CN110638693A - Compound essential oil for removing striae gravidarum and preparation method and application thereof - Google Patents
Compound essential oil for removing striae gravidarum and preparation method and application thereof Download PDFInfo
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- CN110638693A CN110638693A CN201911112686.2A CN201911112686A CN110638693A CN 110638693 A CN110638693 A CN 110638693A CN 201911112686 A CN201911112686 A CN 201911112686A CN 110638693 A CN110638693 A CN 110638693A
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- oil
- parts
- striae gravidarum
- compound
- essential oil
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
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Abstract
The invention relates to a striae gravidarum removing compound essential oil, a preparation method and an application thereof, wherein the striae gravidarum removing compound essential oil comprises the following components: vegetable oil complex, phytosterols, tocopheryl acetate, and bisabolol. The invention creatively and reasonably combines the four components of the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol to be used as the compound essential oil for removing the striae gravidarum, can provide the skin in the pregnancy period, toughens the skin, enhances the elasticity, repairs the injury in time, and effectively prevents and improves the striae gravidarum. The compound essential oil is free of mineral oil, essence, pigment and animal oil, so that the mildness of the product is improved, and sensitive skin during pregnancy is cared.
Description
Technical Field
The invention belongs to the technical field of cosmetics, and particularly relates to compound essential oil for removing striae gravidarum, and a preparation method and application thereof.
Background
Stretch marks are one kind of stretch marks, and the stretch marks are skin fiber breakage phenomena generated in the processes of pregnancy, body building and sudden weight increase of a human body, and are usually red, white or purple stripes. Stretch marks including fat marks and sports cracks are likely to occur in body parts with large movement amplitude, and in addition to the abdomen, the stretch marks also occur in body parts such as the inner and outer sides of the thigh, the knees, the buttocks, the lumbosacral and the like.
The abdominal wall tissues of the human body are respectively skin, elastic fibers of the skin, a subcutaneous fat layer, rectus abdominis composed of muscle fiber groups and muscle tendons, a preperitoneal fat layer and peritoneum from outside to inside. Under normal conditions, the elastic fibers of the skin keep a certain elasticity with the rectus abdominis and can freely stretch and contract within a certain limit. However, when the female is pregnant for more than 3 months, the enlarged uterus protrudes from the pelvic cavity and develops to the abdominal cavity, the abdomen begins to swell, the skin elastic fibers and abdominal muscles begin to extend, the stretch is more obvious after 6 months of pregnancy, the skin elastic fibers are gradually broken, and the surface of the abdominal skin slowly appears pink or purplish red irregular longitudinal cracks. After production, the broken elastic fibers are gradually restored, but are difficult to restore to the former state. The original skin cracks gradually fade and finally become silvery-white striae gravidarum.
There are many reports on stretch mark repair products in the prior art. CN108434024A discloses a horse oil stretch mark resistant repair cream and a preparation method thereof. The repair cream comprises horse oil and sodium alginate oligosaccharide, wherein the horse oil and the sodium alginate oligosaccharide account for 2-18% of the total weight of the horse oil stretch mark-resistant repair cream. The horse oil and the sodium alginate oligosaccharide are combined for use, so that the skin care product can effectively nourish each cortex, accelerate skin metabolism and enhance cell activity, can effectively activate epidermal growth factors, can improve the growth of human keratinocytes without manually increasing the epidermal growth factors, is integrated with the human keratinocytes, and is matched with other raw materials to enhance cell activity, promote the repair and synthesis of collagen and elastin, and improve the elasticity of skin, thereby realizing the effect of lightening striae gravidarum.
CN106619478A discloses a stretch mark repair essence composition, which comprises the following components in parts by dose: emulsifier: 1-2, water: and the balance, glycerol: 5-6, humectant: 5-7, stretch mark repair compound: 5-7, β -glucan: 2-3, anti-irritant: 0.1, preservative: 0.1-0.2, essence: 0.01-0.02; the raw material components of the stretch mark repairing essence composition provided by the invention are mild in medicine property, obvious in effect, free of stimulation and free of side effect.
CN103316157A discloses a compound essential oil for treating striae gravidarum, which is composed of orange flower essential oil, frankincense essential oil, chamomile essential oil, rose essential oil and grape seed essential oil according to weight components; the essential oil can effectively fade striae gravidarum, and in addition, the compound essential oil has a light and clear herbal medicine costus smell, so that the striae gravidarum is faded, the skin state can be improved, the skin is moistened, scars are faded, the skin is firmed, the skin is shinier and more elastic, and the aromatic smell in the essential oil can make the mood of a patient comfortable and pleasant.
However, related products in the prior art are relatively single in formula, cannot meet the requirements of skin in the gestation period, and have little effect; and the mildness is relatively low, and the contained additives such as mineral oil, pigment and essence components are not friendly to sensitive skin during pregnancy. Therefore, it is very necessary to develop a product which has high safety and mildness, can strengthen the skin, enhance the elasticity and remarkably improve the striae gravidarum.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide the compound essential oil for removing striae gravidarum and the preparation method and application thereof. The compound essential oil for removing striae gravidarum has the effects of strengthening skin, enhancing elasticity, repairing injury and effectively preventing and improving striae gravidarum.
In order to achieve the purpose, the invention adopts the following technical scheme:
in one aspect, the invention provides a compound essential oil for removing striae gravidarum, which comprises the following components: vegetable oil complex, phytosterols, tocopheryl acetate, and bisabolol.
The invention creatively and reasonably combines the four components of the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol, can provide the skin required by pregnancy, toughens the skin, enhances the elasticity, repairs the injury in time and effectively prevents and improves the striae gravidarum.
The specially added phytosterol can adjust skin hormone, so that the skin can keep self-renewal capacity; the phytosterol can also promote wound healing, enable muscles to proliferate, enhance capillary circulation and further accelerate the repair of striae gravidarum; the phytosterol has high permeability to skin, can promote the penetration of other effective components in essential oil, can maintain skin surface moisture, promote skin metabolism, inhibit skin inflammation, and has good spreadability and low liability to deterioration.
Wherein, the tocopherol acetate is used as an in vivo antioxidant, which can prevent the oxidation of the easily oxidized substances such as cell membranes, unsaturated fatty acids in cells and the like in the metabolism process of the organism, thereby having the function of preventing aging; the tocopherol acetate added to the essential oil according to the invention also serves to prevent oxidation of the essential oil. The bisabolol has good stability and good compatibility with skin, so that the bisabolol can protect and care the allergic skin; meanwhile, the bisabolol also has anti-inflammatory performance and bacteriostatic activity; the bisabolol can also increase the penetrability of other effective components in the essential oil and promote the effective absorption of other effective components.
The vegetable oil compound is the main functional component of the essential oil, has mild performance, is natural, safe and non-irritant, has no toxic or side effect, has aromatic smell and strong permeability, has the function of promoting tissue regeneration, has obvious repair effect on over-atrophic and retracted scars, can avoid water loss, prevents the skin from being over-dried and is rich in elasticity, and improves the skin state, thereby lightening stretch marks.
Preferably, the stretch mark removing compound essential oil comprises the following components in parts by weight: 10-95 parts of vegetable oil compound, 1-10 parts of phytosterol, 0.1-5 parts of tocopherol acetate and 1-10 parts of bisabolol.
The four components of the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol can play a better synergistic effect under the condition of the specific weight ratio.
The vegetable oil compound may be present in an amount of 10 parts, 20 parts, 25 parts, 30 parts, 40 parts, 50 parts, 55 parts, 60 parts, 70 parts, 80 parts, 95 parts, or the like.
The weight portion of the phytosterol can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts and the like.
The tocopherol acetate may be present in an amount of 0.5, 1, 2, 3, 3.5, 4, 4.5 or 5 parts by weight.
The weight portion of the bisabolol may be 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 parts, etc.
Preferably, the stretch mark removing compound essential oil comprises the following components in parts by weight: 10-95 parts of vegetable oil compound, 1-5 parts of phytosterol, 0.5-2 parts of tocopherol acetate and 1-5 parts of bisabolol.
Preferably, the vegetable oil complex comprises any one of canola oil, jojoba oil, neroli oil, olive fruit oil, wheat germ oil, sea buckthorn seed oil, rose oil, rosa canina fruit oil or almond oil, or a combination of at least two such as combinations of canola oil and jojoba seed oil, jojoba seed oil and neroli oil and olive fruit oil, rosehip oil and rosa canina fruit oil, and the like. Any other combination is not described in detail herein.
The canola oil contains a variety of fat-soluble vitamins, such as vitamin a, vitamin D and vitamin E, and is stable after long-term storage and heating, and its incorporation into essential oils for use, particularly in stretch mark-removing essential oils, is rarely reported.
The chemical molecular arrangement of the jojoba seed oil is very similar to that of human sebum, so that the jojoba seed oil is easily classified and absorbed by skin, is suitable for all skin types, and has excellent permeability and high temperature resistance; the base oil contains abundant vitamin A, B, E and minerals such as calcium, magnesium and the like, has good permeability, can permeate as long as gaps exist, and is base oil with extremely high stability and excellent ductility; it also has effects in smoothing pores, regulating oil secretion, moistening and keeping moisture, increasing skin moisture, and preventing wrinkle aging.
The neroli oil has the effects of enhancing cell activity, regulating immunity and the like, is very good for skin, can stimulate the regeneration of healthy new cells, has a certain youthful restoring magic power, is suitable for various skins, and is most helpful for dry or sensitive skins.
The olive fruit oil has good moistening effect, contains 1% of minerals such as calcium, iron and phosphorus, and also contains various vitamins such as vitamin A, B, D, K, E, minerals and microelements beneficial to human body. The wheat germ oil has effects in regulating endocrine, and preventing mottle, black speck and pigmentation; resisting oxidation, reducing lipid peroxide generation, promoting skin moisturizing function, moistening skin, and delaying aging; promoting metabolism and skin regeneration, removing wrinkle, preventing skin aging, and eliminating scar.
The sea buckthorn seed oil is a complex of various vitamins and bioactive substances, can nourish the skin, promote metabolism, resist allergy, sterilize and diminish inflammation, promote epithelial cell regeneration, has a repairing effect on the skin, can keep the acidic environment of the skin, and has strong permeability. The rose oil is suitable for various skins, has the characteristics of compactness and relaxation, nourishes the skins, delays aging, has the effects of strengthening and contracting micro-vessels, and has excellent rejuvenation effect on the aged skins.
The Rosa canina fruit oil has effects of preventing horny layer hyperkeratosis, nourishing skin, improving skin dryness, preventing skin aging and softening skin. The almond oil is rich in mineral substances, protein and various vitamins, is vegetable oil with excellent skin caring and moistening effects, is suitable for various skin types, and can effectively relieve the skin pruritus phenomenon and eliminate red swelling, dryness and inflammation.
Preferably, the vegetable oil complex is a combination of canola oil, jojoba oil, neroli oil, olive oil, wheat germ oil, sea buckthorn seed oil, rose oil, rosa canina fruit oil and almond oil.
The nine natural plant essential oils are mutually matched, have a synergistic effect, can strengthen skin to the maximum extent, enhance elasticity, moisturize and nourish skin, promote skin tissue regeneration, and effectively prevent and improve striae gravidarum.
Preferably, the vegetable oil compound is a combination of 10-70 parts of canola oil, 1-10 parts of jojoba seed oil, 1-5 parts of bitter orange flower oil, 1-5 parts of olive fruit oil, 0.5-5 parts of wheat germ oil, 0.5-5 parts of sea buckthorn seed oil, 1-5 parts of rose flower oil, 1-5 parts of rosa canina fruit oil and 1-5 parts of almond oil in parts by weight.
The nine natural plant essential oils play a stronger synergistic effect under the coordination of the parts by weight.
The parts by weight of the canola oil can be 10 parts, 20 parts, 30 parts, 40 parts, 50 parts, 60 parts or 70 parts and the like.
The jojoba seed oil can be 1 part, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts or 10 parts by weight.
The bitter orange flower oil can be 1 part, 2 parts, 3 parts, 4 parts or 5 parts by weight.
The olive fruit oil can be 1 part, 2 parts, 3 parts, 4 parts or 5 parts by weight.
The wheat germ oil can be 0.5 part, 1 part, 2 parts, 3 parts, 4 parts or 5 parts by weight.
The weight portion of the seabuckthorn seed oil can be 0.5 portion, 1 portion, 2 portions, 3 portions, 4 portions or 5 portions.
The rose oil can be 1 part, 2 parts, 3 parts, 4 parts or 5 parts by weight.
The weight portion of the rosa canina fruit oil can be 1 portion, 2 portions, 3 portions, 4 portions or 5 portions.
The almond oil can be 1 part, 2 parts, 3 parts, 4 parts or 5 parts by weight.
Preferably, the phytosterols comprise any one or a combination of at least two of beta-sitosterol, stigmasterol, campesterol, brassicasterol, avenasterol or ergosterol, such as a combination of beta-sitosterol and stigmasterol, a combination of campesterol and brassicasterol, a combination of avenasterol and ergosterol, and the like. Any other combination is not described in detail herein.
In another aspect, the invention provides a preparation method of the compound essential oil for removing striae gravidarum, which comprises the following steps: mixing the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing, filtering and discharging to obtain the striae gravidarum removing compound essential oil.
Preferably, the temperature of the dispersion is 20-30 ℃, such as 20 ℃, 22 ℃, 23 ℃, 24 ℃, 25 ℃, 26 ℃, 27 ℃, 28 ℃ or 30 ℃ and the like.
Preferably, the dispersion time is 5-20min, such as 5min, 8min, 10min, 12min, 14min, 15min, 17min or 20min, etc.
Preferably, the filtration refers to filtration using 150-250 mesh (e.g., 150 mesh, 160 mesh, 170 mesh, 180 mesh, 200 mesh, 220 mesh, 240 mesh, 250 mesh, etc.) filter cloth.
As a preferred technical scheme of the present invention, the preparation method specifically comprises: mixing the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 5-20min at the temperature of 20-30 ℃, filtering by using 150-mesh filter cloth with 250 meshes, and discharging to obtain the striae gravidarum removing composite essential oil.
In a further aspect, the invention provides a cosmetic product, which is characterized by comprising the compound essential oil for removing striae gravidarum.
Preferably, the compound essential oil for removing striae gravidarum is added in the cosmetic product in an amount of 0.5-10%, such as 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 10%, etc.
Preferably, the cosmetic product comprises a lotion, cream or essence.
Compared with the prior art, the invention has the following beneficial effects:
the invention creatively and reasonably combines the four components of the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol to be used as the compound essential oil for removing the striae gravidarum, can provide the skin in the pregnancy period, toughens the skin, enhances the elasticity, repairs the injury in time, and effectively prevents and improves the striae gravidarum. The compound essential oil is free of mineral oil, essence, pigment and animal oil, so that the mildness of the product is improved, and sensitive skin during pregnancy is cared.
Detailed Description
To further illustrate the technical means and effects of the present invention, the following further describes the technical solution of the present invention with reference to the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.
Example 1
The embodiment provides a compound essential oil for removing striae gravidarum, which comprises 60 parts of canola oil, 10 parts of jojoba seed oil, 3 parts of bitter orange flower oil, 3 parts of olive fruit oil, 2 parts of wheat germ oil, 5 parts of sea buckthorn seed oil, 5 parts of rose oil, 3 parts of rosa canina fruit oil, 2 parts of almond oil, 3 parts of beta-sitosterol, 1 part of tocopherol acetate and 3 parts of bisabolol.
The preparation method comprises the following steps: mixing the vegetable oil, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 10min at 25 ℃, filtering by using 200-mesh filter cloth, and discharging to obtain the compound essential oil for removing the striae gravidarum.
Example 2
The embodiment provides a compound essential oil for removing striae gravidarum, which comprises 40 parts of canola oil, 5 parts of jojoba seed oil, 5 parts of bitter orange flower oil, 5 parts of olive fruit oil, 5 parts of wheat germ oil, 5 parts of sea buckthorn seed oil, 5 parts of rose oil, 3 parts of rosa canina fruit oil, 2 parts of almond oil, 10 parts of beta-sitosterol, 5 parts of tocopherol acetate and 10 parts of bisabolol.
The preparation method comprises the following steps: mixing the vegetable oil, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 20min at the temperature of 20 ℃, filtering by using 250-mesh filter cloth, and discharging to obtain the compound essential oil for removing the striae gravidarum.
Example 3
The embodiment provides a compound essential oil for removing striae gravidarum, which comprises 70 parts of canola oil, 2 parts of jojoba seed oil, 3 parts of bitter orange flower oil, 5 parts of olive fruit oil, 5 parts of wheat germ oil, 3 parts of sea buckthorn seed oil, 2 parts of rose oil, 4 parts of rosa canina fruit oil, 1 part of almond oil, 2 parts of beta-sitosterol, 1 part of tocopherol acetate and 2 parts of bisabolol.
The preparation method comprises the following steps: mixing the vegetable oil, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 10min at 30 ℃, filtering by using 200-mesh filter cloth, and discharging to obtain the compound essential oil for removing the striae gravidarum.
Example 4
The embodiment provides a compound essential oil for removing striae gravidarum, which comprises 65 parts of canola oil, 10 parts of jojoba seed oil, 3 parts of bitter orange flower oil, 3 parts of olive fruit oil, 2 parts of wheat germ oil, 5 parts of sea buckthorn seed oil, 5 parts of rose oil, 3 parts of beta-sitosterol, 1 part of tocopherol acetate and 3 parts of bisabolol.
The preparation method comprises the following steps: mixing the vegetable oil, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 10min at 25 ℃, filtering by using 200-mesh filter cloth, and discharging to obtain the compound essential oil for removing the striae gravidarum.
Example 5
The embodiment provides a compound essential oil for removing striae gravidarum, which comprises 65 parts of canola oil, 10 parts of jojoba seed oil, 3 parts of olive oil, 5 parts of sea buckthorn seed oil, 5 parts of rose oil, 3 parts of rosa canina fruit oil, 2 parts of almond oil, 3 parts of beta-sitosterol, 1 part of tocopherol acetate and 3 parts of bisabolol.
The preparation method comprises the following steps: mixing the vegetable oil, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 10min at 25 ℃, filtering by using 200-mesh filter cloth, and discharging to obtain the compound essential oil for removing the striae gravidarum.
Example 6
The embodiment provides a compound essential oil for removing striae gravidarum, which comprises 65 parts of canola oil, 3 parts of neroli oil, 3 parts of olive oil, 2 parts of wheat germ oil, 10 parts of sea buckthorn seed oil, 5 parts of rosa canina fruit oil, 5 parts of almond oil, 3 parts of beta-sitosterol, 1 part of tocopheryl acetate and 3 parts of bisabolol.
The preparation method comprises the following steps: mixing the vegetable oil, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 10min at 25 ℃, filtering by using 200-mesh filter cloth, and discharging to obtain the compound essential oil for removing the striae gravidarum.
Example 7
The embodiment provides stretch mark removing compound essential oil which comprises 73 parts of canola oil, 3 parts of olive oil, 2 parts of wheat germ oil, 5 parts of sea buckthorn seed oil, 5 parts of rose oil, 3 parts of rosa canina fruit oil, 2 parts of almond oil, 3 parts of beta-sitosterol, 1 part of tocopherol acetate and 3 parts of bisabolol.
The preparation method comprises the following steps: mixing the vegetable oil, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 10min at 25 ℃, filtering by using 200-mesh filter cloth, and discharging to obtain the compound essential oil for removing the striae gravidarum.
Example 8
The embodiment provides a compound essential oil for removing striae gravidarum, which comprises 20 parts of jojoba seed oil, 10 parts of bitter orange flower oil, 10 parts of olive fruit oil, 10 parts of wheat germ oil, 5 parts of sea buckthorn seed oil, 10 parts of rose oil, 5 parts of rosa canina fruit oil, 5 parts of almond oil, 10 parts of beta-sitosterol, 5 parts of tocopherol acetate and 10 parts of bisabolol.
The preparation method comprises the following steps: mixing the vegetable oil, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 10min at 25 ℃, filtering by using 200-mesh filter cloth, and discharging to obtain the compound essential oil for removing the striae gravidarum.
Comparative example 1
This comparative example provides a striae gravidarum-removing compound essential oil whose formulation differs from that of example 1 only in that it does not contain beta-sitosterol and 63 parts of canola oil, the rest remaining unchanged.
Comparative example 2
This comparative example provides a striae gravidarum removing compound essential oil whose formulation is different from that of example 1 only in that tocopherol acetate is not contained and canola oil is 61 parts, and the others are kept unchanged.
Comparative example 3
This comparative example provides a striae gravidarum-removing compound essential oil whose formulation is different from that of example 1 only in that it does not contain bisabolol, and 63 parts of canola oil, the rest remaining unchanged.
Test example 1
Safety evaluation test
(1) Erythrocyte hemolysis test.
The specific method comprises the following steps: selecting healthy rabbits, taking 9mL of blood from heart, adding 1mL of 2% potassium oxalate solution, centrifuging, discarding supernatant, diluting the precipitate to 20mL with 20mmol/L PBS solution, and storing at 4 ℃ for later use. The products prepared in examples 1-8 were diluted to different concentrations with PBS solution and 5 concentration gradients were set for each sample. Taking 10mL of a diluent of a sample to be tested, adding 200 μ L of the erythrocyte suspension (controlling the final concentration of the sample to be 5, 10, 50, 100 and 500mg/mL respectively), taking distilled water as a positive control, taking a PBS solution as a negative control, mixing the mixture gently, incubating the mixture for 30min at 37 ℃, centrifuging the mixture for 10min at the rotating speed of 2000r/min, taking the supernatant, testing the absorbance (A560) of the supernatant at 560nm by using a spectrophotometer, and calculating the hemolysis rate according to the following formula;
the results are shown in Table 1.
TABLE 1
As can be seen from the data in Table 1: the hemolysis rate of the compound essential oil is still nearly 0 when the concentration is 500mg/mL, which shows that the compound essential oil has no adverse reaction to human body and high safety.
(2) And (4) testing a human body.
The specific method comprises the following steps: 80 healthy female volunteers aged 18-35 years without allergic history were selected and tested with the products of examples 1-8, respectively (10 volunteers were randomly selected for each group of products). After cleaning the right abdomen of the volunteer, the spot tester with each group of samples is pasted on the selected position of the right abdomen by using a non-irritating adhesive tape, and the pasted spot tester is lightly pressed by fingers to be uniformly pasted on the skin for 48 hours. The volunteer is ordered to keep the spot patch part dry within 48h, and avoid violent exercise, scratching spot test part, long-time sunlight irradiation and the like. After 48h, the tester is removed and marked, and after 30min, judgment is carried out under sufficient light after the pressure marks disappear.
The skin adverse reaction grading criteria are shown in table 2:
TABLE 2
The test results are shown in table 3:
TABLE 3
As can be seen from the data in Table 3: the subjects basically have negative reactions, and the compound essential oil disclosed by the invention is judged to have no adverse reaction to human bodies and to have high safety.
Test example 2
Striae gravidarum removing effect evaluation test
The specific method comprises the following steps: 180 volunteers were selected to respectively try the products of examples 1-8 and comparative examples 1-3 for experiments (15 volunteers were randomly selected for each group of products) and 15 volunteers without any product were used as a control group, and all volunteers were patients with obvious striae of pregnancy 1-5 years after delivery. Respectively applying 11 groups of compound essential oil products to the affected part, 3-4 times per day, each time 100 μ L, regularly observing, determining as invalid if striae gravidarum phenomenon is unchanged after continuously using for 1 month, and stopping applying; the effective cases are continuously used for 2 months, and the experimental results are evaluated.
The efficacy evaluation criteria were as follows:
the effect is shown: the striae gravidarum becomes lighter and the range is reduced by more than 50 percent;
the method has the following advantages: the striae gravidarum becomes light and the range is reduced by more than 20% and is not more than 50%;
light effect: striae gravidarum becomes pale and the range is narrowed by no more than 20%;
and (4) invalidation: striae gravidarum is not lightened and the range is not narrowed.
Total effective rate% (number of effective cases + number of effective cases)/total cases × 100%.
The results are shown in Table 4.
TABLE 4
From the data in table 4, it can be seen that: the striae gravidarum removing compound essential oil has obvious positive effects on the lightening and narrowing of striae gravidarum; when the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol exist simultaneously, the effect of removing the striae gravidarum is better; when the vegetable oil compound is the combination of the low erucic acid rapeseed oil, the jojoba seed oil, the bitter orange flower oil, the olive fruit oil, the wheat germ oil, the sea buckthorn seed oil, the rose oil, the rosa canina fruit oil and the almond oil, the effect of removing the striae gravidarum is better.
Test example 3
Skin elasticity evaluation test
The specific method comprises the following steps: the skin elasticity test was carried out on 180 volunteers of test example 2 (0, 15, one, 45 and two months respectively from the product) using a skin elasticity tester comprising 10 parameters from R0 to R9, wherein R2 represents the total elasticity index. The closer the index is to 1, the better the skin elasticity is reflected. The results are shown in Table 5.
TABLE 5
From the data in table 5, it can be seen that: the stretch mark removing compound essential oil has remarkable elasticity recovery capability on the skin part of the stretch mark, and particularly has stronger skin elasticity recovery capability when the vegetable oil compound is selected from the combination of canola oil, jojoba oil, neroli oil, olive oil, wheat germ oil, sea buckthorn seed oil, rose oil, rosa canina fruit oil and almond oil, and when the vegetable oil compound, phytosterol, tocopherol acetate and bisabolol exist simultaneously.
Test example 4
Striae gravidarum color evaluation test
The specific method comprises the following steps: the affected parts of 180 volunteers in test example 2 were subjected to striae gravidarum color measurement using a colorimeter (monitoring the applied products for 0 day, 15 days, one month, 45 days and two months), and the lower the color, the stronger the striae gravidarum removal ability is reflected. The results are shown in Table 6.
TABLE 6
From the data in table 6, it can be seen that: the striae gravidarum removing compound essential oil has a positive effect on fading the color of the striae gravidarum, and particularly has stronger fading capability on the color of the striae gravidarum when the vegetable oil compound is selected from the combination of canola oil, jojoba oil, bitter orange flower oil, olive oil, wheat germ oil, sea buckthorn seed oil, rose oil, rosa canina fruit oil and almond oil, and when the vegetable oil compound, phytosterol, tocopherol acetate and bisabolol exist simultaneously.
The applicant states that the invention is illustrated by the above examples to a compound essential oil for removing stretch marks, a preparation method and an application thereof, but the invention is not limited by the above examples, that is, the invention is not necessarily dependent on the above examples to be implemented. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.
Claims (10)
1. The striae gravidarum removing compound essential oil is characterized by comprising the following components: vegetable oil complex, phytosterols, tocopheryl acetate, and bisabolol.
2. The striae gravidarum removing compound essential oil according to claim 1, which comprises the following components in parts by weight: 10-95 parts of vegetable oil compound, 1-10 parts of phytosterol, 0.1-5 parts of tocopherol acetate and 1-10 parts of bisabolol;
preferably, the stretch mark removing compound essential oil comprises the following components in parts by weight: 10-95 parts of vegetable oil compound, 1-5 parts of phytosterol, 0.5-2 parts of tocopherol acetate and 1-5 parts of bisabolol.
3. The compound essential oil for removing striae gravidarum of claim 1 or 2, wherein the vegetable oil compound comprises any one of canola oil, jojoba oil, neroli oil, olive oil, wheat germ oil, sea buckthorn seed oil, rose oil, rosa canina oil or almond oil or a combination of at least two of the foregoing.
4. The striae gravidarum-removing complex essential oil according to any one of claims 1 to 3, wherein the vegetable oil complex is a combination of canola oil, jojoba oil, neroli oil, olive oil, wheat germ oil, sea buckthorn seed oil, rose oil, rosa canina fruit oil, and almond oil.
5. The striae gravidarum-removing compound essential oil according to any one of claims 1 to 4, wherein the vegetable oil compound comprises, by weight, a combination of 10 to 70 parts of canola oil, 1 to 10 parts of jojoba oil, 1 to 5 parts of bitter orange flower oil, 1 to 5 parts of olive oil, 0.5 to 5 parts of wheat germ oil, 0.5 to 5 parts of sea buckthorn seed oil, 1 to 5 parts of rose flower oil, 1 to 5 parts of rosa canina fruit oil and 1 to 5 parts of almond oil.
6. The striae gravidarum-removing complex essential oil according to any one of claims 1 to 5, wherein the phytosterol comprises any one or a combination of at least two of beta-sitosterol, stigmasterol, campesterol, brassicasterol, avenasterol or ergosterol.
7. The method for preparing the compound essential oil for removing striae gravidarum according to any one of claims 1 to 6, wherein the preparation method comprises the following steps: mixing the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing, filtering and discharging to obtain the striae gravidarum removing compound essential oil.
8. The method for preparing the compound essential oil for removing striae gravidarum according to claim 7, wherein the dispersion temperature is 20-30 ℃;
preferably, the dispersing time is 5-20 min;
preferably, the filtration refers to filtration using 150-.
9. The preparation method of the compound essential oil for removing striae gravidarum according to claim 7 or 8, which specifically comprises the following steps: mixing the vegetable oil compound, the phytosterol, the tocopherol acetate and the bisabolol according to the formula amount, dispersing for 5-20min at the temperature of 20-30 ℃, filtering by using 150-mesh filter cloth with 250 meshes, and discharging to obtain the striae gravidarum removing composite essential oil.
10. A cosmetic product characterized in that it comprises the striae gravidarum-removing complex essential oil according to any one of claims 1 to 6;
preferably, the addition amount of the compound essential oil for removing striae gravidarum in the cosmetic product is 0.5-10%;
preferably, the cosmetic product comprises a lotion, cream or essence.
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| CN111603412A (en) * | 2020-06-15 | 2020-09-01 | 广州花言草语生物科技有限公司 | Essential oil for removing striae gravidarum and preparation method thereof |
| CN113101245A (en) * | 2021-04-02 | 2021-07-13 | 广东袋鼠妈妈生物科技有限公司 | Composition and care product with effect of repairing stretch marks |
| CN115887299A (en) * | 2022-04-25 | 2023-04-04 | 上海元维科技有限公司 | Elastic composition, body care essential oil thereof and preparation method |
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| CN113101245A (en) * | 2021-04-02 | 2021-07-13 | 广东袋鼠妈妈生物科技有限公司 | Composition and care product with effect of repairing stretch marks |
| CN115887299A (en) * | 2022-04-25 | 2023-04-04 | 上海元维科技有限公司 | Elastic composition, body care essential oil thereof and preparation method |
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Address after: No.5, area 1, community 8, Xinke village, JUNHE street, Baiyun District, Guangzhou City, Guangdong Province 510000 Applicant after: Guangzhou Biotechnology Co.,Ltd. Address before: 510000 No.7, East Street, xinkeshang village, JUNHE street, Baiyun District, Guangzhou City, Guangdong Province Applicant before: Guangzhou Biotechnology Co.,Ltd. |
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Application publication date: 20200103 |