CN112353736A

CN112353736A - Skin-care conditioning cream for repairing hormone face

Info

Publication number: CN112353736A
Application number: CN202010990149.4A
Authority: CN
Inventors: 黄伟
Original assignee: Guangzhou Zhenji Hemei Biotechnology Co ltd
Current assignee: Guangzhou Zhenji Hemei Biotechnology Co ltd
Priority date: 2020-09-18
Filing date: 2020-09-18
Publication date: 2021-02-12

Abstract

The invention discloses a skin-care conditioning emulsion for repairing hormone face, which comprises arginine/lysine polypeptide, chamomile hydrolat, madecassoside, seawater, fibronectin, a composite seaweed extract, sodium hyaluronate, glycosyl trehalose, oat beta-glucan, a secondary yeast fermentation product filtrate and osmin. The skin-care conditioning cream for repairing hormone faces strengthens skin barriers by balancing grease, repairing cells and moistening skin to improve the skin state, promotes the self-healing capability and toxin expelling of the skin, and realizes the repair of hormone faces under the synergistic effect of multiple effects; has good repairing effect on mild, moderate and severe hormone faces, is not easy to relapse, and can restore healthy skin.

Description

Skin-care conditioning cream for repairing hormone face

Technical Field

The invention belongs to the technical field of cosmetics, and particularly relates to a skin-care conditioning cream for repairing hormone face.

Background

With the improvement of the requirement of people on the beautifying speed, products such as quick acne removal, whitening, freckle removal, anti-aging and the like appear on the market, hormone components are added into part of the products for the purpose of instant product effect, and the hormone face can be caused to appear after the products are used for a long time. The hormone face is also called as hormone-dependent dermatitis (Cortisteroid adjuvant dermatitis), is dermatitis caused by long-term repeated and improper external application of drugs containing Corticosteroid hormones or skin care products such as quick-acting whitening and freckle removing products with illegally added hormones, and seriously damages the normal physiological structure and function of the skin. Once stopping taking the medicine, the original skin diseases can recur and aggravate, the ointment or the cosmetics are continuously used, the symptoms are rapidly relieved, and the symptoms are repeated after stopping taking the medicine, so that the vicious circle is formed.

The main manifestations of sensitive skin can be summarized as dry, itchy, swollen, painful, red. "hormonal faces" are manifested by polymorphic skin lesions such as erythema, papules, flushing, telangiectasia, dry desquamation, swelling, enlarged pores, pigment changes, acne-like or rosaceae-like symptoms; and the skin damage degree is serious, the skin damage attacks repeatedly and is stubborn and difficult to heal, and the health and the beauty of the skin are influenced. On the other hand, the skin barrier is completely destroyed, and mild causes can lead to allergic dermatitis, a hormone face.

Currently, the more traditional treatment regimen for treating hormone faces is to continue using hormone ointment in dermatology under the direction of a cosmetologist, gradually and slowly reducing the dose and stopping the dose to relieve the symptoms. The other is a naked face treatment method, namely, the skin is not washed, does not touch or touch and is not stimulated by any outside world, and the skin can freely develop along with the self metabolism of the skin; however, the naked face treatment method is only suitable for patients with mild disease, and the patients can recover within a few days, while the patients with severe disease need 3-5 years of repair time, and the repair time is too long.

Disclosure of Invention

The invention aims to provide a skin-care conditioning cream for repairing a hormone face, which aims to improve the hormone face and help repair the skin.

In order to achieve the purpose, the invention provides the following technical scheme:

the skin-care conditioning milk for repairing hormone face comprises the following raw materials in percentage by mass: arginine/lysine polypeptide 0.12-0.33%, chamomile pure water 0.7-2.6%, madecassoside 0.01-0.05%, sea water 0.2-0.85%, fibronectin 0.03-0.13%, composite seaweed extract 0.1-1%, sodium hyaluronate 0.04-0.12%, glycosyl trehalose 0.11-0.35%, oat beta-glucan 0.8-3.4%, yeast fermentation product filtrate 4.5-9.8%, and oshusuo 0.1-0.45%.

Preferably, the skin-care conditioning milk for repairing hormone face comprises the following raw materials in percentage by mass: arginine/lysine polypeptide 0.15-0.3%, chamomile pure water 1.5-2.5%, madecassoside 0.025-0.05%, sea water 0.3-0.65%, fibronectin 0.08-0.1%, composite seaweed extract 0.3-0.8%, sodium hyaluronate 0.05-0.1%, glycosyl trehalose 0.15-0.3%, oat beta-glucan 1.5-3%, yeast bifidus fermentation product filtrate 6-8%, and oshmannine 0.2-0.45%.

More preferably, the skin-care conditioning milk for repairing hormone faces further comprises the following raw materials in percentage by mass: 0.2 to 0.5 percent of coconut acyl hydrolyzed oat protein potassium, 0.2 to 0.5 percent of cetostearyl alcohol, 0.2 to 0.8 percent of glycerol stearate, 0.5 to 1 percent of glycerol oleate, 0.5 to 1 percent of polyglycerol-6 stearate, 0.5 to 1 percent of polyglycerol-6 behenate, 1 to 3 percent of squalane, 1 to 3 percent of jojoba seed oil, 1 to 3 percent of caprylic/capric triglyceride and 0.04 to 0.08 percent of xanthan gum, 60.05-0.08% of polyacrylate cross-linked polymer, 0.05-0.1% of acryloyl dimethyl taurate/VP copolymer, 0.3-0.55% of phenoxyethanol, 0.1-0.2% of p-hydroxyacetophenone, 1-2% of 1,2 pentanediol, 1-5% of glycerol, 1-5% of propylene glycol, 0.1-0.25% of magnesium aluminum silicate and deionized water to 100%.

A skin care milk for repairing hormone face is prepared from compound Sargassum extract including Undaria pinnatifida extract, Sargassum extract, and Fucus vesiculosus extract.

A skin care milk for repairing hormone face is prepared from sodium hyaluronate through acetylating.

A preparation method of skin-care conditioning milk for repairing hormone face comprises the following steps:

1) accurately weighing potassium cocoyl hydrolyzed oat protein, cetostearyl alcohol, glyceryl stearate, glyceryl oleate, polyglycerol-6 stearate, polyglycerol-6 behenate, squalane, jojoba seed oil 1-3%, and caprylic/capric triglyceride, placing in an oil phase pan, heating while stirring until completely dissolved, and keeping the temperature for 5-6min to obtain phase A;

2) accurately weighing xanthan gum, polyacrylate crosslinked polymer-6, acryloyl dimethyl ammonium taurate/VP copolymer, glycerol, propylene glycol, aluminum magnesium silicate and deionized water, placing in a water phase pot, heating while stirring until completely dissolving, and keeping the temperature for 5-6min to obtain phase B;

3) pouring the phase A into the phase B, homogenizing and emulsifying at the rotating speed of 3200-;

4) and (3) cooling the phase C to 40-45 ℃ while stirring, sequentially adding p-hydroxyacetophenone, 1,2 pentanediol, arginine/lysine polypeptide, chamomile hydrolat, madecassoside, seawater, fibronectin, a composite seaweed extract, sodium hyaluronate, glycosyl trehalose, oat beta-glucan, a yeast-bifida fermentation product filtrate and oshusuo, uniformly stirring, detecting qualified products and discharging to prepare the skin-care conditioning milk for repairing hormone faces.

Arginine/lysine polypeptide is a small molecular peptide derived from a genetic engineering fermentation technology, is a non-synthetic polypeptide, is non-animal collagen, repairs skin barriers, and improves sensitive muscles.

Madecassoside, a potent and highly pure active ingredient, is one of the main substances present in centella asiatica. Has antipruritic, anti-erythema and anti-desquamation effects, and can relieve sensitive skin, atopic dermatitis and psoriasis skin, and improve erythema, desquamation and roughness of skin.

The seawater is deep seawater which is permeated into geological layers with abundant nutrients and is balanced by nature, contains abundant mineral substances and trace elements, supplements the trace elements and mineral substances of the skin and enhances the cohesion of skin cells; can endow the skin with unlimited activity, glow and refresh the skin; active water, which can preserve moisture and enhance vitality and vitality of cells; the skin is shiny and glowing, and the skin quality is thoroughly improved; promoting penetration and absorption, enhancing toxin expelling and detoxifying capability of skin, resisting inflammation and allergy/repair, and thoroughly improving skin quality.

The sodium hyaluronate is acetylated sodium hyaluronate (AcHA) and is obtained by acetylating natural moisturizing factor sodium Hyaluronate (HA), so that the affinity and adsorbability of HA to skin are enhanced, and the moisturizing performance of HA is improved. The acetyl group is lipophilic, so that AcHA can be firmly adsorbed on the surface of the skin, has small molecular weight and can quickly permeate into the horny layer, so that the AcHA can reduce water loss on the surface of the skin and increase internal water accumulation, can permeate into the epidermis to hydrate and soften the horny layer, acts inside and outside simultaneously, plays a double moisturizing effect, can repair damaged epidermal cells, enhances the barrier of the horny layer, improves the dry and rough state of the skin, and enables the skin to be soft and elastic.

Fibronectin is a protein active substance widely existing in human bodies, plays a central role in cell adhesion, can regulate cell polarity, differentiation and growth, is widely involved in the processes of skin cell migration, proliferation, hemostasis, tissue repair and the like, regulates an immune cell system to remove harmful substances at the damaged tissue, has the functions of repair and inflammation resistance, has the similar function of growth factors, has the biological function of cell regeneration repair, but has mild action and no side effect; strengthening the stratum corneum, improving the resistance of the stratum corneum to external stimulation, guiding macromolecules to be absorbed through skin, permeating into the skin dermis, stimulating cells to generate nutrient substances (collagen, hyaluronic acid, small molecular peptides and the like), and promoting the metabolism of the cells; damaged and broken fibroblasts can be repaired more quickly, the smoothing of dynamic lines such as the eye circumference and the like is accelerated, and the depth of static lines such as few raised lines and the like is reduced; simultaneously has the functions of removing acne and lightening acne marks.

The seaweed extract is rich in methionine and cystine, integrates moisture retention and tightening performance, can regulate the secretion of dry and oily skin, regulate the water-oil balance of the skin, and effectively tighten and tighten skin pores; can reactivate 14 related genes in the extracellular matrix of the dermis layer, and restore the vitality of the skin, so that the skin is younger.

The oshusuo comprises water, glycerol, flos Matricariae Chamomillae (Chamomilla RECUTITA) flower extract, flos Malva sylvestris (MALVA SYLVESTRIS) flower extract, radix Paeoniae (Paeonia alba) root extract, flos Lonicerae (Lonicera JAPONICA) flower extract, herba Taraxaci (Taraxacum OFFICINALE) rhizome/root extract, herba Violae (Viola YEDOENSIS) extract, Aloe BARBADENSIS (Aloe BARBADENSIS) leaf juice, and ethylhexyl glycerol, plant allergy relieving essence extracted from various plants,

oat beta-glucan: the skin care product has the advantages of stimulating the growth of an immune system and fibroblasts, accelerating the movement of keratinocytes, promoting wound healing, promoting the synthesis of collagen and hyaluronic acid, improving the skin barrier repair function after laser dermabrasion, improving the powerful moisturizing effect, having the moisturizing effect superior to that of hyaluronic acid, helping to reduce wrinkles and rough skin, having good film forming property, protecting the skin from being damaged by external stimulation and leading the fresh and tender skin to grow healthily.

The glycosyl trehalose can form a protective film on the surface of skin, resist skin aging and keep skin vitality. The skin care product has the advantages of soothing and firming the skin, increasing the smoothness of the skin, moistening the skin, making the skin feel soft and giving the skin a smooth feeling. Can protect cells irradiated with ultraviolet rays, activate cells, maintain moisture, prevent skin dryness, and has anti-inflammatory effect.

Secondary split yeast fermentation product filtrate: the anti-aging active substance extracted from the lysate of the probiotics, namely bifidobacterium, by applying biotechnology can effectively protect skin from being damaged by ultraviolet rays, support the endogenous protection mechanism of the skin, resist skin premature senility, namely photoaging, promote cell repair by effectively activating the anti-immunosuppression process at the cellular level and promote cell regeneration, so that the resistance to adverse environmental influences is enhanced; because the skin regeneration speed is accelerated, the effects of removing wrinkles, repairing, moisturizing and enhancing the skin elasticity are exerted, the old cutin is removed, and the skin is white, tender and bright like molting.

Compared with the prior art, the invention has the beneficial effects that:

the face-care conditioning cream with the repairing hormone provided by the invention can nourish skin, promote blood circulation, cool and calm and relieve skin, repair hormone face, shrink pores, recover healthy skin and beautify skin. Inhibiting inflammatory reaction of skin, relieving adverse reaction symptom of skin, improving inflammation, and promoting repair of hormone face and removing toxic substance; activating cell genes, promoting the self-healing and repairing capability of skin, and recovering the healthy metabolism of skin; promoting epidermal cell proliferation, accelerating cell activity recovery, repairing damaged epidermal cells, promoting tissue regeneration, enhancing stratum corneum barrier function, and improving natural resistance of skin; the skin can be drunk with enough moisture to strengthen the skin barrier, adjust the water-oil balance of the skin and provide a good epidermal environment for skin repair.

Drawings

The above features and advantages of the present invention will become more apparent from the following detailed description when taken in conjunction with the accompanying drawings, in which:

FIG. 1 is a graph of water loss data showing that skin water loss can be reduced to enhance skin barrier function.

Detailed Description

The present invention will be described in further detail with reference to specific embodiments in the form of examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.

Example 1

The skin-care conditioning milk for repairing hormone faces comprises the following raw materials in percentage by mass: arginine/lysine polypeptide 0.2%, chamomile hydrolat 2%, madecassoside 0.035%, sea water 0.45%, fibronectin 0.08%, composite seaweed extract 0.5%, sodium hyaluronate 0.1%, glycosyl trehalose 0.25%, oat beta-glucan 2%, yeast fermentation product filtrate 6.5%, oshmannine 0.4%, potassium cocoyl-hydrolyzed oat protein 0.35%, cetostearyl alcohol 0.2%, glyceryl stearate 0.5%, glyceryl oleate 0.6%, polyglyceryl-6 stearate 0.8%, polyglyceryl-6 behenate 0.8%, squalane 2%, jojoba seed oil 2.5%, caprylic/capric triglyceride 2%, xanthan gum 0.06%, polyacrylate cross-linked polymer-60.08%, ammonium acryloyldimethyl taurate/VP copolymer 0.08%, phenoxyethanol 0.4%, p-hydroxyacetophenone 0.15%, 1,2 pentanediol 1.5%, and, 4% of glycerin, 3% of propylene glycol, 0.15% of magnesium aluminum silicate and 100% of deionized water.

A preparation method of the skin-care conditioning milk comprises the following steps:

1) accurately weighing potassium cocoyl hydrolyzed oat protein, cetostearyl alcohol, glyceryl stearate, glyceryl oleate, polyglycerol-6 stearate, polyglycerol-6 behenate, squalane, jojoba seed oil 1-3% and caprylic/capric triglyceride, placing in an oil phase pot, heating while stirring until the mixture is completely dissolved, and keeping the temperature for 6min to obtain phase A;

2) accurately weighing xanthan gum, polyacrylate crosslinked polymer-6, acryloyl dimethyl ammonium taurate/VP copolymer, glycerol, propylene glycol, aluminum magnesium silicate and deionized water, placing in a water phase pot, heating while stirring until completely dissolved, and keeping the temperature for 6min to obtain phase B;

3) pouring the phase A into the phase B, homogenizing and emulsifying at 3800r/min for 5min, stirring for 8min to obtain phase C;

4) and (3) cooling the phase C to 43 ℃ while stirring, sequentially adding p-hydroxyacetophenone, 1, 2-pentanediol, arginine/lysine polypeptide, chamomile hydrosol, madecassoside, seawater, fibronectin, a composite seaweed extract, sodium hyaluronate, glycosyl trehalose, oat beta-glucan, a yeast-bifida fermentation product filtrate and oshusuo while stirring, uniformly stirring, detecting qualified products, and discharging to prepare the skin-care conditioning milk for repairing hormone faces.

Example 2

The skin-care conditioning milk for repairing hormone faces comprises the following raw materials in percentage by mass: arginine/lysine polypeptide 0.15%, chamomile hydrolat 1.5%, madecassoside 0.025%, sea water 0.3%, fibronectin 0.08%, complex seaweed extract 0.3%, sodium hyaluronate 0.05%, glycosyl trehalose 0.15%, oat beta-glucan 1.5%, yeast dehiscence fermentation product filtrate 6%, osmin 0.2%, potassium cocoyl hydrolyzed oat protein 0.2%, cetostearyl alcohol 0.2%, glyceryl stearate 0.2%, glyceryl oleate 0.5%, polyglycerol-6 stearate 0.5%, polyglycerol-6 behenate 0.5%, squalane 1%, jojoba seed oil 1%, caprylic/capric triglyceride 1%, xanthan gum 0.04%, polyacrylate cross-linked polymer-60.05%, ammonium acryloyldimethyl taurate/VP copolymer 0.05%, phenoxyethanol 0.3%, p-hydroxyacetophenone 0.1%, 1,2 pentanediol 1%, sodium alginate, sodium hyaluronate, sodium alginate, sodium, 1% of glycerol, 1% of propylene glycol, 0.1% of magnesium aluminum silicate and 100% of deionized water.

1) accurately weighing potassium cocoyl hydrolyzed oat protein, cetostearyl alcohol, glyceryl stearate, glyceryl oleate, polyglycerol-6 stearate, polyglycerol-6 behenate, squalane, jojoba seed oil 1-3% and caprylic/capric triglyceride, placing in an oil phase pot, heating while stirring until the mixture is completely dissolved, and keeping the temperature for 5min to obtain phase A;

2) accurately weighing xanthan gum, polyacrylate crosslinked polymer-6, acryloyl dimethyl ammonium taurate/VP copolymer, glycerol, propylene glycol, aluminum magnesium silicate and deionized water, placing in a water phase pot, heating while stirring until completely dissolving, and keeping the temperature for 5min to obtain phase B;

3) pouring the phase A into the phase B, homogenizing and emulsifying at 4200r/min for 3.5min, stirring for 8min to obtain phase C;

4) and (3) cooling the phase C to 40 ℃ while stirring, sequentially adding p-hydroxyacetophenone, 1, 2-pentanediol, arginine/lysine polypeptide, chamomile hydrosol, madecassoside, seawater, fibronectin, a composite seaweed extract, sodium hyaluronate, glycosyl trehalose, oat beta-glucan, a yeast-bifida fermentation product filtrate and oshusuo, uniformly stirring, detecting qualified products, and discharging to prepare the skin-care conditioning milk for repairing hormone faces.

Example 3

The skin-care conditioning milk for repairing hormone faces comprises the following raw materials in percentage by mass: arginine/lysine polypeptide 0.3%, chamomile hydrolat 2.5%, madecassoside 0.05%, sea water 0.65%, fibronectin 0.1%, complex seaweed extract 0.3-0.8%, sodium hyaluronate 0.1%, glycosyl trehalose 0.3%, oat beta-glucan 3%, yeast fermentation product filtrate 8%, osmin 0.45%, potassium cocoyl-hydrolyzed oat protein 0.5%, cetostearyl alcohol 0.5%, glyceryl stearate 0.8%, glyceryl oleate 1%, polyglyceryl-6 stearate 1%, polyglyceryl-6 behenate 1%, squalane 3%, jojoba seed oil 3%, caprylic/capric triglyceride 3%, xanthan gum 0.08%, polyacrylate crosspolymer-60.08%, ammonium acryloyldimethyl taurate/VP copolymer 0.1%, ethanol 0.55%, p-hydroxy-phenyl 0.2%, 1,2 percent of pentanediol 2 percent, 5 percent of glycerol, 5 percent of propylene glycol, 0.25 percent of magnesium aluminum silicate and deionized water to 100 percent.

3) pouring the phase A into the phase B, homogenizing and emulsifying at 3200r/min for 6min, and stirring for 10min to obtain phase C;

4) and (3) cooling the phase C to 45 ℃ while stirring, sequentially adding p-hydroxyacetophenone, 1, 2-pentanediol, arginine/lysine polypeptide, chamomile hydrosol, madecassoside, seawater, fibronectin, a composite seaweed extract, sodium hyaluronate, glycosyl trehalose, oat beta-glucan, a yeast-bifida fermentation product filtrate and oshusuo, uniformly stirring, detecting qualified products, and discharging to prepare the skin-care conditioning milk for repairing hormone faces.

Comparative example 1

The difference from example 1 is that oat beta-glucan, yeast bifidus fermentation product filtrate were not added, other raw materials and preparation method were the same as example 1.

Comparative example 2

The difference from example 1 is that the complex seaweed extract, sea water, fibronectin were not added, and other raw materials and preparation methods were the same as example 1.

Comparative example 3

The difference from example 1 is that arginine/lysine polypeptide and madecassoside are not added, and other raw materials and preparation methods are the same as example 1.

Efficacy verification

The hormone face skin was selected for a total of 600 cases. Wherein, the skin of the mild hormone face comprises 200 cases, the skin of the moderate hormone face comprises 200 cases, and the skin of the severe hormone face comprises 200 cases. The

treatment groups

1,2, 3, 1,2 and 3 were divided into 4 groups, 100 of which had the same number of mild, moderate and severe hormone facial skin cases. Treatment group 1 hormone facial restoration was performed using the product prepared in example 1; treatment group 2 hormone face treatment was performed using the product prepared in example 2; treatment group 3 hormone face treatment was performed using the product prepared in example 3. Control group 1 was treated with hormone face using the product prepared in comparative example 1; control group 2 was treated with hormone face using the product prepared in comparative example 2; control group 3 was subjected to hormone face treatment using the product prepared in comparative example 3. The using method comprises the following steps: after cleansing the face every morning and evening, the products of examples 1 to 3 and comparative examples 1 to 3 were applied uniformly to the facial skin and absorbed by patting with finger bells.

The curative effect standard is as follows:

the effect is shown: after 1h, the symptoms of skin redness, itching and pain disappear.

For mild hormone face skin, after 1 day of use, pimples become small and basically disappear, and skin surface inflammation gradually disappears; after 3 days of use, most hormone faces can be subjected to the withdrawal phenomenon with different degrees, and the symptoms are red, swollen, itchy and papule; after 5 days of use, the skin in the withdrawal period shows red, swelling, pimple and exudation symptoms which are gradually faded, and the appearance of the skin mainly shows dryness and skin fading and gradually approaches to normal; after insisting on using for 15 days, the appearance and the function of the skin are almost recovered to be normal. No recurrence within half a year.

For the moderate hormone face skin, after 2 days of use, erythema, pimple become small, red and swollen parts basically disappear, and skin surface inflammation gradually disappears. After 4 days of use, most hormone faces will be withdrawn with different degrees, which is manifested as red, swollen, itchy and papule. After 8 days of use, the skin in the withdrawal period shows red, swelling, pimple and exudation symptoms which are gradually faded, and the appearance of the skin mainly shows dryness and skin fading and gradually approaches to normal; after 25 days of use, skin appearance and function were nearly normal. No recurrence within half a year.

For severe hormone face skin, after 3 days, the pimple is seriously swollen, the large blister is small, the red swelling part basically disappears, and the skin surface inflammation gradually disappears. After 8 days of use, most hormone faces will be in different degrees of withdrawal, blisters and exudation. After 15 days of use, the skin in the withdrawal period shows red, swollen, pimple and exudation symptoms which are gradually faded, and the appearance of the skin mainly shows dryness and skin fading and gradually approaches to normal; after 38 days of use, skin appearance and function were nearly normal. No recurrence within half a year.

The method has the following advantages: after 2 hours of use, the symptoms of skin redness, itching and pain disappear.

For mild hormone face skin, after 2 days of use, the pimple becomes small and basically disappears, and the inflammation on the surface of the skin gradually disappears; after 5 days of use, most hormone faces can be subjected to the withdrawal phenomenon with different degrees, and the symptoms are red, swollen, itchy and papule; after 7 days of use, the skin in the withdrawal period shows red, swelling, pimple and exudation symptoms which are gradually faded, and the appearance of the skin mainly shows dryness and skin fading and gradually approaches to normal; after insisting on using for 20 days, the appearance and the function of the skin are almost recovered to be normal. No recurrence within half a year.

For the moderate hormone face skin, after 3 days of use, erythema, pimple become small, red and swollen parts basically disappear, and skin surface inflammation gradually disappears. After 6 days of use, most hormone faces will be in different degrees of withdrawal, which is manifested as red, swollen, itchy and papular. After 10 days of use, the skin in the withdrawal period shows red, swelling, pimple and exudation symptoms which are gradually faded, and the appearance of the skin mainly shows dryness and skin fading and gradually approaches to normal; after 30 days of use, skin appearance and function were nearly normal. No recurrence within half a year.

For severe hormone face skin, after 4 days of use, the pimple is seriously swollen, the blister is small, the red swelling part basically disappears, and the skin surface inflammation gradually disappears; after 13 days of use, most hormone faces will be in different degrees of withdrawal, blisters and exudation. After 18 days of use, the skin in the withdrawal period shows red, swollen, pimple and exudation symptoms which are gradually faded, and the appearance of the skin mainly shows dryness and skin fading and gradually approaches to normal; after 45 days of use, skin appearance and function were nearly normal. No recurrence within half a year.

And (4) invalidation: after 3 days of use, there was no change or more severe skin symptoms. Or recurrent hair within half a year.

As a result:

item	Number of examples	Significant effects/examples	Effective/example	Invalid/example	Total effective rate/%)
						Example 1	100 examples of	59	40	1	99
Example 2	100 examples of	45	49	6	94
						Example 3	100 examples of	42	51	7	93
Comparative example 1	100 examples of	25	35	40	60
						Comparative example 2	100 examples of	23	38	45	61
Comparative example 3	100 examples of	35	42	27	77

And (4) conclusion: the data in the table show that compared with the comparative example, the examples have better hormone face repairing effect, have better repairing effect on mild, moderate and severe hormone faces, and obviously fine and smooth skin pores.

TEWL test

The water dispersion loss (TEWL) of the skin of the subject was measured separately using a test instrument, Tewameter TM3000, after the product was applied by the volunteers.

And (4) conclusion: as can be seen from the data in figure 1, the repair hormone facial skin care conditioning milk provided by the invention can improve the water retention function of skin, reduce the water dispersion amount of the skin, continuously supplement water for the skin and enhance the barrier function of the skin.

Although the preferred embodiments of the present patent have been described in detail, the present patent is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present patent within the knowledge of those skilled in the art.

Claims

1. The skin-care conditioning milk for repairing hormone faces is characterized by comprising the following raw materials in percentage by mass: arginine/lysine polypeptide 0.12-0.33%, chamomile pure water 0.7-2.6%, madecassoside 0.01-0.05%, sea water 0.2-0.85%, fibronectin 0.03-0.13%, composite seaweed extract 0.1-1%, sodium hyaluronate 0.04-0.12%, glycosyl trehalose 0.11-0.35%, oat beta-glucan 0.8-3.4%, yeast fermentation product filtrate 4.5-9.8%, and oshusuo 0.1-0.45%.

2. The skin-care conditioning milk for repairing hormone faces, according to claim 1, is characterized by comprising the following raw materials in percentage by mass: arginine/lysine polypeptide 0.15-0.3%, chamomile pure water 1.5-2.5%, madecassoside 0.025-0.05%, sea water 0.3-0.65%, fibronectin 0.08-0.1%, composite seaweed extract 0.3-0.8%, sodium hyaluronate 0.05-0.1%, glycosyl trehalose 0.15-0.3%, oat beta-glucan 1.5-3%, yeast bifidus fermentation product filtrate 6-8%, and oshmannine 0.2-0.45%.

3. The skin care conditioning milk for repairing hormone faces as claimed in claim 1, further comprising the following raw materials by mass percent: 0.2 to 0.5 percent of coconut acyl hydrolyzed oat protein potassium, 0.2 to 0.5 percent of cetostearyl alcohol, 0.2 to 0.8 percent of glycerol stearate, 0.5 to 1 percent of glycerol oleate, 0.5 to 1 percent of polyglycerol-6 stearate, 0.5 to 1 percent of polyglycerol-6 behenate, 1 to 3 percent of squalane, 1 to 3 percent of jojoba seed oil, 1 to 3 percent of caprylic/capric triglyceride and 0.04 to 0.08 percent of xanthan gum, 60.05-0.08% of polyacrylate cross-linked polymer, 0.05-0.1% of acryloyl dimethyl taurate/VP copolymer, 0.3-0.55% of phenoxyethanol, 0.1-0.2% of p-hydroxyacetophenone, 1-2% of 1,2 pentanediol, 1-5% of glycerol, 1-5% of propylene glycol, 0.1-0.25% of magnesium aluminum silicate and deionized water to 100%.

4. The skin care conditioning milk for repairing hormone face as claimed in any one of claims 1-2, wherein the compound seaweed extract comprises two or more of Undaria pinnatifida extract, Sargassum fusiforme extract, and Fucus vesiculosus extract.

5. The skin care conditioning milk for repairing hormone face according to any one of claims 1-2, wherein the sodium hyaluronate is acetylated sodium hyaluronate.

6. The skin care conditioning milk for repairing hormone face according to any one of claims 1 to 3, characterized in that the preparation method of the skin care conditioning milk comprises the following steps: