CN112816306A

CN112816306A - Automatic shaking mechanism for fluorescence immunoassay analyzer

Info

Publication number: CN112816306A
Application number: CN202011620201.3A
Authority: CN
Inventors: 刘远建; 邱胜; 游坤; 冷原野
Original assignee: Chongqing Keysmile Biotechnology Co ltd
Current assignee: Chongqing Keysmile Biotechnology Co ltd
Priority date: 2020-12-31
Filing date: 2020-12-31
Publication date: 2021-05-18
Anticipated expiration: 2040-12-31
Also published as: CN112816306B

Abstract

The invention discloses an automatic shaking mechanism for a fluorescence immunoassay analyzer, comprising a support frame on which a slider capable of sliding up and down in a vertical direction, and a linear drive module for driving the slider to slide are installed on the support frame , a collet module is rotatably installed on the slide block for holding the sample tube, a gear is fixed on the collet module, and a rack is fixed on the support frame; at least part of the slide block is fixed During the sliding stroke, the gear can engage with the rack to drive the collet module to rotate. The beneficial effects of the invention are: after the sample tube is clamped on the chuck module, the liquid to be detected in the sample tube can be automatically shaken, and the shaking effect is good, and it is especially suitable for automatic fluorescence immunoassay equipment with high integration. .

Description

Automatic shaking mechanism for fluorescence immunoassay analyzer

Technical Field

The invention relates to the technical field of medical inspection and analysis instruments, in particular to an automatic shaking mechanism for a fluorescence immunoassay analyzer.

Background

The fluorescence immunoassay technology is a common technical means in biomedical inspection, and has a series of advantages of high sensitivity, strong specificity, high detection speed, safety, stability and the like. The fluorescence immunoassay technology can be used for measuring low-content bioactive compounds, such as proteins (enzymes, receptors and antibodies), hormones (steroids, thyroid hormones and phthalein hormones), drugs, microorganisms and the like, and is widely applied to the detection fields of infectious disease detection, tumor marker detection, blood and cytology detection and the like at present.

In traditional immunoassay equipment, shake even and utilize drive equipment such as motor to drive the carrier that loads sample and reagent to use its axis to rotate as rotation center generally, because fluorescence immunoassay's shake even process is gone on in longer sample tube, traditional shake even mode effect is not ideal enough, is difficult to satisfy the detection requirement.

Disclosure of Invention

In view of this, the present invention provides an automatic shaking mechanism for a fluorescence immunoassay analyzer, which can automatically shake up a liquid to be detected in a sample tube.

In order to achieve the purpose, the technical scheme of the invention is as follows:

the utility model provides an automatic even mechanism that shakes for fluorescence immunoassay appearance which the key lies in: the sample tube clamping device comprises a support frame, wherein a sliding block capable of sliding up and down along the vertical direction and a linear driving module driving the sliding block to slide are arranged on the support frame; the gear can be meshed with the rack in at least partial sliding stroke of the sliding block to drive the chuck module to rotate.

By adopting the structure, after the sample tube is clamped by the chuck module, the linear driving module drives the sliding block to slide relative to the supporting frame, and due to the meshing action of the gear and the rack, the chuck module can rotate around the central line of the gear in the sliding process of the sliding block so as to drive the sample tube to rotate, so that in the meshing range of the rack, the linear driving module drives the sliding block to do reciprocating motion so as to realize the reciprocating swing of the sample tube, thereby realizing the automatic shaking.

Preferably, the method comprises the following steps: the sliding stroke of the sliding block comprises a shaking area and a non-shaking area, and the mounting position of the rack in the height direction of the support frame is located in the shaking area. By adopting the structure, the gear cannot be meshed with the rack in the non-shaking area at the lower end of the sliding stroke of the sliding block, and the sliding block drives the chuck module to do linear lifting motion, so that the chuck module can grab the sample tube downwards.

Preferably, the method comprises the following steps: the upper end of the support frame is provided with a lateral support plate, and the rack is fixedly arranged on the lateral support plate. Adopt above-mentioned structure to the rack is convenient for install.

Preferably, the method comprises the following steps: and the chuck module and/or the sliding block are/is provided with a reset magnet. By adopting the structure, after the sample tube is shaken uniformly, the reset magnet can keep the clamping head of the chuck module vertical, thereby being beneficial to taking and placing the sample tube.

Preferably, the method comprises the following steps: the linear driving module comprises a motor and a lead screw driven to rotate by the motor, and a motor nut in threaded sleeve connection with the lead screw is arranged on the sliding block. By adopting the structure, the motor can drive the sliding block to slide up and down along the guide rail when working, and meanwhile, the screw rod has a self-locking function, so that the self-locking of the chuck module can be ensured, and the chuck module can not fall off automatically.

Preferably, the method comprises the following steps: the chuck module comprises a supporting seat, two groups of chuck fingers are rotatably mounted on the supporting seat, and an elastic element is connected between the two groups of chuck fingers and used for driving the two groups of chuck fingers to rotate towards the direction of mutual approaching; the chuck is characterized in that a steering engine and a rotating part driven by the steering engine to rotate are installed on the supporting seat, two groups of rollers are eccentrically installed on the rotating part, and the two groups of rollers are located between the two groups of chuck fingers. Adopt above-mentioned structure, when snatching the sample tube, steering wheel drive rotary part rotates for two sets of chuck fingers are propped open by the roller of eccentric settings, then put two sets of chuck fingers in the sample tube upper end, and the steering wheel releases drive power, and two sets of chuck fingers press from both sides tight the sample tube under elastic element's effect, and this clamp force is provided by elastic element, even if after the steering wheel outage, the sample tube still can keep pressing from both sides tight state.

Preferably, the method comprises the following steps: the supporting seat is provided with a rotating shaft, and the two groups of chuck fingers are rotatably arranged on the rotating shaft. The inner side of one end, far away from the rotating shaft, of each chuck finger is provided with a clamping groove, and the rotating part is located between the clamping groove and the rotating shaft. By adopting the structure, the rotating part can make the clamping grooves on the two sides away from each other by rotating, thereby being beneficial to grabbing the sample tube.

Compared with the prior art, the invention has the beneficial effects that:

1. after the sample tube is clamped on the chuck module, the liquid to be detected in the sample tube can be automatically shaken up and down through the composite motion formed by rotation, the shaking up effect is good, and the device is particularly suitable for automatic fluorescence immunoassay equipment with high integration level.

2. After the sample tube is clamped, the clamping force of the sample tube is completely provided by the elastic element on the chuck module, the sample tube clamping device belongs to a flexible clamping mode, the sample tube cannot be damaged, and the sample tube can still be clamped and cannot fall off after the system is powered off.

Drawings

FIG. 1 is a schematic structural diagram of an initial state of an automatic shaking mechanism clamping a sample tube;

FIG. 2 is a schematic structural view of the automatic shaking mechanism clamping the sample tube and rotating a certain angle;

FIG. 3 is a schematic structural diagram of the automatic shaking mechanism clamping the sample tube to rotate to the highest point;

FIG. 4 is a schematic structural view of a chuck module;

FIG. 5 is a front view of the chuck module;

fig. 6 is a schematic diagram showing the rotating component driving two groups of chuck fingers to spread.

Detailed Description

The present invention will be further described with reference to the following examples and the accompanying drawings.

As shown in fig. 1 to 3, an automatic shaking-up mechanism for a fluorescence immunoassay analyzer structurally comprises a support frame 1, a guide rail 1b arranged in the vertical direction is mounted on the support frame 1, a sliding block 2 is mounted on the guide rail 1b in a sliding manner, a linear driving module 3 is arranged on the support frame 1, the linear driving module 3 comprises a motor 3a and a screw rod 3b, a motor nut 3c is sleeved on the screw rod 3b in a threaded manner, the motor nut 3c is fixedly connected with the sliding block 2, and the motor 3a drives the screw rod 3b to rotate so as to drive the sliding block 2 to slide up and down relative to the guide rail 1 b.

Be equipped with chuck module 4 on slider 2, be provided with gear 5 on the chuck module 4, gear 5 rotates and installs on slider 2, there is rack 6 upper end of support frame 1 through side direction backup pad 1a fixed mounting, gliding in-process from top to bottom at slider 2, gear 5 can be with rack 6 meshing again, thereby drive chuck module 4 is rotatory, so chuck module 4 cliies the back with sample cell 8, under the driving action of sharp drive module 3, sample cell 8 can carry out the up-and-down motion, can carry out reciprocating rotary motion again, thereby realize shaking evenly voluntarily.

In this embodiment, in order to facilitate the gripping of the sample tube 8 by the gripper module 4, the sliding stroke of the slider 2 can be divided into two sections, namely, a shaking area and a non-shaking area, the shaking area is located at the upper part of the sliding stroke of the slider 2, the non-shaking area is located at the lower part of the sliding stroke of the slider 2, and the rack 6 is installed in the shaking area, so that the slider 2 can be controlled by a program to work only in the shaking area in the shaking process. Meanwhile, when the slide block 2 works in a non-shaking area, the gear 5 is not meshed with the rack 6, and the slide block 2 drives the chuck module 4 to do linear lifting motion only, so that the chuck module 4 can move to the position of the sample tube 8 in a lifting motion mode, and grabbing work is realized.

Be equipped with reset magnet 7 on the chuck module 4, when slider 2 from shake even regional slip to non-shake even regional preparation downstream and remove to snatch sample cell 8, the chuck that can adjust chuck module 4 through reset magnet 7 adsorption can indicate that 4a is in vertical state to be favorable to accurate snatching sample cell 8.

Further, as shown in fig. 2, 4, 5 and 6, the chuck module 4 includes a support seat 4b and two sets of chuck fingers 4a facing the support seat, a rotating shaft 4f is disposed on the support seat 4b, one ends of the two sets of chuck fingers 4a are rotatably mounted on the rotating shaft 4f, the other ends of the two sets of chuck fingers are provided with a clamping groove 4g, an elastic element 4c is connected between the two sets of chuck fingers 4a, the elastic element 4c is a tension spring in this embodiment, and two ends of the tension spring are respectively connected to the two sets of chuck fingers 4a in a hanging manner. The supporting seat 4b is provided with a steering engine 4d and a rotating part 4e driven by the steering engine 4d to rotate, the rotating part 4e is eccentrically provided with two groups of rollers 41, and the two groups of rollers 41 are positioned between the two groups of chuck fingers 4 a.

The working principle of the chuck module 4 for clamping the sample tube 8 is as follows:

steering wheel 4d drive rotary part 4e rotates, two sets of rollers 41 of eccentric settings on rotary part 4e respectively with the inboard contact of chuck finger 4a to drive two sets of chuck fingers 4a and overcome the resistance of extension spring and rotate towards opposite direction, make the interval between two centre gripping grooves 4g increase, then put two sets of chuck fingers 4a in sample pipe 8 upper end, steering wheel 4d releases its drive power, two centre gripping grooves 4g can inwards press from both sides tight sample pipe 8 under the effect of extension spring.

As shown in fig. 4 and 5, when the sample tube 8 is clamped, in order to limit the rotation of the chuck fingers 4a around the rotation shaft 4f in a plane, a positioning spring 4h is connected between one of the chuck fingers 4a and the support seat 4b, and the positioning spring 4h can play a positioning role.

As shown in fig. 4, the supporting seat 4b is provided with a contact sensor 4i, one of the chuck fingers 4a is provided with a sensing piece 4k, and when the sample tube 8 is grasped, the arrangement of the sensing piece 4k and the contact sensor 4i can judge whether the sample tube 8 is successfully clamped.

Finally, it should be noted that the above-mentioned description is only a preferred embodiment of the present invention, and those skilled in the art can make various similar representations without departing from the spirit and scope of the present invention.

Claims

1. An automatic shaking mechanism for a fluorescence immunoassay analyzer, characterized in that it comprises a support frame (1), on which a slider (2) capable of sliding up and down in a vertical direction is installed on the support frame (1). , and a linear drive module (3) that drives the sliding block (2) to slide, on which a collet module (4) is rotatably mounted for clamping the sample tube, and the collet module ( 4) A gear (5) is fixed thereon, and a rack (6) is fixedly installed on the support frame (1); in at least part of the sliding stroke of the slider (2), the gear (5) can be connected with the rack (6) engage to drive the collet module (4) to rotate.

2. The automatic shaking mechanism for a fluorescence immunoassay analyzer according to claim 1, wherein the sliding stroke of the slider (2) includes a shaking area and a non-shaking area, and the rack (2) 6) The installation position in the height direction of the support frame (1) is located in the shaking area.

3. The automatic shaking mechanism for a fluorescence immunoassay analyzer according to claim 2, characterized in that: the upper end of the support frame (1) is provided with a lateral support plate (1a), and the rack (6) is fixed on the lateral support plate (1a).

4 . The automatic shaking mechanism for a fluorescence immunoassay analyzer according to claim 1 , wherein a reset magnet ( 7 ) is provided on the chuck module ( 4 ) and/or the slider ( 2 ). 5 .

5. The automatic shaking mechanism for a fluorescence immunoassay analyzer according to any one of claims 1 to 4, wherein a guide rail (1b) is installed on the support frame (1), and a slider (2) ) is slidably installed on the guide rail (1b), the linear drive module (3) includes a motor (3a) and a screw (3b) driven and rotated by the motor (3a), and the slider (2) is provided with The motor nut (3c) that is threadedly sleeved with the lead screw (3b).

6. The automatic shaking mechanism for a fluorescence immunoassay analyzer according to any one of claims 1 to 4, wherein the chuck module (4) comprises a support seat (4b), the support seat Two sets of chuck fingers (4a) are rotatably installed on (4b), and elastic elements (4c) are connected between the two sets of chuck fingers (4a) for driving the two sets of chuck fingers (4a) to approach each other The steering gear (4d) and the rotating part (4e) driven and rotated by the steering gear (4d) are installed on the support base (4b), and two sets of rollers are eccentrically installed on the rotating part (4e). (41), the two groups of the rollers (41) are located between the two groups of the chuck fingers (4a).

7. The automatic shaking mechanism for a fluorescence immunoassay analyzer according to claim 6, characterized in that: the support base (4b) is provided with a rotating shaft (4f), and two sets of the chuck fingers (4a) Both are rotatably mounted on the shaft (4f).

8. The automatic shaking mechanism for a fluorescence immunoassay analyzer according to claim 6, characterized in that: a clamping groove (4g) is provided on the inner side of one end of the gripper finger (4a) away from the rotating shaft (4f), The rotating part (4e) is located between the clamping groove (4g) and the rotating shaft (4f).

9. The automatic shaking mechanism for a fluorescence immunoassay analyzer according to claim 6, wherein a positioning spring (4h) is connected between one of the gripper fingers (4a) and the support seat (4b) .