CN110302228A - A kind of biological agent that treating hemorrhoid and its application - Google Patents
A kind of biological agent that treating hemorrhoid and its application Download PDFInfo
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Abstract
The present invention relates to a kind of biological agent for treating hemorrhoid and its applications, belong to medical pharmacy field.The biological agent of this treatment hemorrhoid, it is composed of the following components by weight: 50-60 parts of hazel extracts, 3-8 parts of glycerol, 1-3 parts of propylene glycol, 5-6 parts of chamomile hydrosols, 0.1-0.3 parts of methyl p-hydroxybenzoates, 0.02-0.05 parts of propylparaben, 0.2-0.6 parts of bi-imidazolidinyl ureas, 0.4-1 parts of citric acids, 0.5-1.5 parts of sodium citrates, 0.1-0.3 parts of Phenoxyethanols, 0.3-0.8 parts of Folium Pini extracts and 35-50 parts of water.The beneficial effect of this biological agent is that have apparent therapeutic effect to hemorrhoid, while biological agent can conveniently be prepared into various treatment drugs, and patient is facilitated to use.
Description
Technical field
The invention belongs to medical pharmacy fields, and in particular to a kind of biological agent for treating hemorrhoid and its application.
Background technique
Hemorrhoid are a kind of clinically most common disease of anus, are veins under the mucous membrane of human rectum end and under anal canal skin
The raw expansion of burst and buckling are formed by flexible venous mass.It is more common in frequent standing person and long seated user.Hemorrhoid include internal piles, external piles
And mixed hemorrhoid, it is that varicose occurs for the veniplex of anorectal bottom and anal mucosa and the soft veins of the one or more that is formed
A kind of chronic disease of group.Internal piles is that the hemorrhoid of long anal canal section start again almost exist if the vein of expansion is located at further below
On anal canal mouth, the vein of this varicose is just external piles.Show that hemorrhoid account in all anorectal diseases at present according to related data
87.25%, it is the very high anorectal disease of disease incidence.
Tradition to the treatment majority of hemorrhoid is treated using operation at present, and surgical result is significant, but is performed the operation
It is easily recurred after treatment, so that patient is still perplexed by hemorrhoid.Also there is part for oral administration at present simultaneously or the drug of external application, still
It is bad to the therapeutic effect of hemorrhoid.
Summary of the invention
In order to solve the above-mentioned technical problem the present invention provides a kind of biological agent for treating hemorrhoid and its application, this biological medicament
Agent has apparent therapeutic effect to hemorrhoid, while biological agent can conveniently be prepared into various treatment drugs for facilitating patient
It uses.
The technical scheme to solve the above technical problems is that a kind of biological agent for treating hemorrhoid, by weight
It counts composed of the following components: 50-60 parts of hazel extracts, 3-8 parts of glycerol, 1-3 parts of propylene glycol, 5-6 parts of chamomile hydrosols,
0.1-0.3 parts of methyl p-hydroxybenzoates, 0.02-0.05 parts of propylparaben, 0.2-0.6 parts of double imidazolidinyls
Urea, 0.4-1 parts of citric acids, 0.5-1.5 parts of sodium citrates, 0.1-0.3 parts of Phenoxyethanols, 0.3-0.8 parts of Folium Pini extracts and 35-
50 parts of water.
Effectively disappear the beneficial effects of the present invention are: this biological agent can be formed the affected part of patient by rational proportion
Swollen, anti-inflammatory and sterilization, effectively treat hemorrhoid, mitigate the pain that patient is subject to, in addition this biological agent is easily prepared
At the various suitable medicaments used, facilitates different patients to use, can be improved by this biological agent to the effective of hemorrhoid treating
Property, most of crowds are applicable in.
Based on the above technical solution, the present invention can also be improved as follows.
Further, composed of the following components by weight: 50-55 parts of hazel extracts, 4-6 parts of glycerol, 1-2 part third
Glycol, 5-6 parts of chamomile hydrosols, 0.1-0.2 parts of methyl p-hydroxybenzoates, 0.02-0.04 parts of propylparaben,
0.2-0.5 parts of bi-imidazolidinyl ureas, 0.5-0.8 parts of citric acids, 0.5-1 parts of sodium citrates, 0.2-0.3 parts of Phenoxyethanols, 0.4-
0.7 part of Folium Pini extract and 40-45 parts of water.
Beneficial effect using above-mentioned further scheme is: the effect for treating hemorrhoid is more preferable.
Further, composed of the following components by weight: 52 parts of hazel extracts, 5 parts of glycerol, 1 part of propylene glycol, 5
Part chamomile hydrosol, 0.2 part of methyl p-hydroxybenzoate, 0.03 part of propylparaben, 0.3 part of double imidazolidinyl
Urea, 0.6 part of citric acid, 0.75 part of sodium citrate, 0.2 part of Phenoxyethanol, 0.6 part of Folium Pini extract and 45 parts of water.
Beneficial effect using above-mentioned further scheme is: the effect for treating hemorrhoid is more preferable.
The present invention also provides a kind of applications using above-mentioned biological agent in the drug in preparation treatment hemorrhoid field.
The beneficial effect that the present invention applies is: the effective percentage that this biological agent treats hemorrhoid is very high, be suitable for it is big absolutely
Number crowds carry out using can effectively mitigate pain of the patient by disease.
The present invention also provides a kind of preparation methods of wet tissue for treating hemorrhoid, comprising:
1) raw material of above-mentioned biological agent is weighed, stirs 20-30min after mixing, obtains liquid bio preparation；
2) non-woven fabrics is taken, non-woven fabrics is uniformly cut into circular block shape, and be fitted into box；
3) liquid tank is attached in box by filling production lines, non-woven fabrics is drenched, wet tissue is made.
The beneficial effect that the present invention treats the wet tissue preparation method of hemorrhoid is: preparation process is simple, when being prepared into wet tissue, side
Just patient wipes affected part, and preparation wet tissue process is simple and convenient.
The present invention also provides a kind of preparation methods for treating hemorrhoid poultice, comprising:
S1,30-40 parts by weight beeswax is taken, is heated under 40-50 DEG C of water-bath, weigh the raw material of above-mentioned biological agent, successively
It is added in beeswax, keeps stirring 40-50min under heated condition, obtain thick substances；
S2, thick substances are ground 2-3 times, and squeezes out and filters through 40 mesh filter screens, be governed hemorrhoid after natural cooling
Poultice；
S3, treatment hemorrhoid poultice is dispensed into pencil and obtains finished product.
The beneficial effect that the present invention treats the preparation method of hemorrhoid poultice is: preparation process is simple, is prepared into poultice
When, patient, which can facilitate, is applied to affected part for ointment, and easy to use, the poultice prepared additionally by this preparation method is more square
Just.
The spraying preparation method of hemorrhoid is treated the present invention also provides a kind of, comprising:
A1, the raw material for weighing above-mentioned biological agent stir 40-50min after sequentially adding mixing, obtain liquid bio system
Agent；
A2, consummate liquid is obtained through 0.22 μm of filtering with microporous membrane to liquid bio preparation, using high pressure by consummate liquid
It is circulated into spray tank and obtains finished product.
The beneficial effect that the present invention treats the spraying preparation method of hemorrhoid is: preparation process is simple, when being prepared into spraying, suffers from
Person, which can facilitate, sprays medicament to affected part, and summer is suitble to use, easy to use.
Specific embodiment
The principles and features of the present invention are described below, and the given examples are served only to explain the present invention, is not intended to limit
Determine the scope of the present invention.
Embodiment 1
It is composed of the following components by weight the present embodiment provides a kind of biological agent for treating hemorrhoid: 50 parts of gold threads
Plum extracting solution, 4 parts of glycerol, 2 parts of propylene glycol, 5 parts of chamomile hydrosols, 0.1 part of methyl p-hydroxybenzoate, 0.02 part to hydroxyl
Propyl benzoate, 0.3 part of bi-imidazolidinyl urea, 0.5 part of citric acid, 1 part of sodium citrate, 0.2 part of Phenoxyethanol, 0.3 part of pine needle
Extract, 40 parts of water.
The present embodiment also provides a kind of wet tissue preparation method for treating hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 25min after sequentially adding mixing, obtains liquid bio preparation；
Non-woven fabrics is taken, non-woven fabrics is uniformly cut into circular block shape, and be fitted into box；
Liquid tank is attached in box by filling production lines, non-woven fabrics is drenched, wet tissue is made.
The present embodiment also provides a kind of preparation method for treating hemorrhoid poultice, comprising:
35 parts by weight beeswaxs are taken, are heated under 50 DEG C of water-baths, the raw material of above-mentioned biological agent is weighed, is added sequentially to beeswax
In, it keeps stirring 45min under heated condition, obtains thick substances；
Thick substances are ground 3 times, and squeezes out and filters through 40 mesh filter screens, are governed hemorrhoid paste after natural cooling
Medicine；
Treatment hemorrhoid poultice is dispensed into pencil and obtains finished product.
The present embodiment, which also provides, a kind of treats the spraying preparation method of hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 50min after sequentially adding mixing, obtains liquid bio preparation；
Consummate liquid is obtained through 0.22 μm of filtering with microporous membrane to liquid bio preparation, is poured into consummate liquid using high pressure
Finished product is obtained into spray tank.
Embodiment 2
It is composed of the following components by weight the present embodiment provides a kind of biological agent for treating hemorrhoid: 55 parts of gold threads
Plum extracting solution, 6 parts of glycerol, 3 parts of propylene glycol, 5 parts of chamomile hydrosols, 0.3 part of methyl p-hydroxybenzoate, 0.05 part to hydroxyl
Propyl benzoate, 0.4 part of bi-imidazolidinyl urea, 0.6 part of citric acid, 0.75 part of sodium citrate, 0.3 part of Phenoxyethanol, 0.4 portion of pine
Leaf extract, 35 parts of water.
The present embodiment also provides a kind of wet tissue preparation method for treating hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 25min after sequentially adding mixing, obtains liquid bio preparation；
Non-woven fabrics is taken, non-woven fabrics is uniformly cut into circular block shape, and be fitted into box；
Liquid tank is attached in box by filling production lines, non-woven fabrics is drenched, wet tissue is made.
The present embodiment also provides a kind of preparation method for treating hemorrhoid poultice, comprising:
40 parts by weight beeswaxs are taken, are heated under 50 DEG C of water-baths, the raw material of above-mentioned biological agent is weighed, is added sequentially to beeswax
In, it keeps stirring 45min under heated condition, obtains thick substances；
Thick substances are ground 2 times, and squeezes out and filters through 40 mesh filter screens, are governed hemorrhoid paste after natural cooling
Medicine；
Treatment hemorrhoid poultice is dispensed into pencil and obtains finished product.
The present embodiment, which also provides, a kind of treats the spraying preparation method of hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 45min after sequentially adding mixing, obtains liquid bio preparation；
Consummate liquid is obtained through 0.22 μm of filtering with microporous membrane to liquid bio preparation, is poured into consummate liquid using high pressure
Finished product is obtained into spray tank.
Embodiment 3
It is composed of the following components by weight the present embodiment provides a kind of biological agent for treating hemorrhoid: 60 parts of gold threads
Plum extracting solution, 5 parts of glycerol, 3 parts of propylene glycol, 6 parts of chamomile hydrosols, 0.3 part of methyl p-hydroxybenzoate, 0.03 part to hydroxyl
Propyl benzoate, 0.4 part of bi-imidazolidinyl urea, 0.4 part of citric acid, 1.5 parts of sodium citrates, 0.3 part of Phenoxyethanol, 0.5 portion of pine
Leaf extract, 50 parts of water.
The present embodiment also provides a kind of wet tissue preparation method for treating hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 30min after sequentially adding mixing, obtains liquid bio preparation；
Non-woven fabrics is taken, non-woven fabrics is uniformly cut into circular block shape, and be fitted into box；
Liquid tank is attached in box by filling production lines, non-woven fabrics is drenched, wet tissue is made.
The present embodiment also provides a kind of preparation method for treating hemorrhoid poultice, comprising:
40 parts by weight beeswaxs are taken, are heated under 50 DEG C of water-baths, the raw material of above-mentioned biological agent is weighed, is added sequentially to beeswax
In, it keeps stirring 50min under heated condition, obtains thick substances；
Thick substances are ground 3 times, and squeezes out and filters through 40 mesh filter screens, are governed hemorrhoid paste after natural cooling
Medicine；
Treatment hemorrhoid poultice is dispensed into pencil and obtains finished product.
The present embodiment, which also provides, a kind of treats the spraying preparation method of hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 50min after sequentially adding mixing, obtains liquid bio preparation；
Consummate liquid is obtained through 0.22 μm of filtering with microporous membrane to liquid bio preparation, is poured into consummate liquid using high pressure
Finished product is obtained into spray tank.
Embodiment 4
It is composed of the following components by weight the present embodiment provides a kind of biological agent for treating hemorrhoid: 52 parts of gold threads
Plum extracting solution, 5 parts of glycerol, 1 part of propylene glycol, 6 parts of chamomile hydrosols, 0.2 part of methyl p-hydroxybenzoate, 0.03 part to hydroxyl
Propyl benzoate, 0.3 part of bi-imidazolidinyl urea, 0.6 part of citric acid, 0.75 part of sodium citrate, 0.2 part of Phenoxyethanol, 0.6 portion of pine
Leaf extract, 45 parts of water.
The present embodiment also provides a kind of wet tissue preparation method for treating hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 30min after sequentially adding mixing, obtains liquid bio preparation；
Non-woven fabrics is taken, non-woven fabrics is uniformly cut into circular block shape, and be fitted into box；
Liquid tank is attached in box by filling production lines, non-woven fabrics is drenched, wet tissue is made.
The present embodiment also provides a kind of preparation method for treating hemorrhoid poultice, comprising:
35 parts by weight beeswaxs are taken, are heated under 45 DEG C of water-baths, the raw material of above-mentioned biological agent is weighed, is added sequentially to beeswax
In, it keeps stirring 45min under heated condition, obtains thick substances；
Thick substances are ground 2 times, and squeezes out and filters through 40 mesh filter screens, are governed hemorrhoid paste after natural cooling
Medicine；
Treatment hemorrhoid poultice is dispensed into pencil and obtains finished product.
The present embodiment, which also provides, a kind of treats the spraying preparation method of hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 50min after sequentially adding mixing, obtains liquid bio preparation；
Consummate liquid is obtained through 0.22 μm of filtering with microporous membrane to liquid bio preparation, is poured into consummate liquid using high pressure
Finished product is obtained into spray tank.
Embodiment 5
It is composed of the following components by weight the present embodiment provides a kind of biological agent for treating hemorrhoid: 50 parts of gold threads
Plum extracting solution, 8 parts of glycerol, 3 parts of propylene glycol, 5 parts of chamomile hydrosols, 0.3 part of methyl p-hydroxybenzoate, 0.03 part to hydroxyl
Propyl benzoate, 0.05 part of bi-imidazolidinyl urea, 0.6 part of citric acid, 0.8 part of sodium citrate, 0.3 part of Phenoxyethanol, 0.8 portion of pine
Leaf extract, 50 parts of water.
The present embodiment also provides a kind of wet tissue preparation method for treating hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 25min after sequentially adding mixing, obtains liquid bio preparation；
Non-woven fabrics is taken, non-woven fabrics is uniformly cut into circular block shape, and be fitted into box；
Liquid tank is attached in box by filling production lines, non-woven fabrics is drenched, wet tissue is made.
The present embodiment also provides a kind of preparation method for treating hemorrhoid poultice, comprising:
40 parts by weight beeswaxs are taken, are heated under 50 DEG C of water-baths, the raw material of above-mentioned biological agent is weighed, is added sequentially to beeswax
In, it keeps stirring 50min under heated condition, obtains thick substances；
Thick substances are ground 3 times, and squeezes out and filters through 40 mesh filter screens, are governed hemorrhoid paste after natural cooling
Medicine；
Treatment hemorrhoid poultice is dispensed into pencil and obtains finished product.
The present embodiment, which also provides, a kind of treats the spraying preparation method of hemorrhoid, comprising:
The raw material for weighing above-mentioned biological agent stirs 40min after sequentially adding mixing, obtains liquid bio preparation；
Consummate liquid is obtained through 0.22 μm of filtering with microporous membrane to liquid bio preparation, is poured into consummate liquid using high pressure
Finished product is obtained into spray tank.
Above-described embodiment 1-5 is carried out clinical effectiveness experiment by the present invention, and is bought existing mayinglong shexiang zhichuang ointments and used
It is compared in as control.
General data: comparing clinical test for above-described embodiment 1-5 and comparative example, choose 700 patients, wherein
350 people of male, 350 people of women, age are 18-40 years old, are uniformly distributed, wherein 700 patients averagely suffer from hemorrhoid 1 year, longest
Person is no more than 2 years, is divided into 6 groups, and 1-5 group is 120 people, and the 6th group is 100 people, so that embodiment 1-5 is respectively to 1-5 group
120 people treat, wherein the wet tissue for the treatment of hemorrhoid, spraying and poultice treat 40 people of each group, comparative example treatment respectively
100 people.
Diagnostic criteria:
Specifically used method: being once in the morning and once at night uniformly used for affected part, and observation uses patient's situation after 30 days.
Criterion of therapeutical effect:
1, fully recover: hemorrhoid obviously subside, and patient's hemorrhoid part is without bleeding and pruritis；
2, improve: hemorrhoid partial remission, patient's pruritis are substantially reduced
3, invalid: hemorrhoid are unchanged.
Treatment results, table specific as follows:
| Project | In vain | It improves | Recovery from illness | It is efficient |
| Embodiment 1 | 5 | 97 | 18 | 95.8% |
| Embodiment 2 | 8 | 101 | 11 | 93.3% |
| Embodiment 3 | 4 | 93 | 23 | 96.6% |
| Embodiment 4 | 6 | 94 | 20 | 95% |
| Embodiment 5 | 5 | 103 | 12 | 95.8% |
| Comparative example | 30 | 65 | 5 | 70% |
It is seen from the above data that the biological agent for the treatment of hemorrhoid of the invention prepare wet tissue, spraying and poultice
93-96% is reached for the effective percentage of hemorrhoid, therapeutic effect is significantly better than ointment on sale at present, to the effective percentage of hemorrhoid treating
It is very high.
The foregoing is merely presently preferred embodiments of the present invention, is not intended to limit the invention, it is all in spirit of the invention and
Within principle, any modification, equivalent replacement, improvement and so on be should all be included in the protection scope of the present invention.
Claims (7)
1. a kind of biological agent for treating hemorrhoid, which is characterized in that composed of the following components by weight: 50-60 parts of gold threads
Plum extracting solution, 3-8 parts of glycerol, 1-3 parts of propylene glycol, 5-6 parts of chamomile hydrosols, 0.1-0.3 parts of methyl p-hydroxybenzoates,
0.02-0.05 parts of propylparaben, 0.2-0.6 parts of bi-imidazolidinyl ureas, 0.4-1 parts of citric acids, 0.5-1.5 parts of lemons
Lemon acid sodium, 0.1-0.3 parts of Phenoxyethanols, 0.3-0.8 parts of Folium Pini extracts and 35-50 parts of water.
2. treating the biological agent of hemorrhoid according to claim 1, which is characterized in that by weight by following components group
At: 50-55 parts of hazel extracts, 4-6 parts of glycerol, 1-2 parts of propylene glycol, 5-6 parts of chamomile hydrosols, 0.1-0.2 parts to hydroxyl
Methyl benzoate, 0.02-0.04 parts of propylparaben, 0.2-0.5 parts of bi-imidazolidinyl ureas, 0.5-0.8 portions of lemons
Acid, 0.5-1 parts of sodium citrates, 0.2-0.3 parts of Phenoxyethanols, 0.4-0.7 parts of Folium Pini extracts and 40-45 parts of water.
3. treating the biological agent of hemorrhoid according to claim 2, which is characterized in that by weight by following components group
At: 52 parts of hazel extracts, 5 parts of glycerol, 1 part of propylene glycol, 5 parts of chamomile hydrosols, 0.2 part of methyl p-hydroxybenzoate,
0.03 part of propylparaben, 0.3 part of bi-imidazolidinyl urea, 0.6 part of citric acid, 0.75 part of sodium citrate, 0.2 part of benzene
Oxyethanol, 0.6 part of Folium Pini extract and 45 parts of water.
4. a kind of application of biological agent as described in any one of claims 1-3 in the drug in preparation treatment hemorrhoid field.
5. a kind of preparation method for the wet tissue for treating hemorrhoid characterized by comprising
1) raw material of any one of claim 1-3 biological agent is weighed, 20-30min is stirred after mixing, obtains liquid bio
Preparation；
2) non-woven fabrics is taken, non-woven fabrics is uniformly cut into circular block shape, and be fitted into box；
3) liquid tank is attached in box by filling production lines, non-woven fabrics is drenched, wet tissue is made.
6. a kind of preparation method for treating hemorrhoid poultice characterized by comprising
S1,30-40 parts by weight beeswax is taken, is heated under 40-50 DEG C of water-bath, weigh any one of claim 1-3 biology system
The raw material of agent, is added sequentially in beeswax, keeps stirring 40-50min under heated condition, obtains thick substances；
S2, thick substances are ground 2-3 times, and squeezes out and filters through 40 mesh filter screens, be governed hemorrhoid paste after natural cooling
Medicine；
S3, treatment hemorrhoid poultice is dispensed into pencil and obtains finished product.
7. a kind of treat the spraying preparation method of hemorrhoid characterized by comprising
The raw material of a1, the biological agent that any one of weighs claim 1-3, stir 40-50min after sequentially adding mixing, obtain
To liquid bio preparation；
A2, consummate liquid is obtained through 0.22 μm of filtering with microporous membrane to liquid bio preparation, is poured into consummate liquid using high pressure
Finished product is obtained into spray tank.
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| CN201910634558.8A CN110302228A (en) | 2019-07-15 | 2019-07-15 | A kind of biological agent that treating hemorrhoid and its application |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114788801A (en) * | 2022-04-28 | 2022-07-26 | 复旦大学附属中山医院 | Pain-relieving and itching-relieving composition, pain-relieving and itching-relieving solution and preparation method and application thereof |
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2019
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114788801A (en) * | 2022-04-28 | 2022-07-26 | 复旦大学附属中山医院 | Pain-relieving and itching-relieving composition, pain-relieving and itching-relieving solution and preparation method and application thereof |
| CN114788801B (en) * | 2022-04-28 | 2024-12-31 | 复旦大学附属中山医院 | Analgesic and antipruritic composition, analgesic and antipruritic solution, preparation method and use thereof |
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Application publication date: 20191008 |