, but not all embodiments of the invention. The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
It is noted that the terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of example embodiments according to the present application. As used herein, the singular forms "a", "an" and "the" are intended to include the plural forms as well, and it should be understood that when the terms "comprises" and/or "comprising" are used in this specification, they specify the presence of stated features, steps, operations, devices, components, and/or combinations thereof, unless the context clearly indicates otherwise.
The relative arrangement of the components and steps, the numerical expressions and numerical values set forth in these embodiments do not limit the scope of the present invention unless specifically stated otherwise. Meanwhile, it should be understood that the sizes of the respective portions shown in the drawings are not drawn in an actual proportional relationship for the convenience of description. Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate. In all examples shown and discussed herein, any particular value should be construed as merely illustrative, and not limiting. Thus, other examples of the exemplary embodiments may have different values. It should be noted that: like reference numbers and letters refer to like items in the following figures, and thus, once an item is defined in one figure, further discussion thereof is not required in subsequent figures.
In the description of the present invention, it is to be understood that the orientation or positional relationship indicated by the orientation words such as "front, rear, upper, lower, left, right", "lateral, vertical, horizontal" and "top, bottom", etc. are usually based on the orientation or positional relationship shown in the drawings, and are only for convenience of description and simplicity of description, and in the case of not making a reverse description, these orientation words do not indicate and imply that the device or element being referred to must have a specific orientation or be constructed and operated in a specific orientation, and therefore, should not be considered as limiting the scope of the present invention; the terms "inner and outer" refer to the inner and outer relative to the profile of the respective component itself.
Spatially relative terms, such as "above … …," "above … …," "above … …," "above," and the like, may be used herein for ease of description to describe one device or feature's spatial relationship to another device or feature as illustrated in the figures. It will be understood that the spatially relative terms are intended to encompass different orientations of the device in use or operation in addition to the orientation depicted in the figures. For example, if a device in the figures is turned over, devices described as "above" or "on" other devices or configurations would then be oriented "below" or "under" the other devices or configurations. Thus, the exemplary term "above … …" can include both an orientation of "above … …" and "below … …". The device may be otherwise variously oriented (rotated 90 degrees or at other orientations) and the spatially relative descriptors used herein interpreted accordingly.
It should be noted that the terms "first", "second", and the like are used to define the components, and are only used for convenience of distinguishing the corresponding components, and the terms have no special meanings unless otherwise stated, and therefore, the scope of the present invention should not be construed as being limited.
As shown in fig. 1-2, the in vitro simulation experiment device for portal vein internal pressure detection provided by the present invention comprises an experimental portal vein 4, specifically, the experimental portal vein 4 is selected from animal portal veins, preferably, a pig portal vein, two ends of the experimental portal vein 4 are respectively connected with a first section of silicone tube 3-1 and a second section of silicone tube 3-2, one end of the first section of silicone tube 3-1 and one end of the second section of silicone tube 3-2, which are far away from the experimental portal vein 4, are respectively connected with a first measuring cup 11 and a second measuring cup 12, a peristaltic pump 1 is arranged on the first section of silicone tube 3-1, and is configured to deliver artificial blood 10 in the first measuring cup 11 to the second measuring cup 12 through the first section of silicone tube 3-1, the experimental portal vein 4 and the second section of silicone tube 3-2 in sequence, and the peristaltic pump 1 is arranged on a cushion 2, the device is used for ensuring that the inlet and the outlet of the peristaltic pump 1 and the inlet and the outlet of the portal vein for experiment 4 are arranged on the same horizontal line, and a first measuring component and a second measuring component are respectively arranged at the portal vein for experiment 4 and the second measuring cup 12.
Further, the first measuring assembly comprises a glass tube 8 vertically arranged above the portal vein 4 for experiments, the lower portion of the glass tube 8 is connected with a needle tube 13-1 through a movable hose 13-2, the needle tube 13-1 penetrates into the portal vein 4 for experiments, the direction of the needle tube 13-1 is consistent with the blood flow direction, specifically, the glass tube 8 is connected to a fixing support 5 through a clamp 7, the fixing support 5 is vertically arranged on a first support frame 6, and two ends of the first support frame 6 are respectively supported below the first section 3-1 of the silicone tube and the second section 3-2 of the silicone tube.
Further, the second measuring assembly comprises a high-density electronic scale 9 arranged below the second measuring cup 12 and a camera 14 arranged on one side of the second measuring cup 12, wherein the camera 14 is mounted on the second support frame 16 through a steering gear 15, and the angle of the camera 14 on the second support frame 16 can be conveniently adjusted.
The invention also provides an experimental method of the in-vitro simulation experimental device for the portal vein internal pressure detection, which comprises the following steps:
and (3) establishing an experimental environment:
preparing all experimental equipment as shown in FIGS. 1-2;
controlling the indoor temperature to be 27 +/-0.5 ℃;
measuring the internal diameter L1 and the external diameter L2 of the portal vein 4 of an animal (pig);
an animal (pig) portal vein 4 is connected with a section I3-1 of the silicone tube and a section II 3-2 of the silicone tube;
placing the second measuring cup 12 on the high-precision electronic scale 9, and resetting the high-precision electronic scale 9;
pouring artificial blood 10 into a first measuring cup 11;
fixing the camera 14 on a steering gear 15, wherein the steering gear 15 is connected with a support frame 16;
the fixing support 5 is placed, and the glass tube 8 is fixed through the clamp 7;
the needle tube 13-1 is connected with the glass tube 8 through the movable hose 13-2, the needle tube 13-1 is obliquely inserted into the portal vein 4 of the animal (pig), and the oblique direction of the needle tube 13-1 is consistent with the blood flow direction;
starting a peristaltic pump (1000ml/min), injecting the artificial blood 10 in the first measuring cup 11 into the portal vein 4 of the animal (pig) and then into the second measuring cup 12, wherein the blood flow direction is from right to left;
distilled water was injected into the glass tube 8.
And finishing the construction of the experimental environment.
The experiment was started:
obtaining the influence factors (blood density, blood flow, portal vein thickness, portal vein outer section diameter and blood viscosity, wherein the blood viscosity is known) for establishing the mathematical model.
First, blood flow condition normal experiment
The camera 14 records the whole course, conveniently checking the read parameters (in particular the blood mass), reading the volume V of the blood (V1, V2, V3... Vn) by the second measuring cup 12 every 10 seconds, and simultaneously reading the mass M (M1, M2, M3.. Mn) by the high-precision electronic scale 9, recording n times in total.
(1) Calculating the blood density: ρ ═ (M1/V1+ M2/V2+ M3/V3+. + Mn/Vn)/n, units g/ml;
(2) calculating blood flow: q ═ (V1/10+ V2/20+ V3/30+. + Vn/n)/n, units ml/s;
(3) internal pressure measurement of the animal (pig) portal vein 4: measuring the height of the water column when the height of the water column in the glass tube 8 is unchanged, namely measuring the vertical distance h from the upper section of the water column to the needle tube 13-1, wherein the internal pressure of the portal vein is 1.3605 × h and the unit is mmhg;
(4) portal vein cross-section measurement: before the peristaltic pump is started, the inner diameter of the portal vein 4 of the animal (pig) is measured vertically as L1-1, the outer diameter is measured vertically as L3-1, the portal vein is measured horizontally as L2-1, the outer diameter is measured vertically as L3-1, the portal vein is measured horizontally as L4-1, namely the vertical thickness of the portal vein is L3-1-L1-1, the horizontal thickness of the portal vein is L4-1-L2-1, and the outer diameter of the portal vein 4 of the animal (pig) is measured after the peristaltic pump is started: the vertical measurement is L3-2, the horizontal measurement is L4-2, unit mm;
the flow rate and flow rate of blood were adjusted by the peristaltic pump m times in total (including the first start), and m sets of the outer diameters of the blood flow rate Q, the portal vein internal pressure P, the portal vein vertical direction L3, and the portal vein horizontal direction L4 were measured.
(II) artificial manufacturing portal vein internal compaction test
And (3) clamping and extruding the outlet of the second section 3-2 of the silicone tube by using a pipeline, and repeating the experimental process of the normal experiment of the blood flow condition to obtain m ' groups of blood flow Q ', portal vein internal pressure P ', the outer diameter L3 ' in the vertical direction of the portal vein and the outer diameter L4 ' in the horizontal direction of the portal vein.
Further, the experimental data obtained by the experimental method is suitable for mathematical modeling of extracorporeal portal vein internal pressure noninvasive detection, the mathematical modeling is based on fluid mechanics, specifically, m groups of blood flow Q, portal vein internal pressure P, portal vein vertical external diameter L3, portal vein horizontal external diameter L4 obtained in the above blood flow condition normal experiment, and m ' groups of blood flow Q ', portal vein internal pressure P ', portal vein vertical external diameter L3 ', portal vein horizontal external diameter L4 ' obtained in artificial portal vein internal compression experiment are all input into a computer, and the following steps are taken:
step 1: establishing a control equation;
step 2: closing by using a flow model;
step 3: performing space-time dispersion analysis;
step 4: applying a boundary constraint;
step 5: solving is carried out;
step 6: extracting global physical quantity distribution;
step 7: and establishing a database.
In conclusion, the invention can measure the key influence factors required by establishing the mathematical model based on the hydrodynamics and the internal pressure of the portal vein under the non-invasive condition, creates a brand-new simulation experiment method and thought, can save public resources of hospitals and accelerate the establishment of the non-invasive detection mathematical model of the internal pressure of the portal vein based on the hydrodynamics; in addition, the invention adopts in vitro simulation, can be used for simulation experiments before clinic and classroom teaching of medical colleges, and has stronger scientificity and practicability.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (9)
1. The utility model provides an external simulation experiment device that portal vein internal pressure detected, its characterized in that, includes portal vein (4) for the experiment, I section (3-1) of silicone tube and II sections (3-2) of silicone tube are connected respectively to the both ends of portal vein (4) for the experiment, first graduated flask (11) and second graduated flask (12) are connected respectively to the one end that portal vein (4) for the experiment was kept away from to I section (3-1) of silicone tube and II sections (3-2) of silicone tube, be equipped with peristaltic pump (1) on I section (3-1) of silicone tube for artificial blood (10) in first graduated flask (11) are sent to in second graduated flask (12) via portal vein (4) for the experiment, portal vein (4) and second graduated flask (12) punishment for the experiment set up first measuring component and second measuring component respectively.
2. An in-vitro simulation experiment device for portal vein internal pressure detection according to claim 1, wherein: the first measuring assembly comprises a glass tube (8) vertically arranged above the experimental portal vein (4), the lower side of the glass tube (8) is connected with a needle tube (13-1) through a movable hose (13-2), the needle tube (13-1) pierces the experimental portal vein (4), and the direction of the needle tube (13-1) is consistent with the direction of blood flow.
3. An in-vitro simulation experiment device for portal vein internal pressure detection according to claim 2, wherein: the glass tube (8) is connected to the fixing support (5) through the clamp (7), the fixing support (5) is arranged on the first support frame (6), and two ends of the first support frame (6) are respectively supported below the first section (3-1) of the silicone tube and the second section (3-2) of the silicone tube.
4. An in-vitro simulation experiment device for portal vein internal pressure detection according to claim 1, wherein: the second measuring assembly comprises a high-density electronic scale (9) arranged below the second measuring cup (12) and a camera (14) arranged on one side of the second measuring cup (12), and the camera (14) is mounted on the second supporting frame (16) through a steering gear (15).
5. An in-vitro simulation experiment device for portal vein internal pressure detection according to claim 1, wherein: the peristaltic pump (1) is arranged on the cushion table (2), and an inlet and an outlet of the peristaltic pump (1) and an inlet and an outlet of the portal vein (4) for experiments are arranged on the same horizontal line.
6. An in-vitro simulation experiment device for portal vein internal pressure detection according to claim 1, wherein: the experimental portal vein (4) is selected from the portal veins of animals.
7. An experimental method of an in vitro simulation experimental device for the detection of the internal pressure of the portal vein according to claim 1, wherein: the method comprises the following steps:
(a) setting up an experimental device at the room temperature of 27 +/-0.5 ℃, and dividing the experimental device into a normal blood flow condition experiment and an artificial portal vein internal compaction experiment;
(b) and blood flow condition normal experiment: respectively reading the volume V of the blood and the mass M of the blood once every 10 seconds by a second measuring cup and a high-density electronic scale for n times, and then calculating the blood density rho and the blood flow Q; when the height of the water column in the glass tube is not changed, measuring the distance between the upper section of the water column and the needle tube, and calculating portal vein pressure P; measuring the inner diameter and the outer diameter of the portal vein before and after the peristaltic pump is started to obtain portal vein section measurement data; regulating the flow velocity and the flow rate of blood by a peristaltic pump for m times in total, thereby measuring m groups of blood flow Q, portal vein internal pressure P, portal vein vertical outer diameter L3 and portal vein horizontal outer diameter L4;
(c) artificial manufacturing of portal vein internal compaction test: and (c) clamping and extruding the outlet of the second section of the silicone tube by using a pipeline, and repeating the experimental process in the step (b) to obtain m ' groups of blood flow Q ', portal vein internal pressure P ', the outer diameter L3 ' in the vertical direction of the portal vein and the outer diameter L4 ' in the horizontal direction of the portal vein.
8. The experimental method of the in-vitro simulation experimental device for detecting the internal pressure of the portal vein according to claim 7, wherein: and (c) setting up the experimental device in the step (a), injecting distilled water into the glass tube, pouring artificial blood into the first measuring cup, resetting the high-density electronic scale after the second measuring cup is placed, and adjusting the angle of the camera.
9. The experimental method of the in-vitro simulation experimental device for detecting the internal pressure of the portal vein according to claim 7, wherein: the experimental data obtained by the experimental method is suitable for mathematical modeling of in-vitro portal vein internal pressure noninvasive detection.
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