CN110151650A - A kind of Red blood streak dispelling lotion and preparation method thereof of the ingredient of composite reactive containing horse chestnut - Google Patents
A kind of Red blood streak dispelling lotion and preparation method thereof of the ingredient of composite reactive containing horse chestnut Download PDFInfo
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- CN110151650A CN110151650A CN201910471946.9A CN201910471946A CN110151650A CN 110151650 A CN110151650 A CN 110151650A CN 201910471946 A CN201910471946 A CN 201910471946A CN 110151650 A CN110151650 A CN 110151650A
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- parts
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- red blood
- ingredient
- lotion
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Abstract
The present invention discloses a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut, by weight, including following components: component A: carbomer, xanthan gum, -6/ tert-butyl alcohol of polyacrylate cross-linked polymer, moisturizer, Sodium Hyaluronate, polyethylene glycol-8, deionized water；B component: emulsifier, dimethyl silicone polymer, caprylic/capric triglyceride, pentaerythritol tetraoctyl stearate, lauric alcohol-caprylate/decylate, cetostearyl alcohol, phytosterol isostearate；Component C: pH adjusting agent；D component: preservative, polyalcohol；Component E: panthenol, heparin sodium.The present invention without pigment, without ethyl alcohol, mildly do not stimulate, it is without side-effects, facial blood circulation can be effectively improved, Shu Min myogenic, nourish moisturizing, while conserving face skin, it is effectively improved red blood trace on face symptom, induction type red capillary is alleviated in treatment, can meet the needs of people are to natural, green, healthy, effect skin care item.
Description
Technical field
The present invention relates to a kind of Red blood streak dispelling lotions and preparation method thereof of ingredient of composite reactive containing horse chestnut, belong to makeup
Product field.
Background technique
In recent years, the skin problem that skin sensitivity caused is increasingly becoming the hot spot of cosmetics and medical industries research.Wherein,
The red capillary that facial telangiectasias causes not only seriously affects patient's beauty, but also also results in the psychology of patient very big negative
Load.It is also higher and higher for the quality and performance requirement of cosmetics with the continuous improvement of social development living standards of the people.
Red blood trace on face, medically also known as facial telangiectasias, that is, the elasticity reduction of capillary wall are crisp
Property enhancing, the non-uniform expansion of continuous vessel even ruptures, and causes skin of face general red, the blood capillary of the visible expansion of naked eyes
Pipe, be often accompanied by red or aubergine plaque-like, it is dotted, linear or starlike phenomena such as, referred to as telangiectasia.This skin is thin
And it is sensitive, face is redder when supercooling, overheat, excited, temperature suddenly change.Red blood trace on face patient facial region seems than one
As normal skin tone it is red, some be only two sides cheekbone portion it is rubescent, boundary is rounded.This skin is thin and sensitive, supercooling, overheat, feelings
Face is redder when thread excitement.Serious person also will form deposition color spot, it is difficult to cure, not only influence the beauty of appearance, can also give
Psychology causes shade, brings great inconvenience to normal life.
As the improvement of people's living standards, requirement of the people to beautifying skin quality is also being continuously improved, emphasizing to imitate
Safety is paid much attention to while fruit.Obvious, the safe Red blood streak dispelling cosmetics of development effectiveness, it has also become current beauty industry
Hot spot, and the active Chinese drug component object of plant origin is its main direction of studying.
Horse chestnut, deciduous tree, it is tree-like it is graceful, spend it is big it is beautiful, fruit shape is peculiar, be the good tree species of leaf, flower, Guo Jianshang,
For one of world-renowned ornamental tree.Horse chestnut have it is stronger lay the dust, sound insulation, the ability for absorbing pernicious gas, and can be to prevent
The solid soil of sand reduces soil erosion, and Sync enrichment soil nutrient improves soil texture, promotes the benign cycle of soil nutrient.Green
While changing beautifying urban environment, it can be also obviously improved the ecological environment in urban district, that improves city rids calamities and combat a natural disaster performance.From seven
The active skull cap components of Ye Shuzhong extraction: 1. aescin, by inhibiting Collagenase etc. close with skin pattern and integrality
Relevant enzyme promotes microcirculation, maintains cell eubolism, so that pore is promoted to restrain, it is clean, it nourishes, keeps skin careful
It is flawless.2. Ba 2672 can protect arteries and structural integrity, improves vein function, combine anti-inflammatory and anti-oxidant
Deng performance multi-efficiency；Inhibit Collagenase, hyaluronidase, B- glucuronidase and pancreatopeptidase E (can catalytic destruction vein
The exudation of the integrality of structure and stingy capillary) effect be also proved；Can be played in external prescription promote blood circulation,
Promote wound healing, antioedematous, it is anti-inflammatory it is impervious go out and vascular protection effect (go black eye, go red capillary, is crease-resistant, maintenance).It is
In conker it is most important mitigate inflammation ingredient, it by fill up veinlet and capillary microscopic nicks and it is subtle can
The gap seen can effectively improve the integrality of blood vessel astillen, therefore Ba 2672 helps to repair capillary.
Summary of the invention
In view of the above existing problems in the prior art, the present invention provides a kind of red blood of dispelling of ingredient of composite reactive containing horse chestnut
Silk lotion, quality is milky white pure and fresh, and water profit easily absorbs and can be effectively improved microcirculation, and Shu Min myogenic nourishes moisturizing, is effectively improved face
Induction type red capillary is alleviated in portion's red capillary symptom, treatment, complies with the theory and the market demand of the addition of people's green, healthy skin care.
The present invention also provides the preparation methods of the Red blood streak dispelling lotion.
To achieve the goals above, a kind of Red blood streak dispelling lotion for ingredient of composite reactive containing horse chestnut that the present invention uses,
By weight, including following components:
Component A: 0.01-0.5 parts of carbomer, 0.05-0.5 parts of xanthan gum, -6/ tert-butyl alcohol of polyacrylate cross-linked polymer
0.01-0.2 parts, 3-10 parts of moisturizer, 0.01-0.2 parts of Sodium Hyaluronate, 0.5-3 parts of polyethylene glycol-8, deionized water adds to
100 parts；
B component: 1.5-5 parts of emulsifier, 0.1-2 parts of dimethyl silicone polymer, 1-5 parts of caprylic/capric triglyceride, season penta
1-3 parts of tetrol pentaerythritol tetraisostearate, lauric alcohol-caprylate/0.5-2 parts of decylate, 0.5-3 parts of cetostearyl alcohol, phytosterol
0.2-1 parts of isostearate；
Component C: 0.01-0.3 parts of pH adjusting agent；
D component: 0.2-1.5 parts of preservative, 0.5-3 parts of polyalcohol；
Component E: 0.5-3 parts of panthenol, 0.01-0.5 parts of heparin sodium, 0.1-3 parts of De Minshu active constituent, tetrahydro methylpyrimidine
0.5-2 parts of carboxylic acid, high mountain plants active component 0.1-0.5 parts of extraction, 0.1-3 parts of horse chestnut composite reactive ingredient, essence 0.01-0.2
Part.
The moisturizer is one of glycerol, 1,3 butylene glycol, dipropylene glycol, sorbierite, trehalose or a variety of mixed
It closes.
The emulsifier is stearine SE, polysorbate -20, sucrose stearate/sucrose, stearoyl-glutamic acid
One or more mixing of sodium.
The pH adjusting agent is one of triethanolamine, arginine, tromethamine or a variety of mixing.
The preservative is 1,2- pentanediol, parahydroxyacet-ophenone, Phenoxyethanol, 1,2- hexylene glycol, methyl hydroxybenzoate or hydroxyl
One of phenylpropyl alcohol ester or a variety of mixing.
The polyalcohol is glycerol, dipropylene glycol, butanediol, propylene glycol, and 1,2- pentanediol, diglycerol are one or more mixed
It closes.
It is HERBA DENDROBII stem extraction, Angelica roots, Herba Verbenae, Radix Notoginseng that the high mountain, which plants extraction active component,
Root extract, tomonea extract, Chinese herbaceous peony root extract compound.
The De Minshu active constituent includes hydroxy phenylpropionyl amine benzoic acid, ascorbyl palmitate.
The horse chestnut composite reactive ingredient be panthenol, Ba 2672, glycerol, butcher's broom root extract, ammonium glycyrrhetate,
The compound of accumulated snow leaf extract, hydrolyzed yeast albumen and pot marigold flower extract.
In addition, the present invention also provides a kind of preparation methods of Red blood streak dispelling lotion, comprising the following steps:
1) component A is put into water phase pot, is heated with stirring to 80-85 DEG C, made it dissolve completely；
2) B component is put into oily phase pot, is heated with stirring to 80-85 DEG C, homogeneous makes it dissolve completely；
3) water phase material and oil phase material are sucked in succession in emulsifying kettle, keeps 80-85 DEG C of homogeneous 1-3min of temperature, heat preservation
Stirring cooling after ten minutes；
4) when temperature drops to 60 DEG C, component C is added；
5) when temperature drops to 50 DEG C, the good D component of predissolve is added；
6) when temperature drops to 40 DEG C, stop agitation and filtration discharging.
The performance or the mechanism of action of used part primary raw material are as follows in inventive formulation:
High mountain plants the Chinese medicine skin makeup that extraction is derived from the Yunnan genunie medicinal materials such as the plant HERBA DENDROBII, Radix Angelicae Sinensis, Radix Notoginseng in Yunnan composition
Side is compounded according to the prescription thought of Traditional Chinese Medicine " monarch, minister, help, make ", is had good antioxidant activity and is inhibited junket ammonia
Phytase activity, and have the function of good improvement skin microcirculation, good moist skin, balanced pigment and nourishing can be played
The effect of skin.
Sodium Hyaluronate is a kind of acid mucopolysaccharide, is naturally present in cornea skin, can absorb itself 1000 times of weight
Moisture is lost by retaining moisture of skin, prevention moisture through epidermis with reaching, and the barrier when skin is damaged is repaired
It is multiple, enable skin not feel drying after, increase gloss, it can improve skin-nourishing metabolism, make skin it is soft, it is smooth, go
Wrinkle increases elasticity, prevents aging, is good skin penetration enhancer again while moisturizing.Cooperate with other nutritional ingredients
It uses, the more preferable effect for promoting nutrient absorption can be played.
Panthenol is also known as dexpanthenol, is mainly used as moisturizer and skin conditioning agent, is used together with vitamin B6, percutaneously
Skin can increase hyaluronic acid contents in skin after absorbing, promote the metabolism of human body protein, fat, carbohydrate, protect skin and stick
Film prevents and treats small wrinkle, and inflammation, solarization are not glutinous greasy moisturizing ingredients, have potent moistening effect, and with skin sebum film phase
Closely, it is easy to absorb infiltration and infiltrates the cuticula of skin surface, keeps skin soft, effectively prevent the coarse phenomenon of skin, reach flesh
The effect of skin moisturizing and tissue repair, gives skin gloss.
De Minshu active constituent (present invention use De Minshu SymCalmin 143535) be hydroxy phenylpropionyl amine benzoic acid,
The effective components compound such as ascorbyl palmitate, efficient anti-irritant active constituent have antioxidant activity and antihistamine
Activity effectively mitigates inflammatory symptom and slows down scratchiness and erythema.
Heparin sodium increases the vasopermeability of skin, improves the effect of local vascular circulation, promotes the supply of skin-nourishing
It is drained with metabolic waste, good health-care effect is played to skin.
Tetrahydro methylpyrimidine carboxylic acid is a kind of amino acid derivativges, has powerful resistance to compression defencive function；Around fettering
Hydrone forms complex, is wrapped in around cell, enzyme, protein and other organic molecules, and being formed has protection, nourishes and steady
The protective shell of aquation is determined, to prevent cellular damage；It can protect the Langerhans cell of UV irradiated skin；It is not filtered
Light action will not absorb ultraviolet light, but one layer of protective shell is formed around Skin Cell and skin histology, in cell rank
Prevent skin by the radiation injury of long wave, ultraviolet B radiation, infrared ray and visible light.
Phytosterol isostearate has excellent holding moisture and moisture-keeping efficacy, the height attachment of skin and hair,
It can be used in daily chemical products as emollients, to the good dispersion of inorganic pigment.It can also be used as emulsifier use.
Horse chestnut composite reactive ingredient (present invention uses Biophytex LS 9832 (BASF)) can significantly improve and hair
Thin nagiopasthyrosis and the not good enough relevant face skin problem of microcirculation the problem of especially for below eye, pass through reinforcing
Capillary wall improves microcirculation to reach and reduces spider line, reduces black eye, plays the role of releiving, calm skin, separately
It can also promote microcirculation outside, improve skin tolerance；
Compared with prior art, Red blood streak dispelling lotion of the invention is mainly made of matrix components and active functional component.
Active functional component mixed with improve skin microcirculation functions horse chestnut composite reactive ingredient and heparin sodium high activity at
Point, effectively facilitate blood circulation it is unimpeded, increase skin vasopermeability, improve local vascular circulation effect, nourish skin；
Panthenol and De Minshu isoreactivity ingredient with anti-oxidant anti-inflammatory efficacy, the skin for releiving stimulated and stimulation epithelium are also contained
It generates, effectively mitigate inflammatory symptom and slows down scratchiness and erythema, help minor cut or wound healing；Special isostearate containing phytosterol
Sodium Hyaluronate is cooperateed with, from inside to outside, regulating water quality membrane equilibrium, moisturizing more water lock, moisturizing maintenance thickens cutin；It is equipped with four again
Hydrogen methylpyrimidine carboxylic acid, high mountain plant the efficient ingredients such as extraction, and full protection, reparation, nourishing and reinforcing skin assign user's health
Water moisturizes bright skin.Lotion quality of the invention is milky white pure and fresh, and water profit easily absorbs and can be effectively improved microcirculation, Shu Minsheng
Flesh nourishes moisturizing, is effectively improved red blood trace on face symptom, and induction type red capillary is alleviated in treatment, complies with the addition of people's green, health
The theory and the market demand of skin care.
The present invention without pigment, without ethyl alcohol, mildly do not stimulate, it is without side-effects, facial blood circulation can be effectively improved, it is easypro
Quick myogenic nourishes moisturizing, while conserving face skin, is effectively improved red blood trace on face symptom, it is red that induction type is alleviated in treatment
The trace of blood can meet the needs of people are to natural, green, healthy, effect skin care item.
Detailed description of the invention
Fig. 1 is the liquid crystal picture that sample of the present invention is observed at Olympus BX51,400 times；
Fig. 2 is the cuticula moisture content mean variation curve of subject of the present invention；Wherein A is left face cuticula moisture
Changes of contents, B are right face cuticula moisture content change；
Fig. 3 is the fluid loss mean variation curve of subject of the present invention；Wherein A is the variation of left face fluid loss, and B is right face
Fluid loss variation；
Fig. 4 is the content of hemachrome mean variation curve of subject of the present invention；Wherein A is the change of left face content of hemachrome
Change, B is the variation of right face content of hemachrome；
Fig. 5 is the L value mean variation curve of subject of the present invention；Wherein A is the variation of left face L value, and B is the change of right face L value
Change；
Fig. 6 is the A value mean variation curve of subject of the present invention；Wherein A is the variation of left face A value, and B is the change of right face A value
Change；
Fig. 7 is the ITA value mean variation curve of subject of the present invention；Wherein A is the variation of left face ITA value, and B is right face
The variation of ITA value.
Specific embodiment
In order to make the objectives, technical solutions and advantages of the present invention clearer, the present invention is carried out below further detailed
It describes in detail bright.However, it should be understood that the specific embodiments described herein are merely illustrative of the present invention, it is not limited to this hair
Bright range.
Unless otherwise defined, all technical terms and scientific terms used herein are led with technology of the invention is belonged to
The normally understood meaning of the technical staff in domain is identical, and term as used herein in the specification of the present invention is intended merely to retouch
State the purpose of specific embodiment, it is not intended that in the limitation present invention.
Embodiment 1
A kind of Red blood streak dispelling lotion of the ingredient of composite reactive containing horse chestnut, by weight, including following components:
Component A: 0.01 part of carbomer, 0.05 part of xanthan gum, 0.01 part of -6/ tert-butyl alcohol of polyacrylate cross-linked polymer,
3 parts of moisturizer, 0.01 part of Sodium Hyaluronate, 0.5 part of polyethylene glycol-8, deionized water adds to 100 parts；
B component: 1.5 parts of emulsifier, 0.1 part of dimethyl silicone polymer, 1 part of caprylic/capric triglyceride, pentaerythrite four
1 part of isostearate, lauric alcohol -0.5 part of caprylate/decylate, 0.5 part of cetostearyl alcohol, phytosterol isostearate 0.2
Part；Component C: 0.01 part of pH adjusting agent；D component: 0.2 part of preservative, 0.5 part of polyalcohol；
Component E: 0.5 part of panthenol, 0.01 part of heparin sodium, 0.1 part of De Minshu active constituent, tetrahydro methylpyrimidine carboxylic acid 0.5
Part, 0.1 part of active component of extraction of high mountain plant, 0.1 part of horse chestnut composite reactive ingredient, 0.01 part of essence.
The moisturizer is the mixing of glycerol, 1,3 butylene glycol.The emulsifier is stearine SE.
The pH adjusting agent is triethanolamine.The preservative is 1,2- pentanediol.
The polyalcohol is the mixing of glycerol, butanediol.
It is HERBA DENDROBII stem extraction, Angelica roots, Herba Verbenae, Radix Notoginseng that the high mountain, which plants extraction active component,
Root extract, tomonea extract, Chinese herbaceous peony root extract compound.
The De Minshu active constituent is answering for the effective components such as hydroxy phenylpropionyl amine benzoic acid, ascorbyl palmitate
Close object.The present invention uses De Minshu SymCalmin 143535.
The horse chestnut composite reactive ingredient be panthenol, Ba 2672, glycerol, butcher's broom root extract, ammonium glycyrrhetate,
The compound of accumulated snow leaf extract, hydrolyzed yeast albumen and pot marigold flower extract.The present invention uses Biophytex LS
9832 (BASF).
The preparation method of the Red blood streak dispelling lotion, comprising the following steps:
1) component A is put into water phase pot, is heated with stirring to 80 DEG C, made it dissolve completely；
2) B component is put into oily phase pot, is heated with stirring to 80 DEG C, homogeneous makes it dissolve completely；
3) water phase material and oil phase material are sucked in succession in emulsifying kettle, keeps 80 DEG C of homogeneous 1min of temperature, keep the temperature 10 points
Cooling is stirred after clock；
4) when temperature drops to 60 DEG C, component C is added；
5) when temperature drops to 50 DEG C, the good D component of predissolve is added；
6) when temperature drops to 40 DEG C, stop agitation and filtration discharging.
Embodiment 2
A kind of Red blood streak dispelling lotion of the ingredient of composite reactive containing horse chestnut, by weight, including following components:
Component A: 0.3 part of carbomer, 0.3 part of xanthan gum, 0.1 part of -6/ tert-butyl alcohol of polyacrylate cross-linked polymer, moisturizing
5 parts of agent, 0.1 part of Sodium Hyaluronate, 2 parts of polyethylene glycol-8, deionized water adds to 100 parts；
B component: 3.5 parts of emulsifier, 1 part of dimethyl silicone polymer, 3 parts of caprylic/capric triglyceride, pentaerythrite four is different
2 parts of stearate, lauric alcohol -1 part of caprylate/decylate, 2 parts of cetostearyl alcohol, 0.5 part of phytosterol isostearate；
Component C: 0.1 part of pH adjusting agent；
D component: 1 part of preservative, 1.5 parts of polyalcohol；
Component E: 1 part of panthenol, 0.3 part of heparin sodium, 1 part of De Minshu active constituent, 1 part of tetrahydro methylpyrimidine carboxylic acid, high mountain
0.3 part of active component of plant extraction, 2 parts of horse chestnut composite reactive ingredient, 0.1 part of essence.
The moisturizer is dipropylene glycol.The emulsifier is polysorbate -20.
The pH adjusting agent is arginine.The preservative is Phenoxyethanol.The polyalcohol is butanediol, diglycerol.
It is HERBA DENDROBII stem extraction, Angelica roots, Herba Verbenae, Radix Notoginseng that the high mountain, which plants extraction active component,
Root extract, tomonea extract, Chinese herbaceous peony root extract compound.
The De Minshu active constituent is answering for the effective components such as hydroxy phenylpropionyl amine benzoic acid, ascorbyl palmitate
Close object.The present invention uses De Minshu SymCalmin 143535.The horse chestnut composite reactive ingredient is panthenol, horse chestnut soap
Glycosides, glycerol, butcher's broom (RUSCUS ACULEATUS) root extract, ammonium glycyrrhetate, centella (CENTELLA ASIATICA) leaf
The compound of extract, hydrolyzed yeast albumen and pot marigold (CALENDULA OFFICINALIS) flower extract.The present invention uses
Biophytex LS 9832 (BASF).
The preparation method of the Red blood streak dispelling lotion, comprising the following steps:
1) component A is put into water phase pot, is heated with stirring to 83 DEG C, made it dissolve completely；
2) B component is put into oily phase pot, is heated with stirring to 83 DEG C, homogeneous makes it dissolve completely；
3) water phase material and oil phase material are sucked in succession in emulsifying kettle, keeps 83 DEG C of homogeneous 2min of temperature, keep the temperature 10 points
Cooling is stirred after clock；
4) when temperature drops to 60 DEG C, component C is added；
5) when temperature drops to 50 DEG C, the good D component of predissolve is added；
6) when temperature drops to 40 DEG C, stop agitation and filtration discharging.
Embodiment 3
A kind of Red blood streak dispelling lotion of the ingredient of composite reactive containing horse chestnut, by weight, including following components:
Component A: 0.5 part of carbomer, 0.5 part of xanthan gum, 0.2 part of -6/ tert-butyl alcohol of polyacrylate cross-linked polymer, moisturizing
10 parts of agent, 0.2 part of Sodium Hyaluronate, 3 parts of polyethylene glycol-8, deionized water adds to 100 parts；
B component: 5 parts of emulsifier, 2 parts of dimethyl silicone polymer, 5 parts of caprylic/capric triglyceride, pentaerythrite four is different hard
2.5 parts of resin acid ester, lauric alcohol -1.8 parts of caprylate/decylate, 2.5 parts of cetostearyl alcohol, 1 part of phytosterol isostearate；
Component C: 0.3 part of pH adjusting agent；
D component: 1.5 parts of preservative, 3 parts of polyalcohol；
Component E: 3 parts of panthenol, 0.5 part of heparin sodium, 2.5 parts of De Minshu active constituent, 2 parts of tetrahydro methylpyrimidine carboxylic acid is high
0.45 part of active component of extraction of mountain plant, 2.5 parts of horse chestnut composite reactive ingredient, 0.2 part of essence.
The moisturizer is the mixing of glycerol, sorbierite, trehalose.The emulsifier is sucrose stearate/sucrose.
The pH adjusting agent is tromethamine.The preservative is parahydroxyacet-ophenone.The polyalcohol is propylene glycol, double
Third glycol.It is HERBA DENDROBII stem extraction, Angelica roots, Herba Verbenae, Radix Notoginseng that the high mountain, which plants extraction active component,
Root extract, tomonea extract, Chinese herbaceous peony root extract compound.
The De Minshu active constituent is answering for the effective components such as hydroxy phenylpropionyl amine benzoic acid, ascorbyl palmitate
Close object.
The horse chestnut composite reactive ingredient be panthenol, Ba 2672, glycerol, butcher's broom root extract, ammonium glycyrrhetate,
The compound of accumulated snow leaf extract, hydrolyzed yeast albumen and pot marigold flower extract.
The preparation method of the Red blood streak dispelling lotion, comprising the following steps:
1) component A is put into water phase pot, is heated with stirring to 85 DEG C, made it dissolve completely；
2) B component is put into oily phase pot, is heated with stirring to 85 DEG C, homogeneous makes it dissolve completely；
3) water phase material and oil phase material are sucked in succession in emulsifying kettle, keeps 85 DEG C of homogeneous 3min of temperature, keep the temperature 10 points
Cooling is stirred after clock；
4) when temperature drops to 60 DEG C, component C is added；
5) when temperature drops to 50 DEG C, the good D component of predissolve is added；
6) when temperature drops to 40 DEG C, stop agitation and filtration discharging.
Microorganism and service check are carried out to Red blood streak dispelling lotion made from above-described embodiment 1 to embodiment 3, it is specific to examine
As a result such as the following table 1, table 2.
The Micro biological Tests of 1 Red blood streak dispelling lotion of table
Analytical table 1 carries out Micro biological Tests it is found that examining according to the wholesomeness of " cosmetics health specification ", the present invention
Total plate count, mould and the yeast sum of Red blood streak dispelling lotion of the ingredient of composite reactive containing horse chestnut, fecal coliform class, golden yellow
The inspection of the projects such as color staphylococcus and pseudomonas aeruginosa meets the requirements, and illustrates that this clearly demarcated lotion is safe and reliable.
The detection performance of 2 Red blood streak dispelling lotion of table
Analytical table 2 is it is found that the pH value of Red blood streak dispelling lotion of the invention is 6.39-6.58 (standard 4.5-8.5), viscosity
Performance is 1700-3000 (standard 1000-6000cps), and relative density is 0.998-1.001 (standard 0.98-1.02), separately
Outside, appearance, odor type comply with standard, and cold-resistant, heat-resisting, centrifugation is tested without exception.
In addition, lotion produced by the present invention, has liquid crystal structure as shown in Figure 1.Due in liquid crystal structure, emulsifier
Molecule micella is intended to form multi-layer film structure.In such a configuration, the gel stratiform crystal phase of liquid crystal can be inserted into interface
In film, system is made to obtain enough hardness, reduce the fluctuation of interlayer substance, system is made to obtain sufficiently high stability.Stratiform knot
The water that can be accommodated among structure is very high.When being applied to skin surface, the structure of network shape will rupture, and moisture will be at once
It releases, generates good skin feel.
Water content may be up to 70% in liquid crystalline phase layer in lotion of the present invention: when cream is applied on skin, multilayer crystal phase
Rupture, alternate moisture can be distributed at once on skin and be absorbed by the skin, and have long-acting lasting moisture retention, while can repair
The cortex barrier of multiple skin.
Below for Red blood streak dispelling lotion of the invention, the situation after six weeks on probation is tested.
1, tested material: Red blood streak dispelling series, including Red blood streak dispelling facial cleaner, Red blood streak dispelling condensation, horse chestnut are releived maintenance
Essence, Red blood streak dispelling lotion, Red blood streak dispelling face cream；
2, the testing time: on January 20,9 days to 2018 December in 2017；
3, experimental method:
3.1 Subject characteristics: former trier totally 14 people, wherein male 3 people, 11 people of female (1 female because test is exited in adverse reaction, 2
Male exits test because of personal reason), real border totally 10 female, 1 male.
3.2 recipient sites: left and right face is smeared with Red blood streak dispelling series of products, left and right face can be used as two data.
3.3 products smear dosage: taking n grams of product to be uniformly applied to recipient site, two times a day, use sooner or later.
3.4 test indexs: keratoderma water content, fluid loss, black/haematochrome, VISA-CR image.
3.5 experimental procedures: test position is first cleaned before tester's test, after the 20min that sits quietly, is taken pictures and is observed with VISIA
The distribution of red capillary, the test indexs value such as (T0) water content, fluid loss, black/haematochrome before test recipient site sample is smeared, so
Tested material is smeared according to regulation dosage afterwards, and in smearing tested material 2 weeks (T1), 4 weeks (T2) and after 6 weeks (T3), tests tested portion
Position skin.During test, recipient site exposure places in test mode, keeps loosening.
3.6 analysis methods: by comparison face in the variation of each test index of each testing time point, then pass through image-
Pro plus and FRAMESCAN analysis software
4, experimental result:
The test result (table 3- table 8) of 4.1 each tested skins of subject
5, conclusion: the Red blood streak dispelling product can effectively reduce the amount of red capillary, and play the role of slight bright color.
Shadow data: 1 is dropped by the wayside the data of tester, and 1 temporary because using aloe makeup removing bubble to cause allergy
Postpone tester's data of test.For invalid data.
Concrete outcome is as shown in following table 3-8 and Fig. 2-7.
The variation of 3 tester's water content of stratum corneum of table
By table 3 and Fig. 2 it is found that the moisture content of each subject's left and right face is all increasing, and increase in the 6th week moisture content
Amount is most.Illustrate that the Red blood streak dispelling product has the function of increasing cuticula moisture content.
The variation of 4 tester's fluid loss of table
By table 4 and Fig. 3 it is found that the fluid loss of left and right face is reducing, and the reduction amount of T1, T2, T3 are in incremental trend.It says
The bright Red blood streak dispelling product can effectively reduce scattering and disappearing for moisture.
Each tester's content of hemachrome of table 5
By table 5 and Fig. 4 it is found that the ferroheme amount of left and right face is reduced, and reduction amount is most at the 6th week.Illustrate the product energy
Effectively reduce red capillary.
In addition, L*A*B:L* value is provided in relation to black-white-axis information, brightness.L* is higher, and pigment is fewer.A*- value
It is color space coordinate, A*- value changes erythema value on red-green-axis.A*- value is directly proportional to red (erythema/microcirculation).ITA
Value signifies the transparency of skin color, and ITA value is higher, and skin is brighter.
Each tester L value of table 6
It can be seen from table 6 and Fig. 5 when T1, T2, T3, it need to be analyzed in conjunction with ITA value, the L value in the LAB value of left and right face is all
It is increasing.
Each tester A value of table 7
The A value of left and right face all reduces it can be seen from table 7 and Fig. 6.Illustrate skin from red to green offset, heat flush subtracts
It is few.
Each tester ITA value of table 8
With the increase for using the time it can be seen from table 8 and Fig. 7, the ITA value of left and right face increases.Skin overall brightness
Increase.In conjunction with L value, it is known that the product plays the role of bright color.
In conjunction with the above content it is found that Red blood streak dispelling product of the present invention can effectively reduce red capillary, heat flush is reduced, effectively
Scattering and disappearing for moisture is reduced, plays the role of increasing cuticula moisture content, moreover it is possible to highlight the colour of skin of skin to a certain degree.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modification, equivalent replacement or improvement etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of Red blood streak dispelling lotion of the ingredient of composite reactive containing horse chestnut, which is characterized in that by weight, including with the following group
Point:
Component A: 0.01-0.5 parts of carbomer, 0.05-0.5 parts of xanthan gum, -6/ tert-butyl alcohol of polyacrylate cross-linked polymer
0.01-0.2 parts, 3-10 parts of moisturizer, 0.01-0.2 parts of Sodium Hyaluronate, 0.5-3 parts of polyethylene glycol-8, deionized water adds to
100 parts；
B component: 1.5-5 parts of emulsifier, 0.1-2 parts of dimethyl silicone polymer, 1-5 parts of caprylic/capric triglyceride, pentaerythrite
1-3 parts of pentaerythritol tetraisostearate, lauric alcohol-caprylate/0.5-2 parts of decylate, 0.5-3 parts of cetostearyl alcohol, phytosterol is different hard
0.2-1 parts of resin acid ester；
Component C: 0.01-0.3 parts of pH adjusting agent；
D component: 0.2-1.5 parts of preservative, 0.5-3 parts of polyalcohol；
Component E: 0.5-3 parts of panthenol, 0.01-0.5 parts of heparin sodium, 0.1-3 parts of De Minshu active constituent, tetrahydro methylpyrimidine carboxylic acid
0.5-2 parts, active component 0.1-0.5 parts of extraction of high mountain plant, 0.1-3 parts of horse chestnut composite reactive ingredient, 0.01-0.2 parts of essence.
2. a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut according to claim 1, which is characterized in that institute
The moisturizer stated is one of glycerol, 1,3 butylene glycol, dipropylene glycol, sorbierite, trehalose or a variety of mixing.
3. a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut according to claim 1, which is characterized in that institute
State emulsifier be stearine SE, polysorbate -20, sucrose stearate/sucrose, stearoyl-glutamic acid sodium one kind or
A variety of mixing.
4. a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut according to claim 1, which is characterized in that institute
Stating pH adjusting agent is one of triethanolamine, arginine, tromethamine or a variety of mixing.
5. a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut according to claim 1, which is characterized in that institute
Stating preservative is in 1,2- pentanediol, parahydroxyacet-ophenone, Phenoxyethanol, 1,2- hexylene glycol, methyl hydroxybenzoate or Nipasol
One or more mixing.
6. a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut according to claim 1, which is characterized in that institute
Stating polyalcohol is glycerol, dipropylene glycol, butanediol, propylene glycol, the one or more mixing of 1,2- pentanediol, diglycerol.
7. a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut according to claim 1, which is characterized in that institute
State high mountain plant extraction active component be HERBA DENDROBII stem extraction, Angelica roots, Herba Verbenae, Radix Notoginseng root extract,
Tomonea extract, Chinese herbaceous peony root extract compound.
8. a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut according to claim 1, which is characterized in that institute
Stating De Minshu active constituent includes hydroxy phenylpropionyl amine benzoic acid, ascorbyl palmitate.
9. a kind of Red blood streak dispelling lotion of ingredient of composite reactive containing horse chestnut according to claim 1, which is characterized in that institute
Horse chestnut composite reactive ingredient is stated to mention for panthenol, Ba 2672, glycerol, butcher's broom root extract, ammonium glycyrrhetate, accumulated snow blade of grass
Take the compound of object, hydrolyzed yeast albumen and pot marigold flower extract.
10. a kind of preparation method of any one of claim 1-9 Red blood streak dispelling lotion, which is characterized in that including following step
It is rapid:
1) component A is put into water phase pot, is heated with stirring to 80-85 DEG C, made it dissolve completely；
2) B component is put into oily phase pot, is heated with stirring to 80-85 DEG C, homogeneous makes it dissolve completely；
3) water phase material and oil phase material are sucked in succession in emulsifying kettle, keeps 80-85 DEG C of homogeneous 1-3min of temperature, keep the temperature 10 points
Cooling is stirred after clock；
4) when temperature drops to 60 DEG C, component C is added；
5) when temperature drops to 50 DEG C, the good D component of predissolve is added；
6) when temperature drops to 40 DEG C, stop agitation and filtration discharging.
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613678A (en) * | 2019-10-30 | 2019-12-27 | 广州留今科学研究有限公司 | Skin conditioner and essence for removing red blood streak and preparation method |
| CN111617023A (en) * | 2020-07-14 | 2020-09-04 | 北昊干细胞与再生医学研究院有限公司 | Eye composition and preparation method thereof |
| CN111700833A (en) * | 2020-07-13 | 2020-09-25 | 黄伟 | Facial cream for repairing plateau red skin and preparation method and application thereof |
| CN112353728A (en) * | 2020-11-25 | 2021-02-12 | 广州睿森生物科技有限公司 | Repairing composition and application thereof, cosmetics, essence and preparation method thereof |
| CN112656702A (en) * | 2021-01-11 | 2021-04-16 | 上海菩兰实业有限公司 | Application of aescin in eye cream |
| CN113244154A (en) * | 2021-05-11 | 2021-08-13 | 上海金皮宝制药有限公司 | Composition with effect of repairing sensitive red blood streak, essence preparation and preparation method of essence preparation |
| CN114099409A (en) * | 2021-11-09 | 2022-03-01 | 优颜皮肤科学研究(广州)有限公司 | Soothing and repairing composition and application thereof |
| CN115025009A (en) * | 2022-06-15 | 2022-09-09 | 羽楠(广州)化妆品有限公司 | Multifunctional Mannich root ice river mud space sand-shaped clean mud film and preparation method thereof |
| CN115300402A (en) * | 2022-08-22 | 2022-11-08 | 广州药妆日用化工有限公司 | Anti-allergy relieving repair emulsion and preparation method thereof |
| CN115887336A (en) * | 2022-11-22 | 2023-04-04 | 上海臻臣化妆品有限公司 | Skin-care composition and cosmetic |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102379838A (en) * | 2011-11-02 | 2012-03-21 | 广州舒泰生物技术有限公司 | Method for preparing relaxing and face-cleansing cosmetics and application |
| CN106551892A (en) * | 2015-09-20 | 2017-04-05 | 沈阳市坤美惜美容用品有限公司 | A kind of Red blood streak dispelling cosmetics and preparation method thereof |
| CN106619237A (en) * | 2016-12-16 | 2017-05-10 | 广东芭薇生物科技股份有限公司 | Plant compound extract-containing skin care composition |
| CN108158931A (en) * | 2018-03-26 | 2018-06-15 | 广东盛美化妆品有限公司 | A kind of moisturizing whitening cream of the extract containing Flos micheliae Albae and preparation method thereof |
| CN109172390A (en) * | 2018-09-26 | 2019-01-11 | 广东盛美化妆品有限公司 | A kind of multiple-effect of the extract containing Ganoderma Sinense is preserved youthful looks lotion and preparation method thereof |
| CN109745269A (en) * | 2017-11-07 | 2019-05-14 | 陕西博鸿生物科技集团有限公司 | A kind of red capillary maintenance essence and preparation method thereof |
-
2019
- 2019-05-31 CN CN201910471946.9A patent/CN110151650A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102379838A (en) * | 2011-11-02 | 2012-03-21 | 广州舒泰生物技术有限公司 | Method for preparing relaxing and face-cleansing cosmetics and application |
| CN106551892A (en) * | 2015-09-20 | 2017-04-05 | 沈阳市坤美惜美容用品有限公司 | A kind of Red blood streak dispelling cosmetics and preparation method thereof |
| CN106619237A (en) * | 2016-12-16 | 2017-05-10 | 广东芭薇生物科技股份有限公司 | Plant compound extract-containing skin care composition |
| CN109745269A (en) * | 2017-11-07 | 2019-05-14 | 陕西博鸿生物科技集团有限公司 | A kind of red capillary maintenance essence and preparation method thereof |
| CN108158931A (en) * | 2018-03-26 | 2018-06-15 | 广东盛美化妆品有限公司 | A kind of moisturizing whitening cream of the extract containing Flos micheliae Albae and preparation method thereof |
| CN109172390A (en) * | 2018-09-26 | 2019-01-11 | 广东盛美化妆品有限公司 | A kind of multiple-effect of the extract containing Ganoderma Sinense is preserved youthful looks lotion and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 广州水之语化妆品有限公司: "瑞雨丽洋甘菊即时修护原浆", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20180518155509XUNKU&NID=20180518155509XUNKU》 * |
| 水羊化妆品制造有限公司: "花瑶花金银花舒缓润妍乳液", 《HTTP://FTBA.NMPA.GOV.CN:8181/FTBAN/ITOWNET/HZP_BA/FW/PZ.JSP?PROCESSID=20170427115537EIXUB&NID=20170427115537EIXUB》 * |
| 石军等: "《肝脏微循环与慢性肝病》", 30 November 2010, 山东科技技术出版社 * |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110613678A (en) * | 2019-10-30 | 2019-12-27 | 广州留今科学研究有限公司 | Skin conditioner and essence for removing red blood streak and preparation method |
| CN110613678B (en) * | 2019-10-30 | 2022-05-17 | 广州留今科学研究有限公司 | Skin conditioner and essence for removing red blood streak and preparation method |
| CN111700833A (en) * | 2020-07-13 | 2020-09-25 | 黄伟 | Facial cream for repairing plateau red skin and preparation method and application thereof |
| CN111617023B (en) * | 2020-07-14 | 2022-07-01 | 北昊干细胞与再生医学研究院有限公司 | Eye composition and preparation method thereof |
| CN111617023A (en) * | 2020-07-14 | 2020-09-04 | 北昊干细胞与再生医学研究院有限公司 | Eye composition and preparation method thereof |
| CN112353728A (en) * | 2020-11-25 | 2021-02-12 | 广州睿森生物科技有限公司 | Repairing composition and application thereof, cosmetics, essence and preparation method thereof |
| CN112656702A (en) * | 2021-01-11 | 2021-04-16 | 上海菩兰实业有限公司 | Application of aescin in eye cream |
| CN113244154A (en) * | 2021-05-11 | 2021-08-13 | 上海金皮宝制药有限公司 | Composition with effect of repairing sensitive red blood streak, essence preparation and preparation method of essence preparation |
| CN114099409A (en) * | 2021-11-09 | 2022-03-01 | 优颜皮肤科学研究(广州)有限公司 | Soothing and repairing composition and application thereof |
| CN114099409B (en) * | 2021-11-09 | 2024-08-06 | 优颜皮肤科学研究(广州)有限公司 | Relief repair composition and application thereof |
| CN115025009A (en) * | 2022-06-15 | 2022-09-09 | 羽楠(广州)化妆品有限公司 | Multifunctional Mannich root ice river mud space sand-shaped clean mud film and preparation method thereof |
| CN115300402A (en) * | 2022-08-22 | 2022-11-08 | 广州药妆日用化工有限公司 | Anti-allergy relieving repair emulsion and preparation method thereof |
| CN115887336A (en) * | 2022-11-22 | 2023-04-04 | 上海臻臣化妆品有限公司 | Skin-care composition and cosmetic |
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Application publication date: 20190823 |