CN1115109C - Multipotential intestinal nutrient and its production method - Google Patents

Abstract

An all-purpose enteral nutrient, which is made from natural foods such as hydrolyzed protein, rice, millet, and vegetables. The rice and millet are powdered, and the vegetables are extracted and mixed. Reasonable nutrition, suitable for long-term use by diabetics and patients with mild renal insufficiency.

Description

A kind of multipotential intestinal nutrient and production method thereof

The present invention relates to a kind of food and production method thereof, particularly a kind of multipotential intestinal nutrient and production method thereof.

For many years, in clinical EA treatment, for the normal person of gastrointestinal function, first-selected homogenate meals, because of its composition near normal person's dietary structure, derive from natural food, collocation rationally, infiltration forces down, long-term use can be kept the normal function and the institutional framework of glandula digestive, is a kind of inexpensive, EA supporting agent that side effect is little, effective.At present, part hospital still adopts by doctor or nutrition doctor and leaves prescription, and the kitchen modulates to patient by the dining room.Because this modulation working link is many, and the non-again nutrition professional of dining room staff, thereby be subject to main, objective factor influence, cause the composition instability, health be cannot say for sure to influence result of use by card.

In recent years, existing producer begins to produce nutrient, and these products mainly are the extracts with food or food, makes the material that does not need or not exclusively need human body startup digestive function just can directly absorb; This nutrient is suitable for digesting Insufficient patient; But for the normal or basic normal patient of digestive function, the long-term use then causes the degeneration of its digestive function, and be unhelpful to patient on the contrary.Chinese patent application 99124658.6 discloses a kind of multipotential nutrition element and production method thereof that is applicable to the tube feed patient, this nutrient lacks cellulose, contain monose or compound sugar, nutrition content is indeterminate, exist long-term use and easily cause constipation, it is indeterminate to be suitable for patient's kind, is not suitable for diabetes patient, critically ill patient, and slight renal insufficiency person such as can not use for a long time at shortcoming.

Purpose of the present invention is exactly for overcoming the above-mentioned shortcoming of present enteral nutrients, provide that a kind of nutrition is constant, product health, nutrition rationally, infiltration forces down, is applicable to the long-term enteral nutrients and the production method of using thereof of patient of diabetes patient, slight renal insufficiency and hyperlipidemia.

The present invention realizes like this.

The present invention adopts the prescription (unit: gram) of following weight ratio

Rice 200～340 cow's milk 230～280

Millet 0～100 dried lotus seeds 0～26

Green vegetables 100～800 black fungus 0～10

Carrot 140～170 sesame oil 20～32

Soya bean 20～30 salt 6～9

Egg 10～30 protein hydrolysate 15～23

Cellulose 14～17 vitamins are by the reference of Chinese residents diet nutritional

Trace element intake adds

Altogether processing is into about 420～470 gram pulvis, faces the time spent to be made into homogenate.

The weight sum that requires rice and millet simultaneously is between 300～360 grams, and the amount of rice, millet also can adopt 3/4 times dextrin of its weight or starch to replace.

Because flour toughness is too big, be not suitable for making the homogenate tube feed and use, and processing is difficult for.

Green vegetables of the present invention can adopt various green vegetables, as rape, pakchoi, romaine lettuce, cabbage heart etc.Also can adopt the corresponding dry vegetalbe that plants vegetables, this moment is by the weight of the corresponding reduction dish of the moisture that it reduced.

Dietary function is mainly considered in the increase of dried lotus seeds, black fungus, can add, also can not add.Lotus seeds as not adding lotus seeds, can increase the weight of rice or millet or dextrin or starch owing to contain a certain amount of carbohydrate in right amount.

Sesame oil can replace with the vegetable oil of other type, as peanut oil, rapeseed oil, safflower wet goods.Poultry meat and dried meat floss generally do not adopt owing to contain animal tallow and be difficult to control the content of albumen.

Vitamin and trace element press RNIs and are added, and its consumption restrains finished products (promptly intake) for each person every day by per 450:

The final content of title additive capacity

Cobastab ₁(mg) 0.3～0.5 1.1～1.3

Cobastab ₂(mg) 0.6～0.9 1.4～1.6

Nicotinic acid (mg) 8～10 15～18

Vitamin C (mg) 50～70 62～85

Potassium (mg) 200～300 2000～2400

Calcium (mg) 150～250 850～1000

Zinc (mg) 5～10 15～20

Selenium (g) 5～12 50～60

Wherein protein hydrolysate is the flesh of fish/or the mixture of arbitrary proportion of poultry and/or poultry meat, and hydrolysis forms according to a conventional method.

Its production method is:

1, rice, millet oven dry are beaten powder and are sieved, and get standby powder 1..

2, egg and cow's milk stirring and emulsifying mixing, 2. spray-drying gets standby powder.

3, dried green vegetables, carrot, soya bean, dried lotus seeds, black fungus cold water soak one day, water

Carry 1-3 time, mixed liquor is concentrated into certain proportion, with the salt dissolving wherein, and spray-drying

Get standby powder 3..

4, with standby powder 1., 2., 3., protein hydrolysate, cellulose is with the abundant mixing of mixer, adds sesame oil again and mixes, and puts oven drying, sieves, and adds vitamin, trace element stirs, packing is promptly.

The present invention is a fresh vegetables as the green vegetables that adopt, and soaking-free directly water is carried.

Eating method of the present invention is

1. get to stir in this product 1 pouch (75g) adding 250ml boiling water and make 300ml liquid meals (also can boil), direct tube feed or oral, every milliliter provides 1,000 kilocalories of heats;

2. temporarily without the person, add a cover and put into refrigerator after preparing, low temperature is preserved in 24 hours and is used up;

3. non-special circumstances need not to increase other food.

Enteral nutrients of the present invention is applicable to that the normal or basic normal patient of gastrointestinal function uses, and comprising:

1, mouth, pharynx, esophagus disease etc. can not the oral feeding persons;

2, cerebrovas-cularaccident, stupor, ICT and pharyngeal reflex forfeiture, the patient that can not swallow;

3, high-energy wasting disease people such as peri-operation period, burn, wound;

4, the underfed nutritional supplementation due to tumor radiotherapy, chemotherapy patients and the various diseases;

5, the ordinary people is direct-edible as food.

Enteral nutrients of the present invention has that nutrition is constant, product health, nutrition advantage of reasonable, diabetes patient's hyperlipidemia, slight renal insufficiency person can use for a long time, its application has made things convenient for some can not be taken food, rely on for a long time the patient of hospital by mouth, patient has had a kind of nutrient that can substitute food fully, be in and take after mixing it with water voluntarily, reduce hospitalization cost, improved hospital's bed rotation rate.Show that through observation of curative effect patient uses through long-term, albumin and lymphocyte number rise, and triglycerides, cholesterol and blood glucose value reduce, and immunocompetence improves, and can effectively prevent constipation, and the effect that reduces triglycerides and cholesterol is arranged.

The following example only is used to illustrate the present invention, and protection scope of the present invention is not had any restriction.

Embodiment 1

Prescription unit: gram

Rice 220 cow's milk 250

Millet 100 dried lotus seeds 25

Cabbage heart 300 black fungus 2

Carrot 150 sesame oil 24

Soya bean 25 salt 8

Egg 25 protein hydrolysate 15

Cellulose 15 vitamins, dimension secondary element add

Through calculating, the content of each main nutrition is:

Protein 67g～69g accounts for 14.8%～15.3%

Fat 44g～47g accounts for 22.0%～23.5%

Carbohydrate 275g～286g accounts for 59.2%～63.5%

Total amount of heat 1800～1860Kcal/ bag

Adopt aforementioned production method, finally be distributed into every pouch 75 grams, 6 pouches are 1 bag, and the one day consumption of being grown up is 1 bag.Wherein protein hydrolysate adopts the protein hydrolysate of the arbitrary proportion of the flesh of fish, chicken, pork, beef.

Embodiment 2

Prescription unit: gram

Rice 200 cow's milk 230

Millet 120 dried lotus seeds 26

Pakchoi 800 black fungus 0

Carrot 170 peanut oil 20

Analysis for soybean powder 29 salt 6

Egg 10 protein hydrolysate 17

Cellulose 14 vitamins are by the Chinese residents diet nutritional

Trace element adds with reference to intake

Protein hydrolysate adopts flesh of fish protein hydrolysate, and production method is the same, is processed into pulvis

Embodiment 3

Prescription unit: gram

Rice 340 cow's milk 280

Millet 0 dried lotus seeds 0

Rape 100 black fungus 10

Carrot 140 sesame oil 32

Analysis for soybean powder 30 salt 9

Egg 30 protein hydrolysate 23

Cellulose 17 vitamins are by the Chinese residents diet nutritional

Trace element adds with reference to intake

Protein hydrolysate adopts pork protein hydrolysate, and production method is the same, is processed into pulvis.

Embodiment 4 units: gram

Prescription

Rice 100 carrots 150

Millet 180 pakchois 200

Egg 25 dried lotus seeds 25

Cow's milk 250 salt 8

Soya bean 25 protein hydrolysate 22

Dextrin 80 vitamins are by the Chinese residents diet nutritional

Trace element adds with reference to intake

Make pulvis as stated above

Embodiment 5, the evaluation of nutrition of prolonged application embodiment 1

Edible embodiment 1 patient of nutrient more than 1 year be totally 24 examples, uses laggard field headquarters and support evaluation, and be respond well.

Materials and methods:

One, research object

1, physical data, sex: male 22 examples, women 2 examples; Age: 68～89 years old, average 76 ± 8.2 years old.

2, the disease that takes a disease: sequelae for cerebral infraction 12 examples: Parkinson's disease 7 examples; Senile dementia 3 examples; Chronic adrenocortical insufficiency 1 example; Coronary heart disease 1 example all can not oral feeding, 13 routine complication with diabetes wherein, and 11 examples merge the infection at positions such as lung, urinary system during this period.

Two, experimental design:

1, heat is supplied with: all patients all give nutrient homogenate meals of the present invention under the gastrointestinal function permission.Do not suffer from diabetes, heat provided by 25～30Kcal/kg/ day, and diabetic then individuation calculates separately, and multiply by when concurrent infection and other diseases accordingly stress coefficient.

2, give method and approach: 6 mean allocation of total amount of heat every day, Nasal gastrointestinal tube slowly injects.

3, each patient chooses beginning 1 year behind the tube feed, record start index, 1 index of later per 4 months records.

Three, detect index:

1, anthropological measuring: comprise that body index, triceps skinfold thickness, arm flesh enclose.

2, laboratory examination; Total protein, albumin, T-CHOL, triglycerides, blood sugar, phosphorus, lymphocyte number, hemoglobin.

Four, statistical procedures:

The result is expressed as mean ± standard deviation, and (X ± S), relatively, there was conspicuousness P＜0.05 for difference when the utilization paired t-test began with observation respectively.The result:

One, anthropological measuring result: (seeing Table 1)

Laboratory examination result: (seeing Table 2)

Table 1 anthropometric data (X ± S)

Measure the numerical measuring index

Begin 4 months 8 months 12 constitutional index 20.1 ± 2.6 20.7 ± 1.5 21.2 ± 1.8 20.8 ± 2.9

(kg/m ²) triceps skinfold thickness 9.3 ± 4.2 8.9 ± 5.3 9.4 ± 3.7 9.4 ± 4.9

(mm) arm flesh encloses (cm) 24.8 ± 3.4 25.4 ± 2.7 25.6 ± 4.2 24.5 ± 3.9

Table 2 laboratory examination result

The check result inspection item

Begin 4 months 8 months 12 months total protein (g/L) 64.19 ± 7.96 65.38 ± 4.72 64.51 ± 6.64 66.57 ± 8.48 albumin (g/L) 36.4 ± 4.03 36.60 ± 4.42 38.20 ± 3.77*, 40.40 ± 3.33** T-CHOLs (mmol/L) 4.39 ± 1.33 4.24 ± 1.36 4.50 ± 1.28 4.29 ± 1.05 triglycerides (mmol/L) 1.47 ± 0.97 1.28 ± 0.68 1.22 ± 0.84 1.13 ± 0.76 phosphorus (mmol/L) 1.10 ± 0.19 1.08 ± 0.32 1.06 ± 0.12 1.15 ± 0.31* blood sugar (mmol/L), 7.80 ± 5.10 6.67 ± 3.59*, 6.16 ± 2.66*, 5.22 ± 1.22** magnesium (mol/L) 1.01 ± 0.25 0.94 ± 0.12 0.94 ± 0.09 0.97 ± 0.13 lymphocytes (10⁹/ L) 1.99 ± 0.61 2.32 ± 0.24 2.26 ± 0.73 2.54 ± 1.44 ^*Hemoglobin (g/L) 133.2 ± 19.80 121.4 ± 19.12 124.1 ± 22.31 126.9 ± 20.07 is annotated: behind nasal feeding embodiment 1 nutrient significant difference is arranged ^*P＜0.05, ^*P＜0.01.

Through 636 patient's Application Examples 1, bad reactions such as no abdominal distension, stomachache, diarrhoea, nutritional status is satisfied.Tracing observation uses patient's 24 examples more than 1 year, and anthropological measuring achievement data and experimental check show that triceps skinfold thickness is normal, and albumin and lymphocyte number rise, and blood glucose value reduces, and learning by statistics to handle has significant difference.Simultaneously, triglycerides and cholesterol value also exist the tendency of reduction.

The result shows:

1, patient all keeps or has strengthened nutrition condition, and immunocompetence improves.

2, product meets diabetic diet composition constituent ratio and does not contain monose, can reduce blood glucose value under the prerequisite of control heat energy, and the patient under diabetic and the stress situation can use.

3, fibre-bearing element of the present invention can effectively prevent constipation, and the effect that reduces triglycerides and cholesterol is arranged.

Embodiments of the invention 2, embodiment 3 have very close effect with embodiment 1.

Along with the aging trend of the whole society, because the oral feeding voluntarily that a variety of causes causes, essential gerontal patient through Nasal gastrointestinal tube supply nutrition is more and more.The effect of homogenate meals is outstanding day by day, and how fair supply nutrition cooperates clinical treatment, reaches and builds up resistance, and prolongs the purpose of life, has become its mission.

Our development and the finished product homogenate meals nutrient of using have changed that self-control homogenate meals composition is non-constant, health be cannot say for sure the problem demonstrate,proved.Its every vitamin and micronutrient levels meet or exceed the acceptable daily intake standard respectively, and the reasonable mixture ratio of three big nutrients is not additionally added single, double sugar.The protein provision abundance, based on the animal protein of high biological value, necessary amino acid is complete, can effectively keep positive nitrogen equilibrium, and the albumin value is improved, and total protein and hemoglobin value remain in the normal range (NR).Reduce fat relatively and supply with, emphasize unsaturated fat, blood triglyceride and cholesterol in viewing duration, do not occur and raise.The elderly descends to the metabolic rate of carbohydrate, requires the corresponding decline of intake, and this ratio not only is fit to common patient, also meets the diet composition composition of diabetes, under the prerequisite of control total amount of heat, has significantly reduced blood glucose value.Cellulosic absorption helps promoting or stimulating intestines peristalsis, and detoxifcation and suction-operated is arranged, reduction cholesterol effect etc., by fiber content of the present invention, patient does not see bad reactions such as relevant diarrhoea, abdominal distension, calcium, phosphorus shortage, and on the contrary, phosphorus content significantly raises on the contrary.

When gastrointestinal function allows, should at first consider enteral nutrition, for the normal patient of digestive function, answer first-selected homogenate meals, because of its meals content near normal person's dietary structure, derive from natural food, nutrition arrangement is reasonable, osmotic pressure is lower, and long-term use can be kept the normal function and the institutional framework of glandula digestive.In the viewing duration in 1 year, protein one caloric malnutrition does not appear among the patient.From the anthropological measuring index, triceps skinfold thickness is normal, arm flesh encloses lower slightly, illustrate the body fat situation still can, muscle deposit is less, and the front and back there was no significant difference, the latter and the elderly's anabolism reduce, the characteristics that catabolism increases are relevant, also with bed, the rare pass of activity, are difficult to the people for a change.Albumin and lymphocyte number rise, and illustrate that nutrition condition and immunocompetence have raising.

By the observation in 1 year, the patient all kept or has strengthened nutrition condition, no related complication and bad reaction.And diabetes there is certain dietary therapy effect, and reduces the effect of triglycerides and cholesterol.

Claims (6)

1, a kind of omnipotent enteral nutrient, is characterized in that adopting following weight ratio to make powder: Rice 220-340 grams Milk 230-280 grams Millet 0～100g Dried lotus seeds 0～26g Green vegetables 100-800 grams Black fungus 0-10 grams Carrot 140-170 grams Sesame oil 20-32 grams Soybeans 20-30 grams Salt 6-9 grams Eggs 10-30 grams Hydrolyzed protein 15-23 grams Cellulose 14~17g Add vitamin cord Addition of trace elements Among them, the sum of the weight of rice and millet is 300-360 grams, which is processed into 420-470 grams of powder in total. The added amount of vitamins and trace elements is: Vitamin _B1 (mg) 0.3～0.5 Vitamin _B2 (mg) 0.6～0.9 Vitamin PP(mg) 8～10 Vitamin C(mg) 50～70 Potassium (mg) 200～300 Calcium (mg) 150～250 Zinc (mg) 5～10 Selenium (μg) 5～12 2. The all-purpose enteral nutrient according to claim 1, characterized in that the hydrolyzed protein is the protein obtained by hydrolyzing the mixture of any proportion of fish meat and/or poultry meat and/or livestock meat. 3. The all-purpose enteral nutrient according to claim 1, characterized in that rice and millet are replaced by 3/4 times their weight of dextrin or starch. 4. The all-purpose enteral nutrient according to claim 1, characterized in that the sesame oil is replaced by peanut oil, rapeseed oil or safflower oil. 5. A method for producing an all-purpose enteral nutrient as claimed in claim 1, characterized in that the following steps are adopted: (1) Dried rice and millet powder are sieved to obtain spare powder ①; (2) Eggs and milk are stirred, emulsified and evenly mixed, and spray-dried to obtain a spare powder ②; (3) Soak dried vegetables, carrots, soybeans, dried lotus seeds, and black fungus in cold water for one day, extract with water for 1-3 times, concentrate the mixture to a certain proportion, add salt to dissolve it, and spray dry to obtain a spare powder③; (4) Fully mix the spare powder ①, ②, ③, hydrolyzed protein, and cellulose with a mixer, add sesame oil, mix evenly, dry in an oven, sieve, add vitamins and trace elements, stir, and pack. 6. The production method of the omnipotent enteral nutrient according to claim 4, characterized in that the green vegetables are directly extracted with water when fresh vegetables are used.