CN111345299A

CN111345299A - Composition and application thereof

Info

Publication number: CN111345299A
Application number: CN201811584950.8A
Authority: CN
Inventors: 黄珊珊
Original assignee: Shanghai Bijiasheng Technology Co ltd
Current assignee: Shanghai Bijiasheng Technology Co ltd
Priority date: 2018-12-24
Filing date: 2018-12-24
Publication date: 2020-06-30

Abstract

The invention discloses a composition, which comprises citral, citronellol, citronellal and vanillin; wherein the mass ratio of the citronellol to the citronellal to the citral is (2-10): 1. The composition is compounded by citral, citronellol, citronellal and vanillin, so that the insect-repelling effect is excellent, and the average effective insect-repelling time is longer than 6 h; the composition of the invention adopts natural components, avoids the harm of chemical synthetic components to human body, and is safer to use.

Description

Composition and application thereof

Technical Field

The invention relates to the technical field of mosquito repelling and killing, in particular to a composition and application thereof in repelling and killing insects.

Background

Mosquito bites are not only a nuisance, but can even seriously harm human health, such as the transmission of dysentery, dengue fever, yellow fever, lyme disease, Zika virus or West Nile virus caused by mosquito bites.

The active ingredient in most commercial insect repellents (insecticides) is DEET (mosquito repellant amine, N-diethyl-3-methylbenzamide), which can cope with a variety of mosquito bites, but DEET has the following disadvantages: 1) DEET is easy to be absorbed by human skin, and has health risk; 2) DEET produces an unpleasant odor; 3) when DEET is applied to the skin, stinging is felt.

Disclosure of Invention

In order to solve the problems that the existing insect repellents all use DEET as an active ingredient, the DEET is easy to be absorbed by skin and has health risks, and the DEET is stabbing and painful when being applied to the skin, the invention aims to provide a composition which adopts natural ingredients, has good insect repellent effect and small irritation; therefore, the invention also provides the application of the composition in preparing insect repellents and insecticides.

In order to achieve the purpose, the invention adopts the following technical scheme:

in a first aspect of the invention, there is provided a composition comprising citral, citronellol, citronellal, and vanillin; wherein the mass ratio of the citronellol to the citronellal to the citral is (2-10): 1.

Citral is naturally present in lemongrass oil, lemon oil, lime oil, citrus oil, litsea cubeba oil, and verbena oil.

The citronellol is derived from leaf of Murraya koenigii of Rutaceae, whole plant of Dracocephalum moldavica of Labiatae, Narcissus tazetta of Amaryllidaceae, strobilus Juniperi of Cupressaceae, fresh flower of Rosa rugosa of Rosaceae, leaf of Eucalyptus citriodora of Myrtaceae, and seed of Daucus carota of Umbelliferae.

Vanillin is present in beet, vanilla bean, benzoin gum, Peru balsam, Tuolu balsam.

Citronellal, found in citronella oil or eucalyptus oil.

The citral, citronellol, citronellal and vanillin are all natural ingredients, are mild and have little irritation, and are safer to use compared with chemically synthesized ingredients.

Wherein the mass ratio of vanillin, citronellol and citronellal in the composition is 1 (1-5) to 1-5.

Preferably, the composition consists of citral, citronellol, vanillin, mineral oil, ethanol, dipropylene glycol, isocyanate and an acetate-based fragrance, wherein the amount of each of citronellol and citronellol is less than 20 wt.%, the amount of the acetate-based fragrance is less than 20 wt.%, the amount of mineral oil is less than 20 wt.%, the amount of vanillin is less than 15 wt.%, and the total amount of citral, citronellol and citronellal is 5 wt.% to 50 wt.%.

Wherein, the isocyanate is selected from lauryl sulfate and sodium cocoyl sulfate, and the acetate perfume is selected from linalyl acetate or benzyl acetate.

Preferably, the composition further comprises a fragrance, a solvent, a diluent and a fixative.

Wherein, the aromatic is selected from linalyl acetate or benzyl acetate.

Wherein, the solvent is mineral oil.

Wherein, the diluent is selected from any one of water, acetone and ethanol.

Wherein, the fixing agent is sodium cocoanut alcohol sulfate.

The compositions of the present invention may be formulated as a lotion, fluid cream, gel, aerosol or spray.

The composition of the present invention, is primarily applied to topical skin to protect exposed skin from being bitten by mosquitoes. In use, a small quantity of the composition, for example 0.1 to 5 ml, is applied to the exposed area of skin from a suitable container or applicator and, if desired, is then spread over the skin using the hands or fingers or a suitable device.

In a second aspect of the invention, there is provided the use of a composition as described above in the preparation of an insect repellent or insecticide.

Compared with the prior art, the invention has the following beneficial effects: the composition is compounded by citral, citronellol, citronellal and vanillin, so that the insect-repelling effect is excellent, and the average effective insect-repelling time is longer than 6 h; the composition of the invention adopts natural components, avoids the harm of chemical synthetic components to human body, and is safer to use.

Detailed Description

The following description of the embodiments of the present invention is provided for illustrative purposes, and other advantages and effects of the present invention will become apparent to those skilled in the art from the present disclosure.

The compositions of the present invention include citral, citronellol, citronellal, and vanillin; wherein the mass ratio of the citronellol, the citronellal and the citral is (2-10):1, and the mass ratio of the vanillin, the citronellol and the citronellal is 1: (1-5): 1-5.

Citronellal, found in citronella oil or eucalyptus oil.

The citral, citronellal, citronellol and vanillin are prepared from natural components, and can be sprayed or coated on the skin surface, with low irritation to skin and no harm to body.

Example 1

Demonstration of the insect repellent effect of the composition of the present invention, various insect repellents were prepared according to the formulations given in table 1.

TABLE 1

Test method

1) Test subjects: aedes albopictus (Aedes albopictus), eclosion of 3-5 days of uninoculated female adult mosquitoes;

2) the test method comprises the following steps: according to GB/T13917.9-2009.

5 mosquito cages with the length, width and height of 40 cm × 30 cm × 30 cm are designed, at least 300 test insects are placed in each mosquito cage, 20 testers are randomly selected, 4 testers are respectively placed in each mosquito cage, and half of the testes and women are respectively placed in the mosquito cages, when the test is carried out, the left hand is used for comparison, the right hand is used for testing, the to-be-tested sample is coated on the area of 5 cm × 5 cm behind the hand of the tester, and the coating dose is 1.5mg/cm²The method comprises the steps of strictly shielding hands during testing, exposing the area of the medicine coating part of 4 cm × 4 cm, and counting the number of insects to be tested which are stopped within 2 min.

3) Investigation time and number of times

The test was started 2h after application, and then 1 time at 1h intervals until repellency failure.

4) Survey methods and content

The hands are inserted into the mosquito cage, and the mosquito stopping and falling conditions are observed by a visual inspection method.

5) Drug effect calculation method

The effective protection times of 4 subjects were added and the average was taken as the effective protection time (h) of the agent.

The results of 2min number of stops for each subject are shown in table 2.

TABLE 2

From table 2, it can be seen that when any three of citral, citronellol, citronellal, and vanillin are compounded, mosquito and insect stoppages are present on the right hand of the subject, wherein when the citral, citronellal, and citronellol are compounded, mosquito and insect stoppages are present after the subject is coated with the medicine for 5 hours; when the citronellal, the citronellol and the vanillin are compounded, the mosquito drops after the tested person applies the medicine for 3 hours; when the citral, the citronellal and the vanillin are compounded, the mosquito drops after the tested person applies the medicine for 2 hours; when the citral, the citronellol and the vanillin are compounded, the mosquito drops after the tested person applies the medicine for 2 hours; when the citral, the citronellol, the citronellal and the vanillin are compounded, the number of times of stopping falling of a subject for 2min after the patient is coated with the medicine for 6h is still 0, and the synergistic compounding effect of the citral, the citronellol, the citronellal and the vanillin is reflected.

Example 2

Various insect repellents were prepared according to the formulations in table 3, and the repellent effects of the different insect repellents were examined.

TABLE 3

The insect-repellent effects of the respective insect repellents are shown in table 4.

TABLE 4

As shown in Table 4, the composition of the present invention was changed in the ratio of the components, and the insect-repellent effect of the obtained insect-repellent was not affected.

Example 3

Application No. CN108477243A discloses "an insect repellent, insecticide composition", and specifically discloses an insect repellent, insecticide composition comprising lemongrass oil, p-menthane-3, 8-diol and vanillin, which are different in insect repellent effect compared to the composition of the present invention, the formulation of each component being as shown in table 5.

TABLE 5

The insect repellent results of the insect repellent experiments carried out on application No. CN108477243A and the composition of the present invention are shown in Table 6.

TABLE 6

Observation time (h)	Application number CN108477243A (Right-hand)	The composition of the invention (Right hand)
			2	0	0
3	0	0
			4	0	0
5	＞1	0
			6		0

As shown in table 4, the composition of the present invention exhibited more excellent insect repellent effect than application No. CN 108477243A.

The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.

Claims

1. A composition comprising citral, citronellol, citronellal, and vanillin; wherein the mass ratio of the citronellol to the citronellal to the citral is (2-10): 1.

2. The composition of claim 1, wherein the mass ratio of vanillin, citronellol, citronellal in the composition is 1 (1-5) to (1-5).

3. The composition of claim 1, wherein the composition is comprised of citral, citronellal, citronellol, vanillin, mineral oil, ethanol, dipropylene glycol, isocyanate, and an acetate-based flavorant, wherein each of citronellol and citronellal is present in an amount of less than 20 wt.%, wherein the acetate-based flavorant is present in an amount of less than 20 wt.%, wherein the mineral oil is present in an amount of less than 20 wt.%, wherein the vanillin is present in an amount of less than 15 wt.%, and wherein the total amount of citral, citronellol, and citronellal is present in an amount of from 5 wt.% to 50 wt.%.

4. A composition according to claim 3, wherein the isocyanate is selected from lauryl sulphate or sodium cocosulphate and the acetate-based fragrance is selected from linalyl acetate or benzyl acetate.

5. The composition of claim 1, wherein the composition further comprises a fragrance, a solvent, a diluent, and a fixative.

6. The composition of claim 5, wherein the fragrance is selected from the group consisting of linalyl acetate and benzyl acetate.

7. The composition of claim 5, wherein the solvent is mineral oil.

8. The composition of claim 5, wherein the diluent is selected from any one of water, acetone, and ethanol.

9. The composition of claim 5, wherein said fixative is sodium coco sulfate.

10. Use of a composition according to any one of claims 1 to 9 for the preparation of an insect repellent, insecticide.