CN111714399B - Whitening, antibacterial and cutin-removing hand sanitizer and preparation method thereof - Google Patents
Whitening, antibacterial and cutin-removing hand sanitizer and preparation method thereof Download PDFInfo
- Publication number
- CN111714399B CN111714399B CN202010725502.6A CN202010725502A CN111714399B CN 111714399 B CN111714399 B CN 111714399B CN 202010725502 A CN202010725502 A CN 202010725502A CN 111714399 B CN111714399 B CN 111714399B
- Authority
- CN
- China
- Prior art keywords
- parts
- whitening
- hand sanitizer
- antibacterial
- exfoliating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000002087 whitening effect Effects 0.000 title claims abstract description 56
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- 239000000049 pigment Substances 0.000 claims abstract description 44
- 230000003750 conditioning effect Effects 0.000 claims abstract description 43
- 239000002028 Biomass Substances 0.000 claims abstract description 31
- 239000002994 raw material Substances 0.000 claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 57
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 50
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- 239000000203 mixture Substances 0.000 claims description 25
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 25
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 239000008367 deionised water Substances 0.000 claims description 21
- 229910021641 deionized water Inorganic materials 0.000 claims description 21
- 239000000706 filtrate Substances 0.000 claims description 21
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 18
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 18
- 229930182490 saponin Natural products 0.000 claims description 18
- 150000007949 saponins Chemical class 0.000 claims description 18
- 239000000341 volatile oil Substances 0.000 claims description 18
- 238000000502 dialysis Methods 0.000 claims description 16
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 16
- 238000001914 filtration Methods 0.000 claims description 16
- 238000004108 freeze drying Methods 0.000 claims description 16
- 238000002791 soaking Methods 0.000 claims description 16
- 238000003756 stirring Methods 0.000 claims description 12
- RGHNJXZEOKUKBD-SQOUGZDYSA-N Gluconic acid Natural products OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 claims description 10
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 claims description 10
- 239000012528 membrane Substances 0.000 claims description 10
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims description 9
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims description 9
- 241001116389 Aloe Species 0.000 claims description 9
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 9
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 claims description 9
- AFSDNFLWKVMVRB-UHFFFAOYSA-N Ellagic acid Chemical compound OC1=C(O)C(OC2=O)=C3C4=C2C=C(O)C(O)=C4OC(=O)C3=C1 AFSDNFLWKVMVRB-UHFFFAOYSA-N 0.000 claims description 9
- ATJXMQHAMYVHRX-CPCISQLKSA-N Ellagic acid Natural products OC1=C(O)[C@H]2OC(=O)c3cc(O)c(O)c4OC(=O)C(=C1)[C@H]2c34 ATJXMQHAMYVHRX-CPCISQLKSA-N 0.000 claims description 9
- 229920002079 Ellagic acid Polymers 0.000 claims description 9
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims description 9
- 244000269722 Thea sinensis Species 0.000 claims description 9
- 229930003268 Vitamin C Natural products 0.000 claims description 9
- 229930003427 Vitamin E Natural products 0.000 claims description 9
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 claims description 9
- 235000011399 aloe vera Nutrition 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 9
- 229960002852 ellagic acid Drugs 0.000 claims description 9
- 235000004132 ellagic acid Nutrition 0.000 claims description 9
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 9
- 239000000174 gluconic acid Substances 0.000 claims description 9
- 235000012208 gluconic acid Nutrition 0.000 claims description 9
- 239000007788 liquid Substances 0.000 claims description 9
- 229960002510 mandelic acid Drugs 0.000 claims description 9
- FAARLWTXUUQFSN-UHFFFAOYSA-N methylellagic acid Natural products O1C(=O)C2=CC(O)=C(O)C3=C2C2=C1C(OC)=C(O)C=C2C(=O)O3 FAARLWTXUUQFSN-UHFFFAOYSA-N 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 235000019154 vitamin C Nutrition 0.000 claims description 9
- 239000011718 vitamin C Substances 0.000 claims description 9
- 229940046009 vitamin E Drugs 0.000 claims description 9
- 235000019165 vitamin E Nutrition 0.000 claims description 9
- 239000011709 vitamin E Substances 0.000 claims description 9
- 241001313857 Bletilla striata Species 0.000 claims description 8
- 240000000950 Hippophae rhamnoides Species 0.000 claims description 8
- 235000003145 Hippophae rhamnoides Nutrition 0.000 claims description 8
- 241000169546 Lycium ruthenicum Species 0.000 claims description 8
- 235000007303 Thymus vulgaris Nutrition 0.000 claims description 8
- 239000003814 drug Substances 0.000 claims description 8
- 239000010642 eucalyptus oil Substances 0.000 claims description 8
- 229940044949 eucalyptus oil Drugs 0.000 claims description 8
- 239000000284 extract Substances 0.000 claims description 8
- 238000002156 mixing Methods 0.000 claims description 8
- 238000002390 rotary evaporation Methods 0.000 claims description 8
- 238000000967 suction filtration Methods 0.000 claims description 8
- 239000001585 thymus vulgaris Substances 0.000 claims description 8
- 238000001132 ultrasonic dispersion Methods 0.000 claims description 8
- 241001529744 Origanum Species 0.000 claims description 4
- 235000011203 Origanum Nutrition 0.000 claims description 4
- 230000001662 opsonic effect Effects 0.000 claims description 4
- 230000001105 regulatory effect Effects 0.000 claims description 4
- 241000580955 Sapindus mukorossi Species 0.000 claims description 2
- 240000002657 Thymus vulgaris Species 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 30
- 239000004094 surface-active agent Substances 0.000 abstract description 25
- 239000000419 plant extract Substances 0.000 abstract description 20
- 229940088594 vitamin Drugs 0.000 abstract description 17
- 229930003231 vitamin Natural products 0.000 abstract description 17
- 235000013343 vitamin Nutrition 0.000 abstract description 17
- 239000011782 vitamin Substances 0.000 abstract description 17
- 150000007524 organic acids Chemical class 0.000 abstract description 14
- 230000003020 moisturizing effect Effects 0.000 abstract description 9
- 239000002904 solvent Substances 0.000 abstract description 9
- 150000003722 vitamin derivatives Chemical class 0.000 abstract description 4
- 210000003491 skin Anatomy 0.000 description 45
- 230000003385 bacteriostatic effect Effects 0.000 description 17
- 238000004140 cleaning Methods 0.000 description 14
- 238000012360 testing method Methods 0.000 description 11
- 240000003377 Shepherdia canadensis Species 0.000 description 7
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 7
- 241000246358 Thymus Species 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000002040 relaxant effect Effects 0.000 description 7
- 238000013329 compounding Methods 0.000 description 6
- 239000003921 oil Substances 0.000 description 6
- 238000005406 washing Methods 0.000 description 6
- 230000006378 damage Effects 0.000 description 5
- 238000002474 experimental method Methods 0.000 description 5
- 239000004744 fabric Substances 0.000 description 5
- 239000011148 porous material Substances 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- 235000013628 Lantana involucrata Nutrition 0.000 description 4
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 4
- 235000006677 Monarda citriodora ssp. austromontana Nutrition 0.000 description 4
- 240000007673 Origanum vulgare Species 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229920000832 Cutin Polymers 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000000428 dust Substances 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
- 230000008020 evaporation Effects 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 235000005985 organic acids Nutrition 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 238000005202 decontamination Methods 0.000 description 2
- 230000003588 decontaminative effect Effects 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000035618 desquamation Effects 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- 210000004602 germ cell Anatomy 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 230000036564 melanin content Effects 0.000 description 2
- 239000007764 o/w emulsion Substances 0.000 description 2
- 238000011056 performance test Methods 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 239000012488 sample solution Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241001478750 Chlorophytum comosum Species 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 102000003839 Human Proteins Human genes 0.000 description 1
- 108090000144 Human Proteins Proteins 0.000 description 1
- 244000178870 Lavandula angustifolia Species 0.000 description 1
- 235000010663 Lavandula angustifolia Nutrition 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000219925 Oenothera Species 0.000 description 1
- 235000004496 Oenothera biennis Nutrition 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 239000003157 biological pigment Substances 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229950006191 gluconic acid Drugs 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 239000008233 hard water Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000001102 lavandula vera Substances 0.000 description 1
- 235000018219 lavender Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000002752 melanocyte Anatomy 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000344 non-irritating Toxicity 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a whitening, antibacterial and exfoliating hand sanitizer and a preparation method thereof, wherein the whitening, antibacterial and exfoliating hand sanitizer is prepared from the following raw materials in parts by weight: 5.5-8.5 parts of plant extract relieving factor, 1.5-4.5 parts of natural organic acid, 12-18 parts of bio-based surfactant, 5-8 parts of biomass pigment conditioning factor, 1-3 parts of natural vitamin and 83-100 parts of solvent. The whitening, antibacterial and exfoliating hand sanitizer takes various natural biological-based environment-friendly components as main raw materials, is mild and skin-friendly, has excellent moisturizing performance, can remove old cuticle of hands without damaging new skin, has remarkable whitening and antibacterial effects, and has a high application value of integrating multiple effects.
Description
Technical Field
The invention belongs to the technical field of hand sanitizer, and particularly relates to a whitening, antibacterial and exfoliating hand sanitizer and a preparation method thereof.
Background
The common hand sanitizer has the main function of cleaning and protecting the skin of hands. With the improvement of living standard, the demand of people for the quality and function diversification of the hand sanitizer is higher and higher. The currently marketed hand sanitizer products are various in variety and large in quality difference, and a part of the hand sanitizer products still mainly use a chemically synthesized surfactant, are strong in alkalinity and have certain stimulation harm to skin; many kinds only have cleaning effect, and the effect of moisturizing is relatively poor, and the function is single.
In summer, the ultraviolet rays are strong, the climate is hot and humid, the skin of people is very easy to sweat and generate oil, bacteria are bred, and the skin is also easy to be tanned, particularly, the skin of hands of people exposed for a long time is also often aged and thickened. Based on the above, the weak-acid hand sanitizer which takes plant extract relieving factors, bio-based surfactants and biomass pigment conditioning factors as main components, can keep moisture for a long time, removes old thick cuticle of hands without damaging new skin, has a remarkable whitening and bacteriostasis effect is developed, the variety and application range of the hand sanitizer are greatly expanded, and the weak-acid hand sanitizer has a wide market prospect.
Disclosure of Invention
This section is for the purpose of summarizing some aspects of embodiments of the invention and to briefly introduce some preferred embodiments. In this section, as well as in the abstract and the title of the invention of this application, simplifications or omissions may be made to avoid obscuring the purpose of the section, the abstract and the title, and such simplifications or omissions are not intended to limit the scope of the invention.
The present invention has been made keeping in mind the above and/or other problems occurring in the prior art.
Therefore, the invention aims to overcome the defects in the prior art and provide the skin-whitening, bacteriostatic and cutin-removing hand sanitizer.
In order to solve the technical problems, the invention provides the following technical scheme: a whitening, antibacterial and cutin-removing hand sanitizer is characterized in that: the whitening, antibacterial and exfoliating hand sanitizer comprises the following raw materials in parts by weight: 5.5-8.5 parts of plant extract relieving factor, 1.5-4.5 parts of natural organic acid, 12-18 parts of bio-based surfactant, 5-8 parts of biomass pigment conditioning factor, 1-3 parts of natural vitamin and 83-100 parts of solvent.
As a preferable scheme of the whitening, bacteriostatic and exfoliating hand sanitizer, the whitening, bacteriostatic and exfoliating hand sanitizer comprises the following components in percentage by weight: the plant extract relieving factor is a composition containing three or more of origanum essential oil, lavender essential oil, thyme essential oil, eucalyptus oil and cinnamon essential oil.
As a preferable scheme of the whitening, bacteriostatic and exfoliating hand sanitizer, the whitening, bacteriostatic and exfoliating hand sanitizer comprises the following components in percentage by weight: the natural organic acid is composition of mandelic acid, gluconic acid and ellagic acid.
As a preferable scheme of the whitening, bacteriostatic and exfoliating hand sanitizer, the whitening, bacteriostatic and exfoliating hand sanitizer comprises the following components in percentage by weight: the bio-based surfactant is a composition of tea saponin, soapberry saponin, isopropyl myristate and alkanolamide.
As a preferable scheme of the whitening, bacteriostatic and exfoliating hand sanitizer, the whitening, bacteriostatic and exfoliating hand sanitizer comprises the following components in percentage by weight: the preparation method of the biomass pigment conditioning factor comprises the following steps: drying the pigment-containing opsonic factor organisms in an oven at 27-32 ℃ for 3-5 h in advance, adding the dried pigment-containing opsonic factor organisms into a medicine crusher, fully crushing, soaking in 75-95% ethanol water solution, adding a small amount of baking soda, wherein the mass ratio of the pigment-containing opsonic factor organisms to the ethanol water solution to the baking soda is 1.5: 15-30: 0.1-0.2, uniformly mixing the whole system, soaking at-15 ℃ for 24 hours, and filtering to obtain a primary extracting solution; and (2) dialyzing and separating the primary extract obtained by filtering at room temperature by using a dialysis membrane with the molecular weight cutoff of 12000-16000 for 3-5 days, performing rotary evaporation and concentration treatment after dialysis, performing suction filtration by using filter paper with the pore diameter of 1-5 mu m, wherein the pump pressure is 0.02-0.06 MPa, freeze-drying the obtained filtrate, and performing ultrasonic dispersion on the filtrate in glycerol (the mass ratio of solid particles obtained after freeze-drying the filtrate to the glycerol is 1-2: 10) to obtain the biomass pigment conditioning factor.
As a preferable scheme of the whitening, bacteriostatic and exfoliating hand sanitizer, the whitening, bacteriostatic and exfoliating hand sanitizer comprises the following components in percentage by weight: the biological pigment-containing conditioning factor is a composition of three or more of chlorophytum comosum, aloe, rose, lycium ruthenicum, evening primrose, bletilla striata and sea buckthorn.
As a preferable scheme of the whitening, bacteriostatic and exfoliating hand sanitizer, the whitening, bacteriostatic and exfoliating hand sanitizer comprises the following components in percentage by weight: the natural vitamin is a composition of nicotinamide, vitamin E and vitamin C.
As a preferable scheme of the whitening, bacteriostatic and exfoliating hand sanitizer, the whitening, bacteriostatic and exfoliating hand sanitizer comprises the following components in percentage by weight: the solvent is a composition of deionized water and butanediol.
The invention further aims to overcome the defects in the prior art and provide a preparation method of the whitening, antibacterial and exfoliating hand sanitizer.
In order to solve the technical problems, the invention provides the following technical scheme: a preparation method of a whitening, antibacterial and exfoliating hand sanitizer comprises the following specific steps: stirring and dissolving 4-7 parts of butanediol, 2-3 parts of tea saponin, 4-6 parts of soapnut saponin, 3-4.5 parts of isopropyl myristate, 3-4.5 parts of alkanolamide and 39.5-46.5 parts of deionized water until the mixture is uniform and transparent, then slowly adding 5.5-8.5 parts of plant extract relieving factor, 5-8 parts of biomass pigment conditioning factor, 0.5-1.5 parts of mandelic acid, 0.5-1 part of gluconic acid and 0.5-2 parts of ellagic acid into the mixture, stirring the mixture for 18-22 min at 620-700 rpm by using a high-speed stirrer, then adding 39.5-46.5 parts of deionized water, 0.25-1 part of nicotinamide, 0.25-1 part of vitamin E and 0.5-1 part of vitamin C, continuously stirring the mixture for 13-17 min at 290-370 rpm, and adjusting the pH value to be between 5.8-6.5 by using a small amount of citric acid or sodium bicarbonate to obtain the uniform and transparent skin-whitening hand sanitizer.
The invention has the beneficial effects that:
(1) the whitening, antibacterial and exfoliating hand sanitizer disclosed by the invention adopts various natural biological-based environment-friendly components as main raw materials, is mild, skin-friendly, non-irritant, efficient and clean, reduces the occurrence of dry and desquamation phenomena of hand skin, is fine and rich in foam, has whitening and antibacterial effects while preserving moisture and removing old thick cuticle, and is particularly suitable for being used in summer, and the pH value of the hand sanitizer is weak acid and close to that of human skin. The whitening, antibacterial and exfoliating hand sanitizer disclosed by the invention achieves the functions of efficiently cleaning and removing old thick cuticles mainly through the compounding of the bio-based surfactant, natural vitamins and natural organic acid: one end of the bio-based surfactant molecule is hydrophilic, and the other end is hydrophobic, so that body surface stains such as dust, oil stain, cutin and the like can be emulsified into small microdroplets or stripped and surrounded, and the stains are conveniently removed; the natural vitamins and natural organic acids can mildly soften and remove part of cuticle and promote metabolism of hand skin, so that old thick cuticle and new skin are gradually separated, and the old thick cuticle and the new skin are cooperated with the deep penetration cleaning effect of the bio-based surfactant, so that the aged cuticle can be mostly removed, meanwhile, the delicate new cuticle is not damaged, and an ideal cleaning effect is achieved. Experiments prove that the reasonable compounding effect of the three components is far better than that of the method of removing any one of the three components, which indicates that the three components have a synergistic effect.
(2) The whitening, antibacterial and exfoliating hand sanitizer provided by the invention has the advantages that the addition of the plant extract relaxing factor, the natural organic acid and the bio-based surfactant unexpectedly endows the hand sanitizer with an antibacterial effect, and the effect is closely related to the damage of the natural volatile substances planted with the plant extract relaxing factor, the acidic microenvironment provided by the natural organic acid and the surface damage of the bio-based surfactant to germ cell membranes.
(3) The whitening effect of the whitening, antibacterial and exfoliating hand sanitizer provided by the invention on hands comes from the effects of plant extract relaxing factors, biomass pigment conditioning factors and natural vitamins: the plant extract soothing factor contains components capable of soothing and conditioning the water-oil balance of skin, which provides better conditions for the biomass pigment conditioning factor to exert the conditioning effect on the pigment of hand skin, and the inhibition effect of natural vitamins on melanin fully shows that the three components have the synergistic effect.
(4) The whitening, antibacterial and exfoliating hand sanitizer disclosed by the invention has the following effects that the moisturizing and moistening effects of the hand sanitizer are ensured by the solvent, the plant extract relieving factor, the bio-based surfactant and the biomass pigment conditioning factor: the solvent in reasonable proportion can provide sufficient moisture for skin and simultaneously slow down the evaporation of the moisture; the plant extract soothing factors and the bio-based surfactant can penetrate into the hand skin to retain the moisture of the hand skin, and are beneficial to the permeation and affinity of each effective component to the skin; the glycerol in the biomass pigment conditioning factor has the effect of absorbing moisture in the air. Thus, the moisturizing efficacy of the hand sanitizer is a result of the combined action of these four ingredients.
(5) According to the whitening, antibacterial and exfoliating hand sanitizer, deionized water is added twice during preparation, and natural vitamins are added subsequently, and experiments prove that only through the addition sequence and the proportion, the finally obtained hand sanitizer has an oil-in-water emulsion type, and only through the type, the whitening, antibacterial and exfoliating hand sanitizer can be more stable, various functions can be fully exerted, and otherwise, the effect is greatly reduced.
Detailed Description
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, specific embodiments thereof are described in detail below with reference to examples of the specification.
In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described and will be readily apparent to those of ordinary skill in the art without departing from the spirit of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
Furthermore, reference herein to "one embodiment" or "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment is included in at least one implementation of the invention. The appearances of the phrase "in one embodiment" in various places in the specification are not necessarily all referring to the same embodiment, nor are separate or alternative embodiments mutually exclusive of other embodiments.
In the present invention, the raw materials are not specifically described, and are all generally commercially available.
The moisture retention performance test of the invention:
the instrument comprises the following steps: skin moisture tester (Corneometer), skin moisture loss tester (Vapometer), delfisin technologies ltd, finland; a multifunctional vertical decontamination measuring machine, Shanghai Yinzui instrument and equipment Co., Ltd. And (4) moisture retention performance test: the moisturizing efficacy of the product and control samples over 1h of use was evaluated by the skin moisture content test (Corneometer), the skin moisture loss test (Vapometer); in the test, 10 women (dry or dry mixed skin population) aged 18-65 years are selected as test objects, the using amount is 0.1 g/person, the water temperature is 26 ℃ during hand washing, the women are washed clean by distilled water after 30s, the women are dipped in a paper towel for drying, and then a skin moisture tester (Corneometer) and a skin moisture loss tester (Vapometer) are respectively used for measuring the skin moisture content and the loss rate of the product before use and 1h after use, wherein 5 times of skin moisture tests are measured in each test area, and 3 times of the moisture loss tests are measured in each area.
The detergency test of the invention:
the adopted instrument is as follows: a multifunctional vertical decontamination measuring machine, Shanghai Yize instruments and Equipment Co., Ltd; the detergency test of the invention evaluates the detergency of the product to sebum and protein of a human body by a vertical detergency tester: cleaning human sebum and human protein dirty cloth by using the product, adding 1.5g of sample into 500mL of hard water (250mg/kg), pre-stirring and dispersing for 2min, then respectively adding 3 pieces of sebum dirty cloth and 3 pieces of protein dirty cloth, washing the dirty cloth with clear water after 10min, hanging and airing, and calculating the stain removal value of the sample by measuring the whiteness difference of the dirty cloth before and after cleaning:
cleaning power value is whiteness after washing-whiteness before washing
And (3) testing the antibacterial performance: the method is characterized in that the killing rate of escherichia coli and staphylococcus before and after hand washing is evaluated, an average value is taken by more than 10 (all people with oily or oil-mixed skin), the using amount is 0.1 g/person, and the water temperature is 26 ℃ during hand washing.
And (3) testing the whitening performance: and (4) measuring the melanin content in the melanocyte, and inspecting the whitening effect of the hand sanitizer. Taking melanoma cells of mice in logarithmic growth phase at 20 × 103The density of individual/well was plated in 6-well plates at 2mL per well (excluding blank), and after 24h incubation in the incubator, the culture medium was removed from the wells. DMEM is used as a solution to prepare sample solutions with certain concentrations respectively, 2mL of the sample solutions are added into each well to incubate for 24h, and 100 mu L of DMEM is used as a control group to replace the samples. The wells were removed of solution, washed 2 times with PBS and the cells were collected. Adding 1mL 10% DMSO (prepared by NaOH), shaking thoroughly, sealing, standing for 30min, and detecting absorbance at 470nm to obtain melanin content.
Example 1
The embodiment provides a preparation method of a whitening, bacteriostatic and exfoliating hand sanitizer, which comprises the following steps:
(1) drying aloe, lycium ruthenicum mill, bletilla striata and sea buckthorn (the mass ratio is 1.2:1.2:1:1.5) in an oven at 32 ℃ for 4 hours in advance, fully crushing in a medicine crusher, soaking in 95% ethanol water solution, adding a small amount of baking soda, the mass ratio of the pigment conditioning factor-containing organisms to the ethanol water solution to the baking soda is 1.5:22.5:0.15, uniformly mixing the whole system, soaking at-15 ℃ for 24 hours, and filtering to obtain a primary extracting solution;
dialyzing and separating the primary extract obtained by filtering at room temperature by using a dialysis membrane with the molecular weight cutoff of 16000 for 5 days, performing rotary evaporation and concentration treatment after dialysis is finished, performing suction filtration by using filter paper with the aperture of 5 mu m, wherein the pump pressure is 0.06MPa, performing freeze drying on the obtained filtrate, and performing ultrasonic dispersion on the obtained filtrate in glycerol (the mass ratio of solid particles obtained after freeze drying of the filtrate to the glycerol is 1.5:10) to obtain the biomass pigment conditioning factor;
(2) 5.5 parts of butanediol, 2.5 parts of tea saponin, 5 parts of soapberry saponin, 3.75 parts of isopropyl myristate, 3.75 parts of alkanolamide and 43 parts of deionized water are stirred and dissolved until uniform and transparent, then 2.5 parts of oregano essential oil, 2 parts of thyme essential oil, 2.5 parts of eucalyptus oil, 6.5 parts of biomass pigment conditioning factor, 1 part of mandelic acid, 0.75 part of gluconic acid and 1.25 parts of ellagic acid are slowly added into the mixture, and simultaneously a high-speed stirrer is used for stirring at 660rpm for 20min, at the moment, 43 parts of deionized water, 0.625 part of nicotinamide, 0.625 part of vitamin E and 0.75 part of vitamin C are added, the mixture is continuously stirred at 330rpm for 15min, and a small amount of citric acid or baking soda is used for regulating the pH value to be 6.0, so as to obtain uniform and viscous transparent liquid, namely the whitening and cutin-removing antibacterial hand sanitizer.
Comparative example 1
(1) Drying aloe, lycium ruthenicum mill, bletilla striata and sea buckthorn (the mass ratio is 1.2:1.2:1:1.5) in an oven at 32 ℃ for 4 hours in advance, fully crushing in a medicine crusher, soaking in 95% ethanol water solution, adding a small amount of baking soda, the mass ratio of the pigment conditioning factor-containing organisms to the ethanol water solution to the baking soda is 1.5:22.5:0.15, uniformly mixing the whole system, soaking at-15 ℃ for 24 hours, and filtering to obtain a primary extracting solution;
dialyzing and separating the primary extract obtained by filtering at room temperature by using a dialysis membrane with the molecular weight cutoff of 16000 for 5 days, performing rotary evaporation and concentration treatment after dialysis is finished, performing suction filtration by using filter paper with the pore diameter of 5 mu m, wherein the pump pressure is 0.06MPa, performing freeze drying on the obtained filtrate, and performing ultrasonic dispersion in glycerol (the mass ratio of solid particles obtained after freeze drying of the filtrate to the glycerol is 1.5:10) to obtain the biomass pigment conditioning factor.
(2) 5.5 parts of butanediol and 43 parts of deionized water are stirred and dissolved until the mixture is uniform and transparent, then 2.5 parts of origanum essential oil, 2 parts of thyme essential oil, 2.5 parts of eucalyptus oil, 6.5 parts of biomass pigment conditioning factor, 1 part of mandelic acid, 0.75 part of gluconic acid and 1.25 parts of ellagic acid are slowly added into the mixture, and the mixture is stirred for 20min at 660rpm by using a high-speed stirrer, at the moment, 43 parts of deionized water, 0.625 part of nicotinamide, 0.625 part of vitamin E and 0.75 part of vitamin C are added, the mixture is continuously stirred for 15min at 330rpm, and the pH value is adjusted to 6.0 by using a small amount of citric acid or baking soda, so that uniform and viscous transparent liquid, namely the whitening and cutin-removing antibacterial hand sanitizer (compared with the hand sanitizer in example 1, no bio-based surfactant is added).
Comparative example 2
(1) Drying aloe, lycium ruthenicum mill, bletilla striata and sea buckthorn (the mass ratio is 1.2:1.2:1:1.5) in an oven at 32 ℃ for 4 hours in advance, fully crushing in a medicine crusher, soaking in 95% ethanol water solution, adding a small amount of baking soda, the mass ratio of the pigment conditioning factor-containing organisms to the ethanol water solution to the baking soda is 1.5:22.5:0.15, uniformly mixing the whole system, soaking at-15 ℃ for 24 hours, and filtering to obtain a primary extracting solution;
dialyzing and separating the primary extract obtained by filtering at room temperature by using a dialysis membrane with the molecular weight cutoff of 16000 for 5 days, performing rotary evaporation and concentration treatment after dialysis is finished, performing suction filtration by using filter paper with the aperture of 5 mu m, wherein the pump pressure is 0.06MPa, performing freeze drying on the obtained filtrate, and performing ultrasonic dispersion on the obtained filtrate in glycerol (the mass ratio of solid particles obtained after freeze drying of the filtrate to the glycerol is 1.5:10) to obtain the biomass pigment conditioning factor;
(2) 5.5 parts of butanediol, 2.5 parts of tea saponin, 5 parts of soapberry saponin, 3.75 parts of isopropyl myristate, 3.75 parts of alkanolamide and 43 parts of deionized water are stirred and dissolved until uniform and transparent, then 2.5 parts of oregano essential oil, 2 parts of thyme essential oil, 2.5 parts of eucalyptus oil, 6.5 parts of biomass pigment conditioning factor, 1 part of mandelic acid, 0.75 part of gluconic acid and 1.25 parts of ellagic acid are slowly added into the solution, simultaneously a high-speed stirrer is used for stirring at 660rpm for 20min, 43 parts of deionized water is added at the moment, the solution is continuously stirred at 330rpm for 15min, and a small amount of citric acid or baking soda is used for adjusting the pH value to be 6.0 to obtain uniform and viscous transparent liquid, namely the bacteriostatic and cutin-removing hand sanitizer (compared with the solution in example 1, natural vitamin is not added).
Comparative example 3
(1) Drying aloe, lycium ruthenicum mill, bletilla striata and sea buckthorn (the mass ratio is 1.2:1.2:1:1.5) in an oven at 32 ℃ for 4 hours in advance, fully crushing in a medicine crusher, soaking in 95% ethanol water solution, adding a small amount of baking soda, the mass ratio of the pigment conditioning factor-containing organisms to the ethanol water solution to the baking soda is 1.5:22.5:0.15, uniformly mixing the whole system, soaking at-15 ℃ for 24 hours, and filtering to obtain a primary extracting solution;
dialyzing and separating the primary extract obtained by filtering at room temperature by using a dialysis membrane with the molecular weight cutoff of 16000 for 5 days, performing rotary evaporation and concentration treatment after dialysis is finished, performing suction filtration by using filter paper with the pore diameter of 5 mu m, wherein the pump pressure is 0.06MPa, performing freeze drying on the obtained filtrate, and performing ultrasonic dispersion in glycerol (the mass ratio of solid particles obtained after freeze drying of the filtrate to the glycerol is 1.5:10) to obtain the biomass pigment conditioning factor.
(2) 5.5 parts of butanediol, 2.5 parts of tea saponin, 5 parts of soapberry saponin, 3.75 parts of isopropyl myristate, 3.75 parts of alkanolamide and 43 parts of deionized water are stirred and dissolved until uniform and transparent, then 2.5 parts of oregano essential oil, 2 parts of thyme essential oil, 2.5 parts of eucalyptus oil and 6.5 parts of biomass pigment conditioning factor are slowly added into the mixture, a high-speed stirrer is used for stirring at 660rpm for 20min, at the moment, 43 parts of deionized water, 0.625 parts of nicotinamide, 0.625 parts of vitamin E and 0.75 parts of vitamin C are added, stirring is continued at 330rpm for 15min, and after the pH value is adjusted to be between 5.8 and 6.5 by using a small amount of citric acid or baking soda, uniform and viscous transparent liquid is obtained, namely the whitening and antibacterial exfoliating hand sanitizer (compared with the example 1, natural organic acid is not added).
Comparative example 4
(1) Drying aloe, lycium ruthenicum mill, bletilla striata and sea buckthorn (the mass ratio is 1.2:1.2:1:1.5) in an oven at 32 ℃ for 4 hours in advance, fully crushing in a medicine crusher, soaking in 95% ethanol water solution, adding a small amount of baking soda, the mass ratio of the pigment conditioning factor-containing organisms to the ethanol water solution to the baking soda is 1.5:22.5:0.15, uniformly mixing the whole system, soaking at-15 ℃ for 24 hours, and filtering to obtain a primary extracting solution;
dialyzing and separating the primary extract obtained by filtering at room temperature by using a dialysis membrane with the molecular weight cutoff of 16000 for 5 days, performing rotary evaporation and concentration treatment after dialysis is finished, performing suction filtration by using filter paper with the pore diameter of 5 mu m, wherein the pump pressure is 0.06MPa, performing freeze drying on the obtained filtrate, and performing ultrasonic dispersion in glycerol (the mass ratio of solid particles obtained after freeze drying of the filtrate to the glycerol is 1.5:10) to obtain the biomass pigment conditioning factor.
(2) 5.5 parts of butanediol, 2.5 parts of tea saponin, 5 parts of soapberry saponin, 3.75 parts of isopropyl myristate, 3.75 parts of alkanolamide and 43 parts of deionized water are stirred and dissolved until the mixture is uniform and transparent, then 6.5 parts of biomass pigment conditioning factor, 1 part of mandelic acid, 0.75 part of gluconic acid and 1.25 parts of ellagic acid are slowly added into the mixture, a high-speed stirrer is used for stirring at 660rpm for 20min, at the same time, 43 parts of deionized water, 0.625 part of nicotinamide, 0.625 part of vitamin E and 0.75 part of vitamin C are added, stirring is continued at 330rpm for 15min, and a small amount of citric acid or baking soda is used for regulating the pH value to be 6.0, so that uniform and viscous transparent liquid, namely the whitening and antibacterial exfoliating hand sanitizer (compared with the hand sanitizer in example 1, no plant extract relaxing factor is added).
Comparative example 5
(1) 5.5 parts of butanediol, 2.5 parts of tea saponin, 5 parts of soapberry saponin, 3.75 parts of isopropyl myristate, 3.75 parts of alkanolamide and 43 parts of deionized water are stirred and dissolved until uniform and transparent, then 2.5 parts of oregano essential oil, 2 parts of thyme essential oil, 2.5 parts of eucalyptus oil, 1 part of mandelic acid, 0.75 part of gluconic acid and 1.25 parts of ellagic acid are slowly added into the mixture, and the mixture is stirred for 20min at 660rpm by using a high-speed stirrer, at the moment, 43 parts of deionized water, 0.625 part of nicotinamide, 0.625 part of vitamin E and 0.75 part of vitamin C are added, the mixture is continuously stirred for 15min at 330rpm, and after the pH value is adjusted to be between 5.8 and 6.5 by using a small amount of citric acid or baking soda, a uniform and viscous transparent antibacterial liquid is obtained, namely the whitening and exfoliating hand sanitizer (compared with example 1, no biomass pigment conditioning factor is added).
Comparative example 6
(1) Drying aloe, lycium ruthenicum mill, bletilla striata and sea buckthorn (the mass ratio is 1.2:1.2:1:1.5) in an oven at 27-32 ℃ for 4 hours in advance, fully crushing in a medicine crusher, soaking in 75-95% ethanol water solution, adding a small amount of baking soda, the mass ratio of the pigment conditioning factor-containing organisms to the ethanol water solution to the baking soda is 1.5:22.5:0.15, uniformly mixing the whole system, soaking at-15 ℃ for 24 hours, and filtering to obtain a primary extracting solution;
and (2) dialyzing and separating the primary extract obtained by filtering at room temperature by using a dialysis membrane with the molecular weight cutoff of 12000-16000 for 3-5 days, performing rotary evaporation and concentration treatment after dialysis, performing suction filtration by using filter paper with the pore diameter of 1-5 mu m, wherein the pump pressure is 0.02-0.06 MPa, freeze-drying the obtained filtrate, and performing ultrasonic dispersion on the filtrate in glycerol (the mass ratio of solid particles obtained after freeze-drying the filtrate to the glycerol is 1.5:10) to obtain the biomass pigment conditioning factor.
(2) 5.5 parts of butanediol, 2.5 parts of tea saponin, 5 parts of soapberry saponin, 3.75 parts of isopropyl myristate, 3.75 parts of alkanolamide, 0.625 part of nicotinamide, 0.625 part of vitamin E, 0.75 part of vitamin C and 86 parts of deionized water are stirred and dissolved to be uniform and transparent, then 2.5 parts of origanum essential oil, 2 parts of thyme essential oil, 2.5 parts of eucalyptus oil, 6.5 parts of biomass pigment conditioning factor, 1 part of mandelic acid, 0.75 part of gluconic acid and 1.25 parts of ellagic acid are slowly added into the solution, and simultaneously a high-speed stirrer is used for stirring at 660rpm for 35min, and a small amount of citric acid or baking soda is used for regulating the pH value to be between 5.8 and 6.5, so as to obtain a uniform and viscous transparent liquid for whitening and exfoliating, namely the antibacterial hand washing liquid (compared with the example 1, the adding sequence of natural vitamins is advanced, and the deionized water is added at one time).
The results of the property measurements of the products obtained in example 1 and comparative examples 1 to 6 are shown in Table 1.
TABLE 1
The whitening, antibacterial and exfoliating hand sanitizer disclosed by the invention achieves the functions of efficiently cleaning and removing old thick cuticles mainly through the compounding of the bio-based surfactant, natural vitamins and natural organic acid: one end of the bio-based surfactant molecule is hydrophilic, and the other end is hydrophobic, so that body surface stains such as dust, oil stain, cutin and the like can be emulsified into small microdroplets or stripped and surrounded, and the stains are conveniently removed; the natural vitamins and natural organic acids can mildly soften and remove part of cuticle and promote metabolism of hand skin, so that old thick cuticle and new skin are gradually separated, and the old thick cuticle and the new skin are cooperated with the deep penetration cleaning effect of the bio-based surfactant, so that the aged cuticle can be mostly removed, meanwhile, the delicate new cuticle is not damaged, and an ideal cleaning effect is achieved. Experiments prove that the reasonable compounding effect of the three components is far better than that of the method of removing any one of the three components, which shows that the three components have the synergistic effect
The whitening, antibacterial and exfoliating hand sanitizer disclosed by the invention has the following effects that the moisturizing and moistening effects of the hand sanitizer are ensured by the solvent, the plant extract relieving factor, the bio-based surfactant and the biomass pigment conditioning factor: the solvent in reasonable proportion can provide sufficient moisture for skin and simultaneously slow down the evaporation of the moisture; the plant extract soothing factors and the bio-based surfactant can penetrate into the hand skin to retain the moisture of the hand skin, and are beneficial to the permeation and affinity of each effective component to the skin; the glycerol in the biomass pigment conditioning factor has the effect of absorbing moisture in the air. Thus, the moisturizing efficacy of the hand sanitizer is a result of the combined action of these four ingredients.
In conclusion, the whitening, antibacterial and exfoliating hand sanitizer disclosed by the invention adopts various natural biological-based environment-friendly components as main raw materials, is mild, skin-friendly, non-irritating, efficient and clean, reduces the occurrence of dry and desquamation phenomena of hand skin, is fine and rich in foam, has whitening and antibacterial effects while preserving moisture and removing old thick cuticles, and is particularly suitable for being used in summer, and the pH value of the hand sanitizer is weak acid and close to that of human skin.
The whitening, antibacterial and exfoliating hand sanitizer disclosed by the invention achieves the functions of efficiently cleaning and removing old thick cuticles mainly through the compounding of the bio-based surfactant, natural vitamins and natural organic acid: one end of the bio-based surfactant molecule is hydrophilic, and the other end is hydrophobic, so that body surface stains such as dust, oil stain, cutin and the like can be emulsified into small microdroplets or stripped and surrounded, and the stains are conveniently removed; the natural vitamins and natural organic acids can mildly soften and remove part of cuticle and promote metabolism of hand skin, so that old thick cuticle and new skin are gradually separated, and the old thick cuticle and the new skin are cooperated with the deep penetration cleaning effect of the bio-based surfactant, so that the aged cuticle can be mostly removed, meanwhile, the delicate new cuticle is not damaged, and an ideal cleaning effect is achieved. Experiments prove that the reasonable compounding effect of the three components is far better than that of the method of removing any one of the three components, which indicates that the three components have a synergistic effect.
The whitening, antibacterial and exfoliating hand sanitizer provided by the invention has the advantages that the addition of the plant extract relaxing factor, the natural organic acid and the bio-based surfactant unexpectedly endows the hand sanitizer with an antibacterial effect, and the effect is closely related to the damage of the natural volatile substances planted with the plant extract relaxing factor, the acidic microenvironment provided by the natural organic acid and the surface damage of the bio-based surfactant to germ cell membranes.
The whitening effect of the whitening, antibacterial and exfoliating hand sanitizer provided by the invention on hands comes from the effects of plant extract relaxing factors, biomass pigment conditioning factors and natural vitamins: the plant extract soothing factor contains components capable of soothing and conditioning the water-oil balance of skin, which provides better conditions for the biomass pigment conditioning factor to exert the conditioning effect on the pigment of hand skin, and the inhibition effect of natural vitamins on melanin fully shows that the three components have the synergistic effect.
The whitening, antibacterial and exfoliating hand sanitizer disclosed by the invention has the following effects that the moisturizing and moistening effects of the hand sanitizer are ensured by the solvent, the plant extract relieving factor, the bio-based surfactant and the biomass pigment conditioning factor: the solvent in reasonable proportion can provide sufficient moisture for skin and simultaneously slow down the evaporation of the moisture; the plant extract soothing factors and the bio-based surfactant can penetrate into the hand skin to retain the moisture of the hand skin, and are beneficial to the permeation and affinity of each effective component to the skin; the glycerol in the biomass pigment conditioning factor has the effect of absorbing moisture in the air. Thus, the moisturizing efficacy of the hand sanitizer is a result of the combined action of these four ingredients.
According to the whitening, antibacterial and exfoliating hand sanitizer, deionized water is added twice during preparation, and natural vitamins are added subsequently, and experiments prove that only through the addition sequence and the proportion, the finally obtained hand sanitizer has an oil-in-water emulsion type, and only through the type, the whitening, antibacterial and exfoliating hand sanitizer can be more stable, various functions can be fully exerted, and otherwise, the effect is greatly reduced.
It should be noted that the above-mentioned embodiments are only for illustrating the technical solutions of the present invention and not for limiting, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions may be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, which should be covered by the claims of the present invention.
Claims (1)
1. A preparation method of a whitening, antibacterial and exfoliating hand sanitizer is characterized by comprising the following steps: comprises the steps of (a) preparing a mixture of a plurality of raw materials,
drying biological aloe containing a pigment conditioning factor, lycium ruthenicum mill, bletilla striata and sea buckthorn in an oven at 32 ℃ for 4 hours in advance according to the mass ratio of 1.2:1.2:1:1.5, fully crushing in a medicine crusher, soaking in 95% ethanol water solution, adding a small amount of baking soda, wherein the mass ratio of the biological aloe containing the pigment conditioning factor, the ethanol water solution and the baking soda is 1.5:22.5:0.15, uniformly mixing the whole system, soaking at-15 ℃ for 24 hours, and filtering to obtain a primary extracting solution; dialyzing and separating the primary extract obtained by filtering at room temperature by using a dialysis membrane with the molecular weight cutoff of 16000 for 5 days, performing rotary evaporation and concentration treatment after dialysis is finished, performing suction filtration by using filter paper with the aperture of 5 mu m, wherein the pump pressure is 0.06MPa, performing freeze drying on the obtained filtrate, performing ultrasonic dispersion on the filtrate in glycerol, and performing freeze drying on the filtrate to obtain solid particles, wherein the mass ratio of the solid particles to the glycerol is 1.5:10, so as to obtain the biomass pigment opsonic factor;
according to the weight parts of the raw materials, 5.5 parts of butanediol, 2.5 parts of tea saponin, 5 parts of soapnut saponin, 3.75 parts of isopropyl myristate, 3.75 parts of alkanolamide and 43 parts of deionized water are stirred and dissolved to be uniform and transparent, then 2.5 parts of origanum vulgaris essential oil, 2 parts of thyme essential oil, 2.5 parts of eucalyptus oil, 6.5 parts of biomass pigment conditioning factor, 1 part of mandelic acid, 0.75 part of gluconic acid and 1.25 parts of ellagic acid are slowly added into the mixture, a high-speed stirrer is used for stirring at 660rpm for 20min at the same time, 43 parts of deionized water, 0.625 part of nicotinamide, 0.625 part of vitamin E and 0.75 part of vitamin C are added, the mixture is continuously stirred at 330rpm for 15min, and a small amount of citric acid or baking soda is used for regulating the pH value to be 6.0, so that a uniform and viscous transparent liquid is the skin-whitening, anti-bacteria and cutin-removing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010725502.6A CN111714399B (en) | 2020-07-24 | 2020-07-24 | Whitening, antibacterial and cutin-removing hand sanitizer and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010725502.6A CN111714399B (en) | 2020-07-24 | 2020-07-24 | Whitening, antibacterial and cutin-removing hand sanitizer and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111714399A CN111714399A (en) | 2020-09-29 |
| CN111714399B true CN111714399B (en) | 2021-04-23 |
Family
ID=72573538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010725502.6A Active CN111714399B (en) | 2020-07-24 | 2020-07-24 | Whitening, antibacterial and cutin-removing hand sanitizer and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN111714399B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114392209A (en) * | 2021-12-29 | 2022-04-26 | 安吉鲁沃夫生物科技有限公司 | Hand sanitizer with long-acting sterilization effect |
| CN115177554B (en) * | 2022-07-15 | 2024-07-23 | 浙江工业大学 | Antibacterial hand sanitizer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103027877A (en) * | 2012-12-14 | 2013-04-10 | 吴江市德佐日用化学品有限公司 | Plant hand sanitizer |
-
2020
- 2020-07-24 CN CN202010725502.6A patent/CN111714399B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103027877A (en) * | 2012-12-14 | 2013-04-10 | 吴江市德佐日用化学品有限公司 | Plant hand sanitizer |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111714399A (en) | 2020-09-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN111920732B (en) | Mite-killing conditioner, shampoo and preparation method thereof | |
| CN111714399B (en) | Whitening, antibacterial and cutin-removing hand sanitizer and preparation method thereof | |
| CN105640834A (en) | Anti-wrinkle oil-removing membrane type skin care products containing theabrownin and preparation method thereof | |
| CN112220726A (en) | Far infrared releasing and moisturizing shower gel and preparation method thereof | |
| CN108354857A (en) | Water beautifying liquid and preparation method thereof is refined after a kind of extraction of witloof polysaccharide | |
| CN111686067B (en) | Anti-dandruff moisturizing shampoo and preparation method thereof | |
| CN115887332A (en) | Skin-firming and anti-wrinkle composition and application thereof | |
| CN109288754A (en) | A kind of Essence and preparation method containing persimmon leaf extractive from fermentative | |
| CN106727255B (en) | Shampoo containing natural surfactant and preparation method thereof | |
| CN112220730A (en) | Preparation method of far infrared releasing biomass skin lotion and product thereof | |
| CN117281762B (en) | High-performance skin care composition and preparation method and application thereof | |
| CN118845576A (en) | A composition for promoting hair growth and repairing hair, and its preparation method and application | |
| CN111759766A (en) | Hand sanitizer capable of releasing far infrared rays and preparation method thereof | |
| CN107375087A (en) | A kind of shower cream and preparation method thereof | |
| CN111281844A (en) | A kind of compound natural extract light spot facial mask and preparation method thereof | |
| JPH01102011A (en) | Skin cosmetic | |
| CN111407711A (en) | Plant essential oil aromatic repairing shampoo and preparation method thereof | |
| CN111759768A (en) | Whitening and cutin removing toner and preparation method thereof | |
| JP5307369B2 (en) | Whitening agent, whitening cosmetic, and method for producing whitening agent | |
| KR102223617B1 (en) | Cosmetic composition containing Clitoria ternatea extract, Buddleja Davidii extract and Centaurea cyanus extract | |
| KR102310366B1 (en) | Skin external composition for anti-aging comprising cyanidin-3-o-glucoside and natto gum | |
| CN115364014A (en) | Multi-effect moisturizing factor and preparation method thereof | |
| CN113797150A (en) | Formula of hyaluronic acid collagen facial mask and preparation method thereof | |
| CN112022784A (en) | Removable fragrant toner and preparation method thereof | |
| KR20230108153A (en) | Natural soap composition for antibacterial cleansing containing skin soothing herbal ingredients |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20210406 Address after: 510000 floor 1 and 2, building 2, No.1, Huaxing Middle Road, Huaxing Industrial Zone, Xinhua Street, Huadu District, Guangzhou City, Guangdong Province Applicant after: GUANGZHOU ZUOFUN COSMETICS Co.,Ltd. Address before: 211111 3203, 2nd floor, Cuiping science and Technology Innovation Park, 37 Jiangjun Avenue, Jiangning District, Nanjing City, Jiangsu Province (Jiangning Development Zone) Applicant before: Nanjing Baihong excellence Technology Co.,Ltd. |
|
| TA01 | Transfer of patent application right | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |