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CN111920730A - A kind of repair moisturizing cream and preparation method thereof - Google Patents

A kind of repair moisturizing cream and preparation method thereof Download PDF

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Publication number
CN111920730A
CN111920730A CN202010785976.XA CN202010785976A CN111920730A CN 111920730 A CN111920730 A CN 111920730A CN 202010785976 A CN202010785976 A CN 202010785976A CN 111920730 A CN111920730 A CN 111920730A
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extract
skin
moisturizing cream
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repairing
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赖建雄
单仕勇
徐碧珊
罗淑文
林锦雄
朱伟海
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Guangzhou Fruit Shell Cosmetics Co ltd
Guangzhou Aibei Biological Technology Co Ltd
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Guangzhou Fruit Shell Cosmetics Co ltd
Guangzhou Aibei Biological Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/675Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • A61K8/735Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
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    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/02Preparations for care of the skin for chemically bleaching or whitening the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

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Abstract

本发明公开了一种修复保湿霜,包括以下组分:0.01~70%保湿剂、0.1~5%吸附剂、0.1~8%增稠剂、0.1~23%润肤剂、0.01~0.8%螯合剂、0.1~5%抗氧化剂、0.1~6%乳化剂、0.1~2%pH调节剂、0.1~90%皮肤调理剂和余量水。该产品在各组分协同配合下,在用于人体皮肤时可有效提升肌肤屏障修护力,同时紧致皮肤,收缩毛孔,提升皮肤弹力。该修复保湿霜中富含天然植物和微生物提取物作为皮肤调理剂,在使用时皮肤易吸收,可有效避免毛孔堵塞,同时各天然成分还可有效修复皮肤黑色素沉淀、粉刺等问题,提升皮肤抗菌和抗氧化能力,对皮肤也具有修复和促进愈合的功效。本发明还公开了所述修复保湿霜的制备方法,该制备方法操作简单,可工业化大批量生产。本发明还公开了一种皮肤调理组合物及其应用。The invention discloses a repairing moisturizing cream, comprising the following components: 0.01-70% moisturizing agent, 0.1-5% adsorbent, 0.1-8% thickening agent, 0.1-23% emollient, 0.01-0.8% chelating agent Mixture, 0.1-5% antioxidant, 0.1-6% emulsifier, 0.1-2% pH adjuster, 0.1-90% skin conditioner and balance water. With the synergistic cooperation of various components, the product can effectively improve the skin barrier repair power when used on human skin, while tightening the skin, shrinking pores, and improving skin elasticity. The repairing moisturizing cream is rich in natural plant and microbial extracts as skin conditioning agents, which are easily absorbed by the skin when used, which can effectively avoid clogging of pores. and anti-oxidant ability, it also has the effect of repairing and promoting healing on the skin. The invention also discloses a preparation method of the repairing moisturizing cream. The preparation method is simple to operate and can be industrially mass-produced. The invention also discloses a skin conditioning composition and its application.

Description

一种修复保湿霜及其制备方法A kind of repair moisturizing cream and preparation method thereof

技术领域technical field

本发明涉及化妆品技术领域,具体涉及一种修复保湿霜及其制备方法。The invention relates to the technical field of cosmetics, in particular to a repairing moisturizing cream and a preparation method thereof.

背景技术Background technique

皮肤组织细胞水分容易流失,水分缺失会导致皮肤干枯干裂,皮质疏松,皮肤毛孔粗大无弹性等,长期缺水还会对皮肤造成一定的损伤。因此,保湿产品一直是护肤品热门产品。与单纯的补水型化妆品相比,保湿产品特别是保湿霜产品其含水量高且可以均匀渗入皮肤内部,可有效舒缓皮肤干燥细纹及补充皮肤滋润水分,更适合在干燥季节使用。Skin tissue cells are prone to loss of water, and lack of water will lead to dry and cracked skin, loose cortex, large and inelastic skin pores, etc. Long-term lack of water will also cause certain damage to the skin. Therefore, moisturizing products have always been popular products in skin care products. Compared with pure moisturizing cosmetics, moisturizing products, especially moisturizing cream products, have high water content and can penetrate into the skin evenly, which can effectively relieve dry skin and fine lines and replenish skin moisture. It is more suitable for use in dry seasons.

然而,现有的保湿霜一般只具备保湿功能,作用单一,且大部分会添加防腐剂、香精等成分,天然植物成分含量少。此外,对于因干燥而造成的皮肤皱纹无法实现修复,作用有限。However, the existing moisturizing creams generally only have the moisturizing function with a single function, and most of them will add ingredients such as preservatives and flavors, and the content of natural plant ingredients is small. In addition, it cannot repair the skin wrinkles caused by dryness, and the effect is limited.

发明内容SUMMARY OF THE INVENTION

基于现有技术的不足,本发明的目的在于提供了一种修复保湿霜,该产品可有效舒缓肌肤,提升肌肤屏障修护力,紧致皮肤。Based on the deficiencies of the prior art, the purpose of the present invention is to provide a repairing moisturizing cream, which can effectively soothe the skin, improve the skin barrier repairing power, and firm the skin.

为了达到上述目的,本发明采取的技术方案为:In order to achieve the above object, the technical scheme adopted in the present invention is:

一种修复保湿霜,包括以下重量百分比的组分:0.01~70%保湿剂、0.1~5%吸附剂、0.1~8%增稠剂、0.1~23%润肤剂、0.01~0.8%螯合剂、0.1~5%抗氧化剂、0.1~6%乳化剂、0.1~2%pH调节剂、0.1~90%皮肤调理剂和余量水;所述皮肤调理剂包括占所述修复保湿霜的原料组分重量百分比0.1~0.8%的尿囊素、0.1~3%的羟苯基丙酰胺苯甲酸、0.1~2%的石榴皮(PUNICA GRANATUM)提取物、1~20%的仙桃仙人掌(OPUNTIA FICUS-INDICA)茎提取物、1~20%的库拉索芦荟(ALOE BARBADENSIS)叶汁、1~15%的药用层孔菌(FOMES OFFICINALIS)提取物、1~20%的积雪草(CENTELLA ASIATICA)提取物、1~8%的烟酰胺、0.1~12%的透明质酸钠混合物和1~20%的海茴香(CRITHMUM MARITIMUM)提取物;所述透明质酸钠混合物包括透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠的至少一种。A repairing moisturizing cream, comprising the following components by weight: 0.01-70% moisturizing agent, 0.1-5% adsorbent, 0.1-8% thickening agent, 0.1-23% emollient, 0.01-0.8% chelating agent , 0.1-5% antioxidant, 0.1-6% emulsifier, 0.1-2% pH adjuster, 0.1-90% skin conditioning agent and the balance of water; the skin conditioning agent comprises the raw material group of the repairing moisturizing cream 0.1-0.8% by weight of allantoin, 0.1-3% of hydroxyphenyl propanamide benzoic acid, 0.1-2% of pomegranate peel (PUNICA GRANATUM) extract, 1-20% of peach cactus (OPUNTIA FICUS- INDICA) stem extract, 1-20% of Aloe vera (ALOE BARBADENSIS) leaf juice, 1-15% of medicinal FOMES OFFICINALIS extract, 1-20% of Centella asiatica (CENTELLA ASIATICA) ) extract, 1-8% niacinamide, 0.1-12% sodium hyaluronate mixture and 1-20% sea fennel (CRITHMUM MARITIMUM) extract; the sodium hyaluronate mixture comprises sodium hyaluronate at least one of a copolymer, sodium hyaluronate, hydrolyzed sodium hyaluronate, and acetylated sodium hyaluronate.

所述皮肤调理剂中包含石榴皮提取物、仙桃仙人掌提取物、库拉索芦荟叶汁、积雪草提取物、海茴香提取物和药用层孔菌提取物。石榴皮提取物富含鞣花酸,该物质可有效抑制人体细胞中酪氨酸酶的活性,调理皮肤中的黑色素沉积,延缓皮肤衰老;仙桃仙人掌提取物具有抗菌作用,同时可抑制人体中雄性激素受体的活性,抑制人体皮肤表面因雄性激素高而引起的粉刺问题,保障皮肤表层健康;库拉索芦荟中富含多糖类、蒽醌类化合物、维生素和矿物质等有益成分,其叶片中的汁液用于人体皮肤时可起到收缩皮肤及解除皮肤硬化、角化的功效,同时对于皮肤上也有促进愈合及修复的作用,防止伤痕感染带来的皮肤炎症;积雪草提取物中的主要成分为积雪草甙和羟基积雪草苷。积雪草本身可作为药材食用,可用于湿热黄疸、痈肿疮毒和跌扑损伤等,当其提取物用于皮肤时可紧致表皮与真皮连接部分,使皮肤变柔软,有助于解决皮肤松弛现象;同时可帮助促进真皮层中胶原蛋白形成,使纤维蛋白再生,使肌肤达到紧致光滑的效果;还可帮助受损的皮肤组织愈合,起到消肿解毒祛脓疮的效果;海茴香作为一种沿海野生植物,其提取物富含茴香醚、α-茴香酮、甲基胡椒酚、茴香醛、维生素C等营养物质,能抑制亚油酸的过氧化作用,同时可抑制酪氨酸酶的活性,使用在人体皮肤上可有效美白皮肤,提高皮肤抗氧化性;所述药用层孔菌提取物主要萃取自生担菇-阿里红菌的浓缩活性物,在人体皮肤上使用能够解决皮肤油脂的过度分泌的问题,具有有收敛毛孔、保湿及平滑紧致肌肤的效果。发明经过筛选发现,使用上述天然植物和微生物提取物质按比例组合搭配代替传统化学产品用于保湿霜功效成分,不仅能避免化学品功效成分对皮肤的刺激性以及副作用,还可提供如改善皮肤粉刺等问题以及美白皮肤等普通保湿霜无法达到的有益效果。此外,所述皮肤调理剂中还含有烟酰胺、透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠;烟酰胺可用于防治糙皮病等皮肤缺陷,而透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠则具有防皱、抗皱、美容保健和恢复皮肤生理功能的作用,搭配上述植物和微生物提取物制备修复保湿霜可进一步提高其修复和提升皮肤的功效。The skin conditioning agent includes pomegranate peel extract, peach cactus extract, aloe vera leaf juice, centella asiatica extract, sea fennel extract and medicinal laminarum extract. Pomegranate peel extract is rich in ellagic acid, which can effectively inhibit the activity of tyrosinase in human cells, regulate melanin deposition in the skin, and delay skin aging. The activity of hormone receptors can inhibit the acne problems caused by high androgen on the human skin surface, and ensure the health of the skin surface; Aloe vera is rich in polysaccharides, anthraquinone compounds, vitamins and minerals and other beneficial ingredients, which When the juice in the leaves is used on human skin, it can shrink the skin and relieve skin sclerosis and keratinization. At the same time, it can also promote healing and repair on the skin, preventing skin inflammation caused by scar infection; Centella asiatica extract The main components in it are asiaticoside and madecassoside. Centella asiatica itself can be eaten as a medicinal material, and can be used for damp-heat jaundice, carbuncle sores and falls, etc. When its extract is used on the skin, it can tighten the connection between the epidermis and the dermis, make the skin soft, and help solve the problem. The phenomenon of skin relaxation; at the same time, it can help promote the formation of collagen in the dermis, regenerate fibrin, and make the skin firm and smooth; it can also help the damaged skin tissue heal, and has the effect of reducing swelling, detoxification, and abscesses; As a wild coastal plant, sea fennel extract is rich in anisole, α-anisone, methyl piperonol, anisaldehyde, vitamin C and other nutrients, which can inhibit the peroxidation of linoleic acid and inhibit the The activity of amino acid enzyme can effectively whiten the skin and improve the skin's anti-oxidation when used on human skin; the medicinal laminarum extract is mainly extracted from the concentrated active substance of the raw basidium mushroom - red fungus, and is used on human skin It can solve the problem of excessive secretion of skin oil, and has the effect of shrinking pores, moisturizing and smoothing and firming the skin. The invention has been screened and found that using the above-mentioned natural plant and microbial extracts in proportion to replace traditional chemical products for moisturizing cream functional ingredients can not only avoid the irritation and side effects of chemical functional ingredients on the skin, but also provide benefits such as improving skin acne. and other problems as well as beneficial effects that ordinary moisturizers such as skin whitening cannot achieve. In addition, the skin conditioner also contains nicotinamide, sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate and acetylated sodium hyaluronate; nicotinamide can be used to prevent and treat skin such as pellagra However, sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate and acetylated sodium hyaluronate have the functions of anti-wrinkle, anti-wrinkle, beauty care and restoration of skin physiological function. Restorative Moisturizers prepared with microbial extracts further enhance their efficacy in repairing and lifting the skin.

本发明所提供的修复保湿霜在各组分协同配合下,在用于人体皮肤时可有效提升肌肤屏障修护力,同时紧致皮肤,收缩毛孔,提升皮肤弹力。该修复保湿霜中富含天然植物和微生物提取物,在使用时皮肤易吸收,可有效避免毛孔堵塞,同时各天然成分还可有效修复皮肤黑色素沉淀、粉刺等问题,提升皮肤抗菌和抗氧化能力,保持皮肤水分的同时对皮肤也具有修复和促进愈合的功效,修复皮肤的屏障功能作用。本发明所制备的修复保湿霜皮肤适用性高,无刺激性和不良副反应。The repairing moisturizing cream provided by the present invention can effectively improve the skin barrier repairing power when applied to human skin with the synergistic cooperation of various components, and simultaneously tighten the skin, shrink pores and improve skin elasticity. The repair moisturizing cream is rich in natural plant and microbial extracts, which are easily absorbed by the skin when used, which can effectively avoid clogging of pores. At the same time, various natural ingredients can effectively repair skin melanin deposition, acne and other problems, and improve the skin's antibacterial and antioxidant capabilities. , while maintaining skin moisture, it also has the effect of repairing and promoting healing on the skin, and repairing the barrier function of the skin. The repairing moisturizing cream prepared by the invention has high skin applicability, no irritation and no adverse side reactions.

优选地,所述润肤剂包括占所述修复保湿霜的原料组分重量百分比0.1~8%的环五聚二甲基硅氧烷、0.1~6%的异壬酸异壬酯、0.1~3%的聚二甲基硅氧烷、0.1~3%的硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、0.1~3%的霍霍巴(SIMMONDSIA CHINENSIS)籽油和0.1~0.8%的辛酰羟肟酸。所述润肤剂中,霍霍巴籽油中的蜡酯分子排列和人的油脂类似,易于毛孔吸收,保持毛孔通畅;该物质富含维生素、矿物质和胶原蛋白等有益成分,在润滑肌肤的同时还可补充皮肤细胞所需营养物质。Preferably, the emollient comprises 0.1-8% by weight of the raw material components of the repair moisturizing cream, cyclopentasiloxane, 0.1-6% isononyl isononanoate, 0.1-6% 3% polydimethylsiloxane, 0.1-3% stearyloxypolymethicone/polydimethylsiloxane copolymer, 0.1-3% jojoba (SIMMONDSIA CHINENSIS) seed oil and 0.1-3% 0.8% octanoylhydroxamic acid. Among the emollients, the molecular arrangement of wax esters in jojoba seed oil is similar to that of human oil, which is easy for pores to be absorbed and keeps pores unobstructed; this substance is rich in beneficial ingredients such as vitamins, minerals and collagen, which can lubricate the skin. At the same time, it can also supplement the nutrients needed by skin cells.

优选地,所述保湿剂包括占所述修复保湿霜的原料组分重量百分比1~15%的甘油、1~20%的丁二醇、0.01~8%的甘油聚醚-26、1~5%的赤藓醇、0.1~6%的糖类同分异构体、0.1~3%的1,2-戊二醇、0.1~3%的1,2-己二醇和0.01~0.5%的乙基己基甘油。Preferably, the moisturizing agent comprises 1-15% of glycerin, 1-20% of butanediol, 0.01-8% of glycerol polyether-26, 1-5% by weight of the raw material components of the repairing moisturizing cream % erythritol, 0.1-6% saccharide isomers, 0.1-3% 1,2-pentanediol, 0.1-3% 1,2-hexanediol and 0.01-0.5% ethylene glycol Hexylglycerin.

优选地,所述吸附剂为占所述修复保湿霜的原料组分重量百分比0.1~5%的硅石。Preferably, the adsorbent is silica which accounts for 0.1-5% by weight of the raw material components of the repairing moisturizing cream.

优选地,所述增稠剂包括占所述修复保湿霜的原料组分重量百分比0.1~3%的丙烯酰二甲基牛磺酸铵/VP共聚物和0.1~3%的丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物。Preferably, the thickener comprises 0.1-3% by weight of the raw material components of the repairing moisturizing cream: ammonium acryloyldimethyltaurate/VP copolymer and 0.1-3% hydroxyethyl acrylate/ Sodium Acryloyldimethyltaurate Copolymer.

优选地,所述螯合剂包括占所述修复保湿霜的原料组分重量百分比0.01~0.1%的EDTA-二钠和0.1~0.8%的甘油辛酸酯。Preferably, the chelating agent comprises 0.01-0.1% of EDTA-disodium and 0.1-0.8% of glycerin caprylate by weight percentage of the raw material components of the repair moisturizing cream.

优选地,所述抗氧化剂包括占所述修复保湿霜的原料组分重量百分比0.1~3%的生育酚乙酸酯和0.1~2%的对羟基苯乙酮。Preferably, the antioxidant comprises 0.1-3% of tocopheryl acetate and 0.1-2% of p-hydroxyacetophenone by weight of the raw material components of the repair moisturizing cream.

优选地,所述乳化剂包括占所述修复保湿霜的原料组分重量百分比0.1~3%的鲸蜡硬脂醇橄榄油酸酯和0.1~3%的山梨坦橄榄油酸酯。Preferably, the emulsifier comprises 0.1-3% cetearyl oleate and 0.1-3% sorbitan oleate by weight of the raw material components of the repairing moisturizing cream.

优选地,所述pH调节剂为占所述修复保湿霜的原料组分重量百分比0.1~2%的精氨酸。Preferably, the pH adjusting agent is arginine in an amount of 0.1-2% by weight of the raw material components of the repairing moisturizing cream.

优选地,所述修复保湿霜包括以下重量百分比的组分:5%甘油、8%丁二醇、3%甘油聚醚-26、3%赤藓醇、2%糖类同分异构体、1%1,2-戊二醇、1%1,2-己二醇、0.1%乙基己基甘油、2%硅石、1%丙烯酰二甲基牛磺酸铵/VP共聚物、1%丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、0.05%EDTA-二钠、0.3%甘油辛酸酯、1%生育酚乙酸酯、0.5%对羟基苯乙酮、1%鲸蜡硬脂醇橄榄油酸酯、1%山梨坦橄榄油酸酯、0.5%精氨酸、3%环五聚二甲基硅氧烷、2%异壬酸异壬酯、1%聚二甲基硅氧烷、1%硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、1%霍霍巴籽油、0.3%辛酰羟肟酸、0.3%尿囊素、1%羟苯基丙酰胺苯甲酸、0.5%石榴皮提取物、8%仙桃仙人掌茎提取物、8%库拉索芦荟叶汁、5%药用层孔菌提取物、8%积雪草提取物、3%烟酰胺、5%透明质酸钠混合物、10%海茴香提取物和余量水。Preferably, the repairing moisturizing cream comprises the following components by weight: 5% glycerin, 8% butanediol, 3% glyceryl polyether-26, 3% erythritol, 2% sugar isomers, 1% 1,2-pentanediol, 1% 1,2-hexanediol, 0.1% ethylhexylglycerol, 2% silica, 1% ammonium acryloyldimethyltaurate/VP copolymer, 1% acrylic acid Hydroxyethyl ester/sodium acryloyldimethyltaurate copolymer, 0.05% EDTA-disodium, 0.3% glycerol caprylate, 1% tocopheryl acetate, 0.5% parahydroxyacetophenone, 1% cetyl wax Stearyl Olivate, 1% Sorbitan Olivate, 0.5% Arginine, 3% Cyclopentasiloxane, 2% Isononyl Iononanoate, 1% Dimethicone Silicone, 1% Stearyl Dimethicone/Dimethicone Copolymer, 1% Jojoba Seed Oil, 0.3% Caprylyl Hydroxamic Acid, 0.3% Allantoin, 1% Hydroxyphenyl Propionamide benzoic acid, 0.5% pomegranate peel extract, 8% prickly pear cactus stem extract, 8% curacao vera leaf juice, 5% medicinal layer of fungus extract, 8% centella asiatica extract, 3% tobacco amide, 5% sodium hyaluronate blend, 10% sea fennel extract and balance water.

本发明的另一目的还在于提供所述修复保湿霜的制备方法,所述制备方法为:Another object of the present invention also is to provide the preparation method of described repair moisturizing cream, described preparation method is:

将保湿剂和吸附剂加入水中,在80~100℃混合搅拌20~30min后,依次加入增稠剂、润肤剂、螯合剂、抗氧化剂和乳化剂后继续搅拌5~8min,并降温至40~50℃,加入pH调节剂和皮肤调理剂后搅拌混合均匀,即得所述修复保湿霜。Add the humectant and adsorbent to the water, mix and stir at 80-100°C for 20-30min, add thickener, emollient, chelating agent, antioxidant and emulsifier in turn, continue stirring for 5-8min, and cool down to 40°C. ~50°C, add pH adjuster and skin conditioner, stir and mix evenly to obtain the repairing moisturizing cream.

本发明所提供的修复保湿霜的制备方法操作简单,可工业化大批量生产。The preparation method of the repairing moisturizing cream provided by the invention is simple to operate, and can be mass-produced in an industrialized manner.

本发明的再一目的还在于提供一种皮肤调理组合物,包括以下重量份的组分:石榴皮提取物0.1~2份、仙桃仙人掌茎提取物1~20份、库拉索芦荟叶汁1~20份、药用层孔菌提取物1~15份、积雪草提取物1~20份、烟酰胺1~8份、透明质酸钠混合物0.1~12份和海茴香提取物1~20份,所述透明质酸钠混合物包括透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠;优选地,皮肤调理组合物包括以下重量份的组分:石榴皮提取物0.5份、仙桃仙人掌茎提取物8份、库拉索芦荟叶汁8份、药用层孔菌提取物5份、积雪草提取物8份、烟酰胺3份、透明质酸钠混合物5份和海茴香提取物10份。Another object of the present invention is to provide a skin conditioning composition, comprising the following components in parts by weight: 0.1-2 parts of pomegranate peel extract, 1-20 parts of prickly pear cactus stem extract, 1 part of aloe vera leaf juice ~20 parts, 1-15 parts of Phytoporus Medicinalis extract, 1-20 parts of Centella asiatica extract, 1-8 parts of niacinamide, 0.1-12 parts of sodium hyaluronate mixture, and 1-20 parts of sea fennel extract parts, the sodium hyaluronate mixture comprises sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate and acetylated sodium hyaluronate; preferably, the skin conditioning composition comprises the following parts by weight group Points: 0.5 parts of pomegranate peel extract, 8 parts of peach cactus stem extract, 8 parts of aloe vera leaf juice, 5 parts of medicinal Phytophthora extract, 8 parts of Centella asiatica extract, 3 parts of niacinamide, transparent 5 parts Sodium Hyaluronate Mixture and 10 parts Sea Fennel Extract.

优选地,所述皮肤调理组合物可用于化妆品,所述化妆品包括面膜液、精华液、护肤凝露、面霜和乳液中的至少一种。Preferably, the skin conditioning composition can be used in cosmetic products including at least one of facial mask lotions, serums, skin care gels, creams and lotions.

本发明的有益效果在于:本发明提供了一种修复保湿霜,该产品中各组分搭配协同,且富含石榴皮、仙桃仙人掌茎、库拉索芦荟、药用层孔菌、积雪草及海茴香等天然成分提取物作为皮肤调理剂,在用于人体皮肤时可有效提升肌肤屏障修护力,同时紧致皮肤,收缩毛孔,提升皮肤弹力。同时各天然成分还可有效修复皮肤黑色素沉淀、粉刺等问题,提升皮肤抗菌和抗氧化能力,可有效修复皮肤的屏障功能作用。本发明还提供了所述修复保湿霜的制备方法,该制备方法操作简单,可工业化大批量生产。本发明还提供了一种皮肤调理组合物及其应用。The beneficial effects of the present invention are as follows: the present invention provides a repairing moisturizing cream, the components in the product are coordinated and rich in pomegranate peel, prickly pear cactus stem, aloe vera, medicinal lamina, Centella asiatica And sea fennel and other natural ingredient extracts are used as skin conditioners. When used on human skin, it can effectively improve the skin barrier repair power, while tightening the skin, shrinking pores, and improving skin elasticity. At the same time, various natural ingredients can also effectively repair skin melanin deposition, acne and other problems, improve the skin's antibacterial and antioxidant capacity, and effectively repair the skin's barrier function. The invention also provides a preparation method of the repairing moisturizing cream, which is simple to operate and can be mass-produced in an industrialized manner. The present invention also provides a skin conditioning composition and application thereof.

具体实施方式Detailed ways

为了更好地说明本发明的目的、技术方案和优点,下面将结合具体实施例对本发明作进一步说明,其目的在于详细地理解本发明的内容,而不是对本发明的限制。In order to better illustrate the purpose, technical solutions and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments, the purpose of which is to understand the content of the present invention in detail, rather than limiting the present invention.

若无特别说明,下述具体实施例所用原料均为市购的普通商品,所述透明质酸钠混合物选用华熙生物科技股份有限公司的Hymagio-4D型号产品,0所述石榴皮(PUNICAGRANATUM)提取物选用上海晟薇生物科技有限公司的石榴皮提取物产品,所述仙桃仙人掌(OPUNTIA FICUS-INDICA)茎提取物选用广州瑞誉化工科技有限公司的的Jeju Cereus型号产品,所述库拉索芦荟(ALOE BARBADENSIS)叶汁选用广州千宇精细化工有限公司的芦荟提取物产品,所述药用层孔菌(FOMES OFFICINALIS)提取物选用佛山市新安化工贸易有限公司的Laricyl LS 8865型号产品、所述积雪草(CENTELLA ASIATICA)提取物选用广州汇朗生物科技有限公司的CentellaAsiatica Extract(HD)型号产品,所述海茴香(CRITHMUMMARITIMUM)提取物选用广州市百好博有限公司的PHYCOL CM型号产品。Unless otherwise specified, the raw materials used in the following specific examples are all commercially available common commodities, the sodium hyaluronate mixture is selected from the Hymagio-4D model product of Huaxi Biotechnology Co., Ltd., and the pomegranate peel (PUNICAGRANATUM) The extract selects the pomegranate peel extract product of Shanghai Shengwei Biotechnology Co., Ltd., and the stem extract of the Peach Cactus (OPUNTIA FICUS-INDICA) selects the Jeju Cereus model product of Guangzhou Ruiyu Chemical Technology Co., Ltd., and the Curacao Aloe vera (ALOE BARBADENSIS) leaf juice selects the aloe vera extract product of Guangzhou Qianyu Fine Chemical Co., Ltd., and the medicinal FOMES OFFICINALIS (FOMES OFFICINALIS) extract selects the Lricyl LS 8865 model product of Foshan Xin'an Chemical Trade Co., Ltd., The Centella Asiatica (CENTELLA Asiatica) extract is selected from the CentellaAsiatica Extract (HD) model product of Guangzhou Huilang Biotechnology Co., Ltd., and the CRITHMUMMARITIMUM extract is selected from the PHYCOL CM model product of Guangzhou Baihaobo Co., Ltd.

实施例1Example 1

本发明所述皮肤调理组合物的一种实施例,所述皮肤调理组合物包括以下重量份的组分:石榴皮提取物0.5份、仙桃仙人掌茎提取物8份、库拉索芦荟叶汁8份、药用层孔菌提取物5份、积雪草提取物8份、烟酰胺3份、透明质酸钠5份、水解透明质酸钠5份、透明质酸钠混合物5份和海茴香提取物10份;所述透明质酸钠混合物包括透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠。An embodiment of the skin conditioning composition of the present invention, the skin conditioning composition includes the following components in parts by weight: 0.5 parts of pomegranate peel extract, 8 parts of prickly pear cactus stem extract, 8 parts of aloe vera leaf juice 5 parts, 5 parts Medicinal Pyricularis Extract, 8 parts Centella Asiatica Extract, 3 parts Niacinamide, 5 parts Sodium Hyaluronate, 5 parts Hydrolyzed Sodium Hyaluronate, 5 parts Sodium Hyaluronate Mixture and Sea Fennel 10 parts of the extract; the sodium hyaluronate mixture includes sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate and acetylated sodium hyaluronate.

实施例2Example 2

本发明所述皮肤调理组合物的一种实施例,所述皮肤调理组合物包括以下重量份的组分:石榴皮提取物2份、仙桃仙人掌茎提取物5份、库拉索芦荟叶汁10份、药用层孔菌提取物15份、积雪草提取物5份、烟酰胺8份、透明质酸钠混合物5份和海茴香提取物20份;所述透明质酸钠混合物包括透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠。An embodiment of the skin conditioning composition of the present invention, the skin conditioning composition includes the following components in parts by weight: 2 parts of pomegranate peel extract, 5 parts of prickly pear cactus stem extract, 10 parts of aloe vera leaf juice parts, 15 parts of Phytoporus Medicinalis extract, 5 parts of Centella asiatica extract, 8 parts of niacinamide, 5 parts of sodium hyaluronate mixture and 20 parts of sea fennel extract; the sodium hyaluronate mixture includes hyaluronic acid Sodium Crosspolymer, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate and Acetylated Sodium Hyaluronate.

实施例3Example 3

本发明所述皮肤调理组合物的一种实施例,所述皮肤调理组合物包括以下重量份的组分:石榴皮提取物15份、仙桃仙人掌茎提取物15份、库拉索芦荟叶汁5份、药用层孔菌提取物5份、积雪草提取物20份、烟酰胺2份、透明质酸钠混合物5份和海茴香提取物5份;所述透明质酸钠混合物包括透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠。An embodiment of the skin conditioning composition of the present invention, the skin conditioning composition includes the following components by weight: 15 parts of pomegranate peel extract, 15 parts of prickly pear cactus stem extract, 5 parts of aloe vera leaf juice parts, 5 parts of Phytophthora Medicinalis extract, 20 parts of Centella asiatica extract, 2 parts of niacinamide, 5 parts of sodium hyaluronate mixture and 5 parts of sea fennel extract; the sodium hyaluronate mixture includes hyaluronic acid Sodium Crosspolymer, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate and Acetylated Sodium Hyaluronate.

以上实施例的皮肤调理组合物根据需要添加必要的基质组分,可以制备得到面膜液、精华液、护肤凝露、面霜、乳液等化妆品。The skin conditioning compositions of the above embodiments are added with necessary matrix components as required, and cosmetics such as facial mask liquid, essence, skin care gel, facial cream, and lotion can be prepared.

实施例4Example 4

本发明所述修复保湿霜的一种实施例,所述修复保湿霜包括以下组分:23.1%保湿剂、2%吸附剂、2%增稠剂、8.3%润肤剂、0.35%螯合剂、1.5%抗氧化剂、2%乳化剂、0.5%pH调节剂、48.8%皮肤调理剂和余量水。所述保湿剂包括占所述修复保湿霜的组分重量百分比5%甘油、8%丁二醇、3%甘油聚醚-26、3%赤藓醇、2%糖类同分异构体、1%1,2-戊二醇、1%1,2-己二醇和0.1%乙基己基甘油;所述吸附剂为占所述修复保湿霜的原料组分重量百分比2%的硅石;所述增稠剂包括占所述修复保湿霜的原料组分重量百分比1%丙烯酰二甲基牛磺酸铵/VP共聚物、1%丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物;所述螯合剂包括占所述修复保湿霜的原料组分重量百分比0.05%EDTA-二钠和0.3%甘油辛酸酯;所述抗氧化剂包括占所述修复保湿霜的原料组分重量百分比1%生育酚乙酸酯和0.5%对羟基苯乙酮;所述乳化剂包括占所述修复保湿霜的原料组分重量百分比1%鲸蜡硬脂醇橄榄油酸酯和1%山梨坦橄榄油酸酯;所述pH调节剂为占所述修复保湿霜的原料组分重量百分比0.5%的精氨酸;所述润肤剂包括占所述修复保湿霜的原料组分重量百分比3%环五聚二甲基硅氧烷、2%异壬酸异壬酯、1%聚二甲基硅氧烷、1%硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、1%霍霍巴籽油和0.3%辛酰羟肟酸;所述皮肤调理剂包括占所述修复保湿霜的原料组分百分比重量0.3%尿囊素、1%羟苯基丙酰胺苯甲酸、0.5%石榴皮提取物、8%仙桃仙人掌茎提取物、8%库拉索芦荟叶汁、5%药用层孔菌提取物、8%积雪草提取物、3%烟酰胺、5%透明质酸钠混合物和10%海茴香提取物。An embodiment of the repairing moisturizing cream of the present invention, the repairing moisturizing cream includes the following components: 23.1% moisturizing agent, 2% adsorbent, 2% thickening agent, 8.3% emollient, 0.35% chelating agent, 1.5% antioxidant, 2% emulsifier, 0.5% pH adjuster, 48.8% skin conditioner and balance water. The moisturizing agent comprises 5% glycerol, 8% butanediol, 3% glycerol polyether-26, 3% erythritol, 2% sugar isomer, 1% 1,2-pentanediol, 1% 1,2-hexanediol and 0.1% ethylhexylglycerol; the adsorbent is 2% by weight of the raw material components of the repair moisturizing cream silica; the Thickeners include 1% ammonium acryloyl dimethyl taurate/VP copolymer and 1% hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer in the weight percentage of the raw material components of the repair moisturizing cream ; The chelating agent comprises 0.05% EDTA-disodium and 0.3% glycerol caprylate in the weight percentage of the raw material components of the repair moisturizing cream; the antioxidant comprises 1 weight percentage of the raw material components in the repair moisturizing cream % tocopheryl acetate and 0.5% p-hydroxyacetophenone; the emulsifier comprises 1% cetearyl oliveate and 1% sorbitan olive oil in the weight percentage of the raw material components of the repair moisturizing cream acid ester; the pH adjuster is arginine accounting for 0.5% by weight of the raw material components of the repairing moisturizing cream; the emollient includes 3% cyclopenta Dimethicone, 2% isononyl isononanoate, 1% Dimethicone, 1% Stearyloxymethicone/Dimethicone Copolymer, 1% Hoho Seed oil and 0.3% capryloylhydroxamic acid; the skin conditioning agent comprises 0.3% allantoin, 1% hydroxyphenyl propanamide benzoic acid, 0.5% pomegranate peel by weight of the raw material components of the repair moisturizing cream Extract, 8% Prickly Pear Cactus Stem Extract, 8% Aloe Vera Leaf Juice, 5% Medicinal Pyricularia Extract, 8% Centella Asiatica Extract, 3% Niacinamide, 5% Sodium Hyaluronate Blend and 10% sea fennel extract.

实施例5Example 5

本发明所述修复保湿霜的一种实施例,所述修复保湿霜包括以下组分:23.1%保湿剂、2%吸附剂、2%增稠剂、8.3%润肤剂、0.35%螯合剂、1.5%抗氧化剂、2%乳化剂、0.5%pH调节剂、48.8%皮肤调理剂和余量水。所述保湿剂包括占所述修复保湿霜的组分重量百分比5%甘油、8%丁二醇、3%甘油聚醚-26、3%赤藓醇、2%糖类同分异构体、1%1,2-戊二醇、1%1,2-己二醇和0.1%乙基己基甘油;所述吸附剂为占所述修复保湿霜的原料组分重量百分比2%的硅石;所述增稠剂包括占所述修复保湿霜的原料组分重量百分比1%丙烯酰二甲基牛磺酸铵/VP共聚物、1%丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物;所述螯合剂包括占所述修复保湿霜的原料组分重量百分比0.05%EDTA-二钠和0.3%甘油辛酸酯;所述抗氧化剂包括占所述修复保湿霜的原料组分重量百分比1%生育酚乙酸酯和0.5%对羟基苯乙酮;所述乳化剂包括占所述修复保湿霜的原料组分重量百分比1%鲸蜡硬脂醇橄榄油酸酯和1%山梨坦橄榄油酸酯;所述pH调节剂为占所述修复保湿霜的原料组分重量百分比0.5%的精氨酸;所述润肤剂包括占所述修复保湿霜的原料组分重量百分比3%环五聚二甲基硅氧烷、2%异壬酸异壬酯、1%聚二甲基硅氧烷、1%硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、1%霍霍巴籽油和0.3%辛酰羟肟酸;所述皮肤调理剂包括占所述修复保湿霜的原料组分百分比重量0.1%尿囊素、3%羟苯基丙酰胺苯甲酸、0.1%石榴皮提取物、3%仙桃仙人掌茎提取物、15%库拉索芦荟叶汁、2%药用层孔菌提取物、3%积雪草提取物、3%烟酰胺、10%透明质酸钠混合物和9.6%海茴香提取物。An embodiment of the repairing moisturizing cream of the present invention, the repairing moisturizing cream includes the following components: 23.1% moisturizing agent, 2% adsorbent, 2% thickening agent, 8.3% emollient, 0.35% chelating agent, 1.5% antioxidant, 2% emulsifier, 0.5% pH adjuster, 48.8% skin conditioner and balance water. The moisturizing agent comprises 5% glycerol, 8% butanediol, 3% glycerol polyether-26, 3% erythritol, 2% sugar isomer, 1% 1,2-pentanediol, 1% 1,2-hexanediol and 0.1% ethylhexylglycerol; the adsorbent is 2% by weight of the raw material components of the repair moisturizing cream silica; the Thickeners include 1% ammonium acryloyl dimethyl taurate/VP copolymer and 1% hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer in the weight percentage of the raw material components of the repair moisturizing cream ; The chelating agent comprises 0.05% EDTA-disodium and 0.3% glycerol caprylate in the weight percentage of the raw material components of the repair moisturizing cream; the antioxidant comprises 1 weight percentage of the raw material components in the repair moisturizing cream % tocopheryl acetate and 0.5% p-hydroxyacetophenone; the emulsifier comprises 1% cetearyl oliveate and 1% sorbitan olive oil in the weight percentage of the raw material components of the repair moisturizing cream acid ester; the pH adjuster is arginine accounting for 0.5% by weight of the raw material components of the repairing moisturizing cream; the emollient includes 3% cyclopenta Dimethicone, 2% isononyl isononanoate, 1% Dimethicone, 1% Stearyloxymethicone/Dimethicone Copolymer, 1% Hoho Seed oil and 0.3% capryloylhydroxamic acid; the skin conditioning agent includes 0.1% allantoin, 3% hydroxyphenyl propanamide benzoic acid, 0.1% pomegranate peel by weight of the raw material components of the repair moisturizing cream Extract, 3% Prickly Pear Cactus Stem Extract, 15% Aloe Barbadensis Leaf Juice, 2% Phytophthora Medicinalis Extract, 3% Centella Asiatica Extract, 3% Niacinamide, 10% Sodium Hyaluronate Blend and 9.6% sea fennel extract.

实施例6Example 6

本发明所述修复保湿霜的一种实施例,所述修复保湿霜包括以下组分:23.1%保湿剂、2%吸附剂、2%增稠剂、8.3%润肤剂、0.35%螯合剂、1.5%抗氧化剂、2%乳化剂、0.5%pH调节剂、48.8%皮肤调理剂和余量水。所述保湿剂包括占所述修复保湿霜的组分重量百分比5%甘油、8%丁二醇、3%甘油聚醚-26、3%赤藓醇、2%糖类同分异构体、1%1,2-戊二醇、1%1,2-己二醇和0.1%乙基己基甘油;所述吸附剂为占所述修复保湿霜的原料组分重量百分比2%的硅石;所述增稠剂包括占所述修复保湿霜的原料组分重量百分比1%丙烯酰二甲基牛磺酸铵/VP共聚物、1%丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物;所述螯合剂包括占所述修复保湿霜的原料组分重量百分比0.05%EDTA-二钠和0.3%甘油辛酸酯;所述抗氧化剂包括占所述修复保湿霜的原料组分重量百分比1%生育酚乙酸酯和0.5%对羟基苯乙酮;所述乳化剂包括占所述修复保湿霜的原料组分重量百分比1%鲸蜡硬脂醇橄榄油酸酯和1%山梨坦橄榄油酸酯;所述pH调节剂为占所述修复保湿霜的原料组分重量百分比0.5%的精氨酸;所述润肤剂包括占所述修复保湿霜的原料组分重量百分比0.1%环五聚二甲基硅氧烷、1%异壬酸异壬酯、2.7%聚二甲基硅氧烷、1%硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、3%霍霍巴籽油和0.5%辛酰羟肟酸;所述皮肤调理剂包括占所述修复保湿霜的原料组分百分比重量0.3%尿囊素、1%羟苯基丙酰胺苯甲酸、0.5%石榴皮提取物、8%仙桃仙人掌茎提取物、8%库拉索芦荟叶汁、5%药用层孔菌提取物、8%积雪草提取物、3%烟酰胺、5%透明质酸钠混合物和10%海茴香提取物。An embodiment of the repairing moisturizing cream of the present invention, the repairing moisturizing cream includes the following components: 23.1% moisturizing agent, 2% adsorbent, 2% thickening agent, 8.3% emollient, 0.35% chelating agent, 1.5% antioxidant, 2% emulsifier, 0.5% pH adjuster, 48.8% skin conditioner and balance water. The moisturizing agent comprises 5% glycerol, 8% butanediol, 3% glycerol polyether-26, 3% erythritol, 2% sugar isomer, 1% 1,2-pentanediol, 1% 1,2-hexanediol and 0.1% ethylhexylglycerol; the adsorbent is 2% by weight of the raw material components of the repair moisturizing cream silica; the Thickeners include 1% ammonium acryloyl dimethyl taurate/VP copolymer and 1% hydroxyethyl acrylate/sodium acryloyl dimethyl taurate copolymer in the weight percentage of the raw material components of the repair moisturizing cream ; The chelating agent comprises 0.05% EDTA-disodium and 0.3% glycerol caprylate in the weight percentage of the raw material components of the repair moisturizing cream; the antioxidant comprises 1 weight percentage of the raw material components in the repair moisturizing cream % tocopheryl acetate and 0.5% p-hydroxyacetophenone; the emulsifier comprises 1% cetearyl oliveate and 1% sorbitan olive oil in the weight percentage of the raw material components of the repair moisturizing cream acid ester; the pH adjuster is arginine accounting for 0.5% by weight of the raw material components of the repair moisturizing cream; the emollient includes 0.1% by weight of the raw material components of the repairing moisturizing cream Dimethicone, 1% Isononyl Iononanoate, 2.7% Dimethicone, 1% Stearyl Dimethicone/Dimethicone Copolymer, 3% Hoho Seed oil and 0.5% capryloylhydroxamic acid; the skin conditioning agent comprises 0.3% allantoin, 1% hydroxyphenyl propanamide benzoic acid, 0.5% pomegranate peel by weight of the raw material components of the repair moisturizing cream Extract, 8% Prickly Pear Cactus Stem Extract, 8% Aloe Vera Leaf Juice, 5% Medicinal Pyricularia Extract, 8% Centella Asiatica Extract, 3% Niacinamide, 5% Sodium Hyaluronate Blend and 10% sea fennel extract.

实施例7Example 7

本发明所述修复保湿霜的一种实施例,所述修复保湿霜包括以下组分:23.1%保湿剂、5%吸附剂、2%增稠剂、8.6%润肤剂、0.35%螯合剂、1.5%抗氧化剂、2%乳化剂、0.5%pH调节剂、48.8%皮肤调理剂和余量水。所述保湿剂包括占所述修复保湿霜的组分重量百分比1%甘油、1%丁二醇、8%甘油聚醚-26、5%赤藓醇、6%糖类同分异构体、1%1,2-戊二醇、1%1,2-己二醇和0.1%乙基己基甘油;所述吸附剂为占所述修复保湿霜的原料组分重量百分比5%的硅石;所述增稠剂包括占所述修复保湿霜的原料组分重量百分比0.1%丙烯酰二甲基牛磺酸铵/VP共聚物、1.9%丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物;所述螯合剂包括占所述修复保湿霜的原料组分重量百分比0.05%EDTA-二钠和0.3%甘油辛酸酯;所述抗氧化剂包括占所述修复保湿霜的原料组分重量百分比1%生育酚乙酸酯和0.5%对羟基苯乙酮;所述乳化剂包括占所述修复保湿霜的原料组分重量百分比1%鲸蜡硬脂醇橄榄油酸酯和1%山梨坦橄榄油酸酯;所述pH调节剂为占所述修复保湿霜的原料组分重量百分比0.5%的精氨酸;所述润肤剂包括占所述修复保湿霜的原料组分重量百分比0.1%环五聚二甲基硅氧烷、1%异壬酸异壬酯、3%聚二甲基硅氧烷、1%硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、3%霍霍巴籽油和0.5%辛酰羟肟酸;所述皮肤调理剂包括占所述修复保湿霜的原料组分百分比重量0.3%尿囊素、1%羟苯基丙酰胺苯甲酸、0.5%石榴皮提取物、8%仙桃仙人掌茎提取物、8%库拉索芦荟叶汁、5%药用层孔菌提取物、8%积雪草提取物、3%烟酰胺、5%透明质酸钠混合物和10%海茴香提取物。An embodiment of the repair moisturizing cream of the present invention, the repairing moisturizing cream includes the following components: 23.1% moisturizing agent, 5% adsorbent, 2% thickening agent, 8.6% emollient, 0.35% chelating agent, 1.5% antioxidant, 2% emulsifier, 0.5% pH adjuster, 48.8% skin conditioner and balance water. The moisturizing agent comprises 1% glycerol, 1% butanediol, 8% glycerol polyether-26, 5% erythritol, 6% sugar isomer, 1% 1,2-pentanediol, 1% 1,2-hexanediol and 0.1% ethylhexylglycerol; the adsorbent is 5% by weight of the raw material components of the repair moisturizing cream; the Thickeners include 0.1% ammonium acryloyldimethyltaurate/VP copolymer and 1.9% hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer in weight percentage of the raw material components of the repair moisturizing cream ; The chelating agent comprises 0.05% EDTA-disodium and 0.3% glycerol caprylate in the weight percentage of the raw material components of the repair moisturizing cream; the antioxidant comprises 1 weight percentage of the raw material components in the repair moisturizing cream % tocopheryl acetate and 0.5% p-hydroxyacetophenone; the emulsifier comprises 1% cetearyl oliveate and 1% sorbitan olive oil in the weight percentage of the raw material components of the repair moisturizing cream acid ester; the pH adjuster is arginine accounting for 0.5% by weight of the raw material components of the repair moisturizing cream; the emollient includes 0.1% by weight of the raw material components of the repairing moisturizing cream Dimethicone, 1% Isononyl Iononanoate, 3% Dimethicone, 1% Stearyl Dimethicone/Dimethicone Copolymer, 3% Hoho Seed oil and 0.5% capryloylhydroxamic acid; the skin conditioning agent comprises 0.3% allantoin, 1% hydroxyphenyl propanamide benzoic acid, 0.5% pomegranate peel by weight of the raw material components of the repair moisturizing cream Extract, 8% Prickly Pear Cactus Stem Extract, 8% Aloe Vera Leaf Juice, 5% Medicinal Pyricularia Extract, 8% Centella Asiatica Extract, 3% Niacinamide, 5% Sodium Hyaluronate Blend and 10% sea fennel extract.

对比例1Comparative Example 1

本对比例与实施例4的区别在于,本对比例中所述修复保湿霜的原料组分不含皮肤调理剂。The difference between this comparative example and Example 4 is that the raw material components of the repairing moisturizing cream described in this comparative example do not contain skin conditioning agents.

对比例2Comparative Example 2

本对比例与对比例与实施例4的区别在于,本对比例中所述皮肤调理剂中不含石榴皮提取物。The difference between the present comparative example and the comparative example and Example 4 is that the skin conditioner in the present comparative example does not contain pomegranate peel extract.

对比例3Comparative Example 3

本对比例与对比例与实施例4的区别在于,本对比例中所述皮肤调理剂中不含仙桃仙人掌茎提取物。The difference between the present comparative example and the comparative example and Example 4 is that the skin conditioning agent in the present comparative example does not contain the Prickly Pear cactus stem extract.

对比例4Comparative Example 4

本对比例与对比例与实施例4的区别在于,本对比例中所述皮肤调理剂中不含库拉索芦荟叶汁。The difference between the present comparative example and the comparative example and Example 4 is that the skin conditioning agent in the present comparative example does not contain aloe vera leaf juice.

对比例5Comparative Example 5

本对比例与对比例与实施例4的区别在于,本对比例中所述皮肤调理剂中不含药用层孔菌提取物。The difference between the present comparative example and the comparative example and Example 4 is that the skin conditioning agent in the present comparative example does not contain the extract of Laminaria Medicinalae.

对比例6Comparative Example 6

本对比例与对比例与实施例4的区别在于,本对比例中所述皮肤调理剂中不含积雪草提取物。The difference between the present comparative example and the comparative example and Example 4 is that the skin conditioner in the present comparative example does not contain Centella asiatica extract.

对比例7Comparative Example 7

本对比例与对比例与实施例4的区别在于,本对比例中所述皮肤调理剂中不含透明质酸钠混合物。The difference between this comparative example and the comparative example and Example 4 is that the skin conditioner in this comparative example does not contain a mixture of sodium hyaluronate.

对比例8Comparative Example 8

本对比例与对比例与实施例4的区别在于,本对比例中所述皮肤调理剂中不含海茴香提取物The difference between the present comparative example and the comparative example and Example 4 is that the skin conditioner in the present comparative example does not contain sea fennel extract

实施例8Example 8

为了验证实施例4~7和对比例1~8所述修复保湿霜安全性,进行致敏性实验评价,测试方法如下:In order to verify the safety of the repairing moisturizing creams described in Examples 4-7 and Comparative Examples 1-8, an experimental evaluation of sensitization was carried out, and the test method was as follows:

受试人群Subject population

性别数目:女性10人Number of genders: 10 females

年龄:30~45岁之间Age: Between 30 and 45 years old

健康状况:受试者皮肤健康,无皮肤病过敏史,符合受试者志愿入选标准。Health status: The subjects have healthy skin, no history of skin allergies, and meet the volunteer selection criteria of the subjects.

2.试验部位:上背部脊柱两侧的正常皮肤。2. Test site: normal skin on both sides of the upper back spine.

3.测试步骤:3. Test steps:

(1)去除斑试器的保护纸、将准备好的变应原按顺序置于铝制斑试器内。斑试物排练顺序为自上往下,自左往右并做标记。将实施例4~7和对比例1~8所制备的产品取25uL直接放入斑试器中,用25uL甲醛滴在放入斑试器中的滤纸片上。(1) Remove the protective paper of the spot tester, and place the prepared allergens in the aluminum spot tester in sequence. The rehearsal sequence of the test specimens is from top to bottom, from left to right and marked. 25uL of the products prepared in Examples 4 to 7 and Comparative Examples 1 to 8 were directly put into the plaque tester, and 25uL of formaldehyde was dropped on the filter paper put in the plaque tester.

(2)将加有斑试物的斑试器胶带自下向上贴牢、贴平并用手掌轻轻压几下,以排出空气。(2) Stick the patch tester tape with the patch test substance from bottom to top, stick it flat, and press it gently with the palm of your hand for a few times to exhaust the air.

(3)贴敷48h后,去除斑试器,静置30分钟后观察结果。(3) After 48 hours of application, remove the spot tester, and observe the results after standing for 30 minutes.

评价方法为:The evaluation method is:

(-)阴性:敷贴部位无反应,或仅胶布贴着处发红,中央反而不红。(-) Negative: There is no reaction at the application site, or only the place where the tape is attached is red, but the center is not red.

(±)可疑:试验部位痒或仅有微弱的(不清楚的)红斑。(±) Suspicious: itching or only faint (indistinct) erythema at the test site.

(+)弱阳性:红斑、浸润、丘疹、小水疱。(+) Weakly positive: erythema, infiltrates, papules, small blisters.

(++)中阳性:散在丘疹,瘙痒明显。(++) Medium positive: scattered papules with obvious itching.

(+++)强阳性:红肿并有大疱。(+++) Strong positive: redness and swelling with bullae.

测试结果如表1所示。The test results are shown in Table 1.

表1Table 1

Figure BDA0002621261430000111
Figure BDA0002621261430000111

Figure BDA0002621261430000121
Figure BDA0002621261430000121

从表1的结果可见,本发明实施例4~7制备的修复保湿霜和对比例1~8的保湿霜产品均对皮肤温和,无刺激,使用安全。It can be seen from the results in Table 1 that the repairing moisturizing creams prepared in Examples 4-7 of the present invention and the moisturizing cream products of Comparative Examples 1-8 are both mild to the skin, non-irritating, and safe to use.

实施例9Example 9

为了验证本发明所述修复保湿霜的祛皱和滋润,将实施例4制备得到的修复保湿霜进行如下皮肤弹性测试:In order to verify the wrinkle removal and moisturizing of the repairing moisturizing cream of the present invention, the repairing moisturizing cream prepared in Example 4 was subjected to the following skin elasticity test:

1、受试人群1. Subject population

性别数目:女性10人Number of genders: 10 females

年龄:30~45岁之间Age: Between 30 and 45 years old

健康状况:受试者皮肤健康,无皮肤病过敏史,符合受试者志愿入选标准。Health status: The subjects have healthy skin, no history of skin allergies, and meet the volunteer selection criteria of the subjects.

2.测试方法:采用德国Courage+Khazaka公司(德国CK公司)制造的皮肤弹性CotometerMPA580主机,所使用的探头是Reviscometer RV600弹性纤维组织测试探头,测五次取平均值。2. Test method: The skin elasticity Cotometer MPA580 main unit manufactured by Germany Courage+Khazaka Company (Germany CK Company) is used, and the probe used is Reviscometer RV600 elastic fiber tissue test probe, and the average value is obtained by measuring five times.

测试区域:眉心正中间往上2cm额头区域、下嘴唇正中间往下2cm下巴区域、鼻尖与瞳孔交线处左、右脸颊区域。先测量被测试区域清洁后30min的空白值(R2、R5、R7),然后规定受试者每天早晚坚持使用上述试验品,分别测试1周、2周、3周、4周后测试区域皮肤弹性指数R2、R5、R7值(测试过程中负压恒定为450mbar)。Test area: the forehead area 2cm above the center of the eyebrows, the chin area 2cm below the middle of the lower lip, the left and right cheek areas at the intersection of the nose tip and the pupil. First measure the blank value (R2, R5, R7) of the tested area 30 minutes after cleaning, and then stipulate that the subjects insist on using the above test products every morning and evening, and test the skin elasticity of the test area after 1 week, 2 weeks, 3 weeks, and 4 weeks respectively. Index R2, R5, R7 values (the negative pressure is constant at 450mbar during the test).

3.指标说明:皮肤弹性指数R2、R5和R7,指数越接近1,皮肤的弹性越好。其中R2=Ua/Uf;R5=Ur/Ue;R7=Ur/Uf;Uf为皮肤最大拉伸量;Ue为恒定负压加到皮肤上后,0.1s时皮肤的拉伸量,定位弹性部分拉伸量;Ur为取消负压后,皮肤就会迅速恢复原状态,同样分为弹性部分值Ur,即取消负压0.1s后,皮肤的恢复值和粘弹性部分值,或称塑性部分值;Ua为从取消负压到下一次连续测试皮肤表面再加负压时皮肤的恢复值。3. Indicator description: skin elasticity index R2, R5 and R7, the closer the index is to 1, the better the elasticity of the skin. R2=Ua/Uf; R5=Ur/Ue; R7=Ur/Uf; Uf is the maximum stretching amount of the skin; Ue is the stretching amount of the skin at 0.1s after constant negative pressure is applied to the skin, positioning the elastic part The amount of stretching; Ur is the skin will quickly return to its original state after the negative pressure is cancelled, and it is also divided into the elastic part value Ur, that is, after the negative pressure is cancelled for 0.1s, the recovery value and the viscoelastic part value of the skin, or the plastic part value ; Ua is the recovery value of the skin from the cancellation of the negative pressure to the next time the negative pressure is added to the skin surface for the next continuous test.

测试结果见表2。The test results are shown in Table 2.

表2Table 2

测试周期test period R2R2 R5R5 R7R7 00 0.45320.4532 0.44310.4431 0.42860.4286 11 0.60410.6041 0.53360.5336 0.49130.4913 22 0.75820.7582 0.67350.6735 0.62480.6248 33 0.85650.8565 0.77630.7763 0.71320.7132 44 0.90820.9082 0.85180.8518 0.80880.8088

由表2的测试可知,使用实施例4的修复保湿面霜第一周后R2、R5、R7已经有所增加,第4周R2、R5、R7均上升明显,R2、R5、R7值趋近于1,受试者的皮肤弹性指数有非常大的提升。由此可见,本发明所述紧致修复保湿霜具有明显增加皮肤弹性、祛皱的功效。It can be seen from the test in Table 2 that R2, R5, and R7 have increased after the first week of using the repair moisturizing cream of Example 4, and in the fourth week, R2, R5, and R7 have all increased significantly, and the values of R2, R5, and R7 are close to 1. The skin elasticity index of the subjects has been greatly improved. It can be seen that the firming and repairing moisturizing cream of the present invention has the functions of significantly increasing skin elasticity and removing wrinkles.

实验例10Experimental Example 10

对实施例4~7和对比例1~8的修复保湿霜的使用功效:收缩毛孔、淡斑、去皱的效果进行评价,结果如表3所示:The use efficacy of the repairing moisturizing creams of Examples 4-7 and Comparative Examples 1-8: the effects of shrinking pores, lightening spots, and removing wrinkles were evaluated. The results are shown in Table 3:

评价方法:由120名,每个实施例10名专业评估人员进行使用测试。评估人员每人将各试样涂布于脸部,按下述等级绝对评价进行评分,合计评估人员全体的评分,算出其平均值,根据下述等级判定基准进行判定。需要说明的是,对评价项目将试样涂布于脸部,试用人员每天试用1次,连续试用一周,评估人员经过试用一周后进行评价。Evaluation method: The use test was conducted by 120 people, 10 professional evaluators for each example. Each of the evaluators applied each sample to the face, and scored according to the following grade absolute evaluation. The scores of all the evaluators were totaled, the average value was calculated, and the evaluation was made according to the following grade judgment criteria. It should be noted that, for the evaluation items, the sample was applied to the face, and the tester tried it once a day for one week, and the evaluator made an evaluation after the test for one week.

评价项目:收缩毛孔、淡斑、去皱。Evaluation items: shrink pores, fade spots, and remove wrinkles.

等级绝对评价评分:Rating Absolute Rating Score:

非常好:5分Very good: 5 points

良好:4分Good: 4 points

稍好:3分Slightly better: 3 points

普通:2分Normal: 2 points

稍差:1分Slightly worse: 1 point

差:0分Poor: 0 points

表3table 3

样品sample 收缩毛孔Shrink pores 淡斑light spots 去皱wrinkle 实施例4Example 4 55 4.94.9 55 实施例5Example 5 3.93.9 4.24.2 4.34.3 实施例6Example 6 4.14.1 4.34.3 4.44.4 实施例7Example 7 4.54.5 4.44.4 4.24.2 对比例1Comparative Example 1 1.71.7 1.81.8 1.81.8 对比例2Comparative Example 2 2.12.1 2.32.3 2.22.2 对比例3Comparative Example 3 2.52.5 2.62.6 2.72.7 对比例4Comparative Example 4 2.52.5 2.42.4 2.52.5 对比例5Comparative Example 5 2.42.4 2.82.8 2.32.3 对比例6Comparative Example 6 2.82.8 2.52.5 2.12.1 对比例7Comparative Example 7 2.62.6 2.32.3 2.42.4 对比例8Comparative Example 8 2.22.2 2.52.5 2.52.5

该评价过程中产品收缩毛孔、淡斑、去皱的效果检测方法为:使用美国Visia皮肤检测仪检测使用实施例4~7和对比例1~8的试样前后的毛孔、斑点、皱纹。毛孔反映皮脂腺开孔的扩张情况和平整度,因为张开的毛孔会有阴影,它的颜色会比正常肤色深;脸部反映的是脸部的干纹、细纹、静态纹等状况,被Visia皮肤检测仪扫描到的皱纹会被勾勒成一条条细线。In the evaluation process, the method for detecting the effect of the product on shrinking pores, lightening spots and removing wrinkles is as follows: using the American Visia skin tester to detect the pores, spots and wrinkles before and after the samples of Examples 4-7 and Comparative Examples 1-8 are used. Pores reflect the expansion and smoothness of sebaceous gland openings, because open pores will have shadows, and their color will be darker than normal skin color; the face reflects dry lines, fine lines, static lines, etc. Wrinkles scanned by the Visia skin detector are outlined as thin lines.

1.毛孔:使用试样前利用Visia皮肤检测仪读取皮肤深色点,检测3次取平均值;使用试样一周后再使用Visia检测,检测3次取平均值。1. Pores: Before using the sample, use the Visia skin detector to read the dark spots on the skin, and measure 3 times to take the average; use the sample for one week and then use Visia to detect, and measure 3 times to take the average.

2.斑点:使用试样前利用Visia皮肤检测仪读取皮肤斑点,检测3次取平均值;使用试样一周后再使用Visia检测,检测3次取平均值;检测斑点为利用标准白光拍摄,指的是肉眼可见、皮肤表面的斑点或表皮其它色素沉淀。2. Spots: Before using the sample, use Visia skin detector to read skin spots, and measure 3 times to get the average value; use Visia to detect the sample after one week, and measure 3 times to get the average value; the detected spots are photographed with standard white light, Refers to visible spots on the skin surface or other pigmentation of the epidermis.

3.皱纹:使用试样前利用Visia皮肤检测仪读取皮肤条条细线,检测3次取平均值;使用试样一周后再使用Visia检测,检测3次取平均值。3. Wrinkles: Before using the sample, use the Visia skin detector to read the thin lines of the skin, and measure 3 times to take the average; use the sample for one week and then use Visia to detect, and measure 3 times to take the average.

结果如表4所示,其中其中毛孔改善率=(使用前斑点数-使用后斑点数)/使用前斑点数;斑点改善率=(使用前斑点数-使用后斑点数)/使用前斑点数;皱纹改善率=(使用前细线数-使用后细线数)/使用前细线数。The results are shown in Table 4, where the pore improvement rate=(the number of spots before use-the number of spots after use)/the number of spots before use; the improvement rate of spots=(the number of spots before use-the number of spots after use)/the number of spots before use ; Wrinkle improvement rate=(the number of thin lines before use - the number of thin lines after use)/the number of thin lines before use.

表4Table 4

样品sample 毛孔改善率%Pore Improvement % 斑点改善率%Spot improvement % 皱纹改善率%Wrinkle improvement rate % 实施例4Example 4 38.838.8 29.129.1 26.526.5 实施例5Example 5 25.425.4 23.723.7 21.121.1 实施例6Example 6 32.132.1 21.221.2 21.121.1 实施例7Example 7 32.832.8 21.521.5 21.821.8 对比例1Comparative Example 1 15.515.5 11.711.7 12.712.7 对比例2Comparative Example 2 14.514.5 12.812.8 11.211.2 对比例3Comparative Example 3 15.415.4 12.312.3 11.811.8 对比例4Comparative Example 4 14.814.8 11.211.2 12.112.1 对比例5Comparative Example 5 15.115.1 12.412.4 11.611.6 对比例6Comparative Example 6 16.716.7 11.511.5 12.112.1 对比例7Comparative Example 7 14.314.3 11.811.8 11.811.8 对比例8Comparative Example 8 15.315.3 11.611.6 11.511.5

由表3和表4的结果可知本发明实施例4~7所制备的修复保湿霜中含海茴香(CRITHMUM MARITIMUM)提取物与积雪草(CENTELLA ASIATICA)提取物、仙桃仙人掌(OPUNTIA FICUS-INDICA)茎提取物、药用层孔菌(FOMES OFFICINALIS)提取物、石榴皮(PUNICA GRANATUM)提取物、库拉索芦荟叶汁、透明质酸钠混合物复合搭配的皮肤调理剂,相比于对比例1~8所制备的保湿霜产品,具有更好的改善皮肤毛孔、皮肤斑点和皮肤皱纹的效果和总体评价。From the results in Table 3 and Table 4, it can be seen that the repair moisturizing cream prepared in Examples 4 to 7 of the present invention contains sea fennel (CRITHMUM MARITIMUM) extract and Centella asiatica (CENTELLA ASIATICA) extract, Peach cactus (OPUNTIA FICUS-INDICA) ) stem extract, medicinal FOMES OFFICINALIS (FOMES OFFICINALIS) extract, pomegranate peel (PUNICA GRANATUM) extract, aloe vera leaf juice, sodium hyaluronate blended skin conditioning agent, compared to the comparative example The moisturizing cream products prepared in 1-8 have better effects and overall evaluation on improving skin pores, skin spots and skin wrinkles.

实施例11Example 11

对实施例4~7和对比例1~8的进行保湿度测试。测试方法为:由120名皮肤健康且皮肤含水量相近的志愿者,每10名志愿者为1组,每组使用同种配方的修复保湿霜。The moisturizing degree test was carried out for Examples 4-7 and Comparative Examples 1-8. The test method is as follows: 120 volunteers with healthy skin and similar skin moisture content, each 10 volunteers is a group, and each group uses a repairing moisturizing cream with the same formula.

每组志愿者使用同款洁面乳清洁后,眉心正中间往上2cm额头区域(A),下嘴唇正中间往下2cm下巴区域(A1)、鼻尖与瞳孔交线处左、右脸颊区域(A2),使用对应实施例与对比例的修复保湿霜,并在使用后1小时候后通过日本belulu公司的KRD1042型号皮肤水分测试仪测试水分含量。连续使用一周后进行测试,取各组测量数据平均值进行对比,测试结果如表5所示;测试使用四周后进行测试,取各组测量数据平均值进行对比,测试结果如表6所示。After each group of volunteers used the same facial cleanser to cleanse, the forehead area was 2 cm upward from the center of the eyebrows (A), the chin area was 2 cm downward from the middle of the lower lip (A1), and the left and right cheek areas at the intersection of the nose tip and the pupil (A2 ), use the repair moisturizing cream of the corresponding embodiment and the comparative example, and test the moisture content by the KRD1042 model skin moisture tester of Japan belulu company 1 hour after use. After continuous use for one week, the test was carried out, and the average value of each group of measurement data was compared, and the test results were shown in Table 5; the test was tested after four weeks of use, and the average value of each group of measurement data was compared, and the test results were shown in Table 6.

表5table 5

Figure BDA0002621261430000161
Figure BDA0002621261430000161

表6Table 6

Figure BDA0002621261430000171
Figure BDA0002621261430000171

从表5可见,实施例4~7制备的修复保湿霜产品中含海茴香(CRITHMUMMARITIMUM)提取物与积雪草(CENTELLA ASIATICA)提取物、仙桃仙人掌(OPUNTIA FICUS-INDICA)茎提取物、药用层孔菌(FOMES OFFICINALIS)提取物、石榴皮(PUNICA GRANATUM)提取物、透明质酸钠混合物、库拉索芦荟叶汁复合搭配的皮肤调理剂,相比于对比例1~7所制备的保湿霜产品具有更有效提高皮肤的保湿性能;从表6可见,实施例4~7制备的修复保湿霜产品在持续使用后,相比于对比例1~7所制备的保湿霜产品,皮肤的水含量提高明显,说明该产品可有效修复和提高皮肤锁水能力,起到帮助皮肤屏障功能恢复的作用。As can be seen from Table 5, the repair moisturizing cream products prepared in Examples 4 to 7 contain sea fennel (CRITHMUMMARITIMUM) extract and Centella asiatica (CENTELLA Asiatica) extract, Peach cactus (OPUNTIA FICUS-INDICA) stem extract, medicinal The skin conditioning agent of FOMES OFFICINALIS extract, pomegranate peel (PUNICA GRANATUM) extract, sodium hyaluronate mixture, and aloe vera leaf juice, compared with the moisturizing agents prepared in Comparative Examples 1-7 The cream product has a more effective moisturizing performance for improving the skin; it can be seen from Table 6 that after continuous use of the repairing moisturizing cream products prepared in Examples 4-7, compared with the moisturizing cream products prepared in Comparative Examples 1-7, the skin moisture The content increased significantly, indicating that the product can effectively repair and improve the skin's water-locking ability, and play a role in helping the skin barrier function recover.

实施例12Example 12

对实施例4~7和对比例1~8的进行经皮失水率测试。测试方法为:由120名皮肤健康且皮肤含水量相近的志愿者,每10名志愿者为1组,每组使用同种配方的修复保湿霜。The percutaneous water loss rate test was carried out for Examples 4 to 7 and Comparative Examples 1 to 8. The test method is as follows: 120 volunteers with healthy skin and similar skin moisture content, each 10 volunteers is a group, and each group uses a repairing moisturizing cream with the same formula.

每组志愿者使用同款洁面乳清洁后,眉心正中间往上2cm额头区域,下嘴唇正中间往下2cm下巴区域、鼻尖与瞳孔交线处左、右脸颊区域三处使用对应实施例与对比例的修复保湿霜,使用德国CK公司TM300型号的TEWL皮肤水分流失测试仪分别测试使用前和连续使用四周后各组测量数据,得到各组志愿者的经皮失水率平均值,测试结果如表7所示。Each group of volunteers used the same facial cleanser to clean the forehead area 2cm above the center of the eyebrows, 2cm below the chin area from the middle of the lower lip, left and right cheek areas where the nose tip and the pupil intersect. Proportion of the repairing moisturizing cream, use the TEWL skin moisture loss tester of the German CK company TM300 model to test the measurement data of each group before use and after continuous use for four weeks, and obtain the average value of the transdermal water loss rate of each group of volunteers. The test results are as follows shown in Table 7.

表7Table 7

项目project 使用前(g/hm<sup>2</sup>)Before use (g/hm<sup>2</sup>) 使用后(g/hm<sup>2</sup>)After use (g/hm<sup>2</sup>) 实施例4Example 4 11.8611.86 9.649.64 实施例5Example 5 11.8111.81 9.789.78 实施例6Example 6 11.7311.73 9.839.83 实施例7Example 7 11.8911.89 9.979.97 对比例1Comparative Example 1 11.8311.83 11.2311.23 对比例2Comparative Example 2 11.7411.74 10.6810.68 对比例3Comparative Example 3 11.9111.91 10.8710.87 对比例4Comparative Example 4 11.8611.86 10.6710.67 对比例5Comparative Example 5 11.8211.82 10.7510.75 对比例6Comparative Example 6 11.9311.93 10.9310.93 对比例7Comparative Example 7 11.8711.87 10.8310.83 对比例8Comparative Example 8 11.9011.90 10.9610.96

从表7可见,与实施例11的结果相似,实施例4~7制备的修复保湿霜产品能明显降低经皮失水率至10g/hm2以下,而对比例1~8所制备的保湿霜产品的水分提升效果则明显不足,说明本发明所制备的含有海茴香(CRITHMUM MARITIMUM)提取物与积雪草(CENTELLAASIATICA)提取物、仙桃仙人掌(OPUNTIA FICUS-INDICA)茎提取物、药用层孔菌(FOMESOFFICINALIS)提取物、石榴皮(PUNICA GRANATUM)提取物、透明质酸钠混合物、库拉索芦荟叶汁活性成分的修复保湿霜产品可有效提高皮肤的保湿性能和修复皮肤锁水功能。As can be seen from Table 7, similar to the results of Example 11, the repairing moisturizing cream products prepared in Examples 4-7 can significantly reduce the transdermal water loss rate to below 10 g /hm2, while the moisturizing creams prepared in Comparative Examples 1-8 The moisture lifting effect of the product is obviously insufficient, indicating that the prepared by the present invention contains sea fennel (CRITHMUM MARITIMUM) extract and Centella asiatica (CENTELLAASIATICA) extract, Peach cactus (OPUNTIA FICUS-INDICA) stem extract, medicinal layer pore Bacteria (FOMESOFFICINALIS) extract, pomegranate peel (PUNICA GRANATUM) extract, sodium hyaluronate mixture, aloe vera leaf juice active ingredients repair moisturizing cream products can effectively improve the skin's moisturizing properties and repair the skin's water-locking function.

最后所应当说明的是,以上实施例仅用以说明本发明的技术方案而非对本发明保护范围的限制,尽管参照较佳实施例对本发明作了详细说明,本领域的普通技术人员应当理解,可以对本发明的技术方案进行修改或者等同替换,而不脱离本发明技术方案的实质和范围。Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and not to limit the protection scope of the present invention. Although the present invention is described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that, The technical solutions of the present invention may be modified or equivalently replaced without departing from the spirit and scope of the technical solutions of the present invention.

Claims (10)

1.一种皮肤调理组合物,其特征在于,包括以下重量份的组分:石榴皮提取物0.1~2份、仙桃仙人掌茎提取物1~20份、库拉索芦荟叶汁1~20份、药用层孔菌提取物1~15份、积雪草提取物1~20份、烟酰胺1~8份、透明质酸钠混合物0.1~12份和海茴香提取物1~20份,所述透明质酸钠混合物包括透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠的至少一种;优选地,皮肤调理组合物包括以下重量份的组分:石榴皮提取物0.5份、仙桃仙人掌茎提取物8份、库拉索芦荟叶汁8份、药用层孔菌提取物5份、积雪草提取物8份、烟酰胺3份、透明质酸钠混合物5份和海茴香提取物10份。1. A skin conditioning composition, comprising the following components by weight: 0.1 to 2 parts of pomegranate peel extract, 1 to 20 parts of peach cactus stem extract, 1 to 20 parts of aloe vera leaf juice , 1 to 15 parts of medicinal laminarum extract, 1 to 20 parts of Centella asiatica extract, 1 to 8 parts of niacinamide, 0.1 to 12 parts of sodium hyaluronate mixture and 1 to 20 parts of sea fennel extract, so The sodium hyaluronate mixture comprises at least one of sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate and acetylated sodium hyaluronate; preferably, the skin conditioning composition comprises the following parts by weight: Ingredients: 0.5 parts of pomegranate peel extract, 8 parts of peach cactus stem extract, 8 parts of aloe vera leaf juice, 5 parts of medicinal Phytoporus extract, 8 parts of Centella asiatica extract, 3 parts of niacinamide, Sodium Hyaluronate Blend 5 parts and Sea Fennel Extract 10 parts. 2.一种包含权利要求1所述皮肤调理组合物的化妆品,其特征在于,所述化妆品包括面膜液、精华液、护肤凝露、面霜和乳液中的至少一种。2 . A cosmetic product comprising the skin conditioning composition of claim 1 , wherein the cosmetic product comprises at least one of facial mask liquid, essence, skin care gel, face cream and lotion. 3 . 3.一种修复保湿霜,其特征在于,包括以下重量百分比的组分:0.01~70%保湿剂、0.1~5%吸附剂、0.1~8%增稠剂、0.1~23%润肤剂、0.01~0.8%螯合剂、0.1~5%抗氧化剂、0.1~6%乳化剂、0.1~2%pH调节剂、0.1~90%皮肤调理剂和余量水;所述皮肤调理剂包括占所述修复保湿霜的原料组分重量百分比0.1~0.8%的尿囊素、0.1~3%的羟苯基丙酰胺苯甲酸、0.1~2%的石榴皮提取物、1~20%的仙桃仙人掌茎提取物、1~20%的库拉索芦荟叶汁、1~15%的药用层孔菌提取物、1~20%的积雪草提取物、1~8%的烟酰胺、0.1~12%的透明质酸钠混合物和1~20%的海茴香提取物;所述透明质酸钠混合物包括透明质酸钠交联聚合物、透明质酸钠、水解透明质酸钠和乙酰化透明质酸钠的至少一种。3. A repair moisturizing cream, characterized in that it comprises the following components by weight: 0.01-70% moisturizing agent, 0.1-5% adsorbent, 0.1-8% thickening agent, 0.1-23% emollient, 0.01-0.8% chelating agent, 0.1-5% antioxidant, 0.1-6% emulsifier, 0.1-2% pH adjuster, 0.1-90% skin conditioning agent and balance water; The raw material components of the repair moisturizing cream are 0.1-0.8% allantoin, 0.1-3% hydroxyphenyl propanamide benzoic acid, 0.1-2% pomegranate peel extract, 1-20% peach cactus stem extraction extract, 1-20% Aloe vera leaf juice, 1-15% Phytophthora medicinal extract, 1-20% Centella asiatica extract, 1-8% niacinamide, 0.1-12% The sodium hyaluronate mixture and 1-20% sea fennel extract; the sodium hyaluronate mixture includes sodium hyaluronate cross-linked polymer, sodium hyaluronate, hydrolyzed sodium hyaluronate and acetylated hyaluronic acid at least one of sodium. 4.如权利要求3所述修复保湿霜,其特征在于,所述润肤剂包括占所述修复保湿霜的原料组分重量百分比0.1~8%的环五聚二甲基硅氧烷、0.1~6%的异壬酸异壬酯、0.1~3%的聚二甲基硅氧烷、0.1~3%的硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、0.1~3%的霍霍巴籽油和0.1~0.8%的辛酰羟肟酸;所述保湿剂包括占所述修复保湿霜的原料组分重量百分比1~15%的甘油、1~20%的丁二醇、0.01~8%的甘油聚醚-26、1~5%的赤藓醇、0.1~6%的糖类同分异构体、0.1~3%的1,2-戊二醇、0.1~3%的1,2-己二醇和0.01~0.5%的乙基己基甘油。The repairing moisturizing cream according to claim 3, wherein the emollient comprises 0.1-8% by weight of the raw material components of the repairing moisturizing cream, cyclopentasiloxane, 0.1 ~6% isononyl isononanoate, 0.1~3% dimethicone, 0.1~3% stearyl methicone/dimethicone copolymer, 0.1~3% % of jojoba seed oil and 0.1-0.8% of caprylyl hydroxamic acid; the moisturizing agent comprises 1-15% of glycerin and 1-20% of butanediol in the weight percentage of the raw material components of the repair moisturizing cream , 0.01-8% glycerol polyether-26, 1-5% erythritol, 0.1-6% saccharide isomer, 0.1-3% 1,2-pentanediol, 0.1-3% % of 1,2-hexanediol and 0.01 to 0.5% of ethylhexylglycerol. 5.如权利要求3所述修复保湿霜,其特征在于,所述增稠剂包括占所述修复保湿霜的原料组分重量百分比0.1~3%的丙烯酰二甲基牛磺酸铵/VP共聚物和0.1~3%的丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物。The repairing moisturizing cream according to claim 3, wherein the thickening agent comprises 0.1-3% by weight of the raw material components of the repairing moisturizing cream, ammonium acryloyldimethyltaurate/VP Copolymer and 0.1 to 3% of hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer. 6.如权利要求3所述修复保湿霜,其特征在于,所述螯合剂包括占所述修复保湿霜的原料组分重量百分比0.01~0.1%的EDTA-二钠和0.1~0.8%的甘油辛酸酯。6 . The repairing moisturizing cream according to claim 3 , wherein the chelating agent comprises 0.01-0.1% of EDTA-disodium and 0.1-0.8% of glycerin caprylic acid by weight of the raw material components of the repairing moisturizing cream. 7 . acid ester. 7.如权利要求3所述修复保湿霜,其特征在于,所述抗氧化剂包括占所述修复保湿霜的原料组分重量百分比0.1~3%的生育酚乙酸酯和0.1~2%的对羟基苯乙酮。7 . The repairing moisturizing cream according to claim 3 , wherein the antioxidant comprises 0.1-3% of tocopheryl acetate and 0.1-2% of paraben by weight of the raw material components of the repairing moisturizing cream. 8 . Hydroxyacetophenone. 8.如权利要求3所述修复保湿霜,其特征在于,所述乳化剂包括占所述修复保湿霜的原料组分重量百分比0.1~3%的鲸蜡硬脂醇橄榄油酸酯和0.1~3%的山梨坦橄榄油酸酯;所述吸附剂为占所述修复保湿霜的原料组分重量百分比0.1~5%的硅石;所述pH调节剂为占所述修复保湿霜的原料组分重量百分比0.1~2%的精氨酸。8 . The repairing moisturizing cream according to claim 3 , wherein the emulsifier comprises 0.1-3% by weight of the raw material components of the repairing moisturizing cream and 0.1-3% of cetearyl oleic acid ester and 0.1- 3% of sorbitan oleic acid ester; the adsorbent is 0.1-5% by weight of the raw material component of the repair moisturizing cream; the pH adjuster is the raw material component of the repair moisturizing cream 0.1-2% arginine by weight. 9.如权利要求3所述修复保湿霜,其特征在于,所述修复保湿霜包括以下重量百分比的组分:5%甘油、8%丁二醇、3%甘油聚醚-26、3%赤藓醇、2%糖类同分异构体、1%1,2-戊二醇、1%1,2-己二醇、0.1%乙基己基甘油、2%硅石、1%丙烯酰二甲基牛磺酸铵/VP共聚物、1%丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物、0.05%EDTA-二钠、0.3%甘油辛酸酯、1%生育酚乙酸酯、0.5%对羟基苯乙酮、1%鲸蜡硬脂醇橄榄油酸酯、1%山梨坦橄榄油酸酯、0.5%精氨酸、3%环五聚二甲基硅氧烷、2%异壬酸异壬酯、1%聚二甲基硅氧烷、1%硬脂氧聚甲硅氧烷/聚二甲硅氧烷共聚物、1%霍霍巴籽油、0.3%辛酰羟肟酸、0.3%尿囊素、1%羟苯基丙酰胺苯甲酸、0.5%石榴皮提取物、8%仙桃仙人掌茎提取物、8%库拉索芦荟叶汁、5%药用层孔菌提取物、8%积雪草提取物、3%烟酰胺、5%透明质酸钠混合物、10%海茴香提取物和余量水。9. The repairing moisturizing cream of claim 3, wherein the repairing moisturizing cream comprises the following components by weight: 5% glycerol, 8% butylene glycol, 3% glycerol polyether-26, 3% red Thiol, 2% Saccharide Isomers, 1% 1,2-Pentanediol, 1% 1,2-Hexanediol, 0.1% Ethylhexylglycerol, 2% Silica, 1% Acryloyl Dimethyl Ammonium Taurine/VP Copolymer, 1% Hydroxyethyl Acrylate/Sodium Acryloyldimethyltaurate Copolymer, 0.05% EDTA-Disodium, 0.3% Glycerol Caprylate, 1% Tocopheryl Acetate , 0.5% p-hydroxyacetophenone, 1% cetearyl oleate, 1% sorbitan oleate, 0.5% arginine, 3% cyclopentamethicone, 2% Isononyl isononanoate, 1% Dimethicone, 1% Stearyloxymethicone/Dimethicone Copolymer, 1% Jojoba Seed Oil, 0.3% Capryloyl Hydroxime Acid, 0.3% Allantoin, 1% Hydroxyphenyl Propionamide Benzoic Acid, 0.5% Pomegranate Peel Extract, 8% Prickly Pear Cactus Stem Extract, 8% Aloe Vera Leaf Juice, 5% Phytophthora Medicinalis Extract extract, 8% Centella asiatica extract, 3% niacinamide, 5% sodium hyaluronate blend, 10% sea fennel extract and balance water. 10.如权利要求3~8任一项所述修复保湿霜的制备方法,其特征在于,所述制备方法为:将保湿剂和吸附剂加入水中,在80~100℃混合搅拌20~30min后,依次加入增稠剂、润肤剂、螯合剂、抗氧化剂和乳化剂后继续搅拌5~8min,并降温至40~50℃,加入pH调节剂和皮肤调理剂后搅拌混合均匀,即得所述修复保湿霜。10. The preparation method of the repair moisturizing cream according to any one of claims 3 to 8, wherein the preparation method is as follows: adding a moisturizing agent and an adsorbent to water, and mixing and stirring at 80 to 100° C. for 20 to 30 minutes after , add thickener, emollient, chelating agent, antioxidant and emulsifier in turn, continue to stir for 5-8 min, and cool down to 40-50 ℃, add pH adjuster and skin conditioning agent, stir and mix evenly, that is, Described Restorative Moisturizer.
CN202010785976.XA 2020-08-06 2020-08-06 A kind of repair moisturizing cream and preparation method thereof Pending CN111920730A (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112826754A (en) * 2021-01-26 2021-05-25 广东丸美生物技术股份有限公司 Concentrated lotion matrix and preparation method and application thereof
CN113499299A (en) * 2021-07-01 2021-10-15 上海先妍生物技术有限公司 Face cream and preparation method thereof
CN114042027A (en) * 2021-11-15 2022-02-15 广州环亚化妆品科技股份有限公司 Composition with sensitive muscle repairing effect and preparation method and application thereof
CN116459191A (en) * 2023-05-08 2023-07-21 深圳市理然化妆品有限公司 A kind of oil control moisturizing composition and its preparation method and application

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102670445A (en) * 2012-05-23 2012-09-19 成都鹏翔生物科技有限公司 Chinese medicinal face repair cream and preparation method thereof
CN104825373A (en) * 2015-06-03 2015-08-12 刘沛溢 Application of moderate botanical extract composition in cosmetics and preparation method thereof
CN107334725A (en) * 2017-08-08 2017-11-10 广州蜜妆生物科技有限公司 A kind of anti-ageing American's flesh facial mask of Crithmum maritimum
CN110384652A (en) * 2018-04-12 2019-10-29 杨智浩 A kind of skin nursing reduces sensitive, composition of hormone dependant and preparation method thereof
CN111084743A (en) * 2020-01-19 2020-05-01 广州果壳化妆品有限公司 Pore astringing essence and preparation method thereof
CN111329808A (en) * 2020-04-03 2020-06-26 西安力邦医美科技有限公司 Cosmetic composition with anti-glycosylation and anti-aging effects and application thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102670445A (en) * 2012-05-23 2012-09-19 成都鹏翔生物科技有限公司 Chinese medicinal face repair cream and preparation method thereof
CN104825373A (en) * 2015-06-03 2015-08-12 刘沛溢 Application of moderate botanical extract composition in cosmetics and preparation method thereof
CN107334725A (en) * 2017-08-08 2017-11-10 广州蜜妆生物科技有限公司 A kind of anti-ageing American's flesh facial mask of Crithmum maritimum
CN110384652A (en) * 2018-04-12 2019-10-29 杨智浩 A kind of skin nursing reduces sensitive, composition of hormone dependant and preparation method thereof
CN111084743A (en) * 2020-01-19 2020-05-01 广州果壳化妆品有限公司 Pore astringing essence and preparation method thereof
CN111329808A (en) * 2020-04-03 2020-06-26 西安力邦医美科技有限公司 Cosmetic composition with anti-glycosylation and anti-aging effects and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
广州果壳化妆品有限公司: "果壳酵母细致保湿乳", 《国产非特殊用途化妆品备案信息服务平台》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112826754A (en) * 2021-01-26 2021-05-25 广东丸美生物技术股份有限公司 Concentrated lotion matrix and preparation method and application thereof
CN113499299A (en) * 2021-07-01 2021-10-15 上海先妍生物技术有限公司 Face cream and preparation method thereof
CN114042027A (en) * 2021-11-15 2022-02-15 广州环亚化妆品科技股份有限公司 Composition with sensitive muscle repairing effect and preparation method and application thereof
CN116459191A (en) * 2023-05-08 2023-07-21 深圳市理然化妆品有限公司 A kind of oil control moisturizing composition and its preparation method and application

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