CN111904660B - Valve clamping device and valve clamping system - Google Patents

Abstract

The application relates to a valve clamping system, which comprises a valve clamping device and a conveying device, wherein the valve clamping device comprises a supporting part, and the supporting part comprises a connecting end and a free end which are oppositely arranged; at least one part of the supporting part is arranged in the adjusting part, one end of the adjusting part is sleeved outside the connecting end and is connected with the supporting part, and the other end of the adjusting part is provided with an opening; the clamping part is arranged around the outer side of the adjusting part; the driving part is connected with the clamping part to drive the clamping part to unfold or close around the adjusting part. The regulating part is provided with an open free end which is not limited by the sealing head, the axial deformation capacity of the regulating part is improved, the bending deformation capacity along the axial direction is enhanced, the regulating part is easily compressed into the sheath, the regulating part can adapt to blood vessels with different bending degrees during conveying, and the damage to the blood vessel wall is reduced. After the valve is implanted, the axial deformation of the adjusting part is not limited, so that the elastic fitting property of the valve leaflet and the adjusting part is improved, and the adaptability of the physiological structures of the valve leaflets of different patients is improved.

Description

Valve clipping device and valve clipping system

technical field

The present application relates to the field of implanted medical devices, in particular to a valve clamping device and a valve clamping system including the valve clamping device.

Background technique

Referring to Figure 1, the mitral valve 1 is a one-way valve located between the left atrium 2 and the left ventricle 3 of the heart. A normal and healthy mitral valve 1 can control the flow of blood from the left atrium 2 to the left ventricle 3 while preventing blood from flowing from the left atrium 2 to the left ventricle 3. The ventricle 3 flows to the left atrium 2 . The mitral valve 1 includes a pair of leaflets called an anterior leaflet 1a and a posterior leaflet 1b. The anterior lobe 1a and the posterior lobe 1b are fixed to the papillary muscle of the left ventricle 3 through the chordae 4 . Under normal circumstances, when the left ventricle 3 of the heart contracts, the edges of the anterior lobe 1a and the posterior lobe 1b are completely joined to prevent blood from flowing from the left ventricle 3 to the left atrium 2 . Referring to Figure 2, when the leaflets of mitral valve 1 or its related structures undergo organic or functional changes, such as partial rupture of the chordae 4, poor alignment of the anterior leaflet 1a and posterior leaflet 1b of the mitral valve 1, Therefore, when the left ventricle 3 of the heart contracts, the mitral valve 1 cannot be completely closed, causing blood to flow back from the left ventricle 3 to the left atrium 2, thereby causing a series of pathophysiological changes called "mitral valve regurgitation" .

The prior art treats mitral valve regurgitation by implanting a valve clipping device into the mitral valve, with a pair of closable forceps arms pulling the anterior and posterior leaflets toward each other, reducing or eliminating the leaflet gap. Referring to Fig. 3 and Fig. 4, an existing valve clamping device adds an elastic body 20 to the two forceps arms 30, and the leaflets on each side are clamped on one side of the forceps arm 30 and the elastic body 20 respectively. Between the two sides, the distance between the leaflets is adapted by the deformation of the elastic body 20, thereby adjusting the pulling degree of the leaflets by the forceps arm 30. The elastic body 20 includes a deformable net-like main body 21, both ends of which are fixed by heads 24 such as steel sleeves, and then fixed on the support rod between the two pliers arms 30. However, since both ends of the elastic body 20 are fixed by the head 24, when the clamp arm 30 is closed, the head 24 restricts the axial movement of the elastic body, and the elastic body can only be compressed radially, which affects the elastic body. Deformation, thereby increasing the size of the clipping device in the delivery state, is not conducive to the passage of the clipping device in the curved blood vessel, and will cause the elastic body to not fully fit the valve leaflet after the clipper is implanted, which is different for different patients. The adaptability of the valve leaflet physiological structure is poor.

Contents of the invention

In order to solve the above technical problems or at least partly solve the above technical problems, the present application provides a valve clamping device and a valve clamping system including the valve clamping device.

In a first aspect, the present application provides a valve clamping device, comprising:

a supporting part, the supporting part includes a connecting end and a free end arranged oppositely;

A hollow adjustment part, at least a part of the support part is arranged in the adjustment part, one end of the adjustment part is sleeved outside the connection end and connected with the support part, the free end of the support part is located in the adjustment part, and the free end is used for Due to the detachable connection with the conveying device, the other end of the adjustment part is free to hang;

A clamping part, the clamping part is surrounded by the outer side of the adjustment part;

The driving part is connected with the clamping part to drive the clamping part to expand or close around the adjusting part.

In a second aspect, the present application provides a valve clamping system, including any one of the valve clamping devices described above, and a delivery device, wherein the delivery device includes: a push shaft with a certain axial length and a movably mounted on The mandrel in the push shaft is detachably connected between the push shaft and the supporting part, and the mandrel is connected with the driving part for driving the expansion and closing of the clamping part relative to the supporting part.

Compared with the prior art, the above-mentioned technical solution provided by the embodiment of the present application has at least the following advantages: for the valve clamping device and the valve clamping system including the valve clamping device, at least a part of the support part is arranged in the hollow of the adjustment part , one end of the adjustment part is sleeved outside the connection end and connected with the support part, the other end of the adjustment part is free to hang in the air. The limitation of the adjustment part improves the axial deformation ability of the adjustment part, and at the same time enhances its bending deformation ability in the axial direction. Therefore, when the valve clamping device is radially compressed into the delivery device for in vivo delivery, it is not only easy to be compressed into the The sheath, and when delivered in blood vessels, can adapt to blood vessels with different curvatures, thereby facilitating the passage of the delivery device in blood vessels, thereby reducing damage to the blood vessel walls. In addition, after the valve clamping device is implanted, during the process of clamping the valve leaflet and the adjustment part with the forceps arms, since the axial deformation of the adjustment part is not limited, the elastic fit between the valve leaflet and the adjustment part can be improved, and then the The adaptability of valve leaflet physiological structure in different patients.

Description of drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments consistent with the invention and together with the description serve to explain the principles of the invention.

In order to more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the following will briefly introduce the drawings that need to be used in the description of the embodiments or the prior art. Obviously, for those of ordinary skill in the art, In other words, other drawings can also be obtained from these drawings without paying creative labor.

Fig. 1 is the schematic diagram when the mitral valve is in a normal state;

Figure 2 is a schematic diagram of mitral valve disease;

Fig. 3 and Fig. 4 are the structural schematic diagrams of the valve clamping device in the prior art;

Fig. 5 is a schematic structural view of a valve clamping device according to the first embodiment of the present application;

Fig. 6 is a schematic structural diagram of the combination of the adjustment part and the support part in Fig. 5;

Fig. 7 is a schematic structural view of the supporting part in Fig. 5;

Fig. 8 is a schematic structural view of the regulating part in Fig. 5;

Fig. 9A is a structural schematic diagram of preparing the tube body of the regulating part in Fig. 5 in an example;

Fig. 9B is a schematic structural view of the frame structure after the pipe body in Fig. 9A has been cut and shaped;

Figure 9C is a schematic diagram of the structure of an exemplary elastic body prepared by cutting;

Figure 9D is a schematic structural view of another exemplary elastic body prepared by cutting;

Figure 9E is a partial schematic view of the proximal portion of the elastic body in Figure 9D;

Fig. 9F is a schematic structural view of yet another example elastic body prepared by cutting;

Fig. 10A is a schematic diagram of an example mesh structure of the regulating part in Fig. 5;

Fig. 10B is a schematic diagram of another exemplary mesh structure of the regulating part in Fig. 5;

Fig. 11 is a partial schematic diagram of an example of an adjusting part having a ring structure in Fig. 5;

Fig. 12 is a schematic structural view of the combination of the clamping part and the driving part in Fig. 5;

Fig. 13 is a schematic diagram of the structure of the cooperation between the support part and the base in Fig. 5;

Fig. 14 is a schematic structural diagram of the cooperation between the valve clamping device and the delivery device in Fig. 5;

Fig. 15 is a structural schematic diagram of the cooperation between the support part of the valve clamping device in Fig. 5 and the delivery device;

Fig. 16-Fig. 20 are schematic diagrams of the delivery process of using the valve clipping device in Fig. 5 to antegradely approach and repair the mitral valve through the left atrium;

Fig. 21 is a schematic structural view of a valve clamping device according to the second embodiment of the present application;

Fig. 22 is a schematic structural view of the regulating part in Fig. 21;

Fig. 23 is a partial schematic diagram of the distal end of the adjustment part in Fig. 22;

Fig. 24A is a schematic structural view of a valve clamping device according to the third embodiment of the present application;

Fig. 24B is a schematic structural view of a preferred valve clamping device in Fig. 24A;

Fig. 25A is a schematic structural view of the first curved surface side of the adjustment part of a valve clamping device according to the fourth embodiment of the present application;

Fig. 25B is a schematic structural view of the second curved surface side of the adjustment part in Fig. 25A;

Fig. 25C is a top view of the adjustment part in Fig. 25A;

Fig. 26A is a schematic structural view of a valve clamping device according to the fifth embodiment of the present application;

Fig. 26B is a schematic structural view of the valve clipping device in Fig. 26A after being radially compressed and partially received in the delivery device.

Detailed ways

The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the orientation or positional relationship indicated by the terms "upper", "lower", "inner", "outer" and the like are based on the orientation or positional relationship shown in the accompanying drawings, and are only for It is convenient to describe the present invention and simplify the description, but does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and thus should not be construed as limiting the present invention. In addition, the terms "first", "second", etc. are used for descriptive purposes only, and should not be construed as indicating or implying relative importance.

In the description of the present invention, it should be noted that in the field of interventional medical devices, the proximal end refers to the end closer to the operator, while the distal end refers to the end farther from the operator; the axial direction refers to the end parallel to the medical device. The direction of the line connecting the center of the distal end and the center of the proximal end of the instrument. The above definitions are only for the convenience of expression, and should not be construed as limiting the present invention.

5-20, a valve clamping device 100 according to the first embodiment of the present invention includes: a support part 110, the support part 110 includes a connecting end 111 and a free end 112 arranged oppositely; a hollow adjustment part 120, supporting At least a part of the part 110 is arranged in the adjusting part 120, and one end 121a of the adjusting part 120 is sleeved on the outside of the connecting end 111 and connected with the supporting part 110, and the other end 121b of the adjusting part 120 is free to hang; the clamping part 130, the clamping part 130 surrounds the outer side of the adjusting part 120 ; the driving part 140 , the driving part 140 is connected with the clamping part 130 to drive the clamping part 130 to expand or close around the adjusting part 120 .

For the above-mentioned valve clamping device 100, at least a part of the support part 110 is arranged in the hollow of the adjustment part 120, and one end 121a of the adjustment part 120 is sleeved on the outside of the connection end 111 and connected with the support part 110, and the other end 121b of the adjustment part 120 Freely suspended, the freely suspended end is no longer restricted by the support part 110 or the delivery device 200, which improves the axial deformation capacity of the adjustment part 120, and at the same time enhances its axial bending deformation capacity, so when the valve is clamped When the device 100 is radially compressed into the delivery device for in vivo delivery, it is not only easy to be compressed into the sheath, but also can adapt to blood vessels with different curvatures during delivery in the blood vessel, thereby facilitating the passage of the delivery device in the blood vessel, thereby reducing damage to the vessel wall. In addition, after the valve clamping device 100 is implanted, during the process of clamping the valve leaflet and the adjustment part 120 by the forceps arm 131, since the axial deformation of the adjustment part 120 is not limited, the elastic fit between the valve leaflet and the adjustment part 120 can be improved. Compatibility, which in turn improves the adaptability of the valve leaflet physiological structure in different patients.

Referring to FIG. 6 and FIG. 7 , the supporting part 110 may be a circular tube whose two ends axially pass through. The distal end of the circular tube is a connecting end 111 , and the proximal end is a free end 112 . At least a part of the support part 110 is located in the hollow of the adjustment part 120, for example, the free end 112 of the support part 110 is located in the adjustment part 120, and the free end 112 is located in the adjustment part 120 in the delivery state and the unfolded state. The adjustment part 120 will be exposed. The supporting part 110 is also provided with an axial through-hole-shaped passageway 113 for interlocking cooperation with the driving part 140 and the conveying device 200 . The tube wall of the round tube body of the support part 110 is provided with at least two locking positions 114 for detachable connection with the delivery device 200 . For example, after the card table 221 (see FIG. 14 ) on the delivery device 200 is locked into the card position 114, the delivery device 200 is engaged with the support part 110 to carry out the delivery of the valve clamping device 100. When the card table 221 is out of the card position After 114, the delivery device 200 is separated from the valve clamping device 100 and released in vivo. It should be known that the structure of the supporting part 110 here is only used as an example, and is not a limitation to the present application. Those of ordinary skill in the art based on the teaching of the present application, adopt other structures of the supporting part 110, which are all within the protection scope of the present application. Inside.

In the valve clipping device 100 of the present application, the free end 112 of the proximal end is located in the hollow adjustment part 120 no matter in the delivery state or the released and expanded state, so it will never be exposed to the delivery device 200 or to the heart. In order to avoid the washing of blood and minimize the formation of thrombus after implantation. Moreover, after implantation, direct contact with the leaflets is avoided, and along with the long-term pulsation of the leaflets, wear and even perforation of the leaflets are avoided, which improves the safety of implanted patients.

Referring to FIG. 6 and FIG. 8 , the adjusting part 120 includes a deformable elastic body 123 having a hollow cavity, and at least a part of the supporting part 110 is disposed in the hollow cavity. One end 121 a of the elastic body 123 is connected to the supporting part 110 , and the other end 121 b of the elastic body 123 has an opening 122 and is freely suspended. The elastic main body 123 is deformable so as to adapt to the distance between different valve leaflets and adjust the pulling degree of the valve leaflets by the valve clamping device 100 . The opening 122 of the elastic body 123 is used to wear the distal end of the delivery device 200. It should be understood that the distal end of the delivery device 200 penetrates the inner cavity of the elastic body 123 through the opening 122 and connects with the proximal end (free end) of the support part 110. ), and the opening 122 of the distal end of the elastic body 123 is not connected to the distal end of the delivery device 200 or the proximal end (free end) of the support portion 110, that is, the proximal end 121b of the elastic body 123 is in a free-suspending state. Thus, during the delivery process or the process of clamping the leaflets, when the clamping part 130 is closed, the elastic body 123 in the adjustment part 120 is not restricted by the support part 110 or the delivery device 200, and can be balanced in both the radial direction and the axial direction. Deformable, with a large degree of deformation, more conducive to delivery, and stronger adaptability to valve leaflets; when the connection between the distal end of the delivery device 200 or the proximal end (free end) of the support part 110 is released, the adjustment part 120 The free-hanging end has a stronger deformation ability and a stronger adaptability to the leaflet.

In one of the embodiments, the elastic body 123 is a mesh structure, and the mesh structure can be woven from a shape memory material, for example, a superelastic nickel-titanium alloy material can be woven and heat-set to form a compressed state and the deployed state, which remain in the compressed state in the delivery device 200 and remain in the deployed state after release in vivo. In one of the embodiments, the elastic main body 123 of the network structure is braided. During manufacture, 12-36 nickel-titanium wires with a diameter of 0.02-0.15mm are wound on the liner rods, and the weaving forms a cylindrical shape. A woven mesh having oppositely disposed proximal and distal ends. At the proximal end, a plurality of mesh wires 124 are bent back to form a plurality of rings, and the plurality of rings are surrounded to form a proximal edge, and then a metal wire is passed through all the rings of the proximal end in order to tighten the wire appropriately, but Keep a decent size opening. Then the shaping mold is inserted from the far end of the braided mesh, and the nickel-titanium wire at the far end is wound into a bundle with a wire; the braided mesh and the shaping mold are put into an electric heating type circulating air box furnace at 450-650°C ( Preferably heat setting treatment at 500°C) for 10-20 minutes; take it out and cool to room temperature, remove the metal wires at the proximal and distal ends, take out the shaping mold, and insert all the nickel-titanium wires at the far end into stainless steel In the head, crimping or welding is performed to obtain the elastic main body 123 with a network structure.

Referring to FIGS. 9A and 9B , the elastic body 123 can also be a frame structure, and the frame structure is cut from relatively hard metal or polymer materials such as stainless steel, alloy, and polyvinyl chloride. The inner surface of the elastic main body 123 after cutting is smooth and flat, avoiding thrombus formation inside the elastic main body 123 and ensuring that the fixing member 220 (refer to FIG. 14 ) can be smoothly withdrawn from the opening 122 of the elastic main body 123 . The cutting method can be wire cutting or laser cutting, preferably laser cutting. During production, the nickel-titanium tube 126 is first cut into the desired shape by using a laser cutting machine. The nickel-titanium parts obtained by cutting are pressed into a shaping mold with a certain shape. Then put the nickel-titanium parts and the shaping mold into an electric heating circulating air box furnace at 450-650°C (preferably 500°C) for heat treatment for shaping for 10-20 minutes; take it out and cool to room temperature, remove the shaping mold to obtain the shaping The rear elastic body 123 is a frame structure and includes a plurality of struts 127 arranged at intervals in the radial direction and extending axially. The proximal ends of the plurality of struts 127 are gathered to form a freely suspended proximal edge. Distal ends of the plurality of struts 127 converge and are welded to the support portion 110 . The nickel-titanium tube is a pipe with a certain wall thickness. Specifically, the wall thickness of the nickel-titanium tube is less than 1 mm, preferably 0.02-0.15 mm, and has certain flexibility and rigidity.

Referring to Fig. 9C, the elastic body 123 is a frame structure formed by cutting, which is formed by a plurality of struts 127 being connected together. The proximal end 121b of the elastic body 123 is an open structure. The opening 122 is enclosed by the proximal edge.

Referring to Figures 9D and 9E, the elastic main body 123 is still a frame structure, formed by a plurality of struts 127 connected together, the proximal end 121b of the elastic main body 123 is an open structure, and each strut 127 at the proximal end 121b can also be provided with There are through holes 127a, and flexible wires 129 are passed between the through holes 127a to connect the through holes 127a in series to form the opening 122 .

Referring to FIG. 9F, the elastic body 123 is still a frame structure formed by a plurality of struts 127 that are connected together. The proximal end 121b of the elastic body 123 is an open structure. Adjacent struts 127 of the frame structure can be cut and intersected with each other. For example, adjacent struts 127 at the edge of the proximal end 121b are cross-linked to form a ring structure 129 after cutting.

Of course, the elastic body 123 of the adjustment part 120 can also be other elastic hollow structures, for example, the elastic body 123 can be a dense structure or a porous structure, the dense structure is silica colloid, the porous structure is sponge body, the dense structure or the porous structure The proximal edge forms an opening 122 for the distal end of the delivery device 200 to pass through the lumen of the elastic body 123 .

The shape of the elastic body 123 is selected from at least one of cylindrical, conical, spherical, oblate spheroidal, ellipsoidal, fan-shaped or gourd-shaped, and can also be a combination of multiple shapes. In order to prevent the elastic main body 123 from affecting the relative opening and closing between the clamping arm 151 and the forceps arm 131 and the support part 110, and avoid affecting the clamping effect on the leaflet, the diameter of the part of the elastic main body 123 near the distal end should be smaller than that of the elastic main body 123 diameter of other parts. For example, in the embodiment shown in FIG. 8 , the middle part of the elastic body 123 is columnar, and the two ends are cones, and the cone angles of the two cones are the same. It can be understood that, in other embodiments, the elastic body 123 can also be in any other shape, as long as the diameter of the distal end does not affect the clamping effect. For example, a spindle-shaped structure with the same taper angle at both ends as shown in FIG. 10A , or a structure with different taper angles at both ends as shown in FIG. 10B .

The adjustment part 120 includes a proximal end and a distal end. In one embodiment, a hollow snare structure (not shown) is sheathed on the proximal edge of the elastic body 123 to form an opening. The snare structure can be an existing Head structure. The snare structure can be annular or polygonal, and can be made of hard materials such as stainless steel, so that the wires of the mesh structure or the struts of the frame structure are properly gathered towards the central axis, but they are not closed, so that at the center of the snare structure An opening 122 is formed. In another embodiment, the proximal edge of the elastic body 123 surrounds the above-mentioned opening 122, and the size of the opening 122 is smaller than or equal to the size of the free end 112, so as to ensure that the free end 112 of the support part 110 is in both the compressed state and the expanded state. The adjustment part 120 will not protrude.

There are many ways to enclose the proximal edge of the elastic body 123 to form the above-mentioned opening 122. In a specific implementation manner of this embodiment, the mesh structure 123 is formed by braiding and heat setting of nickel-titanium alloy wires, and the mesh The mesh wire 124 of the shape structure 123 is bent back at the proximal end to form a proximal edge, that is, all the mesh wires 124 are surrounded by the folded part of the proximal edge to form an opening 122, and the shape of the winding can be set as required, for example, a winding Folding, or winding multiple times to form at least one loop and then winding back, etc., will not be repeated here.

The proximal edge of the elastic body 123 surrounds the opening 122, and the proximal head of the adjustment part 120 of the valve clamping device 100 is canceled. Deformation, the degree of deformation is relatively large, which is more conducive to delivery; in addition, the elastic body 123 is not restricted by the head to the axial movement of each mesh or strut, so it can be moderately curled or bent, so as to completely fit the leaflet, It can better adapt to the physiological structure of valve leaflets of different patients; in addition, it can also avoid the risk of falling off of the proximal head part in the prior art after being implanted for a period of time; in addition, the distal end of the elastic body 123 and the supporting part 110 connected, and the opening 122 at the proximal end is open, so the center of gravity is always located in the axial direction of the support part 110 (that is, the axis of the elastic body 123), so the self-centering is better and it is not easy to tilt.

Further, referring to FIG. 11 , the regulating part 120 may also include a ring structure 125 arranged at the edge of the proximal end to stabilize the shape of the opening 122 . connect. The annular structure 125 is made of flexible or elastic material, and its wire diameter is larger than the wire diameter of the mesh wire of the woven mesh structure 123, thereby providing a certain supporting force for the opening 122 of the mesh structure 123, but does not affect the opening 122 of the mesh structure 123. Axial deformation capacity and bending capacity.

The distal end of the adjustment part 120 is fixedly connected with the support part 110 . Specifically, a hollow snare structure is sleeved on the outer edge of the distal end of the elastic body 123 , and the snare structure is fixedly sleeved on the support portion 110 . The snare structure at the distal end 121a (for example, the head at the distal end 121a in FIG. 8 ) and the support part 110 are fixed on the support part 110 by common detachable or non-detachable connection methods such as welding, bonding, threaded connection, crimping, and bolt locking. Together, for example, welded connections can preferably be used.

Referring to FIG. 12 and FIG. 13 , the clamping part 130 includes at least two pliers arms 131 , generally at least one set of pliers arms 131 , and each set of pliers arms 131 includes two pliers arms 131 arranged symmetrically with respect to the adjustment part 120 , The clamping portion 130 in the figure includes a set of tong arms 131. It should be known that this is only used as an example, and those of ordinary skill in the art can select the appropriate number of tong arms 131 according to needs, such as two or more sets of tong arms . The driving part 140 is respectively connected with each pliers arm 131 , for example, the driving part 140 is respectively connected with two pliers arms 131 in a group of pliers arms 131 to drive each pliers arm 131 to rotate around the adjustment part 120 . It can be understood that three or more forceps arms 131 can also be provided in each group according to needs, for example, three leaflets of the tricuspid valve can be clamped by using three forceps arms 131 that can be opened and closed relatively. To treat tricuspid regurgitation.

In the delivery state, the driving part 140 drives the forceps arm 131 to close around the adjustment part 120, thereby reducing the outer diameter of the valve clamping device 100 and facilitating delivery; after the valve clamping device 100 is deployed in the body, the driving part 140 drives the forceps arm 131 to close the valve The leaflet is clamped between the forceps arm 131 and the adjustment part 120 to realize the clamping of the leaflet.

In a preferred implementation of this embodiment, the valve clamping device 100 further includes a gripping portion, which generally includes at least one set of gripping arms 151, and each set of gripping arms 151 includes two arms symmetrically arranged relative to the adjusting portion 120. A gripping arm 151, the gripping portion (such as the gripping arm 151) is located between the clamping portion 130 (such as the clamp arm 131) and the adjusting portion 120 and can be opened or closed relative to the regulating portion 120, the gripping portion and the clamping When the parts 130 are unfolded, the gripping part is at least partially accommodated on the inner surface of the clamping part 130 . Of course, three or more grasping arms 151 can also be provided in each group as required, so as to cooperate with the forceps arms 131 to realize the clamping function.

In the delivery state, the grasping portion is at least partially accommodated in the inner surface of the clamping portion 130, that is, the grasping arm 151 is at least partially accommodated in the inner surface of the forceps arm 131, thereby reducing the outer diameter of the valve clamping device 100 and facilitating Delivery; after the forceps arm 131 cooperates with the grasping arm 151 to clamp the leaflet, the concave inner surface can increase the contact area between the forceps arm 131 and the leaflet, and make the grasping arm 151 press the leaflet into the forceps arm 131 In the inner surface, the clamping force on the leaflet is increased.

Still referring to FIG. 12 and FIG. 13 , the valve clamping device 100 further includes a base 160 fixedly connected to the supporting part 110 , and the clamping part 130 is rotatably connected to the base 160 . Specifically, the proximal end of the base 160 is fixedly connected to the distal end 121a of the support part 110. It should be noted that this part is defined as the term "base" for the convenience of explanation here, and the structure that realizes the function of the base 160 can also be The distal end of the support part 110 is an integral structure formed with the support part 110, so defining the term "base" should not limit the scope of the present application. Each pliers arm 131 in each group is connected together on the base 160 through a pivot 132 , so that under the drive of the driving part 140 , each pliers arm 131 cooperates with each other to expand and close around the adjustment part 120 together.

Still referring to Fig. 12 and Fig. 13, the driving part 140 includes: a driving shaft 141, a connecting seat 142 and two connecting rods 143; wherein, one end of each connecting rod 143 is connected to the clamping part 130, and the other end is pivotally connected to the connecting seat 142 One end of the drive shaft 141 is connected to the connecting seat 142, and the other end is movably worn in the base 160. Specifically, one end of each connecting rod 143 is connected to a pliers arm 131, and the other end is connected to the connecting seat 142 through a pivot 144, that is, each pliers arm 131 is rotatably connected to the drive shaft 141 through the connecting rod 143 on the corresponding side. The far end of the connecting seat 142. The driving shaft 141 movably passes through the base 160 . When the driving shaft 141 slides axially relative to the base 160 , the connecting rod 143 rotates and drives the pliers arm 131 to open and close relative to the base 160 .

Specifically, the driving part 140 includes at least one set of connecting rods 143, and the number of the connecting rods 143 is set in a one-to-one correspondence with the setting of the pliers arms 131. For example, if two pliers arms 131 are used in the figure, two matching working Connecting rod 143 . The distal end of the connecting rod 143 is rotatably connected to the connection seat 142 at the far end of the drive shaft 141 by rotating a pin or a bolt 144 or the like. When the drive shaft 141 slides axially relative to the base 160 toward the distal end, it drives the connecting rod 143 to move. Under the pull of the connecting rod 143 , the forceps arm 131 rotates around the pin hole 144 and opens relative to the base 160 . When the drive shaft 141 slides proximally relative to the base 160 in the axial direction, the connecting rod 143 pulls the forceps arm 131 to rotate around the pin hole 144 and close relative to the base 160 .

The connecting seat 142 is fixedly arranged on the distal end of the driving shaft 141 by means of welding or the like, and the connecting seat 142 is provided with a pair of pins. The pin hole is used to hinge the connecting rod 143 through the pin 144 , and the other end of the connecting rod 143 is connected to the pliers arm 131 , so as to realize the opening and closing of the pliers arm 131 relative to the base 160 . The shape of the connecting seat 142 is any structure such as hemisphere, spherical cap or bullet, so as to make the valve clamping device 100 easier to push in the body. The driving shaft 141 and the connecting seat 142 can be an integral structure or a non-integral structure. In order to ensure the safety after implantation, the drive shaft 141 and the connecting seat 142 are made of biocompatible materials such as polyester, silicone resin, stainless steel, cobalt alloy, cobalt-chromium alloy or titanium alloy, preferably stainless steel with high hardness. or cobalt chrome.

Preferably, as shown in FIG. 12 , the valve clamping device 100 further includes a locking portion 170 disposed in the base 160 , and the locking portion 170 limits the relative movement between the driving shaft 141 and the base 160 . When in the delivery state, the locking part 170 restricts the relative movement between the drive shaft 141 and the base 160, thereby ensuring that the clamping part 130 remains closed relative to the adjusting part 120 and the supporting part 110, and avoids accidental deployment of the clamping part 130; After reaching near the mitral valve, unlock the restriction of the locking part 170 on the driving shaft 141 , and the clamping part 130 can be driven by the driving part 140 to expand relative to the adjusting part 120 and the supporting part 110 and support the valve leaflet. Any existing suitable locking portion can be used, and will not be repeated here.

Referring to Fig. 14 and Fig. 15, the valve clamping system of this embodiment includes the above-mentioned valve clamping device 100, and a delivery device 200, wherein the delivery device 200 includes: a push shaft 210 with a certain axial length and movably worn on The mandrel (not shown in the figure) in the push shaft 210 is detachably connected between the push shaft 210 and the support part 110, and the mandrel is connected with the drive part 140 for driving the expansion of the clamping part 130 relative to the support part 110 and closed. In this embodiment, the proximal end of the drive shaft 141 is provided with an external thread, and the mandrel is screwed to the drive shaft 141 , so that the axial movement of the drive shaft 141 is controlled by the mandrel outside the body of the patient. It should be known that what is listed here is only a part of the structure of the delivery device, other parts can adopt any existing suitable structure, and will not be repeated here.

Specifically, the proximal outer wall of the support part 110 is symmetrically provided with at least one locking position 114 communicating with the lumen of the support part 110, and a fixing part 220 is provided at the distal end of the pushing shaft 210. The fixing part 220 includes two branches, each branch The end is the raised card platform 221. In a natural state, both branches point to the central axis of the fixing member 220 . When assembling, insert the fixing part 220 into the supporting part 110, and then insert the mandrel of the conveying device 200 into the pushing shaft 210 until the mandrel is inserted into the fixing part 220, and the two branches of the fixing part 220 are lifted outwards, and the branches The clamping platform 221 at the end is snapped into the two clamping positions 114 of the supporting part 110 , so as to connect the supporting part 110 with the fixing part 220 , that is, connect the valve clamping device 100 and the delivery device 200 . When the mandrel is withdrawn from the fixing part 220 and the push shaft 210, the two branches return to the inward natural state, and the clamping table 221 is separated from the clamping position 114 of the support part 110, so that the valve clamping device 100 and the delivery device 200 Disconnect between. The fixing member 220 is made of nickel titanium and other materials with certain hardness and elasticity. The push shaft 210 can adopt a multi-layer composite pipe body. The mandrel is made of stainless steel.

A through hole is provided inside the supporting portion 110 as the passing channel 113 of the driving shaft 141 , and the driving shaft 141 is slidably inserted in the passing channel 113 of the supporting portion 110 in the axial direction. The proximal end of the drive shaft 141 is provided with an external thread for connecting with the mandrel of the delivery device 200, so that the axial movement of the drive shaft 141 is controlled by the mandrel. After the clamping part 130 and the grasping part 150 cooperate and clamp the valve tissue, the mandrel drives the drive shaft 141 to move proximally in the axial direction, and the drive shaft 141 drives the connecting rod 143 to rotate, and the connecting rod 143 drives the forceps arm 131 to face each other. Close up on the supporting part 110 until the forceps arm 131 is completely closed relative to the supporting part 110, so that the valve clamping device 100 is in a closed state and falls below the valve. Afterwards, the connection between the mandrel and the drive shaft 141 can be released, the mandrel is withdrawn from between the fixing parts 220, and the clamp table 221 is separated from the clamping position 114 of the support part 110, thereby realizing the valve clamping device 100 and the delivery device 200 relief. In the process of release, since the joint of the valve clamping device 100 and the delivery device 200 (that is, the release point) is located in the adjustment part 120 of the valve clamping device 100, and the proximal end of the adjustment part 120 is provided with an open opening 122 Therefore, there is no part that can hook the card platform 221 at the branch end of the fixing member 220 , which facilitates the release of the valve clamping device 100 . In addition, the release point is located inside the adjustment part 120 and is not directly washed by the blood, so that the mechanism failure of the release point can be avoided, and the risk of thrombus formation can also be reduced.

Referring to Fig. 16-Fig. 20, taking the antegrade approach and repair of the mitral valve through the left atrium as an example, the use process of the valve clamping device 100 of the present application is explained:

Step 1: As shown in FIG. 16 , push the drive shaft 141 and the valve clamping device 100 connected to it from the left atrium 2 through the guide device (not shown in the figure) such as an adjustable curved sheath, and pass through the mitral valve 1 reach the left ventricle 3;

Step 2: adjust the valve clamping device 100 to approach the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve 1;

Step 3: As shown in Figure 17, unlock the locking part in the base 160, pull the mandrel and the drive shaft 141 to the proximal end, drive the forceps arm 131 to open relative to the support part 110, and adjust the direction of the forceps arm 131, at this time The relative position of the forceps arm 131 and the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve 1 can be observed through X-ray equipment, so that the forceps arm 131 is perpendicular to the line of apposition of the mitral valve 1;

Step 4: As shown in Figure 18, withdraw the entire valve clamping device 100 proximally, so that the forceps arms 131 support the valve leaflet 1 on the side of the left ventricle 3, release the grasping arms 151 on both sides, and the grasping arms 151 on each side The holding arm 151 presses the leaflet 1 on the atrium side and cooperates with the forceps arm 131 on this side to fix the leaflet 1, so as to realize the complete clamping of the leaflet 1;

Step 5: As shown in Figure 19, when the anterior leaflet 1a and the posterior leaflet 1b of the mitral valve 1 are respectively clamped between a pair of forceps arms 131 and a grasping arm 151, push the mandrel and the drive shaft distally 141, thereby driving the clamp arm 131 to close;

Step 6: Release the threaded connection between the mandrel and the drive shaft 141, and withdraw the mandrel, the two branches of the fixing part 220 return to the state of moving closer to the central axis, and the clamp table 221 is in the clamping position 114 of the self-supporting part 110 Separated, the connection between the valve clamping device 100 and the delivery device 200 is released, and then the delivery device 200 is withdrawn from the body to obtain the implanted state as shown in Figure 20. The anterior leaflet 1a and posterior leaflet 1b are pulled toward each other, resulting in a bi-orificated mitral valve, completing the edge-to-edge repair of the mitral valve.

After the valve clamping device 100 is implanted, the elastic regulating part 120 fills between the anterior leaflet 1a and the posterior leaflet 1b of the clamped mitral valve 1, and abuts against the forceps arm 131. The elastic body of the regulating part 120 123 (such as a mesh structure or porous structure, etc.) has a buffering effect on the pulsating valve leaflet 1, so that the pulling degree of the valve leaflet 1 by the valve clamping device 100 can be adjusted to avoid damage to the valve leaflet 1; in addition, the elastic body 123 can be squeezed and deformed following the pulsation of the leaflet 1, and the generated elastic force pushes the part of the leaflet 1 close to the elastic body 123 away from the base 160. The axial movement of 123 toward the proximal end is no longer restricted, and the clamping angle between the anterior leaflet and the posterior leaflet of the mitral valve is smaller than the opening angle between the forceps arms 131, which can reduce the impact of the valve clamping device 100 on the valve leaflet 1. The pulling of the valve clamping device 100 keeps the valve leaflet 1 within a reasonable range; in addition, the elastic body 123 can buffer the direct washing of the blood flow to the inside of the valve clamping device 100, avoiding the valve clamping device 100. 100 is subject to the continuous washing of blood and falls off, which can also prevent blood from stagnating and forming thrombus at the dead angle between the clamping parts 130 of the valve clamping device 100 (at C in FIG. 5 ); in addition, the elastic body 123 is under the pressure of the valve. When it works, it will produce a certain degree of deformation, and the degree of deformation will increase with the increase of the pressure, so as to prevent the elastic body 123 from being squeezed by the forceps arm 131 to act on the forceps arm 131 after the valve leaflet 1 is grasped. , to ensure that the gripping effect of the valve leaflet 1 by the valve clamping device 100 after the release is consistent with that before the release.

Referring to FIGS. 21-23 , compared with the valve clamping device of the first embodiment, the mesh structure of the adjustment part 320 of the valve clamping device 300 according to the second embodiment of the present invention is located at all mesh wires 324 of the distal end 321 The support portion 310 is fixedly sleeved on. That is to say, the two ends 322 and 321 of the adjustment part 320 are open structures without heads, and the adjustment part 320 directly connects the mesh wire 324 at the far end 321 of the adjustment part 322 by welding, bonding, crimping, etc. It is fixed on the support part 310 in a non-detachable connection, and in this embodiment, it is preferably welded.

The opening or closing of the clamping part 330 (such as the forceps arm) rotates around the pivot 332 (such as a pin) near the distal end of the adjusting part 320 . When the clamping portion 330 is closed, the closer to the pivot 332 , the smaller the space. When the valve leaflets are clamped by the clamping part 330, some of the valve leaflets 1 will fill and accumulate in the space at D, which will not only affect the closing of the valve clamping device, but also when the filling of the valve leaflets 1 at this location cannot be found in time, When the valve clamping device is forcibly closed, the forceps arms will cause serious damage to the valve leaflet 1 there. In this embodiment, since the distal end 321 of the adjustment part 320 is also an open structure without a head, the adjustment part 320 can better conform to the deformation of the valve leaflet 1 during the closing process of the valve clamping device 300 . At the same time, since the adjustment part 320 reduces the hard sealing head, the space there is increased, which is beneficial for the entire valve clamping device 300 to close better after the valve leaflet 1 is grasped.

Referring to FIG. 24A , compared with the valve clamping device of the first embodiment, at least part of the outer surface of the mesh structure of the regulating portion 420 of the valve clamping device 400 according to the third embodiment of the present invention is coated. In addition, a coating can also be applied on at least part of the outer surfaces of the clamping portion 430 and the gripping portion 450 . The coating can be a woven mesh structure with multiple mesh holes. The regulating part 420 , the clamping part 430 and the grasping part 450 after film coating have higher biocompatibility and enhanced frictional force, so the clamping effect on the leaflet is better.

For example, referring to FIG. 24B , the grasping arm 451 and the forceps arm 431 are respectively covered with a first film and a second film, and the outside of the elastic body of the adjustment part 420 is covered with a third film. The relationship between the porosity of the three is: the porosity of the third coating<the porosity of the first coating<the porosity of the second coating. The opening ratio refers to the percentage of the opening area to the entire coating area. The opening ratio of the second coating is larger, so that the second coating has better elasticity and elongation than the first coating. When the forceps arm covered with the second coating is opened and closed relative to the fixed base , the second coating can produce corresponding elastic deformation following the opening and closing of the pliers arms, and the second coating is always attached to the pliers arms. The opening ratio of the third coating is the smallest, so that the elastic body can basically block the passage of blood.

The mesh holes on the first covering film and the second covering film can pass blood and prevent thrombus from passing through, and the mesh holes on the third covering film can pass neither blood nor thrombus. The first coating can allow blood to permeate through without affecting the normal flow of blood from the left atrium to the left ventricle, avoiding blood stagnation in the left atrium, thereby reducing the damage of blood pressure to the cavity of the left atrium; the first coating can also The contact area between the grasping arm and the blood is increased to buffer the inflowing blood flow, so as to avoid as much as possible the inflowing blood flow impacting the valve clamping device and causing the grasping arm to deform and cause slippage. The second membrane can make blood flow in the left atrium and between the left ventricle normally, thereby reducing the blood pressure difference between the left atrium and the left ventricle; The thrombus inside the valve clamping device is blocked and stays in the valve clamping device, preventing the thrombus from entering the left ventricle and entering the blood circulation of the human body to induce stroke.

The elastic body with the third coating not only increases biocompatibility, avoids tissue allergies and inflammatory reactions, and improves product safety, but more importantly, the elastic body with the third coating can also form an artificial The barrier blocks the thrombus in the blood, closes the opening of the whole valve clamping device towards the atrium side, and prevents the blood from repeatedly scouring the inner dead corner of the valve clamping device to form a thrombus, thereby avoiding thrombus.

The first covering film, the second covering film and the third covering film can all be made of macromolecular materials such as polyethylene terephthalate, polypropylene, polytetrafluoroethylene, polyurethane, and the materials of the three can be the same or Can be different, in this embodiment, all three are made of PET.

Referring to Fig. 25A-Fig. 25C, compared with the valve clamping device of the first embodiment, the adjustment part 520 of the valve clamping device according to the fourth embodiment of the present invention has a free hanging end and a distal end cap 521, the free hanging There may be an opening 522 at the end, and the adjusting part 520 includes a plurality of first curved surfaces 520A and a plurality of second curved surfaces 520B, the first curved surfaces 520A and the second curved surfaces 520B are adjacent to each other and smoothly connected together, that is, the first curved surfaces 520A It is only adjacent to the second curved surface 520B, and the second curved surface 520B is only adjacent to the first curved surface 520A. The two opposite first curved surfaces 520A are respectively facing one arm of the forceps. The area of the second curved surface 520B is larger than that of the first curved surface 520A. area.

In this embodiment, the first curved surface 520A with a relatively small area is facing the forceps arm, and the second curved surface 520B with a relatively large area is smoothly connected between the two first curved surfaces 520A. , the first curved surface 520A of the adjustment part is squeezed by the forceps arm and the leaflet, and the adjustment part extends along the direction of the second curved surface 520B, and gradually fits on the leaflet, thereby better adapting to the shape of the leaflet and increasing the The contact area between the first curved surface 520A and the valve leaflets reduces the gap between the valve clamping device and the valve leaflets, slows down the blood flow and prevents the blood flow from scouring the valve clamping device. Preferably, the curvature of the first curved surface 520A may be greater than the curvature of the second curved surface 520B, so that the adjustment part presents a flat ellipsoid shape, so as to avoid affecting the closing of the pliers arms. Further, in this embodiment, when the forceps arms are closed, the first curved surface 520A of the regulating part is pressed by the pressure of the forceps arms and the leaflets when the forceps arms are closed, and the regulating part extends along the direction of the second curved surface 520B. The first end of the valve is open, and will not hook the distal end of the delivery system, thereby ensuring that the valve clamping device is detached from the connection of the delivery device of the valve clamping device in the event of any deformation of the adjustment part.

Referring to FIG. 26A and FIG. 26B , compared with the valve clamping device of the first embodiment, the structure of the adjusting part 620 of the valve clamping device 600 according to the fifth embodiment of the present invention is the same as that of the adjusting part 120 of the first embodiment. The difference lies in the manner in which the clamping part 630 cooperates with the gripping part 650 to grab the leaflet. In the fifth embodiment, the clamping part 630 includes a set of clamp arms 631 that can be expanded or closed relative to the supporting part 610 and the adjusting part 620, the gripping part 650 includes a pair of gripping arms 651, and the gripping part 650 is located Between the joint part 630 and the adjustment part 620.

During delivery, the clamping part 630, the grasping part 650 and the adjusting part 620 are all accommodated in the distal end of the delivery device 200, and the delivery device 200 is sent into the left ventricle through the transapical approach and then crosses the mitral valve orifice to reach Left atrium, retract the delivery device 200, so that the adjustment part 620 and the grasping part 650 gradually protrude from the delivery device 200 and are deployed in the left atrium; continue to withdraw the delivery device 200 until the clamping part 630 also protrudes from the delivery device 200 and unfolded in the left ventricle; then the clamping part 630 is pushed to the far end by the driving part, and the anterior leaflet and the posterior leaflet of the mitral valve are respectively supported on the inner surfaces of the two forceps arms 631 of the clamping part 630, and the proximal The end retracts the grasping part 650 and the adjusting part 620, that is, drives the grasping part 650 to move in the direction of the clamping part 630, thereby capturing the leaflet between the grasping part 650 and the clamping part 630, and then drives the clamping part 630 The joint part 630 is closed relative to the adjustment part 620 and the support part 610, so that the front leaf and the rear leaf are respectively fixed between a pincer arm 631 and a grasping arm 651 corresponding to the pincer arm 631, and then pushed to the distal end The delivery device 200 is until the valve clamping device 600 is gradually closed; the connection between the valve clamping device and the delivery device 200 is released, so that the valve clamping device is implanted on the mitral valve, and the anterior leaflet of the mitral valve and the The posterior lobes are drawn towards each other forming a bipodous structure.

It can be understood that the valve clamping system according to the present application includes any valve clamping device mentioned above and a delivery device capable of delivering the valve clamping device from outside the body to the vicinity of the mitral valve and clamping the leaflets. The above description about the valve clamping device is only used as an example, and is not a limitation to the present application. The valve clamping device obtained by those of ordinary skill in the art based on the teaching of the application and the valve clamping system comprising the valve clamping device are all Within the protection scope of this application.

It should be noted that in this article, relative terms such as "first" and "second" are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply these No such actual relationship or order exists between entities or operations. Furthermore, the term "comprises", "comprises" or any other variation thereof is intended to cover a non-exclusive inclusion such that a process, method, article, or apparatus comprising a set of elements includes not only those elements, but also includes elements not expressly listed. other elements of or also include elements inherent in such a process, method, article, or device. Without further limitations, an element defined by the phrase "comprising a ..." does not exclude the presence of additional identical elements in the process, method, article or apparatus comprising said element.

The above descriptions are only specific embodiments of the present invention, so that those skilled in the art can understand or implement the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Accordingly, the present invention will not be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features claimed herein.

Claims (19)

1. A valve clamping device, characterized in that, comprising: a support portion, the support portion includes a connecting end and a free end disposed opposite to each other; A hollow adjustment part, at least a part of the support part is set in the adjustment part, one end of the adjustment part is sleeved outside the connection end and connected with the support part, and the free end of the support part is located at the inside the regulating part, and the free end is used for detachable connection with the conveying device, and the other end of the regulating part is freely suspended; A clamping part, the clamping part is surrounded by the outer side of the adjustment part; A driving part, the driving part is connected with the clamping part to drive the clamping part to expand or close around the adjusting part. 2. The valve clamping device according to claim 1, wherein the adjustment part comprises an elastic body, one end of the elastic body is connected to the support part, and the other end of the elastic body has an opening and is free. dangling. 3. The valve clamping device according to claim 2, wherein the size of the opening is smaller than or equal to the size of the free end. 4 . The valve clamping device according to claim 2 , wherein a hollow snare structure is sheathed on the proximal edge of the elastic body to form the opening. 5 . The valve clamping device according to claim 2 , wherein the proximal edge of the elastic body encloses the opening. 6 . 6 . The valve clamping device according to claim 2 , wherein the elastic body is at least one selected from a network structure, a frame structure, a dense structure or a porous structure. 7. The valve clipping device according to claim 6, wherein when the elastic body is the mesh structure or the frame structure, at least part of the outer surface of the elastic body is covered with a film. 8. The valve clipping device according to claim 6, wherein when the elastic body is the mesh structure or the frame structure, the elastic body is woven or cut from a shape memory material. 9. The valve clamping device according to claim 8, characterized in that, when the elastic body is the mesh structure, the mesh wires of the mesh structure are bent back at the proximal end to form the proximal end edge. 10. The valve clamping device according to claim 8, wherein when the elastic body is the frame structure, the adjacent struts of the frame structure are spaced from each other or cross-linked, and the frame The struts of the structure converge at the proximal end to form the proximal edge. 11. The valve clamping device according to claim 8, characterized in that, when the elastic body is the dense structure, the dense structure is silicon colloid; when the elastic body is the porous structure, The porous structure is a sponge; the dense structure or the proximal edge of the porous structure forms the opening. 12. The valve clamping device according to claim 2, characterized in that, the distal end of the elastic body is fixedly sleeved on the support part, or the distal edge of the elastic body is sleeved with a hollow A snare structure, the snare structure is fixedly sleeved on the support part. 13. The valve clamping device according to claim 1, wherein the clamping part comprises at least two forceps arms, and the at least two forceps arms are arranged symmetrically with respect to the adjusting part, and the driving part respectively connected with each of the pliers arms to drive each of the pliers arms to rotate around the adjustment portion. 14. The valve clamping device according to claim 13, wherein the adjusting part comprises a plurality of first curved surfaces and a plurality of second curved surfaces, the first curved surfaces and the second curved surfaces are adjacent to each other, The two first curved surfaces opposite to each other face one of the pliers arms, and the area of the second curved surface is larger than that of the first curved surface. 15. The valve clamping device according to any one of claims 1 to 13, characterized in that, the valve clamping device further comprises a grasping part, and the grasping part is arranged on the clamping part and the clamping part. The adjustment parts can be opened or closed relative to the adjustment part. When both the gripping part and the clamping part are unfolded, the gripping part is at least partially accommodated on the inner surface of the clamping part. 16. The valve clamping device according to any one of claims 1 to 13, characterized in that, the valve clamping device further comprises a base fixedly connected to the support part, and the clamping part is rotatably connected to on the base. 17. The valve clamping device according to claim 16, wherein the driving part comprises: a driving shaft, a connecting seat and at least two connecting rods; wherein, one end of each connecting rod is connected to the clamping part The other end is pivotally connected to the connecting seat; one end of the drive shaft is connected to the connecting seat, and the other end is movably worn in the base. 18. The valve clamping device according to claim 17, characterized in that, the valve clamping device further comprises a locking part provided in the base, and the locking part restricts the driving shaft from the base. The relative motion of the seat. 19. A valve clamping system, characterized in that it comprises the valve clamping device according to any one of claims 1 to 18, and a delivery device, the delivery device comprising: a push shaft with a certain axial length and a movable The mandrel installed in the push shaft is detachably connected between the push shaft and the support part, the mandrel is connected with the driving part, and is used to drive the clamping part relative to the The opening and closing of the above-mentioned supporting part.

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