CN112891372A - Hydrogen peroxide and nano-silver compound hand disinfectant and preparation method thereof - Google Patents
Hydrogen peroxide and nano-silver compound hand disinfectant and preparation method thereof Download PDFInfo
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Abstract
The invention provides a hydrogen peroxide and nano-silver compound hand disinfectant and a preparation method thereof, belonging to the technical field of disinfection and comprising 0-1.5% of hydrogen peroxide, 50-100 mg/L of nano-silver with effective mass concentration, 0.1-2% of stabilizer, 0.1-5% of synergistic additive, 0.05-5% of moisturizing component and 1-10% of plant skin-care sterilizing component by mass. The disinfectant adopts an alcohol-free formula, the hydrogen peroxide and the nano-silver are selected for compounding and are used for sterilizing in a synergistic manner, the system is stable, the hydrogen peroxide is nontoxic and residue-free after being decomposed, and the nano-silver can form an antibacterial protective film for continuous sterilization without stimulation and damage to skin; solves the problems that the hand disinfectant in the market has no stimulation to skin, little damage, refreshing and moisturizing, and continuous and effective antibacterial requirements and is difficult to meet, and has wide application prospect in the technical field of disinfection.
Description
Technical Field
The invention relates to a hydrogen peroxide and nano-silver compound hand disinfectant and a preparation method thereof, belonging to the technical field of disinfection.
Background
The inventor finds that at least the following problems exist in the prior art:
the common sterilization components in the existing hand disinfection products mainly comprise volatile alcohols such as ethanol, isopropanol, n-propanol and the like, hydrogen peroxide compound alcohols, chlorhexidine and plant extract sterilization components, and various hand disinfectants have the defects or limitations; the most common quick-drying alcohol disinfectant can take away moisture on the skin when being volatilized, high-concentration ethanol, normal propyl alcohol or isopropyl alcohol can decompose sebum on hands, and the hand skin of a user can be degreased, dried, rough, even peeled and cracked after being frequently used, so that pain and injury are brought to the user; the quaternary ammonium salt disinfectant is easy to foam because the components belong to cationic surfactants, and has a plurality of limitations when being compounded with other components; the hydrogen peroxide hand disinfectant usually takes hydrogen peroxide with the content of about 1 percent as the sterilization concentration, but the single component of the hydrogen peroxide with the concentration is difficult to meet the requirement of hand disinfection, and the hydrogen peroxide with the concentration needs to be compounded with high-concentration alcohols or other disinfection components to achieve the disinfection effect; at present, hand disinfection products taking silver ions as main disinfection components are sold on the market, but the silver ions lose one or more electrons per se, have strong oxidability, have certain damage to skin cells, lose the antibacterial effect after sterilization, and cannot continuously and effectively resist bacteria. The hand disinfectants in the market have the disadvantages of no stimulation to skin, little damage, refreshing and moisturizing skin and persistent and effective antibacterial.
The reference 1-a hydrogen peroxide-silver ion composite disinfectant is a disinfectant prepared by compounding hydrogen peroxide and silver ions, and gelatin is added to form a gelatin-silver ion complex to improve the stability of the silver ions, but the problem of long-term effective bacteriostasis of the disinfectant cannot be solved.
Patent document 1 application publication No. CN112244040A is a hydrogen peroxide silver ion composite disinfectant.
Disclosure of Invention
Based on the problems, the invention designs the hydrogen peroxide and nano-silver compound hand disinfectant, which uses an alcohol-free formula, selects the hydrogen peroxide and the nano-silver for compounding, and has the advantages of synergistic sterilization of the hydrogen peroxide and the nano-silver, stable system, no toxicity or residue after the hydrogen peroxide is decomposed, and capability of forming an antibacterial protective film for continuous sterilization by the nano-silver without stimulation or damage to skin; solves the problem that the hand disinfectant in the market has no stimulation to skin, little damage, refreshing and moisturizing, and continuous and effective antibacterial requirements and is difficult to meet.
The hydrogen peroxide and nano-silver compound hand disinfectant is prepared from 0-1.5% of hydrogen peroxide, 50-100 mg/L of nano-silver with effective mass concentration, 0.1-2% of stabilizer, 0.1-5% of synergistic additive, 0.05-5% of moisturizing component and 1-10% of plant skin-care and sterilization component in parts by mass.
The stabilizer is a combination of two or more of glutathione, phytic acid, sodium pyrophosphate, sodium hexametaphosphate, hydroxyethylidene diphosphonic acid, tartaric acid and maleic acid; the specific type of the glutathione is oxidized glutathione.
The synergistic auxiliary agent is a combination of 1, 3-butanediol and phenoxyethanol.
The moisturizing component is a combination of two or more of glycerol, propylene glycol, amino acid moisturizer, trehalose, hyaluronic acid, sodium hyaluronate, polyglutamic acid, polyquaternary ammonium salt 10 and polyquaternary ammonium salt 51.
The plant skin-care bactericidal component is any one of chamomile extract, witch hazel extract, calendula extract and aloe extract.
The preparation method of the disinfectant comprises the following preparation steps:
(1) quantitatively weighing a half mass of deionized water of the required total mass, putting the deionized water into a mixing container, continuously adding the quantitatively weighed stabilizer, and stirring until the stabilizer is completely dissolved;
(2) quantitatively weighing the needed hydrogen peroxide solution, adding the product obtained in the step (1), and uniformly stirring;
(3) quantitatively weighing the required nano silver solution, the moisturizing component and the plant skin-care and sterilization component, adding the product obtained in the step (2), supplementing deionized water to the required mass, and continuously stirring until the solid substances are completely dissolved.
The beneficial effects are that:
the invention designs a hydrogen peroxide and nano-silver compound hand disinfectant and a preparation method thereof, and solves the problem that the existing hand disinfectant has no stimulation to skin, small damage, refreshing and moisturizing skin and has difficult compatibility of continuous and effective antibacterial requirements.
The hydrogen peroxide and the nano-silver are compounded, so that the hydrogen peroxide and the nano-silver are synergistically sterilized, the system is stable, no toxicity and no residue are generated after the hydrogen peroxide is decomposed, the nano-silver can form an antibacterial protective film for continuous sterilization, and no stimulation or damage is caused to the skin.
The stabilizer has the advantages of reducing the decomposition rate of hydrogen peroxide in storage and transportation and prolonging the storage validity period of the disinfectant.
The synergistic auxiliary agent has the beneficial effects of enhancing the disinfection effect of the disinfectant, and does not contain volatile alcohols, so that the disinfectant has no stimulation and damage to the skin.
The moisturizing component and the plant skin-care sterilizing component have the beneficial effects of not drying, moisturizing and relieving the skin after being used.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
Disclosed herein are embodiments of a hydrogen peroxide and nano-silver compound hand sanitizer:
the hydrogen peroxide and nano-silver compound hand disinfectant is prepared from 0-1.5% of hydrogen peroxide, 50-100 mg/L of nano-silver with effective mass concentration, 0.1-2% of stabilizer, 0.1-5% of synergistic additive, 0.05-5% of moisturizing component and 1-10% of plant skin-care and sterilization component in parts by mass.
The stabilizer is a combination of two or more of glutathione, phytic acid, sodium pyrophosphate, sodium hexametaphosphate, hydroxyethylidene diphosphonic acid, tartaric acid and maleic acid; the specific type of the glutathione is oxidized glutathione.
The synergistic auxiliary agent is a combination of 1, 3-butanediol and phenoxyethanol.
The moisturizing component is a combination of two or more of glycerol, propylene glycol, amino acid moisturizer, trehalose, hyaluronic acid, sodium hyaluronate, polyglutamic acid, polyquaternary ammonium salt 10 and polyquaternary ammonium salt 51.
The plant skin-care bactericidal component is any one of chamomile extract, witch hazel extract, calendula extract and aloe extract.
The embodiment of the preparation method of the hydrogen peroxide and nano-silver compound hand disinfectant is also disclosed in the specification:
(1) quantitatively weighing a half mass of deionized water of the required total mass, putting the deionized water into a mixing container, continuously adding the quantitatively weighed stabilizer, and stirring until the stabilizer is completely dissolved;
(2) quantitatively weighing the needed hydrogen peroxide solution, adding the product obtained in the step (1), and uniformly stirring;
(3) quantitatively weighing the required nano silver solution, the moisturizing component and the plant skin-care and sterilization component, adding the product obtained in the step (2), supplementing deionized water to the required mass, and continuously stirring until the solid substances are completely dissolved.
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be verified by some experimental methods as follows:
killing microorganism test
The sterilization performance was tested by a carrier immersion quantitative sterilization test method with reference to "sterilization specification" (2002 edition). At room temperature, the extract is applied to Staphylococcus aureus, Escherichia coli and Candida albicans for 1min, and the value of the killed microorganism is detected. Wherein the average killing logarithm value of staphylococcus aureus is more than or equal to 3.00, the average killing logarithm value of escherichia coli is more than or equal to 3.00, and the average killing logarithm value of candida albicans is more than or equal to 3.00, namely the qualified standard of the disinfection capability of the hand disinfectant is met.
Bacteriostasis test
According to the technical specification for disinfection (2002), bacteriostatic tablets and negative tablets are manufactured, sterile and dried filter paper sheets are taken, 20 mu l of bacteriostatic agent solution with the actual use concentration is dripped into each filter paper sheet, then the filter paper sheets are flatly placed in a clean sterile plate, and the plate is opened and placed in an incubator (37 ℃) to be baked or naturally dried at room temperature. A sterile cotton swab is dipped in test bacterial suspension with the concentration of 5-5 multiplied by 106cfu/ml and evenly smeared on the surface of a nutrient agar culture medium plate for 3 times. For each application 1 time, the plate should be rotated 60 °, and finally the cotton swab is applied around the edge of the plate for one revolution. The plate was covered and dried at room temperature for 5 min. The sample wafer is lightly pressed with sterile forceps to be tightly attached to the surface of the flat plate. The plate is covered, the plate is placed in an incubator at 37 ℃, and the result is observed after the plate is cultured for 16 to 18 hours. The diameter of the zone (including the patch) was measured with a vernier caliper and recorded. If the diameter of the bacteriostatic ring is larger than 7mm, the bacteriostatic ring is judged to have bacteriostatic action.
Stability test
Referring to the technical Specification for Disinfection (2002 edition), the hand disinfectants are respectively put in a closed container and put in a thermostat at 54 ℃ for 14 days. Respectively measuring the content of the sterilization effective components of the disinfectant before and after placement; measuring the reduction rate of the hydrogen peroxide content by using a titration method; if the reduction rate of the hydrogen peroxide content is less than or equal to 15 percent, the requirement of 1 year of storage life is met.
Skin feel test
Each sample was distributed to 50 users of each sex age group, and was administered 2-8 times daily at a single dose of 20-50ml, and after 7 days, the subjects were statistically informed of skin condition including no significant change, slight dry and rough sensation, significant dry and rough sensation, and desquamation or chapping.
Example 1
On the basis of the disclosed embodiment, the preferred disclosed hydrogen peroxide and nano-silver compound hand disinfectant and preparation method embodiment thereof are as follows:
(1) adding 0.4g of phytic acid, 0.03g of oxidized glutathione, 0.5g of sodium pyrophosphate and 0.2g of hydroxyethylidene diphosphonic acid into 50g of deionized water in sequence, and stirring until the phytic acid, the oxidized glutathione, the sodium pyrophosphate and the hydroxyethylidene diphosphonic acid are completely dissolved;
(2) adding 2g of hydrogen peroxide solution with the initial concentration of 50% to the product obtained in the step (1), and uniformly stirring;
(3) quantitatively weighing 5g of nano silver with initial concentration of 2000mg/L, 1.0g of 1, 3-butanediol, 0.05g of phenoxyethanol, 2.0g of glycerol, 0.08g of hyaluronic acid and 2g of chamomile extracting solution, adding the product obtained in the step (2), supplementing deionized water to the required mass, and continuing stirring for 30min until all solid substances are dissolved.
The tests for killing microorganisms, for inhibiting bacteria and for stability were carried out according to the test methods already disclosed.
Example 2
On the basis of the disclosed embodiment, the preferred disclosed hydrogen peroxide and nano-silver compound hand disinfectant and preparation method embodiment thereof are as follows:
(1) sequentially adding 0.7g of phytic acid, 0.05g of oxidized glutathione and 0.5g of sodium hexametaphosphate into 50g of deionized water, and stirring until the phytic acid, the oxidized glutathione and the sodium hexametaphosphate are completely dissolved;
(2) adding 2g of hydrogen peroxide solution with the initial concentration of 50% to the product obtained in the step (1), and uniformly stirring;
(3) quantitatively weighing 4g of nano silver with the initial concentration of 2000mg/L, 1.0g of 1, 3-butanediol, 1.0g of phenoxyethanol, 1g of propylene glycol, 3g of glycerol, 0.02g of polyglutamic acid and 1g of witch hazel extract, adding the product obtained in the step (2), supplementing deionized water to the required mass, continuing stirring for 30min, and waiting until all solid substances are dissolved.
The tests for killing microorganisms, for inhibiting bacteria and for stability were carried out according to the test methods already disclosed.
Example 3
On the basis of the disclosed embodiment, the preferred disclosed hydrogen peroxide and nano-silver compound hand disinfectant and preparation method embodiment thereof are as follows:
(1) adding 0.8g of phytic acid, 0.01g of oxidized glutathione, 0.5g of sodium pyrophosphate and 0.2g of sodium stannate into 50g of deionized water in sequence, and stirring until the phytic acid, the oxidized glutathione, the sodium pyrophosphate and the sodium stannate are completely dissolved;
(2) adding 2g of hydrogen peroxide solution with the initial concentration of 50% to the product obtained in the step (1), and uniformly stirring;
(3) 3g of nano silver with the initial concentration of 2000mg/L, 0.5g of 1, 3-butanediol, 0.5g of phenoxyethanol, 0.5g of amino acid humectant, 0.5g of propylene glycol and 5g of chamomile extract are quantitatively weighed and added into the product obtained in the step (2), deionized water is added to the required mass, and the mixture is continuously stirred for 30min until all solid substances are dissolved.
The tests for killing microorganisms, for inhibiting bacteria and for stability were carried out according to the test methods already disclosed.
Example 4
On the basis of the disclosed embodiment, the preferred disclosed hydrogen peroxide and nano-silver compound hand disinfectant and preparation method embodiment thereof are as follows:
(1) adding 0.5g of phytic acid, 0.03g of oxidized glutathione, 0.2g of sodium pyrophosphate and 0.2g of sodium hexametaphosphate into 50g of deionized water in sequence, and stirring until the phytic acid, the oxidized glutathione, the sodium pyrophosphate and the sodium hexametaphosphate are completely dissolved;
(2) adding 2g of hydrogen peroxide solution with the initial concentration of 50% to the product obtained in the step (1), and uniformly stirring;
(3) quantitatively weighing 4.5g of nano silver with the initial concentration of 2000mg/L, 0.5g of 1, 3-butanediol, 0.2g of phenoxyethanol, 3g of glycerol, 0.05g of hyaluronic acid and 8g of aloe extract, adding the product obtained in the step (2), supplementing deionized water to the required mass, and continuously stirring for 30min until all solid substances are dissolved.
The tests for killing microorganisms, for inhibiting bacteria and for stability were carried out according to the test methods already disclosed.
Example 5
On the basis of the disclosed embodiment, the preferred disclosed hydrogen peroxide and nano-silver compound hand disinfectant and preparation method embodiment thereof are as follows:
(1) adding 0.4g of phytic acid, 0.03g of oxidized glutathione, 0.5g of sodium pyrophosphate and 0.2g of fumaric acid into 50g of deionized water in sequence, and stirring until all components are dissolved;
(2) adding 2g of hydrogen peroxide solution with the initial concentration of 50% to the product obtained in the step (1), and uniformly stirring;
(3) quantitatively weighing 3.5g of nano silver with the initial concentration of 2000mg/L, 0.8g of 1, 3-butanediol, 0.2g of phenoxyethanol, 0.1g of sodium hyaluronate, 0.03g of polyglutamic acid and 5.0g of calendula extract, adding the mixture into the product obtained in the step (2), supplementing deionized water to the required mass, and continuing stirring for 30min until all solid substances are dissolved.
The tests for killing microorganisms, for inhibiting bacteria and for stability were carried out according to the test methods already disclosed.
Comparative example 1
On the basis of example 1, no nano silver substance was added as a comparative example to example 1.
Comparative example 2
In addition to example 1, stabilizer substances such as oxidized glutathione, sodium pyrophosphate, hydroxyethylidene diphosphonic acid and the like were not added as comparative examples of example 1.
Comparative example 3
In addition to example 1, a synergist such as 1, 3-butanediol and 0.05g phenoxyethanol was not added, and the resulting mixture was used as a comparative example of example 1.
Comparative example 4
In addition to example 1, moisture retention component-based substances such as glycerin and hyaluronic acid were not added, and the comparative example of example 1 was prepared.
Comparative example 5
In addition to example 1, a plant skin-care and bactericidal component-type substance such as a chamomile extract was not added, and this was used as a comparative example in example 1.
From examples 1 to 5, it can be seen that within the scope of the features of the claims, the hydrogen peroxide disinfectant has the beneficial effects of high-efficiency sterilization, continuous bacteriostasis, hydrogen peroxide storage and transportation decomposition rate of less than 15%, storage validity period of 1 year, no irritation and damage to skin caused by volatile alcohol, no dryness after use, moisture retention and skin soothing.
As can be seen from example 1 and comparative example 1, the nano-silver substance has a significant effect on the sustained bacteriostasis of the hand disinfectant, and the characteristics described in the claims are reasonably and sufficiently characterized to prove the beneficial effects described herein.
As can be seen from example 1 and comparative example 2, the stabilizer class of substances has a significant effect on inhibiting the decomposition of hydrogen peroxide and improving the shelf life of hand disinfectants, and the features claimed above demonstrate reasonably sufficient characteristics to demonstrate the beneficial effects described herein.
As can be seen from example 1 and comparative example 3, the builder substance has a significant effect on improving the disinfecting ability of the hand sanitizer, and the above proves that the features recited in the claims have reasonably sufficient characteristics to prove the beneficial effects described herein.
As can be seen from example 1 and comparative example 5, the plant skin-care bactericidal component has a remarkable effect of improving the capability of the hand disinfectant in killing escherichia coli and candida albicans, and the beneficial effects described herein are proved by the characteristics reasonably and sufficiently stated in the claims.
Comparative example 6
On the basis of the disclosed examples, a practical trial case of different types of hand disinfectants is disclosed herein to compare whether each product has adverse effects on human skin including hand skin degreasing, dryness, roughness, even peeling and chapping after long-term use. Test sample a was a hand sanitizer prepared by any of the methods of examples 1-5; test sample B is the hand sanitizer made by the method of comparative example 4; the test sample C is a disinfectant which is sold in the market and takes volatile alcohols isopropanol and ethanol as main effective components; the test sample D is a disinfectant which is sold in the market and takes volatile alcohol ethanol, normal propyl alcohol or isopropyl alcohol as a main effective component; the skin feel test was performed on the samples, and the specific results are given in the following table:
| group of | Without significant change or substantial wetting | Slight feeling of dryness or roughness | Apparent dryness or roughness | Peeling or chapping |
| A | 46 | 4 | 0 | 0 |
| B | 15 | 25 | 10 | 0 |
| C | 3 | 16 | 27 | 6 |
| D | 4 | 13 | 25 | 8 |
From the above test results, it can be seen that the preferred method disclosed herein produces a hand sanitizer that has a significant improvement in hand skin degreasing, drying, roughness, and even peeling and chapping over commercially available volatile alcohol hand sanitizers, demonstrating the benefits described herein. Comparing A, B the test results of the samples, it is found that the moisturizing component of the claims has beneficial effects of improving the dryness of the skin surface, not drying after use, moisturizing and soothing the skin.
It will be understood by those of ordinary skill in the art that the foregoing embodiments are specific examples of implementing the invention, and that various changes in form and details may be made therein without departing from the spirit and scope of the invention in its practical application.
Claims (7)
1. A preparation method of a hydrogen peroxide and nano-silver compound hand disinfectant is characterized in that the preparation raw materials comprise, by mass, 0-1.5% of hydrogen peroxide, 50-100 mg/L of nano-silver with effective mass concentration, 0.1-2% of a stabilizer, 0.1-5% of a synergistic additive, 0.05-5% of a moisturizing component and 1-10% of a plant skin-care sterilizing component; the preparation method comprises the following steps:
(1) quantitatively weighing a half mass of deionized water of the required total mass, putting the deionized water into a mixing container, continuously adding the quantitatively weighed stabilizer, and stirring until the stabilizer is completely dissolved;
(2) quantitatively weighing the needed hydrogen peroxide solution, adding the product obtained in the step (1), and uniformly stirring;
(3) quantitatively weighing the required nano silver solution, the moisturizing component and the plant skin-care and sterilization component, adding the product obtained in the step (2), supplementing deionized water to the required mass, and continuously stirring until the solid substances are completely dissolved.
2. The method for preparing a hydrogen peroxide and nano-silver compound hand sanitizer according to claim 1, wherein the stabilizer is a combination of two or more of glutathione, phytic acid, sodium pyrophosphate, sodium hexametaphosphate, hydroxyethylidene diphosphonic acid, tartaric acid and fumaric acid.
3. The method for preparing the hydrogen peroxide and nano-silver compound hand sanitizer according to claim 2, wherein the specific type of glutathione is oxidized glutathione.
4. The method for preparing the hydrogen peroxide and nano-silver compound hand sanitizer according to claim 1, wherein the synergistic additive is a combination of 1, 3-butanediol and phenoxyethanol.
5. The method for preparing a hydrogen peroxide and nano-silver compound hand sanitizer according to claim 1, wherein the moisturizing component is a combination of two or more of glycerin, propylene glycol, an amino acid humectant, trehalose, hyaluronic acid, sodium hyaluronate, polyglutamic acid, polyquaternium 10 and polyquaternium 51.
6. The method for preparing a hydrogen peroxide and nano-silver compound hand sanitizer according to claim 1, wherein the plant skin-care bactericidal component is any one of chamomile extract, witch hazel extract, calendula extract and aloe extract.
7. A hydrogen peroxide and nano silver compound hand sanitizer prepared by the method of any one of claims 1 to 6.
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