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CN111657927B - Electro-shock device - Google Patents

Electro-shock device Download PDF

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CN111657927B
CN111657927B CN202010699863.8A CN202010699863A CN111657927B CN 111657927 B CN111657927 B CN 111657927B CN 202010699863 A CN202010699863 A CN 202010699863A CN 111657927 B CN111657927 B CN 111657927B
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tremor
fibrillation
electrode
module
impedance
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CN111657927A (en
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刁孟元
朱英
胡炜
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Hangzhou First Peoples Hospital
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00Evaluating a particular growth phase or type of persons or animals
    • A61B2503/40Animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B2503/00Evaluating a particular growth phase or type of persons or animals
    • A61B2503/42Evaluating a particular growth phase or type of persons or animals for laboratory research

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  • Animal Behavior & Ethology (AREA)
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  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Electrotherapy Devices (AREA)

Abstract

The application discloses an electro-fibrillation device, which comprises: acquiring an impedance value between a first defibrillation electrode and a second defibrillation electrode, and acquiring a real-time electrocardiogram through the first defibrillation electrode and the second defibrillation electrode; judging whether the impedance value is larger than a preset impedance threshold value or not, and judging whether a normal electrocardiographic waveform exists in the real-time electrocardiograph or not; when the impedance value is larger than a preset impedance threshold value and/or normal electrocardiographic waveforms do not exist in the real-time electrocardiograph, the positions of the first and second defibrillation electrodes are adjusted; and when the impedance value is smaller than or equal to a preset impedance threshold value and normal electrocardio waveforms exist in the real-time electrocardiogram, controlling the first and second defibrillation electrodes to perform electric defibrillation. The application judges whether the position of the fibrillation inducing electrode is correct or not through the electrocardio and impedance information between the electrodes, provides the most direct judgment basis, and most directly reflects the position of the electrode, and can judge the position of the electrode without a monitor device or a contrast device.

Description

电诱颤装置electrotremor device

技术领域Technical field

本发明属于动物实验领域,具体涉及一种电诱颤装置。The invention belongs to the field of animal experiments, and specifically relates to an electric tremor-inducing device.

背景技术Background technique

在医学临床的动物实验过程中,经常需要使得实验动物对象产生非正常心律,以模拟患病的心律条件,来验证医疗器械或者药物的安全性、有效性。其中最常见的是使得实验动物产生室颤心律;例如,在对除颤仪、AED等除颤设备进行动物实验时,必须要使动物产生可除颤心律(通常是室颤心律),除颤仪、AED等除颤设备才有了实验治疗对象,才能触发设备进行除颤操作。因此,在这类动物实验中,对实验动物进行诱颤,即诱发室颤,是进行动物实验准备的关键操作。In the process of animal experiments in clinical medicine, it is often necessary to cause experimental animal subjects to produce abnormal heart rhythms to simulate diseased heart rhythm conditions and verify the safety and effectiveness of medical devices or drugs. The most common one is to cause experimental animals to produce ventricular fibrillation rhythm; for example, when conducting animal experiments on defibrillation equipment such as defibrillators and AEDs, it is necessary to make the animals produce a defibrillable heart rhythm (usually a ventricular fibrillation rhythm). Defibrillators, AEDs and other defibrillation equipment only have experimental treatment subjects and can trigger the equipment to perform defibrillation operations. Therefore, in this type of animal experiment, inducing fibrillation in experimental animals, that is, inducing ventricular fibrillation, is a key operation in preparing for animal experiments.

诱颤有多种方法,例如,药物诱颤,窒息诱颤,电诱颤。其中药物诱颤和窒息诱颤会对动物的心肌等组织造成损伤,形成了动物实验过程的干扰因素;例如,在除颤设备的动物实验流程中,需要对除颤治疗结束的动物心肌进行切片检验,其检验结果会作为分析除颤设备安全性的重要因素,而药物诱颤和窒息诱颤对心肌组织的影响会干扰这一项分析。There are many ways to induce tremor, such as drug-induced tremor, asphyxiation-induced tremor, and electrical tremor-induced tremor. Among them, drug-induced tremor and asphyxiation-induced tremor can cause damage to the myocardium and other tissues of animals, forming interference factors in the animal experiment process; for example, in the animal experiment process of defibrillation equipment, it is necessary to slice the myocardium of animals after defibrillation treatment. The test results will be used as an important factor in analyzing the safety of defibrillation equipment, and the effects of drug-induced fibrillation and asphyxia-induced fibrillation on myocardial tissue will interfere with this analysis.

电诱颤是一种优秀的诱发动物发生室颤的方法,其对动物的影响干扰程度较小。但是,当前实验室用的电诱颤方法通常比较粗放,没有进行精确的控制,而且诱颤容易失败,需要反复尝试多次才能诱颤成功,这取决于与实验操作人员的熟练程度。Electrical fibrillation is an excellent method to induce ventricular fibrillation in animals, and its impact on animals is relatively small. However, the current electrotremor induction methods used in laboratories are usually extensive and lack precise control, and the induction of tremor is prone to failure. It requires repeated attempts to successfully induce tremor, which depends on the proficiency of the experimental operator.

因此,针对上述技术问题,有必要提供一种电诱颤装置。Therefore, in order to solve the above technical problems, it is necessary to provide an electric tremor-inducing device.

发明内容Contents of the invention

有鉴于此,本发明的目的在于提供一种电诱颤装置,以实现对电诱颤的精准控制。In view of this, the object of the present invention is to provide an electric tremor-inducing device to achieve precise control of electric tremor-inducing.

为了实现上述目的,本发明一实施例提供的技术方案如下:In order to achieve the above object, the technical solution provided by an embodiment of the present invention is as follows:

一种电诱颤方法,包括以下步骤:An electric tremor inducing method includes the following steps:

获取第一诱颤电极和第二诱颤电极之间的阻抗值,通过第一诱颤电极和第二诱颤电极获取实时心电图;Obtain the impedance value between the first fibrillation-inducing electrode and the second fibrillation-inducing electrode, and obtain a real-time electrocardiogram through the first fibrillation-inducing electrode and the second fibrillation-inducing electrode;

判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;Determine whether the impedance value is greater than the preset impedance threshold, and determine whether there is a normal ECG waveform in the real-time ECG;

当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;When the impedance value is greater than the preset impedance threshold and/or there is no normal electrocardiogram waveform in the real-time electrocardiogram, adjust the positions of the first fibrillation inducing electrode and the second fibrillation inducing electrode;

当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。When the impedance value is less than or equal to the preset impedance threshold and a normal electrocardiogram waveform exists in the real-time electrocardiogram, the first fibrillation inducing electrode and the second fibrillation inducing electrode are controlled to perform electrical fibrillation induction.

一实施例中,“控制第一诱颤电极和第二诱颤电极进行电诱颤”在恒压或恒流模式下进行。In one embodiment, "controlling the first fibrillation inducing electrode and the second fibrillation inducing electrode to perform electrical tremor inducing" is performed in a constant voltage or constant current mode.

一实施例中,“控制第一诱颤电极和第二诱颤电极进行电诱颤”具体为:In one embodiment, "controlling the first tremor-inducing electrode and the second tremor-inducing electrode to perform electrical tremor induction" is specifically:

在自动模式下,当阻抗值小于或等于预设阻抗阈值且实时心电图中不存在正常心电波形时,等待时间t1,自动开始电诱颤,维持电诱颤时间t11后,停止电诱颤,监测实时心电图中是否存在室颤心率波形,如否,则继续电诱颤,如是,则电诱颤成功,记录数据参数;In the automatic mode, when the impedance value is less than or equal to the preset impedance threshold and there is no normal ECG waveform in the real-time ECG, the electric tremor induction will automatically start after waiting time t1. After maintaining the electric tremor induction time t11, the electric fibrillation induction will stop. Monitor whether there is ventricular fibrillation heart rate waveform in the real-time electrocardiogram. If not, continue the electrical fibrillation induction. If so, the electrical fibrillation induction is successful and record the data parameters;

在半自动模式下,当阻抗值小于或等于预设阻抗阈值且实时心电图中不存在正常心电波形时,等待时间t2,手动开始电诱颤,维持电诱颤时间t21后,监测实时心电图中是否存在室颤心率波形,如否,则继续电诱颤,如是,则电诱颤成功,记录数据参数。In the semi-automatic mode, when the impedance value is less than or equal to the preset impedance threshold and there is no normal ECG waveform in the real-time ECG, wait for the time t2 and manually start the electric fibrillation induction. After maintaining the electric fibrillation induction time t21, monitor whether the real-time ECG is There is a ventricular fibrillation heart rate waveform. If not, continue the electrical fibrillation induction. If so, the electrical fibrillation induction is successful and record the data parameters.

本发明另一实施例提供的技术方案如下:The technical solution provided by another embodiment of the present invention is as follows:

一种电诱颤装置包括:An electrotremor-inducing device includes:

第一诱颤电极和第二诱颤电极,用于进行电诱颤;The first tremor-inducing electrode and the second tremor-inducing electrode are used for electrical tremor induction;

阻抗检测模块,与第一诱颤电极和第二诱颤电极电性连接,用于获取第一诱颤电极和第二诱颤电极之间的阻抗值;an impedance detection module, electrically connected to the first tremor-inducing electrode and the second tremor-inducing electrode, and used to obtain the impedance value between the first tremor-inducing electrode and the second tremor-inducing electrode;

心电监测模块,与第一诱颤电极和第二诱颤电极电性连接,用于通过第一诱颤电极和第二诱颤电极获取实时心电图;An electrocardiogram monitoring module, electrically connected to the first fibrillation-inducing electrode and the second fibrillation-inducing electrode, and used to obtain real-time electrocardiogram through the first fibrillation-inducing electrode and the second fibrillation-inducing electrode;

处理器,分别与阻抗检测模块和心电监测模块电性连接,用于判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。The processor is electrically connected to the impedance detection module and the ECG monitoring module respectively, and is used to determine whether the impedance value is greater than the preset impedance threshold, and to determine whether there is a normal ECG waveform in the real-time ECG; when the impedance value is greater than the preset impedance threshold and /or When there is no normal ECG waveform in the real-time ECG, adjust the positions of the first tremor-inducing electrode and the second fibrillation-inducing electrode; when the impedance value is less than or equal to the preset impedance threshold and there is a normal ECG waveform in the real-time ECG , controls the first tremor-inducing electrode and the second tremor-inducing electrode to perform electrical tremor induction.

另一实施例中,所述第一诱颤电极和第二诱颤电极分别通过第一开关与阻抗检测模块和心电监测模块电性连接,所述处理器还用于控制第一开关的开启或关闭。In another embodiment, the first fibrillation-inducing electrode and the second fibrillation-inducing electrode are electrically connected to the impedance detection module and the ECG monitoring module through a first switch respectively, and the processor is also used to control the opening of the first switch. or close.

另一实施例中,所述电诱颤装置还包括与处理器电性连接的电源处理模块以及与电源处理模块电性连接的电源,所述电源处理模块同时与第一诱颤电极和第二诱颤电极电性连接。In another embodiment, the electrotremor inducing device further includes a power processing module electrically connected to the processor and a power supply electrically connected to the power processing module. The power processing module is simultaneously connected to the first tremor inducing electrode and the second fibrillation inducing electrode. The tremor-inducing electrodes are electrically connected.

另一实施例中,所述电源处理模块与第一诱颤电极、第二诱颤电极之间电性连接有控制输出模块,所述控制输出模块同时与处理器电性连接。In another embodiment, a control output module is electrically connected between the power processing module and the first tremor-inducing electrode and the second tremor-inducing electrode, and the control output module is electrically connected to the processor at the same time.

另一实施例中,所述第一诱颤电极和第二诱颤电极分别通过第二开关与控制输出模块电性连接,所述处理器还用于控制第二开关的开启或关闭。In another embodiment, the first tremor-inducing electrode and the second tremor-inducing electrode are electrically connected to the control output module through a second switch respectively, and the processor is also used to control the opening or closing of the second switch.

另一实施例中,所述电诱颤装置还包括与处理器电性连接的显示界面模块、语音提示模块、存储记录模块和按键操作模块。In another embodiment, the electrotremor inducing device further includes a display interface module, a voice prompt module, a storage and recording module and a key operation module that are electrically connected to the processor.

与现有技术相比,本发明具有以下优点:Compared with the prior art, the present invention has the following advantages:

本发明通过诱颤电极间的心电、阻抗信息判断诱颤电极位置是否正确,提供了最直接的判断依据,最直接的反映了诱颤电极的位置,即与心室内壁接触就有正常心电且阻抗小,否则就没有接触,简单有效,且无需更多其它监护仪设备或者造影设备即可判断电极位置。The present invention determines whether the position of the fibrillation-inducing electrode is correct through the ECG and impedance information between the fibrillation-inducing electrodes, provides the most direct basis for judgment, and most directly reflects the position of the fibrillation-inducing electrode, that is, there is a normal ECG when in contact with the inner wall of the ventricle. And the impedance is small, otherwise there will be no contact, it is simple and effective, and no more other monitor equipment or imaging equipment is needed to determine the electrode position.

附图说明Description of the drawings

为了更清楚地说明本申请实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本申请中记载的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to explain the embodiments of the present application or the technical solutions in the prior art more clearly, the drawings needed to be used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings in the following description are only These are some embodiments recorded in this application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without exerting creative efforts.

图1为本发明一实施例中电诱颤的流程图;Figure 1 is a flow chart of electrotremor induction in one embodiment of the present invention;

图2为本发明一实施例中电诱颤装置的电路结构示意图;Figure 2 is a schematic diagram of the circuit structure of the electric tremor induction device in one embodiment of the present invention;

图3为本发明一实施例中控制输出模块输出的电压波形图;Figure 3 is a voltage waveform diagram output by the control output module in an embodiment of the present invention;

图4为本发明一实施例中控制输出模块输出的电流波形图。Figure 4 is a current waveform diagram output by the control output module in an embodiment of the present invention.

具体实施方式Detailed ways

以下将结合附图所示的各实施方式对本发明进行详细描述。但该等实施方式并不限制本发明,本领域的普通技术人员根据该等实施方式所做出的结构、方法、或功能上的变换均包含在本发明的保护范围内。The present invention will be described in detail below with reference to each embodiment shown in the drawings. However, these embodiments do not limit the present invention. Structural, method, or functional changes made by those of ordinary skill in the art based on these embodiments are all included in the protection scope of the present invention.

本发明公开了一种电诱颤方法,包括以下步骤:The invention discloses an electric tremor-inducing method, which includes the following steps:

获取第一诱颤电极和第二诱颤电极之间的阻抗值,通过第一诱颤电极和第二诱颤电极获取实时心电图;Obtain the impedance value between the first fibrillation-inducing electrode and the second fibrillation-inducing electrode, and obtain a real-time electrocardiogram through the first fibrillation-inducing electrode and the second fibrillation-inducing electrode;

判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;Determine whether the impedance value is greater than the preset impedance threshold, and determine whether there is a normal ECG waveform in the real-time ECG;

当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;When the impedance value is greater than the preset impedance threshold and/or there is no normal electrocardiogram waveform in the real-time electrocardiogram, adjust the positions of the first fibrillation inducing electrode and the second fibrillation inducing electrode;

当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。When the impedance value is less than or equal to the preset impedance threshold and a normal electrocardiogram waveform exists in the real-time electrocardiogram, the first fibrillation inducing electrode and the second fibrillation inducing electrode are controlled to perform electrical fibrillation induction.

以下结合具体实施例对本发明作进一步说明。The present invention will be further described below in conjunction with specific examples.

参图1所示,本发明公开了一种电诱颤方法,包括以下步骤:Referring to Figure 1, the present invention discloses an electric tremor induction method, which includes the following steps:

获取第一诱颤电极和第二诱颤电极之间的阻抗值,通过第一诱颤电极和第二诱颤电极获取实时心电图;Obtain the impedance value between the first fibrillation-inducing electrode and the second fibrillation-inducing electrode, and obtain a real-time electrocardiogram through the first fibrillation-inducing electrode and the second fibrillation-inducing electrode;

判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;Determine whether the impedance value is greater than the preset impedance threshold, and determine whether there is a normal ECG waveform in the real-time ECG;

当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;When the impedance value is greater than the preset impedance threshold and/or there is no normal electrocardiogram waveform in the real-time electrocardiogram, adjust the positions of the first fibrillation inducing electrode and the second fibrillation inducing electrode;

当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。When the impedance value is less than or equal to the preset impedance threshold and a normal electrocardiogram waveform exists in the real-time electrocardiogram, the first fibrillation inducing electrode and the second fibrillation inducing electrode are controlled to perform electrical fibrillation induction.

其中,预设阻抗阈值为10kΩ。Among them, the preset impedance threshold is 10kΩ.

本实施例中,控制第一诱颤电极和第二诱颤电极在恒压或者恒流模式下进行电诱颤。In this embodiment, the first tremor inducing electrode and the second tremor inducing electrode are controlled to perform electrotremor inducing in a constant voltage or constant current mode.

本实施例中,在自动模式下,当阻抗值小于或等于10kΩ且实时心电图中存在正常心电波形时,等待时间t1,自动开始电诱颤,维持电诱颤时间t11后,停止电诱颤,监测实时心电图中是否存在室颤心率波形,如否,则继续电诱颤,如是,则电诱颤成功,记录数据参数;In this embodiment, in the automatic mode, when the impedance value is less than or equal to 10kΩ and there is a normal electrocardiogram waveform in the real-time electrocardiogram, the electrofibrillation induction is automatically started after waiting time t1, and the electrofibrillation induction is stopped after maintaining the electrofibrillation induction time t11. , monitor whether there is ventricular fibrillation heart rate waveform in the real-time electrocardiogram, if not, continue the electric fibrillation induction, if so, the electric fibrillation induction is successful, and record the data parameters;

在半自动模式下,当阻抗值小于或等于10kΩ且实时心电图中存在正常心电波形时,等待时间t2,手动开始电诱颤,维持电诱颤时间t21后,监测实时心电图中是否存在室颤心率波形,如否,则继续电诱颤,如是,则电诱颤成功,记录数据参数。In the semi-automatic mode, when the impedance value is less than or equal to 10kΩ and there is a normal ECG waveform in the real-time ECG, wait for time t2, manually start electric fibrillation induction, and after maintaining the electric fibrillation induction time t21, monitor whether there is ventricular fibrillation heart rate in the real-time ECG waveform, if no, continue to induce tremor, if yes, the electric tremor induction is successful, and record the data parameters.

数据参数记录内容包括:1.全过程监测到的心电波形,2.第一诱颤电极和第二诱颤电极之间的阻抗值,3.诱颤模式:恒压模式/恒流模式,自动模式/半自动模式,4.诱颤次数,5.每一次诱颤的诱颤电压值(恒压模式下即为V值,恒流模式下为I与阻抗值的乘积)和电流值(恒压模式下为V与阻抗值之间的比值,恒流模式下即为I值)。6.心率即恒压/恒流的诱颤方波频率值。The data parameter recording content includes: 1. The ECG waveform monitored during the whole process, 2. The impedance value between the first fibrillation inducing electrode and the second fibrillation inducing electrode, 3. Tremor inducing mode: constant voltage mode/constant current mode, Automatic mode/semi-automatic mode, 4. The number of tremor inductions, 5. The tremor voltage value of each tremor induction (in constant voltage mode, it is the V value, in the constant current mode, it is the product of I and the impedance value) and current value (constant In voltage mode, it is the ratio between V and the impedance value, and in constant current mode, it is the I value). 6. The heart rate is the tremor-inducing square wave frequency value of constant voltage/constant current.

参图2所示,本发明还公开了一种电诱颤装置,包括:用于进行电诱颤的第一诱颤电极A和第二诱颤电极B、用于获取第一诱颤电极A和第二诱颤电极B之间的阻抗值的阻抗检测模块、用于通过第一诱颤电极A和第二诱颤电极B获取实时心电图的心电监测模块以及处理器CPU。Referring to Figure 2, the present invention also discloses an electric tremor inducing device, which includes: a first tremor inducing electrode A and a second tremor inducing electrode B for performing electric tremor inducing; an impedance detection module for the impedance value between the first fibrillation electrode A and the second fibrillation electrode B, an electrocardiogram monitoring module for obtaining real-time electrocardiogram through the first fibrillation electrode A and the second fibrillation electrode B, and a processor CPU.

具体的,其中一个诱颤电极放置在动物皮肤表面离心脏较近的位置、另一个诱颤电极通过有创插管被放置到与动物心室内壁接触,阻抗检测模块与第一诱颤电极A和第二诱颤电极B电性连接,心电监测模块与第一诱颤电极A和第二诱颤电极B电性连接,第一诱颤电极A和第二诱颤电极B分别通过第一开关K1与阻抗检测模块和心电监测模块电性连接。Specifically, one of the tremor-inducing electrodes is placed on the surface of the animal's skin closer to the heart, the other fibrillation-inducing electrode is placed in contact with the inner wall of the animal's ventricle through an invasive cannula, and the impedance detection module is connected to the first fibrillation-inducing electrode A and The second fibrillation electrode B is electrically connected, and the ECG monitoring module is electrically connected to the first fibrillation electrode A and the second fibrillation electrode B. The first fibrillation electrode A and the second fibrillation electrode B pass through the first switch respectively. K1 is electrically connected to the impedance detection module and the ECG monitoring module.

参图2所示,处理器CPU分别与阻抗检测模块和心电监测模块电性连接,处理器CPU用于判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极A和第二诱颤电极B的位置进行调整;当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极A和第二诱颤电极B进行电诱颤,处理器CPU还用于控制第一开关K1的开启或关闭,从而控制阻抗检测模块和心电监测模块与第一诱颤电极A、第一诱颤电极B之间的断开和连接。As shown in Figure 2, the processor CPU is electrically connected to the impedance detection module and the ECG monitoring module respectively. The processor CPU is used to determine whether the impedance value is greater than the preset impedance threshold and determine whether there is a normal ECG waveform in the real-time ECG; When the impedance value is greater than the preset impedance threshold and/or there is no normal ECG waveform in the real-time electrocardiogram, adjust the positions of the first fibrillation electrode A and the second fibrillation electrode B; when the impedance value is less than or equal to the preset impedance threshold and there is a normal electrocardiogram waveform in the real-time electrocardiogram, the first tremor-inducing electrode A and the second tremor-inducing electrode B are controlled to induce tremor. The processor CPU is also used to control the opening or closing of the first switch K1 to control the impedance. Disconnection and connection between the detection module and the ECG monitoring module and the first fibrillation electrode A and the first fibrillation electrode B.

参图2所示,电诱颤装置还包括与处理器CPU电性连接的电源处理模块以及与电源处理模块电性连接的电源,电源为市电(交流电220V),电源处理模块同时与第一诱颤电极A和第二诱颤电极B电性连接,电源处理模块与第一诱颤电极A、第二诱颤电极B之间电性连接有控制输出模块,控制输出模块同时与处理器CPU电性连接,第一诱颤电极A和第二诱颤电极B分别通过第二开关K2与控制输出模块电性连接,处理器CPU还用于控制第二开关K2的开启或关闭,从而控制控制输出模块与第一诱颤电极A和第一诱颤电极B之间的断开和连接。As shown in Figure 2, the electric tremor induction device also includes a power processing module electrically connected to the processor CPU and a power supply electrically connected to the power processing module. The power supply is commercial power (AC 220V), and the power processing module is connected to the first power supply at the same time. The tremor-inducing electrode A and the second tremor-inducing electrode B are electrically connected, and a control output module is electrically connected between the power processing module and the first tremor-inducing electrode A and the second tremor-inducing electrode B. The control output module is also connected to the processor CPU. Electrically connected, the first tremor-inducing electrode A and the second tremor-inducing electrode B are electrically connected to the control output module through the second switch K2. The processor CPU is also used to control the opening or closing of the second switch K2, thereby controlling the control Disconnection and connection between the output module and the first tremor-inducing electrode A and the first tremor-inducing electrode B.

本实施例中,处理器CPU采用的芯片为STM32F103VGT6,心电监测模块采用的芯片为ADS1198,阻抗检测模块采用的芯片为AD5934。In this embodiment, the chip used in the processor CPU is STM32F103VGT6, the chip used in the ECG monitoring module is ADS1198, and the chip used in the impedance detection module is AD5934.

参图2所示,电诱颤装置还包括与处理器CPU电性连接的显示界面模块、语音提示模块、存储记录模块和按键操作模块,显示模块采用的芯片为SSD1963QL9,语音提示模块采用的芯片为KT1025A。As shown in Figure 2, the electrotremor induction device also includes a display interface module, a voice prompt module, a storage recording module and a key operation module that are electrically connected to the processor CPU. The chip used in the display module is SSD1963QL9, and the chip used in the voice prompt module for KT1025A.

其中,电源处理模块用于对电源进行降压、整流等处理后,为处理器CPU、显示界面模块、语音提示模块、存储记录模块和按键操作模块等供电,同时也为控制输出模块提供诱颤电源。Among them, the power processing module is used to step down and rectify the power supply, and then supply power to the processor CPU, display interface module, voice prompt module, storage recording module and key operation module. It also provides tremor induction for the control output module. power supply.

本实施例中,控制输出模块用于将电源处理模块提供的诱颤电源调整成所需的对应的诱颤电压或诱颤电流并直接输出到第一诱颤电极A和第一诱颤电极B。In this embodiment, the control output module is used to adjust the tremor-inducing power provided by the power processing module to the required corresponding trembling-inducing voltage or current and directly output it to the first trembling-inducing electrode A and the first trembling-inducing electrode B. .

本实施例中,按键操作模块包括恒压模式按钮、恒流模式按钮、自动模式按钮、半自动模式按钮、启动诱颤按钮、电压调节旋钮以及电流调节旋钮,用于控制处理器CPU进入恒压模式/恒流模式、自动模式/半自动模式以及启动诱颤,并对电压和电流进行调节。In this embodiment, the key operation module includes a constant voltage mode button, a constant current mode button, an automatic mode button, a semi-automatic mode button, a start-up tremor button, a voltage adjustment knob and a current adjustment knob, which are used to control the processor CPU to enter the constant voltage mode. /Constant current mode, automatic mode/semi-automatic mode and start tremor, and adjust voltage and current.

半自动模式和自动模式,可以根据不同的熟练程度进行选择,提供了操作效率;且两种模式下,均可根据诱颤结果的提示进行操作,非常方便。Semi-automatic mode and automatic mode can be selected according to different proficiency levels, which improves operating efficiency; and in both modes, operations can be performed according to the prompts of the tremor induction results, which is very convenient.

参图3所示,在恒压模式下,在处理器CPU的控制下控制输出模块将电源处理模块的输出转化为恒压输出的双向方波(50:50),在诱颤过程中,其方波幅值为恒定V(恒定即:无论阻抗检测的值为多少或者如何变化,且在诱颤过程中无论控制输出的负载有任何的扰动和变化,其输出的电压幅值恒定为V,而电流随负载或阻抗进行调节变化),V值可通过电压调节旋钮预先进行设定,其中V值调节范围优选为1V至12V,方波的周期为T(频率f=1/T),方波频率优选的值为心电监测模块所获取的心电心率值,方波频率与心率值相等,恒压模式下,恒流模式按钮、电流调节旋钮不工作。As shown in Figure 3, in constant voltage mode, the output module is controlled under the control of the processor CPU to convert the output of the power processing module into a bidirectional square wave (50:50) of constant voltage output. During the tremor induction process, The amplitude of the square wave is constant V (constant means: no matter what the value of the impedance detection is or how it changes, and no matter there is any disturbance or change in the load controlling the output during the tremor induction process, the output voltage amplitude is constant V, The current adjusts with the load or impedance), and the V value can be preset through the voltage adjustment knob. The V value adjustment range is preferably 1V to 12V. The period of the square wave is T (frequency f = 1/T). The preferred value of the wave frequency is the ECG heart rate value obtained by the ECG monitoring module. The square wave frequency is equal to the heart rate value. In constant voltage mode, the constant current mode button and current adjustment knob do not work.

参图4所示,在恒流模式下,在处理器CPU的控制下控制输出模块将电源处理模块的输出转化为恒流输出的双向方波(50:50),在诱颤过程中,其电流方波幅值为恒定I(恒定即:无论阻抗检测的值为多少或者如何变化,且在诱颤过程中无论控制输出的负载有任何的扰动和变化,其输出的电流幅值恒定为I,而电压随负载或阻抗进行调节变化),I值可通过电流调节旋钮预先进行设定,其中I值调节范围优选为1mA至20mA,方波的周期为T(频率f=1/T),方波频率优选的值为心电监测模块所获取的心电心率值,方波频率与心率值相等,恒流模式下,恒压模式按钮、电压调节旋钮不工作。As shown in Figure 4, in the constant current mode, under the control of the processor CPU, the output module is controlled to convert the output of the power processing module into a bidirectional square wave (50:50) of constant current output. During the tremor induction process, The amplitude of the current square wave is constant I (constant, that is: no matter what the value of the impedance detection is or how it changes, and no matter there are any disturbances and changes in the load controlling the output during the tremor induction process, the output current amplitude is constant I , and the voltage changes with the load or impedance), the I value can be preset through the current adjustment knob, where the I value adjustment range is preferably 1mA to 20mA, and the period of the square wave is T (frequency f=1/T). The preferred value of the square wave frequency is the ECG heart rate value obtained by the ECG monitoring module. The square wave frequency is equal to the heart rate value. In constant current mode, the constant voltage mode button and voltage adjustment knob do not work.

恒压模式和恒流模式下精确的输出波形,诱颤参数稳定、确定,在多个动物实验的对比中,不会形成干扰因素。Accurate output waveforms in constant voltage mode and constant current mode, the tremor-inducing parameters are stable and certain, and there will be no interference factors in the comparison of multiple animal experiments.

本实施例中,存储记录模块用于存储电诱颤过程中的参数,包括:诱颤电流曲线、诱颤电压曲线、阻抗记录、诱颤持续时间记录、诱颤结果、诱颤次数,多项诱颤参数的记录,便于多个动物实验对比时,作为数据分析、分组的依据,提供了更多的实验分析所需的数据。In this embodiment, the storage and recording module is used to store parameters during the electrical tremor induction process, including: tremor induction current curve, tremor induction voltage curve, impedance record, tremor induction duration record, tremor induction results, tremor induction times, and multiple items. The recording of tremor-inducing parameters facilitates comparison of multiple animal experiments and serves as the basis for data analysis and grouping, providing more data required for experimental analysis.

本实施例中,语言提示装置用于语音提示按键操作模块的设置模式,在诱颤过程中提示操作步骤和操作动作。In this embodiment, the language prompt device is used to voice prompt the setting mode of the key operation module, and prompts the operating steps and actions during the tremor induction process.

本实施例中,显示界面模块用于显示按键操作模块的设置模式,实时显示经第一诱颤电极A和第一诱颤电极B采集的心电图、显示诱颤持续的时间、显示已经进行的诱颤次数和当前的诱颤结果。In this embodiment, the display interface module is used to display the setting mode of the key operation module, display the electrocardiogram collected by the first tremor-inducing electrode A and the first tremor-inducing electrode B in real time, display the duration of the tremor-induced tremor, and display the inducing tremor that has been carried out. number of tremors and current tremor induction results.

通过语音和界面显示不断的提示和指导诱颤操作,增加了使用的便利性。Continuous prompts and guidance for tremor-inducing operations are provided through voice and interface display, which increases the convenience of use.

参图1并结合图2所示,当第一诱颤电极A和B准备待用后,闭合第一开关K1维持第二开关K2为断开,心电监测模块获取实时心电图、阻抗检测模块获取第一诱颤电极A和第一诱颤电极B之间的阻抗值;处理器CPU识别心电图信息和阻抗值,当识别到心电图属于非正常心电波形或者阻抗值大于10K这两个设定的条件之一时,说明第一诱颤电极A和第一诱颤电极B之间没有心电图信息,即表明心内置管的诱颤电极未与心室内壁接触,此时发出语音提示置管诱颤电极位置不对,需要重新调整其位置;经过反复判断和调整,直至上述的两个设定的条件均没有发生,说明心内置管的诱颤电极与心室内壁接触良好,此时语音提示诱颤电极位置良好需要固定电极位置,并同时界面显示通过第一诱颤电极A和第一诱颤电极B获取的心电图以及具体的阻抗值。Referring to Figure 1 and combined with Figure 2, when the first fibrillation-inducing electrodes A and B are ready for use, close the first switch K1 and keep the second switch K2 open. The ECG monitoring module obtains the real-time ECG and the impedance detection module obtains The impedance value between the first tremor-inducing electrode A and the first fibrillation-inducing electrode B; the processor CPU recognizes the electrocardiogram information and the impedance value. When it recognizes that the electrocardiogram belongs to an abnormal electrocardiogram waveform or the impedance value is greater than 10K, the two settings When one of the conditions is met, it means that there is no electrocardiogram information between the first fibrillation-inducing electrode A and the first fibrillation-inducing electrode B, which means that the fibrillation-inducing electrode of the intracardiac tube is not in contact with the inner wall of the ventricle. At this time, a voice prompt is issued to indicate the position of the fibrillation-inducing electrode inserted in the heart. Wrong, the position needs to be readjusted; after repeated judgment and adjustment, until the above two set conditions have not occurred, it means that the fibrillation-inducing electrode of the intracardiac tube is in good contact with the inner wall of the ventricle. At this time, the voice prompts that the fibrillation-inducing electrode is in a good position. The electrode positions need to be fixed, and at the same time, the interface displays the electrocardiogram acquired through the first tremor-inducing electrode A and the first fibrillation-inducing electrode B and the specific impedance value.

完成上述第一诱颤电极A和第一诱颤电极B的位置放置后,如果选择为半自动模式下,则等待时间t2,时间t2优选值为5秒,等待时间t2结束后,语音提示和界面显示:可诱颤并请按下启动诱颤按钮;当检测到启动诱颤按钮被按下后,则断开第一开关K1并闭合第二开关K2,维持诱颤输出,经过时间t21,优选的时间t21为3秒,时间t21结束后,闭合第一开关K1并断开第二开关K2,然后处理器CPU立即监测识别心电波形是否为室颤心律波形,如果不是室颤心律波形,即重复等待时间t2及后续的过程;直至处理器CPU识别到室颤心律波形,此时界面显示室颤心律波形并语音提示诱颤成功,并记录上述过程中的诱颤参数值。After completing the positioning of the first tremor-inducing electrode A and the first tremor-inducing electrode B, if the semi-automatic mode is selected, the waiting time t2 is selected. The preferred value of time t2 is 5 seconds. After the waiting time t2 is completed, the voice prompts and interface Display: tremor can be induced and please press the tremor start button; when it is detected that the tremor start button is pressed, the first switch K1 is turned off and the second switch K2 is closed to maintain the tremor output after time t21, preferably The time t21 is 3 seconds. After the time t21 is over, the first switch K1 is closed and the second switch K2 is opened. Then the processor CPU immediately monitors and identifies whether the ECG waveform is a ventricular fibrillation rhythm waveform. If it is not a ventricular fibrillation rhythm waveform, that is Repeat the waiting time t2 and subsequent processes until the processor CPU recognizes the ventricular fibrillation rhythm waveform. At this time, the interface displays the ventricular fibrillation rhythm waveform and a voice prompts that the fibrillation induction is successful, and records the fibrillation induction parameter values in the above process.

完成上述诱颤电极的位置放置后,如果选择为自动模式下,则等待一段时间t1,时间t1优选值为15秒,等待时间t1结束后,语音提示和界面显示:可诱颤并于等待10后开始诱颤请勿干扰;当等待10秒倒计时结束后,自动断开第一开关K1并闭合第二开关K2,并维持诱颤输出,经过时间t11,优选的时间t11时间为3秒,时间t11结束后,闭合第一开关K1并断开第二开关K2,然后处理器CPU立即监测识别心电波形是否为室颤心律波形,如果不是室颤心律波形,即重复等待时间t1及后续的过程;直至处理器CPU识别到室颤心律波形,此时界面显示室颤心律波形并语音提示诱颤成功,并记录上述过程中的诱颤参数值。After completing the placement of the above tremor-inducing electrodes, if the automatic mode is selected, wait for a period of time t1. The preferred value of time t1 is 15 seconds. After the waiting time t1 is over, the voice prompt and interface display: Tremor can be induced and wait for 10 seconds. Please do not interfere after starting the tremor induction; when the 10-second countdown is over, the first switch K1 is automatically turned off and the second switch K2 is closed, and the tremor induction output is maintained. After the time t11, the preferred time t11 is 3 seconds. After t11 ends, close the first switch K1 and open the second switch K2. Then the processor CPU immediately monitors and identifies whether the ECG waveform is a ventricular fibrillation rhythm waveform. If it is not a ventricular fibrillation rhythm waveform, the waiting time t1 and subsequent processes are repeated. ; Until the processor CPU recognizes the ventricular fibrillation rhythm waveform, at this time the interface displays the ventricular fibrillation rhythm waveform and a voice prompts that the fibrillation induction is successful, and records the fibrillation induction parameter values in the above process.

参数记录内容包括:1.全过程的心电监测模块监测到的心电波形;2.诱颤电极间的阻抗值;3.诱颤模式:恒压模式/恒流模式,自动模式/半自动模式;4.诱颤次数;5.每一次诱颤的诱颤电压值(恒压模式下即为V值,恒流模式下为I与阻抗值的乘积)和电流值(恒压模式下为V与阻抗值之间的比值,恒流模式下即为I值);6.心率即恒压/恒流的诱颤方波频率值。Parameter recording content includes: 1. The ECG waveform monitored by the ECG monitoring module throughout the entire process; 2. The impedance value between the fibrillation-inducing electrodes; 3. The fibrillation-inducing mode: constant voltage mode/constant current mode, automatic mode/semi-automatic mode ; 4. The number of tremor inductions; 5. The tremor voltage value of each tremor induction (in constant voltage mode, it is the V value, in the constant current mode, it is the product of I and the impedance value) and the current value (in the constant voltage mode, it is V The ratio to the impedance value is the I value in constant current mode); 6. The heart rate is the tremor-inducing square wave frequency value of constant voltage/constant current.

本实施例中,自动模式和半自动模式下,均可以输出恒流模式下或者恒压模式下设定的诱颤输出的双向方波。In this embodiment, in both the automatic mode and the semi-automatic mode, the bidirectional square wave of the tremor-inducing output set in the constant current mode or the constant voltage mode can be output.

由以上技术方案可以看出,本发明具有以下有益效果:It can be seen from the above technical solutions that the present invention has the following beneficial effects:

本发明通过第一诱颤电极和第二诱颤电极之间的心电波形、阻抗信息判断电极的位置是否正确,提供了最直接的判断依据,最直接的反映了电极的位置,即与心室内壁接触就有正常心电且阻抗小,否则就没有接触,简单有效;且无需更多其它监护仪设备或者造影设备即可判断电极位置。The present invention determines whether the position of the electrode is correct through the ECG waveform and impedance information between the first fibrillation-inducing electrode and the second fibrillation-inducing electrode, provides the most direct basis for judgment, and most directly reflects the position of the electrode, that is, relative to the ventricle. If the inner wall is in contact, there will be normal ECG and low impedance. Otherwise, there will be no contact. It is simple and effective; and no more other monitor equipment or imaging equipment is needed to determine the electrode position.

对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。It is obvious to those skilled in the art that the present invention is not limited to the details of the above-described exemplary embodiments, and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, the embodiments should be regarded as illustrative and non-restrictive from any point of view, and the scope of the present invention is defined by the appended claims rather than the above description, and it is therefore intended that all claims falling within the claims All changes within the meaning and scope of equivalent elements are included in the present invention. Any reference signs in the claims shall not be construed as limiting the claim in question.

此外,应当理解,虽然本说明书按照实施例加以描述,但并非每个实施例仅包含一个独立的技术方案,说明书的这种叙述方式仅仅是为清楚起见,本领域技术人员应当将说明书作为一个整体,各实施例中的技术方案也可以经适当组合,形成本领域技术人员可以理解的其他实施方式。In addition, it should be understood that although this specification is described in terms of embodiments, not each embodiment only contains an independent technical solution. This description of the specification is only for the sake of clarity, and those skilled in the art should take the specification as a whole. , the technical solutions in each embodiment can also be appropriately combined to form other implementations that can be understood by those skilled in the art.

Claims (1)

1. An electro-defibrillation device, comprising:
the first and second defibrillation electrodes are used for performing electric defibrillation;
the impedance detection module is electrically connected with the first and second defibrillation electrodes and is used for acquiring an impedance value between the first and second defibrillation electrodes;
the electrocardio monitoring module is electrically connected with the first and second defibrillation electrodes and is used for acquiring a real-time electrocardiogram through the first and second defibrillation electrodes;
the processor is respectively and electrically connected with the impedance detection module and the electrocardio monitoring module and is used for judging whether the impedance value is larger than a preset impedance threshold value and judging whether a normal electrocardio waveform exists in the real-time electrocardiogram; when the impedance value is larger than a preset impedance threshold value and/or normal electrocardiographic waveforms do not exist in the real-time electrocardiograph, the positions of the first and second defibrillation electrodes are adjusted; when the impedance value is smaller than or equal to a preset impedance threshold value and normal electrocardio waveforms exist in the real-time electrocardiogram, the first and second defibrillation electrodes are controlled to perform electric defibrillation;
the first and second defibrillation electrodes are respectively and electrically connected with the impedance detection module and the electrocardio monitoring module through a first switch, and the processor is also used for controlling the first switch to be turned on or off;
the electric shock inducing device further comprises a power supply processing module electrically connected with the processor and a power supply electrically connected with the power supply processing module, and the power supply processing module is electrically connected with the first shock inducing electrode and the second shock inducing electrode at the same time;
a control output module is electrically connected between the power supply processing module and the first and second defibrillation electrodes, and is electrically connected with the processor at the same time;
the first and second defibrillation electrodes are respectively and electrically connected with the control output module through a second switch, and the processor is also used for controlling the second switch to be turned on or off;
the electric shock inducing device further comprises a display interface module, a voice prompt module, a storage recording module and a key operation module which are electrically connected with the processor.
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