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CN111657927A - Electric flutter-inducing method and device - Google Patents

Electric flutter-inducing method and device Download PDF

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CN111657927A
CN111657927A CN202010699863.8A CN202010699863A CN111657927A CN 111657927 A CN111657927 A CN 111657927A CN 202010699863 A CN202010699863 A CN 202010699863A CN 111657927 A CN111657927 A CN 111657927A
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CN111657927B (en
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刁孟元
朱英
胡炜
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Hangzhou First Peoples Hospital
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
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Abstract

本发明揭示了一种电诱颤方法及装置,其中,电诱颤方法,包括:获取第一诱颤电极和第二诱颤电极之间的阻抗值,通过第一诱颤电极和第二诱颤电极获取实时心电图;判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。本发明通过电极间的心电、阻抗信息判断诱颤电极位置是否正确,提供了最直接的判断依据,最直接的反映了电极的位置,且无需监护仪设备或者造影设备即可判断电极位置。

Figure 202010699863

The present invention discloses a method and device for electric induction, wherein the method for electric induction includes: obtaining an impedance value between a first induction electrode and a second induction electrode, and through the first induction electrode and the second induction electrode Obtain a real-time ECG with the fibrillation electrode; determine whether the impedance value is greater than a preset impedance threshold, and determine whether there is a normal ECG waveform in the real-time ECG; when the impedance value is greater than the preset impedance threshold and/or there is no normal ECG waveform in the real-time ECG, Adjust the positions of the first and second inducement electrodes; when the impedance value is less than or equal to the preset impedance threshold and there is a normal ECG waveform in the real-time ECG, control the first and second inducement electrodes Conduct electrical inducement. The invention judges whether the position of the defibrillation electrode is correct through the electrocardiogram and impedance information between the electrodes, provides the most direct judgment basis, most directly reflects the position of the electrode, and can judge the position of the electrode without monitoring equipment or angiography equipment.

Figure 202010699863

Description

电诱颤方法及装置Method and device for electrical induction of fibrillation

技术领域technical field

本发明属于动物实验领域,具体涉及一种电诱颤方法及装置。The invention belongs to the field of animal experiments, and in particular relates to an electrical inducement method and device.

背景技术Background technique

在医学临床的动物实验过程中,经常需要使得实验动物对象产生非正常心律,以模拟患病的心律条件,来验证医疗器械或者药物的安全性、有效性。其中最常见的是使得实验动物产生室颤心律;例如,在对除颤仪、AED等除颤设备进行动物实验时,必须要使动物产生可除颤心律(通常是室颤心律),除颤仪、AED等除颤设备才有了实验治疗对象,才能触发设备进行除颤操作。因此,在这类动物实验中,对实验动物进行诱颤,即诱发室颤,是进行动物实验准备的关键操作。In the process of animal experiments in medical clinics, it is often necessary to make experimental animal subjects generate abnormal heart rhythms to simulate diseased heart rhythm conditions to verify the safety and effectiveness of medical devices or drugs. Among them, the most common is to make experimental animals produce ventricular fibrillation rhythm; for example, when animal experiments are performed on defibrillator, AED and other defibrillation equipment, animals must produce defibrillable rhythm (usually ventricular fibrillation rhythm), defibrillation Only when defibrillation equipment such as instrument and AED have experimental treatment objects can the equipment be triggered to perform defibrillation operations. Therefore, in this kind of animal experiment, to induce fibrillation in experimental animals, that is, to induce ventricular fibrillation, is the key operation for animal experiment preparation.

诱颤有多种方法,例如,药物诱颤,窒息诱颤,电诱颤。其中药物诱颤和窒息诱颤会对动物的心肌等组织造成损伤,形成了动物实验过程的干扰因素;例如,在除颤设备的动物实验流程中,需要对除颤治疗结束的动物心肌进行切片检验,其检验结果会作为分析除颤设备安全性的重要因素,而药物诱颤和窒息诱颤对心肌组织的影响会干扰这一项分析。There are many ways to induce tremors, for example, drug-induced tremors, asphyxia-induced tremors, and electrical tremors. Among them, drug-induced fibrillation and suffocation-induced fibrillation will cause damage to the myocardium and other tissues of animals, forming interference factors in the animal experiment process; for example, in the animal experiment process of defibrillation equipment, it is necessary to slice the animal myocardium after defibrillation treatment. The test results will be an important factor in the analysis of the safety of defibrillation equipment, and the effects of drug-induced defibrillation and asphyxia-induced defibrillation on myocardial tissue may interfere with this analysis.

电诱颤是一种优秀的诱发动物发生室颤的方法,其对动物的影响干扰程度较小。但是,当前实验室用的电诱颤方法通常比较粗放,没有进行精确的控制,而且诱颤容易失败,需要反复尝试多次才能诱颤成功,这取决于与实验操作人员的熟练程度。Electrically induced fibrillation is an excellent method for inducing ventricular fibrillation in animals, and its effect on animals is less disturbing. However, the current electrical inducement methods used in the laboratory are usually rough, without precise control, and the inducement is easy to fail, requiring repeated attempts to induce a successful inducement, which depends on the proficiency of the experimental operator.

因此,针对上述技术问题,有必要提供一种电诱颤方法及装置。Therefore, in view of the above technical problems, it is necessary to provide a method and device for electrical induction.

发明内容SUMMARY OF THE INVENTION

有鉴于此,本发明的目的在于提供一种电诱颤方法及装置,以实现对电诱颤的精准控制。In view of this, the purpose of the present invention is to provide a method and device for electric induction, so as to realize precise control of electric induction.

为了实现上述目的,本发明一实施例提供的技术方案如下:In order to achieve the above purpose, the technical solution provided by an embodiment of the present invention is as follows:

一种电诱颤方法,包括以下步骤:A method for electrical induction of fibrillation, comprising the following steps:

获取第一诱颤电极和第二诱颤电极之间的阻抗值,通过第一诱颤电极和第二诱颤电极获取实时心电图;acquiring the impedance value between the first inducement electrode and the second inducement electrode, and acquiring a real-time electrocardiogram through the first inducement electrode and the second inducement electrode;

判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;Determine whether the impedance value is greater than the preset impedance threshold, and determine whether there is a normal ECG waveform in the real-time ECG;

当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;When the impedance value is greater than the preset impedance threshold and/or there is no normal ECG waveform in the real-time ECG, adjusting the positions of the first defibrillation electrode and the second defibrillation electrode;

当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。When the impedance value is less than or equal to the preset impedance threshold and there is a normal ECG waveform in the real-time electrocardiogram, control the first defibrillation electrode and the second defibrillation electrode to perform electrical induction.

一实施例中,“控制第一诱颤电极和第二诱颤电极进行电诱颤”在恒压或恒流模式下进行。In one embodiment, "controlling the first defibrillation electrode and the second defibrillation electrode to perform electrical defibrillation" is performed in a constant voltage or constant current mode.

一实施例中,“控制第一诱颤电极和第二诱颤电极进行电诱颤”具体为:In one embodiment, "controlling the first defibrillation electrode and the second defibrillation electrode to perform electrical induction" is specifically:

在自动模式下,当阻抗值小于或等于预设阻抗阈值且实时心电图中不存在正常心电波形时,等待时间t1,自动开始电诱颤,维持电诱颤时间t11后,停止电诱颤,监测实时心电图中是否存在室颤心率波形,如否,则继续电诱颤,如是,则电诱颤成功,记录数据参数;In the automatic mode, when the impedance value is less than or equal to the preset impedance threshold and there is no normal ECG waveform in the real-time ECG, wait for time t1, and automatically start the electrical induction. After maintaining the electric induction for time t11, stop the electric induction. Monitor whether there is a ventricular fibrillation heart rate waveform in the real-time ECG, if not, continue the electrical inducement, if so, the electrical inducement is successful, and record the data parameters;

在半自动模式下,当阻抗值小于或等于预设阻抗阈值且实时心电图中不存在正常心电波形时,等待时间t2,手动开始电诱颤,维持电诱颤时间t21后,监测实时心电图中是否存在室颤心率波形,如否,则继续电诱颤,如是,则电诱颤成功,记录数据参数。In the semi-automatic mode, when the impedance value is less than or equal to the preset impedance threshold and there is no normal ECG waveform in the real-time ECG, wait for time t2, manually start the electric induction, and maintain the electric induction after t21, and monitor whether the real-time ECG is There is a ventricular fibrillation heart rate waveform, if not, continue the electrical induction; if so, the electric induction is successful, and record the data parameters.

本发明另一实施例提供的技术方案如下:The technical solution provided by another embodiment of the present invention is as follows:

一种电诱颤装置包括:An electrical inducement device comprising:

第一诱颤电极和第二诱颤电极,用于进行电诱颤;a first inducement electrode and a second inducement electrode for conducting electrical inducement;

阻抗检测模块,与第一诱颤电极和第二诱颤电极电性连接,用于获取第一诱颤电极和第二诱颤电极之间的阻抗值;an impedance detection module, electrically connected to the first defibrillation electrode and the second defibrillation electrode, for acquiring the impedance value between the first defibrillation electrode and the second defibrillation electrode;

心电监测模块,与第一诱颤电极和第二诱颤电极电性连接,用于通过第一诱颤电极和第二诱颤电极获取实时心电图;an ECG monitoring module, electrically connected to the first inducement electrode and the second inducement electrode, for acquiring a real-time electrocardiogram through the first inducement electrode and the second inducement electrode;

处理器,分别与阻抗检测模块和心电监测模块电性连接,用于判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。The processor is electrically connected to the impedance detection module and the ECG monitoring module respectively, and is used to judge whether the impedance value is greater than the preset impedance threshold value, and judge whether there is a normal ECG waveform in the real-time electrocardiogram; when the impedance value is greater than the preset impedance threshold value and / or when there is no normal ECG waveform in the real-time ECG, adjust the positions of the first and second inducement electrodes; when the impedance value is less than or equal to the preset impedance threshold and there is a normal ECG waveform in the real-time ECG , and control the first and second inducer electrodes to conduct electrical inducement.

另一实施例中,所述第一诱颤电极和第二诱颤电极分别通过第一开关与阻抗检测模块和心电监测模块电性连接,所述处理器还用于控制第一开关的开启或关闭。In another embodiment, the first defibrillation electrode and the second defibrillation electrode are electrically connected to the impedance detection module and the ECG monitoring module through a first switch, respectively, and the processor is further configured to control the opening of the first switch. or off.

另一实施例中,所述电诱颤装置还包括与处理器电性连接的电源处理模块以及与电源处理模块电性连接的电源,所述电源处理模块同时与第一诱颤电极和第二诱颤电极电性连接。In another embodiment, the electrical induction device further includes a power processing module electrically connected to the processor and a power supply electrically connected to the power processing module, the power processing module being connected to the first defibrillation electrode and the second at the same time. The defibrillation electrodes are electrically connected.

另一实施例中,所述电源处理模块与第一诱颤电极、第二诱颤电极之间电性连接有控制输出模块,所述控制输出模块同时与处理器电性连接。In another embodiment, a control output module is electrically connected between the power processing module, the first defibrillation electrode and the second defibrillation electrode, and the control output module is electrically connected to the processor at the same time.

另一实施例中,所述第一诱颤电极和第二诱颤电极分别通过第二开关与控制输出模块电性连接,所述处理器还用于控制第二开关的开启或关闭。In another embodiment, the first defibrillation electrode and the second defibrillation electrode are electrically connected to the control output module through a second switch, respectively, and the processor is further configured to control turning on or off of the second switch.

另一实施例中,所述电诱颤装置还包括与处理器电性连接的显示界面模块、语音提示模块、存储记录模块和按键操作模块。In another embodiment, the electrical induction device further includes a display interface module, a voice prompt module, a storage recording module and a key operation module electrically connected to the processor.

与现有技术相比,本发明具有以下优点:Compared with the prior art, the present invention has the following advantages:

本发明通过诱颤电极间的心电、阻抗信息判断诱颤电极位置是否正确,提供了最直接的判断依据,最直接的反映了诱颤电极的位置,即与心室内壁接触就有正常心电且阻抗小,否则就没有接触,简单有效,且无需更多其它监护仪设备或者造影设备即可判断电极位置。The present invention judges whether the position of the defibrillation electrodes is correct through the electrocardiogram and impedance information between the defibrillation electrodes, provides the most direct judgment basis, and most directly reflects the position of the defibrillation electrodes. And the impedance is small, otherwise there is no contact, it is simple and effective, and the electrode position can be judged without more other monitoring equipment or imaging equipment.

附图说明Description of drawings

为了更清楚地说明本申请实施例或现有技术中的技术方案,下面将对实施例或现有技术描述中所需要使用的附图作简单地介绍,显而易见地,下面描述中的附图仅仅是本申请中记载的一些实施例,对于本领域普通技术人员来讲,在不付出创造性劳动的前提下,还可以根据这些附图获得其他的附图。In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the accompanying drawings required for the description of the embodiments or the prior art. Obviously, the drawings in the following description are only These are some embodiments described in this application. For those of ordinary skill in the art, other drawings can also be obtained based on these drawings without any creative effort.

图1为本发明一实施例中电诱颤的流程图;Fig. 1 is the flow chart of electric induced fibrillation in one embodiment of the present invention;

图2为本发明一实施例中电诱颤装置的电路结构示意图;FIG. 2 is a schematic diagram of a circuit structure of an electrical inducement device in an embodiment of the present invention;

图3为本发明一实施例中控制输出模块输出的电压波形图;3 is a voltage waveform diagram of a control output module output in an embodiment of the present invention;

图4为本发明一实施例中控制输出模块输出的电流波形图。FIG. 4 is a waveform diagram of a current output by a control output module according to an embodiment of the present invention.

具体实施方式Detailed ways

以下将结合附图所示的各实施方式对本发明进行详细描述。但该等实施方式并不限制本发明,本领域的普通技术人员根据该等实施方式所做出的结构、方法、或功能上的变换均包含在本发明的保护范围内。The present invention will be described in detail below with reference to the various embodiments shown in the accompanying drawings. However, these embodiments do not limit the present invention, and the structural, method, or functional transformations made by those of ordinary skill in the art based on these embodiments are all included in the protection scope of the present invention.

本发明公开了一种电诱颤方法,包括以下步骤:The invention discloses a method for electrical induction of fibrillation, comprising the following steps:

获取第一诱颤电极和第二诱颤电极之间的阻抗值,通过第一诱颤电极和第二诱颤电极获取实时心电图;acquiring the impedance value between the first inducement electrode and the second inducement electrode, and acquiring a real-time electrocardiogram through the first inducement electrode and the second inducement electrode;

判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;Determine whether the impedance value is greater than the preset impedance threshold, and determine whether there is a normal ECG waveform in the real-time ECG;

当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;When the impedance value is greater than the preset impedance threshold and/or there is no normal ECG waveform in the real-time ECG, adjusting the positions of the first defibrillation electrode and the second defibrillation electrode;

当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。When the impedance value is less than or equal to the preset impedance threshold and there is a normal ECG waveform in the real-time electrocardiogram, control the first defibrillation electrode and the second defibrillation electrode to perform electrical induction.

以下结合具体实施例对本发明作进一步说明。The present invention will be further described below in conjunction with specific embodiments.

参图1所示,本发明公开了一种电诱颤方法,包括以下步骤:Referring to Figure 1, the present invention discloses a method for electrical induction, comprising the following steps:

获取第一诱颤电极和第二诱颤电极之间的阻抗值,通过第一诱颤电极和第二诱颤电极获取实时心电图;acquiring the impedance value between the first inducement electrode and the second inducement electrode, and acquiring a real-time electrocardiogram through the first inducement electrode and the second inducement electrode;

判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;Determine whether the impedance value is greater than the preset impedance threshold, and determine whether there is a normal ECG waveform in the real-time ECG;

当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极和第二诱颤电极的位置进行调整;When the impedance value is greater than the preset impedance threshold and/or there is no normal ECG waveform in the real-time ECG, adjusting the positions of the first defibrillation electrode and the second defibrillation electrode;

当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极和第二诱颤电极进行电诱颤。When the impedance value is less than or equal to the preset impedance threshold and there is a normal ECG waveform in the real-time electrocardiogram, control the first defibrillation electrode and the second defibrillation electrode to perform electrical induction.

其中,预设阻抗阈值为10kΩ。The preset impedance threshold is 10kΩ.

本实施例中,控制第一诱颤电极和第二诱颤电极在恒压或者恒流模式下进行电诱颤。In this embodiment, the first inducement electrode and the second inducement electrode are controlled to perform electrical inducement in a constant voltage or constant current mode.

本实施例中,在自动模式下,当阻抗值小于或等于10kΩ且实时心电图中存在正常心电波形时,等待时间t1,自动开始电诱颤,维持电诱颤时间t11后,停止电诱颤,监测实时心电图中是否存在室颤心率波形,如否,则继续电诱颤,如是,则电诱颤成功,记录数据参数;In this embodiment, in the automatic mode, when the impedance value is less than or equal to 10kΩ and there is a normal ECG waveform in the real-time ECG, wait for a time t1, and automatically start the electric induction, and after maintaining the electric induction for a time t11, stop the electric induction , to monitor whether there is a ventricular fibrillation heart rate waveform in the real-time ECG, if not, continue the electrical inducement, if so, the electrical inducement is successful, and record the data parameters;

在半自动模式下,当阻抗值小于或等于10kΩ且实时心电图中存在正常心电波形时,等待时间t2,手动开始电诱颤,维持电诱颤时间t21后,监测实时心电图中是否存在室颤心率波形,如否,则继续电诱颤,如是,则电诱颤成功,记录数据参数。In the semi-automatic mode, when the impedance value is less than or equal to 10kΩ and there is a normal ECG waveform in the real-time ECG, wait for time t2, manually start the electrical inducement, and after maintaining the electrical inducement time t21, monitor whether there is ventricular fibrillation heart rate in the real-time ECG Waveform, if not, continue to induce electrical inducement, if yes, electrical inducement is successful, and record data parameters.

数据参数记录内容包括:1.全过程监测到的心电波形,2.第一诱颤电极和第二诱颤电极之间的阻抗值,3.诱颤模式:恒压模式/恒流模式,自动模式/半自动模式,4.诱颤次数,5.每一次诱颤的诱颤电压值(恒压模式下即为V值,恒流模式下为I与阻抗值的乘积)和电流值(恒压模式下为V与阻抗值之间的比值,恒流模式下即为I值)。6.心率即恒压/恒流的诱颤方波频率值。The contents of data parameter recording include: 1. ECG waveforms monitored in the whole process, 2. Impedance value between the first and second defibrillation electrodes, 3. Defibrillation mode: constant voltage mode/constant current mode, Automatic mode/semi-automatic mode, 4. The number of decoys, 5. The decoy voltage value (V value in constant voltage mode, the product of I and impedance value in constant current mode) and current value (constant In voltage mode, it is the ratio between V and impedance value, and in constant current mode, it is the I value). 6. Heart rate is the frequency value of the constant voltage/constant current induced vibration square wave.

参图2所示,本发明还公开了一种电诱颤装置,包括:用于进行电诱颤的第一诱颤电极A和第二诱颤电极B、用于获取第一诱颤电极A和第二诱颤电极B之间的阻抗值的阻抗检测模块、用于通过第一诱颤电极A和第二诱颤电极B获取实时心电图的心电监测模块以及处理器CPU。Referring to FIG. 2, the present invention also discloses an electrical inducement device, comprising: a first inducement electrode A and a second inducement electrode B for conducting electrical inducement, and a first inducement electrode A for obtaining An impedance detection module for the impedance value between the first and the second defibrillation electrode B, an ECG monitoring module for acquiring a real-time electrocardiogram through the first defibrillation electrode A and the second defibrillation electrode B, and a processor CPU.

具体的,其中一个诱颤电极放置在动物皮肤表面离心脏较近的位置、另一个诱颤电极通过有创插管被放置到与动物心室内壁接触,阻抗检测模块与第一诱颤电极A和第二诱颤电极B电性连接,心电监测模块与第一诱颤电极A和第二诱颤电极B电性连接,第一诱颤电极A和第二诱颤电极B分别通过第一开关K1与阻抗检测模块和心电监测模块电性连接。Specifically, one of the defibrillation electrodes is placed on the skin surface of the animal closer to the heart, the other defibrillation electrode is placed in contact with the inner wall of the animal's ventricle through an invasive cannula, and the impedance detection module is connected to the first defibrillation electrode A and The second inducement electrode B is electrically connected, the ECG monitoring module is electrically connected to the first inducement electrode A and the second inducement electrode B, and the first inducement electrode A and the second inducement electrode B pass through the first switch respectively. K1 is electrically connected with the impedance detection module and the ECG monitoring module.

参图2所示,处理器CPU分别与阻抗检测模块和心电监测模块电性连接,处理器CPU用于判断阻抗值是否大于预设阻抗阈值,并判断实时心电图中是否存在正常心电波形;当阻抗值大于预设阻抗阈值和/或实时心电图中不存在正常心电波形时,对第一诱颤电极A和第二诱颤电极B的位置进行调整;当阻抗值小于或等于预设阻抗阈值且实时心电图中存在正常心电波形时,控制第一诱颤电极A和第二诱颤电极B进行电诱颤,处理器CPU还用于控制第一开关K1的开启或关闭,从而控制阻抗检测模块和心电监测模块与第一诱颤电极A、第一诱颤电极B之间的断开和连接。Referring to Figure 2, the processor CPU is electrically connected to the impedance detection module and the ECG monitoring module, respectively, and the processor CPU is used to judge whether the impedance value is greater than the preset impedance threshold value, and to judge whether there is a normal ECG waveform in the real-time electrocardiogram; When the impedance value is greater than the preset impedance threshold and/or there is no normal ECG waveform in the real-time ECG, adjust the positions of the first defibrillation electrode A and the second defibrillation electrode B; when the impedance value is less than or equal to the preset impedance Threshold value and when there is a normal ECG waveform in the real-time ECG, control the first inducement electrode A and the second inducement electrode B to conduct electrical inducement, and the processor CPU is also used to control the opening or closing of the first switch K1, thereby controlling the impedance The disconnection and connection between the detection module and the ECG monitoring module, and the first defibrillation electrode A and the first defibrillation electrode B.

参图2所示,电诱颤装置还包括与处理器CPU电性连接的电源处理模块以及与电源处理模块电性连接的电源,电源为市电(交流电220V),电源处理模块同时与第一诱颤电极A和第二诱颤电极B电性连接,电源处理模块与第一诱颤电极A、第二诱颤电极B之间电性连接有控制输出模块,控制输出模块同时与处理器CPU电性连接,第一诱颤电极A和第二诱颤电极B分别通过第二开关K2与控制输出模块电性连接,处理器CPU还用于控制第二开关K2的开启或关闭,从而控制控制输出模块与第一诱颤电极A和第一诱颤电极B之间的断开和连接。Referring to Fig. 2, the electric tremor induction device also includes a power supply processing module electrically connected with the processor CPU and a power supply electrically connected with the power supply processing module, the power supply is commercial power (AC 220V), and the power supply processing module is simultaneously connected with the first power supply processing module. The lubricating electrode A and the second lubricating electrode B are electrically connected, and a control output module is electrically connected between the power processing module and the first lubricating electrode A and the second lubricating electrode B, and the control output module is simultaneously connected to the processor CPU. Electrical connection, the first decoy electrode A and the second decoy electrode B are respectively electrically connected to the control output module through the second switch K2, and the processor CPU is also used to control the opening or closing of the second switch K2, thereby controlling the control The disconnection and connection between the output module and the first inducement electrode A and the first inducement electrode B.

本实施例中,处理器CPU采用的芯片为STM32F103VGT6,心电监测模块采用的芯片为ADS1198,阻抗检测模块采用的芯片为AD5934。In this embodiment, the chip used by the processor CPU is STM32F103VGT6, the chip used by the ECG monitoring module is ADS1198, and the chip used by the impedance detection module is AD5934.

参图2所示,电诱颤装置还包括与处理器CPU电性连接的显示界面模块、语音提示模块、存储记录模块和按键操作模块,显示模块采用的芯片为SSD1963QL9,语音提示模块采用的芯片为KT1025A。As shown in Fig. 2, the electric trembling device also includes a display interface module, a voice prompt module, a storage recording module and a key operation module electrically connected with the processor CPU, the chip adopted by the display module is SSD1963QL9, and the chip adopted by the voice prompt module. For KT1025A.

其中,电源处理模块用于对电源进行降压、整流等处理后,为处理器CPU、显示界面模块、语音提示模块、存储记录模块和按键操作模块等供电,同时也为控制输出模块提供诱颤电源。Among them, the power processing module is used to provide power for the processor CPU, display interface module, voice prompt module, storage recording module and key operation module after the power supply is reduced, rectified, etc., and also provides decoys for the control output module. power supply.

本实施例中,控制输出模块用于将电源处理模块提供的诱颤电源调整成所需的对应的诱颤电压或诱颤电流并直接输出到第一诱颤电极A和第一诱颤电极B。In this embodiment, the control output module is used to adjust the defibrillation power supply provided by the power supply processing module to the required corresponding defibrillation voltage or defibrillation current and directly output it to the first defibrillation electrode A and the first defibrillation electrode B .

本实施例中,按键操作模块包括恒压模式按钮、恒流模式按钮、自动模式按钮、半自动模式按钮、启动诱颤按钮、电压调节旋钮以及电流调节旋钮,用于控制处理器CPU进入恒压模式/恒流模式、自动模式/半自动模式以及启动诱颤,并对电压和电流进行调节。In this embodiment, the key operation module includes a constant voltage mode button, a constant current mode button, an automatic mode button, a semi-automatic mode button, a start defibrillation button, a voltage adjustment knob and a current adjustment knob, which are used to control the processor CPU to enter the constant voltage mode /Constant current mode, automatic mode/semi-automatic mode and start the decoy, and adjust the voltage and current.

半自动模式和自动模式,可以根据不同的熟练程度进行选择,提供了操作效率;且两种模式下,均可根据诱颤结果的提示进行操作,非常方便。Semi-automatic mode and automatic mode can be selected according to different proficiency levels, which provides operation efficiency; and in both modes, the operation can be performed according to the prompts of the inducement results, which is very convenient.

参图3所示,在恒压模式下,在处理器CPU的控制下控制输出模块将电源处理模块的输出转化为恒压输出的双向方波(50:50),在诱颤过程中,其方波幅值为恒定V(恒定即:无论阻抗检测的值为多少或者如何变化,且在诱颤过程中无论控制输出的负载有任何的扰动和变化,其输出的电压幅值恒定为V,而电流随负载或阻抗进行调节变化),V值可通过电压调节旋钮预先进行设定,其中V值调节范围优选为1V至12V,方波的周期为T(频率f=1/T),方波频率优选的值为心电监测模块所获取的心电心率值,方波频率与心率值相等,恒压模式下,恒流模式按钮、电流调节旋钮不工作。Referring to Figure 3, in the constant voltage mode, under the control of the processor CPU, the output module is controlled to convert the output of the power processing module into a bidirectional square wave (50:50) output by constant voltage. The amplitude of the square wave is constant V (constant that is: no matter how much the impedance detection value is or how it changes, and no matter there is any disturbance and change in the load of the control output during the induction process, the output voltage amplitude is constant V, The current is adjusted and changed with the load or impedance), the V value can be preset through the voltage adjustment knob, and the V value adjustment range is preferably 1V to 12V, the period of the square wave is T (frequency f=1/T), the square wave The preferred value of the wave frequency is the heart rate value obtained by the ECG monitoring module. The frequency of the square wave is equal to the heart rate value. In the constant voltage mode, the constant current mode button and the current adjustment knob do not work.

参图4所示,在恒流模式下,在处理器CPU的控制下控制输出模块将电源处理模块的输出转化为恒流输出的双向方波(50:50),在诱颤过程中,其电流方波幅值为恒定I(恒定即:无论阻抗检测的值为多少或者如何变化,且在诱颤过程中无论控制输出的负载有任何的扰动和变化,其输出的电流幅值恒定为I,而电压随负载或阻抗进行调节变化),I值可通过电流调节旋钮预先进行设定,其中I值调节范围优选为1mA至20mA,方波的周期为T(频率f=1/T),方波频率优选的值为心电监测模块所获取的心电心率值,方波频率与心率值相等,恒流模式下,恒压模式按钮、电压调节旋钮不工作。Referring to Fig. 4, in the constant current mode, under the control of the processor CPU, the output module is controlled to convert the output of the power processing module into a bidirectional square wave (50:50) output by constant current. The amplitude of the current square wave is constant I (constant that is: no matter how much the impedance detection value is or how it changes, and no matter there is any disturbance and change in the load of the control output during the induction process, the output current amplitude is constant I , and the voltage is adjusted and changed with the load or impedance), the I value can be preset through the current adjustment knob, where the I value adjustment range is preferably 1mA to 20mA, and the period of the square wave is T (frequency f=1/T), The preferred value of the square wave frequency is the heart rate value obtained by the ECG monitoring module. The frequency of the square wave is equal to the heart rate value. In the constant current mode, the constant voltage mode button and the voltage adjustment knob do not work.

恒压模式和恒流模式下精确的输出波形,诱颤参数稳定、确定,在多个动物实验的对比中,不会形成干扰因素。Accurate output waveforms in constant voltage mode and constant current mode, stable and definite parameters of inducement, and no interference factors will be formed in the comparison of multiple animal experiments.

本实施例中,存储记录模块用于存储电诱颤过程中的参数,包括:诱颤电流曲线、诱颤电压曲线、阻抗记录、诱颤持续时间记录、诱颤结果、诱颤次数,多项诱颤参数的记录,便于多个动物实验对比时,作为数据分析、分组的依据,提供了更多的实验分析所需的数据。In this embodiment, the storage and recording module is used to store the parameters in the process of electric induction, including: induction current curve, induction voltage curve, impedance record, induction duration record, induction result, frequency of induction, multiple The recording of the induced tremor parameters is convenient for the comparison of multiple animal experiments, as a basis for data analysis and grouping, and provides more data required for experimental analysis.

本实施例中,语言提示装置用于语音提示按键操作模块的设置模式,在诱颤过程中提示操作步骤和操作动作。In this embodiment, the language prompting device is used for voice prompting the setting mode of the key operation module, and prompts the operation steps and operation actions during the induced tremor.

本实施例中,显示界面模块用于显示按键操作模块的设置模式,实时显示经第一诱颤电极A和第一诱颤电极B采集的心电图、显示诱颤持续的时间、显示已经进行的诱颤次数和当前的诱颤结果。In this embodiment, the display interface module is used to display the setting mode of the key operation module, display the electrocardiogram collected by the first inducement electrode A and the first inducement electrode B in real time, display the duration of inducement, and display the induced inducement that has already been performed. The number of tremors and the current lure result.

通过语音和界面显示不断的提示和指导诱颤操作,增加了使用的便利性。Continuous prompts and guidance for decoy operations are displayed through voice and interface, increasing the convenience of use.

参图1并结合图2所示,当第一诱颤电极A和B准备待用后,闭合第一开关K1维持第二开关K2为断开,心电监测模块获取实时心电图、阻抗检测模块获取第一诱颤电极A和第一诱颤电极B之间的阻抗值;处理器CPU识别心电图信息和阻抗值,当识别到心电图属于非正常心电波形或者阻抗值大于10K这两个设定的条件之一时,说明第一诱颤电极A和第一诱颤电极B之间没有心电图信息,即表明心内置管的诱颤电极未与心室内壁接触,此时发出语音提示置管诱颤电极位置不对,需要重新调整其位置;经过反复判断和调整,直至上述的两个设定的条件均没有发生,说明心内置管的诱颤电极与心室内壁接触良好,此时语音提示诱颤电极位置良好需要固定电极位置,并同时界面显示通过第一诱颤电极A和第一诱颤电极B获取的心电图以及具体的阻抗值。Referring to Fig. 1 in conjunction with Fig. 2, when the first defibrillation electrodes A and B are ready to be used, the first switch K1 is closed to keep the second switch K2 disconnected, and the ECG monitoring module obtains a real-time ECG and the impedance detection module obtains. The impedance value between the first lubricating electrode A and the first lubricating electrode B; the processor CPU identifies the ECG information and the impedance value, and when it is identified that the ECG belongs to an abnormal ECG waveform or the impedance value is greater than 10K, these two settings In one of the conditions, it means that there is no ECG information between the first inducement electrode A and the first inducement electrode B, which means that the inducement electrode of the intracardiac catheter is not in contact with the inner wall of the ventricle. No, its position needs to be re-adjusted; after repeated judgment and adjustment, until the above two set conditions do not occur, it means that the intracardiac catheter's defibrillation electrodes are in good contact with the inner wall of the ventricle. The electrode position needs to be fixed, and at the same time, the interface displays the electrocardiogram and specific impedance values obtained by the first inducement electrode A and the first inducement electrode B.

完成上述第一诱颤电极A和第一诱颤电极B的位置放置后,如果选择为半自动模式下,则等待时间t2,时间t2优选值为5秒,等待时间t2结束后,语音提示和界面显示:可诱颤并请按下启动诱颤按钮;当检测到启动诱颤按钮被按下后,则断开第一开关K1并闭合第二开关K2,维持诱颤输出,经过时间t21,优选的时间t21为3秒,时间t21结束后,闭合第一开关K1并断开第二开关K2,然后处理器CPU立即监测识别心电波形是否为室颤心律波形,如果不是室颤心律波形,即重复等待时间t2及后续的过程;直至处理器CPU识别到室颤心律波形,此时界面显示室颤心律波形并语音提示诱颤成功,并记录上述过程中的诱颤参数值。After completing the placement of the first decoupling electrode A and the first decoying electrode B, if the semi-automatic mode is selected, wait time t2, the preferred value of time t2 is 5 seconds, after the waiting time t2 ends, the voice prompt and interface Display: Decoy is available and please press the start defibrillation button; when it is detected that the start decoy button is pressed, the first switch K1 is turned off and the second switch K2 is closed to maintain the decoy output, after time t21, preferably The time t21 is 3 seconds. After the time t21 is over, the first switch K1 is closed and the second switch K2 is disconnected. Then the processor CPU immediately monitors and identifies whether the ECG waveform is a ventricular fibrillation rhythm waveform. If it is not a ventricular fibrillation rhythm waveform, that is The waiting time t2 and subsequent processes are repeated until the processor CPU recognizes the ventricular fibrillation rhythm waveform. At this time, the interface displays the ventricular fibrillation rhythm waveform and voice prompts that the fibrillation is successful, and records the fibrillation parameter values in the above process.

完成上述诱颤电极的位置放置后,如果选择为自动模式下,则等待一段时间t1,时间t1优选值为15秒,等待时间t1结束后,语音提示和界面显示:可诱颤并于等待10后开始诱颤请勿干扰;当等待10秒倒计时结束后,自动断开第一开关K1并闭合第二开关K2,并维持诱颤输出,经过时间t11,优选的时间t11时间为3秒,时间t11结束后,闭合第一开关K1并断开第二开关K2,然后处理器CPU立即监测识别心电波形是否为室颤心律波形,如果不是室颤心律波形,即重复等待时间t1及后续的过程;直至处理器CPU识别到室颤心律波形,此时界面显示室颤心律波形并语音提示诱颤成功,并记录上述过程中的诱颤参数值。After completing the placement of the above-mentioned decoy electrodes, if the automatic mode is selected, wait for a period of time t1. The preferred value of time t1 is 15 seconds. After the waiting time t1 is over, the voice prompt and interface display: You can induce tremors and wait for 10 seconds. Do not interfere with the induced tremor; when the 10-second countdown is over, the first switch K1 is automatically turned off and the second switch K2 is closed, and the tremor output is maintained. After time t11, the preferred time t11 is 3 seconds, and the time After the end of t11, close the first switch K1 and open the second switch K2, and then the processor CPU immediately monitors and identifies whether the ECG waveform is a ventricular fibrillation rhythm waveform. If it is not a ventricular fibrillation rhythm waveform, repeat the waiting time t1 and subsequent processes ; Until the processor CPU recognizes the ventricular fibrillation rhythm waveform, at this time the interface displays the ventricular fibrillation rhythm waveform and voice prompts the success of the induced fibrillation, and records the induced fibrillation parameter values in the above process.

参数记录内容包括:1.全过程的心电监测模块监测到的心电波形;2.诱颤电极间的阻抗值;3.诱颤模式:恒压模式/恒流模式,自动模式/半自动模式;4.诱颤次数;5.每一次诱颤的诱颤电压值(恒压模式下即为V值,恒流模式下为I与阻抗值的乘积)和电流值(恒压模式下为V与阻抗值之间的比值,恒流模式下即为I值);6.心率即恒压/恒流的诱颤方波频率值。The content of parameter record includes: 1. ECG waveform monitored by the ECG monitoring module in the whole process; 2. Impedance value between the decoy electrodes; 3. Decoy mode: constant voltage mode/constant current mode, automatic mode/semi-automatic mode ; 4. The number of induced tremors; 5. The induced tremor voltage value (the V value in the constant voltage mode, the product of the I and the impedance value in the constant current mode) and the current value (V in the constant voltage mode) The ratio between the impedance value and the constant current mode is the I value); 6. The heart rate is the frequency value of the constant voltage/constant current inducement square wave.

本实施例中,自动模式和半自动模式下,均可以输出恒流模式下或者恒压模式下设定的诱颤输出的双向方波。In this embodiment, in both the automatic mode and the semi-automatic mode, the bidirectional square wave of the decoy output set in the constant current mode or the constant voltage mode can be output.

由以上技术方案可以看出,本发明具有以下有益效果:As can be seen from the above technical solutions, the present invention has the following beneficial effects:

本发明通过第一诱颤电极和第二诱颤电极之间的心电波形、阻抗信息判断电极的位置是否正确,提供了最直接的判断依据,最直接的反映了电极的位置,即与心室内壁接触就有正常心电且阻抗小,否则就没有接触,简单有效;且无需更多其它监护仪设备或者造影设备即可判断电极位置。The present invention judges whether the position of the electrodes is correct by using the ECG waveform and impedance information between the first and the second defibrillation electrodes, and provides the most direct judgment basis, which most directly reflects the position of the electrodes, that is, the relationship between the electrodes and the ventricle. If the inner wall is in contact, there will be normal ECG and the impedance is small, otherwise there will be no contact, which is simple and effective; and the electrode position can be judged without more other monitoring equipment or imaging equipment.

对于本领域技术人员而言,显然本发明不限于上述示范性实施例的细节,而且在不背离本发明的精神或基本特征的情况下,能够以其他的具体形式实现本发明。因此,无论从哪一点来看,均应将实施例看作是示范性的,而且是非限制性的,本发明的范围由所附权利要求而不是上述说明限定,因此旨在将落在权利要求的等同要件的含义和范围内的所有变化囊括在本发明内。不应将权利要求中的任何附图标记视为限制所涉及的权利要求。It will be apparent to those skilled in the art that the present invention is not limited to the details of the above-described exemplary embodiments, but that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics of the invention. Therefore, the embodiments are to be regarded in all respects as illustrative and not restrictive, and the scope of the invention is defined by the appended claims rather than the foregoing description, which are therefore intended to fall within the scope of the appended claims. All changes within the meaning and scope of the equivalents of , are included in the present invention. Any reference signs in the claims shall not be construed as limiting the involved claim.

此外,应当理解,虽然本说明书按照实施例加以描述,但并非每个实施例仅包含一个独立的技术方案,说明书的这种叙述方式仅仅是为清楚起见,本领域技术人员应当将说明书作为一个整体,各实施例中的技术方案也可以经适当组合,形成本领域技术人员可以理解的其他实施方式。In addition, it should be understood that although this specification is described according to embodiments, not every embodiment only includes an independent technical solution, and this description in the specification is only for the sake of clarity, and those skilled in the art should take the specification as a whole , the technical solutions in each embodiment can also be appropriately combined to form other implementations that can be understood by those skilled in the art.

Claims (9)

1. An electrical fibrillation method, comprising the steps of:
acquiring an impedance value between the first electrode and the second electrode, and acquiring a real-time electrocardiogram through the first electrode and the second electrode;
judging whether the impedance value is larger than a preset impedance threshold value or not, and judging whether a normal electrocardiogram waveform exists in the real-time electrocardiogram;
when the impedance value is larger than a preset impedance threshold value and/or normal electrocardiogram waveforms do not exist in the real-time electrocardiogram, adjusting the positions of the first and second electrode;
and when the impedance value is smaller than or equal to the preset impedance threshold value and normal electrocardiogram waveforms exist in the real-time electrocardiogram, controlling the first electrode and the second electrode to perform electric induction flutter.
2. A method of electric induction of fibrillation according to claim 1, wherein the step of controlling the first and second electrode-for-electric induction of fibrillation is performed in a constant-voltage or constant-current mode.
3. The method of claim 1, wherein the step of controlling the first and second electrodes for electrical shiver comprises:
in an automatic mode, when the impedance value is smaller than or equal to a preset impedance threshold value and normal electrocardio waveforms exist in a real-time electrocardiogram, automatically starting electrical induction flutter within a waiting time t1, stopping electrical induction flutter after maintaining the electrical induction flutter time t11, monitoring whether ventricular fibrillation heart rate waveforms exist in the real-time electrocardiogram, if not, continuing electrical induction flutter, if so, successfully inducing flutter, and recording data parameters;
in a semi-automatic mode, when the impedance value is smaller than or equal to a preset impedance threshold value and no normal electrocardiogram waveform exists in the real-time electrocardiogram, waiting for time t2, manually starting electrical induction flutter, maintaining the electrical induction flutter time t21, monitoring whether a ventricular fibrillation heart rate waveform exists in the real-time electrocardiogram, if not, continuing the electrical induction flutter, and if so, successfully inducing flutter and recording data parameters.
4. An electrical shiver apparatus, comprising:
the first electrode and the second electrode are used for electric induction;
the impedance detection module is electrically connected with the first electrode and the second electrode and used for acquiring an impedance value between the first electrode and the second electrode;
the electrocardiogram monitoring module is electrically connected with the first electrode and the second electrode and is used for acquiring a real-time electrocardiogram through the first electrode and the second electrode;
the processor is respectively and electrically connected with the impedance detection module and the electrocardiogram monitoring module and is used for judging whether the impedance value is greater than a preset impedance threshold value and judging whether normal electrocardiogram waveforms exist in the real-time electrocardiogram; when the impedance value is larger than a preset impedance threshold value and/or normal electrocardiogram waveforms do not exist in the real-time electrocardiogram, adjusting the positions of the first and second electrode; and when the impedance value is smaller than or equal to the preset impedance threshold value and normal electrocardiogram waveforms exist in the real-time electrocardiogram, controlling the first electrode and the second electrode to perform electric induction flutter.
5. The electrical defibrillation device of claim 4, wherein the first defibrillation electrode and the second defibrillation electrode are electrically connected to the impedance detection module and the ecg monitoring module through a first switch, respectively, and the processor is further configured to control the first switch to be turned on or off.
6. The electrical defibrillation device of claim 4, further comprising a power processing module electrically connected to the processor and a power source electrically connected to the power processing module, wherein the power processing module is electrically connected to the first and second electrodes.
7. The electrical flutter inducing device according to claim 6, wherein a control output module is electrically connected between the power supply processing module and the first and second flutter inducing electrodes, and the control output module is simultaneously electrically connected with the processor.
8. The electrical defibrillation apparatus according to claim 7, wherein the first and second defibrillation electrodes are electrically connected to the control output module through second switches, respectively, and the processor is further configured to control the second switches to be turned on or off.
9. The electrical shiver device of claim 4, further comprising a display interface module, a voice prompt module, a memory recording module and a key operation module electrically connected to the processor.
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