CN112495301B - A manufacturing device for pharmaceutical excipients - Google Patents
A manufacturing device for pharmaceutical excipients Download PDFInfo
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- CN112495301B CN112495301B CN202110119029.1A CN202110119029A CN112495301B CN 112495301 B CN112495301 B CN 112495301B CN 202110119029 A CN202110119029 A CN 202110119029A CN 112495301 B CN112495301 B CN 112495301B
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- cooling tower
- fan
- separator
- raw material
- material tank
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种药用辅料的制造设备，主要用于制备药用辅料硬脂酸和十六十八醇；包括原料罐、输送泵、冷却塔、分离器、风机和冷却器；所述冷却塔顶部出风口通过分离器连接风机，所述风机通过冷却器连接冷却塔的下部进风口，形成空气循环；所述冷却塔底部设有出料口；所述冷却塔内部通过管道安装有喷头，所述喷头通过输送泵与原料罐相连。本发明设备产品制造过程物料配方连续可调，不需要前配料；生产过程安全性高，风机前分离器基本没有细粉。
The invention discloses a manufacturing equipment for pharmaceutical excipients, which is mainly used for preparing pharmaceutical excipients stearic acid and cetostearyl alcohol; it includes a raw material tank, a delivery pump, a cooling tower, a separator, a fan and a cooler; the air outlet at the top of the cooling tower is connected to the fan through a separator, and the fan is connected to the lower air inlet of the cooling tower through a cooler to form an air circulation; a discharge port is provided at the bottom of the cooling tower; a nozzle is installed inside the cooling tower through a pipeline, and the nozzle is connected to the raw material tank through a delivery pump. The material formula of the manufacturing process of the equipment product of the invention is continuously adjustable, and no pre-batch is required; the production process is highly safe, and there is basically no fine powder in the separator before the fan.
Description
Technical Field
The invention relates to a manufacturing device of pharmaceutical excipients, which is particularly suitable for preparing small granular stearic acid and cetostearyl alcohol.
Background
The medicinal small granular cetostearyl alcohol has large specific surface area, is easy to be mixed with other materials uniformly, and is widely applied to the pharmaceutical industry. At present, the pharmaceutical grade cetostearyl alcohol is mainly prepared by firstly proportioning and melting cetyl alcohol and stearyl alcohol according to a formula, uniformly mixing, and then cooling by a granulator to prepare products in the shapes of small beads, semi-spheres or flakes and the like. The process has four major defects, namely, firstly, the freezing point is reduced when two different materials are mixed, so that the product is easy to bond in summer, particularly, the product is particularly obvious for small granular products, secondly, in order to prevent the material from bonding, the particle size can be improved, but the particle is not easy to solidify when the particle is large, or the temperature of the product with poor particle cooling effect is higher, equipment is required to be increased for deep cooling, the using effect is greatly influenced by the particle, thirdly, the material proportioning and mixing operation is complex, and fourthly, the product size distribution is uneven, and more products containing fine powder are easy to generate safety problems and caking problems.
The three types of medicinal stearic acid products are respectively 50 (stearic acid content is 40-60%), 70 (stearic acid content is 60-80%) and 95, and the three types of medicinal stearic acid products are uniformly mixed and then produced at present. There are also various disadvantages, first, freezing point depression; thirdly, the product fine powder multiparticulates are unevenly adhered to the tower wall, the maintenance cost is high, and safety problems such as dust explosion and the like are easily caused.
Disclosure of Invention
Aiming at the defects of the existing manufacturing process and manufacturing equipment, the invention provides the manufacturing equipment of the pharmaceutical auxiliary material, which is particularly suitable for preparing small granular stearic acid and cetostearyl alcohol, and the high-sphericity small granular product with the diameter of 0.05-0.3mm is prepared, the product is not easy to melt and agglomerate in summer, the material proportioning is realized automatically, and the continuous operation can be realized.
The technical scheme adopted by the invention is as follows:
The manufacturing equipment of the pharmaceutical auxiliary materials comprises a raw material tank, a delivery pump, a cooling tower, a separator, a fan and a cooler, wherein an air outlet at the top of the cooling tower is connected with the fan through the separator, the fan is connected with an air inlet at the lower part of the cooling tower through the cooler to form air circulation, a discharge hole is formed in the bottom of the cooling tower, a spray head is installed in the cooling tower through a pipeline, and the spray head is connected with the raw material tank through the delivery pump.
The raw material tank, the delivery pump and the spray head form a group of feeding and granulating systems, and the manufacturing equipment comprises at least two sets of feeding and granulating systems. For example, when producing cetostearyl alcohol, one set of cetostearyl alcohol is quantitatively conveyed to carry out cetostearyl alcohol granulation, and the other set of cetostearyl alcohol is quantitatively conveyed to carry out stearyl alcohol granulation, and the mixture of different proportions can be carried out by changing the flow of cetostearyl alcohol and the flow of stearyl alcohol.
The spray head structure comprises an upper cavity and a lower cavity, wherein the upper cavity is connected with the lower cavity through screws, a feeding hole is formed in the upper cavity, and a filter screen, a filler, a distribution pore plate and a discharge pore plate are sequentially stacked in the lower cavity.
The discharge pore plate is provided with a plurality of small holes with the aperture of 0.05-0.2mm, the distribution pore plate is also provided with a plurality of small holes with the aperture of 0.3-1.0mm, and the filter screen is a 100-500 mesh screen.
During operation of the inventive manufacturing apparatus, the temperature of the circulating air is maintained between 5 and 40 degrees.
After the technical scheme is adopted, the beneficial effects of the invention are as follows:
1. The product is a single-component solid mixture, the sphericity of small particles is high, the distribution is uniform, the diameter is 0.05-0.3mm, the product is not stuck and bonded, and the homogenization speed of small particle materials is high.
2. Because the cooling speed is extremely high, the crystal structure of the product particles is good, and the product is in a white crystal structure.
3. The formula of the materials in the production process is continuously adjustable, front ingredients are not needed, the safety of the production process is high, and the front separator of the fan is basically free of fine powder.
Drawings
FIG. 1 is a schematic diagram showing the connection of the apparatus according to embodiment 2 of the present invention;
fig. 2 is a schematic structural view of the spray head of the present invention.
In the figure, 1, a hexadecanol raw material tank; 2, a first conveying pump, 3, a first spray head, 4, an octadecyl alcohol raw material tank, 5, a second conveying pump, 6, a second spray head, 7, a cooling tower, 8, a discharge port, 9, a cooler, 10, a fan, 11, a separator, 31, a feed hole, 32, a discharge pore plate, 33, an upper cavity, 34, a lower cavity, 35, a screw, 36, a filter screen, 37, a filler, 38, a distribution pore plate, 39 and a sealing gasket.
Detailed Description
The invention will be further described with reference to the accompanying drawings.
Example 1
The manufacturing equipment of the pharmaceutical excipients is mainly used for preparing the pharmaceutical excipients such as stearic acid and cetostearyl alcohol, and comprises a material tank, a delivery pump, a cooling tower 7, a separator 11, a fan 10 and a cooler 9, wherein an air outlet at the top of the cooling tower 7 is connected with the fan 10 through the separator 11, the fan 10 is connected with an air inlet at the lower part of the cooling tower 7 through the cooler 9 to form air circulation, a discharge hole 8 is arranged at the bottom of the cooling tower, a spray head is arranged in the cooling tower 7 through a pipeline, and the spray head is connected with the material tank through the delivery pump.
The raw materials in the raw material tank are conveyed into a cooling tower 7 through a spray head and dispersed into liquid drops to fall downwards, cooling air is introduced from an air inlet at the lower part of the cooling tower 7 and is discharged from an air outlet at the top, and the liquid drops are conveyed into a fan 10 through a separator 11 to form a circulation. The dropped raw material liquid drops are in countercurrent contact with cold air to be immediately solidified into solid particles, the solid particles fall downwards, the solid particles continue to be cooled in the falling process, small particle products are screened and packaged at a bottom discharge hole 8 of a cooling tower 7, and a small amount of fine powder is brought into a separator 11 by the cold air to be separated.
The spray head structure in the manufacturing equipment comprises an upper cavity 33 and a lower cavity 34, wherein the upper cavity and the lower cavity are connected through a screw 35, a feeding hole 31 is formed in the upper cavity 33, and a filter screen 36, a filler 37, a distribution pore plate 38 and a discharge pore plate 32 are sequentially stacked in the lower cavity 34. The discharge orifice plate 32 is provided with a plurality of small holes with the aperture of 0.05-0.2mm, the distribution orifice plate 38 is also provided with a plurality of small holes with the aperture of 0.3-1.0mm, and the filter screen 36 is a 100-500 mesh screen.
Example 2
The equipment described in the example 1 is adopted to prepare the pharmaceutical auxiliary material cetostearyl alcohol small particles, and the specific following table 1 shows:
TABLE 1
Example 3
The apparatus described in example 1 was used to prepare small stearic acid particles as detailed in Table 1 below:
TABLE 2
Claims (3)
1. A manufacturing device of pharmaceutical excipients is characterized by comprising a raw material tank, a delivery pump, a cooling tower, a separator, a fan and a cooler, wherein an air outlet at the top of the cooling tower is connected with the fan through the separator, the fan is connected with an air inlet at the lower part of the cooling tower through the cooler to form air circulation, a discharge hole is formed in the bottom of the cooling tower, a spray head is installed in the cooling tower through a pipeline and is connected with the raw material tank through the delivery pump, the raw material tank, the delivery pump and the spray head form a group of feeding and granulating systems, the manufacturing device comprises at least two groups of feeding and granulating systems, the spray head structure comprises an upper cavity and a lower cavity, the upper cavity and the lower cavity are connected through screws, a feeding hole is formed in the upper cavity, and a filter screen, a filler, a distribution pore plate and a discharge pore plate are sequentially stacked in the lower cavity.
2. The device for manufacturing the pharmaceutical excipients according to claim 1 is characterized in that a plurality of small holes are arranged on the discharging pore plate, the aperture is 0.05-0.2mm, a plurality of small holes are also arranged on the distributing pore plate, the aperture is 0.3-1.0mm, and the filter screen is a 100-500 mesh screen.
3. The apparatus for producing a pharmaceutical excipient according to claim 1, wherein the circulating air temperature is maintained at 5 to 40 ℃.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110119029.1A CN112495301B (en) | 2021-01-28 | 2021-01-28 | A manufacturing device for pharmaceutical excipients |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110119029.1A CN112495301B (en) | 2021-01-28 | 2021-01-28 | A manufacturing device for pharmaceutical excipients |
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| Publication Number | Publication Date |
|---|---|
| CN112495301A CN112495301A (en) | 2021-03-16 |
| CN112495301B true CN112495301B (en) | 2025-03-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202110119029.1A Active CN112495301B (en) | 2021-01-28 | 2021-01-28 | A manufacturing device for pharmaceutical excipients |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105482156A (en) * | 2016-01-18 | 2016-04-13 | 佟立新 | Bead-shaped granular composite plastic additive, preparation method and application thereof |
| CN214382698U (en) * | 2021-01-28 | 2021-10-12 | 江苏优扬药业有限公司 | Manufacturing equipment for pharmaceutic adjuvant |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ525028A (en) * | 2000-08-31 | 2005-07-29 | Skyepharma Canada Inc | Milled particles |
| CN100579514C (en) * | 2001-07-06 | 2010-01-13 | 生命周期药物公司 | Method for preparing particulate matter by controlled agglomeration and method for increasing bioavailability |
| CN204147280U (en) * | 2013-07-11 | 2015-02-11 | 天士力制药集团股份有限公司 | Air cooling dripping pill production line |
| CN207079012U (en) * | 2017-05-09 | 2018-03-09 | 新疆兵团现代绿色氯碱化工工程研究中心(有限公司) | A kind of closed air-cooled type grain alkali process units |
| WO2019159988A1 (en) * | 2018-02-14 | 2019-08-22 | Ricoh Company, Ltd. | Method and apparatus for producing particles, particles, composition, particles dispersion liquid, and method for producing the particles dispersion liquid |
| CN212385779U (en) * | 2020-11-16 | 2021-01-22 | 上海芮澜工程科技有限公司 | Bisphenol A granulation system |
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2021
- 2021-01-28 CN CN202110119029.1A patent/CN112495301B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105482156A (en) * | 2016-01-18 | 2016-04-13 | 佟立新 | Bead-shaped granular composite plastic additive, preparation method and application thereof |
| CN214382698U (en) * | 2021-01-28 | 2021-10-12 | 江苏优扬药业有限公司 | Manufacturing equipment for pharmaceutic adjuvant |
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| Publication number | Publication date |
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| CN112495301A (en) | 2021-03-16 |
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