CN110554181B - A reagent kit and a reagent disk device - Google Patents
A reagent kit and a reagent disk device Download PDFInfo
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- CN110554181B CN110554181B CN201810542650.7A CN201810542650A CN110554181B CN 110554181 B CN110554181 B CN 110554181B CN 201810542650 A CN201810542650 A CN 201810542650A CN 110554181 B CN110554181 B CN 110554181B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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Abstract
The invention discloses a reagent kit and a reagent disk device, wherein the reagent kit comprises a reagent kit main body which is detachably connected to a reagent disk matched with the reagent kit main body, and comprises a first reagent bottle area and a second reagent containing area, wherein the first reagent bottle area is provided with a first reagent bottle matching round hole on a first dividing circle, and the second reagent containing area is provided with a plurality of second reagent containing cavities on a second dividing circle. By the mode, the sucking action flow of the sample to be detected can be simplified.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a kit and a reagent disk device.
Background
The medical reagent analyzer is an instrument for detecting and analyzing samples, and can provide important data support for the diagnosis, treatment and prevention processes of diseases.
The existing medical reagent analyzer generally comprises a reagent box part and a reagent box tray matched with the reagent box, the reagent box generally comprises a plurality of reagent samples to be detected, and correspondingly, the sample sucking needle needs to move for a plurality of times along the radial direction to suck the samples in different reagent bottles respectively, so that the action flow is complex.
The inventor of the application provides a novel kit and a reagent disk device, which can simplify the action flow of a sample suction needle.
Disclosure of Invention
The invention mainly solves the technical problem of providing a kit and a reagent disk device, which can simplify the sucking action flow of a medical analyzer to a sample to be detected.
In order to solve the technical problems, the invention adopts a technical scheme that a kit is provided.
Wherein, this kit includes:
The kit comprises a kit main body, wherein the kit main body is detachably connected to a reagent disk assembly matched with the kit main body, the kit main body comprises a first reagent bottle area and a second reagent containing area, the first reagent bottle area is provided with a first reagent bottle assembly round hole on a first dividing circle, and the second reagent containing area is provided with a plurality of second reagent containing cavities on a second dividing circle.
In order to solve the technical problems, the invention adopts another technical scheme that a reagent disk device is provided.
Wherein, this reagent dish device includes:
A plurality of the reagent boxes and a reagent disk for assembling a plurality of the reagent boxes, wherein the reagent disk is detachably connected with the reagent boxes.
The invention has the advantages that the first reagent bottle region is arranged on the first dividing circle, the second reagent containing region comprising a plurality of second reagent containing cavities is arranged on the second dividing circle, and the sampling needle only needs to move from the first dividing circle to the second dividing circle in the radial direction in the sampling process. When samples to be detected in the second reagent accommodating cavities on the same dividing circle are sampled, the reagent box main body only needs to be moved circumferentially, so that the movement time sequence in the sampling process can be effectively reduced.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the description of the embodiments will be briefly described below, and it is apparent that the drawings in the following description are only some embodiments of the present invention, and other drawings may be obtained according to these drawings without inventive effort for a person skilled in the art. Wherein:
FIG. 1 is a schematic diagram of a kit according to an embodiment of the present invention;
FIG. 2 is a top view of the kit of FIG. 1 according to the present invention;
FIG. 3 is a schematic view of the structure of an embodiment of the first reagent bottle of the present invention;
FIG. 4 is a cross-sectional view of the first reagent bottle of FIG. 3;
FIG. 5 is a schematic view of the structure of an embodiment of a reagent disk device according to the present invention;
FIG. 6 is a schematic diagram of an embodiment of a reagent disk assembly according to the present invention;
FIG. 7 is a schematic diagram of an embodiment of the reagent disk of FIG. 6.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1 and 2, fig. 1 is a schematic structural diagram of an embodiment of a kit, and fig. 2 is a top view of the kit of fig. 1 according to the present invention, where the kit includes:
The kit body detachably connected to a reagent disk matched with the kit body comprises a first reagent bottle region 100 and a second reagent bottle region 200, wherein the first reagent bottle region 100 is provided with a first reagent bottle assembly round hole 110 on a first dividing circle, and the second reagent bottle region 200 is provided with a plurality of second reagent containing cavities 210 on a second dividing circle.
In this embodiment, by disposing the first reagent bottle region 100 on the first pitch circle, the second reagent holding region 200 including the plurality of the second reagent holding chambers 210 is disposed on the second pitch circle, and the sampling needle only has to be moved from the first pitch circle to the second pitch circle in the radial direction during sampling. When samples to be detected in the second reagent accommodating cavities on the same dividing circle are sampled, the reagent box main body only needs to be moved circumferentially, so that the movement time sequence in the sampling process can be effectively reduced.
In one embodiment, the kit further includes a first reagent bottle 120 accommodated in the first reagent bottle accommodating circular hole 110, and a second reagent accommodating chamber 210 for accommodating a reagent. The first reference circle and the second reference circle are respectively provided with a first sampling port and a second sampling port, and a plurality of second reagent bottles are aligned to the second sampling ports at the second reference circle position for sampling by rotating the reagent disk matched with the reagent box main body.
Further, since the external shape of the kit body is rectangular or fan-shaped, in one embodiment, the external shape of the kit body is fan-shaped, at this time, the first reagent bottle region 100 is located near the center of the fan-shaped, and the second reagent bottle region 200 is located far from the center of the fan-shaped. Therefore, the space of the reagent disk can be fully utilized, a plurality of reagent boxes can be conveniently accommodated on one reagent disk, and the detection efficiency is further improved.
In another embodiment, the number of the second reagent bottle accommodating chambers 210 is plural, for example, 3, 4, 6, 8, etc., which can be set according to the structure of the detector and the needs of the user, thereby being beneficial to better meeting the detection needs. In one embodiment, the number of the second reagent holding chambers 210 is 4.
In one embodiment, the first reagent bottle area 100 is provided with circular concave surfaces 130 on each side, and when the reagent kit is assembled into the reagent disk, two circular concave surfaces 130 are matched with convex surfaces of any two adjacent guide posts for positioning provided on the reagent disk assembly. Because the circular arc concave surface 130 is matched with the convex surface of the guide post, the reagent box is clamped between the adjacent guide posts, so that the installation of the reagent box on the reagent disk is facilitated, and the operation efficiency is improved.
Further, the first reagent bottle region 100 is provided with annular grooves 140 at the bottoms of the two circular arc concave surfaces 130, respectively, and the annular grooves 140 are snapped into annular protrusions provided at the bottoms of the guide posts. The annular groove 140 is clamped in the annular protrusion at the bottom of the guide post, so that the kit can be reliably positioned, and the kit is prevented from moving circumferentially in the rotating process.
Further, the bottoms of both sides of the second reagent holding area 200 are respectively provided with a first positioning boundary 230, and when the reagent kit is assembled into the reagent tray, two first positioning boundaries 230 are matched with the second positioning boundaries of any two adjacent limiting blocks for positioning arranged on the reagent tray assembly. The stopper is disposed at the outer periphery of the reagent disk, and prevents the second reagent accommodating area 200 of the reagent kit from moving circumferentially during the rotation process by engaging the second reagent accommodating area 200 of the reagent kit at the first positioning boundary 230, so that the mixing process of the reagent to be detected is more reliable and efficient.
In the present embodiment, the first reagent bottle region 100 and the second reagent containing region 200 of the reagent cartridge are engaged with each other by the guide post and the stopper, respectively, so that the reagent bottle can be firmly fixed.
In another embodiment, the kit further comprises a kit cover plate 240 disposed on top of the plurality of second reagent containing chambers 210 such that the plurality of second reagent containing chambers 210 are integral with the kit cover plate 240. Specifically, the reagent kit cover 240 is fixedly connected to the boundaries of the plurality of second reagent accommodating chambers 210 by ultrasonic welding.
In one embodiment, the kit further comprises a plurality of second silicone sleeves 250 covering the openings of the second reagent accommodating chambers 210, and the second silicone sleeves 250 are fixed at the openings of the second reagent accommodating chambers 210 by using a hot melting process. The opening is covered with aluminum foil to seal the second reagent holding chamber 210. Furthermore, the second silica gel sleeve 250 is further provided with a plurality of cross notches, so that the insertion of the sampling needle is facilitated, and the volatilization of the reagent can be slowed down.
Further, the second reagent holding area 200 is provided with cleats 260 on both sides. The anti-slip protrusion 260 is disposed at the opening of the second reagent holding area 200 near the second reagent holding cavity 210, which can increase the friction coefficient and prevent the reagent kit from slipping down during the process of grabbing and placing the reagent kit by an operator. The number of the cleats 260 is plural, and each of the cleats 260 is cylindrical in shape.
In another embodiment, please refer to fig. 1,3 and 4, fig. 3 is a schematic structural diagram of an embodiment of a first reagent bottle in the present invention, fig. 4 is a cross-sectional view of the first reagent bottle in fig. 3, the first reagent bottle 120 includes a first reagent bottle body 211, a first reagent bottle mouth 122 and a first reagent bottle bottom 123 respectively disposed at two ends of the first reagent bottle body 121, and an outer diameter of the first reagent bottle mouth 122 is larger than an inner diameter of the first reagent bottle accommodating cavity 110, so as to facilitate placement and removal of the first reagent bottle 120. Further, the first reagent bottle 120 is a fluorescent reagent bottle, at least one rib 124 is disposed in the first reagent bottle 120, and the rib 124 is disposed on the first reagent bottle body 121 and has the same extending direction as the first reagent bottle body 121, and is used for promoting the turbulence of the sample to be detected and improving the mixing uniformity of the sample to be detected in the process that the sample to be detected in the first reagent bottle 120 rotates along with the first reagent bottle 120.
Further, the first reagent bottle 120 further includes a first silica gel sleeve 150 covering the opening of the first reagent bottle, the first silica gel sleeve 150 is fixed on the opening of the first reagent bottle by using a hot melting process, and the opening is covered with aluminum foil to seal the first reagent bottle 120. Furthermore, the first silica gel sleeve 150 is further provided with a cross incision, so that the insertion of the sampling needle is facilitated, and the volatilization of the reagent can be slowed down.
In another embodiment, the reagent disk drives the reagent disk and the reagent box to rotate under the driving of the motor in the using process of the reagent box. The first reagent bottle bottom 123 is provided with a transmission part 125 for receiving the power from the driven gear on the reagent disk and driving the first reagent bottle 120 to rotate. Therefore, the kit also rotates while revolving along with the reagent disk to form a planetary gear train structure, so that the kit and the sample to be detected in the kit are more uniformly mixed, and the accuracy of the detection result is improved.
In order to solve the technical problems, the invention adopts another technical scheme that a reagent disk device is provided.
Referring to fig. 5 and 6, fig. 5 is a schematic structural view of an embodiment of a reagent disk device according to the present invention, and fig. 6 is a schematic structural view of an embodiment of a reagent disk assembly according to the present invention, wherein the reagent disk device comprises:
A plurality of the reagent kits 10 and a reagent disk 20 for assembling a plurality of the reagent kits 10, the reagent disk 20 being detachably connected with the reagent kits 10. Further, the reagent disk 20 includes a plurality of reagent cartridge positioning devices (not shown) detachably connected to the reagent cartridges 10 for fixing a plurality of the reagent cartridges 10. Further, the reagent disk assembly of fig. 5 includes the reagent disk 20 and one of the reagent cartridges 10 mounted on the reagent disk 20.
In one embodiment, referring to fig. 7, fig. 7 is a schematic structural diagram of an embodiment of the reagent disk in fig. 6, the reagent disk 20 further includes a fixed motor (not shown) and a fixed gear 21 disposed at a central position of the reagent disk, and the reagent cartridge positioning device includes a guide post 22 fixedly disposed at an outer periphery of the fixed gear 21, a driven gear 23 disposed between adjacent guide posts 22 and engaged with the fixed gear 21, and a stopper 24 disposed at an outer periphery of the reagent disk 20 and corresponding to the guide post 22. Further, the motor drives the reagent disk 20 to rotate, and the fixed gear 21 is fixed. The driven gear 23 revolves and moves relative to the fixed gear 21, so that the driving part 125 of the first reagent bottle bottom 123 is driven to realize the rotation of the first reagent bottle 120.
In one embodiment, referring to fig. 7, when the circular arc concave surfaces 130 are respectively disposed on two sides of the first reagent bottle region 100 of the reagent kit, a plurality of guide posts 22 for positioning are correspondingly disposed on the reagent tray at intervals along the first circumferential direction, and the convex surfaces of any two adjacent guide posts 22 are matched with two circular arc concave surfaces 130, wherein the guide posts 22 comprise a cylindrical sub-member 221 fixedly connected with the reagent tray and a conical sub-member 222 disposed on the cylindrical sub-member 221. The end of the tapered surface sub-member 222 remote from the cylindrical surface sub-member 221 is pointed to facilitate insertion of the kit.
Further, when the first reagent bottle region 100 is provided with the annular grooves 140 at the bottoms of the two circular arc concave surfaces 130, the bottom of the guide post 22 is correspondingly provided with the annular protrusion 223, the annular groove 140 can be clamped into the annular protrusion 223, and the annular groove 120 is clamped into the annular protrusion 223 at the bottom of the guide post 22, so that the reagent kit can be reliably positioned, and the reagent kit is prevented from moving circumferentially in the rotating process.
Further, when the bottoms of both sides of the second reagent receiving area 200 are respectively provided with the first positioning boundaries 230, the reagent tray is correspondingly provided with a plurality of stoppers 24 for positioning along the second circumferential direction at intervals, each stopper 24 has a second positioning boundary (not shown), and two of the first positioning boundaries 230 are matched with the second positioning boundaries of any two adjacent stoppers 24. The stopper 24 is disposed at the outer periphery of the reagent disk, and engages the second reagent accommodating area 200 of the reagent kit at the first positioning boundary 230 to prevent the second reagent accommodating area 200 of the reagent kit from moving circumferentially during the rotation process, so that the mixing process of the reagent to be detected is more reliable and efficient.
In the present embodiment, the first reagent bottle region 100 and the second reagent storage region 200 of the reagent cartridge are engaged with each other by the guide post 22 and the stopper 24, respectively, so that the reagent cartridge can be firmly fixed.
In addition, the kit and the reagent disk device disclosed by the invention are used for medical reagent analyzers, in particular to a chemiluminescent analyzer, and further, the chemiluminescent analyzer is a chemiluminescent immunoassay analyzer.
In summary, the invention discloses a reagent kit and a reagent disk device, wherein the reagent kit comprises a reagent kit main body which is detachably connected to a reagent disk assembly matched with the reagent kit main body, and comprises a first reagent bottle area and a second reagent containing area, wherein the first reagent bottle area is provided with a first reagent bottle distribution round hole on a first dividing circle, and the second reagent containing area is provided with a plurality of second reagent containing cavities on a second dividing circle. Through the mode, the invention can simplify the sucking action flow of the medical analyzer to the sample to be detected.
The foregoing description is only of embodiments of the present invention, and is not intended to limit the scope of the invention, and all equivalent structures or equivalent processes using the descriptions and the drawings of the present invention or directly or indirectly applied to other related technical fields are included in the scope of the present invention.
Claims (8)
1.A kit is characterized in that, the kit comprises:
The kit comprises a kit main body, a kit control device and a kit control device, wherein the kit main body is detachably connected to a reagent disk matched with the kit main body and comprises a first reagent bottle area and a second reagent bottle area, the first reagent bottle area is provided with a first reagent bottle assembly round hole on a first dividing circle, and the second reagent bottle area is provided with a plurality of second reagent accommodating cavities on a second dividing circle;
The two sides of the first reagent bottle area are respectively provided with an arc concave surface, and when the reagent kit is assembled into the reagent disk, the two arc concave surfaces are matched with the convex surfaces of any two adjacent guide columns arranged on the reagent disk assembly for positioning; annular grooves are respectively formed in the bottoms of the two circular arc concave surfaces, annular protrusions are correspondingly arranged at the bottoms of the guide posts, and the annular grooves are clamped in the annular protrusions at the bottoms of the guide posts to position the reagent box and limit circumferential movement of the reagent box in the rotating process;
The bottoms of two sides of the second reagent bottle area are respectively provided with a first positioning boundary, when the reagent kit is assembled into the reagent disk, a plurality of limiting blocks for positioning are correspondingly arranged on the reagent disk at intervals along the second circumferential direction, and the two first positioning boundaries are matched with the second positioning boundaries of any two adjacent limiting blocks for positioning arranged on the reagent disk assembly; the limiting block is arranged at the periphery of the reagent disk, and is used for clamping the second reagent bottle area of the reagent box at the first positioning boundary so as to limit the circumferential movement of the second reagent bottle area of the reagent box in the rotating process;
The novel reagent bottle is characterized in that at least one rib is arranged in the first reagent bottle, and the rib is arranged on the first reagent bottle body and is identical to the extending direction of the first reagent bottle body and is used for enabling a sample to be detected in the first reagent bottle to generate turbulence along with the rotation of the first reagent bottle.
2. The kit of claim 1, wherein the kit body has a fan shape, the first reagent bottle region is located near a center of the fan shape, and the second reagent bottle region is located far from the center of the fan shape.
3. The kit of claim 1, wherein the number of second reagent receiving chambers is 4.
4. The kit according to claim 1, the kit is characterized by further comprising:
The kit cover plate is covered on the top of the plurality of second reagent accommodating cavities and is provided with a plurality of corresponding second reagent sampling ports.
5. The kit according to claim 4, further comprising a first reagent bottle fitted in the first reagent bottle fitting hole, a first silica gel cover provided on a mouth of the first reagent accommodating chamber and a plurality of second silica gel covers provided on an opening of the second reagent accommodating chamber.
6. The kit of claim 1, wherein the second reagent bottle region is provided with cleats on both sides.
7. The reagent disk device is characterized by comprising a plurality of reagent boxes and reagent disks for assembling the plurality of reagent boxes according to any one of claims 1-6, wherein the reagent disks are detachably connected with the reagent boxes, when arc concave surfaces are respectively arranged on two sides of a first reagent bottle area of the reagent boxes, a plurality of guide posts for positioning are correspondingly arranged on the reagent disks at intervals along a first circumferential direction, the convex surfaces of any two adjacent guide posts are matched with the two arc concave surfaces, annular grooves are respectively arranged at the bottoms of the two arc concave surfaces, annular protrusions are correspondingly arranged at the bottoms of the guide posts, and the annular grooves are clamped in the annular protrusions at the bottoms of the guide posts to position the reagent boxes and limit the circumferential movement of the reagent boxes in the rotating process;
The reagent tray is correspondingly provided with a plurality of limiting blocks used for positioning along a second circumferential direction at intervals when the reagent box is assembled into the reagent tray, the two first positioning boundaries are matched with the second positioning boundaries of any two adjacent limiting blocks used for positioning arranged on the reagent tray assembly, when the bottoms of the two sides of the second reagent bottle area are respectively provided with the first positioning boundaries, the reagent tray is correspondingly provided with a plurality of limiting blocks used for positioning along the second circumferential direction at intervals, each limiting block is provided with a second positioning boundary, the two first positioning boundaries are matched with the second positioning boundaries of any two adjacent limiting blocks, the limiting blocks are arranged at the periphery of the reagent tray, and the first positioning boundaries are used for clamping the second reagent bottle area of the reagent box so as to limit the circumferential movement of the second reagent bottle area of the reagent box in the rotating process;
The novel reagent bottle is characterized in that at least one rib is arranged in the first reagent bottle, and the rib is arranged on the first reagent bottle body and is identical to the extending direction of the first reagent bottle body and is used for enabling a sample to be detected in the first reagent bottle to generate turbulence along with the rotation of the first reagent bottle.
8. The reagent disk device according to claim 7, wherein the reagent disk includes a reagent cartridge positioning device for fixing a plurality of the reagent cartridges, the reagent cartridge positioning device being detachably connected to the reagent cartridge.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810542650.7A CN110554181B (en) | 2018-05-30 | 2018-05-30 | A reagent kit and a reagent disk device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810542650.7A CN110554181B (en) | 2018-05-30 | 2018-05-30 | A reagent kit and a reagent disk device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN110554181A CN110554181A (en) | 2019-12-10 |
| CN110554181B true CN110554181B (en) | 2025-02-14 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201810542650.7A Active CN110554181B (en) | 2018-05-30 | 2018-05-30 | A reagent kit and a reagent disk device |
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| CN (1) | CN110554181B (en) |
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| CN113804674A (en) * | 2021-09-18 | 2021-12-17 | 广州蓝勃生物科技有限公司 | Reagent frame and chemiluminescence immunoassay appearance |
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