CN111999511A - Real-time monitoring method - Google Patents
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- CN111999511A CN111999511A CN201910391123.5A CN201910391123A CN111999511A CN 111999511 A CN111999511 A CN 111999511A CN 201910391123 A CN201910391123 A CN 201910391123A CN 111999511 A CN111999511 A CN 111999511A
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- 238000012544 monitoring process Methods 0.000 title claims abstract description 73
- 238000000034 method Methods 0.000 title claims abstract description 30
- 239000007788 liquid Substances 0.000 claims abstract description 82
- 238000001514 detection method Methods 0.000 claims abstract description 50
- 230000003287 optical effect Effects 0.000 claims abstract description 15
- 239000000523 sample Substances 0.000 claims description 38
- 239000000126 substance Substances 0.000 claims description 19
- 230000005284 excitation Effects 0.000 claims description 9
- 239000000463 material Substances 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 8
- 230000005540 biological transmission Effects 0.000 claims description 7
- 230000031700 light absorption Effects 0.000 claims description 4
- 239000003365 glass fiber Substances 0.000 claims description 3
- 238000002835 absorbance Methods 0.000 claims description 2
- 239000000835 fiber Substances 0.000 claims description 2
- 238000011160 research Methods 0.000 abstract description 3
- 239000003814 drug Substances 0.000 description 13
- 231100000331 toxic Toxicity 0.000 description 13
- 230000002588 toxic effect Effects 0.000 description 13
- 230000000052 comparative effect Effects 0.000 description 9
- 238000003018 immunoassay Methods 0.000 description 5
- MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 4
- 231100000167 toxic agent Toxicity 0.000 description 4
- 239000003440 toxic substance Substances 0.000 description 4
- 241000283707 Capra Species 0.000 description 3
- 241001529936 Murinae Species 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000013307 optical fiber Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00207—Handling bulk quantities of analyte
- G01N2035/00227—Monitoring a process (online)
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- General Physics & Mathematics (AREA)
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- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Abstract
The invention discloses a real-time monitoring method, which specifically comprises the following steps: (1) installing an electric monitoring component or/and an optical monitoring component or/and an acoustic monitoring component on a flow channel of the detection instrument; (2) the detection instrument obtains the parameters of the liquid flowing through the flow passage through the feedback of the electric monitoring part or/and the optical monitoring part or/and the acoustic monitoring part. By adopting the technical scheme, the parameters of the liquid passing through the flow channel are obtained through the feedback of the monitoring part by selecting the proper monitoring part; thereby acquiring the condition of the liquid flowing in the flow channel in real time, and controlling the liquid level of the liquid flowing in the flow channel according to the use condition of the detection instrument; the detection accuracy and the detection efficiency can be effectively improved; meanwhile, the automation of the detection instrument is further improved; the real-time monitoring method is simple and controllable, and is suitable for wide popularization; the purpose of monitoring the liquid parameters in the flow channel is as follows: opening or breaking the flow channel, or detecting the property of the liquid in the flow channel to assist the experimental research.
Description
Technical Field
The invention belongs to the technical field of medical detection, and particularly relates to a real-time monitoring method.
Background
The immunoassay method is a method for detecting toxicants by using antibodies competitively binding the toxicants and labeled toxicants, and can be used for screening tests of certain toxicants. When the non-labeled toxic medicine is not added, the antibody is completely combined with the labeled toxic medicine to generate a labeled toxic medicine antibody compound. After the non-labeled toxic medicine is added, the non-labeled toxic medicine is also combined with the antibody to generate a non-labeled toxic medicine antibody compound, so that the combination reaction of the labeled toxic medicine and the antibody is inhibited, and the content of the labeled toxic medicine in a generated product is reduced. If the amounts of antibody and labelled toxic drug are fixed, there is a functional relationship between the amount of unlabelled toxic drug added and the amount of labelled toxic drug in the complex. The proper method is selected to detect the labeled toxic medicine in the compound, and then the quantity immunoassay method of the toxic medicine in the detection material can be calculated according to the method, besides the classical enzyme-linked immunoassay method, the chemiluminescence immunoassay method, the fluorescence immunoassay method, the electrochemical immunoassay method and the like are also adopted, and the methods are mainly used for detection through an enzyme-labeling instrument. When detecting the sample through some detecting instrument or detection chip, can't carry out real-time supervision to the sample at present, and when detecting, the sample has or not got into detecting instrument or detection chip etc. and is very important to the testing result, whether have through real-time supervision sample get into the runner and the liquid level how much, so not only can guarantee the degree of accuracy of sample, can also improve detection efficiency.
Therefore, there is a need to develop a real-time monitoring method that has a simple structure and a controllable operation and can monitor the condition of the liquid in the flow channel of the detecting instrument in real time.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a real-time monitoring method which is simple and controllable in operation and can monitor the liquid condition in a flow channel in a detection instrument in real time, so that the automation of the detection instrument can be further improved.
In order to solve the technical problems, the technical scheme adopted by the invention is that the real-time monitoring method specifically comprises the following steps:
(1) installing an electric monitoring component or/and an optical monitoring component or/and an acoustic monitoring component on a flow channel of the detection instrument;
(2) the detection instrument obtains the parameters of the liquid flowing through the flow passage through the feedback of the electric monitoring part or/and the optical monitoring part or/and the acoustic monitoring part.
By adopting the technical scheme, the parameters of the liquid passing through the flow channel are obtained through the feedback of the monitoring part by selecting the proper monitoring part; thereby acquiring the condition of the liquid flowing in the flow channel in real time, and controlling the liquid level of the liquid flowing in the flow channel according to the use condition of the detection instrument; the detection accuracy and the detection efficiency can be effectively improved; meanwhile, the automation of the detection instrument is further improved; the real-time monitoring method is simple and controllable, and is suitable for wide popularization. The purpose of monitoring the liquid parameters in the flow channel is as follows: opening or breaking the flow channel, or detecting the property of the liquid in the flow channel to assist the experimental research.
The invention is further improved in that when the electrical monitoring component is adopted in the step (1), the specific steps are as follows: and electrode plates are respectively arranged on two sides of the flow channel, are respectively contacted with the probe of the detection instrument and are used for testing capacitance values when different liquids circulate, so that the flow channel is monitored and controlled to circulate by different liquids through capacitance values or voltage or current or resistance. The conductive electrodes are respectively arranged on two sides of the flow channel, when different liquid reagents pass through, the conductive condition is changed, and a detection instrument can detect specific parameters for judging whether the liquid passes through or not and whether the passing reagents are different or not.
As a preferred technical scheme of the invention, the diameter width of the flow channel is 1-10 mm, and the electrode plate interval is 5-500 mm.
The invention is further improved in that when the light monitoring component is adopted in the step (1), the specific steps are as follows: one side of the flow channel is provided with a transmitting light probe for excitation, and the other side is provided with a receiving probe for reading an absorbance value or a fluorescence value; or the emitting light probe is arranged on one side of the flow channel for excitation, and the receiving probe is arranged for reading the light absorption value or the fluorescence value. Wherein the wavelength of the emitted light and the selection of the fluorescent substance are determined according to the detection items.
As a preferable embodiment of the present invention, when the light monitoring member is used in the step (1), a filter structure is further provided at the front end of the flow channel, and the filter structure is treated with a fluorescent substance. When the liquid flows through, the fluorescent substance carried by the liquid passes through the monitoring component, and after the liquid is irradiated by the exciting light, the fluorescent substance generates fluorescence which is monitored by the receiving probe, the liquid flowing through the flow channel is judged, and the concentration of the fluorescent substance in the flowing liquid can be judged.
As a preferred technical solution of the present invention, when the light monitoring component is used in the step (1), the specific steps are as follows: s11, arranging light excitation emitted by the fiber probe on one side of the flow channel, and arranging emitted light received by the optical filter on the other side; or one side of the flow channel is provided with a transmitting light probe for excitation and a receiving probe for reading a light absorption value or a fluorescence value;
s12, arranging filter paper processed by fluorescent material at the front end of the flow channel as the filter structure, or adding fluorescent material at the front end of the flow channel, when liquid flows through, the filter paper carries the fluorescent material to pass through the monitoring component, after the liquid is irradiated by exciting light, fluorescence is generated and is monitored by the receiving probe, thereby judging that liquid flows through the flow channel, and judging the concentration of the fluorescent material in the flowing liquid. Wherein, a filtering structure is adopted or fluorescent substances are directly added into the flow channel, and when the fluorescent substances flow through, signals can be detected; the choice of the fluorescent substance and the antibody is not limited and depends on the detection item.
The invention is further improved in that when the sound monitoring component is adopted in the step (1), the concrete steps are as follows: arranging a probe at one side of the flow channel for ultrasonic emission and receiving reflected sound waves; or a probe is arranged on one side of the flow channel for transmitting ultrasonic waves, and reflected sound waves are received on the other side of the flow channel; thereby judging the difference of the liquid in the flow passage; when liquid flows through the liquid level sensor, the transmission speed of sound waves is increased, the receiving time is shortened, and liquid level detection is carried out according to the transmission speed.
In a preferred embodiment of the present invention, the flow channel has a width of 3mm and a thickness of 2mm, and the filter paper has a size of 3mm by 2mm by 1mm and is placed at the front end of the flow channel. And selecting filter paper with corresponding parameters according to the parameters of the flow channel.
As a preferred technical scheme, the filter paper is made of glass fiber paper, and the filter paper is soaked in goat anti-mouse IgG antibody combined with FITC fluorescent substance for at least 8 hours at the concentration of 1-10 mg/ml and then dried.
As a preferred technical scheme of the invention, the diameter of the probe is 0.5-10 mm, and the ultrasonic frequency is 10MHZ-50 MHZ. Wherein the diameter of the probe is preferably 0.5-3 mm.
Compared with the prior art, the invention has the beneficial effects that: by selecting a proper monitoring part, the parameters of the liquid passing through the flow passage are obtained through the feedback of the monitoring part; therefore, the condition of the liquid flowing in the flow channel is acquired in real time, the interception and the like of the liquid flowing in the flow channel are controlled according to the use condition of the detection instrument, or the attribute of the liquid flowing is detected, so as to assist experimental research. The detection accuracy and the detection efficiency can be effectively improved; meanwhile, the automation of the detection instrument is further improved; the real-time monitoring method is simple and controllable, and is suitable for wide popularization.
Detailed Description
Example 1: the real-time monitoring method specifically comprises the following steps:
(1) installing an electric monitoring part on a flow channel of the detection instrument;
(2) the detection instrument obtains parameters of the liquid flowing through the flow passage through the feedback of the electric monitoring part;
two electrode plates are respectively arranged on two sides of the flow channel, are respectively contacted with two probes of the detection instrument and are used for testing capacitance values when different liquids flow, so that the flow channel for the different liquids is monitored and controlled through the capacitance values; the diameter width of the flow channel is 1mm, and the distance between the two electrode plates is 5 mm; examples 2 to 4 and comparative example 1 and example 1 all used the same electrical monitoring member, except that the liquid flowing in the flow channel was different in type, and the capacitance values measured when different liquids were flowing were as shown in table 1 below.
Table 1 shows the capacitance values of the liquid flowing in examples 1 to 4 and comparative example 1
The results from table 1 above show that: different flowing liquids can cause the change of capacitance value between the two electrodes, and whether different liquids flow through the flow channel can be distinguished by measuring the values.
In order to check whether the liquid level detection and the valve control can be performed using the flow channel in which the electrical monitoring part is installed, the capacitance value was set to 300, and the liquid passing through the flow channel of comparative example 1, example 2 and example 4 was repeated again, and the test results are as follows in table 2.
Table 2 table of results of passing the liquid of comparative example 1, example 2 and example 4 through the flow channel
As can be seen from table 2 above, when the capacitance is set to 300, different liquids are added respectively and sequentially flow through the flow channels; when the capacitance value is below 300, the front end continuously enters liquid, and when the capacitance value is above 300, the liquid feeding of the instrument is stopped. The results show that the method can effectively control the running and stopping of different liquids in the flow channel.
Example 5: the real-time monitoring method specifically comprises the following steps:
(1) an optical monitoring component is arranged on a flow passage of the detection instrument,
(2) the detection instrument obtains parameters of the liquid flowing through the flow passage through the feedback of the optical monitoring part;
an optical fiber probe is arranged on one side of the flow channel to emit 495nm light for excitation, and an optical filter is arranged on the other side of the flow channel to receive 520nm emitted light; the filter paper processed by SYBR GREEN or FITC fluorescent substance is arranged at the front end of the flow channel and serves as the filter structure, when liquid flows through the filter structure, the filter structure carries the fluorescent substance to pass through the monitoring component, and after the liquid is irradiated by exciting light, the filter paper can generate 520nm fluorescence which is monitored by the receiving probe, so that the situation that the liquid flows through the flow channel is judged, and the concentration of the fluorescent substance in the flowing liquid can be judged; the width of the flow channel is 3mm, the thickness of the flow channel is 2mm, and the size of the filter paper is 3mm x 2mm x 1mm, and the filter paper is placed at the front end of the flow channel; the filter paper is made of glass fiber paper, and is soaked in goat anti-mouse IgG antibody combined with FITC fluorescent substance for 8 hours at the concentration of 1mg/ml and then dried.
The detection substance is a mouse IgG antibody; when the mouse IgG antibody passes through the filter paper, the mouse IgG antibody can be combined with the goat anti-mouse IgG labeled by FITC on the filter paper, and enters the flow channel, and the concentration of a detection substance in the flow channel can be judged by detection; even a standard curve can be prepared to detect the substance concentration value.
Comparative example 2 and examples 6 to 8 were monitored by the methods and parameters described above, except that the concentrations of the detection substances were different, i.e., different concentrations of the murine IgG antibody; the results of the detection of the murine IgG antibodies at different concentrations are shown in table 3 below.
TABLE 3 detection results of murine IgG antibodies at different concentrations
As can be seen from table 3 above, as the concentration of the passing liquid increases, the detection value increases; therefore, whether the liquid flows through the flow passage and the level of the concentration of the liquid passing through the flow passage can be monitored in real time by the optical monitoring member.
Example 9: the real-time monitoring method specifically comprises the following steps:
(1) an acoustic monitoring part is arranged on a flow passage of the detection instrument,
(2) the detection instrument obtains parameters of the liquid flowing through the flow passage through the feedback of the acoustic monitoring part;
arranging a probe at one side of the flow channel for ultrasonic emission and receiving reflected sound waves; or a probe is arranged on one side of the flow channel for transmitting ultrasonic waves, and reflected sound waves are received on the other side of the flow channel; thereby judging the difference of the liquid in the flow passage; when liquid flows through the liquid level sensor, the transmission speed of sound waves is increased, the receiving time is shortened, and liquid level detection is carried out according to the transmission speed. The diameter of the probe is 1-3mm, and the ultrasonic frequency is 10MHZ-50 MHZ. Examples 9 to 11 and comparative example 3 differ from examples 1 to 2, 4 and comparative example 1 in the choice of monitoring means, and the results of the flow channel tests carried out on the different liquids, examples 9 to 11 and comparative example 3, are given in table 4 below.
TABLE 4 test results of examples 9 to 11 and comparative example 3 in which different liquids were circulated
As can be seen from the above table 4, when liquid flows through, the transmission speed of sound waves is increased, the receiving time is shortened, so that liquid level detection can be performed, and whether a liquid flow channel exists or not can be determined.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are only illustrative of the principles of the present invention, but that various changes and modifications, such as the size of the flow channel, or the size of the probe, etc., may be made without departing from the spirit and scope of the present invention, and these changes and modifications are within the scope of the claimed invention. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (10)
1. A real-time monitoring method is characterized by comprising the following steps:
(1) installing an electric monitoring component or/and an optical monitoring component or/and an acoustic monitoring component on a flow channel of the detection device;
(2) the detection instrument obtains the parameters of the liquid flowing through the flow passage through the feedback of the electric monitoring part or/and the optical monitoring part or/and the acoustic monitoring part.
2. The real-time monitoring method according to claim 1, wherein when the electrical monitoring component is adopted in the step (1), the specific steps are as follows: and electrode plates are respectively arranged on two sides of the flow channel, are respectively contacted with a probe of the detection instrument and are used for testing capacitance values or current or voltage when different liquids circulate, so that the flow channel for the different liquids is monitored and controlled through the capacitance values or the voltage or the current or the resistance.
3. The real-time monitoring method according to claim 2, wherein the diameter width of the flow channel is 1-10 mm, and the distance between the electrode plates or the resistors is 5-500 mm.
4. The real-time monitoring method according to claim 1, wherein when the optical monitoring component is used in the step (1), the specific steps are as follows: one side of the flow channel is provided with a transmitting light probe for excitation, and the other side is provided with a receiving probe for reading an absorbance value or a fluorescence value; or the emitting light probe is arranged on one side of the flow channel for excitation, and the receiving probe is arranged for reading the light absorption value or the fluorescence value.
5. The real-time monitoring method as claimed in claim 4, wherein when the optical monitoring component is used in step (1), a filter structure is further disposed at the front end of the flow channel, and the filter structure is treated with a fluorescent substance.
6. The real-time monitoring method according to claim 5, wherein when the optical monitoring component is used in the step (1), the specific steps are as follows:
s11, arranging light excitation emitted by the fiber probe on one side of the flow channel, and arranging emitted light received by the optical filter on the other side; or one side of the flow channel is provided with a transmitting light probe for excitation and a receiving probe for reading a light absorption value or a fluorescence value;
s12, arranging filter paper processed by fluorescent material at the front end of the flow channel as the filter structure, or adding fluorescent material at the front end of the flow channel, when liquid flows through, the filter paper carries the fluorescent material to pass through the monitoring component, after the liquid is irradiated by exciting light, fluorescence is generated and is monitored by the receiving probe, thereby judging that liquid flows through the flow channel, and judging the concentration of the fluorescent material in the flowing liquid.
7. The real-time monitoring method according to claim 1, wherein when the acoustic monitoring component is adopted in the step (1), the specific steps are as follows: arranging a probe at one side of the flow channel for ultrasonic emission and receiving reflected sound waves; or a probe is arranged on one side of the flow channel for transmitting ultrasonic waves, and reflected sound waves are received on the other side of the flow channel; thereby judging the difference of the liquid in the flow passage; when liquid flows through the liquid level sensor, the transmission speed of sound waves is increased, the receiving time is shortened, and liquid level detection is carried out according to the transmission speed.
8. The method of real-time monitoring according to claim 6, wherein the flow channel has a width of 3mm and a thickness of 2mm, and the filter paper has a size of 3mm x 2mm x 1mm and is placed at the front end of the flow channel.
9. The real-time monitoring method according to claim 8, wherein the filter paper is made of glass fiber paper, and the filter paper is soaked in the fluorescent substance-bound antibody at a concentration of 1-10 mg/ml for at least 8h and then dried.
10. The real-time monitoring method according to claim 7, wherein the diameter of the probe is 0.5-10 mm, and the ultrasonic frequency is 10-500 MHZ.
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| CN201910391123.5A CN111999511A (en) | 2019-05-11 | 2019-05-11 | Real-time monitoring method |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101441188A (en) * | 2008-12-23 | 2009-05-27 | 重庆大学 | Side wall type non-contact conductance detection system for micro-fluid control chip |
| CN203053499U (en) * | 2013-02-05 | 2013-07-10 | 刘健 | Time-difference method ultrasonic flowmeter |
| CN103191791A (en) * | 2013-03-01 | 2013-07-10 | 东南大学 | Integrated chip system for high-throughput sorting and counting detection of biological particles, and application |
| CN104422780A (en) * | 2013-08-28 | 2015-03-18 | 中国科学院大连化学物理研究所 | Rapid protein analysis and detection device based on whole microfluidic chip closing system |
| CN106442962A (en) * | 2016-09-12 | 2017-02-22 | 北京纳迅科技股份有限公司 | POCT instant detection device |
| CN108444896A (en) * | 2018-01-10 | 2018-08-24 | 深圳先进技术研究院 | A kind of optoacoustic detection device |
-
2019
- 2019-05-11 CN CN201910391123.5A patent/CN111999511A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101441188A (en) * | 2008-12-23 | 2009-05-27 | 重庆大学 | Side wall type non-contact conductance detection system for micro-fluid control chip |
| CN203053499U (en) * | 2013-02-05 | 2013-07-10 | 刘健 | Time-difference method ultrasonic flowmeter |
| CN103191791A (en) * | 2013-03-01 | 2013-07-10 | 东南大学 | Integrated chip system for high-throughput sorting and counting detection of biological particles, and application |
| CN104422780A (en) * | 2013-08-28 | 2015-03-18 | 中国科学院大连化学物理研究所 | Rapid protein analysis and detection device based on whole microfluidic chip closing system |
| CN106442962A (en) * | 2016-09-12 | 2017-02-22 | 北京纳迅科技股份有限公司 | POCT instant detection device |
| CN108444896A (en) * | 2018-01-10 | 2018-08-24 | 深圳先进技术研究院 | A kind of optoacoustic detection device |
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Application publication date: 20201127 |