CN109939193A - A kind of composition for treating skin eczema, preparation and preparation method and application - Google Patents
A kind of composition for treating skin eczema, preparation and preparation method and application Download PDFInfo
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- CN109939193A CN109939193A CN201910335955.5A CN201910335955A CN109939193A CN 109939193 A CN109939193 A CN 109939193A CN 201910335955 A CN201910335955 A CN 201910335955A CN 109939193 A CN109939193 A CN 109939193A
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- eczema
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Abstract
The invention discloses a kind of compositions for treating skin eczema, including component B and component C: by weight, component B is included at least: 3~7 parts of quinine fungus extract, 5~10 parts of snail secretion filtrate, 0.1~2 part of AQUAXYL xylitol, 0.1~2 part of moisturizer；Component C is included at least: two split 5~10 parts of yeast tunning filtrate, 0.1~2 part of Chinese medical extract.The composition and its preparation of dermatitis and eczema in the present invention have significant treatment and improvement to the skin eczema disease of each age group, two split yeast product filtrate and have removing pattogenic heat from the blood and toxic material from the body used in wherein, the traditional Chinese medicine ingredients of anti-inflammatory anti-itch combine, it can be uniformly applied to the eczema position of skin, to fully absorb drug, make local vasoconstriction, hyperemia is reduced, inflammatory reaction mitigates, thus the symptom for the treatment of or alleviation eczema；In addition, the present invention is alternatively arranged as bright color, replenishing water and preserving moisture, anti-oxidant, anti-aging cosmetics in practical applications.
Description
Technical field
The present invention relates to medicine adornment field more particularly to a kind of composition for treating skin eczema, preparation and preparation method and
Using.
Background technique
Eczema is a kind of pruritus dermatopathy as caused by a variety of internal and external factors, has obvious exudation tendency, is that inflammatory is anti-
Answering property disease.It is mainly characterized in that fash be symmetric, multiform damage, recurrent exerbation, easily at chronic and violent itch
Deng being clinically divided into three phase of chronic phase, subacute stage and acute stage.Less serious case's local skin erythema, papule, there is secretion infiltration
Out；For severe one with rotten to the corn itch for main recurrent exerbation, obstinate seriously affects the health and psychology confidence of people.
Currently, clinical multi-purpose corticosteroid hormone and the compound preparation treatment eczema added with antibacterials, but make for a long time
With can produce dependence and various adverse reactions, such as atrophoderma, telangiectasis, pigmentation.If continuous external application
Corticosteroid hormone, overlong time, area is excessive, will seriously affect the health and growth and development of people.
The Chinese medicine principle of reatment of eczema be will by Shi Re Bing Pian surname dissipate that drug gathers inside and outside, exclude, adjust simultaneously
The constitution of section human body tends to be gentle, and viscera function is allowed to restore normal.The main method of use includes invigorating the spleen, dampness elimination, promoting blood circulation, rushes down clearly
Deng depending on the constitution of patient.The method that the Chinese medicine treatment of eczema generally uses Chinese medicine.Chinese medicine internal therapy is that treatment is wet
The traditional classical method of rash, this method carry out diagnosis and treatment in conjunction with the individual difference of patient from the form of local skin lesion,
The viscera function for adjusting body, to achieve the purpose that healing.And controlling drug outside not only can guide drugs to illness station through skin, send out
Local therapeutic effect is waved, and can also go deep into internal organs by flesh natural fibre line of meat hair key and play the role of Chinese medicine.
Based on the above reasons and according to classical ancient prescription, in conjunction with modern pharmacology research and clinical practice as a result, we select
With restrain, dry, the Chinese herb compound of anti-inflammatory, antiallergy, bacteriostasis combines modern some anti-inflammatory active components, group
At the composition that can treat dermatitis and eczema.
Summary of the invention
In order to solve the above-mentioned technical problem, the first aspect of the present invention provides a kind of composition for treating skin eczema,
Including component B and component C:
By weight, the component B includes at least following component: 3~7 parts of quinine fungus extract, snail secretion
5~10 parts of object filtrate, 0.1~2 part of AQUAXYL xylitol, 0.1~2 part of moisturizer；
By weight, the component C includes at least following component: two split 5~10 parts of yeast tunning filtrate, Chinese medicine
0.1~2 part of extract.
As a kind of perferred technical scheme, the moisturizer be selected from 1,3-BDO, 1,2- hexylene glycol, glycerol, panthenol,
One of Sodium Hyaluronate, propylene glycol, sorbierite, polyethylene glycol or a variety of combinations.
As a kind of perferred technical scheme, the Chinese medical extract be selected from Gotu Kola P.E, Herba Violae extract,
Dandelion extract, Cortex Phellodendri extract, nutgall extractive, kuh-seng root extract, cnidium monnieri seed extract, coptis root are extracted
Object, sorrel root extract, shaggy-fruited dittany root bark extract, Atractylis chinensis extract, radix stemonae sessilifoliae extract, garden burnet root extract,
One of summer cypress berry extract, honeysuckle flower extract, golden yellow camomile extract, borneol, purslane extract are a variety of
Mixing.
The second aspect of the present invention provides a kind of preparation for treating skin eczema, is by above-mentioned treatment skin eczema
What composition was prepared, the dosage form of preparation is one of liquid, lotion, white shape, paste.
As a kind of perferred technical scheme, the preparation of above-mentioned treatment skin eczema further includes component A and component D；
By weight, the component A includes at least following component: 0.01~0.1 part of EDTA- disodium, 1,3-BDO 3
~10 parts, 0.01~0.05 part of arginine, 5~15 parts of plant hydrosol, 50~80 parts of water；
By weight, the component D is 0.4~0.6 part of solubilizer.
As a kind of perferred technical scheme, the plant hydrosol be selected from flores aurantii hydrosol, tea tree hydrosol, pot marigold hydrosol,
One of witch hazel hydrosol, lavender hydrosol, rose or a variety of mixing.
As a kind of perferred technical scheme, it is poly- to be selected from oleth -12, oleth -15, oleyl alcohol for the solubilizer
One of ether -20 or a variety of mixing.
As a kind of perferred technical scheme, the weight of the oleth -12, oleth -15, oleth -20
Than for 1:(1~5): (3~8).
The third aspect of the present invention provides a kind of preparation method of the preparation of above-mentioned treatment skin eczema, including following step
It is rapid:
A. the material of tetra- components of A, B, C, D is accurately weighed；
B. material in component A is put into emulsion pot, stir and is warming up to 80~90 DEG C, obtain homogeneous solution, heat preservation 10~
After twenty minutes, cool down；
When being c. cooled to 41~50 DEG C, it is complete to sequentially add component B, component C and component D, stirring and dissolving；
When being d. cooled to 40 DEG C, inspection is sampled, is discharged after qualified with 200 mesh filter-cloth filterings, sealing, which is placed, to be saved, to micro- life
After analyte detection is qualified, filling finished product.
The fourth aspect of the present invention provides the application of the composition of above-mentioned treatment skin eczema, is used to treat skin wet
Rash.
The utility model has the advantages that the present invention provides a kind of composition of dermatitis and eczema and its preparations to the skin eczema of each age group
Disease has significant treatment and improvement, wherein used two split yeast product filtrate and have removing pattogenic heat from the blood and toxic material from the body, anti-inflammatory stops
The traditional Chinese medicine ingredients itched combine, and the eczema position that can be uniformly applied to skin receives local vascular to fully absorb drug
Contracting, hyperemia are reduced, and inflammatory reaction mitigates, to treat or alleviate the symptom of eczema；In addition, the present invention may be used also in practical applications
As bright color, replenishing water and preserving moisture, anti-oxidant, anti-aging cosmetics.
Detailed description of the invention
In order to further explain a kind of composition for treating skin eczema provided in the present invention, preparation and its preparation
The beneficial effect of methods and applications provides corresponding attached drawing, it is pointed out that attached drawing provided in the present invention is only all
The individual examples elected in attached drawing, purpose are also not as limitations on the claims, all by provided herein
Other corresponding maps that attached drawing obtains are it is believed that within the scope of the application protection.
Fig. 1 is the effect that the embodiment of the present application 1 is used to treat skin eczema caused by Kathon CG, and left figure is to use preceding effect,
Right figure is the effect smeared after sample half an hour；
Fig. 2 is the effect that the embodiment of the present application 2 is used to treat skin of face eczema, and left figure is to use preceding effect, and middle figure is
Using effect two days later, right figure is to use the effect after five days.
Specific embodiment
In conjunction with preferred implementation method of the invention below detailed description and including embodiment can be further understood that this hair
Bright content.Unless otherwise indicated, all technologies used herein and scientific term all have general with the application fields
Logical technical staff's is generally understood identical meaning.If mentioned in the definition and the application of the concrete term disclosed in the prior art
Any definition supplied is inconsistent, then term provided herein of being subject to defines.
It is used in the present context, unless being clearly dictated in context, otherwise without the spy of the single plural form of restriction
Sign is also intended to the feature including plural form.It will also be appreciated that term as used herein " by ... preparation " it is synonymous with "comprising",
" comprising ", " including ", " having ", "comprising" and/or " including " indicate stated group when used in this manual
Object, step, method, product or device are closed, but does not preclude the presence or addition of one or more of the other composition, step, method, system
Product or device.In addition, using " preferred ", " preferably ", " preferred " etc. to be when describing presently filed embodiment
Refer to, can provide the embodiment of the present invention of certain beneficial effects in some cases.However, under identical circumstances or other feelings
Under condition, other embodiments are also likely to be preferred.In addition to this, not dark to the statement of one or more preferred embodiments
Show that other embodiments are unavailable, is also not intended to exclude other embodiments except the scope of the present invention.
In order to solve the above-mentioned technical problem, the first aspect of the present invention provides a kind of composition for treating skin eczema,
Including component B and component C:
By weight, the component B includes at least following component: 3~7 parts of quinine fungus extract, snail secretion
5~10 parts of object filtrate, 0.1~2 part of AQUAXYL xylitol, 0.1~2 part of moisturizer；
By weight, the component C includes at least following component: two split 5~10 parts of yeast tunning filtrate, Chinese medicine
0.1~2 part of extract.
In some preferred embodiments, by weight, the component B includes at least following component: medicinal layer hole
5 parts of fungus extract, 7 parts of snail secretion filtrate, 1 part of AQUAXYL xylitol, 0.6 part of moisturizer.
In some preferred embodiments, by weight, the component C includes at least following component: two split yeast
8 parts of tunning filtrate, 0.25~0.4 part of Chinese medical extract.
Quinine fungus extract
Quinine fungus, the entitled Fomes officinalis of English, is a kind of medicinal mushroom for being grown on Eastern Europe, mentions
It takes object to be able to solve the excessive secretion of skin oil and fat, has and reduce pore, compact skin and moisture-keeping efficacy.
Quinine fungus extract in the application is produced by German BASF, the entitled KLARICYL SL8865 of board.
Snail secretion filtrate
Snail secretion, containing natural collagen, elastin, allantoin, glucuronic acid, multivitamin etc..This
Nutrition contained by a little ingredients is brought into skin deep layer, can repair skin, can increase the nutrition of skin；Allantoin can supplement carefully
Born of the same parents' regeneration factor can make skin rapid regeneration, and then restore the soft, smooth, fine and smooth of skin.Snail secretion filtrate is being controlled
More burned skin and the big scarred skin of processing and equally there is significant function in terms of the nursing of skin the pigmentation the problems such as
Effect.
Snail secretion filtrate in the application is produced by the bright moral of South Korea hundred.
AQUAXYL xylitol
AQUAXYL is a kind of active constituent of natural botanical source, and main component includes xylitol glucoside, xylose
The substances such as alcohol, anhydro xylitol, being capable of moisturizing and reconstruction skin texture system, promotion hyaluronic acid and content of chondroitin sulfate increasing
Add, improve the moisture content of epidermis and corium, promote ceramide synthesis, reinforces skin barrier effect, improve skin texture, subtract
Few water loss.
AQUAXYL xylitol in the application is by France's match Bick production.
Moisturizer
Moisturizer, mostly hydroaropic substance have moisturizing effect, and the hydrone in cosmetics can be brought by being applied on skin
Skin moisturizing immediately it is dry can to reduce skin by the moisture in draw air, balance skin water content after being absorbed by the skin
It is dry.
In some preferred embodiments, the moisturizer be selected from 1,3-BDO, 1,2- hexylene glycol, glycerol, panthenol,
One of Sodium Hyaluronate, propylene glycol, sorbierite, polyethylene glycol or a variety of combinations；It is further preferred that the moisturizer
For 1,2- hexylene glycol and Sodium Hyaluronate.
In some preferred embodiments, the weight ratio of 1, the 2- hexylene glycol and Sodium Hyaluronate is 5:1.
1,2- hexylene glycol belongs to small molecule moisturizer, easily absorbs, can also promote the infiltration of other active components；Hyalomitome
Sour sodium is the sodium salt of hyaluronic acid, can increase the water retaining function of skin, repair wound and light injury, remove free radical, for this
There are also certain thickening powers in application.
1,2- hexylene glycol in the application by German moral fragrant production；Sodium Hyaluronate is produced by the prosperous Fu Ruida of China, board name
For nano HA.
Two split yeast tunning filtrate
Two split yeast tunning filtrate or two split the molten spore object of yeast tunning, wherein containing vitamin B groups, mine
Substance, amino acid etc. are a kind of high-quality yeast essence that can be used for skin care, can reinforce cuticula beneficial to the small molecule of skin care
Metabolism, moreover it is possible to capture free radical, inhibit the peroxidating of lipid, have the function of whitening and anti-aging.In addition, the ingredient also has
Very strong anti-immunity inhibitory activity can simultaneously promote DNA to repair, and can effectively protect skin, not by UV-induced damage, be used for
Care product after skin care, sun-proof and solarization, helps the light aging for preventing epidermis and corium.Two, which split yeast, can also make various media
Ratio replys balance, this is more advantageous to the regulation of immune system, so that the cell of repairing damage, is that skin remains full of vigor
Youthful appearance.
Two in the application split yeast tunning filtrate is produced by the bright moral of South Korea hundred.
Chinese medical extract
Chinese medicinal compound extract in the application is developed according to traditional Chinese medical theory combination clinical practice, middle medical knowledge
By thinking: eczema morbidity, mostly because examining tax intolerant to then losing its maintenance the day after tomorrow, feelings will is unsuccessful, fire-syndrome caused by the disorders of the five emotions or intemperance of taking food, more
Food " hair object ", the dysfunction of the spleen in transport, raw wet intrinsic heat, multiple because of interspaces of skin and muscles being loose, bathing is drenched with rain, and protects inconsiderate, exogenous disease rheumatism heat evil, interior foreign minister
It fights, fills in space between skin and muscles, skin of contaminating is sent out as wet sore.Eczema early stage rheumatic fever is pented up in interior, outgoing in skin, wind benefaction and
Number becomes, therefore falls ill rapidly, and progress is fast；Hot is yang pathogens, and easily saturating skin of sending out is consciously scorching hot for erythema, maculopapule；Damp and hot knot of fighting, leaching
Excessive skin, it is seen that flush swelling, water lump, erosion, sepage, violent rash are itched, or have the constitutional symptoms such as restlessness and thirst.Dampness being heavy and turbid is viscous
It is greasy, keep this disease touching refractory, easy recurrent exerbation.It is damp and hot long stagnant, or long-term infiltration mistake liquid, hematozemia impairment of yin, the raw wind of dryness-transformation, skin mistake
It supports, so plump religion is split, dry furfur, and lapse to the card of blood-deficiency and wind-dry.
The basic pathogenesis of eczema be unable to do without " wet " word, in the treatment also when manage it is wet based on.Doctor advocates not
Only medicine for oral administration wants dialectical demonstration, and externally applied drug also will be according to skin lesion performance and difference treats.External-use drug form multiplicity, preparation method are particular about,
The experience of ancients is sufficiently inherited, and combines the cognition of applicant oneself.External drug can be divided mainly into two classes；First is that heat-clearing
Eliminating dampness removing toxic substances class medicine；Second is that promoting blood circulation and cooling blood class medicine.
In some preferred embodiments, the Chinese medical extract be selected from Gotu Kola P.E, Herba Violae extract,
Dandelion extract, Cortex Phellodendri extract, nutgall extractive, kuh-seng root extract, cnidium monnieri seed extract, coptis root are extracted
Object, sorrel root extract, shaggy-fruited dittany root bark extract, Atractylis chinensis extract, radix stemonae sessilifoliae extract, garden burnet root extract,
One of summer cypress berry extract, honeysuckle flower extract, golden yellow camomile extract, borneol, purslane extract are a variety of
Mixing.
Centella
Centella, scientific name Centella Asiatica (L.) Urban is bitter, pungent, cold in nature, has clearing heat and promoting diuresis, removing toxic substances to disappear
The effect of swollen, Gotu Kola P.E, which is acted on skin, can treat skin ulcer, promote skin growth, increase local leucocyte
It is more, antibacterial anti-inflammatory.
Viola mandshurica
Viola mandshurica, scientific name Viola Philippica, bitter, micro-pungent are cold in nature, there is clearing heat and detoxicating, dampness removing, cool blood detumescence
The effect of, Herba Violae extract is acted on into skin, wherein the activity of a variety of enzymes in human body can be improved in the microelement being enriched with,
Play the role of to the synthesis of nucleic acid-protein, immunologic process, cell proliferation direct or indirect, can promote epithelial cell reparation, make
Cell division increases, and T cell increases, and activity increases, so that the immune function to organism plays regulatory role, is sent out by enzyme system
Wave the regulation and control to organism metabolism.
Dandelion
Dandelion, scientific name Taraxacum mongolicum Hand.-Mazz is sweet in flavor, cold in nature, there is clearing heat and detoxicating function
Effect, acts on skin for dandelion extract, can effectively kill bacteria antibacterial.
Cortex Phellodendri/cork tree
Cortex Phellodendri/cork tree, takes bark medicinal, and bitter is cold in nature, there is the effect of heat-clearing and damp-drying drug, detoxification sore treatment, and Cortex Phellodendri is mentioned
Object is taken to act on skin, effective component isoquinoline alkaloid therein can play antibacterial, antiulcer, promote cell proliferation, increase
The effect of strong leukocytic phagocytosis.
Chinese gall
Chinese gall, scientific name Rhus chinensis Mill is sour, puckery, cold in nature, there is the function of arrest sweating hemostasis, hygroscopic sore
Nutgall extractive is acted on skin by effect, and tannic acid therein plays the role of precipitating proteins, skin ulcer face, mucous membrane and its
After contact, tissue protein is solidified, and forms layer protecting film, astriction, and the precipitating of nerve endings protein, can
Faint anesthesia mitigates itch；In addition, nutgall extractive can also bactericidal.
Kuh-seng
Kuh-seng, bitter is cold in nature, has the effect of heat-clearing and damp-drying drug, removing toxic substances cool blood, kuh-seng root extract is acted on skin,
In a variety of alkaloids, the flavones that contain can be with sterilizing and itch-relieving.
Frutus cnidii
Frutus cnidii, scientific name Cnidium monnieri (L.) Cuss, bitter is warm-natured, there is the function of heat-clearing and damp-drying drug, dispelling wind and arresting itching
Effect, acts on skin for cnidium monnieri seed extract, can treat children's tinea, malignant sore, skin eczema, allergic dermatitis etc. extensively
Disease, Qing Dynasty's name doctor's Chen Shiduo were once said in its " this innovation volume ": " frutus cnidii, function is quite odd, inside and outside all to treat, and controls outside outstanding
It is good."
The coptis
The coptis, scientific name Coptis chinensis Franch, taste is extremely bitter, cold in nature, there is the function of heat-clearing and damp-drying drug, purging fire for removing toxin
Coptis root extract is acted on skin by effect, and the alkaloids such as jamaicin therein, coptisine can antibacterial, anti-inflammatory, antiulcer.
Rheum officinale
Rheum officinale, scientific name Rheum palmatum L., bitter is cold in nature, have clearing heat-fire, removing pattogenic heat from the blood and toxic material from the body, removing dampness through diuresis and removing jaundice function
Effect, acts on skin for sorrel root extract, wherein the free property anthraquinone contained can play antibacterial effect.
Cortex dictamni
Cortex dictamni, scientific name Cortex Dictamni is bitter, salty, cold in nature, there is the function of heat-clearing and damp-drying drug, dispelling wind and arresting itching, removing toxic substances
Effect, acts on skin for shaggy-fruited dittany root bark extract, has inhibiting effect to a variety of fungies, additionally can antiallergy.
Rhizoma atractylodis
Rhizoma atractylodis, scientific name Atractylodes Lancea (Thunb.) DC. is bitter, pungent, warm-natured, there is drying damp and strengthening spleen, wind-dispelling
Atractylis chinensis extract is acted on skin, mainly plays antibacterial disinfection by the effect of cold dispelling.
The tuber of stemona
The tuber of stemona, scientific name Stemona Japonica, sweet in flavor, bitter, slightly warm in nature have the effect of heat dissipation inducing diaphoresis, desinsection, will be upright
Radix Stemonae extract acts on skin, can anti-inflammatory anti-itch.
Garden burnet
Garden burnet, scientific name Sanguisorba officinalis L., bitter, acid are cold in nature, there is cooling blood and hemostasis, removing toxic substances sore
The effect of, garden burnet root extract is acted on into skin, swelling symptom caused by inflammation can be improved, has inhibition to make various bacteria
With.
The fruit of summer cypress
The fruit of summer cypress, scientific name Kochia scoparia (L.) Schrad., acrid flavour, hardship are cold in nature, have clearing heat and promoting diuresis, wind-dispelling to stop
Summer cypress berry extract is acted on skin by the effect of itching, and can remove the damp and hot and ailment said due to cold or exposure in skin, to reach antipruritic mesh
, and have different degrees of inhibiting effect to a variety of dermatophytes.
Honeysuckle
Honeysuckle also known as honeysuckle flowers, scientific name Lonicera japonica Thunb. is sweet in flavor, cold in nature, have it is clearing heat and detoxicating,
Honeysuckle flower extract is acted on skin by the effect of anti-inflammatory, and chlorogenic acid therein, cyanidenon glycosides isoreactivity ingredient are to a variety of causes
Germ has a stronger restraint, can also strengthen immunity, anti-inflammatory, antipyretic.
Chamomile
Chamomile, scientific name Cancrinia discoidea (Ledeb.) Poljak. is bitter, pungent, and cold nature has heat-clearing to dispel
Golden yellow camomile extract is acted on skin, can be relieved inflammation or allergic symptom, calms down the capilary of rupture by the effect of wet,
The increase of white blood cell is stimulated, and then resists bacterium, enhances immune system, in addition, it is alternatively arranged as the moist calm skin of skin care ingredient,
Promote elasticity, strengthens tissue.
Borneol
Borneol, acrid flavour, hardship, cold nature have the effect of heat-clearing dissipates poison, erosion prevention and muscle growing, and borneol is acted on skin, can heat-clearing
Purging intense heat, removing toxicity for detumescence, eliminating dampness and astringing sores, antalgesic-antipruritic.
Purslane
Purslane, scientific name Portulaca oleracea L. is sour, cold in nature, has clearing heat and promoting diuresis, removing toxicity for detumescence, promoting blood circulation to stop
Purslane extract is acted on skin by the effect of blood, and it is immune and other effects to play antibacterial, enhancing.
Bulk pharmaceutical chemicals used in the present invention can be commercially available from shop of Chinese medicines and Chinese Medicinal Materials Markets, and specification meets national Chinese medicine
Material standards of pharmacopoeia, is extracted using deionized water.
In some preferred embodiments, the Chinese medical extract is cnidium monnieri seed extract, kuh-seng root extract, cork tree
The mixing of bark extract, nutgall extractive, borneol；It is further preferred that the cnidium monnieri seed extract, radix sophorae extract
Object, Cortex Phellodendri extract, nutgall extractive, borneol weight ratio be 1:1:1:1:1.
In some preferred embodiments, the Chinese medical extract be shaggy-fruited dittany root bark extract, radix stemonae sessilifoliae extract,
The mixing of honeysuckle flower extract, purslane extract, Atractylis chinensis extract；It is further preferred that the shaggy-fruited dittany root bark extract,
Radix stemonae sessilifoliae extract, honeysuckle flower extract, purslane extract, Atractylis chinensis extract weight ratio be 1:1:1:1:1.
In some preferred embodiments, the Chinese medical extract is Gotu Kola P.E, Herba Violae extract, Pu
Public English extract, kuh-seng root extract, coptis root extract, garden burnet root extract, sorrel extract, Atractylis chinensis extract
Mixing；It is further preferred that the Gotu Kola P.E, Herba Violae extract, dandelion extract, radix sophorae extract
Object, coptis root extract, garden burnet root extract, sorrel extract, Atractylis chinensis extract weight ratio be 1:1:1:1:1:
1:1:1.
The second aspect of the present invention provides a kind of preparation for treating skin eczema, is by above-mentioned treatment skin eczema
What composition was prepared, in some preferred embodiments, the dosage form of the preparation is liquid, in lotion, white shape, paste
One kind.
In some preferred embodiments, the preparation of the treatment skin eczema further includes component A and component D；
By weight, the component A includes at least following component: 0.01~0.1 part of EDTA- disodium, 1,3-BDO 3
~10 parts, 0.01~0.05 part of arginine, 5~15 parts of plant hydrosol, 50~80 parts of water；
By weight, the component D is 0.4~0.6 part of solubilizer.
In some preferred embodiments, by weight, the component A includes at least following component: EDTA- disodium
0.03 part, 5 parts of 1,3-BDO, 0.02 part of arginine, 10 parts of plant hydrosol, 60 parts of water.
In some preferred embodiments, by weight, the component D is 0.5 part of solubilizer.
EDTA- disodium
EDTA- disodium, it is a kind of common compounding agent in chemical field that No. CAS, which is 139-33-3, and there are six match
Position atom, can with most metals formed chelate, in cosmetics add EDTA- disodium can reduce free metal from
Sub- content reduces injury of the harmful metal ion to skin to ensure that the stability of cosmetics；In addition, EDTA- disodium
Also there is certain bacteriostasis, the usage amount of a part of preservative can be reduced after addition.
EDTA- disodium in the application is produced by Dutch Aksu.
1,3-BDO
1,3-BDO, No. CAS is 107-88-0, and tasteless, good water solubility has hygroscopicity, can make small point in cosmetics
Moisture is stayed in cuticula, also can be used as cosolvent by sub- moisturizer, and quality is milder, and there are also certain bacteriostasis, belongs to makeup
Common composition in product.
1,3-BDO in the application is produced by U.S. OXEA.
Arginine
Arginine, No. CAS is 74-79-3, odorless, soluble easily in water, and skin can be promoted with cutin-softening layer by being added in cosmetics
The absorbability of skin improves moisture holding capacity, improves dry and coarse.
Arginine in the application by German moral fragrant production.
Plant hydrosol
Plant hydrosol refers to the distillation stoste generated during distillation extraction plants essential oil, ingredient be a small amount of essential oil and
The mineral nutrients such as the tannic acid and flavonoids that lack in whole water-soluble substances, especially essential oil in plant, low concentration
Characteristic be easy to be less readily available for absorption by the skin, do not stimulate mildly.
In some preferred embodiments, the plant hydrosol be selected from flores aurantii hydrosol, tea tree hydrosol, pot marigold hydrosol,
One of witch hazel hydrosol, lavender hydrosol, rose or a variety of mixing；It is further preferred that the plant hydrosol
For flores aurantii hydrosol.
Flores aurantii hydrosol, can be with Whitening, spot as one of present invention active constituent, and elimination colour of skin unevenness is obscure, enhancing
Cell viability helps cytothesis, increases skin elasticity anti-aging.Both stemness water shortage, sensitivity and mature aging skin had been can be used for
Skin has splendid convergence effect, is also adapted to the partially oily skin quality of fragile processing, sensitivity skin quality and mixing, quickly supplements skin
Skin moisture, moment make skin dynamic.
Flores aurantii hydrosol in the application is produced by hundred fragrant material Chemical Company of Guangdong.
Solubilizer
Solubilizer can increase the additive of the solubility of indissoluble object in a solvent, cosmetics are mostly heterogeneous system, solubilising
Agent can be substantially reduced surface tension as surfactant, and cosmetics is made to become character stabilization and evenly dispersed system.
In some preferred embodiments, it is poly- to be selected from oleth -12, oleth -15, oleyl alcohol for the solubilizer
One of ether -20 or a variety of mixing；It is further preferred that the solubilizer is oleth -12, oleth -15, oil
The mixing of alcohol polyethers -20.
In some preferred embodiments, the weight of the oleth -12, oleth -15, oleth -20
Than for 1:(1~5): (3~8)；It is further preferred that the weight of the oleth -12, oleth -15, oleth -20
Amount is than being 1:(2~4): (5~7)；Further, the weight of the oleth -12, oleth -15, oleth -20
Amount is than being 1:3:6.
Oleth -12, oleth -15, oleth -2 in the application are ground purchased from big thousand high and new technology in Shantou City
Study carefully centered finite company.
Oleth, also known as polyoxyethylene laurel ether or Brij92, No. CAS is 9004-98-2, is a kind of right
The nonionic surfactant of skin irritation very little, in aqueous solution unionization, has excellent stability.Containing more
In the preparation of kind active constituent, the oleth of one-component cannot achieve good solubilizing effect, it has been found that by oleyl alcohol
Preparation is added with special ratios in polyethers -12, oleth -15, oleth -20, compatible between the oleth of each model
Compatibility is good, may act on different active constituents, to increase the content of each active constituent in the formulation；Applicant expects not
It is found to ground, when preparation is applied on skin, oleth can also reduce the shielding action of skin, and active constituent is made to be easier to seep
Penetrate into the absorbability for enhancing skin into cuticula.When oleth mixture content is too low or proportion not at that time, preparation can not shape
At evenly dispersed heterogeneous system, it is also easy to produce layering, influences quality；And when oleth mixture content is excessively high or proportion is improper
When, then absorption of the skin to effective component can be reduced in use, the possible reason is the micella of oleth composition
Hamper the release of active constituent.
Yeast product filtrate is split by two in the present invention and there is removing pattogenic heat from the blood and toxic material from the body, and the traditional Chinese medicine ingredients of anti-inflammatory anti-itch combine, can
It is uniformly applied to the eczema position of skin, to fully absorb drug, makes local vasoconstriction, hyperemia is reduced, inflammatory reaction
Mitigate, treatment or the symptom for alleviating eczema.The addition of other active components, as quinine fungus extract, snail secretion are filtered
The addition of liquid, arginine, plant hydrosol, moisturizer, can with cutin-softening layer, increase moisture of skin, make drug of the invention at
Divide and be easier to play a role, while the composition and the preparation containing the composition being made to have excellent skin effect.
The third aspect of the present invention provides a kind of preparation method of the preparation of above-mentioned treatment skin eczema, including following step
It is rapid:
A. the material of tetra- components of A, B, C, D is accurately weighed；
B. material in component A is put into emulsion pot, stir and is warming up to 80~90 DEG C, obtain homogeneous solution, heat preservation 10~
After twenty minutes, cool down；
When being c. cooled to 41~50 DEG C, it is complete to sequentially add component B, component C and component D, stirring and dissolving；
When being d. cooled to 40 DEG C, inspection is sampled, is discharged after qualified with 200 mesh filter-cloth filterings, sealing, which is placed, to be saved, to micro- life
After analyte detection is qualified, filling finished product.
Embodiment
Technical solution of the present invention is described in detail by the following examples, but protection scope of the present invention is not limited to
In the embodiment.Raw material use herein is unless otherwise specified commercially available.
Embodiment 1
Embodiment 1 provides a kind of composition for treating skin eczema, including component B and component C；
By weight, the component B includes following component: 5 parts of quinine fungus extract, snail secretion filtrate 7
Part, 1 part of AQUAXYL xylitol, 0.5 part of 1,2- hexylene glycol, 0.1 part of Sodium Hyaluronate；
By weight, the component C includes following component: two split 8 parts of yeast tunning filtrate, cnidium monnieri seed extract
0.05 part, 0.05 part of kuh-seng root extract, 0.05 part of Cortex Phellodendri extract, 0.05 part of nutgall extractive, 0.05 part of borneol.
This example additionally provides a kind of preparation for treating skin eczema, further includes component A including above-mentioned component B and component C
With component D；
By weight, the component A includes following component: 0.03 part of EDTA- disodium, 5 parts of 1,3-BDO, arginine
0.02 part, 10 parts of flores aurantii hydrosol, 60 parts of water；
By weight, the component D includes 0.05 part of oleth -12,0.15 part of oleth -15,0.3 part of oleyl alcohol
Polyethers -20.
The preparation method of the preparation of above-mentioned treatment skin eczema, comprising the following steps:
A. the material of tetra- components of A, B, C, D is accurately weighed；
B. material in component A is put into emulsion pot, stir and is warming up to 85 DEG C, obtain homogeneous solution, after heat preservation 15 minutes,
Cooling；
When being c. cooled to 45 DEG C, it is complete to sequentially add component B, component C and component D, stirring and dissolving；
When being d. cooled to 40 DEG C, inspection is sampled, is discharged after qualified with 200 mesh filter-cloth filterings, sealing, which is placed, to be saved, to micro- life
After analyte detection is qualified, filling finished product.
Embodiment 2
Embodiment 2 provides a kind of composition for treating skin eczema and a kind of preparation for treating skin eczema, with reality
Apply example 1 the difference is that, by weight, the component C includes following component: two split 8 parts of yeast tunning filtrate, white
0.05 part of fresh root bark extract, 0.05 part of radix stemonae sessilifoliae extract, 0.05 part of honeysuckle flower extract, purslane extract 0.05
Part, 0.05 part of Atractylis chinensis extract.
This example additionally provides a kind of preparation method of preparation for treating skin eczema, and step is similar to Example 1.
Embodiment 3
Embodiment 3 provides a kind of composition for treating skin eczema and a kind of preparation for treating skin eczema, with reality
Apply example 1 the difference is that, by weight, the component C includes following component: two split 8 parts of yeast tunning filtrate, product
Avenge careless 0.05 part of extract, 0.05 part of Herba Violae extract, 0.05 part of dandelion extract, 0.05 part of kuh-seng root extract,
0.05 part of coptis root extract, 0.05 part of garden burnet root extract, 0.05 part of sorrel extract, Atractylis chinensis extract 0.05
Part.
This example additionally provides a kind of preparation method of preparation for treating skin eczema, and step is similar to Example 1.
Embodiment 4
Embodiment 4 provides a kind of composition for treating skin eczema and a kind of preparation for treating skin eczema, with reality
Apply example 1 the difference is that, by weight, the component B includes following component: 3 parts of quinine fungus extract, snail point
5 parts of secretion filtrate, 0.1 part of AQUAXYL xylitol, 0.1 part of 1,2- hexylene glycol, 0.02 part of Sodium Hyaluronate；By weight, institute
Stating component C includes following component: two split 5 parts of yeast tunning filtrate, 0.02 part of cnidium monnieri seed extract, kuh-seng root extract
0.02 part, 0.02 part of Cortex Phellodendri extract, 0.02 part of nutgall extractive, 0.02 part of borneol.
This example additionally provides a kind of preparation method of preparation for treating skin eczema, and step is similar to Example 1.
Embodiment 5
Embodiment 5 provides a kind of composition for treating skin eczema and a kind of preparation for treating skin eczema, with reality
Apply example 1 the difference is that, by weight, the component B includes following component: 7 parts of quinine fungus extract, snail point
10 parts of secretion filtrate, 2 parts of AQUAXYL xylitol, 1.5 parts of 1,2- hexylene glycol, 0.3 part of Sodium Hyaluronate；By weight, described
Component C includes following component: two split 10 parts of yeast tunning filtrate, 0.4 part of cnidium monnieri seed extract, kuh-seng root extract 0.4
Part, 0.4 part of Cortex Phellodendri extract, 0.4 part of nutgall extractive, 0.4 part of borneol.
This example additionally provides a kind of preparation method of preparation for treating skin eczema, and step is similar to Example 1.
Embodiment 6
Embodiment 6 provides a kind of composition for treating skin eczema and a kind of preparation for treating skin eczema, with reality
Apply example 1 the difference is that, by weight, the component D include 0.05 part of oleth -12,0.1 part of oleth -15,
0.25 part of oleth -20.
This example additionally provides a kind of preparation method of preparation for treating skin eczema, and step is similar to Example 1.
Embodiment 7
Embodiment 7 provides a kind of composition for treating skin eczema and a kind of preparation for treating skin eczema, with reality
Apply example 1 the difference is that, by weight, the component D include 0.05 part of oleth -12,0.2 part of oleth -15,
0.35 part of oleth -20.
This example additionally provides a kind of preparation method of preparation for treating skin eczema, and step is similar to Example 1.
Embodiment 8
Embodiment 8 provides a kind of composition for treating skin eczema and a kind of preparation for treating skin eczema, with reality
Apply example 1 the difference is that, by weight, the component D include 0.05 part of oleth -12,0.05 part of oleth -
15,0.15 part of oleth -20.
This example additionally provides a kind of preparation method of preparation for treating skin eczema, and step is similar to Example 1.
Embodiment 9
Embodiment 9 provides a kind of composition for treating skin eczema and a kind of preparation for treating skin eczema, with reality
Apply example 1 the difference is that, by weight, the component D include 0.05 part of oleth -12,0.25 part of oleth -
15,0.5 part of oleth -20.
This example additionally provides a kind of preparation method of preparation for treating skin eczema, and step is similar to Example 1.
Embodiment 10
Embodiment 10 is blank control, and difference from Example 1 is, this example is free of component C.
This example additionally provides the preparation method of blank control, and step is similar to Example 1.
Performance evaluation
1. the preparation for the treatment of skin eczema obtained to embodiment 1-10 carries out stability test, test method is centrifugation
Experiment, centrifugal speed are 3000 revs/min, and centrifugation time is 30 minutes, and test result is shown in Table 1.
1 stability test of table
| Embodiment | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 |
| Layering | It is no | It is no | It is no | It is no | It is no | It is no | It is no | It is | It is | It is no |
2. it is obtained to embodiment 1-7 treatment skin eczema preparation carry out therapeutic effect test, and with embodiment 10
Blank control comparison (embodiment 8,9 no longer carries out therapeutic effect test not by stability test).
Test method: 160 people of volunteer for suffering from skin eczema is chosen, the age is between 15-40 years old.Male 80 people, female 80
People.Male 16 people of the age between 15-20 years old, 16 people of women；Age, 28 people of male, women 24 between 21-30 years old
People, male 36 people of the age between 31-40 years old, 40 people of women.
Referring to the standard of " modern dermatopathy and venereal disease ", the skin eczema of selected volunteer meets acute, subacute or slow
The diagnosis of property eczema:
(1) acute eczema: itch is significant, has exudation to be inclined to, easy to recur；Skin lesion is with erythema, mound sore rash, water scar, erosion
It is main；
(2) subacute eczema: based on small papule, the scales of skin that peel off, incrustation, only a small number of papulo-vesicles, water scar, mild infiltration；
(3) chronic eczema: become main with pachyderma, coarse, the fresh sample of tongue fur.
Volunteer is randomly divided into 8 groups, every group of 20 people, 8 groups are compared in terms of gender, age, the course of disease and eczema,
No significant difference, every group of volunteer try out the preparation of the obtained treatment skin eczema of the same embodiment, are grouped feelings
Condition is shown in Table 2.
The grouping situation of 2 eczema treatment group of table
It is primary that volunteer respectively smears affected part in the morning, afternoon and evening daily, and gently rubs a few minutes, continuous uninterrupted using 4 weeks, and such as 4
Product can be stopped using by having fully recovered in all, determined curative effect according to therapeutic effect and be compared.
The criterion of therapeutical effect of judgement is recovery from illness respectively, effective, effective and invalid, specific standards are such as by 4 grades of criterion of therapeutical effect evaluations
Under:
(1) fully recover: skin lesion is all subsided, and pruritis disappears, total effects rate >=90%；
(2) effective: skin lesion is largely subsided, and itch is substantially reduced, 60%≤total effects rate < 90%；
(3) effectively: skin lesion partial remission, pruritis make moderate progress, 20%≤total effects rate < 60%；
(4) invalid: skin lesion is subsided unobvious, and itch has no mitigation or clinical symptoms are counter sees deterioration, total effects rate <
20%.
In terms of total effective rate adds obvious effective rate by cure rate, test result is shown in Table 3.
The test of 3 therapeutic effect of table
| Embodiment | Number of cases | Recovery from illness | It is effective | Effectively | In vain | Total effective rate |
| 1 | 20 | 13 | 6 | 0 | 1 | 95% |
| 2 | 20 | 12 | 6 | 1 | 1 | 90% |
| 3 | 20 | 10 | 7 | 1 | 2 | 85% |
| 4 | 20 | 9 | 6 | 3 | 2 | 75% |
| 5 | 20 | 12 | 7 | 1 | 0 | 95% |
| 6 | 20 | 8 | 5 | 4 | 3 | 65% |
| 7 | 20 | 7 | 6 | 5 | 2 | 65% |
| 10 | 20 | 0 | 2 | 3 | 15 | 10% |
From the point of view of test result, a kind of composition that treating skin eczema and its preparation provided by the invention are to each age group
Skin eczema disease have significant treatment and improvement, and it is environmentally protective, be free of corticosteroid hormone and antibiotic,
Therefore be not in the side effect of hormone, also there is no crossed sensitization and crossing drug resistant is led to the problem of with other antibiotic, curative effect is true
It cuts, provides effective treatment for treatment skin eczema；In addition, it has been found that the preparation containing the composition is actually being answered
There are also bright color, replenishing water and preserving moisture, diminution pore in, the effect of face's blackhead and red capillary is gone, which can be by attached drawing 2
It learns.
At last it is pointed out that the foregoing is merely illustrative of the preferred embodiments of the present invention, it is not intended to limit the invention, it is all at this
Made any modifications, equivalent replacements, and improvements etc., should be included in protection model of the invention within the spirit and principle of invention
Within enclosing.
Claims (10)
1. a kind of composition for treating skin eczema, which is characterized in that including component B and component C:
By weight, the component B includes at least following component: 3~7 parts of quinine fungus extract, the filter of snail secretion
5~10 parts of liquid, 0.1~2 part of AQUAXYL xylitol, 0.1~2 part of moisturizer；
By weight, the component C includes at least following component: two split 5~10 parts of yeast tunning filtrate, traditional Chinese medicine extraction
0.1~2 part of object.
2. the composition for the treatment of skin eczema as described in claim 1, which is characterized in that the moisturizer is selected from 1,3- fourth two
One of alcohol, 1,2- hexylene glycol, glycerol, panthenol, Sodium Hyaluronate, propylene glycol, sorbierite, polyethylene glycol or a variety of groups
It closes.
3. the composition for the treatment of skin eczema as described in claim 1, which is characterized in that the Chinese medical extract is selected from accumulated snow
Careless extract, Herba Violae extract, dandelion extract, Cortex Phellodendri extract, nutgall extractive, radix sophorae extract
It is object, cnidium monnieri seed extract, coptis root extract, sorrel root extract, shaggy-fruited dittany root bark extract, Atractylis chinensis extract, straight
Vertical Radix Stemonae extract, garden burnet root extract, summer cypress berry extract, honeysuckle flower extract, golden yellow camomile extract, borneol, horse
One of sativa extract or a variety of mixing.
4. a kind of preparation for treating skin eczema, which is characterized in that it is by treatment as claimed in any one of claims 1 to 3
What the composition of skin eczema was prepared, the dosage form of preparation is one of liquid, lotion, white shape, paste.
5. the preparation for the treatment of skin eczema as claimed in claim 4, which is characterized in that further include component A and component D；
By weight, the component A includes at least following component: 0.01~0.1 part of EDTA- disodium, 1,3-BDO 3~10
Part, 0.01~0.05 part of arginine, 5~15 parts of plant hydrosol, 50~80 parts of water；
By weight, the component D is 0.4~0.6 part of solubilizer.
6. the preparation for the treatment of skin eczema as claimed in claim 5, which is characterized in that it is pure that the plant hydrosol is selected from flores aurantii
One of dew, tea tree hydrosol, pot marigold hydrosol, witch hazel hydrosol, lavender hydrosol, rose or a variety of mixing.
7. the preparation for the treatment of skin eczema as claimed in claim 5, which is characterized in that the solubilizer is selected from oleth-
12, one of oleth -15, oleth -20 or a variety of mixing.
8. the preparation for the treatment of skin eczema as claimed in claim 7, which is characterized in that the oleth -12, oleyl alcohol are poly-
Ether -15, oleth -20 weight ratio be 1:(1~5): (3~8).
9. a kind of preparation method of the preparation for the treatment of skin eczema as claimed in claim 5, which is characterized in that including following step
It is rapid:
A. the material of tetra- components of A, B, C, D is accurately weighed；
B. material in component A is put into emulsion pot, stir and is warming up to 80~90 DEG C, obtain homogeneous solution, keep the temperature 10~20 points
Zhong Hou, cooling；
When being c. cooled to 41~50 DEG C, it is complete to sequentially add component B, component C and component D, stirring and dissolving；
When being d. cooled to 40 DEG C, inspection is sampled, is discharged after qualified with 200 mesh filter-cloth filterings, sealing, which is placed, to be saved, and is examined to microorganism
After surveying qualification, filling finished product.
10. a kind of application of the composition for the treatment of skin eczema as claimed in any one of claims 1 to 3, which is characterized in that its
For treating skin eczema.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110897987A (en) * | 2019-12-16 | 2020-03-24 | 广州熙然化妆品有限公司 | Composition for resisting wrinkles and tightening skin and application of composition in cosmetics |
| CN111249195A (en) * | 2020-02-28 | 2020-06-09 | 广州艾蓓生物科技有限公司 | Refreshing astringent lotion and preparation method thereof |
| CN114028248A (en) * | 2021-12-07 | 2022-02-11 | 上海美浮特生物科技有限公司 | Hand-washing-free skin antibacterial foam and preparation method and application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006083112A (en) * | 2004-09-17 | 2006-03-30 | Noevir Co Ltd | Skin care preparation for external use |
| CN108578465A (en) * | 2018-08-02 | 2018-09-28 | 上海凯宝药业股份有限公司 | A kind of Chinese medicine composition and its preparation method and application |
| CN109288931A (en) * | 2018-11-16 | 2019-02-01 | 上海松皓生物科技有限公司 | A kind of composition for treating infant eczema, preparation and preparation method and application |
-
2019
- 2019-04-24 CN CN201910335955.5A patent/CN109939193A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006083112A (en) * | 2004-09-17 | 2006-03-30 | Noevir Co Ltd | Skin care preparation for external use |
| CN108578465A (en) * | 2018-08-02 | 2018-09-28 | 上海凯宝药业股份有限公司 | A kind of Chinese medicine composition and its preparation method and application |
| CN109288931A (en) * | 2018-11-16 | 2019-02-01 | 上海松皓生物科技有限公司 | A kind of composition for treating infant eczema, preparation and preparation method and application |
Non-Patent Citations (4)
| Title |
|---|
| 戎茜: "动物粘液的功能与利用概述", 《生物学教学》 * |
| 李和伟，等: "从皮肤微生态角度分析化妆品中的防腐、抑菌成分对皮肤健康的影响", 《日用化学品科学》 * |
| 橙子: "植物纯露与你的芳香生活", 《中国化妆品》 * |
| 王吉星: "赛比克推出新的保湿原料", 《日用化妆品科学》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110897987A (en) * | 2019-12-16 | 2020-03-24 | 广州熙然化妆品有限公司 | Composition for resisting wrinkles and tightening skin and application of composition in cosmetics |
| CN111249195A (en) * | 2020-02-28 | 2020-06-09 | 广州艾蓓生物科技有限公司 | Refreshing astringent lotion and preparation method thereof |
| CN111249195B (en) * | 2020-02-28 | 2022-06-07 | 广州艾蓓生物科技有限公司 | Refreshing astringent lotion and preparation method thereof |
| CN114028248A (en) * | 2021-12-07 | 2022-02-11 | 上海美浮特生物科技有限公司 | Hand-washing-free skin antibacterial foam and preparation method and application thereof |
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Application publication date: 20190628 |