CN112782280B - Linear polarization microwave thermoacoustic imaging method and device - Google Patents
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Abstract
本发明提出了一种定量检测目标介电各向异性的线偏振微波热声测量方法与装置,通过应用四个线性偏振微波作为激发源,在微波吸收之上新提出的参数值在0和1之间,能够根据微波吸收特性,用新提出的参数值0到1量化目标的微观各向异性程度。该方法的可行性通过介电各向异性样品验证,该方法为组织偏振测量提供了一种有效且直接的策略,为生物成像和材料检查预先设定了很大的潜力。并且也为检测目标的微观各向异性的微波热声测量提供了有效的方法。
The invention proposes a linearly polarized microwave thermoacoustic measurement method and device for quantitatively detecting the dielectric anisotropy of a target. By using four linearly polarized microwaves as excitation sources, the newly proposed parameter values above microwave absorption are between 0 and 1. In between, the microscopic anisotropy degree of the target can be quantified with the newly proposed parameter value 0 to 1 according to the microwave absorption characteristics. The feasibility of this method is validated with dielectric anisotropy samples, which provides an efficient and straightforward strategy for tissue polarization measurements, presetting a great potential for bioimaging and material inspection. And it also provides an effective method for microwave thermoacoustic measurement to detect the microscopic anisotropy of the target.
Description
技术领域technical field
本发明属于微波热声成像技术领域,特别涉及线偏振微波热声层析成像装置及其方法。The invention belongs to the technical field of microwave thermoacoustic imaging, and particularly relates to a linear polarization microwave thermoacoustic tomography imaging device and a method thereof.
背景技术Background technique
微波热声成像技术是一种具有广泛应用潜力和良好的应用前景的新型无损检测技术。微波热声成像技术兼有超声成像的高分辨和微波成像的高对比度的优点,该技术对生物组织的介电性质分布进行高分辨和高对比度成像,微波热声成像技术通过非电离辐射脉冲微波辐射到生物组织上,生物组织将会吸收微波能量转化为内能,组织瞬间温升导致形体上的热膨胀,热膨胀过程中将会产生压力波即超声波向组织的四周扩散,产生的超声波会被组织超声换能器探测截获,通过超声信号的采集反演出组织内部微波吸收差异图像。通常使用非偏振脉冲微波作为激发源,假设目标是介电各向同性。然而,据报道,有些生物组织在长轴上显示出明显的介电各向异性。传统的热声成像不足以表现出这种组织的各向异性特性,这限制了其在生物和材料领域的应用。在这项工作中,我们提出了一种偏振微波热声成像系统(PMTA),能够根据其微波吸收特性,用新提出的参数值0到1来量化目标的微观各向异性程度。利用吸收偏振微波的声波,可以为组织偏振测量提供直接的策略。Microwave thermoacoustic imaging technology is a new type of non-destructive testing technology with wide application potential and good application prospects. Microwave thermoacoustic imaging technology combines the advantages of high resolution of ultrasonic imaging and high contrast of microwave imaging. This technology can perform high-resolution and high-contrast imaging of the distribution of dielectric properties of biological tissue. When radiated to biological tissue, the biological tissue will absorb microwave energy and convert it into internal energy. The instantaneous temperature rise of the tissue causes thermal expansion on the body. During the thermal expansion process, a pressure wave will be generated, that is, the ultrasonic wave will diffuse around the tissue, and the generated ultrasonic wave will be absorbed by the tissue. The ultrasonic transducer detects and intercepts, and through the acquisition of ultrasonic signals, an image of the difference in microwave absorption inside the tissue is inverted. Typically unpolarized pulsed microwaves are used as the excitation source, assuming that the target is dielectric isotropy. However, some biological tissues have been reported to display pronounced dielectric anisotropy along the long axis. Conventional thermoacoustic imaging is not sufficient to represent the anisotropic properties of this tissue, which limits its application in biological and materials fields. In this work, we propose a polarized microwave thermoacoustic imaging system (PMTA) capable of quantifying the degree of microscopic anisotropy of a target with newly proposed parameter values from 0 to 1 according to its microwave absorption properties. Using acoustic waves that absorb polarized microwaves provides a straightforward strategy for tissue polarization measurements.
发明内容SUMMARY OF THE INVENTION
本发明的首要目的在于克服现有方法的缺点与不足,提供一种定量检测目标的微观各向异性的PMTA方法,为了解决上述技术问题,本发明的技术方案是:通过应用四个线偏振微波作为激发源,基于矢量微波吸收定量检测目标的微观各向异性。根据其微波吸收特性,用新提出的公式得到的参数值0到1来量化目标的微观各向异性程度,利用吸收偏振微波的声波,可以为组织偏振测量提供直接的策略。The primary purpose of the present invention is to overcome the shortcomings and deficiencies of the existing methods, and to provide a PMTA method for quantitatively detecting the microscopic anisotropy of the target. In order to solve the above-mentioned technical problems, the technical scheme of the present invention is: by applying four linearly polarized microwaves As an excitation source, the microscopic anisotropy of the target is quantitatively detected based on vector microwave absorption. According to its microwave absorption properties, parameter values from 0 to 1 obtained by the newly proposed formula are used to quantify the degree of microscopic anisotropy of the target, which can provide a direct strategy for tissue polarization measurements by absorbing acoustic waves of polarized microwaves.
本发明的另一方面也在于提供了一种可用于线偏振微波热声成像的装置系统。Another aspect of the present invention also provides a device system that can be used for linearly polarized microwave thermoacoustic imaging.
附图说明:Description of drawings:
图1为本发明线偏振微波热声层析成像装置结构示意图。图中包括计算机,数据采集系统,前置放大器,超声换能器,微波激发源。微波发射天线。FIG. 1 is a schematic structural diagram of a linearly polarized microwave thermoacoustic tomography apparatus according to the present invention. The figure includes a computer, a data acquisition system, a preamplifier, an ultrasonic transducer, and a microwave excitation source. Microwave transmitting antenna.
图2为本发明验证PMTA可行性的实验图。FIG. 2 is an experimental diagram for verifying the feasibility of PMTA according to the present invention.
具体实施方式:Detailed ways:
如图1所示,本发明提供了一种线偏振微波热声成像装置,装置包括顺次连接的计算机,微波激发源、同轴电缆,微波天线也即偶极天线、待测样品油槽,超声换能器、信号放大器、数据采集系统也即为高速数据采集卡,计算机中具有控制脉冲微波发生器系统工作软件,以及图像重建软件,以及数据采集控制程序软件Labview,图像重建软件为MATLAB软件;使用具有脉冲宽度为550ns,中心频率为3GHz和重复频率为10Hz、峰值功率70Kw的线偏振微波作为微波激发源,发出的微波通过同轴电缆耦合到偶极天线,发出线偏振微波,偶极天线长60mm宽60mm高度为45mm;超声换能器孔径尺寸120mm,主频为5MHz,60%带宽,高速数据采集卡的采样率为50MHz,具有2路数据,偶极天线的正上方为油槽,油槽中具有超声耦合液,进行样品热声信号测量时,样品浸没并固定在油槽中的超声耦合液中,微波脉冲天线固定于样品正下方;偶极天线发出的脉冲微波辐射于样品上;超声换能器浸入去超声耦合液中用于接收样品被脉冲微波激发出的热声信号,超声耦合液为室温下的变压器油;计算机内的LABVIEW软件可以控制数据采集平台,MATLAB软件程序进行数据处理的;所述高速数字采集卡采集到的探测脉冲产生的热声信号,并且通过旋转偶极天线,获得了在不同偏振方向上具有相似能量密度的线性偏振微波,改变微波偏振取向φ和样品轴取向之间的角度分别为0,45,90,135,分别进行热声信号采集,通过应用四个线偏振微波作为激发源,基于矢量微波吸收定量检测目标的微观各向异性,利用MATLAB软件程序通过画弧投影-最大值投影算法得到所测样品的微波吸收重建图像,而本发明也首次提出重建图像所采用的公式是:得到该公式的主要原理过程为:当介电各向异性靶被线偏振微波激发时,通过假设靶是单轴的,微波和各向异性靶之间的相互作用强烈地取决于线偏振微波取向φ和靶的目标轴取向之间的角度。这导致平行于和垂直于目标轴的方向之间的微波吸收的明显差异,偏振取向依赖的微波吸收,然后可以将介电各向异性靶的与偏振方向相关的微波吸收系数写成As shown in FIG. 1 , the present invention provides a linearly polarized microwave thermoacoustic imaging device, which includes a computer connected in sequence, a microwave excitation source, a coaxial cable, a microwave antenna that is a dipole antenna, a sample oil tank to be tested, an ultrasonic The transducer, signal amplifier, and data acquisition system are also high-speed data acquisition cards. The computer has working software for controlling the pulsed microwave generator system, as well as image reconstruction software, as well as data acquisition control program software Labview, and the image reconstruction software is MATLAB software; A linearly polarized microwave with a pulse width of 550ns, a center frequency of 3GHz, a repetition frequency of 10Hz, and a peak power of 70Kw is used as the microwave excitation source, and the emitted microwave is coupled to a dipole antenna through a coaxial cable, and a linearly polarized microwave is emitted, and the dipole antenna Length 60mm, width 60mm, height 45mm; ultrasonic transducer aperture size is 120mm, main frequency is 5MHz, 60% bandwidth, sampling rate of high-speed data acquisition card is 50MHz, with 2 channels of data, directly above the dipole antenna is the oil tank, the oil tank There is an ultrasonic coupling liquid in it. When measuring the thermoacoustic signal of the sample, the sample is immersed and fixed in the ultrasonic coupling liquid in the oil tank, and the microwave pulse antenna is fixed directly under the sample; the pulsed microwave emitted by the dipole antenna is radiated on the sample; The energizer is immersed in the ultrasonic decoupling fluid to receive the thermoacoustic signal excited by the pulsed microwave. The ultrasonic coupling fluid is transformer oil at room temperature; the LABVIEW software in the computer can control the data acquisition platform, and the MATLAB software program performs data processing. ; The thermoacoustic signal generated by the detection pulse collected by the high-speed digital acquisition card, and by rotating the dipole antenna, linearly polarized microwaves with similar energy densities in different polarization directions are obtained, and the microwave polarization orientation φ and sample axis are changed. The angles between the orientations are 0, 45, 90, and 135, respectively, and the thermoacoustic signals are collected respectively. By applying four linearly polarized microwaves as excitation sources, the microscopic anisotropy of the target is quantitatively detected based on vector microwave absorption, and the MATLAB software program is used. The microwave absorption reconstruction image of the measured sample is obtained by the arc projection-maximum projection algorithm, and the present invention also proposes for the first time that the formula used to reconstruct the image is: The main principle process for obtaining this formula is: when a dielectric anisotropic target is excited by a linearly polarized microwave, by assuming that the target is uniaxial, the interaction between the microwave and the anisotropic target strongly depends on the linearly polarized microwave orientation φ and the target axis of the target The angle between orientations. This results in a clear difference in microwave absorption between directions parallel to and perpendicular to the target axis, polarization orientation dependent microwave absorption, and the polarization orientation dependent microwave absorption coefficient for a dielectric anisotropic target can then be written as
这里,ε||和ε⊥分别是平行于和垂直于目标轴的方向的吸收系数。对于满足ε||=ε⊥的各向同性目标,等式(1)简化为PMTA成像原理,吸收常数为Here, ε || and ε⊥ are the absorption coefficients in the directions parallel and perpendicular to the target axis, respectively. For an isotropic target satisfying ε || =ε ⊥ , equation (1) is simplified to the PMTA imaging principle, and the absorption constant is
为了简化问题,我们定义了因此,线偏振微波激发的各向异性目标的TA信号幅度可写为To simplify the problem, we define Therefore, the TA signal amplitude of an anisotropic target excited by a linearly polarized microwave can be written as
这里,F(φ)是线性偏振微波的能量密度,Γ是格林爱森参数,η是热转换效率,上式表明,对于具有一定微波偏振方向的入射线偏振微波,TA信号幅度与θ高度相关,可用于提取各向异性材料的结构特征;为了量化目标的各向异性,通过应用四个线性偏振微波作为激发源,在PMTA中提出了一个新参数。根据斯托克斯形式,微波的偏振态可以用斯托克斯矢量描述为Here, F(φ) is the energy density of linearly polarized microwaves, Γ is the Green Eisen parameter, and η is the thermal conversion efficiency. The above formula shows that for incident line-polarized microwaves with a certain microwave polarization direction, the TA signal amplitude is highly correlated with θ , which can be used to extract structural features of anisotropic materials; to quantify the anisotropy of the target, a new parameter is proposed in PMTA by applying four linearly polarized microwaves as excitation sources. According to the Stokes form, the polarization state of the microwave can be described by the Stokes vector as
其中,四个斯托克斯参数表示由具有不同取向的六个微波强度。IH和IV是水平(0°)和垂直(90°)线性偏振;IP和IM是45°和-45°线性偏振;IR和IL是左右圆偏振。然后,微波的线性偏振度(DLP)可以定义为Among them, four Stokes parameters are represented by six microwave intensities with different orientations. I H and IV are horizontal (0°) and vertical (90°) linear polarizations; IP and IM are 45° and -45° linear polarizations; IR and IL are left and right circular polarizations. Then, the degree of linear polarization (DLP) of the microwave can be defined as
与斯托克斯形式主义类似,并且假设目标是单轴的,目标的各向异性程度(DOA)可以定义为Similar to Stokes formalism, and assuming that the target is uniaxial, the degree of anisotropy (DOA) of the target can be defined as
其中,QTA=IH-TA-IV-TA,UTA=IP-TA-IM-TA,和ITA=IH-TA+IV-TA。IH-TA,IV-TA,IP-TA和IM-TA对应于线性偏振微波激发的TA信号幅度,偏振方向分别为0°,90°,45°和135°。对于单轴目标,DOA的值在0和1之间。因此,目标的各向异性就可以通过DOA来量化。通过前述的检测计算原理,本发明定量检测目标的微观各向异性的线偏振微波热声测量方法,包括以下步骤:where Q TA =I H-TA -I V-TA , U TA = IP-TA -I M-TA , and I TA =I H-TA +I V-TA . IH-TA , IV-TA , IP-TA and IM-TA correspond to the TA signal amplitudes excited by linearly polarized microwaves with polarization directions of 0°, 90°, 45° and 135°, respectively. For single-axis targets, DOA has a value between 0 and 1. Therefore, the anisotropy of the target can be quantified by DOA. Through the aforementioned detection and calculation principle, the linearly polarized microwave thermoacoustic measurement method for quantitatively detecting the microscopic anisotropy of the target of the present invention comprises the following steps:
(1)线偏振微波经由同轴电缆耦合天线发射中心频率为3GHz、重复频率10GHz的线偏振脉冲微波,线偏振脉冲微波通过长60mm宽60mm高度为45mm的偶极天线调整后输出;(1) The linearly polarized microwave transmits a linearly polarized pulsed microwave with a center frequency of 3 GHz and a repetition frequency of 10 GHz through a coaxial cable coupling antenna, and the linearly polarized pulsed microwave is adjusted and output through a dipole antenna with a length of 60 mm, a width of 60 mm and a height of 45 mm;
(2)线偏振微波通过LabView控制面板可以实现10HZ的微波脉冲输出重复频率;(2) The linearly polarized microwave can achieve a microwave pulse output repetition frequency of 10HZ through the LabView control panel;
(3)设置微波偏振取向φ和样品轴取向之间的角度为0度,样品受热膨胀,激发热声信号;(3) Set microwave polarization orientation φ and sample axis The angle between the orientations is 0 degrees, the sample is thermally expanded, and the thermoacoustic signal is excited;
(4)热声信号经过耦合液被超声换能器检测,后经过信号放大器放大然后被高速数字采集卡采集并保存至计算机。在此过程中,计算机控制步进电机逐点移动样品,并且步进电机每一次移动,高速数字采集卡进行一次信号采集。(4) The thermoacoustic signal is detected by the ultrasonic transducer through the coupling liquid, then amplified by the signal amplifier, and then collected by the high-speed digital acquisition card and saved to the computer. During this process, the computer controls the stepper motor to move the sample point by point, and each time the stepper motor moves, the high-speed digital acquisition card performs a signal acquisition.
(5)改变微波偏振取向φ和样品轴取向之间的角度分别为45,90,135,重复(4)进行热声信号采集。(5) Change the microwave polarization orientation φ and the sample axis The angles between the orientations were 45, 90, and 135, respectively, and (4) was repeated for thermoacoustic signal acquisition.
(6)在计算机上对采集到的数据进行处理计算,计算方法第一步对每一行用画弧投影,第二步对每一行进行最大值投影得到热声重建图像,如图2(b)所示。最后,用得到的0,45,90,135度的数据用公式(6) Process and calculate the collected data on the computer. The first step of the calculation method is to use arc projection for each row, and in the second step, each row is projected to the maximum value to obtain a thermoacoustic reconstruction image, as shown in Figure 2(b) shown. Finally, use the obtained data of 0, 45, 90, 135 degrees with the formula
其中,QTA=IH-TA-IV-TA,UTA=IP-TA-IM-TA,和ITA=IH-TA+IV-TA。IH-TA,IV-TA,IP-TA和IM-TA对应于线性偏振微波激发的TA信号幅度,偏振方向分别为0°,90°,45°和135°。 where Q TA =I H-TA -I V-TA , U TA = IP-TA -I M-TA , and I TA =I H-TA +I V-TA . IH-TA , IV-TA , IP-TA and IM-TA correspond to the TA signal amplitudes excited by linearly polarized microwaves with polarization directions of 0°, 90°, 45° and 135°, respectively.
得到各向异性度的图像,也就是DOA image。Get the image of the degree of anisotropy, that is, the DOA image.
本发明为了证实可行性,也提供了同在具有不偏振取向的一系列线性偏振微波的激发下成像具有强介电各向异性性质的碳纤维,图2(a)显示了样品照片。黑色虚线是碳纤维样品的主轴方向和双箭头是指入射线偏振微波的电场矢量偏振方向,图2b为线偏振微波角度分别为0度,45度,90度,135度,180度的热声重建图,图中可以看出,样品的热声重建随着角度的变化而有所变化,图2(c)为图2(b)的热声信号统计结果,图2c的5个点的热声信号统计值分别对应图2b的5个角度的热声重建图,从结果上更是清楚看出不同线偏振角度下的热声幅值的变化差异,图2d的各向异性度图是由图2b的0度,45度,90度,135度的热声图像重建图用我们推导出的各向异性度参数公式得到,从图中可以看出碳纤维的各向异性度为0.75。In order to prove the feasibility, the present invention also provides imaging of carbon fibers with strong dielectric anisotropy under the excitation of a series of linearly polarized microwaves with unpolarized orientations. Figure 2(a) shows a sample photo. The black dotted line is the principal axis direction of the carbon fiber sample and the double arrows refer to the electric field vector of the incident ray polarized microwave Polarization direction, Figure 2b is the thermoacoustic reconstruction diagram of the linearly polarized microwave angles of 0 degrees, 45 degrees, 90 degrees, 135 degrees, and 180 degrees. It can be seen from the figure that the thermoacoustic reconstruction of the sample varies with the angle. Figure 2(c) shows the statistical results of the thermoacoustic signals in Figure 2(b). The statistical values of the thermoacoustic signals at the five points in Figure 2c correspond to the thermoacoustic reconstruction maps of the five angles in Figure 2b, respectively. From the results It is even more clear to see the difference in the thermoacoustic amplitudes under different linear polarization angles. The anisotropy map in Figure 2d is reconstructed from the thermoacoustic images of 0, 45, 90, and 135 degrees in Figure 2b. The anisotropy parameter formula we derived As a result, it can be seen from the figure that the degree of anisotropy of the carbon fiber is 0.75.
综上所述,我们提出了一种偏振微波热声成像(PMTA),通过应用四个线性偏振微波作为激发源,来定量检测目标的微观各向异性。与将目标视为各向同性吸收剂的传统微波热声成像装置相比,PMTA允许我们定量检测目标的各向异性特征,在微波吸收之上新提出的参数值在0和1之间,能够用新提出的参数值0到1来量化目标的微观各向异性程度。该方法的可行性通过介电各向异性样品验证,PMTA方法为组织偏振测量提供了一种有效且直接的策略,为生物成像和材料检查预先设定了很大的潜力。In summary, we propose a polarized microwave thermoacoustic imaging (PMTA) to quantitatively detect the microscopic anisotropy of a target by applying four linearly polarized microwaves as excitation sources. Compared with conventional microwave thermoacoustic imaging setups that treat the target as an isotropic absorber, PMTA allows us to quantitatively detect the anisotropic features of the target, with the newly proposed parameter values between 0 and 1 on top of microwave absorption, capable of The newly proposed parameter values 0 to 1 are used to quantify the degree of microscopic anisotropy of the target. The feasibility of this method is verified by dielectric anisotropy samples, and the PMTA method provides an efficient and straightforward strategy for tissue polarization measurements, presetting a great potential for bioimaging and material inspection.
以上所述,仅为本发明较佳的具体实施方式,但本发明的保护范围并不局限于此,任何熟悉本技术领域的技术人员在本发明揭露的技术范围内,根据本发明的技术方案及其发明构思加以等同替换或改变,都应涵盖在本发明的保护范围之内。The above description is only a preferred embodiment of the present invention, but the protection scope of the present invention is not limited to this. The equivalent replacement or change of the inventive concept thereof shall be included within the protection scope of the present invention.
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