CN111773140B - Plant essential oil composition and application thereof - Google Patents
Plant essential oil composition and application thereof Download PDFInfo
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/046—Aerosols; Foams
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/04—Antipruritics
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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Abstract
The invention discloses a plant essential oil composition and application thereof, and relates to the field of mosquito repelling. The plant essential oil composition disclosed by the invention comprises 10-30 parts of seed oil of bitter oil trees, 15-40 parts of eucalyptus citriodora leaf oil, 5-25 parts of thyme essential oil, 10-30 parts of achillea essential oil and 10-30 parts of geranium essential oil. The plant essential oil composition is natural and non-irritant, can effectively repel the mosquito-repellent incense and the mites when being applied to spray, has a good bacteriostatic and itching-relieving effect, is safe and non-irritant to the skin, and has good temperature resistance.
Description
Technical Field
The invention relates to the field of mosquito repelling, and in particular relates to a plant essential oil composition and application thereof.
Background
Mosquitoes spread diseases by means of biting, the stimulation of the mosquitoes to the human bites causes people to feel itching, and the mosquitoes can cause infection after being scratched by swelling and envelope to generate dermatitis or abscess. The chemically synthesized insecticide is a mosquito-repelling and insect-expelling product which is most widely applied, but the long-term use of the insecticide can generate toxic and side effects on a human body and cause environmental pollution, especially for infants. The plants and the extracts adopted by human beings to repel the harmful insects have been in the past millennium history, and compared with chemical insecticides, the plant essential oil has the characteristics of repelling mosquitoes, paralyzing mosquito nerves by some special components rather than directly killing the mosquitoes, so the plant essential oil has good advantages in the aspect of safety. The biting of mosquitoes on the skin of a human body is often accompanied by bacterial infection of the skin, and many plant extracts have better performance, but the plant extracts such as camphor extract are not recommended to be used in infant products, and most plant extracts only have mosquito repellent effect and have poor effect on other insects.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides the plant essential oil composition which has no stimulation to skin and has the effects of repelling mosquitoes, removing mites, inhibiting bacteria, resisting inflammation and relieving itching and the application thereof.
In order to achieve the purpose, the technical scheme adopted by the invention is as follows: a plant essential oil composition comprises seed oil of Melaleuca Alternifolia, Eucalyptus citriodora, thyme essential oil, Achillea millefolium and Pelargonium essential oil.
The oil of the tree balsam is rich in about 62% unsaturated fatty acids and up to 3% unsaponifiables, including limonoids and triterpenes, and has been used by indians to combat mosquitoes in forests and to relieve pain and inflammation. The eucalyptus citriodora leaf oil is derived from myrtaceae, eucalyptus citriodora trees, the oil content of branches and leaves is 0.8%, most of the oil is citral, and a small amount of vinegar and alcohols are also contained. Thyme essential oil thyme plant contains volatile oil, flavone, polysaccharide, triterpenes and other chemical active matter, and has the pharmacological functions of resisting bacteria, diminishing inflammation, resisting tumor, repelling mosquito, etc. the thyme essential oil has hot and warm fragrance and powerful penetrating power. The essential oil is rich in antiviral and antibacterial components, and can be used for preventing common cold, relieving muscle pain, resisting inflammation, and treating traumatic rhagadia caused by inflammation. The geranium essential oil contains linalool, citronellol, menthone, limonene and other active ingredients, and has good antibacterial and mosquito repellent effects.
Unilateral essential oil is more limited to the repellent effect of mosquito, adopts compound essential oil can play synergistic effect, increases mosquito repellent, antibacterial effect and can play the effect of relieving itching and relieving simultaneously.
Preferably, the plant essential oil composition comprises the following components in parts by weight: 10-30 parts of balsam seed oil, 15-40 parts of lemon eucalyptus oil, 5-25 parts of thyme essential oil, 10-30 parts of milfoil essential oil and 10-30 parts of geranium essential oil. The inventor discovers through a large amount of creative exploration that the compounding of the essential oil can achieve a better synergistic effect, increase mosquito repelling and bacteriostatic effects and simultaneously play a role in relieving itching and soothing.
Preferably, the plant essential oil composition comprises the following components in parts by weight: 20 parts of balsam seed oil, 25 parts of lemon eucalyptus oil, 15 parts of thyme essential oil, 20 parts of milfoil essential oil and 20 parts of geranium essential oil. The inventor discovers through a large amount of creative exploration that the compounding of the essential oil can achieve a better synergistic effect, increase mosquito repelling and bacteriostatic effects and simultaneously play a role in relieving itching and soothing.
Further, the present invention discloses a spray comprising the plant essential oil composition.
Preferably, the spray further comprises ethanol, a solubilizer, a film-forming agent and a preservative.
Preferably, the mass ratio of the ethanol to the plant essential oil composition in the spray is ethanol: plant essential oil composition ═ (2.5-5): 1, the mass ratio of the solubilizer to the plant essential oil composition is that the solubilizer: plant essential oil composition (1.25-1.5): 1, the mass percent of the film forming agent in the spray is 0.2-0.5%, and the mass percent of the preservative in the spray is 0.5-1%.
Preferably, the mass percentage of the plant essential oil composition in the spray is 4-8%.
Preferably, the mass ratio of the ethanol to the plant essential oil composition in the spray is ethanol: plant essential oil composition 3.5: 1, the mass ratio of the solubilizer to the plant essential oil composition is that the solubilizer: plant essential oil composition 1.35: 1, the mass percentage of the film forming agent in the spray is 0.35%.
Preferably, the solubilizer is PEG-40 hydrogenated castor oil, the film forming agent is polyurethane-35, and the preservative is phenoxyethanol and ethylhexyl glycerol.
Meanwhile, the invention also discloses application of the plant essential oil composition in the field of mosquito repellent products.
Compared with the prior art, the invention has the beneficial effects that: the plant essential oil composition is safe and non-irritant to skin, has the effect of repelling deet, and can provide a good mite removing effect. The spray prepared by the formula disclosed by the invention is convenient to use, and has fresh and cool skin without greasiness, and the mosquito repellent effect is durable.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
In the application, examples 1 to 5 and comparative examples 1 to 7 are both spray, and the plant essential oil composition in examples 1 to 5 is prepared by the formula disclosed by the invention.
The mixture ratio of the plant composition in examples 1 to 3 and comparative examples 1 to 5 is shown in table 1, and the spray comprises the following components in parts by weight: 6 parts of plant essential oil composition, 21 parts of ethanol, 8.1 parts of PEG-40 hydrogenated castor oil, 8.78 parts of polyurethane-350.35 parts of phenoxyethanol, 0.63 part of ethylhexyl glycerol and water until the weight is 100 parts.
In the sprays of examples 4 to 5 and comparative examples 6 to 7, the mass percent of phenoxyethanol, the mass percent of ethylhexyl glycerin and the mass percent of plant essential oil composition were 0.63%, 0.07% and 6%, respectively; the plant essential oil composition comprises the following components in parts by weight: 20 parts of balsam seed oil, 25 parts of lemon eucalyptus oil, 15 parts of thyme essential oil, 20 parts of milfoil essential oil and 20 parts of geranium essential oil; the remaining ingredients are shown in table 2.
The preparation methods of examples 1 to 5 and comparative examples 1 to 7 are as follows:
(1) mixing plant essential oil composition, alcohol and PEG-40 hydrogenated castor oil, stirring and dissolving to transparent state to obtain solution A;
(2) after the step (1) is finished, adding water into the solution A to obtain a solution B;
(3) and (3) after the step (2) is finished, adding polyurethane-35, phenoxyethanol and ethylhexylglycerin into the solution B, and uniformly stirring to obtain spray water.
Table 1 formulation (parts by weight) of plant essential oil composition in examples 1 to 3 and comparative examples 1 to 5
Table 2 mass percentages of some components in examples 4 to 5 and comparative examples 6 to 7
Performance testing
1. And (3) stability testing: reference QB/T2660-2004 cosmetic Water Standard
And (3) testing heat resistance: taking a sample, standing the sample at the temperature of 45 +/-1 ℃ for 90 days, and observing the sample;
cold resistance test: taking a sample, standing the sample at the temperature of (5 +/-1) ℃ for 90 days, and observing the sample;
and (3) testing the cyclicity: the sample is taken and kept stand at 45 ℃ for 12h, then kept stand at 5 ℃ for 12h, and observed after repeating 3 times.
Table 3 shows the results of the stability tests of examples 1 to 5 and comparative example 6.
TABLE 3 stability test results of examples 1 to 5 and comparative example 6
From table 3, it can be found that the spray water of examples 1 to 5 has good heat resistance, cold resistance and cycle performance, while the spray water of comparative example 6 has relatively small contents of ethanol and solubilizer and is unstable.
2. Antipruritic test
Mice were randomly divided into 9 groups, and the right hind paw of the mice was smeared with the examples 1 to 3, comparative examples 1 to 5, and blank control group at a dose of 10g/kg, and the blank control group was smeared with the same amount of distilled water. After 10min intervals, 0.05mL of a histamine phosphate solution with the mass percent of histamine phosphate of 0.01% is dripped on the wound surface of each mouse, and then 0.05mL of the histamine phosphate solution is dripped at every 3min interval, the concentration value of the histamine phosphate is increased by 0.0001 every time of dripping until the phenomenon that the mouse licks the right hind paw in a head return manner is caused, the total amount of the histamine phosphate given when the mouse licks the right hind paw in a head return manner is taken as an antipruritic threshold, and the test results are shown in Table 4.
TABLE 4 results of the antipruritic property test in examples 1 to 3 and comparative examples 1 to 5
As can be seen from Table 4, the higher antipruritic threshold of examples 1-3 indicates that the antipruritic spray prepared by applying the formula of the present invention has a better antipruritic effect. In addition, the highest antipruritic threshold of example 2 was found in examples 1-3, indicating that the formulations disclosed in example 2 have the best antipruritic properties.
3. And (3) bacteriostatic test: reference GB 15979-2002 hygienic standard of disposable sanitary article
According to the antibacterial performance test method of the product in annex C of GB 15979-2002 sanitary Standard for Disposable sanitary articles, the bacteria content is 1 multiplied by 104-9×104The bacterial suspension of cfu/mL is used for carrying out the bacteriostatic performance test, and the action time is 5 min. The test results are shown in table 5.
TABLE 5 results of tests on bacteriostatic ratio (%) -of examples 1 to 3 and comparative examples 1 to 5
From table 5, it can be found that the bacteriostatic rates of examples 1 to 3 are all more than 99%, and the bacteriostatic rates of comparative examples 1 to 5 are not more than 80%, indicating that the spray prepared by the mixture ratio disclosed by the invention has excellent bacteriostatic performance.
4. Mosquito repelling test: reference GB/T13917.9-2009 evasion agent evaluation standard
Selecting testers and test insects: 300 test insects are put into the mosquito cage, the back of the hand of a tester is exposed to the skin of 40mm multiplied by 40mm, and the rest part is tightly shielded. The hands are put into the mosquito cage for 2min, the mosquitoes are closely observed to stop falling, the arms are shaken to drive the mosquitoes away before the mouth organ of the mosquitoes penetrates into the skin, and the condition is recorded as that 1 test insect stops falling. More than 30 test persons who stop before and test insects are qualified for attack, and the person and the cage mosquitoes can be subjected to repellent tests.
Avoidance test: selecting 44 testers with qualified offensive power (half of male and female, and should not drink wine, tea or coffee before and during the test, and should not use essence-containing product), dividing into 11 groups, respectively drawing skin area of 50mm × 50mm on the back of each hand, and pressing 1.5 μ L/cm with one hand2The dose of (a) was evenly spread with the repellent to be tested, exposing 40mm x 40mm of skin therein, tightly shielding the rest, and the other hand was blank control. Smearing repellent for 2h, putting hands into mosquito cage with qualified attack power for 2min, and observing whether there is mosquito coming before and stopping and sucking blood. And then testing once every 1h, judging that the repellent fails as long as one mosquito sucks blood in front of the mosquito, and recording the effective protection time (h) of the repellent. The contrast test is firstly carried out by the contrast hand each time, the test insects with qualified attack force can be continuously tested, and the test insects with unqualified attack force can be tested by replacing the qualified test insects. The test results are shown in table 6. The effective protection time is the average of the effective protection times of 4 subjects per group (1 decimal left).
TABLE 6 mosquito repelling test results
As can be seen from table 6, the mosquito repelling time can be higher than 8h by using the sprays of examples 1 to 5, while the mosquito repelling time of the comparative examples is generally less than 5.5h, and since the amount of the film-forming agent used in example 7 is lower than the range disclosed by the invention, the effective time is slightly longer than that of the other comparative examples, but still lower than that of the mosquito repelling spray prepared by the formula disclosed by the invention.
5. Mite killing test: reference to NY/T1151.2-2006 standard for mite extermination and mite repellent testing
For each set of samples, 4 dishes were taken, of which 3 were added 10g of the sample to be tested. The other dish was not filled with the test agent as a control. The upper edge of the inner wall of each culture dish is evenly coated with white oil and vaseline mixture. 200 test insects are put in the center of each culture dish, 0.05g of mite feed is put in the center of each culture dish when 30min is needed, and then the culture dish is placed in a water-proof incubator. The dead mites were examined and recorded at 48 h. The test results are shown in table 7.
The calculation method comprises the following steps:
p-mite eradication Rate
R-number of dead test insects
N-number of test insects
TABLE 7 results of the test of the mite-killing rate in examples 1 to 3 and comparative examples 1 to 5
As can be seen from Table 7, the mite killing rate of the examples 1-3 is above 99%, wherein the mite killing rate of the example 2 can reach 100%, and all the examples reach the level of A-level mite killing.
6. Skin safety test: multiple complete skin tests
The test substance: 12 common New Zealand white rabbits, weighing 1.80-2.2kg, were provided by the Douxihua laboratory animal farm in the Kyowa City, Guangzhou city, with 4 rabbits per group of examples.
The test method comprises the following steps: the back hair on two sides of the spine of the back of the rabbit is removed 24 hours before the experiment, the skin surface is not damaged, and the hair removal ranges are respectively 3cm multiplied by 3 cm; applying 0.5g of the test substance on one side of skin with an application area of 2.5 × 2.5cm, and applying the other side of the skin as a control group without treatment for 1 time per day for 14 days; shearing hair from the next day before each smearing, and removing residual test substances by using pure water; the results were observed after one hour.
The skin irritation scores were made according to the skin irritation scoring standard of the technical Specification for cosmetic safety (2015 edition). The test results are shown in table 8.
TABLE 8 safety test results
As can be seen from Table 8, examples 1-5 are non-irritating to the skin, indicating that the mosquito repellent formulated with the formulation disclosed by the present invention is safe to the skin.
Finally, it should be noted that the above embodiments are only used for illustrating the technical solutions of the present invention and not for limiting the protection scope of the present invention, and although the present invention has been described in detail with reference to the preferred embodiments, it should be understood by those skilled in the art that modifications or equivalent substitutions can be made on the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention.
Claims (9)
1. The plant essential oil composition with the effects of repelling mosquitoes, relieving itching, inhibiting bacteria and killing mites is characterized by comprising the following components in parts by weight: 10-30 parts of balsam seed oil, 15-40 parts of lemon eucalyptus oil, 5-25 parts of thyme essential oil, 10-30 parts of milfoil essential oil and 10-30 parts of geranium essential oil.
2. The plant essential oil composition according to claim 1, which comprises the following components in parts by weight: 20 parts of balsam seed oil, 25 parts of lemon eucalyptus oil, 15 parts of thyme essential oil, 20 parts of milfoil essential oil and 20 parts of geranium essential oil.
3. A mosquito repellent spray comprising a plant essential oil composition according to any one of claims 1 to 2.
4. A mosquito repellent spray according to claim 3 further comprising ethanol, a solubilising agent, a film former and a preservative.
5. The mosquito-repellent spray according to claim 4, wherein the mass ratio of the ethanol to the plant essential oil composition in the spray is as follows: ethanol: plant essential oil composition = (2.5-5): 1, the mass ratio of the solubilizer to the plant essential oil composition is as follows: solubilizer: plant essential oil composition = (1.25-1.5): 1, the mass percent of the film forming agent in the spray is 0.2-0.5%, and the mass percent of the preservative in the spray is 0.5-1%.
6. A mosquito repellent spray according to any one of claims 3 to 5, wherein the mass percentage of the plant essential oil composition in the spray is 4-8%.
7. A mosquito repellent spray according to claim 5, wherein the mass ratio of the ethanol to the plant essential oil composition in the spray is: ethanol: plant essential oil composition = 3.5: 1, the mass ratio of the solubilizer to the plant essential oil composition is as follows: solubilizer: plant essential oil composition = 1.35: 1, the mass percentage of the film forming agent in the spray is 0.35%.
8. A mosquito repellent spray according to claim 7 wherein the solubiliser is PEG-40 hydrogenated castor oil, the film former is polyurethane-35 and the preservative is phenoxyethanol and ethylhexylglycerin.
9. Use of a plant essential oil composition according to any one of claims 1 to 2 in the preparation of a mosquito repellent product.
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| CN112545925B (en) * | 2020-12-22 | 2021-10-29 | 乐比(广州)健康产业有限公司 | Mosquito-repellent spray composition and preparation method thereof |
| CN112640922B (en) | 2020-12-24 | 2021-08-06 | 乐比(广州)健康产业有限公司 | Mosquito repellent composition and preparation method and application thereof |
| CN112891257B (en) * | 2021-01-26 | 2022-11-15 | 润本生物技术股份有限公司 | Mosquito-repellent composition and application thereof |
| CN113648249A (en) * | 2021-08-10 | 2021-11-16 | 福建香缘生物科技发展有限公司 | Pure natural plant bacteriostatic agent |
| CN115869197A (en) * | 2022-10-27 | 2023-03-31 | 双飞人制药股份有限公司 | Bacteriostatic itching-relieving agent |
| CN118873446B (en) * | 2024-09-30 | 2024-11-29 | 乐比(广州)健康产业有限公司 | A plant essential oil composition with mosquito repelling and after-sun soothing and repairing effects and its application |
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| CN108498378A (en) * | 2018-04-19 | 2018-09-07 | 厦门千鹰生物科技有限公司 | A kind of mosquito repellent, antipruritic, detumescence compound plant essential oil and its application |
| CN109169739B (en) * | 2018-07-19 | 2019-07-30 | 谭贤舜 | A kind of mosquito repelling composition, preparation and its application containing plants essential oil |
| CN110179693B (en) * | 2019-06-14 | 2022-09-16 | 江西中医药大学 | Mosquito-repellent and itching-repellent compound essential oil, preparation method, application, and mosquito-repellent and itching-repellent product |
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