CN111643563B - Composition for harmonizing stomach, protecting liver and dispelling effects of alcohol and preparation method thereof - Google Patents
Composition for harmonizing stomach, protecting liver and dispelling effects of alcohol and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a composition for harmonizing stomach, protecting liver and alleviating hangover and a preparation method thereof, wherein kudzu root, raisin tree seed, mulberry leaf, hawthorn and dried orange peel which are commonly used for alleviating hangover are compatible, the content of raisin tree seed is greatly reduced in the formula of the composition, and the kudzu root, the dried orange peel and the mulberry are used as main components, so that the composition obtained by specific matching not only can alleviate hangover, nourish liver and protect liver, but also harmonize stomach, and the composition provided by the invention has no toxic medicaments in the formula, all the raw materials are medicinal and edible traditional Chinese medicines, and the safety is good; the raw materials of the invention do not contain precious traditional Chinese medicinal materials, the variety is simple, the market quantity is polyvalent and cheap, the invention can be prepared into the forms of tablets, capsules, solid beverages and the like, and the invention is convenient to carry and take.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine, in particular to a composition for harmonizing stomach, protecting liver and neutralizing the effect of alcoholic drinks and a preparation method thereof.
Background
The wine is a popular beverage, but no matter the wine is white wine, red wine, beer or medicinal liquor, the wine can be used for maintaining health and relaxing the emotion in a small prescription, and the liver and the stomach are damaged by luxury drinking. Alcohol is mainly absorbed through stomach and duodenum during drinking, when a person drinks a large amount of alcohol in a short time, ethanol appears in blood after 5min, the concentration of the ethanol begins to decrease after 2h, and the ethanol in the blood can be completely metabolized after 16 h. More than 90% of ethanol entering the body is metabolized in the liver, and the ethanol and metabolites thereof can generate a large amount of free radicals to damage the liver.
The Chinese herbal medicine has unique advantages in the aspect of relieving alcoholism due to the characteristics of small side effect, good prevention effect and the like. The kudzu root and the raisin tree seed are common Chinese herbal medicines with the function of relieving alcoholism, the kudzu root is the dried root of the kudzu of leguminous plant, is rich in nutrition, contains flavonoid active ingredients such as daidzin, puerarin and the like, and can effectively relieve alcoholism and protect liver; semen Hoveniae, also known as semen Hoveniae, is seed of Hovenia dulcis Thunb of Rhamnaceae, contains soap, flavone, alkaloid, etc., and has effects of relieving alcoholism and benefiting liver. But it is forbidden in cases of deficiency-cold of spleen and stomach due to Hovenia dulcis, which is recorded in De Cang Ben Cao (de-Cang herbal medicine).
In the Chinese herbal medicine anti-inebriation medicine composition on the market, or the content of hovenia dulcis thunb is higher, such as zhangwen and the like, experimental observation of anti-inebriation effect of hovenia dulcis thunb and kudzuvine root drink [ J ], Chinese Hovenia pharmaceutical journal, 1994, 14 (3): 137-137 discloses a traditional Chinese medicine compound with an anti-alcoholism effect, which is prepared from hovenia dulcis thunb, radix puerariae, medlar and hawthorn in a weight ratio of 1: 0.4, and the compound can obviously relieve drunkenness symptoms in a clinical process; or some precious or complex raw materials are added for cooperation, for example, Chinese patent application with publication number CN 111214553A discloses a composition for dispelling the effects of alcohol and nourishing the stomach, a beverage thereof and a preparation method thereof, wherein the composition mainly comprises kudzu root, hovenia dulcis thunb, Chinese olive, ginseng, dandelion, hericium erinaceus and honey in a mass ratio of 5-20: 2-10: 2-8: 1-4: 2-10: 5-14: 5-20; chinese patent with the authorization number of CN 108619484B discloses a biological protein extracted from liver-protecting and alcoholism-relieving silkworm pupas, which comprises silkworm pupa protein powder obtained by liquid nitrogen grinding, degreasing, decoloring, deodorizing and the like. Therefore, the research and development of the composition which has simple and easily obtained raw materials and can harmonize the stomach, protect the liver and relieve alcoholism has wide market prospect.
Disclosure of Invention
The invention aims to provide a composition for harmonizing the stomach, protecting the liver and neutralizing the effect of alcoholic drinks, which has simple and easily obtained raw materials, can harmonize the stomach, protect the liver and neutralize the effect of alcoholic drinks and has wide market prospect.
In order to achieve the purpose, the invention adopts the following technical scheme:
the composition for harmonizing the stomach, protecting the liver and neutralizing the effect of alcohol comprises the following preparation raw materials in parts by weight: 20 to 30 portions of kudzuvine root, 13 to 20 portions of mulberry, 10 to 15 portions of mulberry leaf, 5 to 8 portions of hovenia dulcis thunb, 10 to 15 portions of hawthorn and 20 to 30 portions of tangerine peel.
Preferably, the preparation raw materials comprise the following components in parts by weight: 20 parts of kudzuvine root, 15 parts of mulberry, 10 parts of mulberry leaf, 5 parts of hovenia dulcis thunb, 10 parts of hawthorn and 20 parts of dried orange peel.
Optionally, the composition is a solid beverage, tablet, granule or capsule.
Another object of the present invention is to provide a method for preparing the above composition, which comprises the steps of:
s1, preparing kudzu root, mulberry leaf, hovenia dulcis thumb, hawthorn and dried orange peel, cleaning, drying, and weighing according to a formula for later use;
s2, putting the weighed raw materials into an extraction tank, adding 5-10 times of water into the extraction tank, extracting for 3-5 times, and filtering to obtain a filtrate after each extraction;
s3, merging the filtrates obtained in the step S2, and concentrating the filtrates under reduced pressure to obtain an extract;
s4, drying, crushing, mixing and packaging the extract obtained in the step S3 to obtain the traditional Chinese medicine composition.
Optionally, in the step S1, the drying temperature is 60 ℃. Through cleaning, drying, preprocessing and weighing, impurities such as dirt, dust and the like on the surfaces of the traditional Chinese medicine raw materials can be better removed, and meanwhile, the influence of water in important raw materials on the ratio is avoided.
Optionally, in the step S2, the time for each water addition extraction is 1 to 3 hours.
Optionally, the relative density of the extract obtained in the step S3 is 1.10-1.25 g/mL at 60 ℃.
Optionally, the drying method in step S4 is a spray drying method or a vacuum drying method.
In the formula, the mulberry is the dry fruit cluster of the mulberry of the Moraceae family, has the effects of benefiting the joints of the five internal organs, promoting blood circulation, calming mind, reducing blood pressure, quenching thirst, relieving alcoholism in middle-jiao and the like, can supplement the deficiency of gastric juice when entering the stomach, promotes the digestion of the gastric juice, promotes the secretion of intestinal juice when entering the intestine, and promotes the gastrointestinal motility; the folium Mori is dry leaf of Morus alba L of Moraceae, and has effects of clearing lung-heat, moistening dryness, nourishing liver, removing liver fire, improving eyesight, and treating dizziness; the hawthorn is dried mature fruit of Crataegus pinnatifida bge or Crataegus pinnatifida bge of Rosaceae, has the effects of strengthening spleen, stimulating appetite, promoting digestion and resolving stagnation, is rich in various enzymes, can promote the decomposition of ethanol and accelerate the metabolism of the ethanol; the pericarpium Citri Tangerinae is dried mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar, and has effects of regulating gastrointestinal smooth muscle movement, controlling digestive juice secretion, and also has certain liver protecting effect.
After adopting the technical scheme, compared with the background technology, the invention has the following advantages:
1. according to the invention, kudzu root and raisin tree seed which are commonly used for relieving alcoholism are compatible with mulberry, mulberry leaf, hawthorn and dried orange peel, the raisin tree seed proportion in the formula of the composition is greatly reduced, and the kudzu root, the dried orange peel and the mulberry are taken as main components, so that the composition obtained by specific matching not only can relieve alcoholism, nourish liver and protect liver, but also can harmonize stomach, and has a remarkable relieving effect on uncomfortable symptoms such as nausea, vomit, stomach discomfort, unstable gait and the like of drunkenness people;
2. the raw materials of the invention do not contain valuable traditional Chinese medicinal materials, the variety is simple, the market quantity is polyvalent and cheap, and the preparation method has simple flow and convenient preparation, does not need special equipment, saves manpower and material resources and has wide market prospect;
3. the composition provided by the invention has no toxic medicine in the formula, and all the raw materials are medicinal and edible traditional Chinese medicines, so that the safety is good;
4. the invention can be prepared into tablets, capsules, solid beverages and other forms, and is convenient to carry and take.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention. The raw materials and equipment used in the present invention are commercially available unless otherwise specified. And all the raw materials meet the relevant national sanitary standards.
Example 1
A composition for harmonizing stomach, protecting liver and alleviating hangover, which can be solid beverage, tablet, granule or capsule, is prepared by the following steps:
s1, preparing kudzu vine root, mulberry leaf, hovenia dulcis thunb, hawthorn and dried orange peel, cleaning, drying at 60 ℃, and weighing according to parts by weight: 20 parts of kudzuvine root, 15 parts of mulberry, 10 parts of mulberry leaf, 5 parts of hovenia dulcis thunb, 10 parts of hawthorn and 20 parts of dried orange peel for later use;
s2, putting the weighed raw materials into an extraction tank, adding water which is 10 times of the total mass of the raw materials for extraction, extracting for 3 hours, and filtering to obtain filtrate and filter residues; then adding water which is 5-10 times of the total mass of the filter residue into the filter residue, extracting for 1-3 hours, filtering again to obtain filtrate and filter residue, and repeating the extraction for 3-5 times;
s3, merging the filtrates obtained in the step S2, and concentrating under reduced pressure to obtain an extract with the relative density of 1.10-1.25 g/mL at 60 ℃;
s4, drying the extract obtained in the step S3 by a spray drying method or a vacuum drying method, crushing, mixing and packaging.
Example 2
A composition for harmonizing stomach, protecting liver and alleviating hangover, which can be solid beverage, tablet, granule or capsule, and the preparation method thereof comprises the following steps:
s1, preparing kudzu root, mulberry leaf, hovenia dulcis thunb, hawthorn and dried orange peel, cleaning, drying at 60 ℃, and weighing according to the parts by weight: 30 parts of kudzuvine root, 20 parts of mulberry, 13 parts of mulberry leaf, 8 parts of hovenia dulcis thunb, 15 parts of hawthorn and 30 parts of dried orange peel for later use;
s2, putting the weighed raw materials into an extraction tank, adding water which is 10 times of the total mass of the raw materials for extraction, extracting for 3 hours, and filtering to obtain filtrate and filter residues; then adding water which is 5-10 times of the total mass of the filter residue into the filter residue, extracting for 1-3 hours, filtering again to obtain filtrate and filter residue, and repeating the extraction for 3-5 times;
s3, merging the filtrates obtained in the step S2, and concentrating under reduced pressure to obtain an extract with the relative density of 1.10-1.25 g/mL at 60 ℃;
s4, drying the extract obtained in the step S3 by a spray drying method or a vacuum drying method, crushing, mixing and packaging.
Example 3
A composition for harmonizing stomach, protecting liver and alleviating hangover, which can be solid beverage, tablet, granule or capsule, is prepared by the following steps:
s1, preparing kudzu vine root, mulberry leaf, hovenia dulcis thunb, hawthorn and dried orange peel, cleaning, drying at 60 ℃, and weighing according to parts by weight: 25 parts of kudzuvine root, 13 parts of mulberry, 12 parts of mulberry leaf, 6 parts of hovenia dulcis thunb, 13 parts of hawthorn and 23 parts of dried orange peel for later use;
s2, putting the weighed raw materials into an extraction tank, adding water which is 10 times of the total mass of the raw materials for extraction, extracting for 3 hours, and filtering to obtain filtrate and filter residues; then adding water which is 5-10 times of the total mass of the filter residues into the filter residues, extracting for 1-3 hours, filtering again to obtain filtrate and filter residues, and repeating the extraction for 3-5 times;
s3, merging the filtrates obtained in the step S2, and concentrating under reduced pressure to obtain an extract with the relative density of 1.10-1.25 g/mL at 60 ℃;
s4, drying the extract obtained in the step S3 by a spray drying method or a vacuum drying method, crushing, mixing and packaging.
Example 4
A composition for harmonizing stomach, protecting liver and alleviating hangover, which can be solid beverage, tablet, granule or capsule, and the preparation method thereof comprises the following steps:
s1, preparing kudzu vine root, mulberry leaf, hovenia dulcis thunb, hawthorn and dried orange peel, cleaning, drying at 60 ℃, and weighing according to parts by weight: 27 parts of kudzuvine root, 18 parts of mulberry, 14 parts of mulberry leaf, 7 parts of raisin tree seed, 13 parts of hawthorn and 27 parts of dried orange peel for later use;
s2, putting the weighed raw materials into an extraction tank, adding water which is 5-10 times of the total mass of the raw materials for extraction, extracting for 1-3 hours, and filtering to obtain filtrate and filter residues; then adding water which is 5-10 times of the total mass of the filter residue into the filter residue, extracting for 1-3 hours, filtering again to obtain filtrate and filter residue, and repeating the extraction for 3-5 times;
s3, merging the filtrates obtained in the step S2, and concentrating under reduced pressure to obtain an extract with the relative density of 1.10-1.25 g/mL at 60 ℃;
s4, drying the extract obtained in the step S3 by a spray drying method or a vacuum drying method, crushing, mixing and packaging.
Comparative example 1
The comparative example differs from example 1 in that: the starting material did not contain pueraria lobata of example 1.
Comparative example 2
This comparative example differs from example 1 in that: the raw material did not contain morous alba of example 1.
Comparative example 3
This comparative example differs from example 1 in that: the raw material did not contain mulberry leaves in example 1.
Comparative example 4
This comparative example differs from example 1 in that: the raw material does not comprise hovenia dulcis thunb in example 1.
Comparative example 5
This comparative example differs from example 1 in that: the starting material did not contain the hawthorn of example 1.
Comparative example 6
This comparative example differs from example 1 in that: the raw material does not contain the dried orange peel in example 1.
Comparative example 7
This comparative example differs from example 1 in that: the raw materials of the traditional Chinese medicine are 20 parts of hovenia dulcis thunb, which is the same as the kudzuvine root in parts by weight.
Test of
72 drinkers are selected for testing, and are divided into three groups according to the drinking condition: each group of 24 persons is divided into a test group and a control group, wherein 3 persons in the test group take the composition prepared in the example 1 after drinking wine (10 g of solid beverage is taken and taken with warm boiled water), 21 persons in the control group are divided into 7 groups which are sequentially called as the control group 1 to the control group 7, the compositions in the comparative examples 1 to 7 are correspondingly taken respectively, and the symptoms of the persons in each group are counted. The statistical results of the test are shown in table 1.
TABLE 1 solid beverage test results for harmonizing stomach, protecting liver and relieving alcoholism
As can be seen from table 1, the test group has the effects of relieving alcoholism and harmonizing stomach, the test group has the effect of relieving alcoholism equivalent to that of the control group 7, but the dosage of hovenia dulcis thunb is increased, and the restoration of appetite may have a certain influence, and the results of the test group and the control group 1-6 are compared, so that the composition obtained by specific matching of the kudzuvine root, the mulberry leaf, the hovenia dulcis thunb, the hawthorn and the dried orange peel in the example 1 can give consideration to relieving alcoholism, nourishing liver, protecting liver and nourishing stomach, and the effect is obviously reduced if one component is lacked.
In addition, the composition provided by the invention has no toxic medicine in the formula, and all raw materials are medicinal and edible traditional Chinese medicines, so that the safety is good; the raw materials of the invention do not contain valuable traditional Chinese medicinal materials, the variety is simple, the market quantity is polyvalent and cheap, and the preparation method has simple flow, convenient preparation, no need of special equipment, manpower and material resources conservation and wide market prospect.
Although the present invention is disclosed above, the present invention is not limited thereto. Various changes and modifications may be effected therein by one skilled in the art without departing from the spirit and scope of the invention as defined in the appended claims.
Claims (7)
1. A composition for harmonizing stomach, protecting liver and neutralizing the effect of alcohol is characterized in that: the preparation raw materials comprise the following substances in parts by weight: 20-30 parts of kudzu root, 13-20 parts of mulberry, 10-15 parts of mulberry leaf, 5-8 parts of raisin tree seed, 10-15 parts of hawthorn and 20-30 parts of dried orange peel;
the preparation method of the composition comprises the following steps:
s1, preparing kudzu root, mulberry leaf, hovenia dulcis thumb, hawthorn and dried orange peel, cleaning, drying, and weighing according to a formula for later use;
s2, putting the weighed raw materials into an extraction tank, adding 5-10 times of water into the extraction tank, extracting for 3-5 times, and filtering to obtain a filtrate after each extraction;
s3, merging the filtrates obtained in the step S2, and concentrating the filtrates under reduced pressure to obtain an extract;
s4, drying, crushing, mixing and packaging the extract obtained in the step S3 to obtain the traditional Chinese medicine composition.
2. The composition for harmonizing the stomach, protecting the liver and neutralizing the effect of alcoholic drinks according to claim 1, which is characterized in that: the preparation raw materials comprise the following substances in parts by weight: 20 parts of kudzuvine root, 15 parts of mulberry, 10 parts of mulberry leaf, 5 parts of raisin tree seed, 10 parts of hawthorn and 20 parts of dried orange peel.
3. The composition for harmonizing the stomach, protecting the liver and neutralizing the effect of alcoholic drinks according to claim 1, which is characterized in that: the composition is in the form of solid beverage, tablet, granule or capsule.
4. A composition for harmonizing the stomach, protecting the liver and neutralizing the effect of alcohol according to any one of claims 1 to 3, which is characterized in that: in the step S1, the drying temperature is 60 ℃.
5. A composition for harmonizing the stomach, protecting the liver and neutralizing the effect of alcohol according to any one of claims 1 to 3, which is characterized in that: in the step S2, the time for each water adding extraction is 1-3 hours.
6. A composition for harmonizing the stomach, protecting the liver and neutralizing the effect of alcohol according to any one of claims 1 to 3, which is characterized in that: the relative density of the extract obtained in the step S3 is 1.10-1.25 g/mL at 60 ℃.
7. A composition for harmonizing the stomach, protecting the liver and neutralizing the effect of alcohol according to any one of claims 1 to 3, which is characterized in that: the drying method in the step S4 is a spray drying method or a vacuum drying method.
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| CN101791380A (en) * | 2010-03-17 | 2010-08-04 | 赤峰丹龙药业有限公司 | Health product for sobering up and relieving alcohol |
| CN102366604A (en) * | 2011-06-28 | 2012-03-07 | 赵金娥 | Sobering traditional Chinese medicinal preparation and its preparation method |
| CN103385510B (en) * | 2013-08-05 | 2015-11-18 | 江苏茅宝葛业有限公司 | A kind of preparation method of root of kudzu vine mulberry compound hangover-alleviatingsoybean beverage |
| CN105533380B (en) * | 2015-12-04 | 2018-08-03 | 广东橘香斋陈皮有限公司 | A kind of Dealcoholic solid beverage and preparation method thereof |
| CN109432387A (en) * | 2018-12-21 | 2019-03-08 | 陕西师范大学 | It is a kind of with the Chinese medicine-peptide combinations and preparation method thereof for resisting drunk effect |
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2020
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