CN112370491A - Traditional Chinese medicine composition for conditioning yang-deficiency constitution, traditional Chinese medicine preparation containing same and application - Google Patents
Traditional Chinese medicine composition for conditioning yang-deficiency constitution, traditional Chinese medicine preparation containing same and application Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for conditioning yang-deficiency constitution, a traditional Chinese medicine preparation containing the same and application thereof, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20-60 parts of lucid ganoderma, 20-60 parts of longan pulp, 5-20 parts of eucommia bark, 5-20 parts of cistanche and 1-5 parts of cinnamon. The traditional Chinese medicine formula provided by the invention adopts reasonably matched functional food with homology of medicine and food, has the effects of warming kidney and tonifying spleen, warming yang and dispelling cold, is used for eliminating viscera channels and collaterals cold evil, warming middle-jiao and dispelling cold, tonifying qi and strengthening spleen, conditioning yang deficiency constitution, and can be used for remarkably improving yang deficiency constitution symptoms and physical signs.
Description
Technical Field
The invention relates to a medicinal and edible health-care product, in particular to a traditional Chinese medicine composition capable of conditioning yang-deficiency constitution, a traditional Chinese medicine preparation containing the same and application thereof.
Background
The Chinese medical science college classifies the constitutions of human bodies into mild constitutions, qi deficiency constitutions, yang deficiency constitutions, yin deficiency constitutions, phlegm-damp constitutions, damp-heat constitutions, blood stasis constitutions, qi stagnation constitutions and specific constitutions in the "classification and determination standards of Chinese medical science constitutions". The constitution of yang deficiency refers to the pathological phenomena of yang deficiency, hypofunction or asthenia, hypometabolism, low reactivity of organism and insufficiency of yang heat. Yang-qi can warm the limbs and viscera, and if yang is deficient, the body functions will decline, which is likely to cause symptoms of deficiency-cold. The common symptoms include stomach yang deficiency, spleen yang deficiency, kidney yang deficiency, etc. Su Wen & Tiaojing treatise records that "yang deficiency causes external cold", which means qi deficiency or decline of fire from gate of life, and qi and gate of life both belong to yang, so the name is that lung governs qi, qi deficiency usually belongs to lung qi deficiency or middle qi deficiency, so defensive exterior is insecurity, so external cold is caused; yang deficiency leading to yin excess, and yang deficiency also seen in heart yang deficiency or spleen yang deficiency, manifested as white complexion, cold hands and feet, aversion to cold, easy sweating, thin stools, clear and long urine, light lips, tastelessness, poor appetite, pale tongue, white and moist coating, weak pulse, etc. However, products for conditioning yang-deficiency constitution are currently available.
Disclosure of Invention
Aiming at the defects in the prior art, the invention provides a traditional Chinese medicine composition for conditioning yang-deficiency constitution and a preparation method thereof.
A traditional Chinese medicine composition for conditioning yang-deficiency constitution comprises the following components in parts by weight: the traditional Chinese medicine composition comprises the following components in parts by weight: 20-60 parts of lucid ganoderma, 20-60 parts of longan pulp, 5-20 parts of eucommia bark, 5-20 parts of cistanche and 1-5 parts of cinnamon.
Preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 20-40 parts of lucid ganoderma, 20-40 parts of longan pulp, 5-15 parts of eucommia bark, 5-15 parts of cistanche and 1-3 parts of cinnamon.
Further preferably, the traditional Chinese medicine composition comprises the following components in parts by weight: 30 parts of lucid ganoderma, 30 parts of longan pulp, 10 parts of eucommia bark, 10 parts of cistanche and 2 parts of cinnamon.
The invention also provides application of the traditional Chinese medicine composition in preparing medicines and health-care products for conditioning yang-deficiency constitution.
The invention also provides a traditional Chinese medicine preparation which is prepared by adding auxiliary materials into the traditional Chinese medicine composition for conditioning yang-deficiency constitution. Specifically, the traditional Chinese medicine preparation can be powder, granules, powder, capsules, tablets, pills or syrup.
The invention also provides a preparation method of the traditional Chinese medicine preparation, which comprises the following steps:
weighing lucid ganoderma, longan pulp, eucommia ulmoides, cistanche deserticola and cinnamon according to a ratio, crushing the cinnamon, mixing, adding 9-12 times of water, condensing, refluxing and extracting for 2-3 times by boiling water, decocting for 1-2h, controlling the temperature of an aqueous solution to be 95-100 ℃, and combining the extract;
step two, filtering the leaching liquor, and concentrating the filtrate at 40-80 ℃ until the specific gravity is 1.00-1.14 to obtain a concentrate;
and step three, feeding the concentrated solution into a spray dryer for drying to obtain an extract, crushing the extract and auxiliary materials, sieving the extract with a 100-mesh sieve, fully mixing the extract and the auxiliary materials, preparing a soft material by using 60-70% ethanol, extruding the soft material, sieving the soft material with a 14-mesh sieve for granulation, and drying to obtain granules.
In some embodiments of the invention, the excipients include diluents, thickeners, sweeteners, and citric acid.
In some embodiments of the invention, the diluent comprises dextrin and lactose, and the weight ratio of dextrin, lactose, extract is 1: 1-2: 1-2.
The traditional Chinese medicines for conditioning yang-deficiency constitution selected by the invention are all medicinal and edible components, wherein:
ganoderma lucidum: warm in nature and bland in taste. It enters heart, lung, liver and kidney meridians. Tonify qi and induce tranquilization, relieve cough and dyspnea. Can be used for treating vertigo, insomnia, palpitation, short breath, and cough and asthma due to asthenia.
Longan pulp: sweet in nature and warm in nature. It enters heart, kidney, liver and spleen meridians. Tonify heart and spleen, replenish qi and blood, and induce tranquilization. Can be used for treating palpitation due to deficiency of both heart and spleen and deficiency of qi and blood.
Eucommia ulmoides: sweet and warm. It enters liver and kidney meridians. Tonify liver and kidney, strengthen tendons and bones, prevent abortion. Can be used for treating lumbago due to kidney deficiency, weakness of bones and muscles, and pregnant bleeding and threatened abortion; hypertension is caused.
Cistanche deserticola: warm in nature, sweet and salty in taste. It enters kidney and large intestine meridians. Used for tonifying kidney yang; replenishing essence and blood; moistening intestinal tract. Deficiency of both the major and kidney yang; impotence due to deficiency of essence and blood; spermatorrhea; white turbidity; frequent micturition and dribbling; lumbago and weak feet; tinnitus and blurred vision; menstrual period of menstruation; infertility due to cold uterus; constipation due to intestinal dryness.
Cinnamon: pungent and sweet in flavor and strongly hot in nature. Entering kidney, spleen, heart and liver meridians; tonify fire and strengthen yang, guide fire to the origin, dispel cold and alleviate pain, activate blood and dredge channels. Can be used for treating sexual impotence, cold womb, psychroalgia of heart and abdomen, vomiting and diarrhea due to deficiency cold, amenorrhea, dysmenorrhea, and warming channels.
The invention has the beneficial effects that:
the traditional Chinese medicine composition disclosed by the invention adopts medicinal and edible functional medicinal materials, and a conditioning method for warming the interior, tonifying qi and nourishing yang is determined through reasonable collocation so as to eliminate internal and collateral cold evil of viscera, warm the middle and dispel cold, tonify qi and invigorate spleen, and can obviously improve yang deficiency constitutional symptoms and physical signs through conditioning so as to enable the yang deficiency constitutional symptoms and physical signs to be converted to mild natures.
Detailed Description
Hereinafter, embodiments of the present invention will be described in detail. The following examples are only for illustrating the technical solutions of the present invention more clearly, and therefore are only examples, and the protection scope of the present invention is not limited thereby.
It is to be noted that, unless otherwise specified, technical or scientific terms used herein shall have the ordinary meaning as understood by those skilled in the art to which the invention pertains.
Example 1
The embodiment provides a traditional Chinese medicine composition for conditioning yang-deficiency constitution, which comprises the following components in parts by weight: 30 parts of lucid ganoderma, 30 parts of longan pulp, 10 parts of eucommia bark, 10 parts of cistanche and 2 parts of cinnamon.
The Chinese medicinal composition is prepared into a granular Chinese medicinal preparation according to the following method:
step one, weighing lucid ganoderma, longan pulp, eucommia ulmoides, cistanche and cinnamon according to a ratio, mixing, adding water 9 times of the mixture, condensing, refluxing and extracting for 3 times by boiling water, decocting for 1h, controlling the temperature of an aqueous solution to be 100 ℃, and combining the boiling water condensing, refluxing and extracting liquor;
step two, filtering boiling water, condensing and refluxing the leaching liquor, and concentrating the filtrate at the temperature of 60 ℃ until the specific gravity is 1.05 to obtain a concentrate;
and step three, feeding the concentrate into a spray dryer for drying to obtain an extract, crushing the extract and auxiliary materials, sieving the crushed extract with a 100-mesh sieve, fully mixing the crushed extract and the auxiliary materials, preparing a soft material by using 70% ethanol, extruding the soft material, sieving the soft material with a 14-mesh sieve, granulating the soft material, and drying the soft material to obtain granules.
In the preparation method, the auxiliary materials comprise a diluent, a thickening agent, a sweetening agent and citric acid. Specifically, the diluent is dextrin and lactose, and the mass ratio of the dextrin to the lactose to the extract is 1:1: 2. The thickening agent added in each agent is 0.2g of xanthan gum, 0.025g of sweetener aspartame and 0.1g of citric acid.
Further, the inlet temperature was 110 ℃ and the outlet temperature was 50 ℃ during spray drying.
Further, mixing the extract with adjuvants, feeding into a granulator, adjusting the rotation speed of a peristaltic pump to spray slurry when the temperature of inlet air rises to 70 deg.C, sieving with 18 mesh vibrating screen, oven drying at 65 deg.C, sieving with 14 mesh sieve, grading, and packaging into 10 g/bag.
Example 2
The embodiment provides a traditional Chinese medicine composition for conditioning yang-deficiency constitution, which comprises the following components in parts by weight: 40 parts of lucid ganoderma, 40 parts of longan pulp, 15 parts of eucommia bark, 15 parts of cistanche and 3 parts of cinnamon.
The Chinese medicinal composition is prepared into a granular Chinese medicinal preparation according to the following method:
step one, weighing lucid ganoderma, longan pulp, eucommia ulmoides, cistanche and cinnamon according to a ratio, mixing, adding water in an amount which is 12 times that of the mixture, condensing, refluxing and leaching for 3 times by boiling water, decocting for 1.5 hours, controlling the temperature of the water solution to be 100 ℃, and combining the boiling water condensing, refluxing and leaching liquor;
step two, filtering boiling water, condensing and refluxing the leaching liquor, and concentrating the filtrate at 60 ℃ until the specific gravity is 1.14 to obtain a concentrate;
and step three, feeding the concentrate into a spray dryer for drying to obtain an extract, crushing the extract and auxiliary materials, sieving the crushed extract with a 100-mesh sieve, fully mixing the crushed extract and the auxiliary materials, preparing a soft material by using 60% ethanol, extruding the soft material, sieving the soft material with a 14-mesh sieve, granulating the soft material, and drying the soft material to obtain granules.
In the preparation method, the auxiliary materials comprise a diluent, a thickening agent, a sweetening agent and citric acid. Specifically, the diluent is dextrin and lactose, and the mass ratio of the dextrin to the lactose to the extract is 1:2: 2. The thickening agent added in each agent is 0.2g of xanthan gum, 0.025g of sweetener aspartame and 0.1g of citric acid.
Further, the inlet temperature was 110 ℃ and the outlet temperature was 50 ℃ during spray drying.
Further, mixing the extract with adjuvants, feeding into a granulator, adjusting the rotation speed of a peristaltic pump to spray slurry when the temperature of inlet air rises to 70 deg.C, sieving with 18 mesh vibrating screen, oven drying at 65 deg.C, sieving with 14 mesh sieve, grading, and packaging into 10 g/bag.
Example 3
The embodiment provides a traditional Chinese medicine composition for conditioning yang-deficiency constitution, which comprises the following components in parts by weight: 20 parts of lucid ganoderma, 20 parts of longan pulp, 5 parts of eucommia bark, 5 parts of cistanche and 1 part of cinnamon.
The Chinese medicinal composition is prepared into a granular Chinese medicinal preparation according to the following method:
step one, weighing lucid ganoderma, longan pulp, eucommia ulmoides, cistanche and cinnamon according to a ratio, mixing, adding water in an amount which is 10 times that of the mixture, condensing, refluxing and leaching in boiling water for 3 times, decocting for 2 hours, controlling the temperature of an aqueous solution to be 100 ℃, and combining the boiling water condensing, refluxing and leaching liquor;
step two, filtering boiling water, condensing and refluxing the leaching liquor, and concentrating the filtrate at the temperature of 60 ℃ until the specific gravity is 1.05 to obtain a concentrate;
and step three, feeding the concentrate into a spray dryer for drying to obtain an extract, crushing the extract and auxiliary materials, sieving the crushed extract with a 100-mesh sieve, fully mixing the crushed extract and the auxiliary materials, preparing a soft material by using 70% ethanol, extruding the soft material, sieving the soft material with a 14-mesh sieve, granulating the soft material, and drying the soft material to obtain granules.
In the preparation method, the auxiliary materials comprise a diluent, a thickening agent, a sweetening agent and citric acid. Specifically, the diluent is dextrin and lactose, and the mass ratio of the dextrin to the lactose to the extract is 1:1: 2. The thickening agent added in each agent is 0.2g of xanthan gum, 0.025g of sweetener aspartame and 0.1g of citric acid.
Further, the inlet temperature was 110 ℃ and the outlet temperature was 50 ℃ during spray drying.
Further, mixing the extract with adjuvants, feeding into a granulator, adjusting the rotation speed of a peristaltic pump to spray slurry when the temperature of inlet air rises to 70 deg.C, sieving with 18 mesh vibrating screen, oven drying at 65 deg.C, sieving with 14 mesh sieve, grading, and packaging into 10 g/bag.
The granules prepared in examples 1 to 3 of the present invention were subjected to quality inspection of granules according to quality inspection items of granules specified in pharmacopoeia of the people's republic of china (2010 edition), including particle size, hygroscopicity and solubility of granules. The examination shows that the granular preparation prepared by the embodiment of the invention is stable, can fully retain the active ingredients of the traditional Chinese medicine, and can meet the requirements of good taste, good forming, small hygroscopicity and quick dissolution.
The taking method comprises the following steps: the medicine is taken once every morning and evening after meals, and one bag is taken each time. It is administered orally with water.
Analysis of efficacy
For 54 patients with yang-deficiency constitution, the identification of yang-deficiency constitution refers to "classification and judgment of traditional Chinese medicine constitution" published by the traditional Chinese medicine society of traditional Chinese medicine, 4-month-9-Rihua, 2009. The test group and the control group were randomly divided, and 27 cases were added to each group. Test groups: 13 men and 14 women, the ages of which are 20-55 years, and the average age is 43.79 years. Control group: 15 men and 12 women with age between 22-60 years, and average age of 45 years.
The intervention method comprises the following steps: the experimental group took the granular formulation prepared in example 1 once in the morning and evening, 1 bag each time, and the control group took the same packaged granules without the traditional Chinese medicine formula, and both groups took 3 months.
The statistical method comprises the following steps: analysis was performed using SPSS software and the measurements were expressed as (x. + -. s).
The curative effect standard is as follows: the statistical results obtained before and after the internal intervention on the yang-deficiency constitution transformation are shown in the following table according to the Chinese medicine constitution Classification and judgment standards issued by the Chinese medical society.
TABLE 1 comparative grading of transformation of constitutions of yang deficiency
| Group of | Number of people | Before intervention | After 1 month of intervention | After 3 months of intervention |
| Test group | 27 | 49.35±11.13 | 43.98±9.56 | 36.25±7.88#* |
| Control group | 27 | 48.09±12.36 | 47.87±10.94 | 47.39±8.45 |
#: p <0.05 in experimental groups compared to pre-intervention; *: p <0.05 in the experimental group compared to the control group.
As can be seen from the above table, there was almost no change before and after intervention with the control group of substances; after intervention, the patients with yang deficiency constitution in the test group are remarkably reduced relative to the patients before intervention and the patients with yang deficiency constitution in the control group, which shows that the traditional Chinese medicine composition for conditioning yang deficiency constitution can change the yang deficiency constitution, and has no recurrence after 6 months to 1 year.
Typical case
Wu. Star, female, 43 years old, clerical clerk. The doctor visits our hospital through the introduction. The following symptoms are marked: aversion to cold, easy sweating, weak pulse, poor appetite, white and moist coating. After taking the granular formulation of example 1 for 3 months, the symptoms were eliminated and no recurrence occurred after 6 months of best effort.
Wangzhi, male, 59 years old, manager. The symptoms of mental fatigue and easy fatigue are seen; aversion to cold, cold limbs, and deep body; soreness and pain of the waist and knees. After taking the granular preparation of example 1, symptoms are obviously relieved after 1 month, the symptoms are eliminated after 3 months, and no relapse occurs after the consultation after 6 months.
Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention, and they should be construed as being included in the following claims and description.
Claims (8)
1. The traditional Chinese medicine composition for conditioning yang-deficiency constitution is characterized by comprising the following components in parts by weight: 20-60 parts of lucid ganoderma, 20-60 parts of longan pulp, 5-20 parts of eucommia bark, 5-20 parts of cistanche and 1-5 parts of cinnamon.
2. The traditional Chinese medicine composition for conditioning yang-deficiency constitution according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 20-40 parts of lucid ganoderma, 20-40 parts of longan pulp, 5-15 parts of eucommia bark, 5-15 parts of cistanche and 1-3 parts of cinnamon.
3. The traditional Chinese medicine composition for conditioning yang-deficiency constitution according to claim 1, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 30 parts of lucid ganoderma, 30 parts of longan pulp, 10 parts of eucommia bark, 10 parts of cistanche and 2 parts of cinnamon.
4. The use of the composition of any one of claims 1-3 in the preparation of a medicament and health product for regulating yang-deficiency constitution.
5. A Chinese medicinal preparation, which is characterized by being prepared from the Chinese medicinal composition for conditioning yang-deficiency constitution according to any one of claims 1 to 3 and auxiliary materials.
6. The method for preparing a Chinese medicinal preparation according to claim 5, which comprises the steps of:
weighing lucid ganoderma, longan pulp, eucommia ulmoides, cistanche deserticola and cinnamon according to a ratio, crushing the cinnamon, mixing, adding 9-12 times of water, condensing, refluxing and extracting for 2-3 times by boiling water, decocting for 1-2h, controlling the temperature of an aqueous solution to be 95-100 ℃, and combining the extract;
step two, filtering the leaching liquor, and concentrating the filtrate at 40-80 ℃ until the specific gravity is 1.00-1.14 to obtain a concentrate;
and step three, feeding the concentrated solution into a spray dryer for drying to obtain an extract, crushing the extract and auxiliary materials, sieving the extract with a 100-mesh sieve, fully mixing the extract and the auxiliary materials, preparing a soft material by using 60-70% ethanol, extruding the soft material, sieving the soft material with a 14-mesh sieve for granulation, and drying to obtain granules.
7. The method of claim 6, wherein the excipients include a diluent, a thickener, a sweetener, and citric acid.
8. The method according to claim 7, wherein the diluent comprises dextrin and lactose, and the weight ratio of the dextrin to the lactose to the extract is 1: 1-2: 1-2.
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| 胡献国等: "《延年益寿上品：灵芝》", 31 August 2009 * |
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