CN112472877B - Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter - Google Patents
Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter Download PDFInfo
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- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000001050 lubricating effect Effects 0.000 title claims abstract description 11
- 229920000642 polymer Polymers 0.000 claims abstract description 29
- 239000002243 precursor Substances 0.000 claims abstract description 19
- 239000010687 lubricating oil Substances 0.000 claims abstract description 17
- 230000010412 perfusion Effects 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 7
- 238000001802 infusion Methods 0.000 claims abstract description 3
- 238000001723 curing Methods 0.000 claims description 25
- 239000007788 liquid Substances 0.000 claims description 24
- 229920002319 Poly(methyl acrylate) Polymers 0.000 claims description 10
- 229920001485 poly(butyl acrylate) polymer Polymers 0.000 claims description 10
- GTELLNMUWNJXMQ-UHFFFAOYSA-N 2-ethyl-2-(hydroxymethyl)propane-1,3-diol;prop-2-enoic acid Chemical class OC(=O)C=C.OC(=O)C=C.OC(=O)C=C.CCC(CO)(CO)CO GTELLNMUWNJXMQ-UHFFFAOYSA-N 0.000 claims description 8
- 239000000314 lubricant Substances 0.000 claims description 8
- 239000003921 oil Substances 0.000 claims description 7
- 239000004814 polyurethane Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- 239000004698 Polyethylene Substances 0.000 claims description 6
- -1 polyethylene Polymers 0.000 claims description 6
- 229920000573 polyethylene Polymers 0.000 claims description 6
- 238000001029 thermal curing Methods 0.000 claims description 6
- 238000005406 washing Methods 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000004372 Polyvinyl alcohol Substances 0.000 claims description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 4
- 239000002608 ionic liquid Substances 0.000 claims description 3
- 239000002480 mineral oil Substances 0.000 claims description 3
- 235000010446 mineral oil Nutrition 0.000 claims description 3
- 239000012188 paraffin wax Substances 0.000 claims description 3
- 239000010702 perfluoropolyether Substances 0.000 claims description 3
- 238000000935 solvent evaporation Methods 0.000 claims description 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 229920002635 polyurethane Polymers 0.000 claims 2
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims 1
- 238000002360 preparation method Methods 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 4
- 239000012530 fluid Substances 0.000 abstract description 2
- 241000894006 Bacteria Species 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000010586 diagram Methods 0.000 description 5
- 238000000016 photochemical curing Methods 0.000 description 4
- 238000009736 wetting Methods 0.000 description 3
- XMLYCEVDHLAQEL-UHFFFAOYSA-N 2-hydroxy-2-methyl-1-phenylpropan-1-one Chemical compound CC(C)(O)C(=O)C1=CC=CC=C1 XMLYCEVDHLAQEL-UHFFFAOYSA-N 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 230000000379 polymerizing effect Effects 0.000 description 2
- 238000002791 soaking Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000001631 haemodialysis Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000000322 hemodialysis Effects 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012876 topography Methods 0.000 description 1
- 238000002834 transmittance Methods 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Materials For Medical Uses (AREA)
Abstract
本发明提供一种用于医疗导管的润滑油灌注的超滑多孔表面的制备方法，该方法基于快速搅拌法得到含有大量不相溶液滴的聚合物前聚体溶液，随后将该溶液导入管道模具中，固化后洗去未聚合的部分即得到具有多孔结构的导管，之后用润滑液浸润其孔洞结构及其表面得到用于医疗导管的润滑油灌注的超滑多孔表面。本发明所制备导管表面有化学惰性的润滑油覆盖，具有一定的自修复性能，能够长期有效地防止细菌、蛋白等生物成分的黏附。本发明制备方法简单快捷，稳定性强，寿命长，而且制备出的功能性表面适用于医疗导管和手术器械等，对于拓宽浸润性材料的生物医学价值具有重要意义。The present invention provides a method for preparing an ultra-smooth porous surface for lubricating oil infusion of medical catheters. The method is based on a rapid stirring method to obtain a polymer precursor solution containing a large number of droplets of an inphase solution, and then the solution is introduced into a pipeline mold. After curing, wash off the unpolymerized part to obtain a catheter with a porous structure, and then infiltrate its pore structure and its surface with lubricating fluid to obtain an ultra-smooth porous surface for lubricating oil perfusion of medical catheters. The surface of the catheter prepared by the invention is covered with chemically inert lubricating oil, has a certain self-repair performance, and can effectively prevent the adhesion of biological components such as bacteria and proteins for a long time. The preparation method of the invention is simple and quick, has strong stability and long service life, and the prepared functional surface is suitable for medical catheters and surgical instruments, etc., and is of great significance for broadening the biomedical value of the infiltrating material.
Description
Technical Field
The invention belongs to the technical field of biological materials, and particularly relates to a preparation method of a super-smooth porous surface for lubricating oil perfusion of a medical catheter, which can be applied to the technical fields of transfusion, dialysis, catheterization and the like.
Background
Medical catheters, such as urinary catheters, hemodialysis catheters, venous catheters, drainage tubes, etc., are indispensable components of medical devices, which usually require direct contact with living organisms or physiological fluids. Once a medical catheter becomes contaminated or clogged, the patient is at a serious risk of infection and even life threatening. Therefore, there is a need to develop new catheter materials with good biocompatibility, anticoagulant, antibacterial and anti-adhesion capabilities.
The development of interface science has injected new viability into the development of medical catheters. Researchers have prepared many medical catheters with super-wetting properties, such as super-hydrophobicity, by modifying the surface topography and chemical composition of medical catheters by physical or chemical means. However, these medical catheters are susceptible to deterioration of their super-wetting properties and short service lives. The lubricating liquid-filled ultra-smooth porous surface becomes an ideal material for constructing the medical catheter due to the excellent liquid repellency, certain self-repairing performance, good light transmittance and the like.
Therefore, the invention provides a preparation method of the lubricating oil-filled super-smooth porous surface for the medical catheter, which can be used for infusion, catheterization and the like and has good stability and self-repairing performance.
Disclosure of Invention
The invention aims to provide a preparation method of a super-smooth porous surface for lubricating oil perfusion of a medical catheter, aiming at the defects that the liquid repellency, the anti-biological adhesion performance and the like of the surface of the traditional wetting catheter are easy to damage.
The invention adopts the following technical scheme:
a method of preparing a lubricant infused ultra-smooth porous surface for a medical catheter comprising the steps of:
s1, taking a polymer precursor, preparing a polymer precursor solution, adding a liquid which is immiscible with the polymer precursor solution and can not be polymerized into the polymer precursor solution, and quickly stirring to form a precursor solution dispersed with a large number of liquid drops;
s2, pouring the solution prepared in the S1 into a catheter mould, carrying out solidification polymerization, and then fully washing unpolymerized liquid drops by water and alcohol to obtain a catheter with a hole structure;
and S3, infiltrating a layer of chemically inert lubricating oil into the inside and the surface of the hole of the catheter prepared in the step S2 to obtain the super-smooth porous surface for lubricating oil perfusion of the medical catheter.
Further, in S1, the polymer prepolymer is one of ethoxylated trimethylolpropane triacrylate (ETPTA), Polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA), and polylactic-co-glycolic acid (PLGA).
Further, in S1, the curing method is uv curing, photo curing, thermal curing, or solvent evaporation curing.
Further, in S1, the liquid immiscible with the polymer prepolymer solution and incapable of polymerization is one of F108, polyvinyl alcohol (PVA), and Sodium Dodecyl Sulfate (SDS).
Further, in S1, when the polymer prepolymer is ethoxylated trimethylolpropane triacrylate (ETPTA), the curing mode is uv curing; when the polymer precursor is polymethyl acrylate (PMA) or polybutyl acrylate (PBA), the curing mode is photocuring or thermocuring; when the polymer prepolymer is Polyurethane (PU), polyethylene or polylactic-co-glycolic acid (PLGA), the curing mode is solvent volatilization curing.
Further, the inner hole structures of the conduits prepared in the step S2 are communicated with each other, so that a certain amount of lubricating liquid can be stored.
Further, in S3, the lubricant is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil, and ionic liquid.
The invention also provides a lubricating oil-infused ultra-smooth porous surface for a medical catheter, which is prepared according to the preparation method.
The invention has the beneficial effects that:
(1) the super-smooth porous surface infused with the lubricating liquid provided by the invention has good stability, can reduce the adhesion of water molecules and biomolecules in the use process, prevent the formation of thrombus, bacterial film and the like, prolong the service life of the medical catheter and reduce the risk of infection in the use process;
(2) the medical catheter is prepared by adopting a rapid stirring method, is simple, convenient and rapid to operate, has low cost, is suitable for mass production, and greatly expands the practical value of the infiltrating material;
(3) the super-smooth porous surface filled with the lubricating liquid provided by the invention is suitable for various medical instruments such as scalpels and cardiac pacemakers, and shows good applicability and market value.
Drawings
FIG. 1 is a schematic view of a lubricant-infused ultra-smooth porous surface for medical catheters and a process for preparing the same according to the present invention; wherein, the diagram A is a schematic diagram of a polymer prepolymer solution dispersed with a large number of liquid drops obtained by a rapid stirring method, and the diagram B is a schematic diagram of a polymer prepolymer solution poured into a catheter mould and polymerized; FIG. C is a schematic view of a porous catheter obtained by washing away unpolymerized solution;
FIG. 2 is a schematic diagram showing a sliding process of 10. mu.l water drops on the ultra-smooth porous surface prepared in example 3 of the present invention.
The specific implementation mode is as follows:
in order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention and the accompanying drawings, and it is obvious that the described embodiments are some embodiments of the present invention, but not all embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. The conditions not specified in the examples are generally those in routine experiments.
A method of preparing a lubricant infused ultra-smooth porous surface for a medical catheter comprising the steps of:
s1, taking a polymer precursor, preparing a polymer precursor solution, adding a liquid (F108, polyvinyl alcohol or sodium dodecyl sulfate) which is immiscible with the polymer precursor solution and can not be polymerized into the polymer precursor solution, and rapidly stirring to form a precursor solution dispersed with a large number of liquid drops, as shown in figure 1A; the polymer prepolymer is one of ethoxylated trimethylolpropane triacrylate (ETPTA), Polyurethane (PU), polyethylene, polymethyl acrylate (PMA), polybutyl acrylate (PBA) and polylactic-co-glycolic acid (PLGA); the curing mode is ultraviolet curing, photocuring, thermocuring or solvent volatilization curing;
specifically, when the polymer prepolymer adopts ethoxylated trimethylolpropane triacrylate (ETPTA), the curing mode is ultraviolet curing; when the polymer precursor is polymethyl acrylate (PMA) or polybutyl acrylate (PBA), the curing mode is photocuring or thermocuring; when the polymer prepolymer is Polyurethane (PU), polyethylene or polylactic-co-glycolic acid (PLGA), the curing mode is solvent volatilization curing.
S2, pouring the solution prepared in the S1 into a catheter mould, solidifying the solution, as shown in figure 1B, and then washing off unpolymerized liquid drops by water and alcohol fully to obtain a catheter with a hole structure, as shown in figure 1C; the hole structures in the guide pipe are communicated with each other, and a certain amount of lubricating liquid can be stored.
S3, infiltrating a layer of chemically inert lubricating oil into the inside and the surface of the catheter hole prepared in the step S2 to obtain a super-smooth porous surface for lubricating oil perfusion of the medical catheter; the lubricating oil is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil and ionic liquid.
Example 1
Preparation of hard lubricant infused ultra-smooth porous catheter:
(1) a solution of ethoxylated trimethylolpropane triacrylate (ETPTA) containing 1% (v/v) photoinitiator (2-hydroxy-2-methylpropiophenone) was prepared in a centrifuge tube, followed by addition of a 2% (w/v) F108 solution, which was rapidly stirred to form a prepolymer solution with a large number of droplets dispersed therein.
(2) And pouring the formed prepolymer solution dispersed with a large number of liquid drops into a catheter mould, polymerizing by using 365 nm-waveband ultraviolet light, and then fully washing off the unpolymerized liquid drops by using water and alcohol to obtain the pipeline with the hole structure.
(3) And soaking the prepared pipeline in a fluorosilicone oil solution to soak a layer of fluorosilicone oil in the hole and on the surface of the hole to obtain the super-smooth surface for the lubricating oil perfusion of the medical catheter.
Example 2
Preparing a flexible lubricating oil-filled ultra-smooth porous catheter:
(1) a20% (w/v) Polyurethane (PU) solution was prepared in a centrifuge tube, followed by addition of a liquid paraffin solution and rapid stirring of the solution to form a prepolymer solution in which a large number of droplets were dispersed.
(2) And pouring the formed prepolymer solution dispersed with a large number of liquid drops into a catheter mould, and putting the catheter mould on a 60 ℃ hot bench for heating to volatilize the solvent so as to obtain the lubricating oil-filled super-smooth surface for the medical catheter.
Example 3
Wettability testing of lubricating oil-impregnated ultra-smooth porous catheters:
(1) a solution of ethoxylated trimethylolpropane triacrylate (ETPTA) containing 1% (v/v) photoinitiator (2-hydroxy-2-methylpropiophenone) was prepared in a centrifuge tube, followed by addition of a solution containing 2% (w/v) F108, and the solution was rapidly stirred to form a prepolymer solution with a large number of droplets dispersed therein.
(2) Pouring the precursor solution dispersed with a large number of liquid drops into a catheter mould, polymerizing by using 365 nm-waveband ultraviolet light, and then fully washing off the unpolymerized liquid drops by using water and alcohol to obtain the pipeline with the hole structure.
(3) And soaking the prepared pipeline in a fluorosilicone oil solution to soak a layer of fluorosilicone oil in the hole and on the surface of the hole to obtain the super-smooth surface for the lubricating oil perfusion of the medical catheter.
(4) A10. mu.l drop was dropped on the surface of the prepared medical catheter and gently tilted, and the angle at which the drop started to slide (i.e., the sliding angle) was recorded, showing that the sliding angle was less than 5 °, as shown in FIG. 2.
The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments, and all technical solutions belonging to the idea of the present invention belong to the protection scope of the present invention, it should be noted that, for those skilled in the art, several modifications and decorations without departing from the principle of the present invention should be regarded as the protection scope of the present invention.
Claims (8)
1. A method of preparing a lubricant infused ultra-smooth porous surface for a medical catheter, comprising the steps of:
s1, taking a polymer precursor, preparing a polymer precursor solution, adding a liquid which is immiscible with the polymer precursor solution and can not be polymerized into the polymer precursor solution, and quickly stirring to form a precursor solution dispersed with a large number of liquid drops;
s2, pouring the solution prepared in the S1 into a catheter mould, solidifying, and then fully washing off unpolymerized liquid drops by water and alcohol to obtain the catheter with a hole structure;
and S3, infiltrating a layer of chemically inert lubricating oil into the inside and the surface of the hole of the catheter prepared in the step S2 to obtain the super-smooth porous surface for lubricating oil perfusion of the medical catheter.
2. The method of claim 1, wherein in S1, the polymer prepolymer is one of ethoxylated trimethylolpropane triacrylate, polyurethane, polyethylene, polymethyl acrylate, polybutyl acrylate, and polylactic acid-glycolic acid copolymer.
3. The method for preparing a lubricant-infused ultra-smooth porous surface for medical catheters as claimed in claim 1, wherein in S2, the curing method is uv curing, thermal curing or solvent evaporation curing.
4. The method of claim 1, wherein the non-polymerizable liquid immiscible with the polymer prepolymer solution in S1 is one of F108, polyvinyl alcohol, and sodium lauryl sulfate.
5. The method for preparing a lubricating oil-infused ultra-smooth porous surface for medical catheters as claimed in claim 1, wherein in S2, when the polymer prepolymer is ethoxylated trimethylolpropane triacrylate, the curing method is uv curing; when the polymer prepolymer is polymethyl acrylate or polybutyl acrylate, the curing mode is ultraviolet curing or thermocuring; when the polymer prepolymer is polyurethane, polyethylene or polylactic acid-glycolic acid copolymer, the curing mode is solvent volatilization curing.
6. The method of claim 1, wherein the holes inside the catheter prepared in step S2 are interconnected to store a certain amount of lubricant.
7. The method of claim 1, wherein in S3, the lubricant is one of perfluoropolyether, paraffin, fluorosilicone oil, mineral oil, and ionic liquid.
8. A super-smooth porous surface for lubricant infusion of medical catheters, prepared according to the method of any one of claims 1 to 7.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202011509397.9A CN112472877B (en) | 2020-12-18 | 2020-12-18 | Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter |
| PCT/CN2021/135647 WO2022127631A1 (en) | 2020-12-18 | 2021-12-06 | Preparation method for ultra-smooth porous surface for lubricating oil infusion of medical catheter |
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| CN202011509397.9A CN112472877B (en) | 2020-12-18 | 2020-12-18 | Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter |
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| CN112472877B true CN112472877B (en) | 2022-03-08 |
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| CN112472877B (en) * | 2020-12-18 | 2022-03-08 | 南京鼓楼医院 | Method for preparing lubricating oil-infused ultra-smooth porous surface for medical catheter |
| CN113616859A (en) * | 2021-07-08 | 2021-11-09 | 深圳先进技术研究院 | Antibacterial lubricating coating and preparation method and application thereof |
| CN113528010A (en) * | 2021-08-27 | 2021-10-22 | 电子科技大学 | Preparation and application of super-smooth coating with long-acting ice-thinning characteristic |
| CN117925064B (en) * | 2024-01-23 | 2025-10-03 | 江苏大学 | A method and application of underwater perfusion of lubricating oil to construct a stable Nepenthes-like super-slip surface |
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| WO2022127631A1 (en) | 2022-06-23 |
| CN112472877A (en) | 2021-03-12 |
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