CN110548077B - A medicinal composition for treating chronic pharyngitis and its preparation method and use - Google Patents
A medicinal composition for treating chronic pharyngitis and its preparation method and use Download PDFInfo
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Abstract
本发明提供了一种治疗慢性咽炎的药物组合物及其制备方法和用途。该药物组合物是由如下重量配比的原料药制备而成的制剂：罗汉果10～20份，乌梅10～20份，桔梗8～15份，甘草5～12份，蒲公英5～12份，胖大海5～10份，菊花5～10份，栀子5～10份，余甘子2～7份，青果2～7份。本发明药物组合物全部由药食同源的药物组成，提高了药物的安全性，增加了适用范围和人群。本发明药物组合物能够有效治疗慢性咽炎，对慢性咽炎所致的咽部不适感，如异物感、痒感、灼热感、干燥感和/或刺激感，以及咽部微痛、咽部咳嗽、伴随恶心感、咽部粘膜增厚，有黏稠或黏浓性分泌物等症状有明显的消除或缓解作用。同时，本发明药物组合物药味配伍精当，缺一不可，改变用药配比会影响治疗效果。The present invention provides a pharmaceutical composition for treating chronic pharyngitis and a preparation method and application thereof. The pharmaceutical composition is prepared from the following raw materials by weight: 10-20 parts of Luo Han Guo, 10-20 parts of black plum, 8-15 parts of platycodon grandiflorum, 5-12 parts of licorice, 5-12 parts of dandelion, 5-10 parts of sea, 5-10 parts of chrysanthemum, 5-10 parts of gardenia, 2-7 parts of amla japonica, and 2-7 parts of green fruit. The pharmaceutical composition of the invention is all composed of medicines of the same origin as medicine and food, which improves the safety of the medicine and increases the scope of application and the population. The pharmaceutical composition of the present invention can effectively treat chronic pharyngitis, and can treat pharyngeal discomfort caused by chronic pharyngitis, such as foreign body sensation, itching, burning, dryness and/or irritation, as well as slight sore throat, pharyngeal cough, Accompanied by nausea, thickening of pharyngeal mucosa, and viscous or viscous secretions and other symptoms, it can obviously eliminate or relieve symptoms. At the same time, the pharmaceutical composition of the present invention has good compatibility in flavors and is indispensable, and changing the drug ratio will affect the therapeutic effect.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicines, and particularly relates to a pharmaceutical composition for treating chronic pharyngitis, and a preparation method and application thereof.
Background
The chronic pharyngitis is diffuse pharyngeal lesion caused by chronic infection, and is characterized by mainly chronic congestion of a pharyngeal mucosa layer, more lymphocyte infiltration around blood vessels, hyperplasia of connective tissues and lymphatic tissues under the mucosa, granular swelling of the pharyngeal posterior wall, hypertrophy of mucous glands and hypersecretion of serious patients. The main symptoms are pharyngeal discomfort, such as foreign body sensation, dry throat, pharynx itch, sore throat, cough, nausea and even vomiting. The etiology includes: the local factors are: acute pharyngitis attacks repeatedly and can be converted into chronic pharyngitis. Diseases of adjacent organs, such as chronic tonsillitis, odontitis, dental caries, chronic rhinitis, chronic sinusitis and other inflammatory secretion flow into pharynx, or chronic rhinopathy causes difficulty in nasal ventilation and mouth breathing, and chronic irritation of pharynx such as excessive smoking and drinking, dust, harmful gas and spicy food can cause the disease; whole body factors: such as anemia, dyspepsia, chronic inflammation of lower respiratory tract, cardiovascular diseases, endocrine function disorder, vitamin deficiency and hypoimmunity.
The chronic pharyngitis has a certain treatment effect when being taken with antibiotics, but the disease is easy to relapse, the disease course is long, and if the chronic pharyngitis is taken with antibiotics for a long time, various complications such as bacterial resistance, imbalance of normal flora in vivo and the like can be caused. The development of the traditional Chinese medicine preparation for treating the chronic pharyngitis is a reasonable choice. The traditional Chinese medicine considers that the pathogenesis of chronic pharyngitis is mainly caused by lung-kidney yin deficiency, body fluid deficiency, flaring-up of deficient fire and throat fumigation, and the treatment mainly aims at nourishing yin and lowering fire, but the clinical symptoms show that the curative effect of a plurality of patients is poor. At present, the pharmaceutical composition for treating chronic pharyngitis is not available.
Disclosure of Invention
The invention aims to provide a pharmaceutical composition for treating chronic pharyngitis and a preparation method and application thereof.
The invention provides a pharmaceutical composition for treating chronic pharyngitis, which is a preparation prepared from the following raw material medicines in parts by weight: 10-20 parts of momordica grosvenori, 10-20 parts of dark plum, 8-15 parts of platycodon grandiflorum, 5-12 parts of liquorice, 5-12 parts of dandelion, 5-10 parts of scaphium scaphigerum, 5-10 parts of chrysanthemum, 5-10 parts of gardenia, 2-7 parts of phyllanthus emblica and 2-7 parts of Chinese olive.
Further, the pharmaceutical composition is a preparation prepared from the following raw material medicines in parts by weight: 15 parts of momordica grosvenori, 15 parts of dark plum, 12 parts of platycodon grandiflorum, 10 parts of liquorice, 10 parts of dandelion, 8 parts of scaphium scaphigerum, 8 parts of chrysanthemum, 8 parts of gardenia, 6 parts of emblic leafflower fruit and 6 parts of Chinese olive.
Furthermore, the pharmaceutical composition is a preparation prepared by taking the medicinal powder of the raw material medicines, the water or organic solvent extract of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials according to the weight ratio.
Further, the formulation is an oral formulation.
Further, the oral preparation is decoction, oral liquid, granules, capsules, tablets, powder and bagged steeping agents.
The invention also provides a preparation method of the pharmaceutical composition, which comprises the following steps:
(1) weighing the raw material medicines in the weight ratio;
(2) the raw materials are directly pulverized, or the raw materials are decocted with water or extracted by an organic solvent, the extract is concentrated, and pharmaceutically acceptable auxiliary materials are added to prepare the preparation.
Further, the preparation method comprises the following steps:
(1) weighing the raw material medicines in the weight ratio;
(2) drying the raw materials at 60-100 deg.C, pulverizing, sieving with 10-60 mesh sieve, mixing the medicinal powders, and packaging to obtain bagged steeping preparation.
The invention also provides application of the pharmaceutical composition in preparing a medicine for treating chronic pharyngitis.
Further, the chronic pharyngitis is chronic simple pharyngitis and/or chronic hypertrophic pharyngitis.
The medicinal composition consists of ten medicaments of momordica grosvenori, dark plum fruit, platycodon grandiflorum, liquorice, dandelion, boat-fruited sterculia seed, chrysanthemum, gardenia, emblic leafflower fruit and Chinese olive. The prescription takes emblic leafflower fruit and Chinese olive as monarch drugs for clearing throat and relieving sore throat. The assistant drugs are prepared from dark plum, momordica grosvenori, boat-fruited sterculia seed and platycodon grandiflorum acid which are used for sweetening yin, moistening throat and reducing phlegm, and the assistant drugs are used for rapidly improving discomfort such as dry and itching throat, expectoration and the like. The dandelion, the chrysanthemum and the gardenia are used as adjuvants for clearing away heat and toxic materials, removing dampness, eliminating damp-heat toxin and eliminating inflammation, so that the effects of monarch and minister medicines are more obvious, and the repeated attack of pharyngitis can be prevented. The guiding drug is liquorice, and has the effects of harmonizing the effect of the other drugs and detoxifying and relieving sore throat.
The pharmaceutical composition of the invention is completely composed of medicines with homology of medicine and food, improves the safety of the medicines, and increases the application range and crowds. Clinical test results show that the pharmaceutical composition can effectively treat chronic pharyngitis, and has obvious effects of eliminating or relieving symptoms of pharyngeal discomfort caused by the chronic pharyngitis, such as foreign body sensation, itching sensation, burning sensation, dryness and/or irritation, pharyngeal slight pain, pharyngeal cough, nausea, pharyngeal mucosa thickening, viscous or thick secretion and the like. Meanwhile, the medicine composition of the invention has precise and appropriate compatibility of medicines and can not achieve the effect of treatment by changing the medicine proportion.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
The raw materials and equipment used in the embodiment of the present invention are known products and obtained by purchasing commercially available products.
Example 1 preparation of a pharmaceutical composition of the invention
1. The formula of the raw material medicine is as follows: 15g of momordica grosvenori, 15g of dark plum, 12g of platycodon grandiflorum, 10g of liquorice, 10g of dandelion, 8g of scaphium scaphigerum, 8g of chrysanthemum, 8g of gardenia, 6g of emblic leafflower fruit and 6g of Chinese olive.
2. The preparation method comprises the following steps: drying the raw materials at 60-100 deg.C, pulverizing, sieving with 10-60 mesh sieve, mixing the medicinal powders, and packaging into non-woven bag to obtain bagged steeping preparation. Each bag of the soaking agent contains 2g of the raw material medicine.
Example 2 preparation of a pharmaceutical composition of the invention
1. The formula of the raw material medicine is as follows: 10g of momordica grosvenori, 10g of dark plum, 8g of platycodon grandiflorum, 5g of liquorice, 5g of dandelion, 5g of scaphium scaphigerum, 5g of chrysanthemum, 5g of gardenia, 2g of emblic leafflower fruit and 2g of Chinese olive.
2. The preparation method comprises the following steps: the preparation method is the same as that of example 1.
Example 3 preparation of a pharmaceutical composition of the invention
1. The formula of the raw material medicine is as follows: 20g of momordica grosvenori, 20g of dark plum, 15g of platycodon grandiflorum, 12g of liquorice, 12g of dandelion, 10g of scaphium scaphigerum, 10g of chrysanthemum, 10g of gardenia, 7g of emblic leafflower fruit and 7g of Chinese olive.
2. The preparation method comprises the following steps: the preparation method is the same as that of example 1.
The beneficial effects of the present invention are demonstrated by specific clinical trials below.
Test example 1 clinical effects of the pharmaceutical composition of the present invention
1. Clinical data
794 patients with chronic pharyngitis are 25-55 years old.
1.1 inclusion criteria
The diagnosis is that the patient has chronic simple pharyngitis or chronic hypertrophic pharyngitis. The symptoms include pharyngeal discomfort (foreign body sensation, itching sensation, burning sensation, dryness and/or irritation), and some patients are accompanied by pharyngeal pain, pharyngeal cough, nausea, pharyngeal mucosa thickening, viscous or purulent secretion, etc.
② the age of 25-55 years old.
1.2 exclusion criteria
Those not meeting the inclusion standard;
patients and family members refuse to cooperate with the treatment;
③ allergic constitution, or known to be allergic to the ingredients;
and fourthly, the patients are participating in other medicine clinical tests.
2. Method of treatment
Test groups: a bag prepared according to example 1 of the present invention was administered to a patient. The taking method comprises the following steps: one bag of the tea is soaked in boiling water every day, and the tea is drunk after breakfast and before sleep; one treatment course is 5 days, and 2 treatment courses are total.
Control group: the raw material medicine formula comprises 20g of figwort, 15g of myrobalan, 15g of momordica grosvenori, 15g of dark plum, 12g of platycodon grandiflorum, 10g of liquorice, 8g of boat-fruited sterculia seed, 8g of chrysanthemum, 6g of emblic leafflower fruit and 6g of prunus mume; the preparation method is the same as that of the embodiment 1, the bulk drugs with the formula amount are dried at the temperature of 60-100 ℃ and then crushed, sieved by a sieve with 10-60 meshes, and the medicinal powder is uniformly mixed and put into a non-woven fabric bag to obtain the bagged steeping agent. Each bag of the soaking agent contains 2g of the raw material medicine. The taking method comprises the following steps: the administration method was the same as that of the test group.
3. Determination of therapeutic effect and therapeutic effect
The determination of the curative effect and the curative effect of the bagged steeping drug for treating the chronic pharyngitis are shown in tables 1 to 4.
Table 1 shows the therapeutic effect and therapeutic effect of each group of bagged steeping drug for treating chronic simple pharyngitis with pharyngeal discomfort (foreign body sensation, itching sensation, burning sensation, dryness sensation and/or irritation).
TABLE 1 therapeutic effect judgment and therapeutic effect of chronic pharyngitis
Table 2 shows the therapeutic effect and judgment of the treatment effect of each group of the bagged steeping drug for chronic simple pharyngitis with symptoms of sore throat.
TABLE 2 therapeutic effect determination and therapeutic effect of chronic pharyngitis
Table 3 shows the therapeutic effect and the therapeutic effect of each group of bagged steeping drug for treating chronic simple pharyngitis with symptoms of pharyngeal cough and nausea.
TABLE 3 therapeutic effect judgment and therapeutic effect of chronic pharyngitis
Table 4 shows the therapeutic effect and judgment of the treatment effect of each group of bagged steeping drug for treating chronic simple pharyngitis with symptoms of pharyngeal mucosa thickening, sticky or purulent secretion.
TABLE 4 therapeutic effect judgment and therapeutic effect of chronic pharyngitis
The clinical test results of the pharmaceutical composition of the invention show that: under the condition of the same dosage and administration method, the pharmaceutical composition of the invention has obviously better elimination or alleviation of symptoms of pharyngeal discomfort (including foreign body sensation, itching sensation, burning sensation, dryness sensation and/or irritation sensation), pharyngeal slight pain, pharyngeal cough, nausea, pharyngeal mucosa thickening, viscous or purulent secretion and the like caused by chronic pharyngitis than a control group. The pharmaceutical composition can be used for effectively treating chronic pharyngitis.
Test example 2 comparison of Effect of different formulations of the pharmaceutical composition of the present invention
1. Therapeutic effect on chronic pharyngitis and sore throat
Formula 1: the bagged steeping agent prepared in example 1 of the present invention;
and (2) formula: the bagged steeping preparation prepared in example 2 of the present invention.
60 chronic pharyngitis patients (60 chronic pharyngitis patients all had symptoms of sore throat) were selected according to inclusion criteria and exclusion criteria in test example 1 and were randomly divided into 2 groups. Each group was treated according to the treatment method of test example 1, and each of formulas 1 and 2 was administered. The treatment results are shown in table 5.
TABLE 5 curative effect of bagged steeping drug for chronic pharyngitis and sore throat
2. Can be used for treating pharyngeal discomfort (including foreign body sensation, itching sensation, burning sensation, dryness or irritation) of chronic pharyngitis
Formula 1: the bagged steeping agent prepared in example 1 of the present invention;
and (2) formula: the bagged steeping preparation prepared in example 3 of the present invention.
60 chronic pharyngitis patients (all 60 chronic pharyngitis patients had symptoms of pharyngeal discomfort including foreign body sensation, itching sensation, burning sensation, dryness sensation and/or irritation) were selected according to inclusion criteria and exclusion criteria in test example 1 and were randomly divided into 2 groups. Each group was treated according to the treatment method of test example 1, and each of formulas 1 and 2 was administered. The treatment results are shown in table 6.
TABLE 6 therapeutic effect of various groups of bagged steeping drug on pharyngeal discomfort (foreign body sensation, itching sensation, burning sensation, dryness and/or irritation) symptoms of chronic pharyngitis
From the above test results, it is understood that the prescription dosages of the bagged steeping drug prepared in example 2 and example 3 are the same as those of example 1, but the curative effect of the bagged steeping drug for chronic pharyngitis symptoms prepared in example 1 is significantly better than that of example 2 and example 3 under different drug administration ratios.
In conclusion, the pharmaceutical composition is completely composed of medicines with homology of medicine and food, so that the safety of the medicines is improved, and the application range and the population are increased. Clinical test results show that the pharmaceutical composition can effectively treat chronic pharyngitis, and has obvious effects of eliminating or relieving symptoms of pharyngeal discomfort caused by the chronic pharyngitis, such as foreign body sensation, itching sensation, burning sensation, dryness and/or irritation, pharyngeal slight pain, pharyngeal cough, nausea, pharyngeal mucosa thickening, viscous or thick secretion and the like. Meanwhile, the medicine composition of the invention has precise and appropriate compatibility of medicines and can not achieve the effect of treatment by changing the medicine proportion.
Claims (8)
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| CN113230350A (en) * | 2021-06-09 | 2021-08-10 | 岳康医疗生物科技有限公司 | Formula and preparation method of herbaceous plant buccal tablet with effects of clearing and moistening throat |
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