CN110772475A - 一种益生菌牙膏 - Google Patents
一种益生菌牙膏 Download PDFInfo
- Publication number
- CN110772475A CN110772475A CN201911264121.6A CN201911264121A CN110772475A CN 110772475 A CN110772475 A CN 110772475A CN 201911264121 A CN201911264121 A CN 201911264121A CN 110772475 A CN110772475 A CN 110772475A
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- Prior art keywords
- toothpaste
- probiotic
- lactobacillus
- oral
- bacteria
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- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- Cosmetics (AREA)
Abstract
本发明公开了一种益生菌牙膏，所述牙膏包含灭活乳酸杆菌。本发明所述牙膏中添加的为经过灭活的乳酸杆菌粉，能快速抑制各种牙周病害菌之滋生，使牙周病害菌快速减少50％以上，并且杀菌效果能持续长达12小时，乳酸杆菌粉能够常温保存，且不会产生代谢产物。添加了乳酸杆菌的牙膏能恢复口腔菌群微生态平衡，从根源上解决口腔问题。
Description
技术领域
本发明涉及一种口腔保健品，具体涉及一种益生菌牙膏。
背景技术
随着生活节奏的加快，熬夜、情绪波动、饮食不规律成为现代人生活常态，各种亚健康问题严重干扰我们的生活。其中，口腔疾病困扰着不同年龄段的人群，也是许多慢性疾病发病的前兆。我国第三次口腔健康流行病学调查显示：高达97％的成年人正在遭受不同程度的口腔问题困扰，同时口腔作为呼吸道及胃肠道的起点，是人体健康的第一道屏障，口腔有害菌能够引起鼻腔、咽喉的病变，严重会导致肾脏、心脏等器官的问题，正所谓“病从口入”的说法。近年来越来越多的临床统计数据表明：很多慢性疾病与口腔菌群失衡密切相关，口腔疾病预防刻不容缓。
大多数的口腔疾病源于口腔微生态的失衡，口腔中的细菌被简单的划分为有益菌和有害菌两大类，其微生态环境的打破，主要是由于大量有害菌的定殖与滋生，主要以具核梭杆菌、伴放线杆菌为代表，这些有害菌存在我们的口腔并将口腔中残留的食物残渣分解成有害化合物，腐蚀我们的牙齿和牙龈的同时还会释放硫化氢气体，从而带来口臭；有益菌则是对口腔有益处的一类细菌，俗称益生菌，它通过竞争性抑制，来阻碍有害菌的生长，达到平衡口腔菌群的目的。相对于常规的口气清新剂，漱口水等产品来实现临时性的杀菌清新口气，化学性的清新在杀死异味菌的同时也杀死了有益菌，影响口腔环境。且目前市场上的漱口水维护口气清新大多是依靠添加香料掩盖原有口腔气味为主。
但益生菌在牙膏中的应用受到一定的限制：1、益生菌通常需要在低温环境中保存才能保证其有效活性，而牙膏在生产、物流、销售、使用的过程中，几乎不可能做到低温保存。例如，中国专利公开号为CN1947698A的发明专利申请公开了一种以天然矿物盐为培养基的益生菌牙膏，利用合适浓度的氯化钠来使活性益生菌休眠，但是牙膏体系中的氯化钠浓度会随着时间的推移而发生变化，也就不能保证牙膏中的益生菌的数量稳定；2、益生菌添加到牙膏中，在三个月后，部分膏体会出现发黄现象且会有肉眼可见的直径约1-3mm的淡黄色团聚物出现，膏体的这些变化主要是由益生菌的代谢废物引起，严重影响到牙膏的美观与使用。
中国专利申请号CN201510966066.0，针对益生菌不能常温保存的缺陷，利用口腔益生菌的冻干粉来替代活菌，并在冻干过程中加入一定量的低聚果糖、微晶纤维素和维生素D，可以有效保护冻干过程对菌体的损害。针对益生菌添加到牙膏中部分膏体会出现发黄的现象，还通过添加一定量的谷氨酸钠和氯化钙，抑制菌体的代谢活动。
发明内容
本发明的目的在于克服现有技术存在的不足之处而提供一种益生菌牙膏。
为实现上述目的，本发明采取的技术方案为：一种益生菌牙膏，包含灭活乳酸杆菌。
益生菌含有小分子功能肽、游离氨基酸、维生素等生理活性物质，能够选择性抑制口腔致病菌的活性，甚至与致病菌结合，降低致病菌在口腔中的数量，从而减少致病菌对口腔组织的不良影响。同时还可能通过调节口腔组织免疫能力，提高口腔组织的抗病能力，从而对龋病、牙周病、口腔异味等的预防发挥积极的作用。益生菌在生长过程所产生的代谢产物，具有抗微生物活性的物质，例如，有机酸、过氧化氢、抑菌素、抗附着剂、凝集分子等。
本发明所述牙膏中添加的为经过灭活的乳酸杆菌粉，所述灭活的方式优选采用热杀灭活方式，外抗菌功效试验显示：热杀益生菌在一个小时内，即能快速抑制各种牙周病害菌之滋生，使牙周病害菌快速减少50％以上，并且杀菌效果能持续长达12小时，乳酸杆菌粉能够常温保存，且不会产生代谢产物。本发明所述牙膏中添加了乳酸杆菌，能恢复口腔菌群微生态平衡，从根源上解决口腔问题。能够减少口臭、减少牙龈出血、减少口腔龋齿菌数、减少口腔牙周囊袋深度、减少口腔牙周病菌数、减少口腔总菌数。
优选地，所述乳酸杆菌为副干酪乳杆菌。
优选地，所述牙膏包含重量百分含量为0.3～0.8％的灭活乳酸杆菌。添加0.3～0.8％即可使乳酸杆菌在牙膏中充分发挥其功效。
优选地，所述牙膏还包含以下重量百分含量的组分：丁香花蕾油0.1～0.5％、蜜柑皮提取物0.001～0.01％、冰片0.1～0.3％、蜂胶提取物0.001～0.003％和香橼果皮油0.03～0.06％。
丁香花蕾油具有抗菌和抗炎效果，蜜柑皮(CITRUS UNSHIU)提取物的主要活性成分为辛弗林、橙皮苷和柚皮苷，具有抗敏、消炎和抑菌的作用。蜂胶提取物从蜂胶中提取出来，具有有效抗菌效果。冰片优选为天然冰片，具有消炎、清热解痛的作用，且作为辅药促进其他成分发挥其消炎抗菌的功效；香橼(CITRUS MEDICA LIMONUM)果皮油具有抗菌、抗感染、抗炎和解痉作用，能帮助受感染的牙齿，保护牙齿和齿腔的生长和发育，它可以消除牙齿上的细菌，还可以保护牙齿免于蛀牙。
所述牙膏中还包含上述添加量的丁香花蕾油、蜜柑皮提取物、冰片、蜂胶提取物和香橼果皮油与灭活乳酸杆菌配合使用，可促进降低口腔致病菌在口腔中的数量，减少致病菌对口腔组织的不良影响，还可能通过调节口腔组织免疫能力，提高口腔组织的抗病能力，从而对龋病、牙周病、口腔异味等的预防和治疗发挥积极的作用。
优选地，所述牙膏还包含以下重量百分含量的组分：赤藓醇1～5％和甘油6～10％。
优选地，所述牙膏还包含以下重量百分含量的组分：山梨醇3～8％、纤维素胶0.3～0.8％、月桂基葡糖苷3～7％、乳酸薄荷酯0.05～0.2％、苯甲酸钠0.1～0.6％和留兰香精油0.05～0.2％。本发明所述牙膏添加了月桂基葡糖苷作为发泡剂，为一种温和无毒的发泡剂。
优选地，所述牙膏由以下重量百分含量的组分组成：灭活乳酸杆菌0.5％、丁香花蕾油0.3％、蜜柑皮提取物0.003～0.006％、冰片0.2％、蜂胶提取物0.002％、赤藓醇3％、甘油8％、纤维素胶0.5％、月桂基葡糖苷4％、乳酸薄荷酯0.1％、山梨醇5％、苯甲酸钠0.4％、留兰香精油0.1％和余量的水。所述牙膏成分简单，没有不良气味和口感，而且具有良好的稳定性，对龋病、牙周病、口腔异味等的预治效果最为明显。
本发明的有益效果在于：本发明提供了一种益生菌牙膏，本发明所述牙膏中添加的为经过灭活的乳酸杆菌粉，能快速抑制各种牙周病害菌之滋生，使牙周病害菌快速减少50％以上，并且杀菌效果能持续长达12小时，乳酸杆菌粉能够常温保存，且不会产生代谢产物。添加了乳酸杆菌的牙膏能恢复口腔菌群微生态平衡，从根源上解决口腔问题。
具体实施方式
为更好的说明本发明的目的、技术方案和优点，下面将结合具体实施例对本发明作进一步说明。
实施例和对比例中的各原料均购自市场，其中，灭活乳酸杆菌购自山东中益企业孵化器有限公司，商品型号为ADP-1；蜂胶提取物购自韩国BioSpectrum公司，商品型号为HerbEx Propolis，该产品中蜂胶提取物的重量百分含量为2％；蜜柑皮(CITRUS UNSHIU)提取物购自韩国BioSpectrum公司，商品型号为EosidinTM，蜜柑皮提取物在该产品中的重量百分含量为1～2％。月桂基葡糖苷购自巴斯夫股份有限公司，商品型号为APG1200。
实施例和对比例所述牙膏的制备方法相同，包括以下步骤：
1、A相加水相锅中，搅拌升温到80-85℃，搅拌均匀，依次加入B，保温10分钟；
2、水相锅搅拌降温至40℃左右，将预先分散好的C项原料加入水相锅，搅拌分散均匀；
3、降温至35℃检验各项理化指标合格后过滤出料，即得所述牙膏。
测试实施例和对比例所述牙膏的性状，测试参数如下，均符合指标：
1、外观：半透明粘稠膏状；
2、pH值：5.83(5.5-6.5)；
实施例1～6和对比例1所述牙膏的配方见表1。
表1
实施例7
本发明所述牙膏对于牙周病的疗效观察方法和结果如下：
1、实验材料
测试样品为实施例1～6和对比例1所述牙膏。
2、实验方法：
选年龄35～50岁的患有牙周病的患者140例，男女各半，3个月内未服用过抗生素、激素；无系统性疾病。随机分为7组，每组20人，男女各半，每组分别使用对应的测试样品刷牙3个月。各组每天早、晚使用测试样品牙膏进行刷牙。受试者要求使用统一的牙刷，每次使用牙膏的长度应覆盖牙刷刷头，每次2min，持续1个月时间。观察其对牙周病常见症状的影响。
3、效果评价：
治疗效果的评定分为显效、有效和无效3种。显效指患者经治疗后牙龈出血、红肿、疼痛等症状消失，且质地坚固；有效指患者经治疗后牙龈出血、红肿、疼痛等症状大有好转或有少量出血现象，且质地有些疏松；无效指患者经治疗后牙龈出血、红肿、疼痛及其质地等均无改善。
4、试验结果：见表2。
表2 各组牙膏对牙周炎的缓解效果
| 组别 | 显效(％) | 有效(％) | 无效(％) | 有效率(％) |
| 实施例1 | 80 | 10 | 10 | 90 |
| 实施例2 | 65 | 20 | 15 | 85 |
| 实施例3 | 35 | 25 | 45 | 60 |
| 实施例4 | 50 | 15 | 35 | 65 |
| 实施例5 | 50 | 25 | 25 | 75 |
| 实施例6 | 30 | 20 | 50 | 50 |
| 对比例1 | 10 | 25 | 65 | 35 |
由上表2结果可知：本发明所述牙膏对牙周炎有显著的缓解作用，有效率达50％以上，同时试用者均表示，使用该牙膏后，口腔清新，没有异味。各组受试者使用各牙膏后无不良反应，即本发明牙膏安全，可长期使用。与实施例1相比，实施例5、实施例6和对比例1缺少其中的丁香花蕾油、蜜柑皮提取物、冰片、蜂胶提取物和灭活乳酸杆菌中的一种或几种，其有效率低于实施例1，说明丁香花蕾油、蜜柑皮提取物、冰片、蜂胶提取物和灭活乳酸杆菌对于牙周病有一定协同增效的效果。
最后所应当说明的是，以上实施例仅用以说明本发明的技术方案而非对本发明保护范围的限制，尽管参照较佳实施例对本发明作了详细说明，本领域的普通技术人员应当理解，可以对本发明的技术方案进行修改或者等同替换，而不脱离本发明技术方案的实质和范围。
Claims (7)
1.一种益生菌牙膏，其特征在于，包含灭活乳酸杆菌。
2.如权利要求1所述益生菌牙膏，其特征在于，所述乳酸杆菌为副干酪乳杆菌。
3.如权利要求1所述益生菌牙膏，其特征在于，所述牙膏包含重量百分含量为0.3～0.8％的灭活乳酸杆菌。
4.如权利要求3所述益生菌牙膏，其特征在于，所述牙膏还包含以下重量百分含量的组分：丁香花蕾油0.1～0.5％、蜜柑皮提取物0.001～0.01％、冰片0.1～0.3％、蜂胶提取物0.001～0.003％和香橼果皮油0.03～0.06％。
5.如权利要求4所述益生菌牙膏，其特征在于，所述牙膏还包含以下重量百分含量的组分：赤藓醇1～5％和甘油6～10％。
6.如权利要求5所述益生菌牙膏，其特征在于，所述牙膏还包含以下重量百分含量的组分：山梨醇3～8％、纤维素胶0.3～0.8％、月桂基葡糖苷3～7％、乳酸薄荷酯0.05～0.2％、苯甲酸钠0.1～0.6％和留兰香精油0.05～0.2％。
7.如权利要求1所述益生菌牙膏，其特征在于，所述牙膏由以下重量百分含量的组分组成：灭活乳酸杆菌0.5％、丁香花蕾油0.3％、蜜柑皮提取物0.003～0.006％、冰片0.2％、蜂胶提取物0.002％、赤藓醇3％、甘油8％、纤维素胶0.5％、月桂基葡糖苷4％、乳酸薄荷酯0.1％、山梨醇5％、苯甲酸钠0.4％、留兰香精油0.1％和余量的水。
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| CN115300414A (zh) * | 2022-09-02 | 2022-11-08 | 广东博然堂生物科技有限公司 | 一种无表面活性剂的漱口水及其制备方法 |
| CN115737458A (zh) * | 2022-10-18 | 2023-03-07 | 北京化工大学 | 一种可与电动牙刷联用的口腔抗菌材料及其制备方法 |
| CN116898741A (zh) * | 2023-08-18 | 2023-10-20 | 广州品硬生物科技有限公司 | 一种含溶菌酶和益生菌的牙龈修复牙膏及其制备方法 |
| CN118490609A (zh) * | 2024-05-29 | 2024-08-16 | 广州市比柔生物科技有限公司 | 一种用于防蛀抑菌含有益生菌的牙膏及其制备方法 |
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