CN110772578A

CN110772578A - Human body immunity enhancer for preventing and treating cancer and preparation method thereof

Info

Publication number: CN110772578A
Application number: CN201911095186.2A
Authority: CN
Inventors: 李胜; 李天一; 周民强; 赵芮停
Original assignee: Individual
Current assignee: Individual
Priority date: 2019-11-11
Filing date: 2019-11-11
Publication date: 2020-02-11

Abstract

The invention discloses a human body immunity enhancer for preventing and treating cancer, which comprises the following components in parts by weight: 222 parts of echinacol, 288 parts of astragaloside 144, 177 parts of chrysin 111, 666 parts of coriolus versicolor polysaccharide 333, 22-33 parts of diindolylmethane, 60-111 parts of resveratrol, 80-111 parts of curcumin, 222 parts of dihydroquercetin 111, 222 parts of tea polyphenol 111, 2.22-11.1 parts of L-selenomethionine, 80-130 parts of phosphatidylcholine, 90-140 parts of phosphatidylserine, 888 parts of methionine 444, and 4000 parts of liposome matrix emulsion 3000-. The invention mixes the natural Chinese medicine extract compound with a plurality of active compounds according to a proportion, adopts a liposome matrix which is convenient to absorb, can improve the autoimmunity of a human body, and effectively resists cancers, AIDS and other immunodeficiency diseases.

Description

Human body immunity enhancer for preventing and treating cancer and preparation method thereof

Technical Field

The invention relates to the fields of life science and biotechnology, in particular to a human immunity enhancer for preventing and treating cancers and a preparation method thereof.

Background

The incidence of cancer is closely related to the immune system, and when the immune system of the human body is suppressed by immunodeficiency diseases, the incidence of cancer increases.

The Chinese patent with the application number of 201210090317.X discloses a traditional Chinese medicine for treating cancer, wherein the traditional Chinese medicine raw materials comprise oldenlandia diffusa, astragalus mongholicus, salvia miltiorrhiza, trichosanthes kirilowii maxim, cordyceps sinensis and ganoderma lucidum, and the medicines complement each other in strength to form the effects of tonifying qi and nourishing blood, promoting blood circulation to remove blood stasis, warming middle-jiao and dispelling cold, restoring yang and dredging collaterals, relieving swelling and resolving masses, strengthening body resistance and consolidating constitution, improving immune function and the like.

The Chinese patent application No. 201310530442.2 discloses a traditional Chinese medicine for treating cancer, which comprises rhizoma sparganii, radix sophorae tonkinensis, radix salviae miltiorrhizae, radix scrophulariae, radix adenophorae, radix codonopsis pilosulae, radix angelicae, angelica sinensis, radix paeoniae rubra, radix curcumae, radix scutellariae, poria cocos, rhizoma zedoariae, thunberg fritillary bulb, semen Impatientis, dandelion, cortex moutan, cinnabar, eupolyphaga, trogopterus dung, safflower, cordyceps sinensis, pangolin, elecampane, rhizoma corydalis, leech and lumbricus, and can eliminate cancer cells by means of self resistance of patients through improvement of immunity. The cancer patients take the medicine after operation, radiotherapy and chemotherapy to play a role in preventing relapse, and the medicine can reduce pain and prolong life for the patients with advanced cancer; the medicine is taken by early cancer patients, and also has better curative effect.

The present invention of Chinese patent application No. 02808956.1 discloses an immunopotentiator comprising a component selected from the group consisting of a mushroom-derived component and β -glucan, for example, a mushroom-derived component, particularly an extract of mushroom such as shiitake mushroom, and the like, and further comprising an ultrafine particle or a composition containing the same, which can increase the absorbability through the mucous membrane to exert the immunopotentiating and/or immunoregulatory effects thereof.

At present, traditional Chinese medicine and western medicine generally adopt symptomatic treatment on patients, and neglect that many patients have problems of human immune systems. Two immunologists were awarded with a nobel physiological or medical prize in 2018: james ellison (James p. allison) in the united states and trout hon (Tasuku Honjo) in japan, to highlight their ability to attack tumor cells by activating the body's own immune system, have invented a completely new cancer treatment principle, immunotherapy. This fundamentally changes people's opinion on cancer treatment.

Long-term clinical studies by the inventors have demonstrated that immunotherapy is a help to the human autoimmune system to combat viral diseases, as no product is more effective than the human autoimmune system to combat diseases. Because when the human immune system is suppressed by immunodeficiency diseases, the incidence of cancer increases. Children with immunodeficiency disorders have an increased chance of lymphoma, leukemia, and hodgkin's disease. HIV-positive patients are immunosuppressed by a variety of cancer types, including Kaposi's sarcoma, non-Hodgkin's lymphoma, cervical cancer, and Hodgkin's disease. The incidence of cancer is increased in organ transplant patients and patients with autoimmune diseases due to the use of immunosuppressive drugs. The present investigators have discovered that by recognizing and destroying cancer cells, the immune system plays an important role in preventing cancer. Natural herbal compounds, most of which have low toxicity and are beneficial to the whole patient, are used for treating cancer and viral diseases.

It is the very complex immune system, mainly involving the production of antibodies and cellular immunity, involving the interaction of multiple cells that process information, recognize "self" and "others", and effectively eliminate foreign invaders.

Research has found that in connection with HIV infection, we are mainly concerned with immune cells and proteins that coat the outside of the cell, which are the targets of the HIV virus. The CD4 protein is present on several cells of the immune system. The cells with the highest concentration of CD4 were called CD4+ T cells, CD8+ cells were also rich in CD4 protein, CD4+ cells were the major target cells for hiv, but all other cells displaying CD4 protein were also adversely affected. The primary function of CD4+ cells is to act as helper cells, promoting the function of many other cells of the immune system. CD8+ cells are NK cells, a natural killer cell that recognizes and destroys cells that are encapsulated by foreign proteins. They may also suppress immune responses. Initially, in acute HIV infection, the number of CD8+ cells increases with activation of the immune system. Also seriously, the number of CD8+ cells may continue to rise or return to normal levels. Apparently, due to the excessive number of virus particles, a large number of CD8+ cells disappeared, followed by a decrease in the absolute number of CD8+ T lymphocytes as the disease entered the chronic stage. CD16+/CD56+ cells are another subset of NK cells and have the function of eliminating foreign invasion. One or more of these T cell subsets may develop arrest or fail to function resulting in immunodeficiency or autoimmune disease.

Normally, the immune system is in equilibrium and becomes active when it encounters an invading organism. When the threat is cleared by the intact immune system, it returns to normal. The immune system of the viral infection is chronically activated. Prolonged exposure of the immune system to a particular viral invader may eventually result in an inability to maintain an adequate immune response to that invader. Furthermore, if the immune system is in a chronic state of activation, the ability of the immune system to respond to a wide range of viruses and other threats may be compromised.

Research summarizes that seven causes for promoting the canceration of cells are respectively 1 and the induction of genetic instability; 2. abnormal expression of the gene; 3. sensing an abnormal signal; 4. abnormal cell-to-cell communication; 5. inducing angiogenesis; 6. invasion and transfer; 7. invasion of immunity. To prevent and treat cell canceration, it is necessary to suppress these seven carcinogenic causes. Methods of inhibiting these seven causes contributing to cellular carcinogenesis: reducing genetic instability; inhibiting abnormal expression of the gene; inhibiting aberrant signal transduction; encourage normal intercellular communication; inhibiting tumor angiogenesis; inhibiting invasion and metastasis of tumors; restoring the immune system.

Studies suggest a direct relationship between insulin, estrogen, testosterone and cancer:

the proliferation of cancer cells is positively correlated with the production of insulin, sex hormones and lactic acid. When cancer cells proliferate, local inflammation and chaotic cell development occur, resulting in a hypoxic (low oxygen) environment. This local hypoxic condition results in overproduction of lactic acid and inefficient use of glucose, which in turn stimulates angiogenesis (new blood vessels) in an attempt to provide more glucose and oxygen to the area. Cancer cells consume glucose 3 to 5 times faster than normal cells. As cancer cells proliferate, blood glucose levels increase, resulting in increased serum insulin levels. Insulin has also been shown to be a growth factor in cancer cell cultures, which causes the cells to proliferate. Inhibition of the abnormal production of lactate and insulin is an important aspect of any cancer treatment.

Hormones, especially estrogen and testosterone, have been shown to be a cancer growth factor not only in reproductive organs (breast, prostate and ovarian cancer), but also in other types of cancer (pancreatic, lymphatic, skin, kidney, colon and lung). Thus, normal hormone production is an important target for cancer therapy.

Natural herbal compounds, cancer and viruses:

many natural herbal compounds have been shown to have therapeutic effects on cancer and AIDS. Clearly, those compounds with the greatest number of properties to inhibit 7 pro-cancer causes would be the most desirable and effective use. Studies have also shown that inhibition of seven proto-cancerous events also inhibits the proliferation of the HIV virus by inhibiting the viral uptake process, intercellular fusion, viral growth, viral transmission and immune stimulation.

Therefore, the invention combines the traditional medicine and the modern life science, fully exerts the advantages of low toxicity and few side effects of natural Chinese herbal medicine compounds and can enhance the vitality of an immune system, and has important significance for developing the human immunity enhancer for preventing and treating cancers.

Disclosure of Invention

In view of the defects of the existing cancer prevention and treatment medicines, the invention provides a human body immunity enhancer for cancer prevention and treatment and a preparation method thereof.

The specific technical scheme of the invention is as follows:

a human immunity enhancer for preventing and treating cancer comprises the following components in parts by weight: 222 parts of echinacol, 288 parts of astragaloside 144, 177 parts of chrysin 111, 666 parts of coriolus versicolor polysaccharide 333, 22-33 parts of diindolylmethane, 60-111 parts of resveratrol, 80-111 parts of curcumin, 222 parts of dihydroquercetin 111, 222 parts of tea polyphenol 111, 2.22-11.1 parts of L-selenomethionine, 80-130 parts of phosphatidylcholine, 90-140 parts of phosphatidylserine, 888 parts of methionine 444, and 4000 parts of liposome matrix emulsion 3000-.

Further, the human immunity enhancer for preventing and treating the cancer comprises the following components in parts by weight: 200 parts of echinacol, 240 parts of astragaloside 160, 160 parts of chrysin 120, 500 parts of coriolus versicolor polysaccharide 400, 25-30 parts of diindolylmethane, 80-105 parts of resveratrol, 90-105 parts of curcumin, 200 parts of dihydroquercetin 130, 200 parts of tea polyphenol 130, 4.5-8.5 parts of L-selenomethionine, 90-120 parts of phosphatidylcholine, 130 parts of phosphatidylserine 100, 700 parts of methionine 500 and 3600 parts of liposome matrix emulsion 3400.

Further, the human immunity enhancer for preventing and treating the cancer comprises the following components in parts by weight: 160 parts of echinacol, 180 parts of astragaloside IV, 130 parts of chrysin, 450 parts of coriolus versicolor polysaccharide, 27 parts of diindolylmethane, 90 parts of resveratrol, 95 parts of curcumin, 160 parts of dihydroquercetin, 160 parts of tea polyphenol, 6.5 parts of L-selenomethionine, 100 parts of phosphatidylcholine, 120 parts of phosphatidylserine, 600 parts of methionine and 3500 parts of liposome matrix emulsion.

A preparation method of a human body immunity enhancer for preventing and treating cancer comprises the following steps:

step one, weighing raw materials of each component in sequence according to the mass ratio;

step two, heating 3000-4000 parts of the prepared liposome matrix emulsion to 70-80 ℃, sequentially adding 80-130 parts of the weighed phosphatidylcholine, 90-140 parts of the phosphatidylserine and 888 parts of the methionine 444-minus one, stirring until the phosphatidylcholine, the phosphatidylserine and the 888 parts of the methionine are completely dissolved, and cooling to 50-60 ℃ for later use;

dissolving a corresponding amount of xanthan gum into 3000-3500 parts of pure water according to the mass fraction of 0.3%, adding a specified proportion of natural perfume, stevia, sodium benzoate and potassium sorbate, and heating to 50-60 ℃ for later use after complete dissolution;

step four, heating 3500 parts of 3000-flavored purified water to 70-80 ℃, sequentially adding 222 parts of echinacol 111-flavored, 288 parts of astragaloside 144-flavored, 177 parts of chrysin 111-flavored, 666 parts of coriolus versicolor polysaccharide 333-flavored, 22-33 parts of diindolylmethane, 60-111 parts of resveratrol, 80-111 parts of curcumin, 222 parts of dihydroquercetin 111-flavored, 222 parts of tea polyphenol 111-flavored and 2.22-11.1 parts of L-selenomethionine, uniformly stirring, and cooling to 50-60 ℃ for later use;

step five, mixing and uniformly stirring the liquid obtained in the step two, the step three and the step four to form emulsified fluid, and standing until no emulsified foam exists, thus obtaining the human body immunity enhancer for preventing and treating cancers;

and step six, filling the liquid medicine which is kept stand until no emulsified foam is formed into a 500mL high-temperature resistant glass bottle, sterilizing at high temperature, naturally cooling to room temperature, labeling, and packaging to obtain the product.

The invention combines the traditional theory of 'monarch, minister, assistant and guide' of traditional Chinese medicine with the experiment achievement of modern medicine, compounds such as polysaccharide extracted from natural Chinese herbal medicines are compounded with amino acid compounds extracted from soybean and milk, and the human immunity enhancer for preventing and treating cancer is prepared strictly according to the preparation method of the invention; secondly, the traditional Chinese medicine extracts used in the invention synergistically play the effects of promoting blood circulation to remove blood stasis, reducing swelling and resolving masses and phagocytizing tumor cells; finally, the amino acid active substance used by the invention can also discharge the endotoxin accumulated by the human body out of the body and promote the recovery of the sick body.

The astragaloside IV and the echinacea polyphenol directly act on human bone marrow, so that the human body can generate red bone marrow by self, the red bone marrow generates blood, bone marrow hematopoietic stem cells are directly generated, dormant stem cells are activated, unhealthy cells are repaired, a human body comprehensive immune system is activated, the inducement for promoting the canceration of the cells is inhibited, unhealthy tissue cells of the human body are repaired, and the human body is comprehensively conditioned; the adjuvant materials comprise Coriolus versicolor polysaccharide, diindolylmethane, resveratrol, curcumin, dihydroquercetin, and tea polyphenols, and have effects of resisting oxidation, promoting discharge of toxic substances, effectively stimulating immune system, and inhibiting invasion of cancer cells; the L-selenomethionine, the phosphatidylcholine, the phosphatidylserine and the methionine are used as adjuvants, so that the essential amino acid of a human body can be perfectly supplemented, the function of nerve cells can be improved, and the inducement for promoting the canceration of the cells can be inhibited. In addition, from the test results, the improvement of the nerve cell function is in a certain dose-effect relationship with the anticancer activity of the immunopotentiator. The liposome matrix used in the invention not only serves as a carrier to reduce the dosage of the drug, but also has anticancer effect by cooperating with the rest components, and the adopted liposome delivery system has higher cellular uptake and longer therapeutic drug circulation and plays a vital role in exerting the effect of the natural compound to the maximum extent.

The human body immunity enhancer for preventing and treating cancer of the invention also comprises water, natural perfume, stevia rebaudiana, sodium benzoate and potassium sorbate. The main component of the stevia rebaudiana is stevioside, which not only has high sweetness and low calorie, but also has certain pharmacological action, and can be cooperated with the components in the immunopotentiator to play the roles of enhancing the immunity and resisting cancer. It has the functions of treating diabetes, controlling blood sugar, lowering blood pressure, resisting tumor, resisting diarrhea, raising immunity, promoting metabolism, etc. and has excellent effects of controlling obesity, regulating gastric acid, relieving nerve fatigue, etc. it has also obvious curative effect on heart disease, infant's decayed tooth, etc. and can eliminate the side effect of cane sugar.

The human immunity enhancer for preventing and treating cancer provided by the invention is filled in a 500mL high-temperature resistant glass bottle, is convenient to carry and store, and can be directly drunk, the components are effective components extracted from natural raw materials, and compared with traditional Chinese medicine raw materials, the human immunity enhancer is easier to absorb by a human body, and can directly participate in immune system metabolism after being absorbed, so that the human immunity enhancer acts on cancer cells, inhibits 7 inducers for promoting cell canceration, enables the human autoimmune system to play a role in inhibiting the cancer cells, and achieves the effect of preventing and treating cancer.

The human immunity enhancer for cancer prevention and treatment of the present invention is intended to help the human autoimmune system resist viral diseases because no product is more effective than the human autoimmune system against diseases. Several studies have linked this formulation to successful treatment of cancer, viruses, and for general health and prophylactic defense of the immune system.

The human immunity enhancer for cancer prevention and treatment of the present invention provides nutrients and active substances necessary for the body to recover from cancer, HIV and other immunodeficiency diseases, and the action mechanism includes mobilizing killer lymphocytes to attack malignant cells, killing many harmful viruses, repairing damaged immune system (common to cancer patients), and stimulating the production of killer lymphocytes and other lymphocytes increasing antibody production. In vitro tests show that the preparation is effective on 7 cell lines in total, and clinical application results show that the preparation is also effective in treating liver cancer, kidney cancer, glioblastoma multiforme, invasive ductal carcinoma, oligodendroglia, lung cancer, small cell lung cancer, bladder cancer, colon cancer, ovarian cancer, pancreatic cancer, melanoma, sarcoma, brain tumor and the like.

The components used in the invention have the following effects and pharmacology:

echinacol: is chrysanthemum polyphenol extracted from Echinacea purpurea, also called Echinacea purpurea polyphenol. Echinacea is a family of Compositae wild flowers native to the America. The echinacea purpurea extracts have immunological activity, anti-inflammatory activity, antiviral activity and antitumor activity, and the echinacea purpurea polyphenol has pharmacological action as immunomodulator and immunostimulant, and has antiviral, antifungal, antitumor, pesticidal and antiphlogistic effects. Echinacea polyphenols stimulate non-specific defense mechanisms and attack virus-infected cells. Echinacea purpurea is recognized in the world medical field, has the only function of preserving bone marrow in nature, and is a deep immune substance for remarkably improving and maintaining the autonomous immunity. The clinical application of the medicine is far more than the existing transfer factors, interferons and the like. Discovery of "bone marrow preservation" of echinacea. It has been made a true "full recovery immunospecialist". After the echinacea purpurea is continuously taken for 3 months, the conversion rate of ruddy bone marrow reaches 29.6 percent, the treatment course is shortened by 50 percent to 200 percent, the side effect of the medicine is obviously reduced, the cure rate of the disease is improved, the effective rate is 30 percent to 270 percent, and a plurality of stubborn diseases and major diseases can be truly and radically cured. Inhibit 7 causes that contribute to cell carcinogenesis.

Astragaloside IV: is radix astragali extract. The main component of astragalus root is astragalus polysaccharide, and the effective components in astragalus polysaccharide are polysaccharide and astragaloside. The astragalosides include astragaloside I, astragaloside II and astragaloside IV. Radix astragali is a necessary medicine in traditional Chinese medicine due to the efficacy of tonifying qi and immunity, wherein the best biological activity is astragaloside IV, namely astragaloside IV. The potency of astragaloside IV is more than 2 times of that of conventional Astragalus polysaccharides, and the anticancer and antiviral effects are more than 30 times of that of Astragalus polysaccharides. Because of the low content and good effect, the super astragalus polysaccharide is called. When the astragalus and the echinacea are used together, the astragaloside IV and the echinacea polyphenol directly act on human bone marrow, so that the human body can generate red bone marrow by itself, the red bone marrow generates hematopoiesis, bone marrow hematopoietic stem cells are directly generated, dormant stem cells are activated, and unhealthy cells are repaired. Forms the work of the overall immune system of the human body, inhibits 7 causes for promoting the canceration of cells, and repairs unhealthy tissue cells of the whole system of the human body to cause the all-round conditioning of the human body.

Chrysin: is propolis bee pollen extract. The chrysin has high content in propolis, has wide pharmacological and physiological activities of oxidation resistance, tumor resistance, cancer resistance, virus resistance, hypertension resistance, diabetes resistance, bacteria resistance, allergy resistance and the like, is widely distributed in plants, has low toxicity, can enhance the cytotoxicity of Tumor Necrosis Factor (TNF) to cancer cells, inhibit abnormal hormone action, bind estrogen receptors, change steroid hormone metabolism, normalize the levels of testosterone and other androgens, inhibit the expression and invasion of HIV in cell culture, inhibit the activation of HIV-1 and show the activity of resisting HIV.

Coriolus versicolor polysaccharide: is polysaccharide extracted from Coriolus versicolor mycelium and fermentation broth. Coriolus versicolor polysaccharide has anti-tumor, immunity enhancing and liver protecting effects, and has inhibition rates of 80% and 100% for mouse sarcoma 180 and Ehrlich carcinoma, respectively, and strong cancer cell inhibiting activity. Coriolus versicolor polysaccharide has immunoregulation function, is good immunopotentiator, and has effects of enhancing immunocyte function and recognition capability, and increasing IgM amount; the Coriolus versicolor polysaccharide has liver protecting effect, can significantly reduce serum transaminase, and has obvious repairing effect on liver tissue pathological changes and liver necrosis. Coriolus versicolor polysaccharide has effects of stimulating immune system, increasing natural killer cell cytotoxicity, inhibiting cancer cell invasion (metastasis and local proliferation), inhibiting 6 of 7 causes promoting cell canceration, increasing cancer patient survival rate after chemotherapy, and providing antiviral drug for AIDS virus treatment.

Diindolylmethane: is a phytochemical extracted from vegetables of Brassicaceae (such as broccoli, cabbage, and cabbage). The application and the effect are as follows: 1. preventing breast cancer, uterine cancer and colorectal cancer; 2. preventing symptoms of prostatic hyperplasia; 3. treating premenstrual disease. Has strong antiestrogenic effect on cancer cells, and can inhibit adhesion, activity and invasiveness of cancer cells, and inhibit 5 of 7 causes promoting canceration of cells.

Resveratrol: is a mulberry extract. Resveratrol is a natural phytoestrogen. It exists mainly in the form of glycoside in nature, and after hydrolysis, glucosyl group is removed to form resveratrol aglycone. Resveratrol is an effective antioxidant which inhibits lipid peroxidation of low density lipoproteins and prevents oxidation of low density lipoproteins to produce cytotoxins, thereby protecting cells from lipid peroxidation. Resveratrol has a better antioxidant effect than antioxidants such as VC and VE because it contains very high hydrophilic and lipophilic components. The research of stimulating vascular epithelial cells by using substances such as lipopolysaccharide and the like and then acting the resveratrol on the tissue factor in the vascular cells shows that the tissue factor can be well inhibited by the research result. Additional studies have shown that resveratrol reduces platelet aggregation and thereby prevents atherosclerosis. Inhibit 6 of 7 causes that contribute to cellular carcinogenesis. Inhibition of insulin resistance, inhibition of aberrant estrogen action, resulting in anti-hiv activity: inhibit viral replication and proliferation.

Curcumin: is Curcuma rhizome extract. Turmeric is a commonly used medicine, and the main bioactive components of the turmeric are curcumin and volatile oil. Curcumin has effects of reducing blood lipid, resisting coagulation, resisting oxidation, promoting bile flow, and resisting cancer; curcumin exerts its anticancer effect by inducing differentiation of malignant tumor cells, inducing apoptosis of tumor cells and inhibiting effect on tumor growth in each stage, and has wide clinical application. Curcumin, as an effective antioxidant, has potent anti-inflammatory activity, inhibits insulin resistance, inhibits cancer cell proliferation in vitro, inhibits metastasis in vivo, and inhibits 5 of 7 causes that contribute to cell carcinogenesis. Inhibiting tat-mediated long terminal repeat activation of human immunodeficiency virus type 1. Tat is a protein secreted by hiv 1-infected cells and may have an additional effect on the pathogenesis of aids.

And (3) quercetin: is flos Sophorae Immaturus extract. Belongs to flavonoid compounds, can induce apoptosis, has strong antioxidant and strong anti-inflammatory effects, stabilizes basophilic cells and mast cells, reduces cholesterol and LDL, and inhibits 6 of 7 causes which promote canceration of cells. Has good effects of eliminating phlegm, relieving cough and relieving asthma. In addition, it also has effects of lowering blood pressure, enhancing capillary resistance, reducing capillary fragility, reducing blood lipid, dilating coronary artery, and increasing coronary blood flow. Can be used for treating chronic bronchitis. It also has adjuvant therapeutic effect on coronary heart disease and hypertension. Quercetin can remarkably inhibit the action of a cancer promoter, inhibit the growth of in vitro malignant cells, and inhibit the synthesis of DNA, RNA and protein of ehrlich ascites carcinoma cells. Quercetin has effects of inhibiting platelet aggregation and 5-hydroxytryptamine (5-HT) release. Quercetin has obvious inhibition effect on platelet aggregation induced by ADP, thrombin and Platelet Activating Factor (PAF), wherein the inhibition effect on PAF is strongest, and quercetin can also obviously inhibit rabbit platelet 3H-5-HT release induced by thrombin.

Tea polyphenol: is green tea extract. The tea polyphenol comprises the following main components: flavanones, anthocyanidins, flavonols, anthocyanins, phenolic acids and depside 6 compounds. The flavanones (mainly catechin compounds) are the most important and account for 60-80% of the total amount of tea polyphenol, and the flavanones are flavonoids, have low content of other phenolic substances, are main anticancer drugs and are used as antioxidants, so that the flavanones have anticancer activity in vivo and in vitro and inhibit 6 of 7 causes contributing to cell canceration. Inhibiting the activity of HIV-1 transcripts. The tea polyphenol has obvious prevention and treatment effects on the following diseases: lowering blood pressure, resisting blood coagulation, reducing blood lipid, preventing and treating cardiovascular diseases such as arteriosclerosis and thrombosis, lowering blood sugar, preventing and treating diabetes, and killing bacteria and viruses; preventing and treating diseases of gastrointestinal tract, respiratory tract, influenza, etc.; preventing and treating hepatitis, resisting aging, resisting cancer and enhancing immunity; has effects in strengthening teeth, preventing and treating periodontitis, preventing dental caries, and removing odor and toxic materials.

L-selenomethionine: is cardamine hirsute extract. In vitro and in vivo studies show anticancer effects, enhancing sperm motility, increasing organism oxidation resistance, enhancing immunity, and removing vivotoxin (such as heavy metal). A strong immunostimulator helps to restore low plasma selenium levels in cancer and AIDS patients. Inhibit 6 of 7 causes that contribute to cellular carcinogenesis.

Phosphatidylcholine: is soybean extract. Phosphatidylcholine is a commonly used additive in various nutritional foods. Phosphatidylcholine is a glycerophosphate formed by the esterification of a phosphatidyl group with the hydroxyl group of choline. Is an essential component of animal and plant cells, is rich in nerve tissues, particularly myelin sheaths and egg yolks, and is the most abundant phospholipid in animal cell membranes. Phosphatidylcholine rapidly transfers brain commands, and the faster the information transfer speed, the stronger the memory. The brain-strengthening food can enhance the intelligence of the infant and improve the learning efficiency. Especially for the fetus, the demand for phosphatidylcholine is extremely large in growth and development. In addition, phosphatidylcholine can also protect against fatty liver, such as alcoholic liver. Effectively prevent and protect the liver. The excess fat can be converted into smaller emulsion droplets to be discharged out of the body, so that the puerpera or the obese person can recover the body shape as soon as possible; can convert cholesterol and fatty acid in blood into ultrafine particles which are discharged from blood vessels, and has high sound and high density lipoprotein, so that the blood vessels recover elasticity, and blood flow is smooth, thus being known as 'blood vessel cleaner'. Can inhibit 4 of 7 causes that promote cell canceration.

Phosphatidylserine: is soybean meal extract. Phosphatidylserine is extracted from natural soybean oil residue (soybean meal), is an active substance of a cell membrane, is particularly present in brain cells, has the functions of mainly improving the function of nerve cells, regulating the conduction of nerve pulses and enhancing the memory function of the brain, can quickly enter the brain through a blood brain barrier after being absorbed due to strong lipophilicity, and plays the roles of relieving vascular smooth muscle cells and increasing blood supply to the brain. Phosphatidylserine is honored by the world nutrition community as an emerging "intelligent nutrient" following choline and "brain gold" DHA. Phosphatidylserine is the only phospholipid capable of regulating the functional state of key proteins in cell membranes, and is an indispensable substance for human bodies. Therefore, the dietary agent of phosphatidylserine does not bring extra burden to the body as long as the dietary agent is normally taken, and 4 of 7 causes which promote the canceration of cells can be inhibited through the certification of the drug administration in many countries.

Methionine: is fresh milk extract. Methionine is one of essential amino acids constituting the human body, is involved in protein synthesis, and is not produced in vivo by itself, so it must be obtained from the outside. If methionine is deficient, protein synthesis in vivo is hindered, causing body damage. Excessive oxidation of membrane lipids by oxygen radicals in the body is responsible for various damages to the body. Lipid peroxides damage primary and secondary lysosomal membranes, releasing acid phosphatase as a hydrolysis enzyme contained in lysosomes, causing damage to vital organelles such as cells and mitochondrial membranes, and methionine counteracts these damages through a variety of pathways. Has effects of protecting liver and myocardium, resisting depression, lowering blood pressure, and preventing and removing toxic substances. Methionine plays an important role in vivo biosynthesis and metabolism. Methionine is the most important methyl group donor in vivo, and is also extremely important in the modification and processing of proteins and nucleic acids. Methionine enkephalin can enhance TNFa production and NK cell activity, enhance the expression of interleukins IL-1, IL-2 and IL-6, relieve the enhancement inhibition of lymphocyte by hepatocyte injury, participate in regulating menstrual cycle, simultaneously exert central analgesic effect by the serial connection of methionine enkephalin and 5-hydroxytryptamine, and inhibit 7 inducers which promote cell canceration.

Liposome matrix: the liposome used in the invention is a spherical vesicle formed by bimolecular layers taking natural lipid molecule lecithin as a main component, the particle size is between 100nm and 200nm, the liposome has good biocompatibility and nontoxicity, the drug loading is high, the encapsulation efficiency is high, the stability is good, the safety is high, the liposome matrix can ensure that the active compound has sufficient utilization degree at the action part, the number of unit doses which are required to be taken by a patient every day is obviously reduced, the overall acceptability of the specified drug can be increased, and the drug effect is further improved. The lecithin is closely related to the proliferation, differentiation and canceration of cells, and the degradation product of the lecithin also participates in the signal transduction and metabolic regulation of the cells, and has various physiological effects of preventing aging, reducing blood fat, resisting tumors, strengthening brain, protecting liver and the like, so the liposome used by the invention not only serves as a drug carrier, but also can inhibit 7 inducers which promote the canceration of the cells.

Compared with the prior art, the human body immunity enhancer for preventing and treating the cancer has the following beneficial effects:

1. on the basis of the combination of the monarch, minister, assistant and guide theory and the modern medicine theory of the traditional Chinese medicine, the human body immunity enhancer for preventing and treating the cancer combines the natural traditional Chinese medicine extracted compound and a plurality of active compounds according to the proportion, can play the synergistic effect among the natural traditional Chinese medicine components, can enable the interaction among the plurality of active compounds, and improves the drug effect, thereby reducing the dosage of the traditional Chinese medicine extracted compound or the active compound, promoting the synergistic effect of the traditional Chinese medicine extracted compound and the active compound, and effectively resisting the cancer, the AIDS, the virus and other immunodeficiency diseases;

2 the human body immunity intensifier for preventing and treating cancer provided by the invention adopts the liposome matrix which is convenient to absorb, solves the difficult problem of absorbing a plurality of components with poor water solubility and low oil solubility, and on the premise of not increasing the drug loading capacity, when the liposome matrix composition is released into the cavity of the digestive tract, the liposome matrix composition is dispersed to form fine emulsion, so that the drug is kept in solution in the digestive tract, thereby avoiding the dissolution step which often limits the absorption of crystalline hydrophobic drugs;

3. the human immunity enhancer for preventing and treating the cancer can improve the autoimmunity of a human body, inhibits and removes cancer cells with pathological changes of the human body by relying on an autoimmunity system, can also increase the oxidation resistance of the organism and promote the discharge of vivotoxin, and is clinically proved to be capable of effectively reversing the destructive power of cancer, AIDS virus and other immunodeficiency diseases by combining a liposome delivery system, the total effective rate of years of clinical case statistics is more than 90 percent, and the curative effect is exact.

Detailed Description

To further illustrate the technical means adopted by the present invention and the effects thereof, the following detailed description is given with reference to the preferred embodiments of the present invention.

Example 1

A human immunity enhancer for preventing and treating cancer comprises the following components in parts by weight: 111 parts of echinacol, 144g parts of astragaloside IV, 111 parts of chrysin, 333 parts of coriolus versicolor polysaccharide, 22 parts of diindolylmethane, 60 parts of resveratrol, 80 parts of curcumin, 111 parts of dihydroquercetin, 111 parts of tea polyphenol, 2.22 parts of L-selenomethionine, 80 parts of phosphatidylcholine, 90 parts of phosphatidylserine, 444 parts of methionine and 3000 parts of liposome matrix emulsion.

heating 3000 parts of the prepared liposome matrix emulsion to 70-80 ℃, sequentially adding 80 parts of weighed phosphatidylcholine, 90 parts of phosphatidylserine and 444 parts of methionine, stirring until the phosphatidylcholine, the phosphatidylserine and the methionine are completely dissolved, and cooling to 50-60 ℃ for later use;

dissolving a corresponding amount of xanthan gum into 3000 parts of pure water according to the mass fraction of 0.3%, adding a specified proportion of natural perfume, stevia, sodium benzoate and potassium sorbate, and heating to 50-60 ℃ for later use after complete dissolution;

heating 3000 parts of pure water to 70-80 ℃, sequentially adding 111 parts of echinacol, 144 parts of astragaloside IV, 111 parts of chrysin, 333 parts of coriolus versicolor polysaccharide, 22 parts of diindolylmethane, 60 parts of resveratrol, 80 parts of curcumin, 111 parts of dihydroquercetin, 111 parts of tea polyphenol and 2.22 parts of L-selenomethionine, uniformly stirring, and cooling to 50-60 ℃ for later use;

Example 2

A human immunity enhancer for preventing and treating cancer comprises the following components in parts by weight: 160 parts of echinacol, 180 parts of astragaloside IV, 130 parts of chrysin, 450 parts of coriolus versicolor polysaccharide, 27 parts of diindolylmethane, 90 parts of resveratrol, 95 parts of curcumin, 160 parts of dihydroquercetin, 160 parts of tea polyphenol, 6.5 parts of L-selenomethionine, 100 parts of phosphatidylcholine, 120 parts of phosphatidylserine, 600 parts of methionine and 3500 parts of liposome matrix emulsion.

heating 3500 parts of the prepared liposome matrix emulsion to 70-80 ℃, sequentially adding 100 parts of weighed phosphatidylcholine, 120 parts of phosphatidylserine and 600 parts of methionine, stirring until the phosphatidylcholine, the phosphatidylserine and the methionine are completely dissolved, and cooling to 50-60 ℃ for later use;

dissolving a corresponding amount of xanthan gum into 3200 parts of pure water according to the mass fraction of 0.3%, adding a specified proportion of natural perfume, stevia, sodium benzoate and potassium sorbate, and heating to 50-60 ℃ for later use after complete dissolution;

heating 3200 parts of pure water to 70-80 ℃, sequentially adding 160 parts of echinacol, 180 parts of astragaloside IV, 130 parts of chrysin, 450 parts of coriolus versicolor polysaccharide, 27 parts of diindolylmethane, 90 parts of resveratrol, 95 parts of curcumin, 160 parts of dihydroquercetin, 160 parts of tea polyphenol and 6.5 parts of L-selenomethionine, uniformly stirring, and cooling to 50-60 ℃ for later use;

Example 3

A human immunity enhancer for preventing and treating cancer comprises the following components in parts by weight: 222 parts of echinacol, 288 parts of astragaloside, 177 parts of chrysin, 666 parts of coriolus versicolor polysaccharide, 33 parts of diindolylmethane, 111 parts of resveratrol, 111 parts of curcumin, 222 parts of dihydroquercetin, 222 parts of tea polyphenol, 11.1 parts of L-selenomethionine, 130 parts of phosphatidylcholine, 140 parts of phosphatidylserine, 888 parts of methionine and 4000 parts of liposome matrix emulsion.

heating 4000 parts of the prepared liposome matrix emulsion to 70-80 ℃, sequentially adding 130 parts of weighed phosphatidylcholine, 140 parts of phosphatidylserine and 888 parts of methionine, stirring until the phosphatidylcholine, the phosphatidylserine and the 888 are completely dissolved, and cooling to 50-60 ℃ for later use;

dissolving a corresponding amount of xanthan gum into 3500 parts of pure water according to the mass fraction of 0.3%, adding a specified proportion of natural perfume, stevia, sodium benzoate and potassium sorbate, and heating to 50-60 ℃ for later use after complete dissolution;

heating 3500 parts of pure water to 70-80 ℃, sequentially adding 222 parts of echinacol, 288 parts of astragaloside, 177 parts of chrysin, 666 parts of coriolus versicolor polysaccharide, 33 parts of diindolylmethane, 111 parts of resveratrol, 111 parts of curcumin, 222 parts of dihydroquercetin, 222 parts of tea polyphenol and 11.1 parts of L-selenomethionine, uniformly stirring, and cooling to 50-60 ℃ for later use;

Comparative example 1

Example 2 was followed except that no liposome base was used, i.e., water was used in place of the preformed liposome base emulsion in step two.

Comparative example 2

The procedure is as in example 2 except that phosphatidylcholine, phosphatidylserine, methionine are not added, i.e., no steps are included.

In vitro anticancer experiments

Study on inhibition of mouse liver cancer H22: the mouse liver cancer H22 tumor strain is taken out from liquid nitrogen, is inoculated in the abdominal cavity of an adult mouse after thawing and reviving, and the abdomen of the mouse is observed to be obviously enlarged after one week, so that the tumor loading is successful. Taking 70 tumor-bearing mice as the drugs to be detected, randomly dividing the tumor-bearing mice into 7 groups, and taking 10 mice in each group as a model group (equivalent distilled water), an experimental group 1-3 (drugs to be detected), a comparative group 1-2 (drugs to be detected) and a control group (cancer-eliminating oral liquid), wherein the daily average dose of the mice is calculated according to the daily average dose of clinical human bodies in each group, the mice are killed after 14 days, tumor tissues are completely stripped, the number of liver tumor metastases is observed and weighed, the average weight of solid tumors in each group is counted, P is less than 0.05 among the groups, and the difference has statistical significance. Tumor inhibition rates were calculated for each group.

The specific test results are shown in table 1.

TABLE 1 mouse liver cancer H22 weight inhibition

Group of	Inhibition ratio of liver metastasis (%)	Tumor inhibition Rate (%)
			Model set	--	--
Example 1	94.6	91.3
			Example 2	95.8	93.2
Example 3	92.5	90.6
			Comparative example 1	69.7	56.4
Comparative example 2	52.6	47.5
			Control group	74.2	55.8

The test results in table 1 show that the human immunity enhancer for cancer prevention and treatment provided in embodiments 1-3 of the present invention has an obvious inhibitory effect on mouse H22 liver cancer, the tumor inhibition rate is greater than 90.6%, and is much higher than 55.8% of the control group, the liposome substrate is not used in comparative example 1, and the tumor inhibition rate is only 56.4%, which indicates that the liposome substrate plays an important role in the absorption of phosphatidylcholine, phosphatidylserine, and methionine; the comparative example 2 does not contain the step two, and the prepared human immunity enhancer does not contain phosphatidylcholine, phosphatidylserine and methionine, and the tumor inhibition rate is only 47.5%, which shows that the phosphatidylcholine, the phosphatidylserine and the methionine play an important role in the anti-cancer effect of the invention, and also shows that the components of the human immunity enhancer of the invention have a synergistic effect. The test result shows that the human body immunity enhancer for preventing and treating the cancer can also obviously reduce the metastasis number of tumors in the liver.

Clinical typical cases

Case 1: liu, male, 24 years old, diagnosed with aids at 2006, 12 months, began receiving treatment with HIV antiretroviral drugs including ebivir, celecoxib, and ussti watts at 2007. His main manifestations are severe diarrhea and fatigue. The immunopotentiator provided by the invention is taken at 3/2 of 2007, 45mL is taken every day, and the oral administration is divided into 3 times. Diet limits sugar intake and physical exercise is performed daily. Day 18, 6.2007, physical examination b.p.110/70, Pulse 87, resp.24, Temp 36.5 ℃, with a significant increase in force. No HIV secondary manifestation or adverse reaction. Preliminary clinical studies have shown an improved relationship between CD4+ and viral load.

Case 2: he, male, 58 years old. Treatment with androgen suppression has previously been accepted. Axial scans showed that prostate cancer caused diffuse bone marrow replacement. Thrombolytic and fibroblast metastases to the right humeral head, left femur and right femur are seen in the neck, chest, lumbar spine, sacrospinous, right humerus, left and left sides. Metastases have spread to several ribs. The patient underwent bladder surgery to remove the tumor, but the bladder cancer was still active. The patient is very weak, the pelvic cavity is severely painful, the patient is difficult to fall asleep, walk and sit, and the patient is continuously sick and cannot eat. Difficult urination and long-term hematochezia. The hospital diagnoses advanced cancer. After taking the immunopotentiator of the invention for 5 days, patients feel stronger and more powerful, nausea is relieved, and bone pain is greatly relieved. Bladder bleeding remains a problem, but has been significantly reduced. The patient starts working again within 30 days and starts riding the motorcycle to work or leave work within 60 days.

Case 3: some in the plum, male, age 74. Patients presented with prostate cancer, elevated PSA, fatigue, severe carcinoma, to bleeding in urine, baseline lymphocyte subpopulation 3 and CBC showed very low immune system, long-term fatigue and lethargy. The ultrasound diagnosis is suspected to be aggressive prostate cancer. One week after the start of the use of the immunopotentiator of the present invention, the patient had a significant improvement in symptoms, his energy level increased, and the amount of blood in urination decreased to occasional drops. The bladder ultrasound examination at 2, 5 and follow-up ultrasound examination at 7, 23 days in 2018 showed: prostate cancer tumor shrinkage and bladder tumor itself disappearance.

Case 4: pi Chi, male. Age 70. Advanced metastatic prostate cancer, metastatic change of ribs, lumbar, sacral and thoracic vertebra diseases of patients, very weak bodies, frequent hemorrhage and nausea during urination. Prior to the start of the use of the immunopotentiator of the present invention, patients received 2 years of Lupron treatment. After the immunopotentiator is used, the disease condition of a patient starts to be stable and improved, the lumbar vertebra, sacral vertebra and thoracic vertebra lesions disappear, bleeding stops in the process of urination, and physical strength rises to be capable of self-driving travel, walking and hiking after one year, so that the patient can enjoy life beyond the expectation of the patient.

Case 5: one certain piece, woman, 65 years old. The breast cancer is diagnosed in 2016, chemotherapy is not needed after the operation, and the immunopotentiator is directly taken for 4 months, so that all indexes of the body are normal.

Case 6: liu Jie, male, 82 years old. Multiple diffuse infiltrative glioblastoma, the life cycle given by the oncologist is one or possibly two months. The patient received craniotomy and the tumor was excised. The pathology is manifested as diffuse infiltrative glioblastoma multiforme. By adopting the immunopotentiator of the invention for 15 days, patients can quickly get out of hospital and go home, and walk and speak normally. The patient survived 5 years and 7 months as a result of continued administration of the immunopotentiator of the present invention, which remained in remission for 11 months after the initial surgical resection and treatment.

Case 7: certain from the family of the mother, age 72. The serious diabetes is sent to the first aid room of the hospital and suffers aphasia and right side weakness. Initially, he was diagnosed with stroke and heparinization. However, further CT scans revealed a distending mass at the junction of the left parietal and frontal lobes. His initial AMAS test result is 105 (near critical). The immunopotentiator of the invention is adopted for three months and is reduced to 64 (normal).

Case 8: some ginger, female, 86 years old. Liver cancer was diagnosed in 2017 in 2 months, and the liver cancer was transferred to the head and suffered from headache swinging, and the immunopotentiator of the invention was orally administered in 45mL portions 3 times a day, the headache swinging was stopped after 10 days, the liver part B ultrasonic display was performed after 20 days, 1 tumor was less in 3 original tumors, and the remaining 2 tumors were reduced. After 6 months, the medicine is stopped, and no physical abnormality is found.

Case 9: lie, male, 60 years old. Polycythemia vera, mild myelofibrosis, is treated with hydroxyurea and ruckertinib phosphate. Extremely low immunity, manifested as: fatigue weakness, complications: skin diseases caused by addiction to the middle, and the sore can not be healed by long-term running water; foot ulceration with multiple sarcoma warts; chronic ulcer of oral cavity with tonsillitis. The immunopotentiator is taken by 45mL per day, and is orally taken for 3 times, and the symptoms of ulcer and sore surface stop after one week; after the medicine is taken for 20 days, the foot rot, the dental ulcer and the mesophilic dermatosis sores are all healed, the normal state is completely recovered, the individual is energetic, and the work starts again. After 2 months of administration, there was no wart in the foot. And checking that all indexes of the result are normal.

Case 10: zhangqi, male, age 78. In 2008, 3 months, the reason for the yellow urine examination is that the pancreatic tumor is pressed, and the biopsy conclusion is that: and (4) canceration. The patient refuses chemotherapy, the immunopotentiator is taken after the traditional Chinese medicine conservative treatment is adopted for one month, 45mL of the immunopotentiator is taken orally for 3 times every day, the taking time is 4 months, and the examination result is as follows: pancreatic tumors disappeared. After the body discomfort, the immunopotentiator is taken for one week, so far, the body is normal, and the double-knee synovitis is cured for many years.

The above description is only for the specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto, and other modifications or equivalent substitutions made by the technical solution of the present invention by the ordinary skilled in the art should be covered within the scope of the claims of the present invention without departing from the spirit and scope of the technical solution of the present invention.

Claims

1. A human immunity enhancer for preventing and treating cancers is characterized by comprising the following components in parts by weight: 222 parts of echinacol, 288 parts of astragaloside 144, 177 parts of chrysin 111, 666 parts of coriolus versicolor polysaccharide 333, 22-33 parts of diindolylmethane, 60-111 parts of resveratrol, 80-111 parts of curcumin, 222 parts of dihydroquercetin 111, 222 parts of tea polyphenol 111, 2.22-11.1 parts of L-selenomethionine, 80-130 parts of phosphatidylcholine, 90-140 parts of phosphatidylserine, 888 parts of methionine 444, and 4000 parts of liposome matrix emulsion 3000-.

2. The human immunity enhancer for cancer prevention and treatment according to claim 1, wherein the human immunity enhancer for cancer prevention and treatment comprises the following components in parts by weight: 200 parts of echinacol, 240 parts of astragaloside 160, 160 parts of chrysin 120, 500 parts of coriolus versicolor polysaccharide 400, 25-30 parts of diindolylmethane, 80-105 parts of resveratrol, 90-105 parts of curcumin, 200 parts of dihydroquercetin 130, 200 parts of tea polyphenol 130, 4.5-8.5 parts of L-selenomethionine, 90-120 parts of phosphatidylcholine, 130 parts of phosphatidylserine 100, 700 parts of methionine 500 and 3600 parts of liposome matrix emulsion 3400.

3. The human immunity enhancer for cancer prevention and treatment according to claim 1, wherein the human immunity enhancer for cancer prevention and treatment comprises the following components in parts by weight: 160 parts of echinacol, 180 parts of astragaloside IV, 130 parts of chrysin, 450 parts of coriolus versicolor polysaccharide, 27 parts of diindolylmethane, 90 parts of resveratrol, 95 parts of curcumin, 160 parts of dihydroquercetin, 160 parts of tea polyphenol, 6.5 parts of L-selenomethionine, 100 parts of phosphatidylcholine, 120 parts of phosphatidylserine, 600 parts of methionine and 3500 parts of liposome matrix emulsion.

4. A method for preparing the human immunity-enhancing agent according to claim 1, comprising the steps of: