CN205333666U - Reagent mixing conveyer - Google Patents

Abstract

The utility model provides a reagent mixing and conveying device, including a driving device, a transport device and a rotating part, wherein the transport device includes a transport mechanism for transporting a reagent kit and a mixing mechanism for mixing the reagent, the driving device drives the transport mechanism and the mixing mechanism to produce relative motion, the rotating part and the mixing mechanism are matched with each other in a transmission, and the transport mechanism and the mixing mechanism are mutually sleeved together to form a bearing structure. In the process of transporting the reagent kit to the reagent collection position of the analyzer, the mixing device mixes the magnetic particle reagent by means of transmission matching, and has an ingenious structure, high reliability of the whole machine operation, and low manufacturing cost.

Description

Reagent Mixing Conveyor

technical field

The utility model relates to a reagent mixing device, in particular to a reagent mixing and conveying device for a chemiluminescence immunoassay analyzer.

Background technique

The automatic detection analyzer can automatically complete a series of operation steps from sample addition, reagent addition, reaction, detection, and detection results. It has become very common to use automatic detection analyzers to determine the content of a certain component in the tested sample. For example, a fully automatic chemiluminescence immunoassay analyzer includes a sample chamber, a reagent chamber, a reaction chamber and a detection chamber. The detection process of the analyzer roughly includes: first put the sample and reagent into the sample chamber and the reagent chamber respectively, then add the sample and reagent into the cuvette, then let the cuvette go through the incubation, separation, cleaning and other systems respectively, and finally use The reaction cup enters a closed dark room to complete the measurement.

Chemiluminescence immunoassay (CLIA) is a combination of highly sensitive chemiluminescence assay technology and a highly specific immune response to quantitatively detect various antigens, haptens, antibodies, hormones, enzymes, fatty acids, vitamins and Analytical techniques for pharmaceuticals, etc. Various reagents are required in chemiluminescence immunoassay, including solid-phase reagents, and commonly used solid-phase reagents are labeled magnetic particles. When used, the concentration of the magnetic particle reagent is required to be evenly distributed, and the magnetic particle is easy to precipitate under the action of gravity, resulting in inhomogeneity. If the magnetic particle reagent is precipitated and then participates in related reactions, the stability and reliability of the test results will be seriously affected. Therefore, it is necessary to mix the magnetic particle reagent before using it.

The current fully automatic chemiluminescent immunoassay analyzer uses a stirring mechanism to stir and mix the magnetic particle reagents, but this method not only takes a long time to mix, the effect is poor, and it is very easy to form cross-contamination. However, mixing magnetic particle reagents with high-frequency throughput or shaking methods cannot meet the requirements of simultaneous mixing of magnetic particle reagents in multiple kits, and will reduce the detection speed of the automatic analyzer. In the method of mixing the magnetic particle reagent with transmission, the analysis instrument includes a reagent box conveying part and a magnetic particle reagent mixing part. The automatic analyzer will transport the corresponding reagent box to the reagent collection position of the analyzer through the transmission part according to the needs of the test items. During the process of transporting the reagent box, the mixing part will mix the magnetic particle reagent evenly by means of transmission and cooperation. . However, in the existing design, the conveying part and the mixing part belong to independent operating systems. These relatively independent and dispersed structures will reduce the operation accuracy and reliability of the analyzer, and increase the complexity of the analyzer assembly and the manufacturing cost. The complex and diverse modules of the mechanical structure will also increase the volume of the analyzer itself, making the analyzer very bulky and requiring more laboratory space.

In existing fully automatic detection analyzers, the cooperation between the reagent box and the reagent box bracket usually requires complex matching structural parts such as hooks to maintain the position of the reagent box on the reagent box bracket. Therefore, it is not only time-consuming but also expensive in the process of manufacturing the kits and kit racks. The structure between the kit and the bracket is not compact and the volume is large. Mechanical noise will be generated between the assembled parts, which will affect the detection accuracy of the analyzer and increase the difficulty and cost of subsequent maintenance.

In the field of detection and analysis, it is often necessary to use multiple reagents to complete the detection of a project. When using a fully automatic detection analyzer to detect items, a variety of reagents will be collected in a kit, and the kit will be put into the fully automatic analyzer. There are multiple reagent bottle storage chambers in the reagent box, and different reagents are packed in different reagent bottles. These reagent bottles with reagents are pre-loaded into the kit storage cavity.

When detecting different items, it is necessary to replace the reagent box in the analyzer. Or the reagent in the kit is used up, and the kit needs to be replaced. Using a test box without a handle, the operator must grasp the body of the test box to take it out. If the reagent boxes are tightly arranged in the analyzer, that is, the reagent boxes are next to each other, there is not much room for the operator to grab the reagent boxes with fingers, which makes it very inconvenient to take out the reagent boxes. And some kits will add an additional handle, although it is very convenient for the operator to take out the kit, but due to the existence of the handle, it needs to occupy a certain space of the instrument and increase the overall volume of the instrument. This not only increases the material cost of the instrument, but also takes up more laboratory space.

According to the needs of medical testing, sometimes a sample needs to complete multiple testing items. For example, to analyze whether a patient has a certain infectious disease, it is necessary to perform HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, HCV, HSV-I, HSV-II, RV, HCMV and TOXO, Chlamydia, Detection items for Gonorrhea, HIV, Syphilis, etc. To analyze whether there are tumor markers in patient samples, it is necessary to detect, for example, PSA, Cyfra21-1, AFP, CEA, NSE, CA19-9, CA15-3, CA72-4, CA125, CA50, ProGRP, Fer, TPS, GPC3, etc. In order to know whether the subject has drug abuse, the required test items include MOP, AMP, BAR, COC, MET, THC, BZO, MDMA, MTD, OPI, PCP, etc. Different detection items require different detection reagents. Therefore, it is required that the reagent compartment in the fully automatic analyzer can be filled with enough reagent boxes at one time to meet the detection requirements. If there are not enough storage places for the reagent boxes in the reagent warehouse, it will cause the same detection series, such as infectious disease series detection, it is necessary to put the corresponding detection item kits into the analyzer in batches to complete the detection in batches. First put the kits for detecting HBsAg, HBsAb, HBeAg, HBeAb, HBcAb, HCV, Chlamydia, and Gonorrhea into the analyzer. At this time, the kit storage space in the reagent chamber of the analyzer is full, and then start the detection. After the first batch of project testing is completed, take out the first batch of kits used, and then put in the detection reagents of HSV-I, HSV-II, RV, HCMV, TOXO, Chlamydia, Gonorrhea, HIV, and Syphilis in the ToRCH series box. This affects the progress of analytical testing.

Utility model content

In order to solve the problems existing in the prior art, the utility model provides a reagent mixing and conveying device, which includes a driving device, a transfer device and a rotating part. Mechanism, the driving device drives the conveying mechanism and the mixing mechanism to produce relative motion, the rotating part is installed on the reagent bottle, and the rotating part and the mixing mechanism are driven and coordinated, and the conveying mechanism and the mixing mechanism are nested together to form a bearing structure .

Further, the conveying mechanism and the mixing mechanism are ring structures, and the conveying mechanism is arranged in the central hole of the mixing mechanism.

Further, the driving device includes a driving motor and a driving end, and the driving end is arranged in the central hole of the transport mechanism.

Further, the transmission mode between the driving end and the conveying mechanism is selected from gear meshing transmission, friction transmission, and pulley transmission; the transmission mode between the mixing mechanism and the rotating member is selected from gear meshing transmission and friction transmission.

Further, the conveying mechanism is an internal gear structure, the mixing mechanism is an external gear structure, a driving rack is provided on the driving end, and the driving rack meshes with the internal gear of the conveying mechanism, the rotating part is a gear, and the The rotating member gear meshes with the external gear of the mixing mechanism.

Further, the conveying mechanism includes a base and a mounting base, the base and the mixing mechanism are connected together in a bearing manner, the mounting base is installed on the base, and the mounting base includes a transmission member that cooperates with the driving device.

The reagent mixing and conveying device described in the utility model is small in volume, ingenious in structure, simple and reliable, easy to assemble, high in operation reliability of the whole machine, and low in manufacturing cost. Moreover, the magnetic particle mixing method of the utility model is simple and reliable, has good mixing effect, has no risk of cross-contamination, and can simultaneously mix several magnetic particle reagents.

Description of drawings

Figure 1 is a schematic diagram of the separation of the kit body and the reagent bottle.

Figure 2 is a schematic diagram of the combination of the kit body and the reagent bottle.

Figure 3 is a schematic diagram of putting the kit into the kit bracket.

Fig. 4 is a schematic diagram of the cooperation between the misplaced positioning member and the positioning opening on the bracket.

Fig. 5 is a schematic diagram of the matching of the correspondingly arranged positioning elements with the positioning openings on the bracket.

Fig. 6 is a schematic diagram showing that only one side wall of the reagent box is provided with a positioning member to cooperate with the positioning opening of the bracket.

Fig. 7 is a top view of the protrusion being put into the kit box body along the clip channel.

Fig. 8 is a top view of the projection turned to under the eaves of the cover.

Fig. 9 is a partial view of the projection being put into the kit box body along the clip channel.

Figure 10 is a partial view of the projection turned to under the eaves of the cover.

Fig. 11 is a schematic diagram of cooperation between the L-shaped structural member on the reagent bottle and the concave structural member in the box body.

Fig. 12 is a schematic diagram of the fitting of the fastening part on the reagent bottle and the fastening groove inside the box body.

Fig. 13 is a schematic diagram of cooperation between the reagent storage device and the reagent mixing and conveying device.

Figure 14 is a schematic diagram of the reagent mixing and conveying device.

Figure 15 is a schematic diagram of the reagent mixing and conveying device.

Figure 16 Top view of the reagent compartment.

Fig. 17 is a cross-sectional view of the reagent chamber in the direction of Fig. 16A-A.

Fig. 18 is a schematic diagram of the reagent compartment put into the reagent kit.

Figure 19 is a schematic diagram of a reagent chamber with a refrigeration device.

Fig. 20 is a schematic diagram of the internal structure of the automatic chemiluminescence immunoassay analyzer.

Figure 21 is a schematic diagram of a fully automatic chemiluminescence immunoassay analyzer.

Figure 22 The fully automatic chemiluminescence immunoassay analyzer with the side baffle removed from the sample chamber.

detailed description

The utility model will be further described in detail below in conjunction with the accompanying drawings and embodiments, but the protection scope of the utility model is not limited thereto.

A fully automatic chemiluminescent immunoassay analyzer 9000, as shown in Figures 20 to 22, includes a sample compartment 9300, a reagent compartment 9400, a cuvette storage compartment 9500, an incubation compartment 9600, a cleaning compartment 9700 and a detection compartment 9800. When analyzing the components of the sample to be tested, the sample and the reagent are put into the sample compartment and the reagent compartment respectively, and the automatic chemiluminescence immunoassay analyzer takes out the cuvette from the cuvette storage compartment 9500 and puts it into the incubation compartment. Then add the samples and reagents into the cuvette according to the predetermined procedure, start the incubation procedure and the cleaning procedure, and finally let the cuvette enter the detection chamber to complete the analysis of the sample components. The sample chamber includes an identity information reading device, and the reagent chamber includes a reagent mixing and conveying device.

As shown in Figures 1 and 2, the reagent box 1 for storing detection reagents includes a box body 2 and a mixing chamber 3, and the mixing chamber 3 is used for storing reagents that need to be mixed during detection, and the reagents can be directly loaded Put it into the mixing chamber, or put it into the mixing chamber 3 after loading the reagent bottle in advance. If necessary, the reagent box can also include a storage chamber 4, which is used to store reagents that do not require high mixing during detection, and the reagents can be directly loaded into the storage chamber, or pre-loaded into reagent bottles Put it into the storage cavity 4 again.

In the embodiment shown in FIG. 1 , the reagent to be mixed is pre-loaded into a mixing reagent bottle 5 , and a rotating member 6 is arranged on the mixing reagent bottle 5 . The mixing reagent bottle 5 containing the reagent is put into the mixing chamber 3 of the kit, and the rotating member 6 drives the mixing reagent bottle 5 to rotate in the mixing chamber 2, so that the reagent in the reagent bottle 5 is rotated due to the rotation. In a state of suspension and mixing. The rotating part 6 can be a structure attached to the mixing reagent bottle 5, that is, the rotating part 6 itself has been installed on the reagent bottle 5 before the reagent bottle 5 is put into the mixing chamber as shown in FIG. 1 . The rotating part 6 can also be a separate part. After the mixing reagent bottle 5 is put into the mixing chamber 3, the mixing reagent bottle cooperates with the rotating part, so that the reagent bottle 5 and the rotating part 6 are assembled together. When the rotating part is used as a separate part, it can be installed on the reagent box, or be arranged on an instrument matched with the reagent box. In the embodiment shown in FIG. 2 , after the reagent bottle 5 is put into the mixing chamber 3 , the rotating member 6 is located at the notch 31 of the mixing chamber 3 .

A positioning port 104 is provided on the wall of the reagent box storage chamber and/or the mixing chamber, and a positioning member 7 is correspondingly provided on the tube wall of the reagent bottle 11 . Before putting the reagent bottle into the storage chamber and/or the mixing chamber, first align the reagent bottle positioning member 7 with the positioning port 104, and then let the reagent bottle go down into the storage chamber and/or the mixing chamber, so as to ensure that the reagent bottle Be accurately placed in the storage chamber and/or mixing chamber. The upper surface of the positioning member 7 is flush with the upper surface of the reagent bottle, and the depth of the positioning opening 104 is the same as the depth of the positioning member 7 . After the reagent bottle positioning member is inserted along the positioning opening, if the upper surface of the positioning member is flush with the upper surface of the positioning opening, it means that the reagent bottle has been accurately placed in place.

In another embodiment, the inner wall of the storage cavity further includes an elastic piece for clamping the reagent bottle placed in the storage cavity.

In the field of detection, such as chemiluminescent immunoassay, a variety of reagents are required to complete the detection of an item, including reagents with solid phases, such as reagents containing magnetic particles. Therefore, the reagent box with the mixing chamber 3 and multiple storage chambers 4 described in the present invention is selected, and the reagent containing magnetic particles is put into the mixing reagent bottle.

When testing, put the kit corresponding to the testing item into the analyzer. In one embodiment, the analyzer includes a reagent box bracket for carrying the reagent box, and according to the type of the detection item, the corresponding detection kit is put into the corresponding position of the reagent box bracket, so as to realize the Multiple items can be tested once started.

The kit bracket 100 shown in Figure 3 includes an inner ring 101 and a partition 102, the partition is installed on the inner ring, and a horizontal section is formed between the two partitions 102 to form a fan-shaped storage chamber 103 for the storage chamber. Place kit 1. In one embodiment, the number of storage chambers 103 is set in such a way that the reagent kit rack can accommodate the maximum number of reagent kits. Such a setting method can satisfy more testing items, and in a series of testing, there is no need to install the kit twice.

In one embodiment, a positioning opening 104 is provided on the upper edge of the partition 102 of the reagent box bracket, and a positioning member 7 is provided on the kit as shown in FIG. 2 corresponding to the positioning opening 104 of the partition. Before putting the kit into the storage chamber of the bracket, first align the positioning piece of the kit with the positioning opening, and then let the kit go down into the storage chamber, so as to ensure that the kit is accurately stored in the storage chamber 103, ensuring When collecting reagents during the detection process, the liquid collector of the analyzer can enter the reagent storage chamber or mixing chamber accurately, without the liquid collector touching the upper cover of the reagent box and damaging the liquid collector. In another embodiment, in order to reduce the weight of the analyzer, the storage cavity of the reagent box bracket is connected up and down, and the bottom of the storage cavity is not provided with a bottom plate for supporting the reagent box. Therefore, the mutual cooperation between the positioning member and the positioning opening has a supporting effect on the reagent box placed in the storage cavity 103 . The depth of the positioning member 7 is the same as the depth of the positioning port 104. When the reagent box is put into the storage chamber, if the upper surface of the positioning member is flush with the upper surface of the positioning port, it means that the reagent kit has been put in place and meets the requirements of the analyzer. running requirements. In the embodiment shown in FIGS. 1 to 3 , the upper surface 71 of the positioning member 7 is flush with the upper surface 8 of the reagent box, and the depth of the positioning opening 104 is the same as the depth of the positioning member 7 . After the kit positioning member is inserted along the positioning opening, if the upper surface 71 of the positioning member is flush with the upper surface of the positioning opening, it means that the reagent box has been put in place. The design that the upper surface 71 of the positioning member 7 is flush with the upper surface 8 of the reagent box allows the operator to more easily observe whether the reagent box is put in place.

In one embodiment, the positioning pieces on the two side walls of the kit are arranged in a staggered manner. Specifically, a positioning piece is provided on the first side wall of the reagent box, and the positioning piece on the second side wall of the reagent box is not arranged at a position corresponding to the positioning piece on the first side wall. To further illustrate, as shown in Figure 1, one side wall of the test kit includes a middle positioning member 72, and the other side wall of the test kit includes a left positioning member 73 and a right positioning member 74, and the left and right positioning members are respectively located in the middle positioning corresponding sides of the piece. As shown in Fig. 4, according to the method shown in this embodiment, three partitions 102 with the same arrangement of positioning openings 104 form two storage chambers 103, and two reagent boxes 1 with the same arrangement of positioning members are put into Behind the storage chamber, the two test kits are tightly leaned against the two sides of the same partition. The middle positioning piece 72 of the first reagent box and the left positioning piece 73' and the right positioning piece 74' of the second reagent box are matched with the positioning opening of the partition in a staggered manner. The left positioning part 73 and the right positioning part 74 of the first reagent box and the middle positioning part 72'' of the third reagent box are interlaced with each other to cooperate with the positioning opening of the partition. The middle locator 72' of the second kit is arranged in a staggered manner with the left and right locators of the fourth kit. Such a design scheme reduces the number of partitions used, thereby reducing the volume of the analyzer. Moreover, both side walls of the kit are supported by partitions, which ensures the storage stability of the kit in the storage cavity. Compared with the design shown in Fig. 5, the embodiment shown in Fig. 4 can save one spacer for the kit bracket for every two kits stored, thereby reducing the space occupied by the kit bracket and allowing the kit bracket to Fewer shelves and more space for more kits. The positioning members 7 on the two side walls of the reagent box shown in FIG. 5 are arranged corresponding to each other. When two reagent boxes are put into the storage cavity, four partitions 102 must be used. Compared with the design shown in Fig. 6, the embodiment shown in Fig. 4 has a more stable storage of the kit. As shown in FIG. 6 , in order to realize that the storage chamber composed of three partitions can accommodate two reagent boxes, the reagent boxes are only provided with a positioning member 7 on one side wall. After the test kit is put into the storage chamber 103, the side of the kit without the positioning piece is not supported by the partition 102, which makes it very unstable for the reagent kit to be placed in the storage chamber.

The inner ring of the kit bracket may also include a kit positioning guide groove 105, and a guide piece 9 is arranged on the kit. When the reagent box is put into the storage chamber, the guide member 9 is inserted into the guide groove 105 and moves down along the guide groove. The coordinated design of the guide groove and the guide allows the reagent box to be quickly and accurately placed into the storage cavity. In the embodiment shown in Figures 2 and 3, the guide groove 105 is located in the middle of the two partitions, and the guide 9 is located in the middle of the outer side of the narrow end of the reagent box. In another embodiment, a blocking block 10 is installed on the guide member, and the width of the blocking block is greater than the width of the notch of the guide groove. As shown in FIG. 3 , when the guide piece 9 is inserted into the guide groove, the blocking block 10 is located outside the guide groove 105 , further defining the position of the reagent box in the storage chamber.

The inner side of the inner ring of the reagent box bracket may further include a reinforcing wall 106, and the reinforced wall 106 further ensures the shape of the reagent box bracket, such as a circular shape. During the operation of the analyzer, the reagent box bracket with stable shape can ensure the accuracy of reagent sampling. After the kit is put into the storage cavity, the bottom of the blocking block 10 can also abut against the upper surface of the reinforcing wall 106 to further support the kit.

A reagent storage device for a fully automatic in vitro diagnostic analyzer includes the reagent box 1 and the reagent box bracket 100 described in the utility model. The kit rack includes storage chambers 103, and the number of the storage chambers 103 is set in such a way that the kit rack can accommodate a maximum number of reagent kits. The kit includes a reagent storage chamber 4 and/or a mixing chamber 3 . The number and volume of the storage chamber 4 and/or the mixing chamber 3 are set in such a way that the reagent box can accommodate the most types of reagents and/or the maximum reagent storage capacity. The kit shown in Figure 1 includes three circular reagent storage chambers 4 and one reagent mixing chamber 3 located at the narrow end of the kit. A storage chamber with a larger diameter is arranged in the middle of the kit, and two storage chambers with the same diameter are arranged side by side at the wide end of the kit. The outer edges of the storage cavity and the mixing cavity are tangent to the inner wall of the kit. In one embodiment, the storage cavity fills the entire cartridge.

In one embodiment, the horizontal sections of the storage cavity and the reagent box are fan-shaped. The combination of the number of storage cavities and the number of reagent storage cavities makes the amount of reagent that can be stored in the reagent storage device reach the maximum value of the amount of reagent that can be stored in the reagent storage device.

In one embodiment, the reagent bottle 11 includes a locking member, and the storage chamber 4 includes a blocking member. The blocking piece is used for blocking the card piece from leaving the storage cavity. When the stopper blocks the clip, when the reagent bottle is lifted, the kit body can be lifted together. Keep the balance of the whole box body, so as not to tilt and cause the danger of reagents pouring out.

In the embodiment shown in Fig. 1 and Figs. 7 to 10, the reagent box 1 includes a box body 2 and a storage chamber 4, the storage chamber is used for storing reagents or reagent bottles containing reagents. The reagent bottle 11 includes a clip, and the storage cavity 4 includes a blocking piece and a clip channel 12 . In one embodiment, the locking part is a protrusion 13 installed on the outer wall of the reagent bottle. The stopper is the cover eaves 14 of the box body loam cake, and the cover eaves belong to a part of the box body loam cake, and the cover eaves 14 are closer to the center of the storage cavity cross-section than the inner wall of the storage cavity 3 . The clip channel 12 is located at the upper cover and adjacent to the blocking member. The bump 13 enters or leaves the storage cavity through the clip channel 12 . As shown in Figures 7 and 9, when it is necessary to put the reagent bottle 11 into the box body 1, first align the protrusion 13 on the reagent bottle with the clip channel 12, and then put the reagent bottle down into the storage chamber. As shown in Figures 8 and 10, when the reagent bottle reaches the preset position, the reagent bottle is rotated, and the protrusion 13 (ie, the clip) on the reagent bottle is rotated to the underside of the cover eaves 14 (ie, the stopper). At this time, the reagent bottle cannot be separated from the box body. When the reagent bottle is lifted, the box body is also lifted together, and then the reagent box can be put into or taken out of the analytical instrument. When the reagent bottle is turned, the protrusion is turned to the channel 12 of the clip, so that the protrusion 13 is no longer located under the eaves 14, so that the reagent bottle can be removed from the box body. In a preferred solution, the tail end of the projection includes a stopper 131, and the height of the stopper is higher than the lower bottom surface of the eaves. When the projection is rotated to the bottom of the cover eaves, the stopper will not be able to pass through the cover eaves, so that it is determined that the projections have been turned in place.

In the embodiment shown in FIG. 11 , the locking member is an L-shaped structural member 15 , and the blocking member is an inverted concave structural member 16 . After the reagent bottle reaches the preset position, turn the reagent bottle and rotate the L-shaped structure 15 on the reagent bottle into the concave structure 16, so that the reagent bottle cannot leave the box body. While lifting the reagent bottle, the box body can be lifted together.

In the embodiment shown in FIG. 12 , the clamping part is a snap-fitting part, and the snap-fitting part includes an elastic clamping arm 17 and a clamping foot 18, and one end of the clamping arm 17 is installed on the outer wall of the reagent bottle. The blocking member is a fastening groove 19 . When putting the reagent bottle into the storage chamber, press the clamping arm 17 against the outer wall of the reagent bottle, and go down along the vertical plate 20 of the fastening groove 19 until the clamp foot 18 snaps into the fastening groove 19, and the vertical plate of the fastening part 20 prevents the clamping feet from moving upwards out of the storage cavity. When the reagent bottle needs to be replaced, the clamping arm 17 is pressed against the outer wall of the reagent bottle again to make the clamping foot 18 leave the fastening groove 19, so that the reagent bottle can be taken out from the box body.

The reagent mixing and conveying device includes a transfer device and a driving device. The transfer device includes a conveying mechanism 201 and a mixing mechanism 202. The conveying mechanism 201 and the mixing mechanism 202 are nested together to form a bearing structure. The delivery mechanism is used to place the reagent box and transport the reagent box to the corresponding position of the analyzer. The mixing mechanism 202 cooperates with the rotating member 6 and is used for mixing the reagents in the reagent box that need to be mixed. The driving device includes a driving end 301 and a power part 302 . The driving device drives the transport mechanism 201 and the mixing mechanism to generate relative motion, so as to generate a transmission between the rotating member 6 used for reagent mixing and the mixing mechanism 202, so as to realize the transfer and mixing of the detection reagent.

In the embodiment shown in Figures 13 to 17, the conveying mechanism 201 and the mixing mechanism 202 are ring structures, the conveying mechanism is arranged in the central hole of the mixing mechanism, and the two are assembled together to form a bearing structure. In the embodiment shown in FIG. 15 , a ball 203 is provided between the conveying mechanism 201 and the mixing mechanism 202 . The mixing mechanism is fixedly installed on the analyzer. The driving end 301 of the driving device is disposed in the central hole of the transport mechanism. In one embodiment, the conveying mechanism 201 is an internal gear structure, the mixing mechanism 202 is an external gear structure, a driving rack is arranged on the driving end 301, and the driving rack meshes with the internal gear of the conveying mechanism, and the power part 302 is motor. The mixing chamber of the reagent box shown in FIG. 2 includes a mixing reagent bottle 5 with a rotating part 6 at the bottom. The reagent bottle contains magnetic particle reagents that need to be mixed. The rotating part 6 is a gear structure. When the reagent box 1 is placed on the conveying mechanism 201 , the gear (rotating member) installed at the bottom of the reagent bottle and the external gear of the mixing mechanism 202 mesh with each other. Turn on the motor to rotate the driving end, and the driving end drives the transport mechanism to rotate, and the reagent box placed on the transport mechanism also rotates together, so that the gear and the external gear of the mixing mechanism generate transmission. The reagent bottle with a rotating part at the bottom rotates automatically under the meshing drive of the mixing mechanism and the rotating part, so that the reagents contained in the reagent bottle are mixed evenly due to the rotation. In this embodiment, the mixing mechanism is fixedly installed on the analyzer, the mixing mechanism cannot rotate, and the transport mechanism rotates around the central axis of the mixing mechanism. In another solution, the conveying mechanism and the mixing mechanism can also rotate relatively around the same central axis.

The transmission mode between the driving end 301 and the conveying mechanism 201 can also be selected from gear meshing transmission, friction transmission, pulley transmission and the like. The transmission mode between the mixing mechanism 202 and the rotating member 6 can also be self-gear meshing transmission, friction transmission and the like.

Assembling the conveying mechanism and the mixing mechanism in the form of a bearing structure can reduce the friction coefficient of the conveying mechanism and the mixing mechanism during the movement, reduce the mechanical noise during machine operation, reduce the energy consumption of the analyzer, and prolong the life of the analyzer. service life. Compared with the need to install the conveying mechanism and the mixing mechanism to the analyzer step by step in the prior art, the conveying mechanism and the mixing mechanism described in the utility model can be installed on the analyzer as a whole, which makes the installation and operation simple and convenient. Convenient and conducive to regular maintenance, cleaning and replacement. And it can effectively ensure that the horizontal planes of the conveying mechanism and the mixing mechanism are kept parallel to each other, thereby ensuring a stable positional relationship between the two, maintaining a high dynamic balance state, and improving the operating accuracy of the analyzer. In the long-term operation process, the cooperation between the rotating part and the mixing mechanism is stable, and the phenomenon of tooth beating is not easy to occur. The conveying mechanism and the mixing mechanism are assembled into a bearing structure, and the corresponding assembly parts on the analyzer will be reduced, thereby saving the installation space of the analyzer components. The driving end is installed in the center hole of the transport mechanism, making good use of the idle space of the analyzer, making the overall volume of the analyzer smaller.

In another embodiment, the mixing mechanism 202 is disposed in the central hole of the conveying mechanism 201, and the two are assembled together to form a bearing structure. The conveying mechanism 201 is an external gear structure, the mixing mechanism 202 is an internal gear structure, and the driving end is arranged on the outer side of the conveying mechanism.

In one embodiment, the conveying mechanism includes a base and a mounting base, the base is located in the central hole of the mixing mechanism, and is connected with the mixing mechanism in a bearing manner, and the mounting base is installed on the base, The mount is used to place the kit. The mounting seat includes a transmission part matched with the driving end. The driving end drives the mounting seat to rotate, and the mounting seat drives the transport mechanism to rotate relative to the mixing mechanism, and the reagent box placed on the mounting seat also rotates together, so that the rotating part and the mixing mechanism generate transmission. The reagent bottle with a rotating part at the bottom rotates automatically under the transmission of the mixing mechanism and the rotating part, so that the reagents contained in the reagent bottle are mixed evenly due to the rotation. In another embodiment, the conveying mechanism does not include a transmission member that cooperates with the driving end, and the mixing mechanism does not include a transmission member that cooperates with the rotating member, and the conveying mechanism and the mixing mechanism are assembled together to form a bearing structure. The transmission parts, such as gears and friction blocks, are installed as an independent component at corresponding positions of the conveying mechanism and the mixing mechanism.

The reagent chamber 400 of the automatic analyzer includes a reagent storage device and a reagent mixing and conveying device. The reagent mixing and conveying device includes a transfer device and a driving device. The transfer device includes a conveying mechanism 201 and a mixing mechanism 202. The conveying mechanism 201 and the mixing mechanism 202 are nested together to form a bearing structure. The reagent storage device includes a reagent box and a reagent box bracket. The reagent box bracket 100 is installed on the transport mechanism 201 , and the reagent box 1 is put into the reagent box bracket 100 . The rotating part 6 connected with the reagent bottle containing the mixing reagent cooperates with the transmission part of the mixing mechanism 202 . The driving device includes a driving end 301 and a power part 302 . When the reagent mixing and transporting device is in operation, the driving device drives the transport mechanism 201 to generate relative motion with the mixing mechanism to transport the reagent box to a position corresponding to the detection. At the same time, with the rotation of the conveying mechanism, a transmission is generated between the rotating part used for reagent mixing and the mixing mechanism, and the reagent bottle rotates in the kit under the transmission of the mixing mechanism and the rotating part, so that the reagent bottle is contained in the reagent bottle. The reagents were mixed by swirling.

The reagent compartment 400 shown in Figures 18-19 also includes a thermal insulation layer 401 and a compartment cover, so that the reagent compartment is in a relatively heat-retaining and airtight state. The heat preservation layer surrounds the reagent storage device therein, and keeps the reagent in the reagent chamber in a constant temperature state. The reagent compartment also includes a reagent compartment cooling device 403 for cooling the reagent compartment. In one embodiment, the cooling device is selected as a semiconductor cooling chip. In one embodiment, the cooling device is arranged at the bottom of the reagent compartment. The reagent chamber also includes a reagent bottle zero sensor 404 for judging the initial position of the reagent chamber.

A reagent mixing method for a full-automatic analyzer. Firstly, a reagent box containing a detection reagent is put into a reagent compartment, and placed on the reagent box bracket described in the utility model. The reagent box bracket cooperates with the reagent mixing and conveying device described in the utility model. When the reagent mixing and conveying device is running, the driving device of the automatic analyzer drives the transport mechanism 201 to generate relative motion with the mixing mechanism, and according to the needs of the testing items, the transport mechanism transports the corresponding reagent box to the reagent collection position of the analyzer . At the same time, with the rotation of the conveying mechanism, a transmission is generated between the rotating part used for reagent mixing and the mixing mechanism, and the reagent bottle rotates in the kit under the transmission of the mixing mechanism and the rotating part, so that the reagent bottle is contained in the reagent bottle. The reagents were mixed by swirling.

Claims (6)

1. reagent mixing transporter, including driving device, transporter and tumbler, transporter includes the mixing mechanism of conveyer and the mixing reagent transporting test kit, driving device drives conveyer to produce relative motion with mixing mechanism, tumbler is installed on reagent bottle, between tumbler and mixing mechanism, transmission coordinates, it is characterised in that described conveyer and mixing mechanism connect together composition bearing arrangement mutually。

2. reagent according to claim 1 mixing transporter, it is characterised in that conveyer and mixing mechanism are circular ring structure, and conveyer is arranged in the centre bore of mixing mechanism。

3. reagent according to claim 1 mixing transporter, it is characterised in that driving device includes drive motor and drive end, and drive end is arranged in the centre bore of conveyer。

4. reagent according to claim 3 mixing transporter, it is characterised in that the kind of drive between described drive end and conveyer is selected from meshed transmission gear, frictional drive, pulley drive；The kind of drive between mixing mechanism and tumbler is from meshed transmission gear, frictional drive。

5. reagent according to claim 3 mixing transporter, it is characterized in that, conveyer is inner gear structure, mixing mechanism is external gear structure, drive end is provided with driving tooth bar, the internal gear of described driving tooth bar and conveyer engages each other, and described tumbler is gear, and the external gear of described tumbler gear and mixing mechanism engages each other。

6. reagent according to claim 1 mixing transporter, it is characterized in that, conveyer includes pedestal and mounting seat, and pedestal and mixing mechanism interconnect in the way of bearing, mounting seat is arranged on described pedestal, and mounting seat includes the driving member coordinated with driving device。