CN111836819A - 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用 - Google Patents
一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用 Download PDFInfo
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- CN111836819A CN111836819A CN201980017096.3A CN201980017096A CN111836819A CN 111836819 A CN111836819 A CN 111836819A CN 201980017096 A CN201980017096 A CN 201980017096A CN 111836819 A CN111836819 A CN 111836819A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明提供了一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用，具体涉及式(I)所示化合物、其异构体、水合物、溶剂化物、其药学上可接受的盐及其前药，其制备方法及其在制备作为激酶抑制剂的药物中的应用。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810510208 | 2018-05-24 | ||
| CN2018105102086 | 2018-05-24 | ||
| CN2018115258245 | 2018-12-13 | ||
| CN201811525824 | 2018-12-13 | ||
| PCT/CN2019/088316 WO2019223777A1 (zh) | 2018-05-24 | 2019-05-24 | 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111836819A true CN111836819A (zh) | 2020-10-27 |
Family
ID=68615992
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201980017096.3A Pending CN111836819A (zh) | 2018-05-24 | 2019-05-24 | 一种含有芳胺基取代的吡咯并嘧啶类化合物、制备方法及其应用 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN111836819A (zh) |
| WO (1) | WO2019223777A1 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116239597A (zh) * | 2021-12-07 | 2023-06-09 | 中国科学院上海药物研究所 | 一种嘧啶并吡咯类衍生物及其药用组合物和应用 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220097305A (ko) * | 2020-12-29 | 2022-07-07 | 주식회사 비투에스바이오 | 헤테로아릴 유도체 화합물 및 이의 용도 |
| WO2023041071A1 (zh) * | 2021-09-18 | 2023-03-23 | 山东新时代药业有限公司 | 一种egfr抑制剂及其制备方法和用途 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105150A (zh) * | 2008-05-21 | 2011-06-22 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
| CN103153064A (zh) * | 2010-10-14 | 2013-06-12 | 阿里亚德医药股份有限公司 | 抑制egfr导致的癌症中细胞增殖的方法 |
| US20130225527A1 (en) * | 2008-05-21 | 2013-08-29 | Ariad Pharmaceuticals, Inc. | Phosphorus Derivatives as Kinase Inhibitors |
| US20140066406A1 (en) * | 2008-05-21 | 2014-03-06 | Ariad Pharmaceuticals, Inc. | Phosphorus Derivatives as Kinase Inhibitors |
| CN105330698A (zh) * | 2014-07-04 | 2016-02-17 | 南京明德新药研发股份有限公司 | 螺环芳基磷氧化物和硫化物 |
| CN106220608A (zh) * | 2016-07-25 | 2016-12-14 | 张柏 | 二苯氨基嘧啶及三嗪化合物、其药用组合物及用途 |
| CN109851638A (zh) * | 2018-02-07 | 2019-06-07 | 深圳市塔吉瑞生物医药有限公司 | 取代的二氨基嘧啶化合物 |
-
2019
- 2019-05-24 WO PCT/CN2019/088316 patent/WO2019223777A1/zh active Application Filing
- 2019-05-24 CN CN201980017096.3A patent/CN111836819A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105150A (zh) * | 2008-05-21 | 2011-06-22 | 阿里亚德医药股份有限公司 | 用作激酶抑制剂的磷衍生物 |
| US20130225527A1 (en) * | 2008-05-21 | 2013-08-29 | Ariad Pharmaceuticals, Inc. | Phosphorus Derivatives as Kinase Inhibitors |
| US20140066406A1 (en) * | 2008-05-21 | 2014-03-06 | Ariad Pharmaceuticals, Inc. | Phosphorus Derivatives as Kinase Inhibitors |
| CN103153064A (zh) * | 2010-10-14 | 2013-06-12 | 阿里亚德医药股份有限公司 | 抑制egfr导致的癌症中细胞增殖的方法 |
| CN105330698A (zh) * | 2014-07-04 | 2016-02-17 | 南京明德新药研发股份有限公司 | 螺环芳基磷氧化物和硫化物 |
| CN106220608A (zh) * | 2016-07-25 | 2016-12-14 | 张柏 | 二苯氨基嘧啶及三嗪化合物、其药用组合物及用途 |
| CN109851638A (zh) * | 2018-02-07 | 2019-06-07 | 深圳市塔吉瑞生物医药有限公司 | 取代的二氨基嘧啶化合物 |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116239597A (zh) * | 2021-12-07 | 2023-06-09 | 中国科学院上海药物研究所 | 一种嘧啶并吡咯类衍生物及其药用组合物和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2019223777A1 (zh) | 2019-11-28 |
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