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CN112544968A - Whitening and freckle removing composition and preparation method thereof - Google Patents

Whitening and freckle removing composition and preparation method thereof Download PDF

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Publication number
CN112544968A
CN112544968A CN202011399632.1A CN202011399632A CN112544968A CN 112544968 A CN112544968 A CN 112544968A CN 202011399632 A CN202011399632 A CN 202011399632A CN 112544968 A CN112544968 A CN 112544968A
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Prior art keywords
extract
yeast
whitening
yeast extract
removing composition
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CN202011399632.1A
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Inventor
张志勇
白冠辉
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Zhengnian Pharmaceutical Technology Guangzhou Co ltd
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Zhengnian Pharmaceutical Technology Guangzhou Co ltd
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Priority to CN202011399632.1A priority Critical patent/CN112544968A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L31/00—Edible extracts or preparations of fungi; Preparation or treatment thereof
    • A23L31/10—Yeasts or derivatives thereof
    • A23L31/15—Extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/14—Yeasts or derivatives thereof
    • A23L33/145—Extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Life Sciences & Earth Sciences (AREA)
  • Mycology (AREA)
  • Health & Medical Sciences (AREA)
  • Nutrition Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Microbiology (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

The invention discloses a whitening and freckle-removing composition, which is used in the field of food or health-care food and can lighten the skin to achieve the effects of whitening and removing freckles. The whitening and freckle-removing composition comprises a yeast extract and an astaxanthin extract. The invention also provides a preparation method of the whitening and freckle-removing composition, 1) weighing 1-40 parts by weight of yeast extract and 0.01-5 parts by weight of astaxanthin extract, wherein the granularity of the yeast extract and the astaxanthin extract is 80-150 meshes; 2) adding yeast extract and astaxanthin extract into three-dimensional mixer at rotation speed of 10-14rpm for 15-20 min, and mixing. The whitening and freckle-removing composition is used for food or health food, acts on the whole body through oral administration, and inhibits the activity of tyrosinase and the formation of free radicals, so that the skin becomes light and the whitening and freckle-removing effects are achieved. The composition does not contain any cosmetic-grade components, all the components are food raw materials or food additives, and the composition has no toxic or side effect.

Description

Whitening and freckle removing composition and preparation method thereof
Technical Field
The invention belongs to the field of biological medicines, and particularly relates to a whitening and freckle-removing composition and a preparation method thereof.
Background
The pigment substances of the skin include melanin, carotene, etc., and melanin is produced by melanocytes in the skin and is a main factor determining the color of the skin. The synthesis of melanin must involve 3 substances, tyrosine, the main raw material for synthesizing melanin, tyrosinase, the main rate-limiting enzyme for catalyzing the conversion of tyrosine into melanin, and oxygen which participates in the catalytic process.
The skin is the protective barrier of the outermost layer of the human body and is composed of a plurality of layers of tissues, wherein the outermost layer is the horny layer composed of dead horny cells, the horny layer is thick and compact, the invasion of bacteria and harmful chemical substances can be effectively prevented, and the surface of the horny layer is also provided with a lipid film, so that the skin can be smooth and glossy, and the evaporation of water in the body can be prevented. The presence of the stratum corneum and lipid membranes imparts water impermeability to the skin. The natural protective mechanism of human skin allows only a very small amount of water and fat-soluble substances to pass through. Many water-soluble substances in cosmetics, such as vitamin C and macromolecular proteins, cannot penetrate through the stratum corneum or the pilosebaceous glands to be absorbed by the skin. Due to the barrier effect of human skin, substances coated on the skin surface are difficult to absorb, so the external skin whitening product has slow effect and limited effect, and the effect is not systemic, is only local and is limited by time and region in use
Disclosure of Invention
The invention aims to provide a whitening and freckle-removing composition which is used in the field of food or health-care food and can lighten the skin to achieve the effects of whitening and removing freckles.
In addition, a preparation method of the whitening and freckle-removing composition is also provided.
A whitening and speckle removing composition comprises yeast extract and astaxanthin extract.
Preferably, the whitening and freckle-removing composition comprises the following components in parts by weight: 1-40 parts of yeast extract and 0.01-5 parts of astaxanthin extract.
More preferably, the whitening and freckle-removing composition comprises the following components in parts by weight: 25-30 parts of yeast extract and 2-3 parts of astaxanthin extract.
Further preferably, the whitening and freckle-removing composition comprises the following components in parts by weight: 25-30 parts of yeast extract and 2.5 parts of astaxanthin extract.
Preferably, the yeast extract is selected from one or more of yeast fermentation powder, yeast extract and glutathione-rich yeast powder, and more preferably, the yeast is glutathione-rich yeast.
Wherein the astaxanthin extract is haematococcus pluvialis powder.
Wherein the yeast extract is prepared by the following method:
adding yeast into water to prepare yeast suspension with dry matter content of 30-40 wt%, adding papain with addition amount of 0.05-0.1 wt% of yeast, heating to 60-70 deg.C, maintaining for 4-5 hr, inactivating at 90 deg.C for 15min, centrifuging at 3000rpm for 30min, collecting lower layer solid, and drying to obtain yeast extract.
Preferably, the yeast is glutathione-Rich yeast (Rich glutathione yeast).
Preferably, the weight ratio of the reduced glutathione in the yeast extract is more than or equal to 15 percent
Preferably, the particle size of the yeast extract and the astaxanthin extract is 80-150 mesh.
A preparation method for preparing the whitening and freckle-removing composition,
1) weighing 1-40 parts by weight of yeast extract and 0.01-5 parts by weight of astaxanthin extract, wherein the particle sizes of the yeast extract and the astaxanthin extract are 80-150 meshes;
2) adding yeast extract and astaxanthin extract into three-dimensional mixer at rotation speed of 10-14rpm for 15-20 min, and mixing.
Compared with the prior art, the whitening and freckle-removing composition is used for food or health food, acts on the whole body through oral administration, and inhibits the activity of tyrosinase and the formation of free radicals, so that the skin becomes light and the whitening and freckle-removing effects are achieved. The composition does not contain any cosmetic-grade components, all the components are food raw materials or food additives, and the composition has no toxic or side effect.
Detailed Description
The present invention will be described in further detail with reference to specific embodiments in order to make the technical field better understand the scheme of the present invention.
Description of the raw materials
Astaxanthin extract: haematococcus pluvialis powder purchased from bioscience, Spanish Gagnep, Inc., with astaxanthin content of 3 wt%, respectively sieving to obtain 60 mesh, 80 mesh, 100 mesh, 150 mesh and 180-mesh Haematococcus pluvialis powder;
glutathione-Rich yeast (Rich glutaminone yeast): purchased from bio-pharmaceuticals, ltd, golden city, Shandong;
papain: CAS NO 9001-73-4, English name Papain, specification of 10 ten thousand U/g, Shanxi Gaoshang biological medicine Co., Ltd;
the yeast extract is prepared by the following method:
adding glutathione-rich yeast into water to prepare yeast suspension, wherein the dry matter content of the yeast suspension is 35 wt%, adding papain, the adding amount of the papain is 0.05 wt% of the yeast dosage, heating to 60-70 deg.C, maintaining for 4 hr, inactivating at 90 deg.C for 15min, centrifuging at 3000rpm for 30min, collecting the lower layer solid, and drying to obtain yeast extract.
Pulverizing, and sieving to obtain yeast extracts of 60 mesh, 80 mesh, 100 mesh, 150 mesh and 180 mesh.
Example 1
1) Weighing the yeast extract and the haematococcus pluvialis powder according to the weight parts shown in the table 1, wherein the granularity of the yeast extract and the haematococcus pluvialis powder is shown in the table 1;
2) the yeast extract and haematococcus pluvialis powder were put into a three-dimensional mixer at a rotation speed of 12rpm for 17 minutes to allow the two to be uniformly mixed.
Example 2
1) Weighing the yeast extract and the haematococcus pluvialis powder according to the weight parts shown in the table 1, wherein the granularity of the yeast extract and the haematococcus pluvialis powder is shown in the table 1;
2) the yeast extract and haematococcus pluvialis powder are put into a three-dimensional mixer, the rotating speed is 10rpm, the mixing time is 20 minutes, and the two are uniformly mixed.
Example 3
1) Weighing the yeast extract and the haematococcus pluvialis powder according to the weight parts shown in the table 1, wherein the granularity of the yeast extract and the haematococcus pluvialis powder is shown in the table 1;
2) the yeast extract and haematococcus pluvialis powder were put into a three-dimensional mixer at 14rpm for 15 minutes to mix them uniformly.
Comparative example 1
Glutathione: reduced glutathione, purchased from Shandong Zoozhao Biotech Co., Ltd, model JH, CAS No.70-18-8
Comparative example 2
30kg of lycium ruthenicum extract, 2.5 kg of rutin, 100 kg of tea polyphenol, 12.5 kg of glutathione, 50 kg of L-cysteine, 50 kg of ellagic acid, 40 kg of ceramide, 0.16 kg of lycopene, 30kg of vitamin C and 0.5 kg of vitamin E are fully and uniformly stirred.
Comparative example 3
Haematococcus pluvialis powder, manufactured by Sienna Gagnep Biotech Ltd, having an astaxanthin content of 3 wt% and 100 mesh.
Comparative example 4
The yeast extract prepared by the invention is 100 meshes.
Comparative examples 5 to 8
1) Weighing the yeast extract and the haematococcus pluvialis powder according to the weight parts shown in the table 1, wherein the granularity of the yeast extract and the haematococcus pluvialis powder is shown in the table 1;
2) the yeast extract and haematococcus pluvialis powder are put into a three-dimensional mixer, the rotating speed is 10rpm, the mixing time is 20 minutes, and the two are uniformly mixed.
Table 1 formulation table of the examples
Haematococcus pluvialis powder Haematococcus pluvialis powder particle size Yeast extract Particle size of yeast extract
Example 1 5 parts by weight of 80 mesh 40 parts by weight of 150 mesh
Example 2 2 parts by weight of 100 mesh 20 parts by weight of 100 mesh
Example 3 1 part by weight 150 mesh 10 parts by weight 80 mesh
Comparative example 5 2 parts by weight of 60 mesh 20 parts by weight of 60 mesh
Comparative example 6 2 parts by weight of 60 mesh 20 parts by weight of 180 mesh
Comparative example 7 2 parts by weight of 180 mesh 20 parts by weight of 60 mesh
Comparative example 8 2 parts by weight of 180 mesh 20 parts by weight of 180 mesh
The compositions obtained in examples 1 to 3 and comparative examples 1 to 8 were sieved with a 60-mesh sieve to obtain capsule contents, and the capsule contents were placed in a hopper of a capsule machine to prepare capsules having a specification of 0.4 g/capsule.
Example 4
(1) Preparing a mixed material: weighing 20kg of yeast extract and 2kg of astaxanthin. Making yeast extract into soft material with 75% ethanol, granulating with swing granulator, sieving with 14 mesh sieve, and drying to obtain granule with water content of about 3.5%. And then uniformly mixing the astaxanthin white particles to obtain a mixed material.
(2) Preparation of tablets: the resulting blend was placed in the hopper of a tablet press to make tablets of 1.0 g/pellet size.
Example 5
(1) Preparing feed liquid: 10kg of yeast extract, 1kg of astaxanthin and 30kg of purified water were weighed. Adding the yeast extract and the astaxanthin into purified water, stirring to completely dissolve the yeast extract and the astaxanthin, and uniformly stirring to obtain a feed liquid.
(2) Preparing oral liquid: the obtained feed liquid is made into oral liquid with the specification of 50 mL/bottle by an oral liquid capping machine.
The obtained capsules prepared in examples 1 to 3 and comparative examples 1 to 8, the tablets prepared in example 4, and the oral liquid prepared in example 5 were subjected to the following whitening effect test.
1. Test samples and dosages:
examples 1-3 and comparative examples 1-8 (2 capsules per day), example 4 (2 tablets per day), example 5 (2 bottles per day), physiological saline (100 mL per day).
2. Selecting a crowd:
age interval: 25-45 years old; sex: 50 men and women respectively; and (3) testing season: 10-12 months
3. The experimental process comprises the following steps:
in each group of experiments, a test subject is selected to be tested, the left arm and the right arm of the test subject are selected to be used as data acquisition areas, technicians use a test instrument to perform initial value data acquisition, and the tested part cannot use any cosmetics during the experiment. Subjects ate the test samples for eight weeks continuously and data is collected periodically during the test period. And (4) carrying out statistical analysis on the acquisition result, carrying out paired t test and calculating the mean value.
Relative initial value change ratio (%) - (Tn-T0)/T0X 100
Relative blank change ratio (%) - (Tn-T0) - (Kn-K0) ]/T0 × 100
In the formula: tn represents the value of the test site
T0 denotes the initial value of the test site
Kn represents blank group number
K0 denotes blank set start value
4. Testing instrument
Skin melanin and heme tester Mexameter MX18 (Germany CK Co.)
5. Test index
The MI value represents the index of melanin, the measuring range of the instrument is 0-999, and the higher the measuring value is, the higher the melanin content in the skin is.
6. The results are shown in Table 2
TABLE 2 values of mean MI over time of the test population
Figure BDA0002816575180000051
Figure BDA0002816575180000061
As shown in the results in Table 2, the whitening and freckle-removing composition prepared by the invention is remarkably better than that prepared by singly using haematococcus pluvialis powder and a yeast extract, and has obvious synergistic effect on whitening effect and lasting effect.
Stability test
After the compositions of examples 1 to 5 were exposed to the air for 1 month, the whitening effect test was performed according to the above-mentioned method, and the measured MI values are shown in Table 3
Table 3 whitening efficacy test results (MI value) of the composition after one month exposure to air
1 week 2 weeks 3 weeks 4 weeks 5 weeks 6 weeks 7 weeks 8 weeks
Example 1 426 416 413 389 365 333 315 309
Example 2 428 417 413 386 363 325 312 308
Example 3 434 418 415 395 368 334 321 311
Example 4 429 420 419 398 374 351 331 315
Example 5 421 413 413 402 379 370 341 331
Physiological saline 415 413 415 417 416 414 416 416
When the granularity of the haematococcus pluvialis powder and the yeast extract is between 80 and 150 meshes, the whitening composition has better effect, and the whitening and freckle removing composition prepared from the haematococcus pluvialis powder and the yeast extract has good stability when the granularity is uniform.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims (9)

1. A whitening and freckle-removing composition is characterized by comprising a yeast extract and an astaxanthin extract.
2. The whitening and freckle-removing composition according to claim 1, which is characterized by comprising the following components in parts by weight: 1-40 parts of yeast extract and 0.01-5 parts of astaxanthin extract.
3. The whitening spot-removing composition of claim 2, wherein:
the yeast extract is selected from one or more than two of yeast fermentation powder, yeast extract and glutathione-rich yeast powder.
4. The whitening spot-removing composition of claim 3, wherein:
the astaxanthin extract is haematococcus pluvialis powder.
5. The whitening spot-removing composition of claim 4, wherein:
the yeast extract is prepared by the following method:
adding yeast into water to prepare yeast suspension with dry matter content of 30-40 wt%, adding papain with addition amount of 0.05-0.1 wt% of yeast, heating to 60-70 deg.C, maintaining for 4-5 hr, inactivating at 90 deg.C for 15min, centrifuging at 3000rpm for 30min, collecting lower layer solid, and drying to obtain yeast extract.
6. The whitening spot-removing composition of claim 5, wherein:
the yeast is glutathione-rich yeast.
7. The whitening spot-removing composition of claim 6, wherein:
the weight ratio of the reduced glutathione in the yeast extract is more than or equal to 15 percent.
8. The whitening spot-removing composition of claim 7, wherein:
the particle size of the yeast extract and the astaxanthin extract is 80-150 meshes.
9. A method for preparing the whitening and spot-removing composition according to any one of claims 1 to 8, which is characterized by comprising the following steps:
1) weighing 1-40 parts by weight of yeast extract and 0.01-5 parts by weight of astaxanthin extract, wherein the particle sizes of the yeast extract and the astaxanthin extract are 80-150 meshes;
2) adding yeast extract and astaxanthin extract into three-dimensional mixer at rotation speed of 10-14rpm for 15-20 min, and mixing.
CN202011399632.1A 2020-12-04 2020-12-04 Whitening and freckle removing composition and preparation method thereof Pending CN112544968A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113115876A (en) * 2021-04-28 2021-07-16 北京逯博士行为医学科技研究院有限公司 Whitening composition for strengthening skin and strengthening body

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1748573A (en) * 2005-10-10 2006-03-22 华南理工大学 Nutritious food containing astaxanthin and its preparation method
WO2010112071A1 (en) * 2009-04-01 2010-10-07 Phf S.A. Combination of astaxanthin, antioxidants and colouring agents with sunscreen effect to be administered orally
JP2011032171A (en) * 2009-07-29 2011-02-17 Fuji Chem Ind Co Ltd Skin whitening composition
JP2012153636A (en) * 2011-01-25 2012-08-16 Fuji Chem Ind Co Ltd Glutathione production enhancer
CN104757560A (en) * 2014-08-11 2015-07-08 四川安益生物科技有限公司 Glutathione yeast enzymolysis solution composition and preparation method thereof
CN108813436A (en) * 2018-07-10 2018-11-16 曾杨列 Nutrition fortifier with strengthen immunity and the application in health leisure food
CN109662231A (en) * 2019-01-09 2019-04-23 西安源森生物科技有限公司 A kind of solid beverage and preparation method thereof with anti-oxidation efficacy
CN110037257A (en) * 2019-03-29 2019-07-23 广东澳思瑞雅健康美容生物科技有限公司 A kind of formula and preparation method of immunological regulation and enhancing physical strength

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1748573A (en) * 2005-10-10 2006-03-22 华南理工大学 Nutritious food containing astaxanthin and its preparation method
WO2010112071A1 (en) * 2009-04-01 2010-10-07 Phf S.A. Combination of astaxanthin, antioxidants and colouring agents with sunscreen effect to be administered orally
JP2011032171A (en) * 2009-07-29 2011-02-17 Fuji Chem Ind Co Ltd Skin whitening composition
JP2012153636A (en) * 2011-01-25 2012-08-16 Fuji Chem Ind Co Ltd Glutathione production enhancer
CN104757560A (en) * 2014-08-11 2015-07-08 四川安益生物科技有限公司 Glutathione yeast enzymolysis solution composition and preparation method thereof
CN108813436A (en) * 2018-07-10 2018-11-16 曾杨列 Nutrition fortifier with strengthen immunity and the application in health leisure food
CN109662231A (en) * 2019-01-09 2019-04-23 西安源森生物科技有限公司 A kind of solid beverage and preparation method thereof with anti-oxidation efficacy
CN110037257A (en) * 2019-03-29 2019-07-23 广东澳思瑞雅健康美容生物科技有限公司 A kind of formula and preparation method of immunological regulation and enhancing physical strength

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘会平 等: "白藜芦醇-葡萄多酚复方口服液的抗氧化活性和美白作用评价", 《现代食品科技》 *
黄海: "啤酒废酵母多糖及谷胱甘肽提取工艺的研究", 《中国优秀硕士学位论文全文数据库（电子期刊）》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113115876A (en) * 2021-04-28 2021-07-16 北京逯博士行为医学科技研究院有限公司 Whitening composition for strengthening skin and strengthening body

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