CN110787119A - Antibacterial skin-care traditional Chinese medicine composition and preparation method and application thereof - Google Patents
Antibacterial skin-care traditional Chinese medicine composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN110787119A CN110787119A CN201911189605.9A CN201911189605A CN110787119A CN 110787119 A CN110787119 A CN 110787119A CN 201911189605 A CN201911189605 A CN 201911189605A CN 110787119 A CN110787119 A CN 110787119A
- Authority
- CN
- China
- Prior art keywords
- parts
- traditional chinese
- chinese medicine
- weight
- medicine composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 61
- 239000000203 mixture Substances 0.000 title claims abstract description 46
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 33
- 238000002360 preparation method Methods 0.000 title claims abstract description 16
- 241000132012 Atractylodes Species 0.000 claims abstract description 23
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 19
- 241000123835 Ampelopsis japonica Species 0.000 claims abstract description 18
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 13
- 239000012264 purified product Substances 0.000 claims abstract description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 49
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 43
- 239000000047 product Substances 0.000 claims description 27
- 229940079593 drug Drugs 0.000 claims description 19
- 230000001815 facial effect Effects 0.000 claims description 14
- 244000197580 Poria cocos Species 0.000 claims description 13
- 235000008599 Poria cocos Nutrition 0.000 claims description 13
- 102000019197 Superoxide Dismutase Human genes 0.000 claims description 12
- 108010012715 Superoxide dismutase Proteins 0.000 claims description 12
- 239000002537 cosmetic Substances 0.000 claims description 12
- 239000000284 extract Substances 0.000 claims description 11
- 239000000344 soap Substances 0.000 claims description 11
- 239000006071 cream Substances 0.000 claims description 9
- 238000005303 weighing Methods 0.000 claims description 9
- 241000563984 Ampelopsis Species 0.000 claims description 8
- 235000009388 Parthenocissus quinquefolia Nutrition 0.000 claims description 8
- 238000005406 washing Methods 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 7
- 229910021641 deionized water Inorganic materials 0.000 claims description 7
- 238000000605 extraction Methods 0.000 claims description 7
- -1 facial mask Substances 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 238000001914 filtration Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 238000002156 mixing Methods 0.000 claims description 7
- 238000000746 purification Methods 0.000 claims description 7
- 238000003756 stirring Methods 0.000 claims description 7
- 239000006228 supernatant Substances 0.000 claims description 7
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 6
- 229930182490 saponin Natural products 0.000 claims description 6
- 150000007949 saponins Chemical class 0.000 claims description 6
- 229930182478 glucoside Natural products 0.000 claims description 5
- 150000008131 glucosides Chemical class 0.000 claims description 5
- 239000000686 essence Substances 0.000 claims description 4
- 239000008269 hand cream Substances 0.000 claims description 4
- 239000011573 trace mineral Substances 0.000 claims description 4
- 235000013619 trace mineral Nutrition 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052802 copper Inorganic materials 0.000 claims description 3
- 239000010949 copper Substances 0.000 claims description 3
- 239000003599 detergent Substances 0.000 claims description 3
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 24
- 230000002087 whitening effect Effects 0.000 abstract description 10
- 208000003351 Melanosis Diseases 0.000 abstract description 8
- 206010014970 Ephelides Diseases 0.000 abstract description 5
- 241000894006 Bacteria Species 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 38
- 239000011049 pearl Substances 0.000 description 29
- 208000003251 Pruritus Diseases 0.000 description 21
- 238000012360 testing method Methods 0.000 description 15
- 235000019441 ethanol Nutrition 0.000 description 14
- 230000007803 itching Effects 0.000 description 10
- 230000001954 sterilising effect Effects 0.000 description 9
- WIONIXOBNMDJFJ-UHFFFAOYSA-N Dictamnine Chemical compound C1=CC=C2C(OC)=C(C=CO3)C3=NC2=C1 WIONIXOBNMDJFJ-UHFFFAOYSA-N 0.000 description 8
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 8
- 208000002193 Pain Diseases 0.000 description 8
- 206010010904 Convulsion Diseases 0.000 description 7
- 230000036461 convulsion Effects 0.000 description 7
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 7
- 239000000523 sample Substances 0.000 description 7
- 239000000341 volatile oil Substances 0.000 description 7
- 241000699666 Mus <mouse, genus> Species 0.000 description 6
- 230000001139 anti-pruritic effect Effects 0.000 description 6
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 6
- 230000002401 inhibitory effect Effects 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 229950005143 sitosterol Drugs 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 239000003440 toxic substance Substances 0.000 description 6
- 238000004140 cleaning Methods 0.000 description 5
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 description 5
- 238000004659 sterilization and disinfection Methods 0.000 description 5
- 231100000167 toxic agent Toxicity 0.000 description 5
- 241000193830 Bacillus <bacterium> Species 0.000 description 4
- PKRPFNXROFUNDE-LLVKDONJSA-N Byakangelicin Chemical compound O1C(=O)C=CC2=C1C(OC[C@@H](O)C(C)(C)O)=C1OC=CC1=C2OC PKRPFNXROFUNDE-LLVKDONJSA-N 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- WWNNZCOKKKDOPX-UHFFFAOYSA-N N-methylnicotinate Chemical compound C[N+]1=CC=CC(C([O-])=O)=C1 WWNNZCOKKKDOPX-UHFFFAOYSA-N 0.000 description 4
- 241000475481 Nebula Species 0.000 description 4
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 description 4
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 4
- 229960001231 choline Drugs 0.000 description 4
- LQGUBLBATBMXHT-UHFFFAOYSA-N chrysophanol Chemical compound C1=CC=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O LQGUBLBATBMXHT-UHFFFAOYSA-N 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 239000006210 lotion Substances 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- PKUBGLYEOAJPEG-UHFFFAOYSA-N physcion Natural products C1=C(C)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O PKUBGLYEOAJPEG-UHFFFAOYSA-N 0.000 description 4
- FFWOKTFYGVYKIR-UHFFFAOYSA-N physcion Chemical compound C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1O FFWOKTFYGVYKIR-UHFFFAOYSA-N 0.000 description 4
- 230000001737 promoting effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 208000002874 Acne Vulgaris Diseases 0.000 description 3
- TYPSVDGIQAOBAD-DZGCQCFKSA-N Atractylone Chemical compound C([C@]1(C)C2)CCC(=C)[C@@H]1CC1=C2OC=C1C TYPSVDGIQAOBAD-DZGCQCFKSA-N 0.000 description 3
- 244000293323 Cosmos caudatus Species 0.000 description 3
- 235000005956 Cosmos caudatus Nutrition 0.000 description 3
- 206010019233 Headaches Diseases 0.000 description 3
- 235000021314 Palmitic acid Nutrition 0.000 description 3
- 208000033809 Suppuration Diseases 0.000 description 3
- 208000025865 Ulcer Diseases 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 3
- 206010000496 acne Diseases 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 208000028659 discharge Diseases 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 206010015037 epilepsy Diseases 0.000 description 3
- 230000003179 granulation Effects 0.000 description 3
- 238000005469 granulation Methods 0.000 description 3
- 231100000869 headache Toxicity 0.000 description 3
- 229960001660 histamine phosphate Drugs 0.000 description 3
- ZHIBQGJKHVBLJJ-UHFFFAOYSA-N histamine phosphate Chemical compound OP(O)(O)=O.OP(O)(O)=O.NCCC1=CNC=N1 ZHIBQGJKHVBLJJ-UHFFFAOYSA-N 0.000 description 3
- 210000003097 mucus Anatomy 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 231100000397 ulcer Toxicity 0.000 description 3
- 210000001835 viscera Anatomy 0.000 description 3
- 230000037303 wrinkles Effects 0.000 description 3
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 description 2
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 description 2
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 description 2
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 description 2
- HFDVRLIODXPAHB-UHFFFAOYSA-N 1-tetradecene Chemical compound CCCCCCCCCCCCC=C HFDVRLIODXPAHB-UHFFFAOYSA-N 0.000 description 2
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 description 2
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 2
- VWDXGKUTGQJJHJ-UHFFFAOYSA-N Catenarin Natural products C1=C(O)C=C2C(=O)C3=C(O)C(C)=CC(O)=C3C(=O)C2=C1O VWDXGKUTGQJJHJ-UHFFFAOYSA-N 0.000 description 2
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 description 2
- 206010012504 Dermatophytosis Diseases 0.000 description 2
- 239000010282 Emodin Substances 0.000 description 2
- RBLJKYCRSCQLRP-UHFFFAOYSA-N Emodin-dianthron Natural products O=C1C2=CC(C)=CC(O)=C2C(=O)C2=C1CC(=O)C=C2O RBLJKYCRSCQLRP-UHFFFAOYSA-N 0.000 description 2
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 2
- XYYAFLHHHZVPRN-GXTWGEPZSA-N Fraxinellone Chemical compound C=1([C@@H]2OC(=O)C3=C(CCC[C@]32C)C)C=COC=1 XYYAFLHHHZVPRN-GXTWGEPZSA-N 0.000 description 2
- WPNOWVWMZUYEQO-UHFFFAOYSA-N Fraxinellone Natural products CC1=C2C(=O)OC(c3occc3)C2(C)CCC1 WPNOWVWMZUYEQO-UHFFFAOYSA-N 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- YOOXNSPYGCZLAX-UHFFFAOYSA-N Helminthosporin Natural products C1=CC(O)=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O YOOXNSPYGCZLAX-UHFFFAOYSA-N 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- UGNZSMZSJYOGNX-UHFFFAOYSA-N Isoviocristine Natural products O=C1C=C(C)C(=O)C2=CC3=CC(OC)=CC(O)=C3C(O)=C21 UGNZSMZSJYOGNX-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241001460074 Microsporum distortum Species 0.000 description 2
- 206010028748 Nasal obstruction Diseases 0.000 description 2
- QEOWFDYSNYCPRK-UHFFFAOYSA-N OCC[Na] Chemical compound OCC[Na] QEOWFDYSNYCPRK-UHFFFAOYSA-N 0.000 description 2
- 235000001188 Peltandra virginica Nutrition 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 241000588769 Proteus <enterobacteria> Species 0.000 description 2
- NTGIIKCGBNGQAR-UHFFFAOYSA-N Rheoemodin Natural products C1=C(O)C=C2C(=O)C3=CC(O)=CC(O)=C3C(=O)C2=C1O NTGIIKCGBNGQAR-UHFFFAOYSA-N 0.000 description 2
- 244000042430 Rhodiola rosea Species 0.000 description 2
- 235000003713 Rhodiola rosea Nutrition 0.000 description 2
- 241000220317 Rosa Species 0.000 description 2
- 241000447727 Scabies Species 0.000 description 2
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 208000002474 Tinea Diseases 0.000 description 2
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- WLXGUTUUWXVZNM-UHFFFAOYSA-N anthraglycoside A Natural products C1=C(C)C=C2C(=O)C3=CC(OC)=CC(O)=C3C(=O)C2=C1OC1OC(CO)C(O)C(O)C1O WLXGUTUUWXVZNM-UHFFFAOYSA-N 0.000 description 2
- 208000010668 atopic eczema Diseases 0.000 description 2
- TYPSVDGIQAOBAD-UHFFFAOYSA-N atractylone Natural products C1C2(C)CCCC(=C)C2CC2=C1OC=C2C TYPSVDGIQAOBAD-UHFFFAOYSA-N 0.000 description 2
- 229940076810 beta sitosterol Drugs 0.000 description 2
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 description 2
- PKRPFNXROFUNDE-UHFFFAOYSA-N biac-angelicin Natural products O1C(=O)C=CC2=C1C(OCC(O)C(C)(C)O)=C1OC=CC1=C2OC PKRPFNXROFUNDE-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- NZPQWZZXRKZCDU-UHFFFAOYSA-N chrysophanol Natural products Cc1cc(O)c2C(=O)c3c(O)cccc3Oc2c1 NZPQWZZXRKZCDU-UHFFFAOYSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 239000000645 desinfectant Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- RHMXXJGYXNZAPX-UHFFFAOYSA-N emodin Chemical compound C1=C(O)C=C2C(=O)C3=CC(C)=CC(O)=C3C(=O)C2=C1O RHMXXJGYXNZAPX-UHFFFAOYSA-N 0.000 description 2
- VASFLQKDXBAWEL-UHFFFAOYSA-N emodin Natural products OC1=C(OC2=C(C=CC(=C2C1=O)O)O)C1=CC=C(C=C1)O VASFLQKDXBAWEL-UHFFFAOYSA-N 0.000 description 2
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 description 2
- MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- 239000004088 foaming agent Substances 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N gallic acid Chemical compound OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 description 2
- 210000000548 hind-foot Anatomy 0.000 description 2
- 206010022437 insomnia Diseases 0.000 description 2
- IGWDEVSBEKYORK-UHFFFAOYSA-N isoimperatorin Chemical compound O1C(=O)C=CC2=C1C=C1OC=CC1=C2OCC=C(C)C IGWDEVSBEKYORK-UHFFFAOYSA-N 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000036564 melanin content Effects 0.000 description 2
- 230000008099 melanin synthesis Effects 0.000 description 2
- WFWNFBYXZQJMFM-UHFFFAOYSA-N methylcyclodecane Chemical compound CC1CCCCCCCCC1 WFWNFBYXZQJMFM-UHFFFAOYSA-N 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 208000005687 scabies Diseases 0.000 description 2
- 231100000241 scar Toxicity 0.000 description 2
- RODXRVNMMDRFIK-UHFFFAOYSA-N scopoletin Chemical compound C1=CC(=O)OC2=C1C=C(OC)C(O)=C2 RODXRVNMMDRFIK-UHFFFAOYSA-N 0.000 description 2
- 235000015500 sitosterol Nutrition 0.000 description 2
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 description 2
- 208000017520 skin disease Diseases 0.000 description 2
- 210000000952 spleen Anatomy 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 235000019640 taste Nutrition 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- 229940126680 traditional chinese medicines Drugs 0.000 description 2
- 230000002936 tranquilizing effect Effects 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- QTAGQHZOLRFCBU-CYBMUJFWSA-N (+)-oxypeucedanin Chemical compound CC1(C)O[C@@H]1COC1=C(C=CO2)C2=CC2=C1C=CC(=O)O2 QTAGQHZOLRFCBU-CYBMUJFWSA-N 0.000 description 1
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- KQQXUARABJGCMS-UHFFFAOYSA-N 3-methylbutyl 2-hydroxy-2-phenylacetate Chemical group CC(C)CCOC(=O)C(O)C1=CC=CC=C1 KQQXUARABJGCMS-UHFFFAOYSA-N 0.000 description 1
- ZPSAEGUNYMEKBP-UHFFFAOYSA-N 5-Isopentenyloxy-psoralen Natural products CC(C)C=COc1c2C=CC(=O)Oc2cc3occc13 ZPSAEGUNYMEKBP-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241000238876 Acari Species 0.000 description 1
- 208000020154 Acnes Diseases 0.000 description 1
- BEYIWVKWKJROGZ-UHFFFAOYSA-N Alloimperatorin Natural products O1C(=O)C=CC2=C1C(O)=C1OC=CC1=C2OCC=C(C)C BEYIWVKWKJROGZ-UHFFFAOYSA-N 0.000 description 1
- 235000009051 Ambrosia paniculata var. peruviana Nutrition 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 241000209524 Araceae Species 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000003097 Artemisia absinthium Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- 235000017731 Artemisia dracunculus ssp. dracunculus Nutrition 0.000 description 1
- 235000003261 Artemisia vulgaris Nutrition 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 241000208838 Asteraceae Species 0.000 description 1
- 241000092665 Atractylodes macrocephala Species 0.000 description 1
- FXNFHKRTJBSTCS-UHFFFAOYSA-N Baicalein Natural products C=1C(=O)C=2C(O)=C(O)C(O)=CC=2OC=1C1=CC=CC=C1 FXNFHKRTJBSTCS-UHFFFAOYSA-N 0.000 description 1
- 244000036905 Benincasa cerifera Species 0.000 description 1
- 235000011274 Benincasa cerifera Nutrition 0.000 description 1
- 241001313857 Bletilla striata Species 0.000 description 1
- 240000001548 Camellia japonica Species 0.000 description 1
- 241000282461 Canis lupus Species 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 244000020518 Carthamus tinctorius Species 0.000 description 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 1
- 206010007882 Cellulitis Diseases 0.000 description 1
- 206010008190 Cerebrovascular accident Diseases 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- 206010008631 Cholera Diseases 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 241001391944 Commicarpus scandens Species 0.000 description 1
- 241000382825 Cristaria plicata Species 0.000 description 1
- 229920000832 Cutin Polymers 0.000 description 1
- 241000157862 Dicamptodontidae Species 0.000 description 1
- 244000182625 Dictamnus albus Species 0.000 description 1
- XEHFSYYAGCUKEN-UHFFFAOYSA-N Dihydroscopoletin Natural products C1CC(=O)OC2=C1C=C(OC)C(O)=C2 XEHFSYYAGCUKEN-UHFFFAOYSA-N 0.000 description 1
- 206010013887 Dysarthria Diseases 0.000 description 1
- WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
- 208000004929 Facial Paralysis Diseases 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 244000308760 Helichrysum petiolatum Species 0.000 description 1
- 240000000950 Hippophae rhamnoides Species 0.000 description 1
- 235000003145 Hippophae rhamnoides Nutrition 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 1
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 1
- 102000004856 Lectins Human genes 0.000 description 1
- 108090001090 Lectins Proteins 0.000 description 1
- 241000589902 Leptospira Species 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 241001071917 Lithospermum Species 0.000 description 1
- 241000218378 Magnolia Species 0.000 description 1
- 241000217407 Margaritifera Species 0.000 description 1
- KGGUASRIGLRPAX-UHFFFAOYSA-N Meranzin hydrate Natural products C1=CC(=O)OC2=C(CC(O)C(C)(C)O)C(OC)=CC=C21 KGGUASRIGLRPAX-UHFFFAOYSA-N 0.000 description 1
- VCUFZILGIRCDQQ-KRWDZBQOSA-N N-[[(5S)-2-oxo-3-(2-oxo-3H-1,3-benzoxazol-6-yl)-1,3-oxazolidin-5-yl]methyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C1O[C@H](CN1C1=CC2=C(NC(O2)=O)C=C1)CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F VCUFZILGIRCDQQ-KRWDZBQOSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- QTAGQHZOLRFCBU-UHFFFAOYSA-N Oxypeucadanin Natural products CC1(C)OC1COC1=C(C=CO2)C2=CC2=C1C=CC(=O)O2 QTAGQHZOLRFCBU-UHFFFAOYSA-N 0.000 description 1
- NUCBCBCPICFGMZ-UHFFFAOYSA-N Oxypeucedanin Natural products CC1(C)OC1COC1=CC(=O)OC2=C1C=C1C=COC1=C2 NUCBCBCPICFGMZ-UHFFFAOYSA-N 0.000 description 1
- MWEVYJRFLDKUCW-UHFFFAOYSA-N Oxypeucedonin-hydrat Natural products CC(C)(O)C(O)Cc1c2C=CC(=O)Oc2cc3occc13 MWEVYJRFLDKUCW-UHFFFAOYSA-N 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical class [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 240000005373 Panax quinquefolius Species 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241000972672 Phellodendron Species 0.000 description 1
- 241000227425 Pieris rapae crucivora Species 0.000 description 1
- 241000490567 Pinctada Species 0.000 description 1
- 241000222341 Polyporaceae Species 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
- 206010039085 Rhinitis allergic Diseases 0.000 description 1
- 206010039101 Rhinorrhoea Diseases 0.000 description 1
- 241001093501 Rutaceae Species 0.000 description 1
- 241000316658 Sauromatum giganteum Species 0.000 description 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000607760 Shigella sonnei Species 0.000 description 1
- 206010067868 Skin mass Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 1
- 239000004473 Threonine Substances 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- 208000037386 Typhoid Diseases 0.000 description 1
- 241000746716 Typhonium Species 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 208000036826 VIIth nerve paralysis Diseases 0.000 description 1
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 1
- 241000934136 Verruca Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 240000006365 Vitis vinifera Species 0.000 description 1
- 235000014787 Vitis vinifera Nutrition 0.000 description 1
- 208000000260 Warts Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 201000010105 allergic rhinitis Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 230000001754 anti-pyretic effect Effects 0.000 description 1
- 229940121375 antifungal agent Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 239000002221 antipyretic Substances 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000001138 artemisia absinthium Substances 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- UDFLTIRFTXWNJO-UHFFFAOYSA-N baicalein Chemical compound O1C2=CC(=O)C(O)=C(O)C2=C(O)C=C1C1=CC=CC=C1 UDFLTIRFTXWNJO-UHFFFAOYSA-N 0.000 description 1
- 229940015301 baicalein Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- QXMNTPFFZFYQAI-IMDKZJJXSA-N beta-sitosterol 3-O-beta-D-glucopyranoside Natural products CC[C@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)O[C@@H]5C[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O)C(C)C QXMNTPFFZFYQAI-IMDKZJJXSA-N 0.000 description 1
- 229930006974 beta-terpinene Natural products 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 230000020411 cell activation Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 229960005233 cineole Drugs 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 235000018597 common camellia Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 235000001671 coumarin Nutrition 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- NPJICTMALKLTFW-OFUAXYCQSA-N daucosterol Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NPJICTMALKLTFW-OFUAXYCQSA-N 0.000 description 1
- QDFKFNAHVGPRBL-UHFFFAOYSA-N daucosterol Natural products CCC(CCC(C)C1CCC2C1CCC3C2(C)CC=C4CC(CCC34C)OC5OC(CO)C(O)C(O)C5O)C(C)C QDFKFNAHVGPRBL-UHFFFAOYSA-N 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 230000000916 dilatatory effect Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000012154 double-distilled water Substances 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000008686 ergosterol biosynthesis Effects 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002190 fatty acyls Chemical group 0.000 description 1
- 229940074391 gallic acid Drugs 0.000 description 1
- 235000004515 gallic acid Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 208000014617 hemorrhoid Diseases 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 210000003630 histaminocyte Anatomy 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- OLOOJGVNMBJLLR-UHFFFAOYSA-N imperatorin Chemical compound C1=CC(=O)OC2=C1C=C1C=COC1=C2OCC=C(C)C OLOOJGVNMBJLLR-UHFFFAOYSA-N 0.000 description 1
- XKVWLLRDBHAWBL-UHFFFAOYSA-N imperatorin Natural products CC(=CCOc1c2OCCc2cc3C=CC(=O)Oc13)C XKVWLLRDBHAWBL-UHFFFAOYSA-N 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- XDROKJSWHURZGO-UHFFFAOYSA-N isopsoralen Natural products C1=C2OC=CC2=C2OC(=O)C=CC2=C1 XDROKJSWHURZGO-UHFFFAOYSA-N 0.000 description 1
- 150000004715 keto acids Chemical class 0.000 description 1
- 239000002523 lectin Substances 0.000 description 1
- KBDSLGBFQAGHBE-MSGMIQHVSA-N limonin Chemical compound C=1([C@H]2[C@]3(C)CC[C@H]4[C@@]([C@@]53O[C@@H]5C(=O)O2)(C)C(=O)C[C@@H]2[C@]34COC(=O)C[C@@H]3OC2(C)C)C=COC=1 KBDSLGBFQAGHBE-MSGMIQHVSA-N 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- MQYXUWHLBZFQQO-QGTGJCAVSA-N lupeol Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)CC[C@@H](C(=C)C)[C@@H]5[C@H]4CC[C@@H]3[C@]21C MQYXUWHLBZFQQO-QGTGJCAVSA-N 0.000 description 1
- PKGKOZOYXQMJNG-UHFFFAOYSA-N lupeol Natural products CC(=C)C1CC2C(C)(CCC3C4(C)CCC5C(C)(C)C(O)CCC5(C)C4CCC23C)C1 PKGKOZOYXQMJNG-UHFFFAOYSA-N 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000000401 methanolic extract Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 208000010753 nasal discharge Diseases 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- HRWVKZXRZVVBLP-UHFFFAOYSA-N oxypeucedanin hydrate Natural products CC(C)(O)C(O)CCc1c2C=CC(=O)Oc2cc3occc13 HRWVKZXRZVVBLP-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 208000017983 photosensitivity disease Diseases 0.000 description 1
- 231100000434 photosensitization Toxicity 0.000 description 1
- 229930184064 pinicolic acid Natural products 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- MLMVLVJMKDPYBM-UHFFFAOYSA-N pseudoisopsoralene Natural products C1=C2C=COC2=C2OC(=O)C=CC2=C1 MLMVLVJMKDPYBM-UHFFFAOYSA-N 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 235000019633 pungent taste Nutrition 0.000 description 1
- 230000001047 pyretic effect Effects 0.000 description 1
- 230000004223 radioprotective effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000002000 scavenging effect Effects 0.000 description 1
- FWYIBGHGBOVPNL-UHFFFAOYSA-N scopoletin Natural products COC=1C=C2C=CC(OC2=C(C1)O)=O FWYIBGHGBOVPNL-UHFFFAOYSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 235000004400 serine Nutrition 0.000 description 1
- 229940115939 shigella sonnei Drugs 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 208000026473 slurred speech Diseases 0.000 description 1
- 230000037339 smooth wrinkles Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000002048 spasmolytic effect Effects 0.000 description 1
- 238000010183 spectrum analysis Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 235000008521 threonine Nutrition 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- 201000008297 typhoid fever Diseases 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940035893 uracil Drugs 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 231100000611 venom Toxicity 0.000 description 1
- 239000000052 vinegar Substances 0.000 description 1
- 235000021419 vinegar Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 210000004885 white matter Anatomy 0.000 description 1
- SCWPFSIZUZUCCE-UHFFFAOYSA-N β-terpinene Chemical compound CC(C)C1=CCC(=C)CC1 SCWPFSIZUZUCCE-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9728—Fungi, e.g. yeasts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/38—Products with no well-defined composition, e.g. natural products
- C11D3/382—Vegetable products, e.g. soya meal, wood flour, sawdust
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D9/00—Compositions of detergents based essentially on soap
- C11D9/04—Compositions of detergents based essentially on soap containing compounding ingredients other than soaps
- C11D9/22—Organic compounds, e.g. vitamins
- C11D9/38—Products in which the composition is not well defined
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/10—General cosmetic use
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to an antibacterial skin-care traditional Chinese medicine composition, a preparation method and application thereof, wherein the composition is a purified product extracted and purified from seven white formulas which are composed of the following seven raw materials: 60-100 parts of angelica dahurica, 60-100 parts of bighead atractylodes rhizome, 60-100 parts of ampelopsis japonica, 60-100 parts of white poria, 60-100 parts of cortex dictamni, 60-100 parts of rhizoma typhonii and 6-10 parts of pearl. Compared with the prior art, the invention has the effects of resisting bacteria, whitening skin, removing freckles and the like.
Description
Technical Field
The invention relates to the field of cosmetics, in particular to an antibacterial skin-care traditional Chinese medicine composition for cosmetics such as medicated soap and washing.
Background
Along with the improvement of living standard of people, the requirements of people on self conditions are increasingly improved, and the emphasis on skin care is also increasingly high. The demand for cleansing products is no longer limited to cleansing, but rather, it is desirable to have more skin care efficacy properties while cleansing the skin. At present, a lot of facial cleanser and solid soap type facial cleaning products appear on the market, and some products have good cleaning capability, but have strong alkalinity and large irritation to skin, so that the skin can be tense after washing; some products have good cleaning effect, are mild and non-irritant, but have single function; some products are added with chemical components which are not beneficial to human bodies, such as synthetic perfume, silicon, viscous agent, foaming agent, emulsifier and the like, and are easy to cause damage to the skin.
Therefore, the Chinese patent application CN201910450929.7 discloses a sterilizing and itching relieving medicinal soap which is characterized by comprising ozone salt, fatty acyl hydroxyethyl sodium sulfonate and the following raw materials in parts by weight: 5-10 parts of lithospermum oil, 2-6 parts of evening primrose oil, 3-8 parts of rose essential oil, 4-8 parts of rhodiola rosea essential oil, 5-8 parts of wormwood essential oil, 0.5-10 parts of giant salamander mucus extract, 1-5 parts of tremella polysaccharide, 20-35 parts of itching relieving traditional Chinese medicine water extract, 20-30 parts of cocamidopropyl betaine, 25-40 parts of foaming agent, 150-250 parts of cocoyl hydroxyethyl sodium sulfonate and 50-75 parts of soap particles; although the disinfectant has the effects of sterilizing and relieving itching, the disinfectant has various formula components and complex preparation method, contains partial chemicals and has great side effect.
Patent application CN201710893387.1 discloses a plant extract for whitening skin and resisting wrinkles and a preparation method thereof, the plant extract is prepared by using rhodiola rosea, helichrysum, camellia, rhizoma typhonii, bletilla striata, ginseng, safflower, radix paeoniae alba, radix angelicae, bighead atractylodes rhizome, rose, grape seeds and sea buckthorn as raw materials and adopting a preparation process of extracting with ethanol; the invention can effectively inhibit the generation of melanin, accelerate the metabolism of the melanin, improve the problems of rough skin and color spots, promote microcirculation, accelerate the renewal of skin cells, contribute to the synthesis of collagen, improve dark yellow complexion, relieve epidermal skin and smooth wrinkles, and can be prepared into facial cleanser, toning lotion, essence, cream, eye cream, facial mask, hand cream and body lotion. Although the extract disclosed in the patent can achieve whitening and antibacterial effects, the raw materials are complex, part of the raw materials are expensive, the popularization is not facilitated, and in addition, the function is single, and the effect is poor.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide an antibacterial skin-care traditional Chinese medicine composition, and a preparation method and application thereof.
The purpose of the invention can be realized by the following technical scheme: the antibacterial skin-care traditional Chinese medicine composition is characterized by being a purified product extracted and purified from a seven-white formula consisting of the following seven raw materials, wherein the seven-white formula comprises the following components in parts by weight: 60-100 parts of angelica dahurica, 60-100 parts of bighead atractylodes rhizome, 60-100 parts of ampelopsis japonica, 60-100 parts of white poria, 60-100 parts of cortex dictamni, 60-100 parts of rhizoma typhonii and 6-10 parts of pearl.
The composition is a seven-white formula consisting of the following seven raw materials: 80-85 parts of angelica dahurica, 80-85 parts of bighead atractylodes rhizome, 80-85 parts of ampelopsis japonica, 80-85 parts of white poria, 80-85 parts of cortex dictamni, 80-85 parts of rhizoma typhonii and 8-9 parts of pearl.
The pearls are white pearls which are crushed to be 500-600 meshes.
The preparation method of the antibacterial skin-care traditional Chinese medicine composition comprises the following steps:
(1) extraction of
Weighing 60-100 parts by weight of radix angelicae, 60-100 parts by weight of bighead atractylodes rhizome, 60-100 parts by weight of radix ampelopsis, 60-100 parts by weight of poria cocos, 60-100 parts by weight of cortex dictamni and 60-100 parts by weight of rhizoma typhonii, adding water for decoction, extracting for 2 times, adding water for the first time, wherein the water amount is 6-10 times of the total weight of the six components, decocting for 0.5-2 hours, adding water for the second time, wherein the water amount is 6-10 times of the total weight of the six components, decocting for 0.1-1 hour, filtering, combining filtrates, and concentrating to 0.5-2 g crude drug/mL at normal pressure for later use;
(2) purification of
Adding ethanol with the weight being 1-3 times that of the water extract concentrated solution obtained in the step (1), stirring while adding, standing for 10-15 hours, separating supernatant, concentrating under reduced pressure until no alcohol smell exists, concentrating under reduced pressure at 50-80 ℃ to 0.5-2 g crude drug/ml, adding 6-10 parts by weight of pearl, and fully mixing.
The water added in the step (1) is deionized water.
The composition product obtained in the step (2) contains 0.1-1 wt% of saponin and 0.1-1 wt% of glucoside.
The composition product obtained in the step (2) contains 0.1-1 wt% of SOD (superoxide dismutase) components, wherein the SOD components comprise three trace elements of manganese, copper and zinc.
The application of the antibacterial skin-care traditional Chinese medicine composition is characterized in that the purified products (namely the traditional Chinese medicine composition) obtained by extracting and purifying seven components in the seven-component formula are used in cosmetics or washing products, the cosmetics comprise facial cleanser, cosmetic water, essence, cream, eye cream, facial mask, hand cream, body lotion and the like, and the washing products comprise perfumed soap, medicated soap, laundry detergent and the like.
The seven-white prescription of the invention adopts seven white traditional Chinese medicines, so that the components have synergistic effect and obtain good antibacterial and skin-care effects:
1. root of Dahurian Angelica
The product is dried root of Angelica dahurica (Fisch. ex Hoffm.) Benth.ethook.f. or Angelica dahurica (Fisch. ex Hoffm.) Benth.ethook.f. var. fortmosana (Boiss.) Shann et Yuan. The product has effects in relieving exterior syndrome, dispelling cold, expelling pathogenic wind, relieving pain, dredging nasal orifice, eliminating dampness, relieving leukorrhagia, and promoting pus discharge, and can be used for treating common cold, headache, supercilium pain, nasal obstruction, nasal discharge, allergic rhinitis, nasosinusitis, toothache, leukorrhagia, and sore and ulcer with swelling and pain.
The radix Angelicae Dahuricae contains volatile oil, 29 compounds with high contents of methylcyclodecane, 1-tetradecene, ethyl laurate, and furocoumarin are detected in the volatile oil. In addition, it also contains imperatorin, angelicin, scopoletin, byak-angelicin, isoimperatorin, hydrated byak-angelicin, iso-hui-angelicin, oxypeucedanin, anethole, carvacrol, palmitic acid, etc.
The traditional Chinese medicine considers that the angelica dahurica is warm in nature and pungent in taste, enters the channels of the lung, the spleen and the stomach, dispels wind-damp, promotes blood circulation, expels pus, promotes granulation and relieves pain. Can be used for treating headache, toothache, nasosinusitis, hemorrhoid, leucorrhea with red and white discharge, carbuncle, cellulitis, pyocutaneous disease, skin pruritus, relieving exterior syndrome, dispelling cold, dispelling pathogenic wind, relieving pain, relieving nasal obstruction, eliminating dampness, stopping leukorrhagia, and relieving swelling and pus discharge.
Pharmacological research shows that the water decoction also has inhibitory effect on various bacteria such as Escherichia coli, Shigella sonnei, Proteus, typhoid bacillus, paratyphoid bacillus, Pseudomonas aeruginosa, cholera bacillus, etc. It also has effect in inhibiting human type tubercle bacillus, and the methanol extract has radioprotective effect. In addition, the composition has antipyretic, analgesic and anti-inflammatory effects; shortening blood coagulation time, dilating coronary blood vessel, and lowering blood pressure; photosensitization; has antimicrobial effect.
2 white atractylodes rhizome
The product is named as English: RHIZOMAATRACTYLODIS MACROCEPHHAAE is prepared from Atractylodes macrocephala of Compositae, and has gray yellow or gray brown surface, nodular protrusion, intermittent longitudinal wrinkle and furrow, fibrous root scar, and residual stem base and bud scar at top. Hard and hard, not easy to break, uneven section, yellowish white to light brown, and brownish yellow point-shaped oil chamber dispersed; the dried cutin has darker color or cracks. Fragrant smell, sweet and slightly pungent taste, and slightly sticky when chewed.
The white atractylodes rhizome mainly contains 1.4 percent of volatile oil, contains 1.4 percent of Atractylol (atractyl ol), atractylone (atractylenon) and the like as main components, and also contains vitamin A, the rhizome contains about 1.4 percent of volatile oil, the oil contains atractylone (a-tetractylenone), and also contains atractylenolide A, B, apine dienone [ selina-4(14), 7(11) -dienone ], β -terpinene (β -Se-ene), eucalyptol (eucalyptus-terpene), oxygen coumarines (oxicoumarines), saccharides, resins and the like.
The white atractylodes rhizome has special effects on whitening skin. It has inhibitory effect on dermatophytosis such as dermatophytosis. Ancient book "medical property treatise": "have beautiful main face, retain youthful looks and remove spots. White atractylodes rhizome is dipped in wine (or vinegar) in the form of ground ink and is uniformly applied to the face, so that the face-beautifying wine can whiten the skin, clear heat and dry dampness, kill mites and remove acnes, and can treat freckles and black spots. The Sheng Yi Li Shizhen says that the formula treats the freckles' extremely. The widely spread traditional Chinese medicine beautifying formula Saibai soup recorded in Ming Dynasty (16 th century) medical works "medical entry" is described as follows: the white atractylodes rhizome can tonify qi and blood, whiten and moisten skin, and is suitable for rough skin, sallow complexion, chloasma, pigmentation and the like caused by deficiency-cold of qi and blood. In traditional Chinese medicine, whether the skin of a person is beautiful or not is considered to have close relationship with the functions of the viscera, and if the viscera are diseased and qi and blood are not harmonized, the skin is rough and spots are generated on the face. Therefore, the formula starts with the functions of regulating qi and blood and regulating the five internal organs, thereby whitening and removing freckles.
3 Ampelopsis japonica
The product has the name of Ampelopsis japonica: japanese Ampelopsis Root. Root tuber of Ampelopsis japonica (Thunb.) Makino, a family Vitaceae. And (5) making the vine. The stem is branched with pale purple color, scattered and punctate skin pores, and the tendrils and leaves are opposite. Palm compound leaves grow alternately, 3-5 small leaves, part of the leaves are divided into pinnate parts, part of the leaves are carved, the edges are thinned with coarse saw teeth, the leaf axis is provided with wide wings, joints are arranged at the base parts of the divided leaves, and both sides are hairless. The parasol inflorescence and the leaves are opposite, and the inflorescence peduncle is slender and wound; small flower, sepal 5; petal 5, light yellow; a stamen 5; the flower disc is cup-shaped with slightly split edges. Berry is spherical or kidney-shaped, blue or white when cooked, and has pinhole-shaped pits.
The physical and chemical properties and spectral analysis of the Ampelopsis japonica (Thunb.) are identified as physcion, lupeol, β -sitosterol, chrysophanol, hexadecanoic acid, emodin, fumaric acid, daucosterol, gallic acid and dulcitol, wherein physcion, chrysophanol, emodin, fumaric acid and dulcitol are firstly obtained from the Ampelopsis.
The ampelopsis japonica contains a large amount of mucus and starch, has fine white matter, has excellent beautifying effect, can eliminate facial acne, can eliminate stagnation and relieve pain, can also eliminate dermatitis, can reduce the harm of fungi to human skin, and can also eliminate facial acne and color spots. The ampelopsis japonica can lighten spots and whiten the skin, twenty grams of the ampelopsis japonica can be added into nine grams of biond magnolia flower and thirty-ten grams of white gourd tripe, fifteen grams of angelica and fifteen grams of flour after the color spots appear in normal times, the traditional Chinese medicines are ground, uniformly mixed and decocted to obtain medicinal liquid, the medicinal liquid is added into the flour to be mixed into paste to be directly applied externally, three to four times per week, the color spots can be lightened quickly, and the whitening effect is very obvious.
4 white poria
The product is dried cortex of Wolf sclerotium of Poria cocos Cos (Schw.) belonging to Polyporaceae. Digging more than 7-9 months, collecting the cut skin when processing Poria slices and Poria blocks, and drying in the shade. The product is in the form of strip or irregular pieces with different sizes. The outer surface is tan to black, with warty processes, and the inner surface is light brown and often has a white or light red subcutaneous part. It is soft and slightly elastic. Light smell, light taste, sticky teeth when chewed.
The Poria cocos comprises Isopolysaccharide (pachyman), Isoacid (pachymacic), baicalein (tumulosicacrl), buccolinic acid (eburicoxicalcl), pinicolic acid (pinicolic), ergosterol (ergosterol), etc.
The tuckahoe has the effects of excreting dampness and promoting diuresis, tonifying spleen and stomach, calming heart and soothing nerves. The antibacterial effect of the white poria is as follows: the 100% decoction of Poria has inhibitory effect on Staphylococcus aureus, Escherichia coli, and Proteus by plate punching. The result of the test on the bacteriostasis by the test tube method is that the tuckahoe has no bacteriostasis. The ethanol extract of Poria was found to kill leptospira in vitro, but the water decoction was not effective.
5 cortex Dictamni Radicis
The product is dried root bark of Dictamnus dasycarpus Turcz of Rutaceae. Digging root in spring and autumn, removing silt and rough bark, stripping root bark, and drying. The product is in the shape of a reel, and has a length of 5-15 cm, a diameter of 1-2 cm, and a thickness of 0.2-0.5 cm. The outer surface is gray white or light gray yellow, has fine longitudinal wrinkles and fine root marks and is often provided with protruded granular small points; the inner surface is white-like and has fine longitudinal lines. The product is crisp, dust flies when broken, the section is uneven and is slightly lamellar, and the outer layer is peeled off, so that a small bright spot which flickers when meeting light can be seen. Has smell of mutton and slightly bitter taste.
The cortex Dictamni Radicis contains Dictamnine (Dictamnine), Trigonelline (Trigonelline), Choline (Choline), dictamnolide (Dic-tamnolactone, Objunactone), dictamnolide (Dictam-lactone), Sitosterol (Sitosterol), Fraxinellone (Fraxinellone), obanone (Objunone), and phellodendron ketoacid (Objunonica). Also contains fatty acid and crude saponin.
Cortex dictamni is a commonly used traditional Chinese medicine. Has effects in clearing away heat, eliminating dampness, dispelling pathogenic wind, and removing toxic substances. It is commonly used for treating damp-heat sore, yellow water dripping, eczema, scabies, sore, scabies, rheumatism and pyretic arthralgia. The cortex Dictamni Radicis has effects of dispelling pathogenic wind, eliminating dampness, clearing heat, and removing toxic substance. Cortex Dictamni Radicis has effects of clearing heat and detoxicating, eliminating dampness and relieving itching in dermatology, can be used for treating dermatogic diseases such as tinea pedis, verruca plana, skin pruritus, urticaria, eczema, etc., and has good antiallergic effect and itching relieving effect. Antibacterial and antipruritic effects, and cortex Dictamni Radicis has broad-spectrum fungus inhibiting effect. The action mechanism is that dictamnine influences the normal synthesis of cell genetic materials, so that the dictamnine cannot complete normal cell cycle and has no influence on sterol biosynthesis pathway, and traditional antifungal agents are all used for synthesizing ergosterol biosynthesis inhibitors. The cortex Dictamni Radicis extract has antipruritic effect. Pruritus is a common symptom of skin diseases. Histamine, one of the inflammatory mediators released by mast cell activation degranulation due to a recognized allergy, can cause skin itching, and anti-itching is also part of the treatment of skin diseases.
6 rhizoma Typhonii
Giant typhonium rhizome, the name of traditional Chinese medicine. Is a dried tuber of Typhonium giganteum Engl. of Araceae. Collected in autumn, removed fibrous root and peel, and dried in the sun. Has effects of dispelling pathogenic wind and phlegm, arresting convulsion, removing toxic substance, resolving hard mass, and relieving pain. Can be used for treating phlegm accumulation due to apoplexy, facial paralysis, slurred speech, convulsion, epilepsy, tetanus, phlegm syncope, headache, lymphoid tuberculosis, subcutaneous nodule, and venomous snake bite.
Rhizoma Typhonii contains β -sitosterol and its glucoside, meso-inositol, mucus, sucrose, and optionally saponin, and optionally choline, uracil, succinic acid, palmitic acid, linoleic acid, oleic acid, rhizoma Typhonii lectin, rhizoma Typhonii choline, trilinoleic acid, and dipalmitoyl glyceride.
The rhizoma Typhonii contains saponin, glucoside, etc., and has effects of eliminating melanin pigmentation on face, whitening skin, and removing freckle, acne, and erythra. Dispelling pathogenic wind and phlegm, arresting convulsion, removing toxic substance, resolving hard mass, and relieving pain.
7 Pearl
The Margarita product is prepared from bivalves such as Hyriopisi cumini (Lea) or Cristaria plicata (Leach) of Pinctada of Margaritifera. Taking out from animal body, cleaning, and drying. Has the effects of tranquilizing, arresting convulsion, improving eyesight, removing nebula, removing toxic substance, promoting granulation, moistening skin, and removing speckle. Can be used for treating pavor, insomnia, infantile convulsion, epilepsy, conjunctival congestion, nebula, unhealing sore and ulcer, and skin mottle.
The organic substance in Margarita contains 17 amino acids such as aspartic acid, threonine, serine, glutamic acid, glycine, alanine, cystine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, histidine, arginine, and proline. In addition, it also contains more than 30 kinds of trace elements, taurine, abundant vitamins and peptides.
The pearl contains three trace elements of manganese, copper, zinc and the like which are components for forming SOD, and the pearl powder is coated on the surface of the pearl, which can promote the activity of superoxide dismutase (SOD) of human skin, inhibit the synthesis of melanin and keep the skin white. In addition, because SOD has the function of scavenging free radicals, the pearl powder can prevent skin aging and wrinkling when being coated on the surface. Has the effects of tranquilizing, arresting convulsion, improving eyesight, removing nebula, removing toxic substance, promoting granulation, moistening skin, and removing speckle. Can be used for treating pavor, insomnia, infantile convulsion, epilepsy, conjunctival congestion, nebula, unhealing sore and ulcer, and skin mottle.
Compared with the prior art, the invention adopts seven common white components in the traditional Chinese medicine: the seven medicines respectively belong to exterior-syndrome-relieving and cold-dispelling medicines, wind-dispelling and toxicity-dispelling medicines and heat-clearing and toxicity-dispelling medicines in traditional Chinese medicine classification, and have good antibacterial efficacy after being compounded, and also have the effects of inhibiting synthesis of melanin, whitening skin, removing freckles and the like. Especially, the contents of saponin and glucoside contained in the composition product can promote the stable dispersion of SOD and improve the antibacterial and skin-care effects.
Detailed Description
The following examples are given for the detailed implementation and specific operation of the present invention, but the scope of the present invention is not limited to the following examples.
Example 1
An antibacterial skin-care traditional Chinese medicine composition is a purified product extracted and purified from seven white formulas consisting of the following seven raw materials: 82 parts of angelica dahurica, 82 parts of bighead atractylodes rhizome, 82 parts of Japanese ampelopsis, 82 parts of white poria, 82 parts of cortex dictamni, 82 parts of rhizoma typhonii and 8 parts of pearl. The pearl is a white pearl crushed to 500-600 meshes.
The preparation method of the antibacterial skin-care traditional Chinese medicine composition comprises the following steps:
(1) extraction of
Weighing 82 parts of angelica dahurica, 82 parts of bighead atractylodes rhizome, 82 parts of ampelopsis japonica, 82 parts of poria cocos, 82 parts of cortex dictamni and 82 parts of rhizoma typhonii by weight, adding deionized water for decocting, extracting for 2 times, wherein the water amount added for the first time is 8 times of the total weight of the six components, decocting for 1 hour, the water amount added for the second time is 8 times of the total weight of the six components, decocting for 0.5 hour, filtering, combining filtrates, and concentrating to 1g crude drug/mL at normal pressure for later use;
(2) purification of
Adding 2 times of ethanol into the water extract concentrated solution obtained in the step (1), stirring while adding, standing for 12 hours, separating supernatant, concentrating under reduced pressure until no ethanol smell exists, concentrating under reduced pressure at 60 ℃ to 1g crude drug/ml, adding 8 parts by weight of pearl, and mixing thoroughly.
Example 2
An antibacterial skin-care traditional Chinese medicine composition is a purified product extracted and purified from seven white formulas consisting of the following seven raw materials: 60 parts of angelica dahurica, 60 parts of bighead atractylodes rhizome, 60 parts of Japanese ampelopsis, 60 parts of white poria, 60 parts of cortex dictamni, 60 parts of rhizoma typhonii and 6 parts of pearl. The pearl is a white pearl crushed to 500-600 meshes.
The preparation method of the antibacterial skin-care traditional Chinese medicine composition comprises the following steps:
(1) extraction of
Weighing six components of 60 parts by weight of angelica dahurica, 60 parts by weight of bighead atractylodes rhizome, 60 parts by weight of ampelopsis japonica, 60 parts by weight of poria cocos, 60 parts by weight of cortex dictamni and 60 parts by weight of rhizoma typhonii, adding deionized water for decocting for 2 times, wherein the water amount added for the first time is 6-10 times of the total weight of the six components, the decoction is carried out for 0.5 hour, the water amount added for the second time is 6 times of the total weight of the six components, the decoction is carried out for 0.1 hour, filtering, combining filtrates, and concentrating to 0.5g crude drug/mL under normal pressure for later use;
(2) purification of
Adding 1 weight time of ethanol into the water extract concentrate obtained in the step (1), stirring while adding, standing for 10 hours, separating supernatant, concentrating under reduced pressure until no alcohol smell exists, concentrating under reduced pressure at 50 ℃ to 0.5g crude drug/ml, adding 6 weight parts of pearl, and mixing thoroughly to obtain the final product.
Example 3
An antibacterial skin-care traditional Chinese medicine composition is a purified product extracted and purified from seven white formulas consisting of the following seven raw materials: 100 parts of angelica dahurica, 100 parts of bighead atractylodes rhizome, 100 parts of ampelopsis japonica, 100 parts of poria cocos, 100 parts of cortex dictamni, 100 parts of rhizoma typhonii and 10 parts of pearl. The pearl is a white pearl crushed to 500-600 meshes.
The preparation method of the antibacterial skin-care traditional Chinese medicine composition comprises the following steps:
(1) extraction of
Weighing six components of 100 parts by weight of angelica dahurica, 100 parts by weight of bighead atractylodes rhizome, 100 parts by weight of ampelopsis japonica, 100 parts by weight of poria cocos, 100 parts by weight of cortex dictamni and 100 parts by weight of rhizoma typhonii, adding deionized water for decocting for 2 times, wherein the water amount added for the first time is 10 times of the total weight of the six components, decocting for 2 hours, the water amount added for the second time is 10 times of the total weight of the six components, decocting for 1 hour, filtering, combining filtrates, and concentrating to 2g crude drugs/mL at normal pressure for later use;
(2) purification of
Adding 3 times of ethanol into the water extract concentrated solution obtained in the step (1), stirring while adding, standing for 15 hours, separating supernatant, concentrating under reduced pressure until no ethanol smell exists, concentrating under reduced pressure at 80 ℃ to 2g crude drug/ml, adding 10 parts by weight of pearl, and mixing thoroughly.
Example 4
An antibacterial skin-care traditional Chinese medicine composition is a purified product extracted and purified from seven white formulas consisting of the following seven raw materials: 80 parts of angelica dahurica, 80 parts of bighead atractylodes rhizome, 80 parts of ampelopsis japonica, 80 parts of poria cocos, 80 parts of cortex dictamni, 80 parts of rhizoma typhonii and 8 parts of pearl. The pearl is a white pearl crushed to 500-600 meshes.
The preparation method of the antibacterial skin-care traditional Chinese medicine composition comprises the following steps:
(1) extraction of
Weighing 80 parts of angelica dahurica, 80 parts of bighead atractylodes rhizome, 80 parts of ampelopsis japonica, 80 parts of poria cocos, 80 parts of cortex dictamni and 80 parts of rhizoma typhonii according to parts by weight, adding deionized water for decocting, extracting for 2 times, adding water 7 times of the total weight of the six components for the first time, decocting for 0.8 hour, adding water 7 times of the total weight of the six components for the second time, decocting for 0.6 hour, filtering, combining filtrates, and concentrating to 0.8g crude drug/mL at normal pressure for later use;
(2) purification of
Adding 1.5 times of ethanol into the water extract concentrate obtained in step (1), stirring while adding, standing for 11 hr, separating supernatant, concentrating under reduced pressure until no ethanol smell exists, concentrating under reduced pressure at 55 deg.C to 0.6g crude drug/ml, adding 8 weight parts of Margarita, and mixing thoroughly.
Example 5
An antibacterial skin-care traditional Chinese medicine composition is a purified product extracted and purified from seven white formulas consisting of the following seven raw materials: 85 parts of angelica dahurica, 85 parts of bighead atractylodes rhizome, 85 parts of Japanese ampelopsis, 85 parts of white poria, 85 parts of cortex dictamni, 85 parts of rhizoma typhonii and 9 parts of pearl. The pearl is a white pearl crushed to 500-600 meshes.
The preparation method of the antibacterial skin-care traditional Chinese medicine composition comprises the following steps:
(1) extraction of
Weighing six components, namely 85 parts of angelica dahurica, 85 parts of bighead atractylodes rhizome, 85 parts of Japanese ampelopsis, 85 parts of poria cocos, 85 parts of cortex dictamni and 85 parts of rhizoma typhonii according to parts by weight, adding deionized water for decocting, extracting for 2 times, adding water for the first time which is 9 times of the total weight of the six components, decocting for 1.5 hours, adding water for the second time which is 9 times of the total weight of the six components, decocting for 0.6 hour, filtering, combining filtrates, and concentrating to 1.5g crude drug/mL at normal pressure for later use;
(2) purification of
Adding 2.5 times of ethanol into the water extract concentrate obtained in the step (1), stirring while adding, standing for 14 hours, separating supernatant, concentrating under reduced pressure until no ethanol smell exists, concentrating under reduced pressure at 75 ℃ to 1.5g crude drug/ml, adding 9 parts by weight of pearl, and mixing thoroughly to obtain the final product.
Control group: dermatitis treating medicine
The Chinese medicinal compositions prepared in examples 1 to 5 were subjected to the following test experiments to test their properties:
1. sterilizing and itching relieving performance
(1) Influence on itch caused by histamine phosphate
50 Kunming mice with weight of 20 +/-2 g and half each male and female were randomly divided into 5 groups, and the compositions obtained in examples 1 to 5 were tested by using models
The skin of the right hind paw of the mouse was polished with fine sandpaper, 0.02% histamine phosphate 0.1mL was dropped on the polished skin to the extent that the skin became red and bled without bleeding, and the number of times and duration of itching of the mouse within 15min were immediately observed and recorded. The spasmolytic indication is that the mouse returns to lick and gnaw the back and instep skin; the interval of the pruritus duration time is more than 3 seconds and is recorded as two pruritus, and the interval of the pruritus duration time is less than 3 seconds and is recorded as one pruritus. Immediately after molding, the composition prepared in each example was uniformly applied to the skin of the right hind paw of a mouse and gently rubbed for a moment, and the number and duration of itching of the mouse were observed and recorded within 15min, and the results are shown in table 1.
TABLE 1 antipruritic effect on histamine phosphate-induced pruritus
| Number of animals | Number of itching (times) | Duration (min) | |
| Example 1 | 10 | 10.2 | 100.1 |
| Example 2 | 10 | 13.3 | 110.2 |
| Example 3 | 10 | 12.5 | 109.4 |
| Example 4 | 10 | 11.4 | 105.5 |
| Example 5 | 10 | 11.8 | 103.7 |
| Control group | 10 | 12.6 | 105.3 |
The results show that the antipruritic cream has a remarkable antipruritic effect when being smeared on the skin of a pruritus model mouse, the effect is close to that of a positive drug control group, and the antipruritic effect is exact.
2. Sterilizing effect of medicated soap
Taking 10g of the composition obtained in each of examples 1-5, fully dissolving the composition in 50mL of double distilled water to serve as a test sample, immediately carrying out bacteriostasis and sterilization determination experiments, determining by a bacteriostasis zone size determination method and a gradient dilution sterilization method, wherein a strain is staphylococcus aureus, a blank control group adopts normal saline as the test sample, each group is carried out for three times, and the diameter of the bacteriostasis zone and the minimum sterilization concentration are determined, wherein the results are shown in Table 2:
TABLE 2 bacteriostatic effect
The result shows that the invention has excellent sterilization and bacteriostasis capability, and the minimum sterilization concentration is obviously lower than that of a control group.
3. Whitening and freckle removing effects
The test method comprises the following steps: any product (cosmetic or topical medicine) cannot be used 2 days before the test site is measured. Before the test, the testee needs to uniformly clean the face and wipe the face clean with dry facial tissue. After cleaning, the measurement area is marked on the face of the subject. Standing in room with room temperature of 25 deg.C and humidity of 45% for at least 30min before formal test, and standing in test state to keep relaxed.
Face marker 3X 3cm in experiment2The test area can simultaneously mark a plurality of areas, and the areas are spaced by 3 cm. In this example 6 areas were marked and the facial test areas before and after dosing were measured using a skin melanin and heme tester, each area being measured 5 times in parallel. The blank value of each test area was measured and then the Chinese medicinal composition of the present invention was applied. The melanin content of the skin in the test area was measured after 1 week and 2 weeks, respectively. The number of the tested persons is 30, and the average value is taken
| Average melanin content | Before testing | After the film is adhered for one week | Insist on coating for two weeks |
| Example 1 | 38％ | 28％ | 20％ |
| Example 2 | 38％ | 32％ | 24％ |
| Example 3 | 38％ | 33％ | 25％ |
| Example 4 | 38％ | 30％ | 22％ |
| Example 5 | 38％ | 29％ | 21％ |
It can be seen that the traditional Chinese medicine composition can obviously play a role in whitening and lightening spots when being smeared.
4. Determination of DPPH free radical eliminating capacity and SOD superoxide dismutase antioxidation capacity
Solution preparation:
weighing respectively:
VC 27.24, 49.41 and 99.11mg are added into 50ml of water;
examples 152.03, 99.35mg constant volume to 50ml water;
examples 250.49, 100.91mg constant volume to 50ml water;
examples 349.69, 104.2mg to 50ml water;
examples 450.71, 104.35mg were made up to 50ml of water.
Examples 548.51, 103.32mg were made up to 50ml of water.
Preparing a DPPH solution:
accurately weighing 4.91mg of DPPH into a 100mL volumetric flask, and using absolute ethyl alcohol to fix the volume to obtain 49.1mg/L DPPH mother liquor.
The determination method comprises the following steps:
2.0mL of each sample solution is respectively added into a 10mL colorimetric tube, and then 2.0mL of the PPH solution is parallelly added into each colorimetric tube. Control and blank groups were set simultaneously. And (4) lightly oscillating to fully and uniformly mix the mixture, and reacting the colorimetric tube in the dark for 30min to ensure that the medicine completely reacts with the free radicals. Measured at a wavelength of 517nm and the final A value is recorded. And (4) zero setting by taking absolute ethyl alcohol as a reference. The DPPH clearance (I) for each sample was calculated according to the following formula.
I/％＝〔1－(Ai－Aj)/A0〕×100
In the formula A0Absorbance of unpelled DPPH (2.0mL DPPH +2.0mL solvent), absorbance of Ai after reaction of sample with DPPH, and absorbance of Aj for sample blank (2.0mL95 ethanol +2.0mL sample). To reduce experimental error, 3-6 cuvettes were averaged for each sample.
Results of the experiment
The traditional Chinese medicine composition has good antioxidant effect.
The antibacterial skin-care traditional Chinese medicine combined seven-ingredient formula can be used in cosmetics or washing products, wherein the cosmetics comprise facial cleanser, cosmetic water, essence, cream, eye cream, facial mask, hand cream, body lotion and the like, and the washing products comprise perfumed soap, medicated soap, laundry detergent and the like.
Claims (8)
1. The antibacterial skin-care traditional Chinese medicine composition is characterized by being a purified product extracted and purified from a seven-white formula consisting of the following seven raw materials, wherein the seven-white formula comprises the following components in parts by weight: 60-100 parts of angelica dahurica, 60-100 parts of bighead atractylodes rhizome, 60-100 parts of ampelopsis japonica, 60-100 parts of white poria, 60-100 parts of cortex dictamni, 60-100 parts of rhizoma typhonii and 6-10 parts of pearl.
2. The antibacterial skin-care traditional Chinese medicine composition according to claim 1, wherein the seven-ingredient prescription comprises: 80-85 parts of angelica dahurica, 80-85 parts of bighead atractylodes rhizome, 80-85 parts of ampelopsis japonica, 80-85 parts of white poria, 80-85 parts of cortex dictamni, 80-85 parts of rhizoma typhonii and 8-9 parts of pearl.
3. The antibacterial skin-care traditional Chinese medicine composition according to claim 1, wherein the pearl is a white pearl which is crushed to 500-600 meshes.
4. A method for preparing the antibacterial skin-care traditional Chinese medicine composition as claimed in any one of claims 1 to 3, which comprises the following steps:
(1) extraction of
Weighing 60-100 parts by weight of radix angelicae, 60-100 parts by weight of bighead atractylodes rhizome, 60-100 parts by weight of radix ampelopsis, 60-100 parts by weight of poria cocos, 60-100 parts by weight of cortex dictamni and 60-100 parts by weight of rhizoma typhonii, adding water for decoction, extracting for 2 times, adding water for the first time, wherein the water amount is 6-10 times of the total weight of the six components, decocting for 0.5-2 hours, adding water for the second time, wherein the water amount is 6-10 times of the total weight of the six components, decocting for 0.1-1 hour, filtering, combining filtrates, and concentrating to 0.5-2 g crude drug/mL at normal pressure for later use;
(2) purification of
Adding ethanol with the weight being 1-3 times that of the water extract concentrated solution obtained in the step (1), stirring while adding, standing for 10-15 hours, separating supernatant, concentrating under reduced pressure until no alcohol smell exists, concentrating under reduced pressure at 50-80 ℃ to 0.5-2 g crude drug/ml, adding 6-10 parts by weight of pearl, and fully mixing.
5. The method for preparing the antibacterial skin-care traditional Chinese medicine composition according to claim 4, wherein the water added in the step (1) is deionized water.
6. The preparation method of the antibacterial skin-care traditional Chinese medicine composition according to claim 4, wherein the composition product obtained in the step (2) contains 0.1-1 wt% of saponin and 0.1-1 wt% of glucoside.
7. The preparation method of the antibacterial skin-care traditional Chinese medicine composition according to claim 4, wherein the composition product obtained in the step (2) contains 0.1-1 wt% of SOD (superoxide dismutase) components, and the SOD components comprise three trace elements of manganese, copper and zinc.
8. The application of the antibacterial skin-care traditional Chinese medicine composition as claimed in any one of claims 1 to 3, wherein the traditional Chinese medicine composition is used in cosmetics or washing products, the cosmetics comprise facial cleanser, cosmetic water, essence, cream, eye cream, facial mask, hand cream and body milk, and the washing products comprise perfumed soap, medicated soap and laundry detergent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911189605.9A CN110787119A (en) | 2019-11-28 | 2019-11-28 | Antibacterial skin-care traditional Chinese medicine composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201911189605.9A CN110787119A (en) | 2019-11-28 | 2019-11-28 | Antibacterial skin-care traditional Chinese medicine composition and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110787119A true CN110787119A (en) | 2020-02-14 |
Family
ID=69446605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201911189605.9A Pending CN110787119A (en) | 2019-11-28 | 2019-11-28 | Antibacterial skin-care traditional Chinese medicine composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN110787119A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116753A (en) * | 2021-04-23 | 2021-07-16 | 厦门力嘉诚生物科技有限公司 | Rose essential oil face cream and preparation method thereof |
| CN114259436A (en) * | 2021-11-29 | 2022-04-01 | 澳宝化妆品（惠州）有限公司 | Double-layer cleaning composition and preparation method thereof |
| WO2024109386A1 (en) * | 2022-11-24 | 2024-05-30 | 上海家化联合股份有限公司 | Skin whitening composition capable of promoting permeation and enhancing effects |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773464A (en) * | 2009-01-09 | 2010-07-14 | 苏州知微堂生物科技有限公司 | Nano whitening anti-wrinkle speckle-removing blain-removing formula and production method thereof |
| CN105287345A (en) * | 2015-11-30 | 2016-02-03 | 冯健韬 | Multifunctional traditional Chinese medicine facial mask |
-
2019
- 2019-11-28 CN CN201911189605.9A patent/CN110787119A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773464A (en) * | 2009-01-09 | 2010-07-14 | 苏州知微堂生物科技有限公司 | Nano whitening anti-wrinkle speckle-removing blain-removing formula and production method thereof |
| CN105287345A (en) * | 2015-11-30 | 2016-02-03 | 冯健韬 | Multifunctional traditional Chinese medicine facial mask |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113116753A (en) * | 2021-04-23 | 2021-07-16 | 厦门力嘉诚生物科技有限公司 | Rose essential oil face cream and preparation method thereof |
| CN113116753B (en) * | 2021-04-23 | 2022-06-03 | 厦门力嘉诚生物科技有限公司 | Rose essential oil face cream and preparation method thereof |
| CN114259436A (en) * | 2021-11-29 | 2022-04-01 | 澳宝化妆品（惠州）有限公司 | Double-layer cleaning composition and preparation method thereof |
| CN114259436B (en) * | 2021-11-29 | 2023-11-17 | 澳宝化妆品（惠州）有限公司 | Double-layer cleaning composition and preparation method thereof |
| WO2024109386A1 (en) * | 2022-11-24 | 2024-05-30 | 上海家化联合股份有限公司 | Skin whitening composition capable of promoting permeation and enhancing effects |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101478945B1 (en) | Shampoo composition containing native plant extracts and natural oriental material extracts | |
| KR101743197B1 (en) | The manufacturing method of shampoo composition for caring scalp and promoting hair growth, and shampoo composition thereof | |
| GB2459121A (en) | A product for topical administration | |
| KR100564108B1 (en) | Cosmetic composition containing a mixed plant extract having an anti-aging effect | |
| CN110787119A (en) | Antibacterial skin-care traditional Chinese medicine composition and preparation method and application thereof | |
| KR20170137544A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| KR102086687B1 (en) | A yellow cosmetic composition for improving skin wrinkles comprising an active ingredient of a plant complex extract | |
| KR101332215B1 (en) | Cosmetic composition containing fermentated complex of extracts with cryptomeria japonica and nelumbo nucifera for acne improvement and enhancing immune system | |
| CN105939703B (en) | Shampoo composite containing indigenous plant and Chinese herbal medicine extract | |
| CN109303724A (en) | A kind of novel maintenance stoste composition of releiving containing folium artemisiae argyi | |
| CN103666868A (en) | Antiseptic and anti-inflammation moisturizing soap containing functional component | |
| CN109939193A (en) | A kind of composition for treating skin eczema, preparation and preparation method and application | |
| KR101189989B1 (en) | Cosmetic composition containing a sentence-like extract as an active ingredient | |
| CN104974867A (en) | Facial soap capable of controlling oil | |
| CN106137875B (en) | A kind of composition and facial mask | |
| CN108938511B (en) | Composition of natural plant extracts and application of composition in skin moisturizing and acne removing products | |
| CN110664671B (en) | Plant extract composition and application thereof in sunscreen, after-sun repair, photoaging prevention and whitening cosmetics | |
| KR20170136912A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| CN117482014A (en) | Purely natural plant oil control astringent composition and application thereof | |
| KR20120043254A (en) | Cosmetic pack composition containing jeju scoria powder | |
| KR20170136913A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| KR20170136911A (en) | Composition for improving skin condition comprising herb extracts mixture | |
| CN109771358A (en) | A kind of cosmetics and preparation method thereof for anti-acne | |
| KR20160003920A (en) | Cosmetic composition for anti-inflammation or improving skin trouble containing herb extracts | |
| CN103920124B (en) | A kind of bactericidal skin care ointment for frostbite |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200214 |
|
| RJ01 | Rejection of invention patent application after publication |