CN110236971B - Antibacterial hand sanitizer containing counter ion quaternary ammonium salt and preparation method thereof - Google Patents

Abstract

The invention discloses a counter ion quaternary ammonium salt-containing antibacterial hand sanitizer and a preparation method thereof. The antibacterial hand sanitizer is prepared from the following raw materials in percentage by weight: 1.0-7.0% of an amphoteric surfactant; 1.0-8.0% of polyglucoside; 0.5-3.0% of grease ethoxylate; 0.2-2.0% of counter ion quaternary ammonium salt; 0.5-5.0% of a humectant; 0.03-0.2% of thickening agent; 0-0.01% of a pH regulator; 0-0.1% of essence; 0-0.01% of pigment; the balance being water. The counter-ion quaternary ammonium salt used in the invention has no drug resistance to microorganisms, can achieve excellent sterilization and bacteriostasis effects with a small addition amount, has good compounding performance with other components, and has high operability of the preparation method; the overall formula of the product embodies the characteristic of greenness; the obtained antibacterial hand sanitizer has good killing capacity on gram-negative bacteria, gram-positive bacteria and fungi.

Description

A kind of antibacterial hand sanitizer containing counter ion quaternary ammonium salt and preparation method thereof

technical field

The invention relates to an antibacterial hand wash containing a counterion quaternary ammonium salt and a preparation method thereof, and belongs to the field of the antibacterial hand wash and its preparation.

Background technique

The main function of hand sanitizer is to clean the skin of hands, and some specific ingredients can also play a role in antibacterial and sterilization. The main bactericidal and bacteriostatic substances of antibacterial hand sanitizers sold on the market are chlorine-containing disinfectants such as p-chloro-m-dimethylphenol or phenol-based disinfectants. For example, the antibacterial hand sanitizers of Welsh and Dettol have the main antibacterial component of p-chloro-meta-xylenol; the main antibacterial component of the blue moon aloe antibacterial hand sanitizer is o-phenylphenol; the antibacterial component of Shufujia series products Substances are often used zinc pyrithione (zinc pyrithione) and Dibaofu triclocarban. However, some of these chemical substances have been proved to be harmful or potentially harmful. Among them, the US FDA has banned the addition of triclocarban and triclosan; There is also a certain stimulation.

Chinese invention patent CN108685733A discloses a kind of antibacterial hand sanitizer, wherein the antibacterial substances are polypeptides, polysaccharides, and alkaloids extracted from traditional Chinese medicine. It has poor compounding stability with other surfactants, is sensitive to temperature and pH, and is not suitable for large-scale production. Chinese invention patents CN108567649A, CN108514533A, etc. also proposed the method of adding traditional Chinese medicine extracts as antibacterial substances to hand sanitizers.

Quaternary ammonium salts have been used for many years as a broad-spectrum bactericide. The commonly used models are 1227, 1231, D1021, etc., which have the advantages of fast sterilization onset, long duration of action, and low price. When in contact with bacteria, they can act quickly. In the cell structure, the bacteria dissolve and die. However, conventional quaternary ammonium salts have been used for many years, and most microorganisms have developed resistance to them, followed by a continuous increase in the amount of use and a decrease in mildness, and the poor biodegradability of conventional quaternary ammonium salts will Pollution of the environment, especially water bodies.

SUMMARY OF THE INVENTION

The purpose of the present invention is to provide a kind of antibacterial hand sanitizer containing counter-ion quaternary ammonium salt and preparation method thereof, the hand sanitizer has long-acting antibacterial properties, excellent biodegradation performance, and does not need to add preservatives.

The invention provides a kind of antibacterial hand sanitizer containing counter-ion quaternary ammonium salt, which is composed of the following raw materials by weight percentage:

Amphoteric surfactant 1.0~7.0%;

Polyglucoside 1.0~8.0%;

Oil ethoxylate 0.5~3.0%;

Counter ion quaternary ammonium salt 0.2~2.0%;

Humectant 0.5~5.0%;

Thickener 0.03~0.2%;

pH regulator 0~0.01%;

Flavor 0~0.1%;

Pigment 0~0.01%;

The remainder is water.

In the above-mentioned antibacterial hand sanitizer, its described counter-ion quaternary ammonium salt is a novel quaternary ammonium salt, and its general formula is:

In the formula: R ₁ and R ₂ are alkyl chains with 1 to 18 carbon atoms; X is NO ₃ , HCOO or CH ₃ (CH ₂ ) _n COO, and n is an integer between 0 and 6. Wherein, the counter ion quaternary ammonium salt can be any one of them, and can also be a mixture of several, and the preferred carbon atoms of R ₁ and R ₂ are 8-14. The weight percentage of the counter ion quaternary ammonium salt is 0.2 to 2.0%, preferably 0.5 to 1.5% by weight.

In the above-mentioned antibacterial hand sanitizer, the amphoteric surfactant described in it is a mixture of one or more of betaine series surfactants, including 1. alkyl betaine, and the number of alkyl carbon atoms is 8 to 18; ②Amidopropyl betaine, the number of carbon atoms in the amide group is 8~22, including unsaturated amide group with carbon-carbon double bond in the amide group; ③Sulfobetaine. Preferably, it is a betaine surfactant having 10 to 14 carbon atoms. The weight percent of betaine surfactant is 1.0~7.0%, preferably 3.0%~5.0% by weight.

In the above-mentioned antibacterial hand sanitizer, the polyglucoside described in it is a compound with the following general formula:

In the formula: n is an integer between 1 and 3; R includes any one of the following two: ① a straight or branched alkyl chain with 8 to 22 carbon atoms; ② a shape such as -(CH ₂ CH ₂ O) _m R ₁ structure of fatty alcohol polyoxyethylene ether chain, m=an integer between 1 and 9, and R ₁ is a straight or branched chain alkyl group with 8 to 22 carbon atoms. Further, R includes any one of the following two: ① a straight-chain or branched alkyl chain with 8 to 14 carbon atoms, ② a structure such as -(CH ₂ CH ₂ O) _m R ₁ Fatty alcohol polyoxyethylene ether chain, m=an integer between 1 and 9, and R ₁ is a straight-chain or branched-chain alkyl group with 8-14 carbon atoms. The weight percentage of polyglucoside is 1.0-8.0%, preferably 4.0-6.0% by weight.

In the above-mentioned antibacterial hand sanitizer, its described grease ethoxylate is palm kernel oil ethoxylate, palm oil ethoxylate, castor oil ethoxylate, soybean oil ethoxylate, cottonseed oil ethoxylate. A composition of one or more of oxygenates, rapeseed oil ethoxylates and coconut oil ethoxylates, the preferred oil and fat ethoxylates are soybean oil ethoxylates and palm oil ethoxylates , a combination of one or more of castor oil ethoxylates. The weight percent of the oil and fat ethoxylate is 0.5-3.0%, preferably 0.5-2.0% by weight.

In the above-mentioned antibacterial hand sanitizer, the moisturizing agent is one or more of glycerin (glycerol), propylene glycol, butylene glycol, xylitol and sorbitol.

In the above-mentioned antibacterial hand sanitizer, the thickener is: one or more of CMC (sodium carboxymethyl cellulose), hydroxyethyl cellulose, carbomer and 6501.

In the above-mentioned antibacterial hand sanitizer, its pH regulator is: citric acid.

In the above-mentioned antibacterial hand sanitizer, its essence is: a kind of in green tea, lavender, jasmine fragrance and rose.

The pigment is one of amaranth pigment, tender green pigment, lemon yellow pigment and yellow pigment.

The invention provides the above-mentioned preparation method of the antibacterial hand sanitizer containing counter-ion quaternary ammonium salt, comprising the following steps:

The raw materials are melted in a hot water bath; first add water with 50% of the total mass of the raw materials into the container, after the water temperature is heated to 60 ℃, add the thickener to it and stir and mix evenly; then add the amphoteric surfactant, polyglucoside in turn , Add oil ethoxylate into the container, stir until all the raw materials are dissolved, then cool down to 30~40℃; add counter-ion quaternary ammonium salt, humectant, pigment and essence, adjust the pH to 6.3~6.7 with pH adjuster , adding the remaining amount of water, and stirring to obtain the antibacterial hand sanitizer.

The above-mentioned preparation method specifically comprises the following steps:

① Melt the raw materials in a hot water bath (60~70℃) according to their weight percentage composition;

② Add water containing 50% of the total mass of the raw materials into the container, start stirring, and after the water temperature is heated to 60 °C, add the thickener to it and stir until dissolved;

③ Add the amphoteric surfactant, polyglucoside and oil ethoxylate into the container in turn, stir until all the raw materials are dissolved, and then cool down to 30~40℃;

④ Add counter-ion quaternary ammonium salt, humectant, pigment and essence, adjust the pH to 6.3~6.7 with a pH adjuster, add the remaining amount of water, and stir to obtain the antibacterial hand sanitizer.

The antibacterial hand sanitizer containing counter-ion quaternary ammonium salt of the present invention is tested for its antibacterial performance according to the light industry standard QB/T 2738-2012 "Evaluation Method for Antibacterial and Bacteriostatic Effect of Daily Chemical Products", and the selected The method was suspension quantitative method, and the selected strains were Escherichia coli, Staphylococcus aureus and Candida albicans.

Compared with the existing antibacterial hand sanitizer, the antibacterial hand sanitizer containing counter-ion quaternary ammonium salt of the present invention has the following advantages:

①The present invention uses the latest research result of China Daily Chemical Research Institute counter ion quaternary ammonium salt (Hui-cheng Yan, Qiu-xiao Li, Tao Geng, et al. Properties of the Quaternary Ammonium Salts with Novel Counterions. Journal of surfactant and detergent. Journal ofsurfactants and detergents, 2012, 15(5): 953-959), microorganisms have no resistance to it, a small amount of addition can achieve excellent bactericidal and bacteriostatic effects, and the compounding performance with other ingredients is good, and the preparation method is highly operable;

②The main surfactant components used in the present invention—amphoteric surfactants, polyglucosides, and oil ethoxylates are all green surfactants, with good biocompatibility, green safety, and anti-ion quaternary ammonium salts of bactericides. Surfactant with excellent biodegradation performance, the overall formula of the product reflects the green characteristics;

③ The antibacterial hand sanitizer provided by the present invention has good killing ability to Gram-negative bacteria, Gram-positive bacteria and fungi.

Detailed ways

The present invention is further illustrated by the following examples, but is not limited to the following examples.

Example 1

Composition of raw materials: 10 g of bis-dodecyl dimethyl ammonium formate (1.0 wt% active substance); 50 g of dodecyl betaine BS-12; 50 g of polyglucoside APG ₀₈₁₀ ; 15 g of soybean oil ethoxylate ; Glycerin is 10g; Carbomer is 1.0g; Citric acid is 0g; Rose essence is 0.05g; Amaranth red pigment is 0.01g; Water is 863.94g.

Preparation:

First, didecyl dimethyl ammonium formate, dodecyl betaine, APG ₀₈₁₀ , soybean oil ethoxylate, and glycerin were preheated to 60° C. in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 300rpm/min, add 1.0g of carbomer and continue to stir for 20min until the mixture is uniform. Add dodecyl betaine 50g, polyglucoside APG ₀₈₁₀ 50g, soybean oil ethoxylate 15g to the stirring tank successively, and the interval between each feeding is 20min, after adding soybean oil ethoxylate, stir for 20min, and then lower the temperature to 35°C. Then, 10 g of didecyl dimethyl ammonium formate, 10 g of glycerin, 0.05 g of rose essence, 0.01 g of amaranth pigment, and 363.94 g of water were added to the stirring tank in sequence, and the pH of the system was 6.5, and stirring was continued for 60 min. The obtained antibacterial hand sanitizer presents a uniform, amaranth red transparent and viscous liquid state with rose fragrance.

Example 2

Composition of raw materials: 5g of didecyl dimethyl ammonium acetate (1.0wt% active substance); 20g of cocamidopropyl betaine CAB; 80g of polyglucoside APG ₀₈₁₀ ; 10g of soybean oil ethoxylate ; propylene glycol is 15g; sodium carboxymethyl cellulose is 2.0g; citric acid is 0.1g; green tea essence is 0.05g; tender green pigment is 0.01g; water is 867.84g.

Preparation:

First, didecyl dimethyl ammonium acetate, cocamidopropyl betaine, APG ₀₈₁₀ , soybean oil ethoxylate, and propylene glycol were preheated to 60° C. in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 400rpm/min, add 2.0g of sodium carboxymethylcellulose and continue to stir for 20min until the mixture is uniform. Add cocamidopropyl betaine 20g, polyglucoside APG ₀₈₁₀ 80g, soybean oil ethoxylate 10g successively in the stirring tank, and the intermediate interval of each feeding is 20min, after adding the soybean oil ethoxylate, stir 20min, Cool down to 35°C again. Then add 5g of didecyl dimethyl ammonium acetate, 15g of propylene glycol, 0.05g of green tea essence, 0.01g of tender chlorophyll, and 367.84g of remaining water to the stirring tank in turn, and adjust the pH of the system to 6.5 with 0.1g of citric acid. Continue stirring for 60 min. The obtained antibacterial hand sanitizer presented a uniform, light green transparent viscous liquid state with green tea fragrance.

Example 3

Composition of raw materials: 5 g of bis-decyl dimethyl ammonium formate (1.0 wt% active substance); 45 g of cocamidopropyl betaine CAB; 50 g of fatty alcohol ether polyglucoside AEG; palm oil ethoxylate 15g; 5g of glycerin; 0.5g of carbomer; 0.1g of citric acid; 0.05g of lemon essence; 0.01g of tartrazine; 879.34g of water.

Preparation:

First, didecyl dimethyl ammonium formate, cocamidopropyl betaine, AEG, palm oil ethoxylate, and glycerin were preheated to 60° C. in a hot water bath for use. Add 500g of water to a 2000mL stirring tank and heat to 60°C, the stirring speed is 500rpm/min, add 0.5g of carbomer, and continue stirring for 20min until the mixture is uniform. Add cocamidopropyl betaine 45g, fatty alcohol ether polyglucoside AEG 50g, palm oil ethoxylate 15g to the stirring tank successively, and the interval between each feeding is 20min, and after adding the palm oil ethoxylate, stir for 20min , and then cooled to 35°C. Then add 5g of didecyl dimethyl ammonium formate, 5g of glycerin, 0.05g of lemon essence, 0.01g of lemon yellow pigment, and 379.34g of remaining water to the stirring tank in turn, and adjust the pH of the system to 6.5 with 0.1g of citric acid, and continue. Stir for 60 min. The obtained antibacterial hand sanitizer was in a uniform, yellow, transparent and viscous liquid state with lemon fragrance.

Example 4

Composition of raw materials: 10 g of bis-dodecyl dimethyl ammonium formate (1.0 wt% active substance); 20 g of dodecyl betaine BS-12; 80 g of fatty alcohol ether polyglucoside AEG; palm oil ethoxylate 10g; propylene glycol 5g; sodium carboxymethyl cellulose 2.0g; citric acid 0.1g; jasmine essence 0.05g; yellow pigment 0.01g; water 872.84g.

Preparation:

First, didecyl dimethyl ammonium formate, dodecyl betaine, AEG, palm oil ethoxylate, and propylene glycol were preheated to 60° C. in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 500rpm/min, add 2.0g of sodium carboxymethylcellulose, and continue to stir for 20min until the mixture is uniform. Add 20 g of dodecyl betaine, 80 g of fatty alcohol ether polyglucoside AEG, and 10 g of palm oil ethoxylate to the stirring kettle in turn, with an interval of 20 min between each feeding, and stir for 20 min after adding the palm oil ethoxylate. Cool down to 35°C. Then add 10 g of didecyl dimethyl ammonium formate, 5 g of propylene glycol, 0.05 g of jasmine essence, 0.01 g of yellow pigment, and 372.84 g of remaining water to the stirring tank in turn, adjust the pH of the system to 6.5 with 0.1 g of citric acid, and continue to stir 60min. The obtained antibacterial hand sanitizer presents a uniform, yellow, transparent and viscous liquid state with jasmine fragrance.

Example 5

Composition of raw materials: 20g of bisdodecyldimethylammonium nitrate (1.0wt% active substance); 60g of sulfobetaine; 10g of polyglucoside APG ₁₂₁₄ ; 30g of castor oil ethoxylate; 30g of xylitol 30g; alkanolamide 6501 is 1.0g; citric acid is 0.1g; green tea essence is 0.1g; tender green pigment is 0.1g; water is 848.70g.

Preparation:

Firstly, dipecyldimethylammonium nitrate, sulfobetaine, APG ₁₂₁₄ , castor oil ethoxylate and xylitol were preheated to 60°C in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 500rpm/min, add a total of 1.0g of alkanolamide 6501, and continue to stir for 20min until the mixture is uniform. Add 60g of sulfobetaine, 10g of polyglucoside APG ₁₂₁₄ , 30g of castor oil ethoxylate to the stirring tank successively, and the interval between each feeding is 20min, after adding the castor oil ethoxylate, stir for 20min, and then cool down to 35 °C. Then add 20 g of didecyl dimethyl ammonium nitrate, 30 g of xylitol, 0.1 g of green tea essence, 0.1 g of tender green pigment, and 348.7 g of remaining water to the stirring kettle in turn, and adjust the pH of the system to 6.5 with 0.1 g of citric acid. Continue stirring for 60 min. The obtained antibacterial hand sanitizer was in a uniform, green, transparent and viscous liquid state with green tea fragrance.

Example 6

Composition of raw materials: 10g of bis-dodecyl dimethyl ammonium acetate (1.0wt% active substance); 10g of sulfobetaine; 80g of polyglucoside APG ₁₂₁₄ ; 20g of castor oil ethoxylate; 50g of sorbitol ; Alkanolamide 6501 is 2.0g; citric acid is 0g; rose essence is 0.05g; amaranth red pigment is 0.01g; water is 827.94g.

Preparation:

First of all, diladecyl dimethyl ammonium acetate, sulfobetaine, APG ₁₂₁₄ , castor oil ethoxylate, and sorbitol were preheated to 60° C. in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 500rpm/min, add a total of 2.0g of alkanolamide 6501, and continue to stir for 20min until the mixture is uniform. Add 10g of sulfobetaine, 80g of polyglucoside APG ₁₂₁₄ , 20g of castor oil ethoxylate to the stirring tank successively, and the interval between each feeding is 20min, after adding the castor oil ethoxylate, stir for 20min, and then cool down to 35 °C. Then add 10 g of didecyl dimethyl ammonium acetate, 50 g of sorbitol, 0.05 g of rose essence, 0.01 g of amaranth red pigment, and 327.94 g of remaining water into the stirring tank in sequence, the pH of the system is 6.5, and stirring is continued for 60 min. The obtained antibacterial hand sanitizer presents a uniform, light red transparent viscous liquid state with rose fragrance.

Example 7

Composition of raw materials: 2 g of bis-dodecyl dimethyl ammonium acetate (1.0 wt% active substance); 70 g of dodecyl betaine BS-12; 20 g of polyglucoside APG0810; 5 g of castor oil ethoxylate; Xylitol is 40g; carbomer is 2.0g; citric acid is 0.1g; jasmine essence is 0.05g; yellow pigment is 0.01g; water is 860.84g.

Preparation:

First of all, diladecyl dimethyl ammonium acetate, dodecyl betaine, APG ₀₈₁₀ , castor oil ethoxylate, and xylitol were preheated to 60° C. in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 500rpm/min, add a total of 2.0g of carbomer, and continue to stir for 20min until the mixture is uniform. Adding dodecyl betaine BS-12 to the stirring tank successively is 70g, polyglucoside APG0810 is 20g, and castor oil ethoxylate is 5g, and the interval between each feeding is 20min, after adding the castor oil ethoxylate After stirring for 20 min, the temperature was lowered to 35°C. Then add 2 g of didecyl dimethyl ammonium acetate, 40 g of xylitol, 0.05 g of jasmine essence, 0.01 g of yellow pigment, and 360.84 g of remaining water to the stirring tank in turn, and adjust the pH of the system to 6.5 with 0.1 g of citric acid. Continue stirring for 60 min. The obtained antibacterial hand sanitizer is in a uniform, yellow transparent viscous liquid state with jasmine fragrance.

Example 8

Composition of raw materials: 10g of bis-decyldimethylammonium nitrate (1.0wt% active); 10g of cocamidopropyl betaine CAB; 50g of polyglucoside APG ₁₂₁₄ ; 20g of palm oil ethoxylate ; Sorbitol is 30g; Hydroxyethylcellulose is 1.0g; Citric acid is 0.05g; Lemon essence is 0.05g; Lemon yellow pigment is 0.01g; Water is 878.89g.

Preparation:

First of all, preheat bisdodecyl dimethyl ammonium nitrate, cocamidopropyl betaine, APG ₁₂₁₄ , palm oil ethoxylate and sorbitol to 60°C in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 500rpm/min, add 1.0g of hydroxyethyl cellulose, a total of 1.0g, and continue to stir for 20min until the mixture is uniform. Adding cocamidopropyl betaine CAB to the stirring tank successively is 10g, polyglucoside APG ₁₂₁₄ is 50g, and palm oil ethoxylate is 20g, and the intermediate interval of each feeding is 20min, and the palm oil ethoxylate is added. After stirring for 20 min, the temperature was lowered to 35 °C. Then add 10 g of didecyl dimethyl ammonium nitrate, 30 g of sorbitol, 0.05 g of lemon essence, 0.01 g of lemon yellow pigment, and 378.89 g of remaining water to the stirring kettle in turn, and adjust the pH of the system to 6.5 with 0.05 g of citric acid. Continue stirring for 60 min. The obtained antibacterial hand sanitizer was in a uniform, yellow, transparent and viscous liquid state with lemon fragrance.

Example 9

Composition of raw materials: 20g of bis-dodecyldimethylammonium nitrate (1.0wt% active substance); 40g of sulfobetaine; 20g of fatty alcohol ether polyglucoside AEG; 30g of soybean oil ethoxylate; 15g; hydroxyethyl cellulose 0.3g; citric acid 0.05g; green tea essence 0.05g; tender green pigment 0.01g; water 874.59g.

Preparation:

First, dipecyldimethylammonium nitrate, sulfobetaine, AEG, soybean oil ethoxylate, and glycerin were preheated to 60° C. in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 500rpm/min, add 0.3g of hydroxyethyl cellulose, and continue to stir for 20min until the mixture is uniform. Add 40 g of sulfobetaine, 20 g of fatty alcohol ether polyglucoside AEG, and 30 g of soybean oil ethoxylate to the stirring tank successively. Cool down to 35°C. Then add 20 g of didecyl dimethyl ammonium nitrate, 15 g of glycerol, 0.05 g of green tea essence, 0.01 g of green pigment, and 374.59 g of remaining water to the stirring tank in turn, adjust the pH of the system to 6.5 with 0.05 g of citric acid, and continue to stir. 60min. The obtained antibacterial hand sanitizer was in a uniform, green, transparent and viscous liquid state with green tea fragrance.

Example 10

Raw material composition: bis-dodecyl dimethyl ammonium formate (1.0wt% active substance) is 5g; bis-dodecyl dimethyl ammonium acetate (1.0wt% active substance) is 5g; dodecyl betaine BS-12 50g; polyglucoside APG ₀₈₁₀ is 50g; soybean oil ethoxylate is 15g; glycerin is 10g; carbomer is 1.0g; citric acid is 0g; rose essence is 0.05g; is 863.94g.

Preparation:

First preheat bis-dodecyl dimethyl ammonium formate, bis-dodecyl dimethyl ammonium acetate, dodecyl betaine, APG ₀₈₁₀ , soybean oil ethoxylate, glycerin to 60°C in a hot water bath spare. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 300rpm/min, add 1.0g of carbomer and continue to stir for 20min until the mixture is uniform. Add dodecyl betaine 50g, polyglucoside APG ₀₈₁₀ 50g, soybean oil ethoxylate 15g to the stirring tank successively, and the interval between each feeding is 20min, after adding soybean oil ethoxylate, stir for 20min, and then lower the temperature to 35°C. Then add 5 g of bis-dodecyl dimethyl ammonium formate, 5 g of bis-dodecyl dimethyl ammonium acetate, 10 g of glycerin, 0.05 g of rose essence, 0.01 g of amaranth red pigment, and 363.94 g of residual water into the stirring tank in turn. pH=6.5 and continue stirring for 60min. The obtained antibacterial hand sanitizer presents a uniform, amaranth red transparent and viscous liquid state with rose fragrance.

Example 11

Composition of raw materials: bis-dodecyl dimethyl ammonium acetate (1.0wt% active substance) is 3g, bis-dodecyl dimethyl ammonium nitrate (1.0wt% active substance) is 2g; cocamidopropyl betaine CAB 20g; polyglucoside APG ₀₈₁₀ is 80g; soybean oil ethoxylate is 10g; propylene glycol is 15g; sodium carboxymethyl cellulose is 2.0g; citric acid is 0.1g; green tea essence is 0.05g; g; water is 867.84 g.

Preparation:

First preheat bis-dodecyl dimethyl ammonium acetate, bis-dodecyl dimethyl ammonium nitrate, cocamidopropyl betaine, APG ₀₈₁₀ , soybean oil ethoxylate, propylene glycol in a hot water bath to Reserve at 60°C. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 400rpm/min, add 2.0g of sodium carboxymethylcellulose and continue to stir for 20min until the mixture is uniform. Add cocamidopropyl betaine 20g, polyglucoside APG ₀₈₁₀ 80g, soybean oil ethoxylate 10g successively in the stirring tank, and the intermediate interval of each feeding is 20min, after adding the soybean oil ethoxylate, stir 20min, Cool down to 35°C again. Then add 3 g of bis-dodecyl dimethyl ammonium acetate, 2 g of bis-dodecyl dimethyl ammonium nitrate, 15 g of propylene glycol, 0.05 g of green tea essence, 0.01 g of tender leaf green pigment, and 367.84 g of residual water to the stirring kettle in turn, The pH of the system was adjusted to 6.5 with 0.1 g of citric acid, and stirring was continued for 60 min. The obtained antibacterial hand sanitizer presented a uniform, light green transparent viscous liquid state with green tea fragrance.

Example 12

Composition of raw materials: dodecyl/tetradecyldimethylbenzyl ammonium chloride (1227, 1.0wt% active substance) is 5g; dodecyl betaine BS-12 is 50g; polyglucoside APG ₀₈₁₀ is 50g; Soybean oil ethoxylate is 15g; glycerin is 10g; carbomer is 1.0g; citric acid is 0g; rose essence is 0.05g; amaranth pigment is 0.01g; water is 868.94g.

Preparation:

First, dodecyl/tetradecyl dimethyl benzyl ammonium chloride, dodecyl betaine, APG ₀₈₁₀ , soybean oil ethoxylate, and glycerin were preheated to 60° C. in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 300rpm/min, add 1.0g of carbomer and continue to stir for 20min until the mixture is uniform. Add dodecyl betaine 50g, polyglucoside APG ₀₈₁₀ 50g, soybean oil ethoxylate 15g to the stirring tank successively, and the interval between each feeding is 20min, after adding soybean oil ethoxylate, stir for 20min, and then lower the temperature to 35°C. Then add dodecyl/tetradecyldimethylbenzyl ammonium chloride 5g, glycerin 10g, rose essence 0.05g, amaranth red pigment 0.01g, balance water 368.94g to the stirring tank in turn, and the system pH=6.5 to continue stirring 60min. The obtained antibacterial hand sanitizer presents a uniform, amaranth red transparent and viscous liquid state with rose fragrance.

Example 13

Composition of raw materials: 50g of dodecyl betaine BS-12; 50g of polyglucoside APG ₀₈₁₀ ; 15g of soybean oil ethoxylate; 10g of glycerin; 1.0g of carbomer; 0g of citric acid; rose essence is 0.05g; amaranth red pigment is 0.01g; water is 873.94g.

Preparation:

First, dodecyl betaine, APG ₀₈₁₀ , soybean oil ethoxylate and glycerin were preheated to 60°C in a hot water bath for use. Add 500g of water to a 2000mL stirred tank and heat to 60°C, the stirring speed is 300rpm/min, add 1.0g of carbomer and continue to stir for 20min until the mixture is uniform. Add dodecyl betaine 50g, polyglucoside APG ₀₈₁₀ 50g, soybean oil ethoxylate 15g to the stirring tank successively, and the interval between each feeding is 20min, after adding soybean oil ethoxylate, stir for 20min, and then lower the temperature to 35°C. Then, 10 g of glycerin, 0.05 g of rose essence, 0.01 g of amaranth pigment, and 373.94 g of remaining water were added to the stirring kettle in sequence, and the pH of the system was 6.5 and stirring was continued for 60 min. The obtained antibacterial hand sanitizer presents a uniform, amaranth red transparent and viscous liquid state with rose fragrance.

Table 1 Statistical table of performance test results of specific embodiments

※Performance test method:

1. The temperature resistance test is tested according to the requirements of GB/T 34855-2017 "Hand Sanitizer". Among them, the high temperature resistance test is placed in a constant temperature box of 40 ± 2 °C for 24 hours, and it is taken out and returned to room temperature without delamination, transparency and turbidity. ; Low temperature resistance test Put it in a constant temperature box of -5±2℃ for 24 hours, take it out and return to room temperature without delamination, crystallization, transparency and no turbidity.

2. The antibacterial performance test is in accordance with the requirements of the light industry standard QB/T 2738-2012 "Evaluation Method for Antibacterial and Bacteriostatic Effect of Daily Chemical Products".

3. Storage stability: The product can be stored at room temperature for one year without delamination, crystallization, transparency and no turbidity.

Claims (8)

1. An antibacterial hand sanitizer containing counter ion quaternary ammonium salt is characterized by comprising the following raw materials in percentage by weight:

1.0-7.0% of an amphoteric surfactant;

1.0-8.0% of polyglucoside;

0.5-3.0% of grease ethoxylate;

0.2-2.0% of counter-ion quaternary ammonium salt;

0.5-5.0% of a humectant;

0.03-0.2% of a thickening agent;

0-0.01% of a pH regulator;

0-0.1% of essence;

0-0.01% of pigment;

the balance of water;

wherein, the counter ion quaternary ammonium salt has a general formula:

in the formula: r₁、R₂Is an alkyl chain with 8-14 carbon atoms; x is NO₃HCOO or CH₃(CH₂)_nCOO, n is an integer between 0 and 6;

the counter-ion quaternary ammonium salt is any one of the compounds or the mixture of the compounds;

the counter-ion quaternary ammonium salt accounts for 0.5-1.5 wt% of the total amount of the raw materials.

2. The bacteriostatic hand sanitizer containing the counter-ion quaternary ammonium salt according to claim 1, characterized in that: the amphoteric surfactant is one or a mixture of betaine surfactants, and the betaine surfactants comprise one of alkyl betaine, amido propyl betaine and sulfobetaine;

wherein, in the alkyl betaine, the number of alkyl carbon atoms is 8-18; the amido propyl betaine has 8-22 amido carbon atoms and contains unsaturated amido with carbon-carbon double bond.

3. The bacteriostatic hand sanitizer containing the counter ion quaternary ammonium salt according to claim 2, which is characterized in that: the betaine surfactant is a betaine surfactant with 10-14 carbon atoms, and accounts for 3.0% -5.0% of the total weight of the raw materials.

4. The bacteriostatic hand sanitizer containing the counter ion quaternary ammonium salt according to claim 1, which is characterized in that: the polyglucoside is a compound having the following general formula:

in the formula: n is an integer of 1 to 3; r comprises any of two of: a linear alkyl chain or a branched alkyl chain with 8-22 carbon atoms; shaped like- (CH)₂CH₂O)_mR₁Fatty alcohol polyoxyethylene ether chain with structure, m = integer between 1-9, R₁The alkyl group is a straight-chain alkyl or branched-chain alkyl with 8-22 carbon atoms;

the polyglucoside accounts for 1.0-8.0% of the raw materials by weight.

5. The bacteriostatic hand sanitizer containing the counter ion quaternary ammonium salt according to claim 1, which is characterized in that: the polyglucoside is a compound having the following general formula:

in the formula: n is an integer between 1 and 3; r comprises any of two of: a linear or branched alkyl chain having 8 to 14 carbon atoms in the form of: - (CH)₂CH₂O)_mR₁Fatty alcohol polyoxyethylene ether chain with structure, m = integer between 1-9, R₁The alkyl group is a straight-chain alkyl or branched-chain alkyl with 8-14 carbon atoms;

the polyglucoside accounts for 4.0-6.0% of the raw materials by weight.

6. The bacteriostatic hand sanitizer containing the counter ion quaternary ammonium salt according to claim 1, which is characterized in that: the grease ethoxylate is one or a composition of more of palm kernel oil ethoxylate, palm oil ethoxylate, castor oil ethoxylate, soybean oil ethoxylate, cottonseed oil ethoxylate, rapeseed oil ethoxylate and coconut oil ethoxylate; the grease ethoxylate accounts for 0.5-2.0% of the total weight of the raw materials;

the humectant is one or more of glycerol, propylene glycol, butanediol, xylitol and sorbitol;

the thickening agent is one or more of sodium carboxymethylcellulose, hydroxyethyl cellulose, carbomer and 6501;

the pH regulator is as follows: citric acid;

the essence is as follows: one of green tea, lavender, jasmine flower fragrance and rose;

the pigment is as follows: amaranth pigment, tender green pigment, lemon yellow pigment, and yellow pigment.

7. A preparation method of the antibacterial hand sanitizer containing the counter-ion quaternary ammonium salt according to any one of claims 1 to 6 is characterized by comprising the following steps:

melting the raw materials in a hot water bath; adding 50% of water into a container, heating the water to 60 ℃, adding the thickening agent into the container, and stirring and mixing the mixture uniformly; sequentially adding the amphoteric surfactant, the polyglucoside and the grease ethoxylate into a container, stirring until all raw materials are completely dissolved, and cooling to 30-40 ℃; adding counter ion quaternary ammonium salt, humectant, pigment and essence, adjusting pH with pH regulator, adding the rest water, and stirring to obtain the antibacterial hand sanitizer.

8. The preparation method of the antibacterial hand sanitizer containing the counter-ion quaternary ammonium salt according to claim 7, characterized by comprising the following steps:

melting the raw materials in a hot water bath according to the weight percentage, and controlling the temperature of the hot water bath at 60-70 ℃;

adding 50% of water into a container, stirring, heating the water to 60 ℃, adding the thickening agent into the container, and stirring until the thickening agent is dissolved;

sequentially adding the amphoteric surfactant, the polyglucoside and the grease ethoxylate into a container, stirring, and cooling to 30-40 ℃ after all raw materials are completely dissolved;

adding counter ion quaternary ammonium salt, humectant, pigment and essence, adjusting the pH value to 6.3-6.7 by using a pH regulator, adding the balance of water, and uniformly stirring to obtain the antibacterial hand sanitizer.