CN112495301A - Manufacturing equipment for pharmaceutic adjuvant - Google Patents
Manufacturing equipment for pharmaceutic adjuvant Download PDFInfo
- Publication number
- CN112495301A CN112495301A CN202110119029.1A CN202110119029A CN112495301A CN 112495301 A CN112495301 A CN 112495301A CN 202110119029 A CN202110119029 A CN 202110119029A CN 112495301 A CN112495301 A CN 112495301A
- Authority
- CN
- China
- Prior art keywords
- cooling tower
- fan
- pharmaceutic adjuvant
- raw material
- separator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000004519 manufacturing process Methods 0.000 title claims abstract description 23
- 239000000546 pharmaceutical excipient Substances 0.000 title claims abstract description 15
- 238000001816 cooling Methods 0.000 claims abstract description 29
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000007921 spray Substances 0.000 claims abstract description 13
- 239000002245 particle Substances 0.000 claims description 17
- 239000011148 porous material Substances 0.000 claims description 12
- 238000009826 distribution Methods 0.000 claims description 7
- 239000000945 filler Substances 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 abstract description 22
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 abstract description 12
- 235000021355 Stearic acid Nutrition 0.000 abstract description 10
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 abstract description 10
- 239000008117 stearic acid Substances 0.000 abstract description 10
- 239000000463 material Substances 0.000 abstract description 9
- 239000000843 powder Substances 0.000 abstract description 5
- 229940082500 cetostearyl alcohol Drugs 0.000 abstract description 4
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 abstract description 4
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 10
- 239000007787 solid Substances 0.000 description 3
- 239000013078 crystal Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000007710 freezing Methods 0.000 description 2
- 230000008014 freezing Effects 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011324 bead Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000004880 explosion Methods 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
- B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
- B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a manufacturing device of a pharmaceutic adjuvant, which is mainly used for preparing the pharmaceutic adjuvant of stearic acid and cetostearyl alcohol; comprises a raw material tank, a delivery pump, a cooling tower, a separator, a fan and a cooler; the air outlet at the top of the cooling tower is connected with a fan through a separator, and the fan is connected with the air inlet at the lower part of the cooling tower through a cooler to form air circulation; a discharge hole is formed in the bottom of the cooling tower; the cooling tower is internally provided with a spray head through a pipeline, and the spray head is connected with a raw material tank through a delivery pump. The material formula of the equipment product in the manufacturing process is continuously adjustable, and no pre-batching is needed; the production process is high in safety, and the separator before the fan basically has no fine powder.
Description
Technical Field
The invention relates to a manufacturing device of a pharmaceutic adjuvant, which is particularly suitable for preparing small granular stearic acid and cetostearyl alcohol.
Background
The medicinal small granular hexadecanol and octadecanol are easy to be mixed with other materials uniformly due to large specific surface area, and can be widely applied to the pharmaceutical industry. At present, the production process of the medicinal hexadecanol and octadecanol mainly comprises the steps of proportioning, melting and uniformly mixing the hexadecanol and the octadecanol according to a formula, and then cooling the mixture by a granulator to prepare products with shapes of beads, semi-spheres or sheets and the like. The process has four major disadvantages, firstly, the mixture of two different materials can reduce the freezing point, so that the product is easy to bond in summer, and is particularly remarkable for small granular products; secondly, in order to prevent the materials from being bonded, the particle size can be increased, but the particles are large and are not easy to solidify, or the particle cooling effect is poor, the product temperature is high, equipment needs to be added for deep cooling, and the large particles influence the use effect; thirdly, the material proportioning and mixing operation is complex; fourthly, the product has uneven size distribution, and more products containing fine powder are easy to cause safety problems and caking problems.
The medicinal stearic acid products have three types of stearic acid 50 (the stearic acid content is 40-60%), stearic acid 70 (the stearic acid content is 60-80%) and stearic acid 95, and at present, the stearic acid products are produced after being uniformly mixed in proportion. Various disadvantages also exist, first, freezing point depression; secondly, the materials are prepared in advance, and the products are easy to mix; thirdly, the fine powder of the product is unevenly bonded on the tower wall in a plurality of particles, so that the maintenance cost is high, and the safety problems of dust explosion and the like are easily caused.
Disclosure of Invention
The invention aims to provide manufacturing equipment of a pharmaceutic adjuvant, which aims at overcoming the defects of the existing manufacturing process and manufacturing equipment, is particularly suitable for preparing small granular stearic acid and hexadecanol and octadecanol to prepare a small granular product with high sphericity, the diameter of the product is 0.05-0.3mm, the product is not easy to melt and agglomerate in summer, the material proportion is automatic, and the continuous operation can be realized.
The technical scheme adopted by the invention is as follows:
the manufacturing equipment of the pharmaceutic adjuvant comprises a raw material tank, a delivery pump, a cooling tower, a separator, a fan and a cooler; the air outlet at the top of the cooling tower is connected with a fan through a separator, and the fan is connected with the air inlet at the lower part of the cooling tower through a cooler to form air circulation; a discharge hole is formed in the bottom of the cooling tower; the cooling tower is internally provided with a spray head through a pipeline, and the spray head is connected with a raw material tank through a delivery pump.
The raw material tank, the delivery pump and the spray head form a group of feeding and particle spraying systems, and the manufacturing equipment comprises at least two groups of feeding and particle spraying systems. For example, when hexadecanol and octadecanol are produced, hexadecanol granulation is carried out by conveying hexadecanol in a fixed quantity, octadecanol granulation is carried out by conveying octadecanol in a fixed quantity, and different proportions of combination can be carried out by changing the flow rate of the hexadecanol and the flow rate of the octadecanol.
The sprayer structure comprises an upper cavity and a lower cavity, and the upper cavity is connected with the lower cavity through screws; the upper cavity is provided with a feeding hole; the lower cavity is internally stacked with a filter screen, a filler, a distribution pore plate and a discharge pore plate in sequence.
A plurality of small holes are arranged on the discharge hole plate, and the aperture is 0.05-0.2 mm; a plurality of small holes are also arranged on the distribution pore plate, and the aperture is 0.3-1.0 mm; the filter screen is a 100-500-mesh screen.
The temperature of the circulating air is kept between 5 and 40 ℃ during the operation of the manufacturing equipment.
After the technical scheme is adopted, the invention has the beneficial effects that:
1. the product is a single-component solid mixture, small particles have high sphericity and uniform distribution, the diameter is 0.05-0.3mm, the product is not agglomerated and bonded, and the small particle material has high homogenization speed.
2. Because the cooling speed is extremely high, the crystal structure of the product particles is better, and the product is in a white crystal structure.
3. The material formula is continuously adjustable in the product manufacturing process, and no pre-batching is needed; the production process is high in safety, and the separator before the fan basically has no fine powder.
Drawings
FIG. 1 is a schematic diagram of the connection of an apparatus according to example 2 of the present invention;
fig. 2 is a schematic structural view of the head of the present invention.
In the figure: 1. a cetyl alcohol feed tank; 2. a first delivery pump; 3. a first spray nozzle; 4. a octadecanol raw material tank; 5. a second delivery pump; 6. a second spray head; 7. a cooling tower; 8. a discharge port; 9. a cooler; 10. a fan; 11. a separator; 31. a feed port; 32. a discharge orifice plate; 33. an upper cavity; 34. a lower cavity; 35. a screw; 36. a filter screen; 37. a filler; 38. distributing the pore plates; 39. a gasket seal.
Detailed Description
The invention will be further described with reference to the accompanying drawings.
Example 1
A manufacturing equipment of pharmaceutic adjuvant is mainly used for preparing pharmaceutic adjuvant stearic acid and cetostearyl alcohol; comprises a raw material tank, a delivery pump, a cooling tower 7, a separator 11, a fan 10 and a cooler 9; an air outlet at the top of the cooling tower 7 is connected with a fan 10 through a separator 11, and the fan 10 is connected with an air inlet at the lower part of the cooling tower 7 through a cooler 9 to form air circulation; a discharge hole 8 is formed in the bottom of the cooling tower; and a spray head is arranged in the cooling tower 7 through a pipeline, and the spray head is connected with the stock tank through a delivery pump.
The raw material in the raw material tank is conveyed into a cooling tower 7 through a spray head and dispersed into liquid drops which fall downwards; the cooling air is introduced from the lower air inlet of the cooling tower 7 and exhausted from the top air outlet, and forms a circulation in the fan 10 after passing through the separator 11. The dropped raw material liquid drops and the cold air are contacted in a countercurrent way and immediately solidified into solid particles, the solid particles fall down, the solid particles are continuously cooled in the falling process, small particle products are sieved and packaged at a discharge port 8 at the bottom of a cooling tower 7, and a small amount of fine powder is carried to a separator 11 by the cold air for separation.
The nozzle structure in the manufacturing equipment comprises an upper cavity 33 and a lower cavity 34, wherein the upper cavity and the lower cavity are connected through a screw 35; the upper cavity 33 is provided with a feeding hole 31; and a filter screen 36, a filler 37, a distribution pore plate 38 and a discharge pore plate 32 are sequentially stacked in the lower cavity 34. The discharge hole plate 32 is provided with a plurality of small holes with the aperture of 0.05-0.2 mm; the distribution pore plate 38 is also provided with a plurality of small pores with the pore diameter of 0.3-1.0 mm; the filter screen 36 is a 100-500 mesh screen.
Example 2
The equipment described in example 1 was used to prepare small granules of the pharmaceutical excipient cetostearyl alcohol: the details are shown in table 1 below:
TABLE 1
Example 3
Small stearic acid particles were prepared using the apparatus described in example 1: the details are shown in table 1 below:
TABLE 2
Claims (5)
1. The manufacturing equipment of the pharmaceutic adjuvant is characterized in that: comprises a raw material tank, a delivery pump, a cooling tower, a separator, a fan and a cooler; the air outlet at the top of the cooling tower is connected with a fan through a separator, and the fan is connected with the air inlet at the lower part of the cooling tower through a cooler to form air circulation; a discharge hole is formed in the bottom of the cooling tower; the cooling tower is internally provided with a spray head through a pipeline, and the spray head is connected with a raw material tank through a delivery pump.
2. A manufacturing apparatus of a pharmaceutic adjuvant according to claim 1, characterized in that: the raw material tank, the delivery pump and the spray head form a group of feeding and particle spraying systems, and the manufacturing equipment comprises at least two groups of feeding and particle spraying systems.
3. A manufacturing apparatus of a pharmaceutic adjuvant according to claim 1, characterized in that: the sprayer structure comprises an upper cavity and a lower cavity, and the upper cavity is connected with the lower cavity through screws; the upper cavity is provided with a feeding hole; the lower cavity is internally stacked with a filter screen, a filler, a distribution pore plate and a discharge pore plate in sequence.
4. A manufacturing apparatus of a pharmaceutic adjuvant according to claim 3, characterized in that: a plurality of small holes are arranged on the discharge hole plate, and the aperture is 0.05-0.2 mm; a plurality of small holes are also arranged on the distribution pore plate, and the aperture is 0.3-1.0 mm; the filter screen is a 100-500-mesh screen.
5. A manufacturing apparatus of a pharmaceutic adjuvant according to claim 1, characterized in that: the temperature of the circulating air is kept between 5 and 40 degrees.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110119029.1A CN112495301B (en) | 2021-01-28 | 2021-01-28 | A manufacturing device for pharmaceutical excipients |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110119029.1A CN112495301B (en) | 2021-01-28 | 2021-01-28 | A manufacturing device for pharmaceutical excipients |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN112495301A true CN112495301A (en) | 2021-03-16 |
| CN112495301B CN112495301B (en) | 2025-03-18 |
Family
ID=74953168
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110119029.1A Active CN112495301B (en) | 2021-01-28 | 2021-01-28 | A manufacturing device for pharmaceutical excipients |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN112495301B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002017883A2 (en) * | 2000-08-31 | 2002-03-07 | Rtp Pharma Inc. | Milled particles |
| WO2003004001A1 (en) * | 2001-07-06 | 2003-01-16 | Lifecycle Pharma A/S | Controlled agglomeration |
| CN104274320A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Dropping pill air cooling circulation device and dropping pill production line with air cooling circulation device |
| CN105482156A (en) * | 2016-01-18 | 2016-04-13 | 佟立新 | Bead-shaped granular composite plastic additive, preparation method and application thereof |
| CN207079012U (en) * | 2017-05-09 | 2018-03-09 | 新疆兵团现代绿色氯碱化工工程研究中心(有限公司) | A kind of closed air-cooled type grain alkali process units |
| WO2019159988A1 (en) * | 2018-02-14 | 2019-08-22 | Ricoh Company, Ltd. | Method and apparatus for producing particles, particles, composition, particles dispersion liquid, and method for producing the particles dispersion liquid |
| CN212385779U (en) * | 2020-11-16 | 2021-01-22 | 上海芮澜工程科技有限公司 | Bisphenol A granulation system |
| CN214382698U (en) * | 2021-01-28 | 2021-10-12 | 江苏优扬药业有限公司 | Manufacturing equipment for pharmaceutic adjuvant |
-
2021
- 2021-01-28 CN CN202110119029.1A patent/CN112495301B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002017883A2 (en) * | 2000-08-31 | 2002-03-07 | Rtp Pharma Inc. | Milled particles |
| WO2003004001A1 (en) * | 2001-07-06 | 2003-01-16 | Lifecycle Pharma A/S | Controlled agglomeration |
| CN104274320A (en) * | 2013-07-11 | 2015-01-14 | 天士力制药集团股份有限公司 | Dropping pill air cooling circulation device and dropping pill production line with air cooling circulation device |
| CN105482156A (en) * | 2016-01-18 | 2016-04-13 | 佟立新 | Bead-shaped granular composite plastic additive, preparation method and application thereof |
| CN207079012U (en) * | 2017-05-09 | 2018-03-09 | 新疆兵团现代绿色氯碱化工工程研究中心(有限公司) | A kind of closed air-cooled type grain alkali process units |
| WO2019159988A1 (en) * | 2018-02-14 | 2019-08-22 | Ricoh Company, Ltd. | Method and apparatus for producing particles, particles, composition, particles dispersion liquid, and method for producing the particles dispersion liquid |
| CN212385779U (en) * | 2020-11-16 | 2021-01-22 | 上海芮澜工程科技有限公司 | Bisphenol A granulation system |
| CN214382698U (en) * | 2021-01-28 | 2021-10-12 | 江苏优扬药业有限公司 | Manufacturing equipment for pharmaceutic adjuvant |
Non-Patent Citations (2)
| Title |
|---|
| 曾亚森;罗宇玲: "中药喷雾干燥防止粘壁技术的研究", 医药工程设计, no. 003, 31 December 2006 (2006-12-31), pages 10 - 13 * |
| 汪华林, 吕天宝: "喷浆造粒干燥机的改造", 设备管理与维修, no. 02, 2 January 1994 (1994-01-02), pages 16 - 17 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN112495301B (en) | 2025-03-18 |
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