CN112891978A - Method for distilling biopharmaceutical solution - Google Patents
Method for distilling biopharmaceutical solution Download PDFInfo
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- CN112891978A CN112891978A CN202110092206.1A CN202110092206A CN112891978A CN 112891978 A CN112891978 A CN 112891978A CN 202110092206 A CN202110092206 A CN 202110092206A CN 112891978 A CN112891978 A CN 112891978A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/14—Fractional distillation or use of a fractionation or rectification column
- B01D3/30—Fractionating columns with movable parts or in which centrifugal movement is caused
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D3/00—Distillation or related exchange processes in which liquids are contacted with gaseous media, e.g. stripping
- B01D3/14—Fractional distillation or use of a fractionation or rectification column
- B01D3/32—Other features of fractionating columns ; Constructional details of fractionating columns not provided for in groups B01D3/16 - B01D3/30
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/0052—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with filtering elements moving during filtering operation
- B01D46/0054—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours with filtering elements moving during filtering operation with translational movement
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D46/00—Filters or filtering processes specially modified for separating dispersed particles from gases or vapours
- B01D46/66—Regeneration of the filtering material or filter elements inside the filter
- B01D46/74—Regeneration of the filtering material or filter elements inside the filter by forces created by movement of the filter element
- B01D46/76—Regeneration of the filtering material or filter elements inside the filter by forces created by movement of the filter element involving vibrations
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)
Abstract
The invention relates to the technical field of bio-pharmaceuticals and discloses a bio-pharmaceutical solution distillation method which comprises a support base, wherein a support rod is fixedly connected to the top end of the support base, an arc-shaped pipe sleeve is fixedly connected to the middle of the support rod, an arc-shaped pipe is movably connected to the middle of the arc-shaped pipe sleeve, bio-pharmaceutical solution is placed inside the arc-shaped pipe, a heating device is placed at the bottom end of the arc-shaped pipe, a stirring block is fixedly connected to one side of the arc-shaped pipe, a hose is movably connected to the opening position of one end of the arc-shaped pipe, one end of the hose is fixedly connected with an air inlet, and a steam pipe is fixedly connected to. The steam pushing inner pipe moves downwards to overcome the self weight of the arc-shaped pipe to enable the arc-shaped pipe to rotate, so that the heating position of the arc-shaped pipe is not fixed by the heating device any more, and the problem of cracking of a distillation flask caused by long-time heating of the same position is solved.
Description
Technical Field
The invention relates to the technical field of biological pharmacy, in particular to a distillation method of a biological pharmacy solution.
Background
Biopharmaceuticals refer to the study of organisms, biological tissues, cells, organs, body fluids, etc., using microbiological, biological, medical, biochemical, etc., results. The product is prepared by comprehensively utilizing the principles and methods of microbiology, chemistry, biochemistry, biotechnology, pharmacy and the like, and is used for prevention, treatment and diagnosis. The biopharmaceutical raw materials are mainly natural biological materials, including microorganisms, human bodies, animals, plants, marine organisms and the like, and in the biopharmaceutical process, the prepared solution is required to be purified, wherein the most common purification means is distillation extraction.
However, the existing distillation device for developing the biopharmaceutical solution still has some problems, and the existing evaporation equipment adopts a fixed distillation flask to evaporate the medicine solution, so that the same position of the distillation flask is heated for a long time, the distillation flask is easy to crack, and the service life of the distillation flask is influenced; and do not have the device to gas filtration in the current bio-pharmaceuticals solution distillation plant for during medicine solution easily takes out many impurity and enters into the condenser when distilling, the inside long-time adhesion impurity that accumulates of condenser can cause condensing efficiency to reduce, seriously influences the normal use of condenser.
Disclosure of Invention
Aiming at the defects of the prior distillation equipment in the background technology in the using process, the invention provides a device for distilling a biopharmaceutical solution and a distillation method thereof, which have the advantages of good condensation effect and long service life and solve the technical problems in the background technology.
The invention provides the following technical scheme: a bio-pharmaceutical solution distillation device comprises a support base, wherein a support rod is fixedly connected to the top end of the support base, an arc-shaped pipe sleeve is fixedly connected to the middle of the support rod, an arc-shaped pipe is movably connected to the middle of the arc-shaped pipe sleeve, a bio-pharmaceutical solution is placed in the arc-shaped pipe, a heating device is placed at the bottom end of the arc-shaped pipe, a stirring block is fixedly connected to one side of the arc-shaped pipe, a hose is movably connected to the opening position of one end of the arc-shaped pipe, an air inlet is fixedly connected to one end of the hose, a steam pipe is fixedly connected to one end of the air inlet, an inner pipe is movably connected to the bottom end of the steam pipe, a filter plate is movably connected to the middle of the steam pipe, a spring is fixedly installed at the bottom end of the filter plate, the middle of the condensation outer pipe is fixedly connected with a condensation inner pipe, one end of the condensation outer pipe is fixedly connected with a cold water inlet, and the other end of the condensation outer pipe is fixedly connected with a cold water outlet.
Preferably, one end of the spring is fixedly connected with the filter disc, and the other end of the spring is fixedly connected with the inner tube.
Preferably, the arced tube is rotatable along an arced tube sleeve.
Preferably, a stop block is arranged at the top end of the filter sheet.
Preferably, the inner tube is movable up and down along the central axis of the steam tube.
Preferably, the shifting block is fixedly connected with the arc-shaped pipe, and the shifting block can be pressed to rotate the arc-shaped pipe when the inner pipe moves downwards.
A method of distilling a biopharmaceutical solution, comprising the steps of:
s1, putting the biopharmaceutical solution into the arc-shaped tube, and starting the heating device;
s2, along with the volatilization of the biopharmaceutical solution, steam enters the steam pipe to jack the inner pipe so that the steam overcomes the gravity of one side of the arc pipe to move downwards;
s3, the inner pipe moving downwards pushes the shifting block to enable the arc-shaped pipe to rotate for an angle along the arc-shaped pipe sleeve;
s4, the spring drives the filter plate to move downwards to enable the filter plate to be far away from the stop block above the filter plate;
s5, as the volatilized steam is reduced, the inner pipe is gradually reset under the influence of the self weight of the arc pipe;
and S6, pushing the filter plate to move upwards when the inner pipe moves upwards, and enabling the filter plate to upwards impact the stop block above the filter plate so that impurities adhered to the filter plate fall into the inner pipe.
The invention has the following beneficial effects:
1. the steam pushing inner pipe moves downwards to overcome the self weight of the arc-shaped pipe to enable the arc-shaped pipe to rotate, so that the heating position of the arc-shaped pipe is not fixed by the heating device any more, and the problem of cracking of a distillation flask caused by long-time heating of the same position is solved.
2. The invention avoids the problem that the condensing efficiency of the condensing tube is reduced because impurities carried in steam enter the condensing tube by additionally arranging the filter sheet, and simultaneously, the filter sheet impacts the stop block to generate vibration by utilizing the up-and-down movement of the inner tube, so that the impurities on the filter sheet fall into the inner tube for collection.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic structural view of the heating state of the present invention;
in the figure: 1. a bracket base; 2. a support rod; 3. an arc tube collar; 4. an arc tube; 5. a biopharmaceutical solution; 6. a heating device; 7. a shifting block; 8. a hose; 9. an air inlet; 10. a steam pipe; 11. an inner tube; 12. a filter disc; 13. a spring; 14. a condenser tube clamp; 15. condensing the outer tube; 16. a condensing inner tube; 17. a cold water inlet; 18. and a cold water outlet.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Referring to fig. 1-2, a device for distilling a bio-pharmaceutical solution comprises a support base 1, a support rod 2 is fixedly connected to the top end of the support base 1, an arc tube sleeve 3 is fixedly connected to the middle of the support rod 2, an arc tube 4 is movably connected to the middle of the arc tube sleeve 3, a bio-pharmaceutical solution 5 is placed inside the arc tube 4, a heating device 6 is placed at the bottom end of the arc tube 4, a toggle block 7 is fixedly connected to one side of the arc tube 4, a hose 8 is movably connected to the opening position of one end of the arc tube 4, an air inlet 9 is fixedly connected to one end of the hose 8, a steam tube 10 is fixedly connected to one end of the air inlet 9, an inner tube 11 is movably connected to the bottom end of the steam tube 10, a filter 12 is movably connected to the middle of the steam tube 10, a stopper is arranged at the top, spring 13's one end and cassette 12 fixed connection, the other end and inner tube 11 fixed connection, at the in-process that inner tube 11 reciprocated, drive cassette 12 and reciprocate, thereby make cassette 12 strike the dog of its top at the in-process that shifts up, make the impurity of adhesion on cassette 12 shake and fall to inner tube 11 in, can improve the filter effect of cassette 12, avoid volatilizing in the solution impurity entering condensation inner tube 16 and the adhesion on the inner tube, influence subsequent condensation effect.
The top fixedly connected with condensation pipe clamp 14 of cradling piece 2, the centre swing joint of condensation pipe clamp 14 has condensation outer tube 15, the centre fixedly connected with condensation inner tube 16 of condensation outer tube 15, the one end fixedly connected with cold water entry 17 of condensation outer tube 15, the other end fixedly connected with cold water export 18 of condensation outer tube 15.
The arc pipe 4 can be followed the arc pipe sleeve pipe 3 and rotated, the central axis that the steam pipe 10 can be followed to inner tube 11 reciprocates, make the interior steam of volatilizing of arc pipe 4 can promote inner tube 11 downstream, make inner tube 11 top move and dial piece 7, dial piece 7 and arc pipe 4 fixed connection, and when inner tube 11 downstream, can press and dial piece 7 and make the arc pipe 4 clockwise turning certain angle, thereby change the heating position of 6 pairs of arc pipes 4 of heating device, avoid heating device 6 to heat the same position of arc pipe 4 for a long time, avoid the arc pipe 4 to take place to explode and split.
A method of distilling a biopharmaceutical solution, comprising the steps of:
s1, putting the biopharmaceutical solution 5 into the arc-shaped pipe 4, and starting the heating device 6;
s2, along with the volatilization of the biopharmaceutical solution 5, steam enters the steam pipe 10 to jack the inner pipe 11 to move downwards by overcoming the gravity of one side of the arc-shaped pipe 4;
s3, the inner tube 11 moving downwards pushes the shifting block 7 to enable the arc tube 4 to rotate for an angle along the arc tube sleeve 3;
s4, the spring 13 drives the filter plate 12 to move downwards to make the filter plate 12 far away from the stop block above the filter plate;
s5, as the volatilized steam is reduced, the inner pipe 11 is gradually returned under the influence of the dead weight of the arc pipe 4;
s6, when the inner tube 11 moves upward, the filter sheet 12 is pushed upward, and the filter sheet 12 hits the stopper above the filter sheet to drop the foreign matters adhered to the filter sheet 12 into the inner tube 11.
It is noted that, herein, relational terms such as first and second, and the like may be used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (6)
1. The method for distilling the biopharmaceutical solution comprises a bracket base (1), wherein a bracket rod (2) is fixedly connected to the top end of the bracket base (1), and is characterized in that: an arc-shaped pipe sleeve (3) is fixedly connected in the middle of the support rod (2), an arc-shaped pipe (4) is movably connected in the middle of the arc-shaped pipe sleeve (3), a biopharmaceutical solution (5) is placed in the arc-shaped pipe (4), a heating device (6) is placed at the bottom end of the arc-shaped pipe (4), a stirring block (7) is fixedly connected to one side of the arc-shaped pipe (4), a hose (8) is movably connected to the opening position of one end of the arc-shaped pipe (4), an air inlet (9) is fixedly connected to one end of the hose (8), a steam pipe (10) is fixedly connected to one end of the air inlet (9), an inner pipe (11) is movably connected to the bottom end of the steam pipe (10), a filter sheet (12) is movably connected in the middle of the steam pipe (10), and a spring (13, a condensing pipe clamp (14) is fixedly connected to the top end of the support rod (2), a condensing outer pipe (15) is movably connected to the middle of the condensing pipe clamp (14), a condensing inner pipe (16) is fixedly connected to the middle of the condensing outer pipe (15), a cold water inlet (17) is fixedly connected to one end of the condensing outer pipe (15), and a cold water outlet (18) is fixedly connected to the other end of the condensing outer pipe (15);
the method comprises the following operation steps:
s1, putting the biopharmaceutical solution (5) into the arc-shaped pipe (4), and starting the heating device (6);
s2, along with the volatilization of the biopharmaceutical solution (5), steam enters the steam pipe (10) to jack the inner pipe (11) to move downwards by overcoming the gravity of one side of the arc-shaped pipe (4);
s3, the inner tube (11) moving downwards pushes the shifting block (7) to enable the arc-shaped tube (4) to rotate for an angle along the arc-shaped tube sleeve (3);
s4, the spring (13) drives the filter (12) to move downwards to enable the filter (12) to be far away from the stop block above the filter;
s5, along with the continuous decrease of the volatilized steam, the inner pipe (11) is gradually reset under the influence of the self weight of the arc-shaped pipe (4);
s6, when the inner tube (11) moves upwards, the filter sheet (12) is pushed to move upwards, so that the filter sheet (12) upwards hits a stop above the filter sheet to enable impurities adhered to the filter sheet (12) to fall into the inner tube (11).
2. The method of claim 1 wherein said distilling comprises: one end of the spring (13) is fixedly connected with the filter disc (12), and the other end of the spring is fixedly connected with the inner tube (11).
3. The method of claim 1 wherein said distilling comprises: the arc-shaped pipe (4) can rotate along the arc-shaped pipe sleeve (3).
4. The method of claim 1 wherein said distilling comprises: the top end of the filter disc (12) is provided with a stop block.
5. The method of claim 1 wherein said distilling comprises: the inner pipe (11) is movable up and down along the central axis of the steam pipe (10).
6. The method of claim 1 wherein said distilling comprises: the poking block (7) is fixedly connected with the arc-shaped pipe (4), and the poking block (7) can be pressed to rotate the arc-shaped pipe (4) when the inner pipe (11) moves downwards.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110092206.1A CN112891978A (en) | 2021-01-23 | 2021-01-23 | Method for distilling biopharmaceutical solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110092206.1A CN112891978A (en) | 2021-01-23 | 2021-01-23 | Method for distilling biopharmaceutical solution |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN112891978A true CN112891978A (en) | 2021-06-04 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110092206.1A Pending CN112891978A (en) | 2021-01-23 | 2021-01-23 | Method for distilling biopharmaceutical solution |
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| Country | Link |
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| CN (1) | CN112891978A (en) |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB740903A (en) * | 1951-12-11 | 1955-11-23 | Celanese Corp | Improvements in and relating to steam stills |
| DE102008051364A1 (en) * | 2008-10-15 | 2010-04-22 | Ika-Werke Gmbh & Co. Kg | rotary evaporator |
| US20150209687A1 (en) * | 2014-01-29 | 2015-07-30 | National Pingtung University Of Science & Technology | Microfluidic Chip for Steam Distillation |
| CN208359875U (en) * | 2018-07-06 | 2019-01-11 | 河源达森汽车散热器有限公司 | A kind of lightweight high-performing car condenser |
| CN208493294U (en) * | 2018-06-08 | 2019-02-15 | 乐山凯亚达光电科技有限公司 | A kind of germanium disulfide synthesis distilation device |
| CN209081420U (en) * | 2018-10-24 | 2019-07-09 | 郑州栾信科技有限公司 | A kind of ethanol hydrogen production device based on boron hydride |
| CN111075986A (en) * | 2020-01-13 | 2020-04-28 | 秦宪斌 | Pneumatic actuator for driving regulating valve |
| CN211245566U (en) * | 2019-12-02 | 2020-08-14 | 红河学院 | A pressure self-locking organic chemical distillation reflux device |
| CN211963133U (en) * | 2020-01-06 | 2020-11-20 | 长江大学 | A chemical experiment distillation device |
-
2021
- 2021-01-23 CN CN202110092206.1A patent/CN112891978A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB740903A (en) * | 1951-12-11 | 1955-11-23 | Celanese Corp | Improvements in and relating to steam stills |
| DE102008051364A1 (en) * | 2008-10-15 | 2010-04-22 | Ika-Werke Gmbh & Co. Kg | rotary evaporator |
| US20150209687A1 (en) * | 2014-01-29 | 2015-07-30 | National Pingtung University Of Science & Technology | Microfluidic Chip for Steam Distillation |
| CN208493294U (en) * | 2018-06-08 | 2019-02-15 | 乐山凯亚达光电科技有限公司 | A kind of germanium disulfide synthesis distilation device |
| CN208359875U (en) * | 2018-07-06 | 2019-01-11 | 河源达森汽车散热器有限公司 | A kind of lightweight high-performing car condenser |
| CN209081420U (en) * | 2018-10-24 | 2019-07-09 | 郑州栾信科技有限公司 | A kind of ethanol hydrogen production device based on boron hydride |
| CN211245566U (en) * | 2019-12-02 | 2020-08-14 | 红河学院 | A pressure self-locking organic chemical distillation reflux device |
| CN211963133U (en) * | 2020-01-06 | 2020-11-20 | 长江大学 | A chemical experiment distillation device |
| CN111075986A (en) * | 2020-01-13 | 2020-04-28 | 秦宪斌 | Pneumatic actuator for driving regulating valve |
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