CN110559207B - Skin care compositions - Google Patents
Skin care compositions Download PDFInfo
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- CN110559207B CN110559207B CN201910935359.0A CN201910935359A CN110559207B CN 110559207 B CN110559207 B CN 110559207B CN 201910935359 A CN201910935359 A CN 201910935359A CN 110559207 B CN110559207 B CN 110559207B
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- skin care
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- 239000000203 mixture Substances 0.000 title claims abstract description 61
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims abstract description 76
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims abstract description 50
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 46
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229960004889 salicylic acid Drugs 0.000 claims abstract description 38
- QBYIENPQHBMVBV-HFEGYEGKSA-N (2R)-2-hydroxy-2-phenylacetic acid Chemical compound O[C@@H](C(O)=O)c1ccccc1.O[C@@H](C(O)=O)c1ccccc1 QBYIENPQHBMVBV-HFEGYEGKSA-N 0.000 claims abstract description 23
- ZGSCRDSBTNQPMS-UJURSFKZSA-N 3-O-Ethylascorbic acid Chemical compound CCOC1=C(O)C(=O)O[C@@H]1[C@@H](O)CO ZGSCRDSBTNQPMS-UJURSFKZSA-N 0.000 claims abstract description 23
- 229940120145 3-o-ethylascorbic acid Drugs 0.000 claims abstract description 23
- IWYDHOAUDWTVEP-UHFFFAOYSA-N R-2-phenyl-2-hydroxyacetic acid Natural products OC(=O)C(O)C1=CC=CC=C1 IWYDHOAUDWTVEP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 229960002510 mandelic acid Drugs 0.000 claims abstract description 23
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 23
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 23
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 23
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 23
- KIUVQMGRTDPAFR-UHFFFAOYSA-N benzoic acid 2-hydroxy-2-phenylpropanamide Chemical compound C(C1=CC=CC=C1)(=O)O.OC(C(=O)N)(C)C1=CC=CC=C1 KIUVQMGRTDPAFR-UHFFFAOYSA-N 0.000 claims abstract description 16
- 240000003421 Dianthus chinensis Species 0.000 claims abstract description 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 105
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 78
- 238000003756 stirring Methods 0.000 claims description 50
- 238000005303 weighing Methods 0.000 claims description 40
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 24
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 24
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 24
- XXJWXESWEXIICW-UHFFFAOYSA-N diethylene glycol monoethyl ether Chemical compound CCOCCOCCO XXJWXESWEXIICW-UHFFFAOYSA-N 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 19
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 claims description 16
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 claims description 16
- 239000011259 mixed solution Substances 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 14
- 239000000463 material Substances 0.000 claims description 14
- 238000001816 cooling Methods 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- VKIJBOMCWLTQBD-UHFFFAOYSA-N benzoic acid N-(2-hydroxyphenyl)propanamide Chemical compound C(C1=CC=CC=C1)(=O)O.C(CC)(=O)NC1=C(C=CC=C1)O VKIJBOMCWLTQBD-UHFFFAOYSA-N 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 229940071826 hydroxyethyl cellulose Drugs 0.000 claims 1
- 229960004063 propylene glycol Drugs 0.000 claims 1
- 235000013772 propylene glycol Nutrition 0.000 claims 1
- 229940083608 sodium hydroxide Drugs 0.000 claims 1
- 235000011121 sodium hydroxide Nutrition 0.000 claims 1
- 229920000832 Cutin Polymers 0.000 abstract description 9
- 230000007815 allergy Effects 0.000 abstract description 7
- 206010020751 Hypersensitivity Diseases 0.000 abstract description 5
- 208000026935 allergic disease Diseases 0.000 abstract description 5
- 230000000052 comparative effect Effects 0.000 description 85
- 210000003491 skin Anatomy 0.000 description 74
- 238000012360 testing method Methods 0.000 description 23
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 21
- 230000000694 effects Effects 0.000 description 19
- 238000002474 experimental method Methods 0.000 description 13
- 230000009286 beneficial effect Effects 0.000 description 10
- 230000003266 anti-allergic effect Effects 0.000 description 9
- 230000008901 benefit Effects 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 239000007933 dermal patch Substances 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- 239000000230 xanthan gum Substances 0.000 description 5
- 229920001285 xanthan gum Polymers 0.000 description 5
- 235000010493 xanthan gum Nutrition 0.000 description 5
- 229940082509 xanthan gum Drugs 0.000 description 5
- 206010013786 Dry skin Diseases 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical group CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000037336 dry skin Effects 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 230000001815 facial effect Effects 0.000 description 4
- 230000007794 irritation Effects 0.000 description 4
- 238000012795 verification Methods 0.000 description 4
- 201000004624 Dermatitis Diseases 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- 206010040880 Skin irritation Diseases 0.000 description 3
- 230000000172 allergic effect Effects 0.000 description 3
- 208000010668 atopic eczema Diseases 0.000 description 3
- 230000035515 penetration Effects 0.000 description 3
- 230000036556 skin irritation Effects 0.000 description 3
- 231100000475 skin irritation Toxicity 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical group OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000011782 Keratins Human genes 0.000 description 2
- 108010076876 Keratins Proteins 0.000 description 2
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 2
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 2
- 206010040844 Skin exfoliation Diseases 0.000 description 2
- 206010040914 Skin reaction Diseases 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000035622 drinking Effects 0.000 description 2
- 238000004299 exfoliation Methods 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000037307 sensitive skin Effects 0.000 description 2
- 230000037380 skin damage Effects 0.000 description 2
- 230000035483 skin reaction Effects 0.000 description 2
- 231100000430 skin reaction Toxicity 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- HDXIQHTUNGFJIC-UHFFFAOYSA-N (25R)-spirost-5-en-3beta-ol 3-O-<O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside> Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC1OC(CO)C(O)C(O)C1OC1OC(C)C(O)C(O)C1O HDXIQHTUNGFJIC-UHFFFAOYSA-N 0.000 description 1
- QGMGHALXLXKCBD-UHFFFAOYSA-N 4-amino-n-(2-aminophenyl)benzamide Chemical compound C1=CC(N)=CC=C1C(=O)NC1=CC=CC=C1N QGMGHALXLXKCBD-UHFFFAOYSA-N 0.000 description 1
- 208000021959 Abnormal metabolism Diseases 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
- VNONINPVFQTJOC-RXEYMUOJSA-N Collettiside III Natural products O([C@@H]1[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)[C@H](CO)O[C@@H]1O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]5[C@H](C)[C@@]6(O[C@H]5C4)OC[C@H](C)CC6)CC3)CC=2)CC1)[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1 VNONINPVFQTJOC-RXEYMUOJSA-N 0.000 description 1
- 241000219322 Dianthus Species 0.000 description 1
- 240000006497 Dianthus caryophyllus Species 0.000 description 1
- 235000009355 Dianthus caryophyllus Nutrition 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010040830 Skin discomfort Diseases 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 230000032798 delamination Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- -1 dianilin Chemical compound 0.000 description 1
- VNONINPVFQTJOC-ZGXDEBHDSA-N dioscin Chemical compound O([C@@H]1[C@@H](CO)O[C@H]([C@@H]([C@H]1O)O[C@H]1[C@@H]([C@H](O)[C@@H](O)[C@H](C)O1)O)O[C@@H]1CC2=CC[C@H]3[C@@H]4C[C@H]5[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@@H]([C@]1(OC[C@H](C)CC1)O5)C)[C@@H]1O[C@@H](C)[C@H](O)[C@@H](O)[C@H]1O VNONINPVFQTJOC-ZGXDEBHDSA-N 0.000 description 1
- CJNUQCDDINHHHD-APRUHSSNSA-N dioscin Natural products C[C@@H]1CC[C@@]2(OC1)O[C@H]3C[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@H]6[C@H]5CC[C@]4(C)[C@H]3[C@@H]2C)O[C@@H]7O[C@H](CO)[C@@H](O[C@@H]8O[C@@H](C)[C@H](O)[C@@H](O)[C@H]8O)[C@H](O)[C@H]7O[C@@H]9O[C@@H](C)[C@H](O)[C@@H](O)[C@H]9O CJNUQCDDINHHHD-APRUHSSNSA-N 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- 229940089161 ginsenoside Drugs 0.000 description 1
- 229930182494 ginsenoside Natural products 0.000 description 1
- 239000008169 grapeseed oil Substances 0.000 description 1
- 230000036074 healthy skin Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 230000000774 hypoallergenic effect Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000006371 metabolic abnormality Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- VNONINPVFQTJOC-UHFFFAOYSA-N polyphyllin III Natural products O1C2(OCC(C)CC2)C(C)C(C2(CCC3C4(C)CC5)C)C1CC2C3CC=C4CC5OC(C(C1O)OC2C(C(O)C(O)C(C)O2)O)OC(CO)C1OC1OC(C)C(O)C(O)C1O VNONINPVFQTJOC-UHFFFAOYSA-N 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000008591 skin barrier function Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000005808 skin problem Effects 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a skin care composition comprising glycolic acid, mandelic acid, macromolecular salicylic acid, hydroxyphenylpropionamide benzoic acid, dianthus, vitamin B6 and 3-O-ethyl ascorbic acid. The skin care composition has good stability, and can better remove cutin and resist allergy.
Description
Technical Field
The invention relates to the field of skin care products, and particularly relates to a skin care composition and a preparation method thereof.
Background
Modern people often slow down metabolism speed due to the influence of factors such as contact with external environmental conditions, unbalanced drinking, abnormal work and rest, staying up all night, smoking, drinking, emotion and the like, horny cells cannot naturally fall off due to abnormal metabolism, the skin becomes thick, rough and dark as old horny substances of the skin accumulate more, and the applied care products are often blocked by the excessively thick barrier.
There are the product of many exfoliations on the market at present for peel off coarse stratum corneum, thereby reach the effect that the skin is tender smooth or brighten the complexion, but most effect exfoliate the product and all have obvious amazing experience sense, the skin is dry and dehydrated seriously after using, the inflammation appears even, and can lead to the phenomenon that the cutin is too thin moreover, arouse other skin problems, let the customer catch a vogue to this kind of product, perhaps use after purchasing and just bundle a loft several times, no longer buy again.
Patent CN104398435A discloses a mild exfoliating mask, which comprises the following components in percentage by weight: 0.5-1.0% of fruit acid, 0.03-3% of grape seed oil, 0.02-2% of ginsenoside, 0.01-1% of dioscin, 4-10% of volcanic mud, 5-10% of glycerol, 2-4% of propylene glycol, 0.05-2% of salicylic acid, 20-40% of kaolin and the balance of deionized water. In patent CN104398435A, fruit acid and salicylic acid are used, and we know that two factors determining the effect of fruit acid and salicylic acid are concentration and pH, respectively, and the effect of fruit acid and salicylic acid is weakened by too low concentration or too high pH. However, the salicylic acid used in patent CN104398435A has very low solubility in water, which results in the reduction of the exfoliating effect of the exfoliating mask, and the insoluble salicylic acid brings certain irritation to the skin with skin damage and sensitive skin, and also affects the stability of the formula system.
Accordingly, in the field of skin care products, there is a need for the development of a skin care composition having good stability, effective in removing keratin, and resistant to allergy.
Disclosure of Invention
In view of the above, an object of the present invention is to provide a skin care composition having good stability and capable of effectively removing keratin and resisting allergy.
Therefore, the invention provides the following technical scheme.
In a first aspect, the present invention provides a skin care composition comprising glycolic acid, mandelic acid, macromolecular salicylic acid, hydroxyphenylpropionamide benzoic acid, dianiline, vitamin B6 and 3-O-ethyl ascorbic acid.
In a preferred embodiment, the parts by weight of the glycolic acid are 3 to 5; for example, the parts by weight of glycolic acid may be 3, 3.2, 3.5, 3.7, 4, 4.3, 4.7, 4.9 or 5.
In a preferred embodiment, the weight part of the mandelic acid is 1 to 3; for example, the weight parts of mandelic acid may be 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2, 2.1, 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.8, 2.9 or 3.
In a preferred embodiment, the weight part of the macromolecular salicylic acid is 1-3; for example, the parts by weight of the macromolecular salicylic acid may be 1, 1.2, 1.3, 1.5, 1.7, 2, 2.2, 2.5, 2.7 or 3.
In a preferred embodiment, the hydroxyphenyl propionamide benzoic acid is present in an amount of from 0.005 to 0.1 parts by weight; for example, the hydroxyphenyl propionamide benzoic acid may be present in a weight fraction of 0.005, 0.010, 0.015, 0.020, 0.025, 0.030, 0.035, 0.04, 0.045, 0.05, 0.055, 0.06, 0.065, 0.07, 0.075, 0.08, 0.085, 0.09, 0.095, or 0.1.
In a preferred embodiment, the weight portion of the caryophyllin is 0.005-0.01; for example, the weight fraction of the caryophyllin may be 0.005, 0.006, 0.007, 0.008, 0.009, or 0.01.
In a preferred embodiment, the vitamin B6 is present in an amount of 0.1 to 1 parts by weight; for example, the vitamin B6 may be present in an amount of 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 or 1 parts by weight.
In a preferred embodiment, the 3-O-ethyl ascorbic acid is present in a weight fraction of 1.5 to 3; for example, the 3-O-ethyl ascorbic acid can be present in 1.5, 1.7, 1.9, 2, 2.2, 2.5, 2.7, or 3 parts by weight.
In a preferred embodiment, the composition further comprises propylene glycol and/or ethoxydiglycol.
In a more preferred embodiment, the propylene glycol is present in an amount of from 10 to 15 parts by weight; for example, the propylene glycol may be present in 10, 10.5, 11, 11.5, 12, 12.5, 13, 13.5, 14, 14.5, or 15 parts by weight.
In a more preferred embodiment, the ethoxydiglycol is in a weight fraction of 1-2; for example, the weight fraction of ethoxydiglycol may be 1, 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9 or 2.
In a preferred embodiment, the composition further comprises hydroxyethyl cellulose and/or xanthan gum.
In a more preferred embodiment, the hydroxyethyl cellulose is present in an amount of 0.2 to 0.5 parts by weight; for example, the hydroxyethyl cellulose may be present in a weight fraction of 0.2, 0.25, 0.3, 0.35, 0.4, 0.45 or 0.5.
In a preferred embodiment, the xanthan gum is present in an amount of 0.2 to 0.5 parts by weight; for example, the xanthan gum may be present in a weight fraction of 0.2, 0.25, 0.3, 0.35, 0.4, 0.45 or 0.5.
In a preferred embodiment, the composition further comprises sodium hydroxide and/or potassium hydroxide.
In a more preferred embodiment, the sodium hydroxide is present in an amount of 1.2 to 1.3 parts by weight; for example, the sodium hydroxide is 1.2, 1.21, 1.22, 1.23, 1.24, 1.25, 1.26, 1.27, 1.28, 1.29 or 1.3 by weight.
In a more preferred embodiment, the weight fraction of potassium hydroxide is 1.2 to 1.3; for example, the potassium hydroxide is 1.2, 1.21, 1.22, 1.23, 1.24, 1.25, 1.26, 1.27, 1.28, 1.29, or 1.3 parts by weight.
In a second aspect, the present invention provides a method of preparing a skin care composition, the method comprising the steps of:
s1, weighing propylene glycol, hydroxyethyl cellulose and water, adding the propylene glycol, the hydroxyethyl cellulose and the water into a container, uniformly stirring, heating to 75-80 ℃, uniformly stirring, and cooling to below 45 ℃;
s2, weighing glycolic acid, mandelic acid and sodium hydroxide, adding into the mixed solution obtained in S1, and uniformly stirring;
s3, weighing caryophyllin, ethoxy diglycol and propylene glycol, adding into the mixed solution obtained in the step S2, and uniformly stirring;
s4, weighing vitamin B6, 3-O-ethyl ascorbic acid, hydroxyphenyl propionamide benzoic acid and macromolecular salicylic acid, sequentially adding the weighed materials into the mixed liquid obtained in the step S3, and uniformly stirring.
In a third aspect, a skin care product is provided, said product comprising a composition according to the present invention.
In a fourth aspect, a pharmaceutical composition is provided comprising a safe and effective amount of a skin care composition according to the present invention.
In a fifth aspect, there is provided the use of a composition according to the invention in the preparation of a skin care product or a pharmaceutical composition.
In the invention, the pharmaceutical composition comprises the skin care composition and pharmaceutically acceptable auxiliary materials.
In the present invention, a safe and effective amount refers to an amount of a compound or composition sufficient to significantly induce a positive benefit, preferably a positive skin tissue appearance or feel benefit, including the benefits disclosed herein, either individually or in combination, but low enough to avoid serious side effects, i.e., to provide a reasonable benefit to risk ratio, within the scope of sound judgment of the skilled artisan.
Common salicylic acid has fat solubility, is limited by the characteristics of low solubility in water due to the fact that the salicylic acid is dissolved in an organic solvent, low molecular weight, strong permeability and unstable property, is easy to form crystals to reduce curative effect, can enter into an epidermal layer, and can cause additional stimulation to skin with skin damage and sensitive skin. In the invention, the macromolecular salicylic acid is formed by grafting xanthan gum on the hydroxyl part of the salicylic acid, the xanthan gum is a hydrophilic group, and the hydrophilic group is grafted, so that the molecular weight of the salicylic acid is increased, the solubility of the salicylic acid in water is also increased, the seepage force is weakened, and the irritation is reduced.
Compared with the prior art, the invention has the beneficial effects that:
the invention uses the glycolic acid, the mandelic acid and the macromolecular salicylic acid as acids with the exfoliating effect, can soften and exfoliate skin cutin, promote the skin cuticle metabolism and ensure that the skin is smoother and white. The weight portion of the glycolic acid is controlled within the range of 3-5, the weight portion of the mandelic acid is controlled within the range of 1-3, the weight portion of the macromolecular salicylic acid is controlled within the range of 1-3, and the exfoliating effect is better. In addition, the macromolecular salicylic acid is used, so that the dissolubility is higher, and the irritation is lower.
The invention uses hydroxyphenylpropionamide benzoic acid, dianilin, vitamin B6 and 3-O-ethyl ascorbic acid as skin relieving components, and can calm and relieve skin discomfort, resist inflammation and relieve itching. The anti-allergic effect is better by controlling the weight part of the hydroxyphenyl propionamide benzoic acid within the range of 0.005-0.1, the effect is not good when the weight part of the hydroxyphenyl propionamide benzoic acid is too low, and the skin irritation or allergy is caused when the weight part of the hydroxyphenyl propionamide benzoic acid is too high. The weight parts of the caryophyllin are controlled within the range of 0.005-0.1, the weight parts of the vitamin B6 are controlled within the range of 0.1-1, the weight parts of the 3-O-ethyl ascorbic acid are controlled within the range of 1.5-3, the calming and relieving effect is better, the effect is not obvious when the weight parts of the caryophyllin, the vitamin B6 and the 3-O-ethyl ascorbic acid are too low, and the skin irritation and allergy can be caused when the weight parts of the caryophyllin, the vitamin B6 and the 3-O-ethyl ascorbic acid are too high.
The invention uses sodium hydroxide or potassium hydroxide as a neutralizer, and can well neutralize acidic substances. The weight portion of the sodium hydroxide is controlled within the range of 1.2-1.3, the weight portion of the potassium hydroxide is controlled within the range of 1.2-1.3, the neutralization effect is better, too low weight portion of the sodium hydroxide or the potassium hydroxide causes too large acidity of the skin care composition, the skin irritation is too strong, and too high weight portion of the sodium hydroxide or the potassium hydroxide causes the cutin removing effect to be weakened.
The invention uses propylene glycol and ethoxy diglycol as penetration enhancer, which can improve the permeability of skin barrier and promote the penetration of effective substances into skin. The penetration promoting effect is better when the weight portion of the propylene glycol is controlled within the range of 10-15 and the weight portion of the ethoxy diglycol is controlled within the range of 1-2, the penetration promoting effect is not obvious when the weight portion of the propylene glycol and the ethoxy diglycol is too low, and the skin is irritated, reddened and heated when the weight portion of the propylene glycol and the ethoxy diglycol is too high.
In addition, the skin care composition can keep excellent stability at low temperature (about minus 18 ℃) to high temperature (45 ℃), has no delamination or precipitation and has good stability.
Moreover, the skin care composition is safe and nontoxic through human safety verification.
Detailed Description
The present invention will be described in detail below with reference to specific embodiments and examples, and the advantages and various effects of the present invention will be more clearly apparent therefrom. It will be understood by those skilled in the art that these specific embodiments and examples are for the purpose of illustrating the invention and are not to be construed as limiting the invention.
The present invention will be described in more detail below with reference to examples, but the present invention is not limited to these examples.
Example 1
This example provides a skin care composition, comprising, in parts by weight:
3 parts of glycolic acid, 1 part of mandelic acid, 1 part of macromolecular salicylic acid, 0.005 part of hydroxyphenylpropionamide benzoic acid, 10 parts of propylene glycol, 1 part of ethoxydiglycol, 0.2 part of hydroxyethyl cellulose, 1.2 parts of sodium hydroxide, 0.005 part of dianthus, 0.1 part of vitamin B6, 1.5 parts of 3-O-ethyl ascorbic acid and a proper amount of water.
The skin care composition of this example was prepared as follows:
s1, weighing 5 parts of propylene glycol, 0.2 part of hydroxyethyl cellulose and a proper amount of water, adding the materials into a container, uniformly stirring, heating to 75 ℃, uniformly stirring, and cooling to 40 ℃;
s2, weighing 3 parts of glycolic acid, 1 part of mandelic acid and 1.2 parts of sodium hydroxide, adding into the mixed solution obtained in the S1, and uniformly stirring;
s3, weighing 0.005 part of caryophyllin, 1 part of ethoxy diglycol and 5 parts of propylene glycol, adding into the mixed liquid obtained in the step S2, and uniformly stirring;
s4, weighing 0.1 part of vitamin B6, 1.5 parts of 3-O-ethyl ascorbic acid, 0.005 part of hydroxyphenylpropionamide benzoic acid and 1 part of macromolecular salicylic acid, sequentially adding the weighed materials into the mixed liquid obtained in the step S3, and uniformly stirring.
Example 2
This example provides a skin care composition comprising, in parts by weight:
5 parts of glycolic acid, 3 parts of mandelic acid, 3 parts of macromolecular salicylic acid, 0.1 part of hydroxyphenylpropionamide benzoic acid, 15 parts of propylene glycol, 2 parts of ethoxydiglycol, 0.5 part of hydroxyethyl cellulose, 1.3 parts of sodium hydroxide, 0.01 part of dianthus chinensis, 1 part of vitamin B6, 3 parts of 3-O-ethyl ascorbic acid and a proper amount of water.
The skin care composition of this example was prepared as follows:
s1, weighing 7.5 parts of propylene glycol, 0.5 part of hydroxyethyl cellulose and a proper amount of water, adding the materials into a container, uniformly stirring, heating to 80 ℃, uniformly stirring, and cooling to 40 ℃;
s2, weighing 5 parts of glycolic acid, 3 parts of mandelic acid and 1.3 parts of sodium hydroxide, adding into the mixed solution obtained in the S1, and uniformly stirring;
s3, weighing 0.01 part of caryophyllin, 2 parts of ethoxy diglycol and 7.5 parts of propylene glycol, adding into the mixed liquid obtained in the step S2, and uniformly stirring;
s4, weighing 1 part of vitamin B6, 3 parts of 3-O-ethyl ascorbic acid, 0.1 part of hydroxyphenylpropionamide benzoic acid and 3 parts of macromolecular salicylic acid, sequentially adding the weighed materials into the mixed liquid obtained in the step S3, and uniformly stirring.
Example 3
This example provides a skin care composition, comprising, in parts by weight:
4 parts of glycolic acid, 2 parts of mandelic acid, 2 parts of macromolecular salicylic acid, 0.01 part of hydroxyphenylpropionamide benzoic acid, 14 parts of propylene glycol, 1.5 parts of ethoxydiglycol, 0.3 part of hydroxyethyl cellulose, 1.25 parts of sodium hydroxide, 0.008 part of dianilin, 0.5 part of vitamin B6, 2 parts of 3-O-ethyl ascorbic acid and a proper amount of water.
The skin care composition of this example was prepared as follows:
s1, weighing 7 parts of propylene glycol, 0.3 part of hydroxyethyl cellulose and a proper amount of water, adding into a container, uniformly stirring, heating to 80 ℃, uniformly stirring, and cooling to 40 ℃;
s2, weighing 4 parts of glycolic acid, 2 parts of mandelic acid and 1.25 parts of sodium hydroxide, adding into the mixed solution obtained in the S1, and uniformly stirring;
s3, weighing 0.008 part of caryophyllin, 1.5 parts of ethoxy diglycol and 7 parts of propylene glycol, adding into the mixed liquid obtained in the step S2, and uniformly stirring;
s4, weighing 0.5 part of vitamin B6, 2 parts of 3-O-ethyl ascorbic acid, 0.01 part of hydroxyphenylpropionamide benzoic acid and 2 parts of macromolecular salicylic acid, sequentially adding the weighed materials into the mixed solution obtained in the step S3, and uniformly stirring.
Comparative example 1
To further illustrate the beneficial effects of the present invention, comparative example 1 is provided, which comparative example 1 differs from example 3 in that: the glycolic acid of the present invention was replaced with malic acid.
The comparative skin care composition was prepared as follows:
s1, weighing 7 parts of propylene glycol, 0.3 part of hydroxyethyl cellulose and a proper amount of water, adding into a container, uniformly stirring, heating to 80 ℃, uniformly stirring, and cooling to 40 ℃;
s2, weighing 4 parts of malic acid, 2 parts of mandelic acid and 1.25 parts of sodium hydroxide, adding into the mixed solution obtained in the S1, and uniformly stirring;
s3, weighing 0.008 part of caryophyllin, 1.5 parts of ethoxy diglycol and 7 parts of propylene glycol, adding into the mixed liquid obtained in the step S2, and uniformly stirring;
s4, weighing 0.5 part of vitamin B6, 2 parts of 3-O-ethyl ascorbic acid, 0.01 part of hydroxyphenylpropionamide benzoic acid and 2 parts of macromolecular salicylic acid, sequentially adding the weighed materials into the mixed liquid obtained in the step S3, and uniformly stirring.
Comparative example 2
To further illustrate the beneficial effects of the present invention, comparative example 2 is provided, which comparative example 2 differs from example 3 in that: the hydroxyphenylpropionamide benzoic acid of the invention is replaced by ascorbyl palmitate.
The comparative skin care composition was prepared as follows:
s1, weighing 7 parts of propylene glycol, 0.3 part of hydroxyethyl cellulose and a proper amount of water, adding into a container, uniformly stirring, heating to 80 ℃, uniformly stirring, and cooling to 40 ℃;
s2, weighing 4 parts of glycolic acid, 2 parts of mandelic acid and 1.25 parts of sodium hydroxide, adding into the mixed solution obtained in the S1, and uniformly stirring;
s3, weighing 0.008 part of caryophyllin, 1.5 parts of ethoxy diglycol and 7 parts of propylene glycol, adding into the mixed liquid obtained in the step S2, and uniformly stirring;
s4, weighing 0.5 part of vitamin B6, 2 parts of 3-O-ethyl ascorbic acid, 0.01 part of ascorbyl palmitate and 2 parts of macromolecular salicylic acid, sequentially adding the components into the mixed solution obtained in the step S3, and uniformly stirring.
Comparative example 3
To further illustrate the beneficial effects of the present invention, comparative example 3 is provided, which comparative example 3 differs from example 3 in that: the ethoxydiglycol of the present invention is replaced with ethanol.
The comparative skin care composition was prepared as follows:
s1, weighing 7 parts of propylene glycol, 0.3 part of hydroxyethyl cellulose and a proper amount of water, adding into a container, uniformly stirring, heating to 80 ℃, uniformly stirring, and cooling to 40 ℃;
s2, weighing 4 parts of glycolic acid, 2 parts of mandelic acid and 1.25 parts of sodium hydroxide, adding into the mixed solution obtained in the S1, and uniformly stirring;
s3, weighing 0.008 part of caryophyllin, 1.5 parts of ethanol and 7 parts of propylene glycol, adding into the mixed solution obtained in the step S2, and uniformly stirring; s4, weighing 0.5 part of vitamin B6, 2 parts of 3-O-ethyl ascorbic acid, 0.01 part of hydroxyphenylpropionamide benzoic acid and 2 parts of macromolecular salicylic acid, sequentially adding the weighed materials into the mixed liquid obtained in the step S3, and uniformly stirring.
Comparative example 4
To further illustrate the beneficial effects of the present invention, comparative example 4 is provided, which comparative example 4 differs from example 3 in that: the weight portion of the mandelic acid is adjusted to 0.5.
The comparative skin care composition was prepared as follows:
s1, weighing 7 parts of propylene glycol, 0.3 part of hydroxyethyl cellulose and a proper amount of water, adding the materials into a container, uniformly stirring, heating to 80 ℃, uniformly stirring, and cooling to 40 ℃;
s2, weighing 4 parts of glycolic acid, 0.5 part of mandelic acid and 1.25 parts of sodium hydroxide, adding into the mixed solution obtained in the S1, and uniformly stirring;
s3, weighing 0.008 part of caryophyllin, 1.5 parts of ethoxy diglycol and 7 parts of propylene glycol, adding into the mixed liquid obtained in the step S2, and uniformly stirring;
s4, weighing 0.5 part of vitamin B6, 2 parts of 3-O-ethyl ascorbic acid, 0.01 part of hydroxyphenylpropionamide benzoic acid and 2 parts of macromolecular salicylic acid, sequentially adding the weighed materials into the mixed liquid obtained in the step S3, and uniformly stirring.
Comparative example 5
To further illustrate the beneficial effects of the present invention, comparative example 5 is provided, which comparative example 5 differs from example 3 in that: the weight portion of the mandelic acid is adjusted to 3.5.
The comparative skin care composition was prepared as follows:
s1, weighing 7 parts of propylene glycol, 0.3 part of hydroxyethyl cellulose and a proper amount of water, adding into a container, uniformly stirring, heating to 80 ℃, uniformly stirring, and cooling to 40 ℃;
s2, weighing 4 parts of glycolic acid, 3.5 parts of mandelic acid and 1.25 parts of sodium hydroxide, adding into the mixed solution obtained in the S1, and uniformly stirring;
s3, weighing 0.008 part of caryophyllin, 1.5 parts of ethoxy diglycol and 7 parts of propylene glycol, adding into the mixed liquid obtained in the step S2, and uniformly stirring;
s4, weighing 0.5 part of vitamin B6, 2 parts of 3-O-ethyl ascorbic acid, 0.01 part of hydroxyphenylpropionamide benzoic acid and 2 parts of macromolecular salicylic acid, sequentially adding the weighed materials into the mixed solution obtained in the step S3, and uniformly stirring.
Comparative example 6
To further illustrate the benefits of the present invention, a mild exfoliating mask is provided, which is prepared using the method in CN 104398435A.
Experiment 1: security verification
And (3) testing a sample: the samples prepared in inventive examples 1-3 and comparative examples 1-6.
Subjects: selecting 90 volunteers, wherein the volunteers are 20-65 years old, have healthy skin and no allergic history of skin diseases, and accord with the volunteer selection standard of the test subject. Randomly grouped into 9 groups of 10 people each.
The experimental principle is as follows: the safety of the skin care composition on human skin is verified by referring to a human skin patch test method in a fifth part human safety and efficacy evaluation detection method in 'cosmetic hygiene Specification 2015', and a skin patch test is a diagnosis mode for determining delayed contact allergy of an organism and is set according to the IV-type skin allergy principle.
The experimental method comprises the following steps:
according to the human skin patch test described in the technical Specification for safety of cosmetics (2015 edition), a patch test device containing a test sample was applied to the back or forearm of a subject with a hypoallergenic tape, and the patch was applied to the skin uniformly by pressing the palm for 24 hours. The skin care compositions prepared in examples 1 to 3 of the present invention and comparative examples 1 to 6 were tested for potential adverse reactions to human skin.
The skin patch test reaction grading standards are shown in the following table 1.
TABLE 1 grading Standard of skin Patch test response
The experimental results are shown in table 2 below.
TABLE 2 results of Security verification
The security verification result shows that:
the skin reactions of the volunteers are observed 24h after the experiment, and the skin reactions of the volunteers are negative, which shows that the skin care composition has good safety and no irritation to human skin. After the formula system of the mild exfoliating facial mask is adjusted and the mild exfoliating facial mask prepared by the prior art is used, some volunteers have suspicious reactions and weak erythema.
Experiment 2: exfoliating test
And (3) testing a sample: the samples prepared in inventive examples 1-3 and comparative examples 1-6.
Subjects: 270 volunteers are selected, the age is 20-65 years old, the volunteers have dry skin, rough skin or thickened cutin, the volunteers are divided into 9 groups of 30 persons, and each group of the volunteers has 10 persons with dry skin, rough skin and thickened cutin.
The experimental method comprises the following steps: the samples prepared in examples 1 to 3 and comparative examples 1 to 6 were applied to volunteers 1 time per day for 30 consecutive days.
The results of the 270 volunteers testing the samples are shown in Table 3 below.
TABLE 3 results of exfoliating tests
Results of the exfoliation test showed:
the skin care composition has remarkable improvement on dry skin, rough skin and thickened cutin, and has remarkably higher improvement degree on the dry skin, the rough skin and the thickened cutin than skin care compositions prepared in a comparative ratio, and the skin care composition achieves more ideal cutin removal effect by further optimizing a formula system of the skin care composition, and the remarkable improvement result can reach more than 75 percent.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 4.1 is provided, which is different from example 3 in that: adjusting the weight part of the glycolic acid to 2.5 parts;
comparative example 4.2 is provided, which is distinguished from example 3 by the following: adjusting the weight part of macromolecular salicylic acid to 0.5 part;
comparative example 4.3 is provided, which comparative example 4.3 differs from example 3 in that: adjusting the weight portion of the dianthus chinensis to 0.003 portion;
comparative example 4.4 is provided, which is different from example 3 in that: adjusting the weight part of sodium hydroxide to 1 part;
comparative example 4.5 is provided, which is distinguished from example 3 by the following: adjusting the weight part of the hydroxyethyl cellulose to 0.1 part;
skin care compositions prepared in conjunction with the preparation method of the present invention were tested according to the test method of experiment 2. The skin care compositions prepared in comparative examples 4.1, 4.2, 4.3, 4.4, and 4.5 were evaluated for their exfoliating effect. The results were similar to those in comparative example 4 above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 5.1 is provided, which comparative example 5.1 differs from example 3 in that: adjusting the weight part of the glycolic acid to 6 parts;
comparative example 5.2 is provided, which comparative example 5.2 differs from example 3 in that: adjusting the weight part of the macromolecular salicylic acid to 4 parts;
comparative example 5.3 is provided, which comparative example 5.3 differs from example 3 in that: adjusting the weight part of the dianthus caryophyllus extract to 0.05 part;
comparative example 5.4 is provided, which comparative example 5.4 differs from example 3 in that: adjusting the weight part of sodium hydroxide to 1.5 parts;
comparative example 5.5 is provided, which comparative example 5.5 differs from example 3 in that: adjusting the weight part of the hydroxyethyl cellulose to 1 part;
skin care compositions prepared in conjunction with the preparation method of the present invention were tested according to the test method of experiment 2. The skin care compositions prepared in comparative example 5.1, comparative example 5.2, comparative example 5.3, comparative example 5.4, and comparative example 5.5 were evaluated for exfoliating effect. The results were similar to those in comparative example 5 described above.
Experiment 3: antiallergic test
And (3) testing a sample: the samples prepared in comparative examples 1 to 6 and examples 1 to 3 of the present invention are described.
Subjects: 180 volunteers aged 20-65 years and having allergy are selected, and divided into 9 groups of 20 persons.
The experimental method comprises the following steps:
washing after applying on face for 15 min, using 1 time per day, continuously trying for 2 weeks, taking pictures and archiving every week, comparing the pictures of day 0, week 1 and week 2, wherein,
the effect is obvious when all the allergic symptoms of the face skin disappear;
the improvement of the allergic symptoms of the facial skin is effective;
non-improvement of facial skin symptoms is ineffective;
the specific test results are shown in table 4 below.
TABLE 4 results of the antiallergic test
The result of the antiallergic test shows that:
the skin care composition has a remarkable anti-allergic effect. Example 3 in comparison with examples 1-2, it can be seen that the skin care composition of the present invention achieves more desirable anti-allergic effects by further optimizing the formulation system of the skin care composition. As can be seen from the comparison between examples 1-3 and comparative examples 1-6, the skin care composition has better anti-allergic effect when the raw materials are used together and the weight parts are within the range of the invention, which shows that the components of the skin care composition have synergistic effect.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 4.1 is provided, which is distinguished from example 3 by the following: adjusting the weight part of the glycolic acid to 2.5 parts;
comparative example 4.2 is provided, which is distinguished from example 3 by the following: adjusting the weight part of macromolecular salicylic acid to 0.5 part;
comparative example 4.3 is provided, which comparative example 4.3 differs from example 3 in that: adjusting the weight portion of the dianthus chinensis to 0.003 portion;
comparative example 4.4 is provided, which is distinguished from example 3 by the following: adjusting the weight part of sodium hydroxide to 1 part;
comparative example 4.5 is provided, which is different from example 3 in that: adjusting the weight part of the hydroxyethyl cellulose to 0.1 part;
skin care compositions prepared in conjunction with the preparation method of the present invention were tested according to the test method of experiment 3. The skin care compositions prepared in comparative example 4.1, comparative example 4.2, comparative example 4.3, comparative example 4.4, and comparative example 4.5 were evaluated for anti-allergic effects. The results were similar to those in comparative example 4 above.
Likewise, to further illustrate the beneficial effects of the present invention, the following comparative examples are provided:
comparative example 5.1 is provided, which comparative example 5.1 differs from example 3 in that: adjusting the weight part of the glycolic acid to 6 parts;
comparative example 5.2 is provided, which comparative example 5.2 differs from example 3 in that: adjusting the weight part of macromolecular salicylic acid to 4 parts;
comparative example 5.3 is provided, which comparative example 5.3 differs from example 3 in that: adjusting the weight portion of the dianthus chinensis to 0.05 portion;
comparative example 5.4 is provided, which comparative example 5.4 differs from example 3 in that: adjusting the weight part of sodium hydroxide to 1.5 parts;
comparative example 5.5 is provided, which comparative example 5.5 differs from example 3 in that: adjusting the weight part of the hydroxyethyl cellulose to 1 part;
skin care compositions prepared in conjunction with the preparation method of the present invention were tested according to the test method of experiment 3. The skin care compositions prepared in comparative example 5.1, comparative example 5.2, comparative example 5.3, comparative example 5.4, and comparative example 5.5 were evaluated for anti-allergic effects. The results were similar to those in comparative example 5 described above.
Experiment 4: stability test
And (3) testing a sample: the samples prepared in inventive examples 1-3 and comparative examples 1-6.
The experimental method comprises the following steps:
the tested samples are tested for 15 days, 30 days and 40 days under four test conditions of-18 ℃, room temperature, 45 ℃ and-18-45 ℃ alternately, and the tested samples are observed to have obvious change, pass or fail, and the test results are shown in the following table 5.
Table 5 stability test results
From the above results, it can be seen that:
after the skin care composition is tested for 15 days, 30 days and 40 days under four test conditions of-18 ℃, room temperature, 45 ℃ and-18-45 ℃ alternately, the skin care composition has no obvious change, and the test results are all qualified, namely the skin care composition has good cold resistance and heat resistance and can meet the use requirements under the condition of extreme temperature change. The skin care composition without the formulation system of the invention has poor cold resistance or heat resistance under long-term storage conditions, and cannot meet the use requirements under the condition of extreme temperature change.
It is to be understood that the invention disclosed is not limited to the particular methodology, protocols, and materials described, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims.
Those skilled in the art will also recognize, or be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.
Claims (3)
1. A skin care composition comprising glycolic acid, mandelic acid, macromolecular salicylic acid, hydroxyphenylpropionamide benzoic acid, dianthus chinensis, vitamin B6, 3-O-ethyl ascorbic acid, propylene glycol, hydroxyethyl cellulose, sodium hydroxide; wherein,
the weight portion of the glycolic acid is 3-5;
the weight part of the mandelic acid is 1-3;
the weight portion of the macromolecular salicylic acid is 1-3
The weight portion of the hydroxyphenylpropionamide benzoic acid is 0.005-0.1;
the weight portion of the caryophyllin is 0.005-0.01;
the weight portion of the vitamin B6 is 0.1-1;
the weight portion of the 3-O-ethyl ascorbic acid is 1.5-3;
the weight portion of the propylene glycol is 10-15;
the weight portion of the hydroxyethyl cellulose is 0.2-0.5;
the weight portion of the sodium hydroxide is 1.2-1.3;
and wherein the skin care composition is prepared by a process comprising the steps of:
s1, weighing propylene glycol, hydroxyethyl cellulose and water, adding the propylene glycol, the hydroxyethyl cellulose and the water into a container, uniformly stirring, heating to 75-80 ℃, uniformly stirring, and cooling to below 45 ℃;
s2, weighing glycolic acid, mandelic acid and sodium hydroxide, adding into the mixed solution obtained in S1, and uniformly stirring;
s3, weighing caryophyllin, ethoxy diglycol and propylene glycol, adding into the mixed solution obtained in the step S2, and uniformly stirring;
s4, weighing vitamin B6, 3-O-ethyl ascorbic acid, hydroxyphenyl propionamide benzoic acid and macromolecular salicylic acid, sequentially adding the weighed materials into the mixed liquid obtained in the step S3, and uniformly stirring.
2. A skin care product comprising the composition of claim 1.
3. Use of the composition of claim 1 in the preparation of a skin care product or a pharmaceutical composition.
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